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Christopher W. Cowan, Ph.D. - Publications

Affiliations: 
McLean Hospital Harvard Medical School, Boston, MA, United States 
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Hughes BW, Siemsen BM, Tsvetkov E, Berto S, Kumar J, Cornbrooks RG, Akiki RM, Cho JY, Carter JS, Snyder KK, Assali A, Scofield MD, Cowan CW, Taniguchi M. NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses. Elife. 12. PMID 36780219 DOI: 10.7554/eLife.75631  0.681
2023 Anderson EM, Tsvetkov E, Galante A, DeVries D, McCue LM, Wood D, Barry S, Berto S, Lavin A, Taniguchi M, Cowan CW. Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 120: e2210953120. PMID 36745812 DOI: 10.1073/pnas.2210953120  0.737
2021 Anderson EM, Lopez MF, Kastner A, Mulholland PJ, Becker HC, Cowan CW. The histone methyltransferase G9a mediates stress-regulated alcohol drinking. Addiction Biology. e13060. PMID 34013595 DOI: 10.1111/adb.13060  0.4
2021 Assali A, Cho JY, Tsvetkov E, Gupta AR, Cowan CW. Sex-dependent role for EPHB2 in brain development and autism-associated behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33649502 DOI: 10.1038/s41386-021-00986-8  0.751
2020 Garcia-Keller C, Scofield MD, Neuhofer D, Varanasi S, Reeves MT, Hughes B, Anderson E, Richie CT, Mejias-Aponte C, Pickel J, Hope BT, Harvey BK, Cowan CW, Kalivas PW. Relapse-associated Transient Synaptic Potentiation Requires Integrin-mediated Activation of Focal Adhesion Kinase and Cofilin in D1-expressing Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33051346 DOI: 10.1523/JNEUROSCI.2666-19.2020  0.801
2020 Harrington AJ, Bridges CM, Berto S, Blankenship K, Cho JY, Assali A, Siemsen BM, Moore HW, Tsvetkov E, Thielking A, Konopka G, Everman DB, Scofield MD, Skinner SA, Cowan CW. MEF2C Hypofunction in Neuronal and Neuroimmune Populations Produces MEF2C Haploinsufficiency Syndrome-like Behaviors in Mice. Biological Psychiatry. PMID 32418612 DOI: 10.1016/J.Biopsych.2020.03.011  0.724
2019 Penrod RD, Thomsen M, Taniguchi M, Guo Y, Cowan CW, Smith LN. The activity-regulated cytoskeleton-associated protein, Arc/Arg3.1, influences mouse cocaine self-administration. Pharmacology, Biochemistry, and Behavior. 172818. PMID 31682894 DOI: 10.1016/J.Pbb.2019.172818  0.795
2019 Penrod RD, Kumar J, Smith LN, McCalley D, Nentwig T, Hughes B, Barry G, Glover K, Taniguchi M, Cowan CW. Activity-regulated cytoskeleton-associated protein (Arc/Arg3.1) regulates anxiety- and novelty-related behaviors. Genes, Brain, and Behavior. e12561. PMID 30761730 DOI: 10.1111/Gbb.12561  0.794
2018 Anderson EM, Sun H, Guzman D, Taniguchi M, Cowan CW, Maze I, Nestler EJ, Self DW. Knockdown of the histone di-methyltransferase G9a in nucleus accumbens shell decreases cocaine self-administration, stress-induced reinstatement, and anxiety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30587852 DOI: 10.1038/S41386-018-0305-4  0.792
2018 Anderson EM, Penrod RD, Barry SM, Hughes BW, Taniguchi M, Cowan CW. It's a complex issue: Emerging connections between epigenetic regulators in drug addiction. The European Journal of Neuroscience. PMID 30251397 DOI: 10.1111/Ejn.14170  0.773
2018 Penrod RD, Anderson EM, Cowan CW. Any Way You Splice It: New Molecular Mechanisms of Cocaine-Induced Alternative Gene Expression. Biological Psychiatry. PMID 29941147 DOI: 10.1016/j.biopsych.2018.06.004  0.446
2017 Li X, Carreria MB, Witonsky KR, Zeric T, Lofaro OM, Bossert JM, Zhang J, Surjono F, Richie CT, Harvey BK, Son H, Cowan CW, Nestler EJ, Shaham Y. Role of Dorsal Striatum Histone Deacetylase 5 in Incubation of Methamphetamine Craving. Biological Psychiatry. PMID 29397902 DOI: 10.1016/J.Biopsych.2017.12.008  0.398
2017 Guzman D, Carreira MB, Friedman AK, Adachi M, Neve RL, Monteggia LM, Han MH, Cowan CW, Self DW. Inactivation of NMDA Receptors in the Ventral Tegmental Area During Cocaine Self-Administration Prevents GluA1 Up-Regulation but with Paradoxical Increases in Cocaine-Seeking Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29196318 DOI: 10.1523/Jneurosci.2828-16.2017  0.648
2017 Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, ... ... Cowan CW, et al. HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors. Neuron. 96: 130-144.e6. PMID 28957664 DOI: 10.1016/J.Neuron.2017.09.015  0.771
2017 Anderson EM, Wissman AM, Chemplanikal J, Buzin N, Guzman D, Larson EB, Neve RL, Nestler EJ, Cowan CW, Self DW. BDNF-TrkB controls cocaine-induced dendritic spines in rodent nucleus accumbens dissociated from increases in addictive behaviors. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808012 DOI: 10.1073/Pnas.1702441114  0.741
2017 Penrod RD, Carreira MB, Taniguchi M, Kumar J, Maddox SA, Cowan CW. Novel role and regulation of HDAC4 in cocaine-related behaviors. Addiction Biology. PMID 28635037 DOI: 10.1111/Adb.12522  0.703
2016 Harrington AJ, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, Raduazzo J, Guo Y, Loerwald K, Konopka G, Huber KM, Cowan CW. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife. 5. PMID 27779093 DOI: 10.7554/Elife.20059  0.809
2016 Smith LN, Penrod RD, Taniguchi M, Cowan CW. Assessment of Cocaine-induced Behavioral Sensitization and Conditioned Place Preference in Mice. Journal of Visualized Experiments : Jove. PMID 26967472 DOI: 10.3791/53107  0.693
2016 Harrington AJ, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, Raduazzo J, Guo Y, Loerwald K, Konopka G, Huber KM, Cowan CW. Author response: MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders Elife. DOI: 10.7554/Elife.20059.023  0.79
2015 Robichaux MA, Chenaux G, Ho HH, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure. Developmental Neurobiology. PMID 26148571 DOI: 10.1002/Dneu.22323  0.776
2015 Robichaux MA, Chenaux G, Ho HYH, Soskis MJ, Greenberg ME, Henkemeyer M, Cowan CW. EphB1 and EphB2 intracellular domains regulate the formation of the corpus callosum and anterior commissure Developmental Neurobiology. DOI: 10.1002/dneu.22323  0.757
2014 Smith LN, Jedynak JP, Fontenot MR, Hale CF, Dietz KC, Taniguchi M, Thomas FS, Zirlin BC, Birnbaum SG, Huber KM, Thomas MJ, Cowan CW. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron. 82: 645-58. PMID 24811383 DOI: 10.1016/J.Neuron.2014.03.028  0.753
2014 Robichaux MA, Chenaux G, Ho HY, Soskis MJ, Dravis C, Kwan KY, Šestan N, Greenberg ME, Henkemeyer M, Cowan CW. EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding. Proceedings of the National Academy of Sciences of the United States of America. 111: 2188-93. PMID 24453220 DOI: 10.1073/Pnas.1324215111  0.765
2014 Robichaux MA, Cowan CW. Signaling mechanisms of axon guidance and early synaptogenesis. Current Topics in Behavioral Neurosciences. 16: 19-48. PMID 24318963 DOI: 10.1007/7854_2013_255  0.777
2013 Zang T, Maksimova MA, Cowan CW, Bassel-Duby R, Olson EN, Huber KM. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Molecular and Cellular Neurosciences. 56: 39-49. PMID 23511190 DOI: 10.1016/J.Mcn.2013.03.002  0.404
2013 Rothenfluh A, Cowan CW. Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'? Current Opinion in Neurobiology. 23: 507-12. PMID 23428655 DOI: 10.1016/J.Conb.2013.01.027  0.312
2013 Srivastava N, Robichaux MA, Chenaux G, Henkemeyer M, Cowan CW. EphB2 receptor forward signaling controls cortical growth cone collapse via Nck and Pak. Molecular and Cellular Neurosciences. 52: 106-16. PMID 23147113 DOI: 10.1016/J.Mcn.2012.11.003  0.774
2012 Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 151: 1581-94. PMID 23260144 DOI: 10.1016/J.Cell.2012.11.040  0.41
2012 Soskis MJ, Ho HY, Bloodgood BL, Robichaux MA, Malik AN, Ataman B, Rubin AA, Zieg J, Zhang C, Shokat KM, Sharma N, Cowan CW, Greenberg ME. A chemical genetic approach reveals distinct EphB signaling mechanisms during brain development. Nature Neuroscience. 15: 1645-54. PMID 23143520 DOI: 10.1038/Nn.3249  0.761
2012 Wang Y, He H, Srivastava N, Vikarunnessa S, Chen YB, Jiang J, Cowan CW, Zhang X. Plexins are GTPase-activating proteins for Rap and are activated by induced dimerization. Science Signaling. 5: ra6. PMID 22253263 DOI: 10.1126/Scisignal.2002636  0.336
2012 Taniguchi M, Carreira MB, Smith LN, Zirlin BC, Neve RL, Cowan CW. Histone deacetylase 5 limits cocaine reward through cAMP-induced nuclear import. Neuron. 73: 108-20. PMID 22243750 DOI: 10.1016/J.Neuron.2011.10.032  0.707
2011 Hale CF, Dietz KC, Varela JA, Wood CB, Zirlin BC, Leverich LS, Greene RW, Cowan CW. Essential role for vav Guanine nucleotide exchange factors in brain-derived neurotrophic factor-induced dendritic spine growth and synapse plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12426-36. PMID 21880903 DOI: 10.1523/Jneurosci.0685-11.2011  0.401
2010 Shen K, Cowan CW. Guidance molecules in synapse formation and plasticity. Cold Spring Harbor Perspectives in Biology. 2: a001842. PMID 20452946 DOI: 10.1101/Cshperspect.A001842  0.379
2010 Pfeiffer BE, Zang T, Wilkerson JR, Taniguchi M, Maksimova MA, Smith LN, Cowan CW, Huber KM. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 66: 191-7. PMID 20434996 DOI: 10.1016/J.Neuron.2010.03.017  0.704
2008 Meyer DA, Richer E, Benkovic SA, Hayashi K, Kansy JW, Hale CF, Moy LY, Kim Y, O'Callaghan JP, Tsai LH, Greengard P, Nairn AC, Cowan CW, Miller DB, Antich P, et al. Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology. Proceedings of the National Academy of Sciences of the United States of America. 105: 18561-6. PMID 19017804 DOI: 10.1073/Pnas.0806078105  0.388
2008 Cowan CW, Taniguchi M, Hale CF. Regulation of synaptic connectivity with chronic cocaine. The American Journal of Psychiatry. 165: 1393. PMID 18981071 DOI: 10.1176/Appi.Ajp.2008.08101465  0.738
2008 Pulipparacharuvil S, Renthal W, Hale CF, Taniguchi M, Xiao G, Kumar A, Russo SJ, Sikder D, Dewey CM, Davis MM, Greengard P, Nairn AC, Nestler EJ, Cowan CW. Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron. 59: 621-33. PMID 18760698 DOI: 10.1016/J.Neuron.2008.06.020  0.801
2006 Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Molecular and Cellular Biology. 26: 4830-42. PMID 16782872 DOI: 10.1128/Mcb.02215-05  0.339
2006 Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME. Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science (New York, N.Y.). 311: 1008-12. PMID 16484497 DOI: 10.1126/Science.1122511  0.778
2005 Sturla LM, Cowan CW, Guenther L, Castellino RC, Kim JY, Pomeroy SL. A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death. Cancer Research. 65: 5683-9. PMID 15994942 DOI: 10.1158/0008-5472.Can-04-2283  0.33
2005 Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 46: 205-17. PMID 15848800 DOI: 10.1016/J.Neuron.2005.03.019  0.783
2005 Sahin M, Greer PL, Lin MZ, Poucher H, Eberhart J, Schmidt S, Wright TM, Shamah SM, O'connell S, Cowan CW, Hu L, Goldberg JL, Debant A, Corfas G, Krull CE, et al. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron. 46: 191-204. PMID 15848799 DOI: 10.1016/J.Neuron.2005.01.030  0.798
2002 Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Developmental Cell. 3: 631-43. PMID 12431371 DOI: 10.1016/S1534-5807(02)00326-X  0.756
2002 Kornhauser JM, Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME. CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Neuron. 34: 221-33. PMID 11970864 DOI: 10.1016/S0896-6273(02)00655-4  0.787
2001 He W, Melia TJ, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. The Journal of Biological Chemistry. 276: 48961-6. PMID 11677233 DOI: 10.1074/Jbc.M107428200  0.708
2001 Griffith EC, Cowan CW, Greenberg ME. REST acts through multiple deacetylase complexes. Neuron. 31: 339-40. PMID 11516389 DOI: 10.1016/S0896-6273(01)00386-5  0.5
2001 Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. The Journal of Biological Chemistry. 276: 22287-95. PMID 11292825 DOI: 10.1074/Jbc.M011539200  0.665
2001 Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 409: 1071-7. PMID 11234020 DOI: 10.1038/35059138  0.56
2001 Cowan CW, He W, Wensel TG. RGS proteins: lessons from the RGS9 subfamily. Progress in Nucleic Acid Research and Molecular Biology. 65: 341-59. PMID 11008492 DOI: 10.1016/S0079-6603(00)65009-2  0.56
2000 He F, Seryshev AB, Cowan CW, Wensel TG. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. The Journal of Biological Chemistry. 275: 20572-7. PMID 10787404 DOI: 10.1074/Jbc.M000440200  0.531
2000 Cowan CW, Wensel TG, Arshavsky VY. Enzymology of GTPase acceleration in phototransduction. Methods in Enzymology. 315: 524-38. PMID 10736724 DOI: 10.1016/S0076-6879(00)15865-3  0.516
1999 Rahman Z, Gold SJ, Potenza MN, Cowan CW, Ni YG, He W, Wensel TG, Nestler EJ. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2016-26. PMID 10066255 DOI: 10.1523/Jneurosci.19-06-02016.1999  0.647
1998 Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proceedings of the National Academy of Sciences of the United States of America. 95: 5351-6. PMID 9560279 DOI: 10.1073/Pnas.95.9.5351  0.555
1998 He W, Cowan CW, Wensel TG. RGS9, a GTPase accelerator for phototransduction. Neuron. 20: 95-102. PMID 9459445 DOI: 10.1016/S0896-6273(00)80437-7  0.537
1997 Melia TJ, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophysical Journal. 73: 3182-91. PMID 9414230 DOI: 10.1016/S0006-3495(97)78344-9  0.763
1996 Cowan CW, Angleson JK, Wensel TG. Solubilization and partial purification of Gtα-GAP from rod outer segment membranes Investigative Ophthalmology and Visual Science. 37: S809.  0.71
1996 Wensel TG, Seryshev A, Cowan CW. Zinc and retinal cGMP phosphodiesterase Investigative Ophthalmology and Visual Science. 37: S239.  0.449
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