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Kristoffer Sahlholm - Publications

Affiliations: 
Karolinska Institute, Stockholm, Sweden 
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56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Ågren R, Betari N, Saarinen M, Zeberg H, Svenningsson P, Sahlholm K. In Vitro Comparison of Ulotaront (SEP-363856) and Ralmitaront (RO6889450) - Two TAAR1 Agonist Candidate Antipsychotics. The International Journal of Neuropsychopharmacology. PMID 37549917 DOI: 10.1093/ijnp/pyad049  0.703
2023 Ågren R, Patil S, Zhou X, Sahlholm K, Pääbo S, Zeberg H. Major Genetic Risk Factors for Dupuytren's Disease Are Inherited From Neandertals. Molecular Biology and Evolution. 40. PMID 37315093 DOI: 10.1093/molbev/msad130  0.584
2023 Burström V, Ågren R, Betari N, Valle-León M, Garro-Martínez E, Ciruela F, Sahlholm K. Dopamine-induced arrestin recruitment and desensitization of the dopamine D4 receptor is regulated by G protein-coupled receptor kinase-2. Frontiers in Pharmacology. 14: 1087171. PMID 36778010 DOI: 10.3389/fphar.2023.1087171  0.838
2023 Valle-León M, Casajuana-Martin N, Del Torrent CL, Argerich J, Gómez-Acero L, Sahlholm K, Ferré S, Pardo L, Ciruela F. Unique effect of clozapine on adenosine A-dopamine D receptor heteromerization. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 160: 114327. PMID 36736280 DOI: 10.1016/j.biopha.2023.114327  0.817
2022 Saarinen M, Mantas I, Flais I, Ågren R, Sahlholm K, Millan MJ, Svenningsson P. Correction To: TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT receptor agonist SEP- 363856. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 36446929 DOI: 10.1038/s41386-022-01504-0  0.31
2022 Saarinen M, Mantas I, Flais I, Ågren R, Sahlholm K, Millan MJ, Svenningsson P. TAAR1 dependent and independent actions of the potential antipsychotic and dual TAAR1/5-HT receptor agonist SEP-383856. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 36100653 DOI: 10.1038/s41386-022-01421-2  0.435
2021 Ågren R, Sahlholm K. Evidence for Two Modes of Binding of the Negative Allosteric Modulator SB269,652 to the Dopamine D Receptor. Biomedicines. 10. PMID 35052702 DOI: 10.3390/biomedicines10010022  0.426
2021 Stepniewski TM, Mancini A, Ågren R, Torrens-Fontanals M, Semache M, Bouvier M, Sahlholm K, Breton B, Selent J. Mechanistic insights into dopaminergic and serotonergic neurotransmission - concerted interactions with helices 5 and 6 drive the functional outcome. Chemical Science. 12: 10990-11003. PMID 34522296 DOI: 10.1039/d1sc00749a  0.417
2021 López-Cano M, Font J, Aso E, Sahlholm K, Cabré G, Giraldo J, De Koninck Y, Hernando J, Llebaria A, Fernández-Dueñas V, Ciruela F. Remote local photoactivation of morphine produces analgesia without opioid-related adverse effects. British Journal of Pharmacology. PMID 34363210 DOI: 10.1111/bph.15645  0.742
2021 Ågren R, Stepniewski TM, Zeberg H, Selent J, Sahlholm K. Dopamine D Receptor Agonist Binding Kinetics-Role of a Conserved Serine Residue. International Journal of Molecular Sciences. 22. PMID 33920848 DOI: 10.3390/ijms22084078  0.697
2021 Hsieh CJ, Riad A, Lee JY, Sahlholm K, Xu K, Luedtke RR, Mach RH. Interaction of Ligands for PET with the Dopamine D3 Receptor: In Silico and In Vitro Methods. Biomolecules. 11. PMID 33918451 DOI: 10.3390/biom11040529  0.343
2021 Paucar M, Ågren R, Li T, Lissmats S, Bergendal Å, Weinberg J, Nilsson D, Savichetva I, Sahlholm K, Nilsson J, Svenningsson P. V374A KCND3 Pathogenic Variant Associated With Paroxysmal Ataxia Exacerbations. Neurology. Genetics. 7: e546. PMID 33575485 DOI: 10.1212/NXG.0000000000000546  0.406
2020 Betari N, Sahlholm K, Morató X, Godoy-Marín H, Jáuregui O, Teigen K, Ciruela F, Haavik J. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- and Investigations. Frontiers in Pharmacology. 11: 593416. PMID 33324221 DOI: 10.3389/fphar.2020.593416  0.725
2020 Ågren R, Sahlholm K. Voltage-Dependent Dopamine Potency at D-Like Dopamine Receptors. Frontiers in Pharmacology. 11: 581151. PMID 33117177 DOI: 10.3389/fphar.2020.581151  0.472
2020 Valle-León M, Callado LF, Aso E, Cajiao-Manrique MM, Sahlholm K, López-Cano M, Soler C, Altafaj X, Watanabe M, Ferré S, Fernández-Dueñas V, Menchón JM, Ciruela F. Decreased striatal adenosine A-dopamine D receptor heteromerization in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 33010795 DOI: 10.1038/s41386-020-00872-9  0.779
2020 Ågren R, Zeberg H, Maciej Stępniewski T, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K. A ligand with two modes of interaction with the dopamine D2 receptor - An induced-fit mechanism of insurmountable antagonism. Acs Chemical Neuroscience. PMID 32865974 DOI: 10.1021/Acschemneuro.0C00477  0.818
2020 Zeberg H, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, Hevers W, Robinson HPC, Kelso J, Pääbo S. A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. Current Biology : Cb. PMID 32707058 DOI: 10.1016/J.Cub.2020.06.045  0.637
2020 Ågren R, Sahlholm K. Voltage-Dependent Dopamine Potency at D1-Like Dopamine Receptors Frontiers in Pharmacology. 11. DOI: 10.3389/fphar.2020.581151  0.439
2019 Reilly SW, Riad AA, Hsieh CJ, Sahlholm K, Jacome DA, Griffin S, Taylor M, Weng CC, Xu K, Kirschner N, Luedtke RR, Parry C, Malhotra S, Karanicolas J, Mach RH. Leveraging a Low Affinity Diazaspiro Orthosteric Fragment to Reduce Dopamine D3 Receptor (D3R) Ligand Promiscuity Across Highly Conserved Aminergic G-Protein-Coupled Receptors (GPCRs). Journal of Medicinal Chemistry. PMID 31021617 DOI: 10.1021/Acs.Jmedchem.9B00412  0.412
2018 Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F. Dopamine receptor heteromers: biasing antipsychotics. Future Medicinal Chemistry. PMID 30518245 DOI: 10.4155/Fmc-2018-0335  0.817
2018 Zeberg H, Sahlholm K. Antipsychotics with similar association kinetics at dopamine D receptors differ in extrapyramidal side-effects. Nature Communications. 9: 3577. PMID 30177830 DOI: 10.1038/S41467-018-04489-X  0.698
2018 Ågren R, Århem P, Nilsson J, Sahlholm K. The beta-arrestin-biased dopamine D2 receptor ligand, UNC9994, is a partial agonist at G-protein-mediated potassium channel activation. The International Journal of Neuropsychopharmacology. PMID 29986044 DOI: 10.1093/Ijnp/Pyy059  0.762
2018 Sahlholm K, Valle-Leon M, Taura J, Fernandez-Duenas V, Ciruela F. Effects of the Dopamine Stabilizer, Pridopidine, on Basal and Phencyclidine-Induced Locomotion: Role of Dopamine D2 and Sigma-1 Receptors. Cns & Neurological Disorders Drug Targets. PMID 29952269 DOI: 10.2174/1871527317666180627103337  0.803
2018 Sahlholm K, Valle-León M, Fernández-Dueñas V, Ciruela F. Pridopidine Reverses Phencyclidine-Induced Memory Impairment. Frontiers in Pharmacology. 9: 338. PMID 29692729 DOI: 10.3389/Fphar.2018.00338  0.78
2018 Ågren R, Sahlholm K, Nilsson J, Århem P. Point mutation of a conserved aspartate, D69, in the muscarinic M2 receptor does not modify voltage-sensitive agonist potency. Biochemical and Biophysical Research Communications. PMID 29305262 DOI: 10.1016/J.Bbrc.2018.01.005  0.709
2017 Reilly SW, Griffin S, Taylor M, Sahlholm K, Weng CC, Xu K, Jacome DA, Luedtke RR, Mach RH. Highly Selective Dopamine D3 Receptor Antagonists with Arylated Diazaspiro Alkane Cores. Journal of Medicinal Chemistry. PMID 29125762 DOI: 10.1021/Acs.Jmedchem.7B01248  0.354
2017 Taura J, Valle-León M, Sahlholm K, Watanabe M, Van Craenenbroeck K, Fernández-Dueñas V, Ferré S, Ciruela F. Behavioral control by striatal A2A -dopamine D2 receptor heteromers. Genes, Brain, and Behavior. PMID 29053217 DOI: 10.1111/Gbb.12432  0.596
2017 Sahlholm K, Gómez-Soler M, Valle-León M, López-Cano M, Taura JJ, Ciruela F, Fernández-Dueñas V. Antipsychotic-Like Efficacy of Dopamine D2 Receptor-Biased Ligands is Dependent on Adenosine A2A Receptor Expression. Molecular Neurobiology. PMID 28779351 DOI: 10.1007/S12035-017-0696-Y  0.738
2017 Sahlholm K, Ielacqua GD, Xu J, Jones LA, Schlegel F, Mach RH, Rudin M, Schroeter A. The role of beta-arrestin2 in shaping fMRI BOLD responses to dopaminergic stimulation. Psychopharmacology. PMID 28382543 DOI: 10.1007/S00213-017-4609-6  0.345
2016 Sahlholm K, Zeberg H, Nilsson J, Ögren SO, Fuxe K, Århem P. The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26811292 DOI: 10.1016/J.Euroneuro.2016.01.001  0.822
2015 Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Fariñas S, Martinez-Romero A, Fernandez Dueñas V, Sahlholm K, Knopfel T, Garcia-Valverde M, Rodilla AM, Jantus-Lewintre E, Farras R, Ciruela F, Perez-Tomas R, Quesada R. Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane that Triggers Differentiation and Cell Death in Cancer Stem Cells. Journal of the American Chemical Society. PMID 26632983 DOI: 10.1021/Jacs.5B09970  0.47
2015 Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, Århem P, Hökfelt T, Fried K, Shi TJ. G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Molecular Pain. 11: 44. PMID 26199148 DOI: 10.1186/S12990-015-0044-Z  0.747
2015 Sahlholm K, Sijbesma JW, Maas B, Kwizera C, Marcellino D, Ramakrishnan NK, Dierckx RA, Elsinga PH, van Waarde A. Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses. Psychopharmacology. 232: 3443-53. PMID 26159455 DOI: 10.1007/S00213-015-3997-8  0.425
2014 Sahlholm K, Marcellino D, Nilsson J, Ögren SO, Fuxe K, Ã…rhem P. Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 149-55. PMID 24074141 DOI: 10.1017/S1461145713000801  0.758
2014 Sahlholm K, Zeberg H, Marcellino D, Nilsson J, Ogren S, Fuxe K, Arhem P. P.3.c.010 The fast-off hypothesis revisited: on-rates and reversibility of antipsychotic antagonism at the D2 receptor European Neuropsychopharmacology. 24: S520. DOI: 10.1016/S0924-977X(14)70833-8  0.796
2013 Sahlholm K, Ã…rhem P, Fuxe K, Marcellino D. The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Molecular Psychiatry. 18: 12-4. PMID 22349783 DOI: 10.1038/Mp.2012.3  0.712
2013 Sahlholm K, Frisk S, Nilsson J, Marcellino D, Fuxe K, Ove Ögren S, Århem P. Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics Biophysical Journal. 104: 26a. DOI: 10.1016/J.Bpj.2012.11.183  0.771
2012 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage sensitivities and deactivation kinetics of histamine H₃ and Hâ‚„ receptors. Biochimica Et Biophysica Acta. 1818: 3081-9. PMID 22885137 DOI: 10.1016/J.Bbamem.2012.07.027  0.749
2012 Sahlholm K, Frisk S, Marcellino D, Nilsson J, Fuxe K, Århem P. P.1.030 Antagonist dissociation from dopamine D2 receptors: studies using a time-resolved ion channel activation assay European Neuropsychopharmacology. 22: S29. DOI: 10.1016/S0924-977X(12)70031-7  0.773
2012 Sahlholm K, Frisk S, Nilsson J, Marcellino D, Fuxe Peter Århem K. Dopamine D2 Receptor Antagonist Unbinding Rates Investigated using a Time-Resolved Ion Channel Activation Assay Biophysical Journal. 102: 517a. DOI: 10.1016/J.Bpj.2011.11.2829  0.675
2011 Sahlholm K. The role of RGS protein in agonist-dependent relaxation of GIRK currents in Xenopus oocytes. Biochemical and Biophysical Research Communications. 415: 509-14. PMID 22068057 DOI: 10.1016/J.Bbrc.2011.10.106  0.4
2011 Sahlholm K, Barchad-Avitzur O, Marcellino D, Gómez-Soler M, Fuxe K, Ciruela F, Arhem P. Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands. Neuropharmacology. 61: 937-49. PMID 21752340 DOI: 10.1016/J.Neuropharm.2011.06.022  0.799
2011 Sahlholm K, Frisk S, Fuxe K, Århem P. P.3.d.010 Investigation of antagonist unbinding from dopamine D2 receptors using a real-time ion channel activation assay European Neuropsychopharmacology. 21: S511-S512. DOI: 10.1016/S0924-977X(11)70832-X  0.699
2010 Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R. Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. The European Journal of Neuroscience. 32: 1265-77. PMID 20846323 DOI: 10.1111/J.1460-9568.2010.07356.X  0.591
2010 Marcellino D, Navarro G, Sahlholm K, Nilsson J, Agnati LF, Canela EI, Lluís C, Ã…rhem P, Franco R, Fuxe K. Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. Biochemical and Biophysical Research Communications. 394: 988-92. PMID 20307491 DOI: 10.1016/J.Bbrc.2010.03.104  0.764
2010 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Århem P. Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity Biophysical Journal. 98: 290a. DOI: 10.1016/J.Bpj.2009.12.1581  0.767
2010 Nilsson J, Madeja M, Sahlholm K, Arhem P. Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine Biophysical Journal. 98: 213a. DOI: 10.1016/J.Bpj.2009.12.1149  0.66
2009 Johanna N, Ullman H, Sahlholm K, Arhem P. Role of Aromatic Residues for Local Anaesthetic Binding to Ion Channels Biophysical Journal. 96: 561a-562a. DOI: 10.1016/J.Bpj.2008.12.3683  0.595
2009 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Århem P. Differential Voltage-sensitivities Of Agonists At The Dopamine D2S Receptor Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.1986  0.668
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific. Biochemical and Biophysical Research Communications. 377: 1216-21. PMID 18983826 DOI: 10.1016/J.Bbrc.2008.10.117  0.763
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Differential voltage-sensitivity of D2-like dopamine receptors. Biochemical and Biophysical Research Communications. 374: 496-501. PMID 18652803 DOI: 10.1016/J.Bbrc.2008.07.052  0.766
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes. European Journal of Pharmacology. 591: 52-8. PMID 18582456 DOI: 10.1016/J.Ejphar.2008.06.029  0.727
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage-dependence of the human dopamine D2 receptor. Synapse (New York, N.Y.). 62: 476-80. PMID 18361445 DOI: 10.1002/Syn.20509  0.781
2008 Århem P, Sahlholm K, Nilsson J. Mechanisms of Anaesthesia: A Role for Voltage-Gated K Channels? Anaesthesia Science. 117-127. DOI: 10.1002/9780470755297.ch9  0.614
2007 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. European Journal of Pharmacology. 567: 206-10. PMID 17537431 DOI: 10.1016/J.Ejphar.2007.04.032  0.726
2005 Persson AS, Klement G, Almgren M, Sahlholm K, Nilsson J, Petersson S, Arhem P, Schalling M, Lavebratt C. A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction. Bmc Neuroscience. 6: 65. PMID 16305740 DOI: 10.1186/1471-2202-6-65  0.739
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