Gregory L. Holmes - Publications

Neurology Dartmouth College, Hanover, NH, United States 
 University of Vermont, Burlington, VT, United States 
epilepsy, pediatrics

245 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kloc ML, Velasquez F, Niedecker R, Barry JM, Holmes GL. Disruption of Hippocampal Rhythms via Optogenetic Stimulation During the Critical Period for Memory Development Impairs Spatial Cognition. Brain Stimulation. PMID 32871261 DOI: 10.1016/j.brs.2020.08.011  1
2020 Mouchati PR, Kloc ML, Holmes GL, White SL, Barry JM. Optogenetic "low-theta" pacing of the septohippocampal circuit is sufficient for spatial goal finding and is influenced by behavioral state and cognitive demand. Hippocampus. PMID 32710688 DOI: 10.1002/hipo.23248  1
2020 Barry JM, Mahoney JM, Holmes GL. Coordination of hippocampal theta and gamma oscillations relative to spatial active avoidance reflects cognitive outcome after febrile status epilepticus. Behavioral Neuroscience. PMID 32628031 DOI: 10.1037/bne0000388  1
2019 Zakharov A, Chernova K, Burkhanova G, Holmes GL, Khazipov R. Segregation of seizures and spreading depolarization across cortical layers. Epilepsia. PMID 31755112 DOI: 10.1111/epi.16390  1
2019 Baram TZ, Donato F, Holmes GL. Construction and disruption of spatial memory networks during development. Learning & Memory (Cold Spring Harbor, N.Y.). 26: 206-218. PMID 31209115 DOI: 10.1101/lm.049239.118  0.76
2019 Mouchati PR, Barry JM, Holmes GL. Functional brain connectivity in a rodent seizure model of autistic-like behavior. Epilepsy & Behavior : E&B. 95: 87-94. PMID 31030078 DOI: 10.1016/j.yebeh.2019.03.046  1
2019 Mott SH, Morse RP, Burroughs SA, Buckley AW, Farmer CA, Thurm AE, Swedo SE, Krag AL, Holmes GL. Functional brain connectivity in electrical status epilepticus in sleep. Epileptic Disorders : International Epilepsy Journal With Videotape. PMID 30767900 DOI: 10.1684/epd.2019.1027  0.72
2019 Valeeva G, Janackova S, Nasretdinov A, Rychkova V, Makarov R, Holmes GL, Khazipov R, Lenck-Santini PP. Emergence of Coordinated Activity in the Developing Entorhinal-Hippocampal Network. Cerebral Cortex (New York, N.Y. : 1991). 29: 906-920. PMID 30535003 DOI: 10.1093/cercor/bhy309  1
2018 Hernan AE, Mahoney JM, Curry W, Richard G, Lucas MM, Massey A, Holmes GL, Scott RC. Environmental enrichment normalizes hippocampal timing coding in a malformed hippocampus. Plos One. 13: e0191488. PMID 29394267 DOI: 10.1371/journal.pone.0191488  1
2017 Johnson AC, Hammer ES, Sakkaki S, Tremble SM, Holmes GL, Cipolla MJ. Inhibition of blood-brain barrier efflux transporters promotes seizure in pregnant rats: Role of circulating factors. Brain, Behavior, and Immunity. PMID 28739514 DOI: 10.1016/j.bbi.2017.07.017  0.76
2017 Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y, Holmes GL, Baram TZ. Enduring memory impairments provoked by developmental febrile seizures are mediated by functional and structural effects of neuronal restrictive silencing factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275159 DOI: 10.1523/JNEUROSCI.3748-16.2017  1
2017 Fedoriuk M, Isaev D, Krishtal O, Holmes GL, Isaeva E. Effects of protease-activated receptor 1 inhibition on anxiety and fear following status epilepticus. Epilepsy & Behavior : E&B. 67: 66-69. PMID 28088683 DOI: 10.1016/j.yebeh.2016.11.003  0.72
2016 Blumberg BJ, Flynn SP, Barriere SJ, Mouchati PR, Scott RC, Holmes GL, Barry JM. Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: the influence of speed and implications for cognitive enhancement. Physiological Reports. 4. PMID 27923975 DOI: 10.14814/phy2.13048  1
2016 Barry JM, Holmes GL. Why Are Children With Epileptic Encephalopathies Encephalopathic? Journal of Child Neurology. PMID 27515946 DOI: 10.1177/0883073816662140  1
2016 Kleen JK, Testorf ME, Roberts DW, Scott RC, Jobst BJ, Holmes GL, Lenck-Santini PP. Oscillation Phase Locking and Late ERP Components of Intracranial Hippocampal Recordings Correlate to Patient Performance in a Working Memory Task. Frontiers in Human Neuroscience. 10: 287. PMID 27378885 DOI: 10.3389/fnhum.2016.00287  1
2016 Hernan AE, Holmes GL. Antiepileptic drug treatment strategies in neonatal epilepsy. Progress in Brain Research. 226: 179-93. PMID 27323943 DOI: 10.1016/bs.pbr.2016.03.011  1
2016 Barry JM, Sakkaki S, Barriere SJ, Patterson KP, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus. Ebiomedicine. 7: 175-190. PMID 27322471 DOI: 10.1016/j.ebiom.2016.03.039  1
2016 Massey AT, Lerner DK, Holmes GL, Scott RC, Hernan AE. ACTH Prevents Deficits in Fear Extinction Associated with Early Life Seizures. Frontiers in Neurology. 7: 65. PMID 27199888 DOI: 10.3389/fneur.2016.00065  1
2016 Barry JM, Tian C, Spinella A, Page M, Holmes GL. Spatial cognition following early-life seizures in rats: Performance deficits are dependent on task demands. Epilepsy & Behavior : E&B. 60: 1-6. PMID 27152463 DOI: 10.1016/j.yebeh.2016.03.032  1
2015 Buckley AW, Scott R, Tyler A, Mahoney JM, Thurm A, Farmer C, Swedo S, Burroughs SA, Holmes GL. State-Dependent Differences in Functional Connectivity in Young Children With Autism Spectrum Disorder. Ebiomedicine. 2: 1905-15. PMID 26844269 DOI: 10.1016/j.ebiom.2015.11.004  0.8
2015 Flynn SP, Barriere S, Scott RC, Lenck-Santini PP, Holmes GL. Correction: Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. Plos One. 10: e0136125. PMID 26275312 DOI: 10.1371/journal.pone.0136125  1
2015 Flynn SP, Barrier S, Scott RC, Lenck-Santini PP, Holmes GL. Status Epilepticus Induced Spontaneous Dentate Gyrus Spikes: In Vivo Current Source Density Analysis. Plos One. 10: e0132630. PMID 26148195 DOI: 10.1371/journal.pone.0132630  1
2015 Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. T2 relaxation time post febrile status epilepticus predicts cognitive outcome. Experimental Neurology. 269: 242-52. PMID 25939697 DOI: 10.1016/j.expneurol.2015.04.015  1
2015 Holmes GL. Cognitive impairment in epilepsy: the role of network abnormalities. Epileptic Disorders : International Epilepsy Journal With Videotape. 17: 101-16. PMID 25905906 DOI: 10.1684/epd.2015.0739  1
2015 Isaev D, Lushnikova I, Lunko O, Zapukhliak O, Maximyuk O, Romanov A, Skibo GG, Tian C, Holmes GL, Isaeva E. Contribution of protease-activated receptor 1 in status epilepticus-induced epileptogenesis. Neurobiology of Disease. 78: 68-76. PMID 25843668 DOI: 10.1016/j.nbd.2015.03.026  0.72
2015 Savotchenko A, Romanov A, Isaev D, Maximyuk O, Sydorenko V, Holmes GL, Isaeva E. Neuraminidase inhibition primes short-term depression and suppresses long-term potentiation of synaptic transmission in the rat hippocampus. Neural Plasticity. 2015: 908190. PMID 25802763 DOI: 10.1155/2015/908190  0.72
2015 Holmes GL, Tian C, Hernan AE, Flynn S, Camp D, Barry J. Alterations in sociability and functional brain connectivity caused by early-life seizures are prevented by bumetanide. Neurobiology of Disease. 77: 204-19. PMID 25766676 DOI: 10.1016/j.nbd.2015.02.015  1
2015 Isaeva E, Romanov A, Holmes GL, Isaev D. Status epilepticus results in region-specific alterations in seizure susceptibility along the hippocampal longitudinal axis. Epilepsy Research. 110: 166-70. PMID 25616469 DOI: 10.1016/j.eplepsyres.2014.12.009  1
2014 Khan OI, Azevedo CJ, Hartshorn AL, Montanye JT, Gonzalez JC, Natola MA, Surgenor SD, Morse RP, Nordgren RE, Bujarski KA, Holmes GL, Jobst BC, Scott RC, Thadani VM. A comparison of continuous video-EEG monitoring and 30-minute EEG in an ICU. Epileptic Disorders : International Epilepsy Journal With Videotape. 16: 439-48. PMID 25498516 DOI: 10.1684/epd.2014.0715  0.72
2014 Sitdikova G, Zakharov A, Janackova S, Gerasimova E, Lebedeva J, Inacio AR, Zaynutdinova D, Minlebaev M, Holmes GL, Khazipov R. Isoflurane suppresses early cortical activity. Annals of Clinical and Translational Neurology. 1: 15-26. PMID 25356379 DOI: 10.1002/acn3.16  1
2014 Titiz AS, Mahoney JM, Testorf ME, Holmes GL, Scott RC. Cognitive impairment in temporal lobe epilepsy: role of online and offline processing of single cell information. Hippocampus. 24: 1129-45. PMID 24799359 DOI: 10.1002/hipo.22297  1
2014 Burroughs SA, Morse RP, Mott SH, Holmes GL. Brain connectivity in West syndrome. Seizure. 23: 576-9. PMID 24794162 DOI: 10.1016/j.seizure.2014.03.016  1
2014 Hernan AE, Alexander A, Lenck-Santini PP, Scott RC, Holmes GL. Attention deficit associated with early life interictal spikes in a rat model is improved with ACTH. Plos One. 9: e89812. PMID 24587054 DOI: 10.1371/journal.pone.0089812  1
2014 Victorson D, Cavazos JE, Holmes GL, Reder AT, Wojna V, Nowinski C, Miller D, Buono S, Mueller A, Moy C, Cella D. Validity of the Neurology Quality-of-Life (Neuro-QoL) measurement system in adult epilepsy. Epilepsy & Behavior : E&B. 31: 77-84. PMID 24361767 DOI: 10.1016/j.yebeh.2013.11.008  1
2014 Hernan AE, Alexander A, Jenks KR, Barry J, Lenck-Santini PP, Isaeva E, Holmes GL, Scott RC. Focal epileptiform activity in the prefrontal cortex is associated with long-term attention and sociability deficits. Neurobiology of Disease. 63: 25-34. PMID 24269731 DOI: 10.1016/j.nbd.2013.11.012  1
2014 Nair S, Morse RP, Mott SH, Burroughs SA, Holmes GL. Transitory effect of spike and spike-and-wave discharges on EEG power in children. Brain & Development. 36: 505-9. PMID 23911277 DOI: 10.1016/j.braindev.2013.07.004  1
2013 Robbins AA, Fox SE, Holmes GL, Scott RC, Barry JM. Short duration waveforms recorded extracellularly from freely moving rats are representative of axonal activity. Frontiers in Neural Circuits. 7: 181. PMID 24348338 DOI: 10.3389/fncir.2013.00181  1
2013 Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Authors' response to letter by A. Mazarati. Epilepsia. 54: 2229-30. PMID 24304440 DOI: 10.1111/epi.12414  0.44
2013 Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 54: 44-60. PMID 23909853 DOI: 10.1111/epi.12298  0.44
2013 Richard GR, Titiz A, Tyler A, Holmes GL, Scott RC, Lenck-Santini PP. Speed modulation of hippocampal theta frequency correlates with spatial memory performance. Hippocampus. 23: 1269-79. PMID 23832676 DOI: 10.1002/hipo.22164  1
2013 Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, Jobst BC. Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology. 81: 18-24. PMID 23685931 DOI: 10.1212/WNL.0b013e318297ee50  1
2013 Holmes GL. EEG abnormalities as a biomarker for cognitive comorbidities in pharmacoresistant epilepsy. Epilepsia. 54: 60-2. PMID 23646973 DOI: 10.1111/epi.12186  1
2013 Isaeva E, Isaev D, Holmes GL. Alteration of synaptic plasticity by neonatal seizures in rat somatosensory cortex. Epilepsy Research. 106: 280-3. PMID 23623846 DOI: 10.1016/j.eplepsyres.2013.03.011  1
2013 Dulac O, Milh M, Holmes GL. Brain maturation and epilepsy. Handbook of Clinical Neurology. 111: 441-6. PMID 23622192 DOI: 10.1016/B978-0-444-52891-9.00047-6  1
2013 Dewolfe JL, Malow B, Huguenard J, Stickgold R, Bourgeois B, Holmes GL. Sleep and epilepsy: a summary of the 2011 merritt-putnam symposium. Epilepsy Currents / American Epilepsy Society. 13: 42-9. PMID 23447740 DOI: 10.5698/1535-7511-13.1.42  1
2013 Bender AC, Natola H, Ndong C, Holmes GL, Scott RC, Lenck-Santini PP. Focal Scn1a knockdown induces cognitive impairment without seizures. Neurobiology of Disease. 54: 297-307. PMID 23318929 DOI: 10.1016/j.nbd.2012.12.021  1
2013 Hernan AE, Holmes GL, Isaev D, Scott RC, Isaeva E. Altered short-term plasticity in the prefrontal cortex after early life seizures. Neurobiology of Disease. 50: 120-6. PMID 23064435 DOI: 10.1016/j.nbd.2012.10.007  1
2012 Scott RC, Holmes GL. Before epilepsy unfolds: opening up the potassium door in neonatal seizures. Nature Medicine. 18: 1624-5. PMID 23135515 DOI: 10.1038/nm.2987  1
2012 Holmes GL, Milh MD, Dulac O. Maturation of the human brain and epilepsy. Handbook of Clinical Neurology. 107: 135-43. PMID 22938967 DOI: 10.1016/B978-0-444-52898-8.00007-0  1
2012 Isaeva E, Hernan A, Isaev D, Holmes GL. Thrombin facilitates seizures through activation of persistent sodium current. Annals of Neurology. 72: 192-8. PMID 22926852 DOI: 10.1002/ana.23587  0.72
2012 Tyler AL, Mahoney JM, Richard GR, Holmes GL, Lenck-Santini PP, Scott RC. Functional network changes in hippocampal CA1 after status epilepticus predict spatial memory deficits in rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11365-76. PMID 22895719 DOI: 10.1523/JNEUROSCI.1516-12.2012  1
2012 Scott RC, Holmes GL. Febrile seizures and the wandering granule cell. Nature Medicine. 18: 1180-2. PMID 22869184 DOI: 10.1038/nm.2898  1
2012 Talnov AN, Isaeva E, Savotchenko AV, Dovgalets GV, Ochoa JG, Holmes GL, Isaev D. Electrolyte therapy reduces spike-and-wave discharges in the WAG/Rij rat model of absence epilepsy. Epilepsy & Behavior : E&B. 24: 399-402. PMID 22749239 DOI: 10.1016/j.yebeh.2012.05.018  0.72
2012 Bender AC, Morse RP, Scott RC, Holmes GL, Lenck-Santini PP. SCN1A mutations in Dravet syndrome: impact of interneuron dysfunction on neural networks and cognitive outcome. Epilepsy & Behavior : E&B. 23: 177-86. PMID 22341965 DOI: 10.1016/j.yebeh.2011.11.022  0.72
2012 Isaev D, Ivanchick G, Khmyz V, Isaeva E, Savrasova A, Krishtal O, Holmes GL, Maximyuk O. Surface charge impact in low-magnesium model of seizure in rat hippocampus. Journal of Neurophysiology. 107: 417-23. PMID 22031777 DOI: 10.1152/jn.00574.2011  0.72
2012 Holmes GL, Bender AC, Wu EX, Scott RC, Lenck-Santini PP, Morse RP. Maturation of EEG oscillations in children with sodium channel mutations. Brain & Development. 34: 469-77. PMID 21940124 DOI: 10.1016/j.braindev.2011.08.009  1
2011 Morse RP, Holmes GL. Education of a child neurologist: epilepsy and electroencephalography. Seminars in Pediatric Neurology. 18: 74-8. PMID 22036483 DOI: 10.1016/j.spen.2011.05.002  0.72
2011 Kleen JK, Wu EX, Holmes GL, Scott RC, Lenck-Santini PP. Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15397-406. PMID 22031886 DOI: 10.1523/JNEUROSCI.2196-11.2011  1
2011 Stern JM, Labiner DM, Gilliam FG, Penovich PE, Onofrey M, Eagan CA, Holmes GL. More effective assessment of adverse effects and comorbidities in epilepsy: results of a Phase II communication study. Epilepsy & Behavior : E&B. 22: 552-6. PMID 21967731 DOI: 10.1016/j.yebeh.2011.06.007  1
2011 Kleen JK, Sesqué A, Wu EX, Miller FA, Hernan AE, Holmes GL, Scott RC. Early-life seizures produce lasting alterations in the structure and function of the prefrontal cortex. Epilepsy & Behavior : E&B. 22: 214-9. PMID 21873119 DOI: 10.1016/j.yebeh.2011.07.022  1
2011 Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Effect of neuraminidase treatment on persistent epileptiform activity in the rat hippocampus. Pharmacological Reports : Pr. 63: 840-4. PMID 21857096  0.72
2011 Lucas MM, Lenck-Santini PP, Holmes GL, Scott RC. Impaired cognition in rats with cortical dysplasia: additional impact of early-life seizures. Brain : a Journal of Neurology. 134: 1684-93. PMID 21602270 DOI: 10.1093/brain/awr087  1
2011 Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, Holmes GL. Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia. 52: e12-5. PMID 21366554 DOI: 10.1111/j.1528-1167.2011.02988.x  1
2011 Scott RC, Richard GR, Holmes GL, Lenck-Santini PP. Maturational dynamics of hippocampal place cells in immature rats. Hippocampus. 21: 347-53. PMID 20865725 DOI: 10.1002/hipo.20789  1
2010 Isaeva E, Lushnikova I, Savrasova A, Skibo G, Holmes GL, Isaev D. Blockade of endogenous neuraminidase leads to an increase of neuronal excitability and activity-dependent synaptogenesis in the rat hippocampus. The European Journal of Neuroscience. 32: 1889-96. PMID 21044183 DOI: 10.1111/j.1460-9568.2010.07468.x  0.72
2010 Jobst BC, Williamson PD, Thadani VM, Gilbert KL, Holmes GL, Morse RP, Darcey TM, Duhaime AC, Bujarski KA, Roberts DW. Intractable occipital lobe epilepsy: clinical characteristics and surgical treatment. Epilepsia. 51: 2334-7. PMID 20662891 DOI: 10.1111/j.1528-1167.2010.02673.x  1
2010 Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. Infantile spasms: a U.S. consensus report. Epilepsia. 51: 2175-89. PMID 20608959 DOI: 10.1111/j.1528-1167.2010.02657.x  1
2010 Khan OI, Zhao Q, Miller F, Holmes GL. Interictal spikes in developing rats cause long-standing cognitive deficits. Neurobiology of Disease. 39: 362-71. PMID 20452427 DOI: 10.1016/j.nbd.2010.05.002  1
2010 Isaeva E, Isaev D, Savrasova A, Khazipov R, Holmes GL. Recurrent neonatal seizures result in long-term increases in neuronal network excitability in the rat neocortex. The European Journal of Neuroscience. 31: 1446-55. PMID 20384780 DOI: 10.1111/j.1460-9568.2010.07179.x  1
2010 Kleen JK, Holmes GL. Taming TLR4 may ease seizures. Nature Medicine. 16: 369-70. PMID 20376038 DOI: 10.1038/nm0410-369  1
2010 Kleen JK, Scott RC, Holmes GL, Lenck-Santini PP. Hippocampal interictal spikes disrupt cognition in rats. Annals of Neurology. 67: 250-7. PMID 20225290 DOI: 10.1002/ana.21896  1
2009 Isaeva E, Isaev D, Khazipov R, Holmes GL. Long-term suppression of GABAergic activity by neonatal seizures in rat somatosensory cortex. Epilepsy Research. 87: 286-9. PMID 19828295 DOI: 10.1016/j.eplepsyres.2009.09.011  1
2009 Gilliam F, Penovich PE, Eagan CA, Stern JM, Labiner DM, Onofrey M, Holmes GL, Mathis E, Cramer J. Conversations between community-based neurologists and patients with epilepsy: results of an observational linguistic study. Epilepsy & Behavior : E&B. 16: 315-20. PMID 19720567 DOI: 10.1016/j.yebeh.2009.07.039  1
2009 Karnam HB, Zhao Q, Shatskikh T, Holmes GL. Effect of age on cognitive sequelae following early life seizures in rats. Epilepsy Research. 85: 221-30. PMID 19395239 DOI: 10.1016/j.eplepsyres.2009.03.008  0.68
2009 Karnam HB, Zhou JL, Huang LT, Zhao Q, Shatskikh T, Holmes GL. Early life seizures cause long-standing impairment of the hippocampal map. Experimental Neurology. 217: 378-87. PMID 19345685 DOI: 10.1016/j.expneurol.2009.03.028  0.68
2009 Rogawski MA, Holmes GL. Nontraditional epilepsy treatment approaches. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 213-7. PMID 19332312 DOI: 10.1016/j.nurt.2009.02.002  1
2009 Lin H, Holmes GL, Kubie JL, Muller RU. Recurrent seizures induce a reversible impairment in a spatial hidden goal task. Hippocampus. 19: 817-27. PMID 19235227 DOI: 10.1002/hipo.20565  1
2009 Dubé CM, Zhou JL, Hamamura M, Zhao Q, Ring A, Abrahams J, McIntyre K, Nalcioglu O, Shatskih T, Baram TZ, Holmes GL. Cognitive dysfunction after experimental febrile seizures. Experimental Neurology. 215: 167-77. PMID 19000675 DOI: 10.1016/j.expneurol.2008.10.003  1
2009 Shatskikh T, Zhao Q, Zhou JL, Holmes GL. Effect of topiramate on cognitive function and single units from hippocampal place cells following status epilepticus. Epilepsy & Behavior : E&B. 14: 40-7. PMID 18929683 DOI: 10.1016/j.yebeh.2008.09.030  0.68
2008 Kleen JK, Holmes GL. Brain inflammation initiates seizures. Nature Medicine. 14: 1309-10. PMID 19057551 DOI: 10.1038/nm1208-1309  1
2008 Holmes GL. What constitutes a relevant animal model of the ketogenic diet? Epilepsia. 49: 57-60. PMID 19049589 DOI: 10.1111/j.1528-1167.2008.01836.x  0.01
2008 Holmes GL. Commentary on "Factors influencing clinical features of absence seizures". Epilepsia. 49: 2141-3. PMID 19049571 DOI: 10.1111/j.1528-1167.2008.01818.x  0.01
2008 Faught E, Holmes GL, Rosenfeld WE, Novak G, Neto W, Greenspan A, Schmitt J, Yuen E, Reines S, Haas M. Randomized, controlled, dose-ranging trial of carisbamate for partial-onset seizures. Neurology. 71: 1586-93. PMID 19001248 DOI: 10.1212/01.wnl.0000334751.89859.7f  1
2008 Holmes GL, Frank LM, Sheth RD, Philbrook B, Wooten JD, Vuong A, Kerls S, Hammer AE, Messenheimer J. Lamotrigine monotherapy for newly diagnosed typical absence seizures in children. Epilepsy Research. 82: 124-32. PMID 18778916 DOI: 10.1016/j.eplepsyres.2008.07.016  1
2008 Meador KJ, Pennell PB, Harden CL, Gordon JC, Tomson T, Kaplan PW, Holmes GL, French JA, Hauser WA, Wells PG, Cramer JA. Pregnancy registries in epilepsy: a consensus statement on health outcomes. Neurology. 71: 1109-17. PMID 18703463 DOI: 10.1212/  1
2008 Holmes GL. Commentary on Hewapathirane et al. (in vivo imaging of seizure activity in a novel developmental seizure model) seizure-induced brain damage: from tadpoles to children. Experimental Neurology. 213: 7-9. PMID 18639873 DOI: 10.1016/j.expneurol.2008.05.005  0.01
2008 Holmes GL, Dichter MA. Prolonged febrile seizures: underrecognized and perhaps underappreciated? Neurology. 71: 162-3. PMID 18625962 DOI: 10.1212/01.wnl.0000317097.62490.c8  1
2008 Tyzio R, Minlebaev M, Rheims S, Ivanov A, Jorquera I, Holmes GL, Zilberter Y, Ben-Ari Y, Khazipov R. Postnatal changes in somatic gamma-aminobutyric acid signalling in the rat hippocampus. The European Journal of Neuroscience. 27: 2515-28. PMID 18547241 DOI: 10.1111/j.1460-9568.2008.06234.x  1
2008 Rheims S, Minlebaev M, Ivanov A, Represa A, Khazipov R, Holmes GL, Ben-Ari Y, Zilberter Y. Excitatory GABA in rodent developing neocortex in vitro. Journal of Neurophysiology. 100: 609-19. PMID 18497364 DOI: 10.1152/jn.90402.2008  1
2008 Mikati M, Holmes GL. Guideline and algorithms for treatment of pediatric epilepsy in the West: how about the individual patient and the rest of the world? Epileptic Disorders : International Epilepsy Journal With Videotape. 10: 69-71. PMID 18494087  0.32
2008 Zhao Q, Raghavendra M, Holmes GL. Effect of TTX suppression of hippocampal activity following status epilepticus. Seizure. 17: 637-45. PMID 18486497 DOI: 10.1016/j.seizure.2008.04.004  0.68
2008 Lenck-Santini PP, Holmes GL. Altered phase precession and compression of temporal sequences by place cells in epileptic rats. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5053-62. PMID 18463258 DOI: 10.1523/JNEUROSCI.5024-07.2008  1
2008 Ben-Ari Y, Holmes GL. [Relevance of basic research to clinical data: Good answers, wrong questions!]. Neuro-Chirurgie. 54: 123-7. PMID 18417172 DOI: 10.1016/j.neuchi.2008.02.001  1
2008 Zhao Q, Shatskikh T, Marolewski A, Rusche JR, Holmes GL. Effects of uridine on kindling. Epilepsy & Behavior : E&B. 13: 47-51. PMID 18321784 DOI: 10.1016/j.yebeh.2008.02.002  0.68
2008 Holmes GL, Zhao Q. Choosing the correct antiepileptic drugs: from animal studies to the clinic. Pediatric Neurology. 38: 151-62. PMID 18279749 DOI: 10.1016/j.pediatrneurol.2007.09.008  0.68
2008 Ben-Ari Y, Holmes GL. Relevance of basic research to clinical data: good answers, wrong questions! Epilepsy Currents / American Epilepsy Society. 8: 19-22. PMID 18265884 DOI: 10.1111/j.1535-7511.2007.00222.x  1
2007 Holmes GL. Influence of brain development on status epilepticus. Epilepsia. 48: 19-20. PMID 18329989  0.01
2007 Isaev D, Isaeva E, Shatskih T, Zhao Q, Smits NC, Shworak NW, Khazipov R, Holmes GL. Role of extracellular sialic acid in regulation of neuronal and network excitability in the rat hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11587-94. PMID 17959801 DOI: 10.1523/JNEUROSCI.2033-07.2007  1
2007 Tyzio R, Holmes GL, Ben-Ari Y, Khazipov R. Timing of the developmental switch in GABA(A) mediated signaling from excitation to inhibition in CA3 rat hippocampus using gramicidin perforated patch and extracellular recordings. Epilepsia. 48: 96-105. PMID 17910587 DOI: 10.1111/j.1528-1167.2007.01295.x  1
2007 Stafstrom CE, Holmes GL. Can preventative antiepileptic therapy alter outcome in infants with tuberous sclerosis complex? Epilepsia. 48: 1632-4. PMID 17692053 DOI: 10.1111/j.1528-1167.2007.01178_4.x  1
2007 Zhou JL, Shatskikh TN, Liu X, Holmes GL. Impaired single cell firing and long-term potentiation parallels memory impairment following recurrent seizures. The European Journal of Neuroscience. 25: 3667-77. PMID 17610586 DOI: 10.1111/j.1460-9568.2007.05598.x  0.44
2007 Holmes GL, Ben-Ari Y. A single episode of neonatal seizures permanently alters glutamatergic synapses. Annals of Neurology. 61: 379-81. PMID 17469115 DOI: 10.1002/ana.21136  1
2007 Zhou JL, Lenck-Santini PP, Holmes GL. Postictal single-cell firing patterns in the hippocampus. Epilepsia. 48: 713-9. PMID 17437414 DOI: 10.1111/j.1528-1167.2006.00942.x  1
2007 Holmes GL, Stafstrom CE. Tuberous sclerosis complex and epilepsy: recent developments and future challenges. Epilepsia. 48: 617-30. PMID 17386056 DOI: 10.1111/j.1528-1167.2007.01035.x  1
2007 Isaev D, Isaeva E, Khazipov R, Holmes GL. Shunting and hyperpolarizing GABAergic inhibition in the high-potassium model of ictogenesis in the developing rat hippocampus. Hippocampus. 17: 210-9. PMID 17294460 DOI: 10.1002/hipo.20259  1
2007 Zhou JL, Lenck-Santini PP, Zhao Q, Holmes GL. Effect of interictal spikes on single-cell firing patterns in the hippocampus. Epilepsia. 48: 720-31. PMID 17284294 DOI: 10.1111/j.1528-1167.2006.00972.x  1
2007 Zhou JL, Zhao Q, Holmes GL. Effect of levetiracetam on visual-spatial memory following status epilepticus. Epilepsy Research. 73: 65-74. PMID 17029741 DOI: 10.1016/j.eplepsyres.2006.08.007  0.68
2006 Ben-Ari Y, Holmes GL. Effects of seizures on developmental processes in the immature brain. The Lancet. Neurology. 5: 1055-63. PMID 17110286 DOI: 10.1016/S1474-4422(06)70626-3  1
2006 Shatskikh TN, Raghavendra M, Zhao Q, Cui Z, Holmes GL. Electrical induction of spikes in the hippocampus impairs recognition capacity and spatial memory in rats. Epilepsy & Behavior : E&B. 9: 549-56. PMID 17027341 DOI: 10.1016/j.yebeh.2006.08.014  0.68
2006 Zhao Q, Boismenu R, Rusche JR, Holmes GL. Lack of effect of secretin on kindling and seizures. Epilepsy & Behavior : E&B. 9: 46-50. PMID 16723277 DOI: 10.1016/j.yebeh.2006.04.006  0.68
2006 Zhao Q, Marolewski A, Rusche JR, Holmes GL. Effects of uridine in models of epileptogenesis and seizures. Epilepsy Research. 70: 73-82. PMID 16621451 DOI: 10.1016/j.eplepsyres.2006.03.003  0.68
2006 Isaeva E, Isaev D, Khazipov R, Holmes GL. Selective impairment of GABAergic synaptic transmission in the flurothyl model of neonatal seizures. The European Journal of Neuroscience. 23: 1559-66. PMID 16553619 DOI: 10.1111/j.1460-9568.2006.04693.x  1
2006 Holmes GL, Lenck-Santini PP. Role of interictal epileptiform abnormalities in cognitive impairment. Epilepsy & Behavior : E&B. 8: 504-15. PMID 16540376 DOI: 10.1016/j.yebeh.2005.11.014  1
2006 Holmes GL. Clinical evidence that epilepsy is a progressive disorder with special emphasis on epilepsy syndromes that do progress. Advances in Neurology. 97: 323-31. PMID 16383141  1
2005 Neill JC, Liu Z, Mikati M, Holmes GL. Pilocarpine seizures cause age-dependent impairment in auditory location discrimination. Journal of the Experimental Analysis of Behavior. 84: 357-70. PMID 16596970 DOI: 10.1901/JEAB.2005.84-04  0.52
2005 Isaev D, Isaeva E, Khazipov R, Holmes GL. Anticonvulsant action of GABA in the high potassium-low magnesium model of ictogenesis in the neonatal rat hippocampus in vivo and in vitro. Journal of Neurophysiology. 94: 2987-92. PMID 16000527 DOI: 10.1152/jn.00138.2005  1
2005 Zhao Q, Hu Y, Holmes GL. Effect of topiramate on cognitive function and activity level following neonatal seizures. Epilepsy & Behavior : E&B. 6: 529-36. PMID 15878305 DOI: 10.1016/j.yebeh.2005.03.001  0.68
2005 Ben-Ari Y, Holmes GL. The multiple facets of gamma-aminobutyric acid dysfunction in epilepsy. Current Opinion in Neurology. 18: 141-5. PMID 15791144  1
2004 Holmes GL. Models for generalized seizures. Supplements to Clinical Neurophysiology. 57: 415-24. PMID 16106641  0.01
2004 Khazipov R, Sirota A, Leinekugel X, Holmes GL, Ben-Ari Y, Buzsáki G. Early motor activity drives spindle bursts in the developing somatosensory cortex. Nature. 432: 758-61. PMID 15592414 DOI: 10.1038/nature03132  1
2004 Hoffmann AF, Zhao Q, Holmes GL. Cognitive impairment following status epilepticus and recurrent seizures during early development: support for the "two-hit hypothesis". Epilepsy & Behavior : E&B. 5: 873-7. PMID 15582835 DOI: 10.1016/j.yebeh.2004.09.005  0.68
2004 Takeoka M, Riviello JJ, Duffy FH, Kim F, Kennedy DN, Makris N, Caviness VS, Holmes GL. Bilateral volume reduction of the superior temporal areas in Landau-Kleffner syndrome. Neurology. 63: 1289-92. PMID 15477555  1
2004 Holmes GL. Effects of early seizures on later behavior and epileptogenicity. Mental Retardation and Developmental Disabilities Research Reviews. 10: 101-5. PMID 15362164 DOI: 10.1002/mrdd.20019  0.01
2004 Akman C, Zhao Q, Liu X, Holmes GL. Effect of food deprivation during early development on cognition and neurogenesis in the rat. Epilepsy & Behavior : E&B. 5: 446-54. PMID 15256180 DOI: 10.1016/j.yebeh.2004.03.008  0.68
2004 Mikati MA, Holmes GL, Werner S, Bakkar N, Carmant L, Liu Z, Stafstrom CE. Effects of nimodipine on the behavioral sequalae of experimental status epilepticus in prepubescent rats. Epilepsy & Behavior : E&B. 5: 168-74. PMID 15123017 DOI: 10.1016/j.yebeh.2003.12.002  1
2004 Khazipov R, Khalilov I, Tyzio R, Morozova E, Ben-Ari Y, Holmes GL. Developmental changes in GABAergic actions and seizure susceptibility in the rat hippocampus. The European Journal of Neuroscience. 19: 590-600. PMID 14984409 DOI: 10.1111/j.0953-816X.2003.03152.x  1
2004 Zhao Q, Stafstrom CE, Fu DD, Hu Y, Holmes GL. Detrimental effects of the ketogenic diet on cognitive function in rats. Pediatric Research. 55: 498-506. PMID 14711901 DOI: 10.1203/01.PDR.0000112032.47575.D1  1
2003 Liu X, Muller RU, Huang LT, Kubie JL, Rotenberg A, Rivard B, Cilio MR, Holmes GL. Seizure-induced changes in place cell physiology: relationship to spatial memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11505-15. PMID 14684854  1
2003 Khalilov I, Holmes GL, Ben-Ari Y. In vitro formation of a secondary epileptogenic mirror focus by interhippocampal propagation of seizures. Nature Neuroscience. 6: 1079-85. PMID 14502289 DOI: 10.1038/nn1125  1
2003 Boukhezra O, Riviello P, Fu DD, Lui X, Zhao Q, Akman C, Holmes GL. Effect of the postictal state on visual-spatial memory in immature rats. Epilepsy Research. 55: 165-75. PMID 12972171  0.68
2003 Akman CI, Hu Y, Fu DD, Holmes GL. The influence of cognitive reserve on seizure-induced injury. Epilepsy & Behavior : E&B. 4: 435-40. PMID 12899866  0.36
2003 Holmes GL, Ben-Ari Y. Seizing hold of seizures. Nature Medicine. 9: 994-6. PMID 12894158 DOI: 10.1038/nm0803-994  1
2003 Goodkin HP, Liu X, Holmes GL. Diazepam terminates brief but not prolonged seizures in young, naïve rats. Epilepsia. 44: 1109-12. PMID 12887445 DOI: 10.1046/j.1528-1157.2003.62402.x  1
2003 Tyzio R, Ivanov A, Bernard C, Holmes GL, Ben-Ari Y, Khazipov R. Membrane potential of CA3 hippocampal pyramidal cells during postnatal development. Journal of Neurophysiology. 90: 2964-72. PMID 12867526 DOI: 10.1152/jn.00172.2003  1
2003 Khazipov R, Holmes GL. Synchronization of kainate-induced epileptic activity via GABAergic inhibition in the superfused rat hippocampus in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5337-41. PMID 12832559  1
2003 Takeoka M, Kim F, Caviness VS, Kennedy DN, Makris N, Holmes GL. MRI volumetric analysis in rasmussen encephalitis: a longitudinal study. Epilepsia. 44: 247-51. PMID 12558582 DOI: 10.1046/j.1528-1157.2003.16202.x  1
2002 Drage MG, Holmes GL, Seyfried TN. Hippocampal neurons and glia in epileptic EL mice. Journal of Neurocytology. 31: 681-92. PMID 14501207 DOI: 10.1023/A:1025747813463  1
2002 Kohane DS, Holmes GL, Chau Y, Zurakowski D, Langer R, Cha BH. Effectiveness of muscimol-containing microparticles against pilocarpine-induced focal seizures. Epilepsia. 43: 1462-8. PMID 12460246 DOI: 10.1046/j.1528-1157.2002.11202.x  1
2002 Friedman MN, Geula C, Holmes GL, Herzog AG. GnRH-immunoreactive fiber changes with unilateral amygdala-kindled seizures. Epilepsy Research. 52: 73-7. PMID 12458023 DOI: 10.1016/S0920-1211(02)00196-1  1
2002 Holmes GL. Overtreatment in children with epilepsy. Epilepsy Research. 52: 35-42. PMID 12445958  0.01
2002 Holmes GL. Seizure-induced neuronal injury: animal data. Neurology. 59: S3-6. PMID 12428025  0.01
2002 Faverjon S, Silveira DC, Fu DD, Cha BH, Akman C, Hu Y, Holmes GL. Beneficial effects of enriched environment following status epilepticus in immature rats. Neurology. 59: 1356-64. PMID 12427884  0.36
2002 Cha BH, Silveira DC, Liu X, Hu Y, Holmes GL. Effect of topiramate following recurrent and prolonged seizures during early development. Epilepsy Research. 51: 217-32. PMID 12399072  0.36
2002 Holmes GL, Khazipov R, Ben-Ari Y. Seizure-induced damage in the developing human: relevance of experimental models. Progress in Brain Research. 135: 321-34. PMID 12143352 DOI: 10.1016/S0079-6123(02)35030-1  1
2002 Tandon P, Yang Y, Stafstrom CE, Holmes GL. Downregulation of kainate receptors in the hippocampus following repeated seizures in immature rats. Brain Research. Developmental Brain Research. 136: 145-50. PMID 12101031 DOI: 10.1016/S0165-3806(02)00358-9  1
2002 Stafstrom CE, Holmes GL. Infantile spasms: criteria for an animal model. International Review of Neurobiology. 49: 391-411. PMID 12040904  1
2002 Stafstrom CE, Holmes GL. Effects of uncontrolled seizures. Neural changes in animal models. Advances in Experimental Medicine and Biology. 497: 171-94. PMID 11993731  1
2002 Mikati MA, Lepejian GA, Holmes GL. Medical treatment of patients with infantile spasms. Clinical Neuropharmacology. 25: 61-70. PMID 11981230  0.56
2002 Holmes GL, Khazipov R, Ben-Ari Y. New concepts in neonatal seizures. Neuroreport. 13: A3-8. PMID 11924904  1
2002 Miura K, Kishino T, Li E, Webber H, Dikkes P, Holmes GL, Wagstaff J. Neurobehavioral and electroencephalographic abnormalities in Ube3a maternal-deficient mice. Neurobiology of Disease. 9: 149-59. PMID 11895368 DOI: 10.1006/nbdi.2001.0463  1
2002 Holmes GL, Yang Y, Liu Z, Cermak JM, Sarkisian MR, Stafstrom CE, Neill JC, Blusztajn JK. Seizure-induced memory impairment is reduced by choline supplementation before or after status epilepticus. Epilepsy Research. 48: 3-13. PMID 11823105 DOI: 10.1016/S0920-1211(01)00321-7  1
2001 Pearl PL, Carrazana EJ, Holmes GL. The Landau-Kleffner Syndrome. Epilepsy Currents / American Epilepsy Society. 1: 39-45. PMID 15309183 DOI: 10.1046/j.1535-7597.2001.00012.x  0.4
2001 Sogawa Y, Monokoshi M, Silveira DC, Cha BH, Cilio MR, McCabe BK, Liu X, Hu Y, Holmes GL. Timing of cognitive deficits following neonatal seizures: relationship to histological changes in the hippocampus. Brain Research. Developmental Brain Research. 131: 73-83. PMID 11718838  0.36
2001 Neill JC, Sarkisian MR, Wang Y, Liu Z, Yu L, Tandon P, Zhang G, Holmes GL, Geller AI. Enhanced auditory reversal learning by genetic activation of protein kinase C in small groups of rat hippocampal neurons. Brain Research. Molecular Brain Research. 93: 127-36. PMID 11589990 DOI: 10.1016/S0165-3806(01)00204-8  1
2001 Takeoka M, Holmes GL, Thiele E, Bourgeois BF, Helmers SL, Duffy FH, Riviello JJ. Topiramate and metabolic acidosis in pediatric epilepsy. Epilepsia. 42: 387-92. PMID 11442157 DOI: 10.1046/j.1528-1157.2001.04500.x  1
2001 Holmes GL. Pathogenesis of learning disabilities in epilepsy. Epilepsia. 42: 13-5; discussion 19-. PMID 11422346  0.01
2001 Holmes GL, Ben-Ari Y. The neurobiology and consequences of epilepsy in the developing brain. Pediatric Research. 49: 320-5. PMID 11228256 DOI: 10.1203/00006450-200103000-00004  1
2001 Cilio MR, Bolanos AR, Liu Z, Schmid R, Yang Y, Stafstrom CE, Mikati MA, Holmes GL. Anticonvulsant action and long-term effects of gabapentin in the immature brain. Neuropharmacology. 40: 139-47. PMID 11077080 DOI: 10.1016/S0028-3908(00)00103-9  1
2000 Su SW, Cilio MR, Sogawa Y, Silveira DC, Holmes GL, Stafstrom CE, Silveira D. Timing of ketogenic diet initiation in an experimental epilepsy model. Brain Research. Developmental Brain Research. 125: 131-8. PMID 11154768 DOI: 10.1016/S0165-3806(01)00157-2  1
2000 Holmes GL, Chevassus au Louis N. Cortical dysplasia: developmental effects. Advances in Neurology. 84: 497-509. PMID 11091891  0.52
2000 Yang Y, Liu Z, Cermak JM, Tandon P, Sarkisian MR, Stafstrom CE, Neill JC, Blusztajn JK, Holmes GL. Protective effects of prenatal choline supplementation on seizure-induced memory impairment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: RC109. PMID 11069978  1
2000 Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL. Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. Brain Research. 878: 223-7. PMID 10996157 DOI: 10.1016/S0006-8993(00)02703-7  1
2000 Holmes GL. Clinical spectrum of benign focal epilepsies of childhood. Epilepsia. 41: 1051-2. PMID 10961637  1
2000 Morrell MJ, McLean MJ, Willmore LJ, Privitera MD, Faught RE, Holmes GL, Magnus L, Bernstein P, Rose-Legatt. Efficacy of gabapentin as adjunctive therapy in a large, multicenter study. The Steps Study Group. Seizure. 9: 241-8. PMID 10880282 DOI: 10.1053/seiz.2000.0407  1
2000 Villeneuve N, Ben-Ari Y, Holmes GL, Gaiarsa JL. Neonatal seizures induced persistent changes in intrinsic properties of CA1 rat hippocampal cells. Annals of Neurology. 47: 729-38. PMID 10852538 DOI: 10.1002/1531-8249(200006)47:6<729::AID-ANA5>3.0.CO;2-C  1
2000 Silveira DC, Schachter SC, Schomer DL, Holmes GL. Flurothyl-induced seizures in rats activate Fos in brainstem catecholaminergic neurons. Epilepsy Research. 39: 1-12. PMID 10690748 DOI: 10.1016/S0920-1211(99)00106-0  1
2000 Silveira DC, Klein P, Ransil BJ, Liu Z, Hori A, Holmes GL, de LaCalle S, Elmquist J, Herzog AG. Lateral asymmetry in activation of hypothalamic neurons with unilateral amygdaloid seizures. Epilepsia. 41: 34-41. PMID 10643921  1
1999 Huang L, Cilio MR, Silveira DC, McCabe BK, Sogawa Y, Stafstrom CE, Holmes GL. Long-term effects of neonatal seizures: a behavioral, electrophysiological, and histological study. Brain Research. Developmental Brain Research. 118: 99-107. PMID 10611508 DOI: 10.1016/S0165-3806(99)00135-2  1
1999 Schmid R, Tandon P, Stafstrom CE, Holmes GL. Effects of neonatal seizures on subsequent seizure-induced brain injury. Neurology. 53: 1754-61. PMID 10563624  1
1999 Liu Z, Yang Y, Silveira DC, Sarkisian MR, Tandon P, Huang LT, Stafstrom CE, Holmes GL. Consequences of recurrent seizures during early brain development. Neuroscience. 92: 1443-54. PMID 10426498 DOI: 10.1016/S0306-4522(99)00064-0  1
1999 Sarkisian MR, Holmes GL, Carmant L, Liu Z, Yang Y, Stafstrom CE. Effects of hyperthermia and continuous hippocampal stimulation on the immature and adult brain. Brain & Development. 21: 318-25. PMID 10413019 DOI: 10.1016/S0387-7604(99)00032-7  1
1999 McLean MJ, Morrell MJ, Willmore LJ, Privitera MD, Faught RE, Holmes GL, Magnus-Miller L, Bernstein P, Rose-Legatt A. Safety and tolerability of gabapentin as adjunctive therapy in a large, multicenter study. Epilepsia. 40: 965-72. PMID 10403221 DOI: 10.1111/j.1528-1157.1999.tb00804.x  1
1999 Holmes GL, Sarkisian M, Ben-Ari Y, Liu Z, Chevassus-Au-Louis N. Consequences of cortical dysplasia during development in rats. Epilepsia. 40: 537-44. PMID 10386521  1
1999 Muller-Schwarze AB, Tandon P, Liu Z, Yang Y, Holmes GL, Stafstrom CE. Ketogenic diet reduces spontaneous seizures and mossy fiber sprouting in the kainic acid model. Neuroreport. 10: 1517-22. PMID 10380973  1
1999 Tandon P, Yang Y, Das K, Holmes GL, Stafstrom CE. Neuroprotective effects of brain-derived neurotrophic factor in seizures during development. Neuroscience. 91: 293-303. PMID 10336079 DOI: 10.1016/S0306-4522(98)00609-5  1
1999 Mikati MA, Werner S, Gatt A, Liu Z, Rahmeh AA, Rachid RA, Stafstrom CE, Holmes GL. Consequences of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor blockade during status epilepticus in the developing brain. Brain Research. Developmental Brain Research. 113: 139-42. PMID 10064883 DOI: 10.1016/S0165-3806(98)00193-X  1
1999 Gleeson JG, Minnerath SR, Fox JW, Allen KM, Luo RF, Hong SE, Berg MJ, Kuzniecky R, Reitnauer PJ, Borgatti R, Mira AP, Guerrini R, Holmes GL, Rooney CM, Berkovic S, et al. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome. Annals of Neurology. 45: 146-53. PMID 9989615 DOI: 10.1002/1531-8249(199902)45:2<146::AID-ANA3>3.0.CO;2-N  1
1999 Holmes GL, Sarkisian M, Ben-Ari Y, Chevassus-Au-Louis N. Mossy fiber sprouting after recurrent seizures during early development in rats. The Journal of Comparative Neurology. 404: 537-53. PMID 9987996 DOI: 10.1002/(SICI)1096-9861(19990222)404:4<537::AID-CNE9>3.0.CO;2-#  1
1998 Holmes GL, Ben-Ari Y. Seizures in the developing brain: perhaps not so benign after all. Neuron. 21: 1231-4. PMID 9883716 DOI: 10.1016/S0896-6273(00)80642-X  1
1998 Silveira DC, Liu Z, de LaCalle S, Lu J, Klein P, Holmes GL, Herzog AG. Activation of the locus coeruleus after amygdaloid kindling. Epilepsia. 39: 1261-4. PMID 9860060 DOI: 10.1111/j.1528-1157.1998.tb01323.x  1
1998 Holmes GL, Gairsa JL, Chevassus-Au-Louis N, Ben-Ari Y. Consequences of neonatal seizures in the rat: morphological and behavioral effects. Annals of Neurology. 44: 845-57. PMID 9851428 DOI: 10.1002/ana.410440602  1
1998 Vining EP, Freeman JM, Ballaban-Gil K, Camfield CS, Camfield PR, Holmes GL, Shinnar S, Shuman R, Trevathan E, Wheless JW. A multicenter study of the efficacy of the ketogenic diet. Archives of Neurology. 55: 1433-7. PMID 9823827  1
1998 Bolanos AR, Sarkisian M, Yang Y, Hori A, Helmers SL, Mikati M, Tandon P, Stafstrom CE, Holmes GL. Comparison of valproate and phenobarbital treatment after status epilepticus in rats. Neurology. 51: 41-8. PMID 9674776  1
1998 Silveira DC, Liu Z, Holmes GL, Schomer DL, Schachter SC. Seizures in rats treated with kainic acid induce Fos-like immunoreactivity in locus coeruleus. Neuroreport. 9: 1353-7. PMID 9631428  1
1998 Yang Y, Tandon P, Liu Z, Sarkisian MR, Stafstrom CE, Holmes GL. Synaptic reorganization following kainic acid-induced seizures during development. Brain Research. Developmental Brain Research. 107: 169-77. PMID 9593878 DOI: 10.1016/S0165-3806(97)00211-3  1
1998 Rappaport LA, Wypij D, Bellinger DC, Helmers SL, Holmes GL, Barnes PD, Wernovsky G, Kuban KC, Jonas RA, Newburger JW. Relation of seizures after cardiac surgery in early infancy to neurodevelopmental outcome. Boston Circulatory Arrest Study Group. Circulation. 97: 773-9. PMID 9498541  0.32
1997 Sarkisian MR, Tandon P, Liu Z, Yang Y, Hori A, Holmes GL, Stafstrom CE. Multiple kainic acid seizures in the immature and adult brain: ictal manifestations and long-term effects on learning and memory. Epilepsia. 38: 1157-66. PMID 9579915 DOI: 10.1111/j.1528-1157.1997.tb01211.x  1
1997 Hori A, Tandon P, Holmes GL, Stafstrom CE. Ketogenic diet: effects on expression of kindled seizures and behavior in adult rats. Epilepsia. 38: 750-8. PMID 9579901 DOI: 10.1111/j.1528-1157.1997.tb01461.x  1
1997 Mikati MA, Holmes GL. Lamotrigine in absence and primary generalized epilepsies. Journal of Child Neurology. 12: S29-37. PMID 9429128  0.56
1997 Holmes GL. When the first drug does not work: treatment options. The Journal of Pediatrics. 131: 794-6. PMID 9427878  0.01
1997 Liu Z, Holmes GL. Basic fibroblast growth factor-induced seizures in rats. Neuroscience Letters. 233: 85-8. PMID 9350838  0.52
1997 Holmes GL. Gabapentin for treatment of epilepsy in children. Seminars in Pediatric Neurology. 4: 244-50. PMID 9323792 DOI: 10.1016/S1071-9091(97)80041-1  1
1997 Liu Z, Stafstrom CE, Sarkisian MR, Yang Y, Hori A, Tandon P, Holmes GL. Seizure-induced glutamate release in mature and immature animals: an in vivo microdialysis study. Neuroreport. 8: 2019-23. PMID 9223095  1
1997 Holmes GL, Chevassus-Au-Lois N, Sarkisian MR, Ben-Ari Y. [Consequences of recurrent seizures during development]. Revista De Neurologia. 25: 749-53. PMID 9206603  1
1997 Stafstrom CE, Tandon P, Hori A, Liu Z, Mikati MA, Holmes GL. Acute effects of MK801 on kainic acid-induced seizures in neonatal rats. Epilepsy Research. 26: 335-44. PMID 9095395 DOI: 10.1016/S0920-1211(96)00904-7  1
1997 Kramer U, Riviello JJ, Carmant L, Black PM, Madsen J, Holmes GL. Clinical characteristics of complex partial seizures: a temporal versus a frontal lobe onset. Seizure. 6: 57-61. PMID 9061825 DOI: 10.1016/S1059-1311(97)80054-4  1
1997 Helmers SL, Wypij D, Constantinou JE, Newburger JW, Hickey PR, Carrazana EJ, Barlow JK, Kuban KC, Holmes GL. Perioperative electroencephalographic seizures in infants undergoing repair of complex congenital cardiac defects. Electroencephalography and Clinical Neurophysiology. 102: 27-36. PMID 9060852  0.4
1997 Liu Z, Holmes GL. Basic fibroblast growth factor is highly neuroprotective against seizure-induced long-term behavioural deficits. Neuroscience. 76: 1129-38. PMID 9027873  0.52
1996 Liu Z, Stafstrom CE, Sarkisian M, Tandon P, Yang Y, Hori A, Holmes GL. Age-dependent effects of glutamate toxicity in the hippocampus. Brain Research. Developmental Brain Research. 97: 178-84. PMID 8997502 DOI: 10.1016/S0165-3806(96)00141-1  1
1996 Neill JC, Liu Z, Sarkisian M, Tandon P, Yang Y, Stafstrom CE, Holmes GL. Recurrent seizures in immature rats: effect on auditory and visual discrimination. Brain Research. Developmental Brain Research. 95: 283-92. PMID 8874904 DOI: 10.1016/S0165-3806(96)00099-5  1
1996 Tandon P, Liu Z, Stafstrom CE, Sarkisian M, Werner SJ, Mikati M, Yang Y, Holmes GL. Long-term effects of excitatory amino acid antagonists NBQX and MK-801 on the developing brain. Brain Research. Developmental Brain Research. 95: 256-62. PMID 8874901 DOI: 10.1016/S0165-3806(96)00094-6  1
1996 Carmant L, Carrazana E, Kramer U, Helmers SL, Holmes GL, Black PM, Mikati MA. Pharyngeal dysesthesia as an aura in temporal lobe epilepsy. Epilepsia. 37: 911-3. PMID 8814105  1
1996 Carmant L, Kramer U, Holmes GL, Mikati MA, Riviello JJ, Helmers SL. Differential diagnosis of staring spells in children: a video-EEG study. Pediatric Neurology. 14: 199-202. PMID 8736402 DOI: 10.1016/0887-8994(96)00080-X  1
1996 Holmes GL. Intractable epilepsy in children. Epilepsia. 37: 14-27. PMID 8681906 DOI: 10.1111/j.1528-1157.1996.tb01815.x  1
1995 Lynch BJ, O'Tuama LA, Treves ST, Mikati M, Holmes GL. Correlation of 99mTc-HMPAO SPECT with EEG monitoring: prognostic value for outcome of epilepsy surgery in children. Brain & Development. 17: 409-417. PMID 8747419 DOI: 10.1016/0387-7604(95)00066-6  0.32
1995 Carmant L, Liu Z, Werner SJ, Mikati MA, Holmes GL. Effect of kainic acid-induced status epilepticus on inositol-trisphosphate and seizure-induced brain damage in mature and immature animals. Brain Research. Developmental Brain Research. 89: 67-72. PMID 8575094 DOI: 10.1016/0165-3806(95)00110-Y  1
1995 Liu Z, Mikati M, Holmes GL. Mesial temporal sclerosis: pathogenesis and significance. Pediatric Neurology. 12: 5-16. PMID 7748361  0.52
1995 Kramer U, Carmant L, Riviello JJ, Stauffer A, Helmers SL, Mikati MA, Holmes GL. Psychogenic seizures: video telemetry observations in 27 patients. Pediatric Neurology. 12: 39-41. PMID 7748358 DOI: 10.1016/0887-8994(94)00115-I  1
1995 Carmant L, Kramer U, Mikati MA, Riviello JJ, Helmers SL, Holmes GL. Pseudoseizure manifestations in two preschool age children. Seizure. 4: 147-9. PMID 7670767 DOI: 10.1016/S1059-1311(95)80096-4  1
1995 Madsen JR, Carmant L, Holmes GL, Black PM. Corpus callosotomy in children. Neurosurgery Clinics of North America. 6: 541-8. PMID 7670327  1
1995 Riviello JJ, Helmers SL, Mikati M, Holmes GL. The preoperative evaluation of the child with epilepsy. Neurosurgery Clinics of North America. 6: 431-42. PMID 7670317  0.32
1995 Adelson PD, Black PM, Madsen JR, Kramer U, Rockoff MA, Riviello JJ, Helmers SL, Mikati M, Holmes GL. Use of subdural grids and strip electrodes to identify a seizure focus in children. Pediatric Neurosurgery. 22: 174-80. PMID 7619717 DOI: 10.1159/000120898  1
1995 Carmant L, Kramer U, Riviello JJ, Helmers SL, Mikati MA, Madsen JR, Black PM, Lombroso CT, Holmes GL. EEG prior to hemispherectomy: correlation with outcome and pathology. Electroencephalography and Clinical Neurophysiology. 94: 265-70. PMID 7537198 DOI: 10.1016/0013-4694(95)98477-P  1
1995 Holmes GL. [Neonatal seizures]. Revista De Neurologia. 23: S280-4. PMID 7497300  0.01
1994 Holmes GL. Stopping antiepileptic drugs in children: when and why. Annals of Neurology. 35: 509-10. PMID 8179295 DOI: 10.1002/ana.410350502  0.01
1994 Thurber SJ, Mikati MA, Stafstrom CE, Jensen FE, Holmes GL. Quisqualic acid-induced seizures during development: a behavioral and EEG study. Epilepsia. 35: 868-75. PMID 8082636  1
1994 Mikati MA, Holmes GL, Chronopoulos A, Hyde P, Thurber S, Gatt A, Liu Z, Werner S, Stafstrom CE. Phenobarbital modifies seizure-related brain injury in the developing brain. Annals of Neurology. 36: 425-33. PMID 8080250 DOI: 10.1002/ana.410360314  1
1994 Carmant L, Holmes GL, Sawyer S, Rifai N, Anderson J, Mikati MA. Efficacy of felbamate in therapy for partial epilepsy in children. The Journal of Pediatrics. 125: 481-6. PMID 8071763 DOI: 10.1016/S0022-3476(05)83302-5  1
1994 Freeman JM, Holmes GL. Should uncomplicated seizures be treated? Point--counterpoint. Current Problems in Pediatrics. 24: 139-48. PMID 8039410 DOI: 10.1016/0045-9380(94)90046-9  1
1994 Carmant L, Holmes GL. Commissurotomies in children. Journal of Child Neurology. 9: 50-60. PMID 7806786  1
1994 Liu Z, Gatt A, Werner SJ, Mikati MA, Holmes GL. Long-term behavioral deficits following pilocarpine seizures in immature rats. Epilepsy Research. 19: 191-204. PMID 7698095  0.56
1993 Holmes GL, Chronopoulos A, Stafstrom CE, Mikati MA, Thurber SJ, Hyde PA, Thompson JL. Effects of kindling on subsequent learning, memory, behavior, and seizure susceptibility. Brain Research. Developmental Brain Research. 73: 71-7. PMID 8513557 DOI: 10.1016/0165-3806(93)90047-E  1
1993 Stafstrom CE, Holmes GL. Electrophysiologic studies in the newborn. Seminars in Neurology. 13: 10-9. PMID 8511411 DOI: 10.1055/s-2008-1041102  1
1993 Stafstrom CE, Chronopoulos A, Thurber S, Thompson JL, Holmes GL. Age-dependent cognitive and behavioral deficits after kainic acid seizures. Epilepsia. 34: 420-32. PMID 8504777  1
1993 Holmes GL. Benign focal epilepsies of childhood. Epilepsia. 34: S49-61. PMID 8500433  1
1993 Chronopoulos A, Stafstrom C, Thurber S, Hyde P, Mikati M, Holmes GL. Neuroprotective effect of felbamate after kainic acid-induced status epilepticus. Epilepsia. 34: 359-66. PMID 8453945 DOI: 10.1111/j.1528-1157.1993.tb02422.x  0.56
1993 Stafstrom CE, Holmes GL, Thompson JL. MK801 pretreatment reduces kainic acid-induced spontaneous seizures in prepubescent rats. Epilepsy Research. 14: 41-8. PMID 8449178 DOI: 10.1016/0920-1211(93)90073-G  1
1993 Carrazana EJ, Lombroso CT, Mikati M, Helmers S, Holmes GL. Facilitation of infantile spasms by partial seizures. Epilepsia. 34: 97-109. PMID 8422869  0.4
1993 Newburger JW, Jonas RA, Wernovsky G, Wypij D, Hickey PR, Kuban KC, Farrell DM, Holmes GL, Helmers SL, Constantinou J. A comparison of the perioperative neurologic effects of hypothermic circulatory arrest versus low-flow cardiopulmonary bypass in infant heart surgery. The New England Journal of Medicine. 329: 1057-64. PMID 8371727 DOI: 10.1056/NEJM199310073291501  0.32
1993 Liu Z, Gatt A, Mikati M, Holmes GL. Effect of temperature on kainic acid-induced seizures. Brain Research. 631: 51-8. PMID 8298996  0.52
1993 Liu Z, D'Amore PA, Mikati M, Gatt A, Holmes GL. Neuroprotective effect of chronic infusion of basic fibroblast growth factor on seizure-associated hippocampal damage. Brain Research. 626: 335-8. PMID 8281447  0.52
1993 Holmes GL. Critical issues in the treatment of epilepsy. American Journal of Hospital Pharmacy. 50: S5-16. PMID 8122700  0.01
1993 Holmes GL, Thurber SJ, Liu Z, Stafstrom CE, Gatt A, Mikati MA. Effects of quisqualic acid and glutamate on subsequent learning, emotionality, and seizure susceptibility in the immature and mature animal. Brain Research. 623: 325-8. PMID 8106123 DOI: 10.1016/0006-8993(93)91447-Z  1
1993 Schiffmann R, Mannheim GB, Stafstrom CE, Hamburger SD, Holmes GL. Posterior fossa abnormalities in children with infantile spasms. Journal of Child Neurology. 8: 360-5. PMID 7693798  1
1992 Stafstrom CE, Thompson JL, Holmes GL. Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures. Brain Research. Developmental Brain Research. 65: 227-36. PMID 1572066 DOI: 10.1016/0165-3806(92)90184-X  1
1992 Holmes GL, Thompson JL, Huh K, Stuart JD, Carl GF. Effects of neural transplantation on seizures in the immature genetically epilepsy-prone rat. Experimental Neurology. 116: 52-63. PMID 1559564 DOI: 10.1016/0014-4886(92)90175-P  1
1992 Carrazana EJ, Liu GT, Holmes GL. Crossed cerebellar atrophy in the Dyke-Davidoff-Masson syndrome. Neuroradiology. 34: 326-7. PMID 1528445  0.4
1992 Thurber S, Chronopoulos A, Stafstrom CE, Holmes GL. Behavioral effects of continuous hippocampal stimulation in the developing rat. Brain Research. Developmental Brain Research. 68: 35-40. PMID 1521323 DOI: 10.1016/0165-3806(92)90245-R  1
1992 Jensen FE, Holmes GL, Lombroso CT, Blume HK, Firkusny IR. Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats. Epilepsia. 33: 971-80. PMID 1464280  0.44
1992 Holmes GL. Rolandic epilepsy: clinical and electroencephalographic features. Epilepsy Research. Supplement. 6: 29-43. PMID 1418488  1
1991 Thompson JL, Carl FG, Holmes GL. Effects of age on seizure susceptibility in genetically epilepsy-prone rats (GEPR-9s). Epilepsia. 32: 161-7. PMID 2004620  0.56
1991 Holmes GL. Seizures: introduction and commentary. Pediatric Annals. 20: 13-4. PMID 2000229  1
1991 Holmes GL. The long-term effects of seizures on the developing brain: clinical and laboratory issues. Brain & Development. 13: 393-409. PMID 1810153  1
1991 Holmes GL, Thompson JL, Huh K, Holmes C, Carl GF. Effect of neural transplants on seizure frequency and kindling in immature rats following kainic acid. Brain Research. Developmental Brain Research. 64: 47-56. PMID 1786648 DOI: 10.1016/0165-3806(91)90208-Z  1
1991 Holmes GL. Effect of non-sex hormones on neuronal excitability, seizures, and the electroencephalogram. Epilepsia. 32: S11-8. PMID 1659981  0.01
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