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Ehud Y. Isacoff - Publications

Affiliations: 
Molecular and Cell Biology University of California, Berkeley, Berkeley, CA 
Area:
Channel Physiology
Website:
http://mcb.berkeley.edu/faculty/NEU/isacoffe.html

198 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Newman ZL, Bakshinskaya D, Schultz R, Kenny SJ, Moon S, Aghi K, Stanley C, Marnani N, Li R, Bleier J, Xu K, Isacoff EY. Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging. Nature Communications. 13: 229. PMID 35017509 DOI: 10.1038/s41467-021-27815-2  0.786
2021 Donthamsetti P, Winter N, Hoagland A, Stanley C, Visel M, Lammel S, Trauner D, Isacoff E. Cell specific photoswitchable agonist for reversible control of endogenous dopamine receptors. Nature Communications. 12: 4775. PMID 34362914 DOI: 10.1038/s41467-021-25003-w  0.777
2020 Oldfield CS, Grossrubatscher I, Chávez M, Hoagland A, Huth AR, Carroll EC, Prendergast A, Qu T, Gallant JL, Wyart C, Isacoff EY. Experience, circuit dynamics and forebrain recruitment in larval zebrafish prey capture. Elife. 9. PMID 32985972 DOI: 10.7554/eLife.56619  0.765
2020 Mony L, Stroebel D, Isacoff EY. Dimer interaction in the Hv1 proton channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 32788354 DOI: 10.1073/pnas.2010032117  0.401
2020 Li Z, Zhang Q, Chou SW, Newman Z, Turcotte R, Natan R, Dai Q, Isacoff EY, Ji N. Fast widefield imaging of neuronal structure and function with optical sectioning in vivo. Science Advances. 6: eaaz3870. PMID 32494711 DOI: 10.1126/Sciadv.Aaz3870  0.73
2020 Morstein J, Dacheux MA, Norman DD, Shemet A, Donthamsetti PC, Citir M, Frank J, Schultz C, Isacoff EY, Parrill AL, Tigyi GJ, Trauner D. Optical Control of Lysophosphatidic Acid Signaling. Journal of the American Chemical Society. PMID 32469525 DOI: 10.1021/Jacs.0C02154  0.343
2019 Habrian CH, Levitz J, Vyklicky V, Fu Z, Hoagland A, McCort-Tranchepain I, Acher F, Isacoff EY. Conformational pathway provides unique sensitivity to a synaptic mGluR. Nature Communications. 10: 5572. PMID 31804469 DOI: 10.1038/S41467-019-13407-8  0.799
2019 Donthamsetti PC, Broichhagen J, Vyklicky V, Stanley C, Fu Z, Visel M, Levitz JL, Javitch JA, Trauner D, Isacoff EY. Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor. Journal of the American Chemical Society. PMID 31291105 DOI: 10.1021/Jacs.9B02895  0.707
2019 Berry MH, Holt A, Salari A, Veit J, Visel M, Levitz J, Aghi K, Gaub BM, Sivyer B, Flannery JG, Isacoff EY. Restoration of high-sensitivity and adapting vision with a cone opsin. Nature Communications. 10: 1221. PMID 30874546 DOI: 10.1038/S41467-019-09124-X  0.768
2018 Xiao T, Ackerman CM, Carroll EC, Jia S, Hoagland A, Chan J, Thai B, Liu CS, Isacoff EY, Chang CJ. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nature Chemical Biology. PMID 29867144 DOI: 10.1038/S41589-018-0062-Z  0.766
2018 Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff EY. Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature Communications. 9: 1112. PMID 29535310 DOI: 10.1038/S41467-018-03585-2  0.762
2017 Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Trauner D, Flannery J, Isacoff EY. Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nature Communications. 8: 1862. PMID 29192252 DOI: 10.1038/S41467-017-01990-7  0.782
2017 Donthamsetti P, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff EY, Trauner D. Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. Journal of the American Chemical Society. PMID 29166564 DOI: 10.1021/Jacs.7B07659  0.682
2017 Pantoja C, Hoagland A, Carroll E, Schoppik D, Isacoff EY. Measuring Behavioral Individuality in the Acoustic Startle Behavior in Zebrafish. Bio-Protocol. 7. PMID 28752108 DOI: 10.21769/BioProtoc.2200  0.757
2017 Kienzler MA, Isacoff EY. Precise modulation of neuronal activity with synthetic photoswitchable ligands. Current Opinion in Neurobiology. PMID 28690101 DOI: 10.1016/J.Conb.2017.05.021  0.392
2017 Palty R, Fu Z, Isacoff EY. Sequential Steps of CRAC Channel Activation. Cell Reports. 19: 1929-1939. PMID 28564609 DOI: 10.1016/J.Celrep.2017.05.025  0.378
2017 Berlin S, Isacoff EY. Synapses in the spotlight with synthetic optogenetics. Embo Reports. PMID 28396573 DOI: 10.15252/embr.201744010  0.406
2017 Levitz J, Broichhagen J, Leippe P, Konrad D, Trauner D, Isacoff EY. Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396447 DOI: 10.1073/Pnas.1619652114  0.701
2017 Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff EY, Pardo LA. A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore. The Journal of General Physiology. PMID 28360219 DOI: 10.1085/Jgp.201611742  0.39
2017 Newman ZL, Hoagland A, Aghi K, Worden K, Levy SL, Son JH, Lee LP, Isacoff EY. Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction. Neuron. PMID 28285823 DOI: 10.1016/J.Neuron.2017.02.028  0.771
2016 Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff EY, Baier H, Trauner D. Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chemical Science. 7: 2347-2352. PMID 28090283 DOI: 10.1039/C5Sc04084A  0.734
2016 Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff EY. Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors. Neuron. PMID 27641494 DOI: 10.1016/J.Neuron.2016.08.036  0.708
2016 Pantoja C, Hoagland A, Carroll EC, Karalis V, Conner A, Isacoff EY. Neuromodulatory Regulation of Behavioral Individuality in Zebrafish. Neuron. PMID 27397519 DOI: 10.1016/J.Neuron.2016.06.016  0.778
2016 Chen Y, Bharill S, O'Hagan R, Isacoff EY, Chalfie M. MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans. G3 (Bethesda, Md.). 6: 1121-30. PMID 27172609 DOI: 10.1534/G3.115.023507  0.333
2016 Levitz J, Royal P, Comoglio Y, Wdziekonski B, Schaub S, Clemens DM, Isacoff EY, Sandoz G. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035963 DOI: 10.1073/Pnas.1522459113  0.81
2016 Chen Y, Bharill S, Altun Z, O'Hagan R, Coblitz B, Isacoff EY, Chalfie M. C. elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Molecular Biology of the Cell. PMID 26941331 DOI: 10.1091/Mbc.E15-08-0561  0.352
2016 Berlin S, Szobota S, Reiner A, Carroll EC, Kienzler MA, Guyon A, Xiao T, Tauner D, Isacoff EY. A family of photoswitchable NMDA receptors. Elife. 5. PMID 26929991 DOI: 10.7554/Elife.12040  0.799
2016 Grimm SS, Isacoff EY. Allosteric substrate switching in a voltage-sensing lipid phosphatase. Nature Chemical Biology. PMID 26878552 DOI: 10.1038/nchembio.2022  0.323
2016 Levitz J, Popescu AT, Reiner A, Isacoff EY. A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Frontiers in Molecular Neuroscience. 9: 2. PMID 26869877 DOI: 10.3389/Fnmol.2016.00002  0.78
2016 Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff EY, Baier H, Trauner D. Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) Chemical Science. 7: 2347-2352. DOI: 10.1039/c5sc04084a  0.31
2016 Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff E. Optical Probing of Metabotropic Glutamate Receptors Biophysical Journal. 110: 532a. DOI: 10.1016/J.Bpj.2015.11.2846  0.38
2015 Broichhagen J, Damijonaitis A, Levitz J, Sokol KR, Leippe P, Konrad D, Isacoff EY, Trauner D. Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. Acs Central Science. 1: 383-93. PMID 27162996 DOI: 10.1021/Acscentsci.5B00260  0.698
2015 Palty R, Isacoff EY. Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-Activated Calcium Modulator 1 (Orai1). The Journal of Biological Chemistry. PMID 26546674 DOI: 10.1074/Jbc.M115.685289  0.332
2015 Chen Y, Bharill S, Isacoff EY, Chalfie M. Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 112: 11690-5. PMID 26324944 DOI: 10.1073/Pnas.1515968112  0.401
2015 Vafabakhsh R, Levitz J, Isacoff EY. Conformational dynamics of a class C G-protein-coupled receptor. Nature. 524: 497-501. PMID 26258295 DOI: 10.1038/Nature14679  0.709
2015 Berlin S, Carroll EC, Newman ZL, Okada HO, Quinn CM, Kallman B, Rockwell NC, Martin SS, Lagarias JC, Isacoff EY. Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging. Nature Methods. PMID 26167640 DOI: 10.1038/Nmeth.3480  0.746
2015 Palty R, Stanley C, Isacoff EY. Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating. Cell Research. 25: 963-80. PMID 26138675 DOI: 10.1038/Cr.2015.80  0.351
2015 Mony L, Berger TK, Isacoff EY. A specialized molecular motion opens the Hv1 voltage-gated proton channel. Nature Structural & Molecular Biology. 22: 283-90. PMID 25730777 DOI: 10.1038/Nsmb.2978  0.527
2015 Ball RW, Peled ES, Guerrero G, Isacoff EY. BMP signaling and microtubule organization regulate synaptic strength. Neuroscience. 291: 155-66. PMID 25681521 DOI: 10.1016/J.Neuroscience.2015.01.069  0.697
2015 Carroll EC, Berlin S, Levitz J, Kienzler MA, Yuan Z, Madsen D, Larsen DS, Isacoff EY. Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proceedings of the National Academy of Sciences of the United States of America. 112: E776-85. PMID 25653339 DOI: 10.1073/Pnas.1416942112  0.703
2015 Reiner A, Levitz J, Isacoff EY. Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Current Opinion in Pharmacology. 20: 135-43. PMID 25573450 DOI: 10.1016/J.Coph.2014.12.008  0.768
2015 Berger TK, Isacoff EY. Fluorescent labeling for patch-clamp fluorometry (PCF) measurements of real-time protein motion in ion channels. Methods in Molecular Biology (Clifton, N.J.). 1266: 93-106. PMID 25560069 DOI: 10.1007/978-1-4939-2272-7_6  0.541
2015 Friedmann D, Hoagland A, Berlin S, Isacoff EY. A spinal opsin controls early neural activity and drives a behavioral light response. Current Biology : Cb. 25: 69-74. PMID 25484291 DOI: 10.1016/J.Cub.2014.10.055  0.789
2015 Berlin S, Szobota S, Reiner A, Carroll EC, Kienzler MA, Guyon A, Xiao T, Trauner D, Isacoff EY. Author response: A family of photoswitchable NMDA receptors Elife. DOI: 10.7554/Elife.12040.024  0.772
2015 Palty R, Stanley C, Isacoff E. STIM1 Binding to Both the N' and C' Termini of Orai1 is Critical for Gating of CRAC Channels Biophysical Journal. 108: 129a. DOI: 10.1016/J.Bpj.2014.11.719  0.353
2015 Comoglio Y, Joshua L, Kienzler M, Lesage F, Isacoff E, Sandoz G. Phospholipase D2 Specifically Regulates TREK Channels via Direct Interaction and Local Production of Phosphatidic Acid Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2380  0.703
2015 Levitz J, Vafabakhsh R, Bharill S, Bharill S, Isacoff EY. Assembly and Cooperativity of Metabotropic Glutamate Receptors Biophysical Journal. 108: 416a-417a. DOI: 10.1016/J.Bpj.2014.11.2282  0.366
2015 Vafabakhsh R, Levitz J, Isacoff EY. Confrontational Dynamics of a GPCR Revealed by Single Molecule FRET Biophysical Journal. 108: 3-9. DOI: 10.1016/J.Bpj.2014.11.1915  0.703
2014 Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E5574-83. PMID 25489083 DOI: 10.1073/Pnas.1414162111  0.574
2014 Rullo A, Reiner A, Reiter A, Trauner D, Isacoff EY, Woolley GA. Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative. Chemical Communications (Cambridge, England). 50: 14613-5. PMID 25311049 DOI: 10.1039/C4Cc06612J  0.618
2014 Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proceedings of the National Academy of Sciences of the United States of America. 111: 13547-52. PMID 25197053 DOI: 10.1073/Pnas.1407160111  0.805
2014 Bharill S, Fu Z, Palty R, Isacoff EY. Stoichiometry and specific assembly of Best ion channels. Proceedings of the National Academy of Sciences of the United States of America. 111: 6491-6. PMID 24748110 DOI: 10.1073/Pnas.1400248111  0.393
2014 Reiner A, Isacoff EY. Photoswitching of cell surface receptors using tethered ligands. Methods in Molecular Biology (Clifton, N.J.). 1148: 45-68. PMID 24718794 DOI: 10.1007/978-1-4939-0470-9_4  0.576
2014 Reiner A, Isacoff EY. Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy. Nature Chemical Biology. 10: 273-80. PMID 24561661 DOI: 10.1038/Nchembio.1458  0.592
2014 Peled ES, Newman ZL, Isacoff EY. Evoked and spontaneous transmission favored by distinct sets of synapses. Current Biology : Cb. 24: 484-93. PMID 24560571 DOI: 10.1016/J.Cub.2014.01.022  0.735
2014 Reiner A, Isacoff EY. Probing the Gating of Ionotropic Glutamate Receptors with Tethered Photoswitchable Ligands Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.217  0.595
2014 Kienzler M, Levitz J, Isacoff E. Expanding the Visible Light Photoswitch Library: A Red-Shifted, Fast-Relaxing Azobenzene Photoswitch for Reversible Activation of Metabotropic Glutamate Receptors Biophysical Journal. 106: 380a-381a. DOI: 10.1016/J.Bpj.2013.11.2154  0.719
2014 Levitz J, Bharill S, Vafabakhsh R, Isacoff EY. Optical Probing of Metabotropic Glutamate Receptor Assembly and Cooperativity Biophysical Journal. 106: 20a-21a. DOI: 10.1016/J.Bpj.2013.11.168  0.386
2014 Mony L, Berger TK, Isacoff EY. The Specialized Role of the S1 Transmembrane Segment in the Gating of the Hv1 Proton Channel Biophysical Journal. 106: 233a. DOI: 10.1016/J.Bpj.2013.11.1365  0.546
2014 Vafabakhsh R, Levitz J, Isacoff EY. The Activation Dynamics of Class C Gpcrs Revealed by Single Molecule FRET Biophysical Journal. 106: 194a. DOI: 10.1016/J.Bpj.2013.11.1149  0.707
2013 Isacoff EY, Jan LY, Minor DL. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron. 80: 658-74. PMID 24183018 DOI: 10.1016/J.Neuron.2013.10.040  0.669
2013 Kienzler MA, Reiner A, Trautman E, Yoo S, Trauner D, Isacoff EY. A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor. Journal of the American Chemical Society. 135: 17683-6. PMID 24171511 DOI: 10.1021/Ja408104W  0.576
2013 Reiner A, Isacoff EY. The Brain Prize 2013: the optogenetics revolution. Trends in Neurosciences. 36: 557-60. PMID 24054067 DOI: 10.1016/J.Tins.2013.08.005  0.49
2013 Reiner A, Levitz J, Isacoff E. Bringing optogenetics to the synapse. Neuron. 79: 209-10. PMID 23889927 DOI: 10.1016/J.Neuron.2013.07.009  0.748
2013 Patti J, Isacoff EY. Measuring membrane voltage with fluorescent proteins. Cold Spring Harbor Protocols. 2013: 606-13. PMID 23818671 DOI: 10.1101/pdb.top075804  0.362
2013 Kauwe G, Isacoff EY. Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction. Proceedings of the National Academy of Sciences of the United States of America. 110: 9142-7. PMID 23674684 DOI: 10.1073/Pnas.1221314110  0.786
2013 Hastie P, Ulbrich MH, Wang HL, Arant RJ, Lau AG, Zhang Z, Isacoff EY, Chen L. AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting. Proceedings of the National Academy of Sciences of the United States of America. 110: 5163-8. PMID 23479622 DOI: 10.1073/Pnas.1218765110  0.776
2013 Levitz J, Pantoja C, Gaub B, Janovjak H, Reiner A, Hoagland A, Schoppik D, Kane B, Stawski P, Schier AF, Trauner D, Isacoff EY. Optical control of metabotropic glutamate receptors. Nature Neuroscience. 16: 507-16. PMID 23455609 DOI: 10.1038/Nn.3346  0.804
2013 Kienzler MA, Reiner A, Trauner D, Isacoff E. Synthesis and Characterization of a Red-Shifted, Fast Relaxing, Photoswitchable Tethered Ligand for use in Modified Glutamate Receptors Biophysical Journal. 104: 678a. DOI: 10.1016/J.Bpj.2012.11.3744  0.601
2013 Mony L, Berger TK, Isacoff EY. Gating of the Hv1 Proton Channel Biophysical Journal. 104: 276a. DOI: 10.1016/J.Bpj.2012.11.1546  0.559
2013 Reiner A, Isacoff EY. Fast Photoswitching of Tethered Ligands to Study Ionotropic Glutamate Receptor Activation and Desensitization Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.1523  0.602
2013 Berger TK, Mony L, Isacoff EY. pH-Dependent Conformational Changes of the Voltage-Gated Proton Channel Recorded with Patch Clamp Fluorometry Biophysical Journal. 104: 207a. DOI: 10.1016/J.Bpj.2012.11.1170  0.537
2012 Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff EY, Yang J. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nature Communications. 3: 1252. PMID 23212381 DOI: 10.1038/Ncomms2257  0.755
2012 Sandoz G, Isacoff EY. [Optical remote control of native ion channels]. Mã©Decine Sciences : M/S. 28: 934-7. PMID 23171896 DOI: 10.1051/Medsci/20122811011  0.674
2012 Sandoz G, Levitz J, Kramer RH, Isacoff EY. Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 74: 1005-14. PMID 22726831 DOI: 10.1016/J.Neuron.2012.04.026  0.798
2012 Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff EY, Minor DL. A glutamate switch controls voltage-sensitive phosphatase function. Nature Structural & Molecular Biology. 19: 633-41. PMID 22562138 DOI: 10.1038/Nsmb.2289  0.797
2012 Reiner A, Arant RJ, Isacoff EY. Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Cell Reports. 1: 234-40. PMID 22509486 DOI: 10.1016/J.Celrep.2012.01.003  0.79
2012 Ahrens KF, Heider B, Lee H, Isacoff EY, Siegel RM. Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat. Frontiers in Neural Circuits. 6: 15. PMID 22461770 DOI: 10.3389/Fncir.2012.00015  0.796
2012 Li D, Hérault K, Isacoff EY, Oheim M, Ropert N. Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. The Journal of Physiology. 590: 855-73. PMID 22219341 DOI: 10.1113/Jphysiol.2011.219345  0.34
2012 Warp E, Agarwal G, Wyart C, Friedmann D, Oldfield CS, Conner A, Del Bene F, Arrenberg AB, Baier H, Isacoff EY. Emergence of patterned activity in the developing zebrafish spinal cord. Current Biology : Cb. 22: 93-102. PMID 22197243 DOI: 10.1016/J.Cub.2011.12.002  0.761
2012 Reiner A, Isacoff EY. Activation of Ionotropic Glutamate Receptors using Tethered Photoswitchable Ligands Biophysical Journal. 102: 115. DOI: 10.1016/J.Bpj.2011.11.648  0.61
2012 Bharill S, Isacoff EY. Single Molecule Optical Determination of Bestrophin Stoichiometry Biophysical Journal. 102: 549a-550a. DOI: 10.1016/J.Bpj.2011.11.2998  0.344
2012 Levitz J, Gaub B, Janovjak H, Stawski P, Trauner D, Isacoff E. Optical Control of Metabotropic Glutamate Receptors for Probing of G Protein Signaling and Receptor Activation Mechanism Biophysical Journal. 102: 517a. DOI: 10.1016/J.Bpj.2011.11.2827  0.403
2012 Liu L, Kohout SC, Xu Q, Mueller S, Isacoff EY, Minor D. Internal Switch Gates Phosphatase Activity of VSP Biophysical Journal. 102: 36a-37a. DOI: 10.1016/J.Bpj.2011.11.226  0.797
2012 Yu Y, Ulbrich MH, Dobbins S, Li M, Zhang WK, Tong L, Isacoff EY, Yang J. Molecular and Structural Mechanism of the Assembly of an Acid-Sensing Receptor/Ion Channel Complex Biophysical Journal. 102: 345a. DOI: 10.1016/J.Bpj.2011.11.1889  0.754
2011 Berger TK, Isacoff EY. The pore of the voltage-gated proton channel. Neuron. 72: 991-1000. PMID 22196334 DOI: 10.1016/J.Neuron.2011.11.014  0.537
2011 Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL. Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Channels (Austin, Tex.). 5: 320-4. PMID 21712653 DOI: 10.4161/Chan.5.4.16821  0.783
2011 Zhu J, Yu Y, Ulbrich MH, Li MH, Isacoff EY, Honig B, Yang J. Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proceedings of the National Academy of Sciences of the United States of America. 108: 10133-8. PMID 21642537 DOI: 10.1073/Pnas.1017669108  0.717
2011 Janovjak H, Sandoz G, Isacoff EY. A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence. Nature Communications. 2: 232. PMID 21407198 DOI: 10.1038/Ncomms1231  0.705
2011 Agarwal G, Isacoff E. Specializations of a pheromonal glomerulus in the Drosophila olfactory system. Journal of Neurophysiology. 105: 1711-21. PMID 21289134 DOI: 10.1152/jn.00591.2010  0.46
2011 Sandoz G, Bell SC, Isacoff EY. Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proceedings of the National Academy of Sciences of the United States of America. 108: 2605-10. PMID 21262820 DOI: 10.1073/Pnas.1015788108  0.76
2011 Abuin L, Bargeton B, Ulbrich MH, Isacoff EY, Kellenberger S, Benton R. Functional architecture of olfactory ionotropic glutamate receptors. Neuron. 69: 44-60. PMID 21220098 DOI: 10.1016/J.Neuron.2010.11.042  0.732
2011 Koprowski P, Grajkowski W, Isacoff EY, Kubalski A. Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic β domain as a new gating element. The Journal of Biological Chemistry. 286: 877-88. PMID 20978126 DOI: 10.1074/jbc.M110.176131  0.373
2011 Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY. Density-dependent changes of the stoichiometry of KCNQ1–KCNE1 ion channel complex revealed by direct subunit counting using single molecule imaging Neuroscience Research. 71: e205. DOI: 10.1016/j.neures.2011.07.886  0.716
2011 Zhu J, Yu Y, Ulbrich MH, Li M, Isacoff EY, Honig B, Yang J. A Structural Model of the TRPP2/PKD1 C-Terminal Coiled Coil Complex Obtained by a Combination of Computational and Experimental Approaches Biophysical Journal. 100: 106a. DOI: 10.1016/J.Bpj.2010.12.787  0.726
2011 Kohout SC, Liu L, Xu Q, Isacoff EY, Minor DL. Another Look at Ci-VSP Biophysical Journal. 100: 29a. DOI: 10.1016/J.Bpj.2010.12.361  0.814
2011 Reiner A, Isacoff EY. Mechanistic Studies on Ionotropic Glutamate Receptors Using Tethered Photoswitchable Ligands Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.1677  0.623
2011 Levitz J, Gaub B, Janovjak H, Stawski P, Trauner D, Isacoff EY. Design and Application of a Light-Activated Metabotropic Glutamate Receptor for Optical Control of Intracellular Signaling Pathways Biophysical Journal. 100: 177a. DOI: 10.1016/J.Bpj.2010.12.1188  0.735
2011 Findeisen F, Tolia A, Arant R, Kim EY, Isacoff EY, Minor DL. Calmodulin overexpression does not alter Ca v1.2 function or oligomerization state Channels. 5.  0.762
2010 Heider B, Nathanson JL, Isacoff EY, Callaway EM, Siegel RM. Two-photon imaging of calcium in virally transfected striate cortical neurons of behaving monkey. Plos One. 5: e13829. PMID 21079806 DOI: 10.1371/Journal.Pone.0013829  0.52
2010 Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff EY, Baier H. Filtering of visual information in the tectum by an identified neural circuit. Science (New York, N.Y.). 330: 669-73. PMID 21030657 DOI: 10.1126/Science.1192949  0.631
2010 Nakajo K, Ulbrich MH, Kubo Y, Isacoff EY. Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proceedings of the National Academy of Sciences of the United States of America. 107: 18862-7. PMID 20962273 DOI: 10.1073/pnas.1010354107  0.732
2010 Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff EY, Minor DL. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. The Embo Journal. 29: 3924-38. PMID 20953164 DOI: 10.1038/Emboj.2010.260  0.773
2010 Papagiakoumou E, Anselmi F, Bègue A, de Sars V, Glückstad J, Isacoff EY, Emiliani V. Scanless two-photon excitation of channelrhodopsin-2. Nature Methods. 7: 848-54. PMID 20852649 DOI: 10.1038/nmeth.1505  0.333
2010 Lee H, Dean C, Isacoff E. Alternative splicing of neuroligin regulates the rate of presynaptic differentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11435-46. PMID 20739565 DOI: 10.1523/Jneurosci.2946-10.2010  0.781
2010 Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. The Journal of Biological Chemistry. 285: 34850-63. PMID 20739289 DOI: 10.1074/Jbc.M110.167668  0.771
2010 Janovjak H, Szobota S, Wyart C, Trauner D, Isacoff EY. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nature Neuroscience. 13: 1027-32. PMID 20581843 DOI: 10.1038/Nn.2589  0.814
2010 Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nature Chemical Biology. 6: 369-75. PMID 20364128 DOI: 10.1038/Nchembio.349  0.785
2010 Siegel MS, Isacoff EY. Green fluorescent proteins (GFPs) for measuring voltage. Cold Spring Harbor Protocols. 2010: pdb.top76. PMID 20360380 DOI: 10.1101/pdb.top76  0.348
2010 Szobota S, Isacoff EY. Optical control of neuronal activity. Annual Review of Biophysics. 39: 329-48. PMID 20192766 DOI: 10.1146/Annurev.Biophys.093008.131400  0.782
2010 Tombola F, Ulbrich MH, Kohout SC, Isacoff EY. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nature Structural & Molecular Biology. 17: 44-50. PMID 20023640 DOI: 10.1038/Nsmb.1738  0.811
2010 Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff EY. Correction: Corrigendum: Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP Nature Chemical Biology. 6: 782-782. DOI: 10.1038/Nchembio1010-782A  0.766
2010 Nakajo K, Ulbrich MH, Kubo Y, Isacoff E. Stoichiometry of KCNQ1-KCNE1 Ion Channel Complex is Flexible and Density-Dependent Biophysical Journal. 98: 136a-137a. DOI: 10.1016/J.BPJ.2009.12.737  0.735
2010 Kohout SC, Bell SC, Xu Q, Minor DL, Isacoff E. Does the Linker in Ci-VSP Function as a PI(4,5)P2 Binding Domain? Biophysical Journal. 98: 313a. DOI: 10.1016/J.Bpj.2009.12.1698  0.804
2010 Kim EY, Rumpf C, Van Petegem F, Arant R, Cooley ES, Isacoff EY, Minor DL. Biochemical and Functional Characterization of Crystallographic Ca2+/CaM-Cav1.2 A-C-IQ Complex Dimer Biophysical Journal. 98: 16a. DOI: 10.1016/J.Bpj.2009.12.097  0.802
2009 Tombola F, Ulbrich MH, Isacoff EY. Architecture and gating of Hv1 proton channels. The Journal of Physiology. 587: 5325-9. PMID 19915215 DOI: 10.1113/jphysiol.2009.180265  0.81
2009 Kubo Y, Isacoff EY. Dynamic aspects of functioning membrane proteins. The Journal of Physiology. 587: 5315-6. PMID 19915214 DOI: 10.1113/jphysiol.2009.182113  0.453
2009 Wyart C, Del Bene F, Warp E, Scott EK, Trauner D, Baier H, Isacoff EY. Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature. 461: 407-10. PMID 19759620 DOI: 10.1038/Nature08323  0.766
2009 Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff EY, Yang J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proceedings of the National Academy of Sciences of the United States of America. 106: 11558-63. PMID 19556541 DOI: 10.1073/Pnas.0903684106  0.727
2009 Martos V, Bell SC, Santos E, Isacoff EY, Trauner D, de Mendoza J. Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 106: 10482-6. PMID 19435843 DOI: 10.1073/Pnas.0813396106  0.603
2009 Numano R, Szobota S, Lau AY, Gorostiza P, Volgraf M, Roux B, Trauner D, Isacoff EY. Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proceedings of the National Academy of Sciences of the United States of America. 106: 6814-9. PMID 19342491 DOI: 10.1016/J.Neures.2010.07.2065  0.792
2009 Nakajo K, Ulbrich M, Kubo Y, Isacoff E. 2TP2-04 Density-dependent changes in stoichiometry of KCNQ1 complex(The 47th Annual Meeting of the Biophysical Society of Japan) Seibutsu Butsuri. 49: S48. DOI: 10.2142/biophys.49.S48_3  0.663
2009 Janovjak H, Isacoff E. Design Of A Potassium Selective, Light-gated Glutamate Receptor Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.2524  0.44
2009 Szobota S, Numano R, Wyart C, Gorostiza P, Volgraf M, Fortin DL, Del Bene F, Scott EK, Kramer RH, Trauner D, Isacoff EY. Engineering light-gated glutamate receptors Biophysical Journal. 96: 489a. DOI: 10.1016/J.Bpj.2008.12.2523  0.802
2009 Jin L, Baker B, Cohen L, Roman C, Pieribone V, Pralle A, Isacoff E, Mealer R, Hughes T. Random Insertion of Split-can Venus into Kv1.4 Yields Voltage Sensitive Fluorescent Probes Biophysical Journal. 96: 403a. DOI: 10.1016/j.bpj.2008.12.2049  0.685
2009 Kohout SC, Bell SC, Isacoff EY. Probing Protein Motions and Function in Ci-VSP Biophysical Journal. 96: 370a. DOI: 10.1016/J.Bpj.2008.12.1991  0.796
2008 Marriott G, Mao S, Sakata T, Ran J, Jackson DK, Petchprayoon C, Gomez TJ, Warp E, Tulyathan O, Aaron HL, Isacoff EY, Yan Y. Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 17789-94. PMID 19004775 DOI: 10.1073/Pnas.0808882105  0.764
2008 Kohout SC, Isacoff EY. To dislodge an enzyme from an ion channel, try steroids. Nature Chemical Biology. 4: 650-1. PMID 18936745 DOI: 10.1038/Nchembio1108-650  0.77
2008 Gorostiza P, Isacoff EY. Optical switches for remote and noninvasive control of cell signaling. Science (New York, N.Y.). 322: 395-9. PMID 18927384 DOI: 10.1126/science.1166022  0.302
2008 Gorostiza P, Isacoff EY. Nanoengineering ion channels for optical control. Physiology (Bethesda, Md.). 23: 238-47. PMID 18927200 DOI: 10.1152/physiol.00018.2008  0.338
2008 Ulbrich MH, Isacoff EY. Rules of engagement for NMDA receptor subunits. Proceedings of the National Academy of Sciences of the United States of America. 105: 14163-8. PMID 18779583 DOI: 10.1073/pnas.0802075105  0.716
2008 Baker BJ, Mutoh H, Dimitrov D, Akemann W, Perron A, Iwamoto Y, Jin L, Cohen LB, Isacoff EY, Pieribone VA, Hughes T, Knöpfel T. Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biology. 36: 53-67. PMID 18679801 DOI: 10.1007/S11068-008-9026-7  0.326
2008 Pautot S, Wyart C, Isacoff EY. Colloid-guided assembly of oriented 3D neuronal networks. Nature Methods. 5: 735-40. PMID 18641658 DOI: 10.1038/Nmeth.1236  0.646
2008 Tombola F, Ulbrich MH, Isacoff EY. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 58: 546-56. PMID 18498736 DOI: 10.1016/j.neuron.2008.03.026  0.811
2008 Kohout SC, Ulbrich MH, Bell SC, Isacoff EY. Subunit organization and functional transitions in Ci-VSP. Nature Structural & Molecular Biology. 15: 106-8. PMID 18084307 DOI: 10.1038/Nsmb1320  0.802
2008 Wang S, Wang Y, Szobota S, Volgraf M, Liu Z, Sun C, Trauner D, Isacoff EY, Zhang X. All optical platform for parallel and spatiotemporal control of neuronal activity Optics Infobase Conference Papers. DOI: 10.1364/Fio.2008.Ftul4  0.771
2007 Wang S, Szobota S, Wang Y, Volgraf M, Liu Z, Sun C, Trauner D, Isacoff EY, Zhang X. All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Letters. 7: 3859-63. PMID 18034506 DOI: 10.1021/Nl072783T  0.767
2007 Stowers RS, Isacoff EY. Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12874-83. PMID 18032660 DOI: 10.1523/JNEUROSCI.2464-07.2007  0.322
2007 Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff EY. Closing in on the resting state of the Shaker K(+) channel. Neuron. 56: 124-40. PMID 17920020 DOI: 10.1016/J.Neuron.2007.09.023  0.811
2007 Gorostiza P, Isacoff E. Optical switches and triggers for the manipulation of ion channels and pores. Molecular Biosystems. 3: 686-704. PMID 17882331 DOI: 10.1039/b710287a  0.398
2007 Gorostiza P, Volgraf M, Numano R, Szobota S, Trauner D, Isacoff EY. Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proceedings of the National Academy of Sciences of the United States of America. 104: 10865-70. PMID 17578923 DOI: 10.1073/Pnas.0701274104  0.79
2007 Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, ... Isacoff EY, et al. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron. 54: 535-45. PMID 17521567 DOI: 10.1016/J.Neuron.2007.05.010  0.787
2007 Miller EW, Tulyathan O, Tulyanthan O, Isacoff EY, Chang CJ. Molecular imaging of hydrogen peroxide produced for cell signaling. Nature Chemical Biology. 3: 263-7. PMID 17401379 DOI: 10.1038/Nchembio871  0.771
2007 Ulbrich MH, Isacoff EY. Subunit counting in membrane-bound proteins. Nature Methods. 4: 319-21. PMID 17369835 DOI: 10.1038/nmeth1024  0.703
2007 Volgraf M, Gorostiza P, Szobota S, Helix MR, Isacoff EY, Trauner D. Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors. Journal of the American Chemical Society. 129: 260-1. PMID 17212390 DOI: 10.1021/Ja067269O  0.756
2007 Tombola F, Pathak MM, Gorostiza P, Isacoff EY. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 445: 546-9. PMID 17187057 DOI: 10.1038/nature05396  0.772
2007 Baker BJ, Lee H, Pieribone VA, Cohen LB, Isacoff EY, Knopfel T, Kosmidis EK. Three fluorescent protein voltage sensors exhibit low plasma membrane expression in mammalian cells. Journal of Neuroscience Methods. 161: 32-8. PMID 17126911 DOI: 10.1016/J.Jneumeth.2006.10.005  0.798
2007 Miller EW, Tulyathan O, Isacoff EY, Chang CJ. Corrigendum: Molecular imaging of hydrogen peroxide produced for cell signaling Nature Chemical Biology. 3: 349-349. DOI: 10.1038/Nchembio0607-349  0.76
2006 Tombola F, Pathak MM, Isacoff EY. How does voltage open an ion channel? Annual Review of Cell and Developmental Biology. 22: 23-52. PMID 16704338 DOI: 10.1146/annurev.cellbio.21.020404.145837  0.779
2006 Kaláb P, Pralle A, Isacoff EY, Heald R, Weis K. Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature. 440: 697-701. PMID 16572176 DOI: 10.1038/Nature04589  0.632
2006 Volgraf M, Gorostiza P, Numano R, Kramer RH, Isacoff EY, Trauner D. Allosteric control of an ionotropic glutamate receptor with an optical switch. Nature Chemical Biology. 2: 47-52. PMID 16408092 DOI: 10.1038/Nchembio756  0.426
2006 Zeng L, Miller EW, Pralle A, Isacoff EY, Chang CJ. A selective turn-on fluorescent sensor for imaging copper in living cells. Journal of the American Chemical Society. 128: 10-1. PMID 16390096 DOI: 10.1021/Ja055064U  0.635
2005 Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff EY. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. Ieee Transactions On Nanobioscience. 4: 269-76. PMID 16433292 DOI: 10.1109/Tnb.2005.859552  0.669
2005 Pautot S, Lee H, Isacoff EY, Groves JT. Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Nature Chemical Biology. 1: 283-9. PMID 16408058 DOI: 10.1038/Nchembio737  0.785
2005 Tombola F, Pathak MM, Isacoff EY. How far will you go to sense voltage? Neuron. 48: 719-25. PMID 16337910 DOI: 10.1016/j.neuron.2005.11.024  0.771
2005 Miller EW, Albers AE, Pralle A, Isacoff EY, Chang CJ. Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. Journal of the American Chemical Society. 127: 16652-9. PMID 16305254 DOI: 10.1021/Ja054474F  0.642
2005 Baksh MM, Dean C, Pautot S, DeMaria S, Isacoff E, Groves JT. Neuronal activation by GPI-linked neuroligin-1 displayed in synthetic lipid bilayer membranes. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 10693-8. PMID 16262338 DOI: 10.1021/La051243D  0.626
2005 Guerrero G, Reiff DF, Rieff DF, Agarwal G, Ball RW, Borst A, Goodman CS, Isacoff EY. Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nature Neuroscience. 8: 1188-96. PMID 16116446 DOI: 10.1038/Nn1526  0.78
2005 Gandhi CS, Isacoff EY. Shedding light on membrane proteins. Trends in Neurosciences. 28: 472-9. PMID 16043238 DOI: 10.1016/J.Tins.2005.07.005  0.742
2005 Reiff DF, Ihring A, Guerrero G, Isacoff EY, Joesch M, Nakai J, Borst A. In vivo performance of genetically encoded indicators of neural activity in flies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4766-78. PMID 15888652 DOI: 10.1523/JNEUROSCI.4900-04.2005  0.3
2005 Tombola F, Pathak MM, Isacoff EY. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 45: 379-88. PMID 15694325 DOI: 10.1016/j.neuron.2004.12.047  0.764
2005 Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff EY, Jan LY. A fluorescent probe designed for studying protein conformational change. Proceedings of the National Academy of Sciences of the United States of America. 102: 965-70. PMID 15657131 DOI: 10.1073/Pnas.0409469102  0.79
2005 Pathak M, Kurtz L, Tombola F, Isacoff E. The cooperative voltage sensor motion that gates a potassium channel. The Journal of General Physiology. 125: 57-69. PMID 15623895 DOI: 10.1085/jgp.200409197  0.776
2005 Guerrero G, Rieff DF, Agarwal G, Ball RW, Borst A, Goodman CS, Isacoff EY. Erratum: Heterogeneity in synaptic transmission along a Drosophila larval motor axon Nature Neuroscience. 8: 1411-1411. DOI: 10.1038/nn1005-1411a  0.748
2004 Chang MC, Pralle A, Isacoff EY, Chang CJ. A selective, cell-permeable optical probe for hydrogen peroxide in living cells. Journal of the American Chemical Society. 126: 15392-3. PMID 15563161 DOI: 10.1021/Ja0441716  0.633
2004 Banghart M, Borges K, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nature Neuroscience. 7: 1381-6. PMID 15558062 DOI: 10.1038/Nn1356  0.417
2003 Gandhi CS, Clark E, Loots E, Pralle A, Isacoff EY. The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron. 40: 515-25. PMID 14642276 DOI: 10.1016/S0896-6273(03)00646-9  0.799
2003 Gradl SN, Felix JP, Isacoff EY, Garcia ML, Trauner D. Protein surface recognition by rational design: nanomolar ligands for potassium channels. Journal of the American Chemical Society. 125: 12668-9. PMID 14558789 DOI: 10.1021/Ja036155Z  0.327
2003 Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nature Neuroscience. 6: 708-16. PMID 12796785 DOI: 10.1038/Nn1074  0.617
2003 Sonnleitner A, Isacoff E. Single ion channel imaging. Methods in Enzymology. 361: 304-19. PMID 12624917 DOI: 10.1016/S0076-6879(03)61016-5  0.392
2003 Gandhi CS, Isacoff EY. How Do Voltage-Gated Channels Sense the Membrane Potential? Handbook of Cell Signaling. 1: 209-214. DOI: 10.1016/B978-012124546-7/50396-X  0.74
2002 Guerrero G, Siegel MS, Roska B, Loots E, Isacoff EY. Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential. Biophysical Journal. 83: 3607-18. PMID 12496128 DOI: 10.1016/S0006-3495(02)75361-7  0.809
2002 Schönherr R, Mannuzzu LM, Isacoff EY, Heinemann SH. Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron. 35: 935-49. PMID 12372287 DOI: 10.1016/S0896-6273(02)00869-3  0.349
2002 Gandhi CS, Isacoff EY. Molecular models of voltage sensing. The Journal of General Physiology. 120: 455-63. PMID 12356848 DOI: 10.1085/Jgp.20028678  0.743
2002 Sonnleitner A, Mannuzzu LM, Terakawa S, Isacoff EY. Structural rearrangements in single ion channels detected optically in living cells. Proceedings of the National Academy of Sciences of the United States of America. 99: 12759-64. PMID 12228726 DOI: 10.1073/pnas.192261499  0.406
2001 Guerrero G, Isacoff EY. Genetically encoded optical sensors of neuronal activity and cellular function. Current Opinion in Neurobiology. 11: 601-7. PMID 11595495 DOI: 10.1016/S0959-4388(00)00256-7  0.338
2000 Loots E, Isacoff EY. Molecular coupling of S4 to a K(+) channel's slow inactivation gate. The Journal of General Physiology. 116: 623-36. PMID 11055991 DOI: 10.1085/Jgp.116.5.623  0.804
2000 Gandhi CS, Loots E, Isacoff EY. Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel. Neuron. 27: 585-95. PMID 11055440 DOI: 10.1016/S0896-6273(00)00068-4  0.808
2000 Siegel MS, Isacoff EY. Green fluorescent protein-based sensors for detecting signal transduction and monitoring ion channel function. Methods in Enzymology. 327: 249-59. PMID 11044988 DOI: 10.1016/S0076-6879(00)27281-9  0.355
2000 Mannuzzu LM, Isacoff EY. Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence. The Journal of General Physiology. 115: 257-68. PMID 10694254 DOI: 10.1085/jgp.115.3.257  0.375
1999 Glauner KS, Mannuzzu LM, Gandhi CS, Isacoff EY. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature. 402: 813-7. PMID 10617202 DOI: 10.1038/45561  0.77
1999 Zito K, Parnas D, Fetter RD, Isacoff EY, Goodman CS. Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila. Neuron. 22: 719-29. PMID 10230792 DOI: 10.1016/S0896-6273(00)80731-X  0.743
1998 Loots E, Isacoff EY. Protein rearrangements underlying slow inactivation of the Shaker K+ channel. The Journal of General Physiology. 112: 377-89. PMID 9758858 DOI: 10.1085/Jgp.112.4.377  0.812
1998 Baker OS, Larsson HP, Mannuzzu LM, Isacoff EY. Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron. 20: 1283-94. PMID 9655514 DOI: 10.1016/S0896-6273(00)80507-3  0.809
1998 Harris RE, Larsson HP, Isacoff EY. A permanent ion binding site located between two gates of the Shaker K+ channel. Biophysical Journal. 74: 1808-20. PMID 9545043 DOI: 10.1016/S0006-3495(98)77891-9  0.692
1998 Terakawa S, Feller MB, Mannuzzu LM, Isacoff EY. Single fluorophore visualization of ion channel gating by evanescence microscopy Neuroscience Research. 31: S60. DOI: 10.1016/S0168-0102(98)81818-X  0.625
1997 Zito K, Fetter RD, Goodman CS, Isacoff EY. Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron. 19: 1007-16. PMID 9390515 DOI: 10.1016/S0896-6273(00)80393-1  0.75
1997 Siegel MS, Isacoff EY. A genetically encoded optical probe of membrane voltage. Neuron. 19: 735-41. PMID 9354320 DOI: 10.1016/S0896-6273(00)80955-1  0.372
1996 Harris RE, Isacoff EY. Hydrophobic mutations alter the movement of Mg2+ in the pore of voltage-gated potassium channels. Biophysical Journal. 71: 209-19. PMID 8804604 DOI: 10.1016/S0006-3495(96)79217-2  0.525
1996 Larsson HP, Baker OS, Dhillon DS, Isacoff EY. Transmembrane movement of the shaker K+ channel S4. Neuron. 16: 387-97. PMID 8789953 DOI: 10.1016/S0896-6273(00)80056-2  0.803
1996 Mannuzzu LM, Moronne MM, Isacoff EY. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science (New York, N.Y.). 271: 213-6. PMID 8539623 DOI: 10.1126/Science.271.5247.373  0.406
1993 Li M, Isacoff E, Jan YN, Jan LY. Assembly of potassium channels. Annals of the New York Academy of Sciences. 707: 51-9. PMID 9137541 DOI: 10.1111/j.1749-6632.1993.tb38041.x  0.521
1993 Isacoff EY, Jan YN, Jan LY. Molecular basis of K+ channel inactivation gating. Exs. 63: 338-51. PMID 8380732 DOI: 10.1007/978-3-0348-7265-2_18  0.571
1992 Baldwin TJ, Isacoff E, Li M, Lopez GA, Sheng M, Tsaur ML, Yan YN, Jan LY. Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harbor Symposia On Quantitative Biology. 57: 491-9. PMID 1339685 DOI: 10.1101/Sqb.1992.057.01.054  0.545
1991 Isacoff EY, Jan YN, Jan LY. Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature. 353: 86-90. PMID 1881453 DOI: 10.1038/353086a0  0.551
1990 Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY. Molecular studies of voltage-gated potassium channels. Cold Spring Harbor Symposia On Quantitative Biology. 55: 9-17. PMID 2132867 DOI: 10.1101/Sqb.1990.055.01.004  0.558
1990 Isacoff EY, Jan YN, Jan LY. Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature. 345: 530-4. PMID 2112229 DOI: 10.1038/345530a0  0.537
1988 Birks RI, Isacoff EY. Burst-patterned stimulation promotes nicotinic transmission in isolated perfused rat sympathetic ganglia. The Journal of Physiology. 402: 515-32. PMID 2907049 DOI: 10.1113/Jphysiol.1988.Sp017218  0.694
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