Mike Lumb - Publications

Affiliations: 
NPP University College London, London, United Kingdom 

75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Terunuma M, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 804-16. PMID 24431439 DOI: 10.1523/JNEUROSCI.3320-13.2013  1
2012 Gielen MC, Lumb MJ, Smart TG. Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5707-15. PMID 22539833 DOI: 10.1523/JNEUROSCI.5663-11.2012  1
2010 Smith KR, Oliver PL, Lumb MJ, Arancibia-Carcamo IL, Revilla-Sanchez R, Brandon NJ, Moss SJ, Kittler JT. Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons. Molecular and Cellular Neurosciences. 44: 330-41. PMID 20417281 DOI: 10.1016/j.mcn.2010.04.004  1
2010 Twelvetrees AE, Yuen EY, Arancibia-Carcamo IL, MacAskill AF, Rostaing P, Lumb MJ, Humbert S, Triller A, Saudou F, Yan Z, Kittler JT. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Neuron. 65: 53-65. PMID 20152113 DOI: 10.1016/j.neuron.2009.12.007  1
2009 Arancibia-Cárcamo IL, Yuen EY, Muir J, Lumb MJ, Michels G, Saliba RS, Smart TG, Yan Z, Kittler JT, Moss SJ. Ubiquitin-dependent lysosomal targeting of GABA(A) receptors regulates neuronal inhibition. Proceedings of the National Academy of Sciences of the United States of America. 106: 17552-7. PMID 19815531 DOI: 10.1073/pnas.0905502106  1
2005 Huber PA, Birdsey GM, Lumb MJ, Prowse DT, Perkins TJ, Knight DR, Danpure CJ. Peroxisomal import of human alanine:glyoxylate aminotransferase requires ancillary targeting information remote from its C terminus. The Journal of Biological Chemistry. 280: 27111-20. PMID 15911627 DOI: 10.1074/jbc.M502719200  1
2005 Cheng L, Lumb M, Polgár L, Mudge AW. How can the mood stabilizer VPA limit both mania and depression? Molecular and Cellular Neurosciences. 29: 155-61. PMID 15911340 DOI: 10.1016/j.mcn.2004.12.003  1
2003 Lumb MJ, Birdsey GM, Danpure CJ. Correction of an enzyme trafficking defect in hereditary kidney stone disease in vitro. The Biochemical Journal. 374: 79-87. PMID 12737622 DOI: 10.1042/BJ20030371  1
2003 Danpure CJ, Lumb MJ, Birdsey GM, Zhang X. Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease. Biochimica Et Biophysica Acta. 1647: 70-5. PMID 12686111 DOI: 10.1016/S1570-9639(03)00055-4  1
2000 Lumb MJ, Danpure CJ. Functional synergism between the most common polymorphism in human alanine:glyoxylate aminotransferase and four of the most common disease-causing mutations. The Journal of Biological Chemistry. 275: 36415-22. PMID 10960483 DOI: 10.1074/jbc.M006693200  1
1999 Lumb MJ, Drake AF, Danpure CJ. Effect of N-terminal alpha-helix formation on the dimerization and intracellular targeting of alanine:glyoxylate aminotransferase. The Journal of Biological Chemistry. 274: 20587-96. PMID 10400689 DOI: 10.1074/jbc.274.29.20587  1
1997 Workman BJ, Lumb BM. Inhibitory effects evoked from the anterior hypothalamus are selective for the nociceptive responses of dorsal horn neurons with high- and low-threshold inputs. Journal of Neurophysiology. 77: 2831-5. PMID 9163397  1
1996 Oatey PB, Lumb MJ, Jennings PR, Danpure CJ. Context dependency of the PTS1 motif in human alanine: glyoxylate aminotransferase 1. Annals of the New York Academy of Sciences. 804: 652-3. PMID 8993581 DOI: 10.1111/j.1749-6632.1996.tb18653.x  1
1996 Danpure CJ, Jennings PR, Leiper JM, Lumb MJ, Oatey PB. Targeting of alanine: glyoxylate aminotransferase in normal individuals and its mistargeting in patients with primary hyperoxaluria type 1. Annals of the New York Academy of Sciences. 804: 477-90. PMID 8993566 DOI: 10.1111/j.1749-6632.1996.tb18638.x  1
1996 Oatey PB, Lumb MJ, Danpure CJ. Molecular basis of the variable mitochondrial and peroxisomal localisation of alanine-glyoxylate aminotransferase. European Journal of Biochemistry / Febs. 241: 374-85. PMID 8917433 DOI: 10.1111/j.1432-1033.1996.00374.x  1
1995 Motley A, Lumb MJ, Oatey PB, Jennings PR, De Zoysa PA, Wanders RJ, Tabak HF, Danpure CJ. Mammalian alanine/glyoxylate aminotransferase 1 is imported into peroxisomes via the PTS1 translocation pathway. Increased degeneracy and context specificity of the mammalian PTS1 motif and implications for the peroxisome-to-mitochondrion mistargeting of AGT in primary hyperoxaluria type 1. The Journal of Cell Biology. 131: 95-109. PMID 7559790  1
1994 Lumb MJ, Purdue PE, Danpure CJ. Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the feline gene. European Journal of Biochemistry / Febs. 221: 53-62. PMID 8168541  1
1994 Danpure CJ, Birdsey GM, Rumsby G, Lumb MJ, Purdue PE, Allsop J. Molecular characterization and clinical use of a polymorphic tandem repeat in an intron of the human alanine:glyoxylate aminotransferase gene. Human Genetics. 94: 55-64. PMID 8034295 DOI: 10.1007/BF02272842  1
1993 Danpure CJ, Purdue PE, Fryer P, Griffiths S, Allsop J, Lumb MJ, Guttridge KM, Jennings PR, Scheinman JI, Mauer SM. Enzymological and mutational analysis of a complex primary hyperoxaluria type 1 phenotype involving alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting and intraperoxisomal aggregation. American Journal of Human Genetics. 53: 417-32. PMID 8101040  1
1992 Chanarin I, Deacon R, Lumb M, Perry J. Cobalamin and folate: recent developments. Journal of Clinical Pathology. 45: 277-83. PMID 1577963  1
1992 Purdue PE, Lumb MJ, Allsop J, Minatogawa Y, Danpure CJ. A glycine-to-glutamate substitution abolishes alanine:glyoxylate aminotransferase catalytic activity in a subset of patients with primary hyperoxaluria type 1. Genomics. 13: 215-8. PMID 1349575 DOI: 10.1016/0888-7543(92)90225-H  1
1992 Purdue PE, Lumb MJ, Danpure CJ. Molecular evolution of alanine/glyoxylate aminotransferase 1 intracellular targeting. Analysis of the marmoset and rabbit genes. European Journal of Biochemistry / Febs. 207: 757-66. PMID 1339350 DOI: 10.1111/j.1432-1033.1992.tb17106.x  1
1991 Purdue PE, Lumb MJ, Fox M, Griffo G, Hamon-Benais C, Povey S, Danpure CJ. Characterization and chromosomal mapping of a genomic clone encoding human alanine:glyoxylate aminotransferase. Genomics. 10: 34-42. PMID 2045108 DOI: 10.1016/0888-7543(91)90481-S  1
1991 Purdue PE, Lumb MJ, Allsop J, Danpure CJ. An intronic duplication in the alanine: glyoxylate aminotransferase gene facilitates identification of mutations in compound heterozygote patients with primary hyperoxaluria type 1. Human Genetics. 87: 394-6. PMID 1879825 DOI: 10.1007/BF00197154  1
1990 Deacon R, Perry J, Lumb M, Chanarin I. Cobalamin inactivation induces formyltetrahydrofolate synthetase. Febs Letters. 263: 303-4. PMID 2335231 DOI: 10.1016/0014-5793(90)81399-9  1
1990 Deacon R, Perry J, Lumb M, Chanarin I. Formate metabolism in the cobalamin-inactivated rat. British Journal of Haematology. 74: 354-9. PMID 2334642  1
1990 Deacon R, Bottiglieri T, Chanarin I, Lumb M, Perry J. Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells. Biochimica Et Biophysica Acta. 1034: 342-6. PMID 2114175 DOI: 10.1016/0304-4165(90)90062-2  1
1990 Perry J, Chanarin I, Deacon R, Lumb M. Methylation of DNA in megaloblastic anaemia. Journal of Clinical Pathology. 43: 211-2. PMID 1692039  1
1989 Lumb M, Deacon R, Perry J, Chanarin I. Oxidation of 5-methyltetrahydrofolate in cobalamin-inactivated rats. The Biochemical Journal. 258: 907-10. PMID 2730574  1
1989 Lumb M, Bottiglieri T, Deacon R, Perry J, Chanarin I. Regulation of 5-methyltetrahydrofolate synthesis. The Biochemical Journal. 258: 611-2. PMID 2706003  1
1989 Chanarin I, Deacon R, Lumb M, Perry J. Cobalamin-folate interrelations. Blood Reviews. 3: 211-5. PMID 2692743 DOI: 10.1016/0268-960X(89)90028-3  1
1988 Lumb M, Chanarin I, Deacon R, Perry J. In vivo oxidation of the methyl group of hepatic 5-methyltetrahydrofolate. Journal of Clinical Pathology. 41: 1158-62. PMID 3145288 DOI: 10.1136/jcp.41.11.1158  1
1987 Perry J, Deacon R, Lumb M, Chanarin I. Impaired formylation and uptake of tetrahydrofolate by rat small gut following cobalamin inactivation. Biochimica Et Biophysica Acta. 923: 286-90. PMID 3814618 DOI: 10.1016/0304-4165(87)90015-8  1
1986 Keeling PA, Rocke DA, Nunn JF, Monk SJ, Lumb MJ, Halsey MJ. Folinic acid protection against nitrous oxide teratogenicity in the rat. British Journal of Anaesthesia. 58: 528-34. PMID 3485983  1
1986 Deacon R, Purkiss P, Green R, Lumb M, Perry J, Chanarin I. Vitamin B12 neuropathy is not due to failure to methylate myelin basic protein. Journal of the Neurological Sciences. 72: 113-7. PMID 2419513 DOI: 10.1016/0022-510X(86)90040-7  1
1985 Deacon R, Chanarin I, Lumb M, Perry J. Role of folate dependent transformylases in synthesis of purine in bone marrow of man and in bone marrow and liver of rats. Journal of Clinical Pathology. 38: 1349-52. PMID 4078017 DOI: 10.1136/jcp.38.12.1349  1
1985 Lumb M, Chanarin I, Perry J, Deacon R. Turnover of the methyl moiety of 5-methyltetrahydropteroylglutamic acid in the cobalamin-inactivated rat. Blood. 66: 1171-5. PMID 4052631  1
1985 Perry J, Chanarin I, Deacon R, Lumb M. Folate polyglutamate synthetase activity in the cobalamin-inactivated rat. The Biochemical Journal. 227: 73-7. PMID 3994694  1
1985 Deacon R, Perry J, Lumb M, Chanarin I. Effect of cobalamin inactivation on folate-dependent transformylases involved in purine synthesis in rats. The Biochemical Journal. 227: 67-71. PMID 3994693  1
1985 Chanarin I, Deacon R, Lumb M, Muir M, Perry J. Cobalamin-folate interrelations: a critical review. Blood. 66: 479-89. PMID 2862932  1
1983 Perry J, Chanarin I, Deacon R, Lumb M. Chronic cobalamin inactivation impairs folate polyglutamate synthesis in the rat. The Journal of Clinical Investigation. 71: 1183-90. PMID 6853707  1
1983 Deacon R, Perry J, Lumb M, Chanarin I. Effect of nitrous oxide-induced inactivation of vitamin B12 on glycinamide ribonucleotide transformylase and 5-amino-4-imidazole carboxamide transformylase. Biochemical and Biophysical Research Communications. 112: 327-31. PMID 6838615 DOI: 10.1016/0006-291X(83)91834-X  1
1983 Lumb M, Sharer N, Deacon R, Jennings P, Purkiss P, Perry J, Chanarin I. Effects of nitrous oxide-induced inactivation of cobalamin on methionine and S-adenosylmethionine metabolism in the rat. Biochimica Et Biophysica Acta. 756: 354-9. PMID 6830860 DOI: 10.1016/0304-4165(83)90345-8  1
1983 Deacon R, Perry J, Lumb M, Chanarin I. Increased urinary excretion of formiminoglutamic acid in nitrous-oxide-treated rats and its reduction by methionine. European Journal of Biochemistry / Febs. 129: 627-8. PMID 6825678  1
1983 Skacel PO, Hewlett AM, Lewis JD, Lumb M, Nunn JF, Chanarin I. Studies on the haemopoietic toxicity of nitrous oxide in man. British Journal of Haematology. 53: 189-200. PMID 6821648  1
1983 Perry J, Deacon R, Lumb M, Chanarin I. Impairment of folate polyglutamate synthesis following B12 inactivation: Correction by methionine, s-adenosyl-methionine and 5' methylthioadenosine British Journal of Haematology. 53: 348-349.  1
1982 Lumb M, Perry J, Deacon R, Chanarin I. Urinary folate loss following inactivation of vitamin B12 by nitrous oxide in rats. British Journal of Haematology. 51: 235-42. PMID 7082582  1
1982 Deacon R, Chanarin I, Perry J, Lumb M. A comparison of tetrahydrofolate and 5-formyltetrahydrofolate in correcting the impairment of thymidine synthesis in pernicious anaemia. Scandinavian Journal of Haematology. 28: 289-92. PMID 6981199  1
1982 Deacon R, Lumb MJ, Perry J. Vitamin B12, folate and nitrous oxide. Medical Laboratory Sciences. 39: 171-8. PMID 6750303  1
1982 Chanarin I, Lumb M, Perry J, Deacon R. How folate deficiency develops following inactivation of cobalamin by nitrous oxide (N2O) British Journal of Haematology. 51: 328.  1
1981 Lumb M, Perry J, Deacon R, Chanarin I. Changes in plasma folate levels in rats inhaling nitrous oxide. Scandinavian Journal of Haematology. 26: 61-4. PMID 7466319  1
1981 Deacon R, Jennings P, Lumb M, Perry J, Purkiss P, Chanarin I. The effect of nitrous oxide-induced inactivation of cobalamin on plasma amino acid levels in the rat. Scandinavian Journal of Haematology. 27: 267-70. PMID 7346992  1
1981 Deacon R, Chanarin I, Perry J, Lumb M. The effect of folate analogues on the thymidine utilization by human and rat marrow cells and the effect on the deoxyuridine suppression test. Postgraduate Medical Journal. 57: 611-6. PMID 7335559 DOI: 10.1136/pgmj.57.672.611  1
1981 Deacon R, Perry J, Lumb M, Chanarin I. The effect of nitrous oxide-induced inactivation of vitamin B12 on thymidylate synthetase activity of rat bone marrow cells. Biochemical and Biophysical Research Communications. 102: 215-8. PMID 7306148 DOI: 10.1016/0006-291X(81)91509-6  1
1981 Lumb M, Perry J, Deacon R, Chanarin I. Recovery of tissue folates after inactivation of cobalamin by nitrous oxide. The significance of dietary folate. The American Journal of Clinical Nutrition. 34: 2418-22. PMID 7304483  1
1981 Lumb M, Perry J, Deacon R, Chanarin I. Changes in tissue folates accompanying nitrous oxide-induced inactivation of vitamin B12 in the rat. The American Journal of Clinical Nutrition. 34: 2412-7. PMID 7304482  1
1981 Chanarin I, Deacon R, Perry J, Lumb M. How vitamin B12 acts. British Journal of Haematology. 47: 487-91. PMID 7213572  1
1981 Swinson CM, Perry J, Lumb M, Levi AJ. Role of sulphasalazine in the aetiology of folate deficiency in ulcerative colitis. Gut. 22: 456-61. PMID 6114899  1
1981 Skacel P, Chanarin I, Lumb M. Serial studies on the effects of nitrous oxide (N2O) in man British Journal of Haematology. 49: 137.  1
1981 Deacon R, Perry J, Lumb M, Chanarin I. The effect of nitrous oxide-induced inactivation of vitamin B12 on folate-mediated single-carbon unit transfer British Journal of Haematology. 47: 628-629.  1
1980 Deacon R, Chanarin I, Perry J, Lumb M. Marrow cells from patients with untreated pernicious anaemia cannot use tetrahydrofolate normally. British Journal of Haematology. 46: 523-8. PMID 7437330  1
1980 Perry J, Lumb M, van der Westhuyzen J, Fernandes-Costa F, Metz J, Chanarin I. Utilization of [2-14C]tetrahydropteroylglutamic acid and 5-[G-3H]methyltetrahydropteroylglutamic acid as substrates for folate polyglutamate synthesis in fruit bats: effect of vitamin B-12-deficiency. Biochimica Et Biophysica Acta. 629: 566-76. PMID 7417512 DOI: 10.1016/0304-4165(80)90162-2  1
1980 Lumb M, Deacon R, Perry J, Chanarin I, Minty B, Halsey MJ, Nunn JF. The effect of nitrous oxide inactivation of vitamin B12 on rat hepatic folate. Implications for the methylfolate-trap hypothesis. The Biochemical Journal. 186: 933-6. PMID 7396845  1
1980 Deacon R, Chanarin I, Perry J, Lumb M. Impaired deoxyuridine utilization in the B12-inactivated rat and its correction by folate analogues. Biochemical and Biophysical Research Communications. 93: 516-20. PMID 7387656 DOI: 10.1016/0006-291X(80)91107-9  1
1980 Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey M, Nunn J. Inactivation of methionine synthase by nitrous oxide. European Journal of Biochemistry / Febs. 104: 419-23. PMID 7363899  1
1980 Deacon R, Perry J, Lumb M, Chanarin I. The effect of nitrous oxide-induced inactivation of vitamin B12 on serine transhydroxymethylase. Biochemical and Biophysical Research Communications. 97: 1324-8. PMID 7213359 DOI: 10.1016/S0006-291X(80)80011-8  1
1980 Perry J, Deacon R, Lumb M, Chanarin I. The effect of nitrous oxide-induced inactivation of vitamin B12 on the activity of formyl-methenyl-methylenetetrahydrofolate synthetase, methylene-tetrahydrofolate reductase and formiminotetrahydrofolate transferase. Biochemical and Biophysical Research Communications. 97: 1329-33. PMID 6971097 DOI: 10.1016/S0006-291X(80)80012-X  1
1980 Chanarin I, Deacon R, Lumb M, Perry J. Vitamin B12 regulates folate metabolism by the supply of formate. Lancet. 2: 505-7. PMID 6105561  1
1979 Perry J, Chanarin I, Deacon R, Lumb M. The substrate for folate polyglutamate biosynthesis in the vitamin B12-inactivated rat. Biochemical and Biophysical Research Communications. 91: 678-84. PMID 518661 DOI: 10.1016/0006-291X(79)91575-4  1
1979 Perry J, Lumb M, Van Der Westhuyzen J, Fernandes-Costa F, Metz J, Chanarin I. Characterization of endogenous folate and incorporation of labelled folates into the brain of the South African fruit bat. Biochimica Et Biophysica Acta. 586: 632-6. PMID 476159 DOI: 10.1016/0304-4165(79)90054-0  1
1979 Minty B, Deacon R, Lumb M. Effect of nitrous oxide on B12-requiring enzymes British Journal of Anaesthesia. 51: 65P-66P.  1
1978 Deacon R, Lumb M, Perry J, Chanarin I, Minty B, Halsey MJ, Nunn JF. Selective inactivation of vitamin B12 in rats by nitrous oxide. Lancet. 2: 1023-4. PMID 82036 DOI: 10.1016/S0140-6736(78)92341-3  1
1976 Perry J, Lumb M, Laundy M, Reynolds EH, Chanarin I. Role of vitamin B12 in folate coenzyme synthesis. British Journal of Haematology. 32: 243-8. PMID 1247496  1
1975 Perry J, Lumb M, Chanarin I. Red blood cell polyglutamyl folates in vitamin B12 deficiency British Journal of Haematology. 30: 123.  1
1974 Chanarin I, Perry J, Lumb M. The biochemical lesion in vitamin-B12 deficiency in man. Lancet. 1: 1251-2. PMID 4134140 DOI: 10.1016/S0140-6736(74)90005-1  1
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