Mel B. Feany, MD PhD - Publications

Affiliations: 
Pathology Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States 
 Massachusetts General Hospital, Boston, MA 
 University of Wisconsin, Madison, Madison, WI 
Area:
In our laboratory we have created fruit fly models of human neurological diseases, including Alzheimer's disease, Parkinson's disease, and a number of less common disorders
Website:
http://feany-lab.bwh.harvard.edu/

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bardai FH, Ordonez DG, Bailey RM, Hamm M, Lewis J, Feany MB. Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. Plos Biology. 16: e2006265. PMID 30571694 DOI: 10.1371/journal.pbio.2006265  1
2018 Wang L, Xia J, Li J, Hagemann TL, Jones JR, Fraenkel E, Weitz DA, Zhang SC, Messing A, Feany MB. Tissue and cellular rigidity and mechanosensitive signaling activation in Alexander disease. Nature Communications. 9: 1899. PMID 29765022 DOI: 10.1038/s41467-018-04269-7  1
2017 Ordonez DG, Lee MK, Feany MB. α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton. Neuron. PMID 29249285 DOI: 10.1016/j.neuron.2017.11.036  0.64
2017 Bardai FH, Wang L, Mutreja Y, Yenjerla M, Gamblin TC, Feany MB. A conserved cytoskeletal signaling cascade mediates neurotoxicity of FTDP-17 tau mutations in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29138281 DOI: 10.1523/JNEUROSCI.1550-17.2017  0.96
2016 Etchegaray JI, Elguero EJ, Tran JA, Sinatra V, Feany MB, McCall K. Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3170-83. PMID 26985028 DOI: 10.1523/JNEUROSCI.1912-15.2016  1
2016 Wang L, Hagemann TL, Messing A, Feany MB. An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1445-55. PMID 26843629 DOI: 10.1523/JNEUROSCI.0256-15.2016  1
2015 Frost B, Bardai FH, Feany MB. Lamin Dysfunction Mediates Neurodegeneration in Tauopathies. Current Biology : Cb. PMID 26725200 DOI: 10.1016/j.cub.2015.11.039  1
2015 Wang L, Hagemann TL, Kalwa H, Michel T, Messing A, Feany MB. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nature Communications. 6: 8966. PMID 26608817 DOI: 10.1038/ncomms9966  1
2015 Frost B, Götz J, Feany MB. Connecting the dots between tau dysfunction and neurodegeneration. Trends in Cell Biology. 25: 46-53. PMID 25172552 DOI: 10.1016/j.tcb.2014.07.005  1
2014 Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nature Neuroscience. 17: 357-66. PMID 24464041 DOI: 10.1038/nn.3639  1
2014 Shulman JM, Imboywa S, Giagtzoglou N, Powers MP, Hu Y, Devenport D, Chipendo P, Chibnik LB, Diamond A, Perrimon N, Brown NH, De Jager PL, Feany MB. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Human Molecular Genetics. 23: 870-7. PMID 24067533 DOI: 10.1093/hmg/ddt478  1
2013 Hill-Burns EM, Singh N, Ganguly P, Hamza TH, Montimurro J, Kay DM, Yearout D, Sheehan P, Frodey K, McLear JA, Feany MB, Hanes SD, Wolfgang WJ, Zabetian CP, Factor SA, et al. A genetic basis for the variable effect of smoking/nicotine on Parkinson's disease. The Pharmacogenomics Journal. 13: 530-7. PMID 23032990 DOI: 10.1038/tpj.2012.38  1
2012 Ryan EL, DuBoff B, Feany MB, Fridovich-Keil JL. Mediators of a long-term movement abnormality in a Drosophila melanogaster model of classic galactosemia. Disease Models & Mechanisms. 5: 796-803. PMID 22736462 DOI: 10.1242/dmm.009050  1
2012 Khurana V, Merlo P, DuBoff B, Fulga TA, Sharp KA, Campbell SD, Götz J, Feany MB. A neuroprotective role for the DNA damage checkpoint in tauopathy. Aging Cell. 11: 360-2. PMID 22181010 DOI: 10.1111/j.1474-9726.2011.00778.x  1
2011 Wang L, Colodner KJ, Feany MB. Protein misfolding and oxidative stress promote glial-mediated neurodegeneration in an Alexander disease model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2868-77. PMID 21414908 DOI: 10.1523/JNEUROSCI.3410-10.2011  1
2011 Shulman JM, Chipendo P, Chibnik LB, Aubin C, Tran D, Keenan BT, Kramer PL, Schneider JA, Bennett DA, Feany MB, De Jager PL. Functional screening of Alzheimer pathology genome-wide association signals in Drosophila. American Journal of Human Genetics. 88: 232-8. PMID 21295279 DOI: 10.1016/j.ajhg.2011.01.006  1
2010 Colodner KJ, Feany MB. Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16102-13. PMID 21123557 DOI: 10.1523/JNEUROSCI.2491-10.2010  1
2010 Loewen CA, Feany MB. The unfolded protein response protects from tau neurotoxicity in vivo. Plos One. 5. PMID 20927324 DOI: 10.1371/journal.pone.0013084  1
2010 Khurana V, Elson-Schwab I, Fulga TA, Sharp KA, Loewen CA, Mulkearns E, Tyynelä J, Scherzer CR, Feany MB. Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo. Plos Genetics. 6: e1001026. PMID 20664788 DOI: 10.1371/journal.pgen.1001026  1
2009 Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. The Journal of Clinical Investigation. 119: 3257-65. PMID 19855133 DOI: 10.1172/JCI39088  1
2009 McFarland NR, Fan Z, Xu K, Schwarzschild MA, Feany MB, Hyman BT, McLean PJ. Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 68: 515-24. PMID 19525899 DOI: 10.1097/NEN.0b013e3181a24b53  1
2009 Zhang S, Feany MB, Saraswati S, Littleton JT, Perrimon N. Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model. Disease Models & Mechanisms. 2: 247-66. PMID 19380309 DOI: 10.1242/dmm.000653  1
2009 Cullen V, Lindfors M, Ng J, Paetau A, Swinton E, Kolodziej P, Boston H, Saftig P, Woulfe J, Feany MB, Myllykangas L, Schlossmacher MG, Tyynelä J. Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo. Molecular Brain. 2: 5. PMID 19203374 DOI: 10.1186/1756-6606-2-5  1
2009 Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings of the National Academy of Sciences of the United States of America. 106: 1392-7. PMID 19171884 DOI: 10.1073/pnas.0813045106  1
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/JNEUROSCI.3072-08.2008  1
2007 Steinhilb ML, Dias-Santagata D, Fulga TA, Felch DL, Feany MB. Tau phosphorylation sites work in concert to promote neurotoxicity in vivo. Molecular Biology of the Cell. 18: 5060-8. PMID 17928404 DOI: 10.1091/mbc.E07-04-0327  1
2007 Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317: 516-9. PMID 17588900 DOI: 10.1126/science.1143780  1
2007 Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT. Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. The American Journal of Pathology. 170: 1725-38. PMID 17456777 DOI: 10.2353/ajpath.2007.061232  1
2007 Steinhilb ML, Dias-Santagata D, Mulkearns EE, Shulman JM, Biernat J, Mandelkow EM, Feany MB. S/P and T/P phosphorylation is critical for tau neurotoxicity in Drosophila. Journal of Neuroscience Research. 85: 1271-8. PMID 17335084 DOI: 10.1002/jnr.21232  1
2007 Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology. 9: 139-48. PMID 17187063 DOI: 10.1038/ncb1528  1
2007 Dias-Santagata D, Fulga TA, Duttaroy A, Feany MB. Oxidative stress mediates tau-induced neurodegeneration in Drosophila. The Journal of Clinical Investigation. 117: 236-45. PMID 17173140 DOI: 10.1172/JCI28769  1
2007 Khurana V, Feany MB. Connecting cell-cycle activation to neurodegeneration in Drosophila. Biochimica Et Biophysica Acta. 1772: 446-56. PMID 17141486 DOI: 10.1016/j.bbadis.2006.10.007  1
2006 Gavin BA, Dolph MJ, Deleault NR, Geoghegan JC, Khurana V, Feany MB, Dolph PJ, Supattapone S. Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12408-14. PMID 17135402 DOI: 10.1523/JNEUROSCI.3372-06.2006  1
2006 Kontopoulos E, Parvin JD, Feany MB. Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Human Molecular Genetics. 15: 3012-23. PMID 16959795 DOI: 10.1093/hmg/ddl243  1
2006 Khurana V, Lu Y, Steinhilb ML, Oldham S, Shulman JM, Feany MB. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Current Biology : Cb. 16: 230-41. PMID 16461276 DOI: 10.1016/j.cub.2005.12.042  1
2005 Khurana V, Fulga TA, Feany MB. Senseless makes sense for spinocerebellar ataxia-1. Nature Neuroscience. 8: 1422-4. PMID 16251977 DOI: 10.1038/nn1105-1422  1
2005 Myllykangas L, Tyynelä J, Page-McCaw A, Rubin GM, Haltia MJ, Feany MB. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses. Neurobiology of Disease. 19: 194-9. PMID 15837574 DOI: 10.1016/j.nbd.2004.12.019  1
2005 Colodner KJ, Montana RA, Anthony DC, Folkerth RD, De Girolami U, Feany MB. Proliferative potential of human astrocytes. Journal of Neuropathology and Experimental Neurology. 64: 163-9. PMID 15751231  1
2004 Scherzer CR, Feany MB. Yeast genetics targets lipids in Parkinson's disease. Trends in Genetics : Tig. 20: 273-7. PMID 15219388 DOI: 10.1016/j.tig.2004.05.005  1
2003 Feany MB, La Spada AR. Polyglutamines stop traffic: axonal transport as a common target in neurodegenerative diseases. Neuron. 40: 1-2. PMID 14527425 DOI: 10.1016/S0896-6273(03)00600-7  1
2003 Scherzer CR, Jensen RV, Gullans SR, Feany MB. Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease. Human Molecular Genetics. 12: 2457-66. PMID 12915459 DOI: 10.1093/hmg/ddg265  1
2003 Shulman JM, Shulman LM, Weiner WJ, Feany MB. From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease. Current Opinion in Neurology. 16: 443-9. PMID 12869801 DOI: 10.1097/01.wco.0000084220.82329.60  1
2003 Deleault NR, Dolph PJ, Feany MB, Cook ME, Nishina K, Harris DA, Supattapone S. Post-transcriptional suppression of pathogenic prion protein expression in Drosophila neurons. Journal of Neurochemistry. 85: 1614-23. PMID 12787080 DOI: 10.1046/j.1471-4159.2003.01819.x  1
2003 Feany MB, Pallanck LJ. Parkin: a multipurpose neuroprotective agent? Neuron. 38: 13-6. PMID 12691660 DOI: 10.1016/S0896-6273(03)00201-0  1
2003 Greene JC, Whitworth AJ, Kuo I, Andrews LA, Feany MB, Pallanck LJ. Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants. Proceedings of the National Academy of Sciences of the United States of America. 100: 4078-83. PMID 12642658 DOI: 10.1073/pnas.0737556100  1
2001 Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science (New York, N.Y.). 293: 711-4. PMID 11408621 DOI: 10.1126/science.1062382  1
2001 Feany MB, Anthony DC, Frosch MP, Zane W, De Girolami U. August 2000: Two cases with necrosis and hemorrhage in the putamen and white matter. Brain Pathology (Zurich, Switzerland). 11: 121-2, 125. PMID 11145199  1
2000 Feany MB, Bender WW. A Drosophila model of Parkinson's disease. Nature. 404: 394-8. PMID 10746727 DOI: 10.1038/35006074  1
1998 Feany MB, Anthony DC, Fletcher CD. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology. 32: 405-10. PMID 9639114 DOI: 10.1046/j.1365-2559.1998.00419.x  1
1996 Feany MB, Dickson DW. Neurodegenerative disorders with extensive tau pathology: a comparative study and review. Annals of Neurology. 40: 139-48. PMID 8773594 DOI: 10.1002/ana.410400204  1
1996 Feany MB, Mattiace LA, Dickson DW. Neuropathologic overlap of progressive supranuclear palsy, Pick's disease and corticobasal degeneration. Journal of Neuropathology and Experimental Neurology. 55: 53-67. PMID 8558172  1
1995 Feany MB, Dickson DW. Widespread cytoskeletal pathology characterizes corticobasal degeneration. The American Journal of Pathology. 146: 1388-96. PMID 7778678  1
1993 Feany MB, Buckley KM. The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts. Nature. 364: 537-40. PMID 8166886 DOI: 10.1038/364537a0  1
1993 Feany MB, Yee AG, Delvy ML, Buckley KM. The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts. The Journal of Cell Biology. 123: 575-84. PMID 7901222 DOI: 10.1083/jcb.123.3.575  1
1992 Feany MB, Lee S, Edwards RH, Buckley KM. The synaptic vesicle protein SV2 is a novel type of transmembrane transporter. Cell. 70: 861-7. PMID 1355409 DOI: 10.1016/0092-8674(92)90319-8  1
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