Isaac Chiu - Publications

Affiliations: 
Children's Hospital/Harvard Medical School, Boston, MA, United States 
Area:
Pain, Neuro-immune interactions

50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, ... ... Chiu IM, et al. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. PMID 36243004 DOI: 10.1016/j.cell.2022.09.024  0.771
2022 Udit S, Blake K, Chiu IM. Somatosensory and autonomic neuronal regulation of the immune response. Nature Reviews. Neuroscience. PMID 34997214 DOI: 10.1038/s41583-021-00555-4  0.703
2021 Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, ... ... Chiu IM, et al. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2 DRG sensory neurons. Nature Neuroscience. PMID 34931070 DOI: 10.1038/s41593-021-00973-8  0.772
2021 Yang NJ, Neel DV, Deng L, Heyang M, Kennedy-Curran A, Tong VS, Park JM, Chiu IM. Nociceptive Sensory Neurons Mediate Inflammation Induced by Edema Toxin. Frontiers in Immunology. 12: 642373. PMID 34413846 DOI: 10.3389/fimmu.2021.642373  0.774
2021 Lin T, Quellier D, Lamb J, Voisin T, Baral P, Bock F, Schönberg A, Mirchev R, Pier G, Chiu I, Gadjeva M. Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. Plos Pathogens. 17: e1009557. PMID 33956874 DOI: 10.1371/journal.ppat.1009557  0.779
2021 Yan Y, Ramanan D, Rozenberg M, McGovern K, Rastelli D, Vijaykumar B, Yaghi O, Voisin T, Mosaheb M, Chiu I, Itzkovitz S, Rao M, Mathis D, Benoist C. Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut. Immunity. 54: 499-513.e5. PMID 33691135 DOI: 10.1016/j.immuni.2021.02.002  0.411
2021 Jacobson A, Yang D, Vella M, Chiu IM. The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes. Mucosal Immunology. PMID 33542493 DOI: 10.1038/s41385-020-00368-1  0.781
2021 Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, ... Chiu IM, et al. Gut-licensed IFNγ NK cells drive LAMP1TRAIL anti-inflammatory astrocytes. Nature. PMID 33408417 DOI: 10.1038/s41586-020-03116-4  0.648
2021 Lagomarsino VN, Kostic AD, Chiu IM. Mechanisms of microbial-neuronal interactions in pain and nociception. Neurobiology of Pain (Cambridge, Mass.). 9: 100056. PMID 33392418 DOI: 10.1016/j.ynpai.2020.100056  0.432
2020 Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. PMID 33098765 DOI: 10.1016/j.immuni.2020.10.001  0.348
2020 Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. PMID 32102913 DOI: 10.1073/Pnas.1922559117  0.728
2020 Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. PMID 31969699 DOI: 10.1038/S41586-020-1935-3  0.71
2019 Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, ... ... Chiu IM, et al. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. PMID 31813624 DOI: 10.1016/J.Cell.2019.11.014  0.776
2019 Pinho-Ribeiro FA, Chiu IM. Nociceptor nerves set the stage for skin immunity. Cell Research. PMID 31619764 DOI: 10.1038/s41422-019-0240-x  0.613
2019 Blake KJ, Jiang XR, Chiu IM. Neuronal Regulation of Immunity in the Skin and Lungs. Trends in Neurosciences. PMID 31213389 DOI: 10.1016/j.tins.2019.05.005  0.685
2019 Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nature Reviews. Immunology. PMID 30874629 DOI: 10.1038/s41577-019-0147-2  0.8
2018 Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nature Medicine. PMID 30013196 DOI: 10.1038/S41591-018-0093-8  0.721
2018 Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. PMID 29754819 DOI: 10.1016/j.cell.2018.04.006  0.825
2018 Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and γδ T cell responses in bacterial lung infections and lethal pneumonia. Nature Medicine. PMID 29505031 DOI: 10.1038/Nm.4501  0.787
2018 Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nature Communications. 9: 37. PMID 29295977 DOI: 10.1038/S41467-017-02448-6  0.776
2018 Yang N, Liu SM, Marlin S, Lewandowska A, Heyang M, Voisin T, Tripathi V, Kalinichev M, Chaddock J, Collier RJ, Foster K, Chiu I. Chimeras of anthrax toxin and botulinum neurotoxin as novel analgesic proteins Toxicon. 156: S118. DOI: 10.1016/J.Toxicon.2018.11.282  0.674
2017 Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, ... ... Chiu IM, et al. Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. PMID 29143821 DOI: 10.1038/Nature24480  0.69
2017 Chavan SS, Ma P, Chiu IM. Neuro-immune Interactions in Inflammation and Host Defense: Implications for Transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28941325 DOI: 10.1111/ajt.14515  0.768
2017 Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, ... ... Chiu IM, et al. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. PMID 28902842 DOI: 10.1038/Nature24029  0.731
2017 Voisin T, Bouvier A, Chiu IM. Neuro-immune interactions in allergic diseases: novel targets for therapeutics. International Immunology. 29: 247-261. PMID 28814067 DOI: 10.1093/intimm/dxx040  0.421
2017 Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. PMID 28262351 DOI: 10.1016/J.Cell.2017.02.009  0.784
2017 Lai NY, Mills K, Chiu IM. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. Journal of Internal Medicine. PMID 28155242 DOI: 10.1111/joim.12591  0.44
2017 Chiu IM. Infection, Pain, and Itch. Neuroscience Bulletin. PMID 28144843 DOI: 10.1007/s12264-017-0098-1  0.442
2017 Yang NJ, Chiu IM. Bacterial Signaling to the Nervous System via Toxins and Metabolites. Journal of Molecular Biology. PMID 28065740 DOI: 10.1016/j.jmb.2016.12.023  0.767
2016 Pinho-Ribeiro FA, Verri WA, Chiu IM. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends in Immunology. PMID 27793571 DOI: 10.1016/j.it.2016.10.001  0.75
2016 Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? Cell Host & Microbe. 19: 755-9. PMID 27281567 DOI: 10.1016/j.chom.2016.05.010  0.82
2016 Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 157: 1192-3. PMID 27183444 DOI: 10.1097/j.pain.0000000000000559  0.71
2015 Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598697 DOI: 10.1073/Pnas.1501372112  0.76
2015 Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, et al. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. PMID 26119026 DOI: 10.1016/J.Neuron.2015.06.007  0.783
2015 Lin CH, Hsiao YH, Chang HC, Yeh CF, He CK, Salm EM, Chen C, Chiu IM, Hsu CH. A microfluidic dual-well device for high-throughput single-cell capture and culture. Lab On a Chip. 15: 2928-38. PMID 26060987 DOI: 10.1039/c5lc00541h  0.455
2015 Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, et al. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 4: e06720. PMID 25658835 DOI: 10.7554/eLife.06720  0.78
2015 Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, et al. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nature Neuroscience. 18: 17-24. PMID 25420066 DOI: 10.1038/Nn.3886  0.788
2014 Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, et al. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 3. PMID 25525749 DOI: 10.7554/Elife.04660  0.796
2014 Zhao F, Heesters BA, Chiu I, Gao Y, Shi J, Zhou N, Carroll MC, Xu B. L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials. Organic & Biomolecular Chemistry. 12: 6816-9. PMID 25078446 DOI: 10.1039/C4Ob01362J  0.503
2013 Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 501: 52-7. PMID 23965627 DOI: 10.1038/Nature12479  0.828
2013 Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Reports. 4: 385-401. PMID 23850290 DOI: 10.1016/J.Celrep.2013.06.018  0.774
2012 Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nature Neuroscience. 15: 1063-7. PMID 22837035 DOI: 10.1038/nn.3144  0.578
2011 Wang TC, Chiu H, Chang YJ, Hsu TY, Chiu IM, Chen L. The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons. Plos One. 6: e26433. PMID 22028877 DOI: 10.1371/journal.pone.0026433  0.325
2010 Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovascular Research. 87: 618-27. PMID 20462867 DOI: 10.1093/Cvr/Cvq141  0.518
2010 Kim SS, Ye C, Kumar P, Chiu I, Subramanya S, Wu H, Shankar P, Manjunath N. Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 993-1001. PMID 20216529 DOI: 10.1038/Mt.2010.27  0.333
2009 Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 20960-5. PMID 19933335 DOI: 10.1073/Pnas.0911405106  0.776
2008 Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proceedings of the National Academy of Sciences of the United States of America. 105: 17913-8. PMID 18997009 DOI: 10.1073/Pnas.0804610105  0.564
2006 Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. The Journal of Cell Biology. 175: 209-15. PMID 17060494 DOI: 10.1083/Jcb.200606016  0.438
2006 Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. The Journal of Experimental Medicine. 203: 141-52. PMID 16390934 DOI: 10.1084/Jem.20050390  0.516
2004 Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 101: 3886-91. PMID 14999103 DOI: 10.1073/Pnas.0400347101  0.527
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