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Eileen H. Bigio, MD, University of Texas Medical Branch, MSc - Publications

Affiliations: 
Pathology Northwestern University, Evanston, IL 
Area:
Alzheimer's disease and related disorders
Website:
http://www.pathology.northwestern.edu/Faculty/FacultyBio.cfm?ID=2
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Year Citation  Score
2024 Kawles A, Keszycki R, Minogue G, Zouridakis A, Ayala I, Gill N, Macomber A, Lubbat V, Coventry C, Rogalski E, Weintraub S, Mao Q, Flanagan ME, Zhang H, Castellani R, ... Bigio EH, et al. Phenotypically concordant distribution of pick bodies in aphasic versus behavioral dementias. Acta Neuropathologica Communications. 12: 31. PMID 38389095 DOI: 10.1186/s40478-024-01738-7  0.355
2023 Minogue G, Kawles A, Zouridakis A, Keszycki R, Macomber A, Lubbat V, Gill N, Mao Q, Flanagan ME, Zhang H, Castellani R, Bigio EH, Mesulam MM, Geula C, Gefen T. Distinct Patterns of Hippocampal Pathology in Alzheimer's Disease with TDP-43. Annals of Neurology. PMID 37592884 DOI: 10.1002/ana.26762  0.578
2023 Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, ... ... Bigio EH, et al. Creating the Pick's disease International Consortium: Association study of H2 haplotype with risk of Pick's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37163045 DOI: 10.1101/2023.04.17.23288471  0.68
2023 Kawles A, Minogue G, Zouridakis A, Keszycki R, Gill N, Nassif C, Coventry C, Zhang H, Rogalski E, Flanagan ME, Castellani R, Bigio EH, Mesulam MM, Geula C, Gefen T. Differential vulnerability of the dentate gyrus to tauopathies in dementias. Acta Neuropathologica Communications. 11: 1. PMID 36597124 DOI: 10.1186/s40478-022-01485-7  0.399
2022 Multz RA, Spencer C, Matos A, Ajroud K, Zamudio C, Bigio E, Mao Q, Medeiros RA, Ahrendsen JT, Castellani RJ, Flanagan ME. What every neuropathologist needs to know: condensed protocol work-up for clinical dementia syndromes. Journal of Neuropathology and Experimental Neurology. PMID 36458947 DOI: 10.1093/jnen/nlac114  0.559
2022 Nassif C, Kawles A, Ayala I, Minogue G, Gill NP, Shepard RA, Zouridakis A, Keszycki R, Zhang H, Mao Q, Flanagan ME, Bigio EH, Mesulam MM, Rogalski E, Geula C, et al. Integrity of neuronal size in the entorhinal cortex is a biologic substrate of exceptional cognitive aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36180225 DOI: 10.1523/JNEUROSCI.0679-22.2022  0.458
2022 Mesulam MM, Coventry CA, Bigio EH, Sridhar J, Gill N, Fought AJ, Zhang H, Thompson CK, Geula C, Gefen T, Flanagan M, Mao Q, Weintraub S, Rogalski EJ. Neuropathological fingerprints of survival, atrophy and language in primary progressive aphasia. Brain : a Journal of Neurology. PMID 35441216 DOI: 10.1093/brain/awab410  0.506
2021 Kawles A, Nishihira Y, Feldman A, Gill N, Minogue G, Keszycki R, Coventry C, Spencer C, Lilek J, Ajroud K, Coppola G, Rademakers R, Rogalski E, Weintraub S, Zhang H, ... ... Bigio EH, et al. Cortical and subcortical pathological burden and neuronal loss in an autopsy series of FTLD-TDP-type C. Brain : a Journal of Neurology. PMID 34919645 DOI: 10.1093/brain/awab368  0.488
2021 Iida MA, Farrell K, Walker JM, Richardson TE, Marx GA, Bryce CH, Purohit D, Ayalon G, Beach TG, Bigio EH, Cortes EP, Gearing M, Haroutunian V, McMillan CT, Lee EB, et al. Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study. Acta Neuropathologica Communications. 9: 134. PMID 34353357 DOI: 10.1186/s40478-021-01233-3  0.751
2021 Josephs KA, Duffy JR, Clark HM, Utianski RL, Strand EA, Machulda MM, Botha H, Martin PR, Pham NTT, Stierwalt J, Ali F, Buciuc M, Baker M, Fernandez De Castro CH, Spychalla AJ, ... ... Bigio EH, et al. A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. Nature Communications. 12: 3452. PMID 34103532 DOI: 10.1038/s41467-021-23687-8  0.594
2021 Qiu C, Albayram O, Kondo A, Wang B, Kim N, Arai K, Tsai CY, Bassal MA, Herbert MK, Washida K, Angeli P, Kozono S, Stucky JE, Baxley S, Lin YM, ... ... Bigio EH, et al. Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice. Science Translational Medicine. 13. PMID 34078745 DOI: 10.1126/scitranslmed.aaz7615  0.304
2021 Gefen T, Kawles A, Makowski-Woidan B, Engelmeyer J, Ayala I, Abbassian P, Zhang H, Weintraub S, Flanagan ME, Mao Q, Bigio EH, Rogalski E, Mesulam MM, Geula C. Paucity of Entorhinal Cortex Pathology of the Alzheimer's Type in SuperAgers with Superior Memory Performance. Cerebral Cortex (New York, N.Y. : 1991). PMID 33592091 DOI: 10.1093/cercor/bhaa409  0.535
2021 Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, ... ... Bigio EH, et al. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics. PMID 33589841 DOI: 10.1038/s41588-021-00785-3  0.474
2021 Mesulam MM, Coventry C, Kuang A, Bigio EH, Mao Q, Flanagan ME, Gefen T, Sridhar J, Geula C, Zhang H, Weintraub S, Rogalski EJ. Memory resilience in Alzheimer's disease with primary progressive aphasia. Neurology. PMID 33441454 DOI: 10.1212/WNL.0000000000011397  0.462
2021 Burbulla LF, Mc Donald JM, Valdez C, Gao F, Bigio EH, Krainc D. Modeling Brain Pathology of Niemann-Pick Disease Type C Using Patient-Derived Neurons. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33438272 DOI: 10.1002/mds.28463  0.304
2020 Walker JM, Richardson TE, Farrell K, Iida MA, Foong C, Shang P, Attems J, Ayalon G, Beach TG, Bigio EH, Budson A, Cairns NJ, Corrada M, Cortes E, Dickson DW, et al. Early Selective Vulnerability of the CA2 Hippocampal Subfield in Primary Age-Related Tauopathy. Journal of Neuropathology and Experimental Neurology. PMID 33367843 DOI: 10.1093/jnen/nlaa153  0.77
2020 Buciuc M, Whitwell JL, Kasanuki K, Graff-Radford J, Machulda MM, Duffy JR, Strand EA, Lowe VJ, Graff-Radford NR, Rush BK, Franczak MB, Flanagan ME, Baker MC, Rademakers R, Ross OA, ... ... Bigio EH, et al. Lewy body disease is a contributor to logopenic progressive aphasia phenotype. Annals of Neurology. PMID 33274526 DOI: 10.1002/ana.25979  0.602
2020 Gefen T, Mao Q, Kohler M, Moeller S, Kawles A, Coventry C, Spencer C, Lilek J, Ajroud K, Feldman A, Flanagan M, Rogalski E, Weintraub S, Rademaker A, Geula C, ... ... Bigio E, et al. Primary Progressive Aphasia has a Unique Signature Distinct from Dementia of the Alzheimer's Type and Behavioral Variant Frontotemporal Dementia Regardless of Pathology. Journal of Neuropathology and Experimental Neurology. PMID 33068393 DOI: 10.1093/jnen/nlaa080  0.53
2020 Ohm DT, Fought AJ, Martersteck A, Coventry C, Sridhar J, Gefen T, Weintraub S, Bigio E, Mesulam MM, Rogalski E, Geula C. Accumulation of neurofibrillary tangles and activated microglia is associated with lower neuron densities in the aphasic variant of Alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 33010092 DOI: 10.1111/bpa.12902  0.309
2020 Lamerand S, Shahidehpour R, Ayala I, Gefen T, Mesulam MM, Bigio E, Geula C. Calbindin-D, parvalbumin, and calretinin in young and aged human locus coeruleus. Neurobiology of Aging. 94: 243-249. PMID 32663717 DOI: 10.1016/J.Neurobiolaging.2020.06.006  0.34
2020 McCord MR, Bigio EH, Kam KL, Fischer V, Obeidin F, White CL, Brat DJ, Muller WA, Mao Q. Spinocerebellar Ataxia Type 3: A Case Report and Literature Review. Journal of Neuropathology and Experimental Neurology. PMID 32346735 DOI: 10.1093/Jnen/Nlaa033  0.557
2020 Lee DJ, Bigio EH, Rogalski EJ, Mesulam MM. Speech and Language Presentations of FTLD-TDP Type B Neuropathology. Journal of Neuropathology and Experimental Neurology. PMID 31995205 DOI: 10.1093/Jnen/Nlz132  0.386
2019 Weintraub S, Teylan M, Rader B, Chan KCG, Bollenbeck M, Kukull WA, Coventry C, Rogalski E, Bigio E, Mesulam MM. is a correlate of phenotypic heterogeneity in Alzheimer disease in a national cohort. Neurology. PMID 31704790 DOI: 10.1212/Wnl.0000000000008666  0.454
2019 Jara JH, Gautam M, Kocak N, Xie EF, Mao Q, Bigio EH, Özdinler PH. MCP1-CCR2 and neuroinflammation in the ALS motor cortex with TDP-43 pathology. Journal of Neuroinflammation. 16: 196. PMID 31666087 DOI: 10.1186/S12974-019-1589-Y  0.507
2019 Ohm DT, Fought AJ, Rademaker A, Kim G, Sridhar J, Coventry C, Gefen T, Weintraub S, Bigio E, Mesulam MM, Rogalski E, Geula C. Neuropathologic basis of in vivo cortical atrophy in the aphasic variant of alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 31446630 DOI: 10.1111/Bpa.12783  0.398
2019 Mao Q, Zheng X, Gefen T, Rogalski E, Spencer CL, Rademakers R, Fought AJ, Kohler M, Weintraub S, Xia H, Mesulam MM, Bigio EH. FTLD-TDP With and Without GRN Mutations Cause Different Patterns of CA1 Pathology. Journal of Neuropathology and Experimental Neurology. PMID 31361008 DOI: 10.1093/Jnen/Nlz059  0.465
2019 Borges LG, Rademaker AW, Bigio EH, Mesulam MM, Weintraub S. Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias. American Journal of Alzheimer's Disease and Other Dementias. 1533317519853466. PMID 31170813 DOI: 10.1177/1533317519853466  0.351
2019 Apple AC, Mao Q, Bigio E, Bonakdarpour B. Sleep talking and primary progressive aphasia: case study and autopsy findings in a patient with logopenic primary progressive aphasia and dementia with Lewy bodies. Bmj Case Reports. 12. PMID 31133550 DOI: 10.1136/Bcr-2018-228938  0.474
2019 Nishihira Y, Gefen T, Mao Q, Appin C, Kohler M, Walker J, Rademakers R, Rademaker A, Rogalski E, Weintraub S, Geula C, Mesulam MM, Bigio EH. Revisiting the utility of TDP-43 immunoreactive (TDP-43-ir) pathology to classify FTLD-TDP subtypes. Acta Neuropathologica. PMID 31065833 DOI: 10.1007/S00401-019-02024-W  0.679
2019 Li Y, Wang D, Li Y, Zhu J, Zhao J, Deng Y, Rogalski EJ, Bigio EH, Rademaker AW, Xia H, Mao Q. A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders. Journal of Neuropathology and Experimental Neurology. PMID 30939191 DOI: 10.1093/Jnen/Nlz022  0.413
2019 Rogalski EJ, Sridhar J, Martersteck A, Rader B, Cobia D, Arora AK, Fought AJ, Bigio EH, Weintraub S, Mesulam MM, Rademaker A. Clinical and cortical decline in the aphasic variant of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30765195 DOI: 10.1016/J.Jalz.2018.12.003  0.302
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Bigio EH, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9  0.642
2019 Walker JM, Richardson T, Farrell KW, Fudym Y, Woltjer R, Seshadri S, Bigio EH, White C, Crary JF. O2-08-06: CA2 NEUROFIBRILLARY DEGENERATION AND ASYMMETRY IN PRIMARY AGE-RELATED TAUOPATHY Alzheimer's & Dementia. 15: P557-P558. DOI: 10.1016/J.Jalz.2019.06.4498  0.552
2018 Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Miller ZA, Karydas AM, Bigio EH, Rogalski E, Weintraub S, Rader B, Miller BL, Gorno-Tempini ML, Mesulam MM, et al. Genetic screen in a large series of patients with primary progressive aphasia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30599136 DOI: 10.1016/J.Jalz.2018.10.009  0.307
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Bigio EH, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.664
2018 Gefen T, Ahmadian SS, Mao Q, Kim G, Seckin M, Bonakdarpour B, Ramos EM, Coppola G, Rademakers R, Rogalski E, Rademaker A, Weintraub S, Mesulam MM, Geula C, Bigio EH. Combined Pathologies in FTLD-TDP Types A and C. Journal of Neuropathology and Experimental Neurology. PMID 29584904 DOI: 10.1093/Jnen/Nly018  0.542
2018 Rogalski E, Gefen T, Mao Q, Connelly M, Weintraub S, Geula C, Bigio EH, Mesulam MM. Cognitive trajectories and spectrum of neuropathology in SuperAgers: The first ten cases. Hippocampus. PMID 29341318 DOI: 10.1002/Hipo.22828  0.461
2017 Hirsch-Reinshagen V, Pottier C, Nicholson AM, Baker M, Hsiung GR, Krieger C, Sengdy P, Boylan KB, Dickson DW, Mesulam M, Weintraub S, Bigio E, Zinman L, Keith J, Rogaeva E, et al. Clinical and neuropathological features of ALS/FTD with TIA1 mutations. Acta Neuropathologica Communications. 5: 96. PMID 29216908 DOI: 10.1017/Cjn.2018.48  0.301
2017 Gefen T, Papastefan ST, Rezvanian A, Bigio EH, Weintraub S, Rogalski E, Mesulam MM, Geula C. Von Economo neurons of the anterior cingulate across the lifespan and in Alzheimer's disease. Cortex; a Journal Devoted to the Study of the Nervous System and Behavior. 99: 69-77. PMID 29175073 DOI: 10.1016/J.Cortex.2017.10.015  0.313
2017 Mao Q, Wang D, Li Y, Kohler M, Wilson J, Parton Z, Shmaltsuyeva B, Gursel D, Rademakers R, Weintraub S, Mesulam MM, Xia H, Bigio EH. Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration. Journal of Neuropathology and Experimental Neurology. 76: 957-968. PMID 29044416 DOI: 10.1093/Jnen/Nlx085  0.493
2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology. PMID 28591867 DOI: 10.1093/Jnen/Nlx041  0.443
2017 Lopez A, Lee SE, Wojta K, Ramos EM, Klein E, Chen J, Boxer AL, Gorno-Tempini ML, Geschwind DH, Schlotawa L, Ogryzko NV, Bigio EH, Rogalski E, Weintraub S, Mesulam MM, et al. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain : a Journal of Neurology. PMID 28334843 DOI: 10.1093/Brain/Awx005  0.388
2017 Oboudiyat C, Gefen T, Varelas E, Weintraub S, Rogalski E, Bigio EH, Mesulam MM. Cerebrospinal fluid markers detect Alzheimer's disease in nonamnestic dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28196768 DOI: 10.1016/J.Jalz.2017.01.006  0.317
2016 Hakar M, Chandler JP, Bigio EH, Mao Q. Neuroendocrine carcinoma of the pineal parenchyma. The first reported case. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. PMID 27742368 DOI: 10.1016/J.Jocn.2016.09.024  0.426
2016 Guo L, Rezvanian A, Kukreja L, Hoveydai R, Bigio EH, Mesulam MM, El Khoury J, Geula C. Postmortem Adult Human Microglia Proliferate in Culture to High Passage and Maintain Their Response to Amyloid-β. Journal of Alzheimer's Disease : Jad. PMID 27567845 DOI: 10.3233/Jad-160394  0.304
2016 Rogalski E, Sridhar J, Rader B, Martersteck A, Chen K, Cobia D, Thompson CK, Weintraub S, Bigio EH, Mesulam MM. Aphasic variant of Alzheimer disease: Clinical, anatomic, and genetic features. Neurology. PMID 27566743 DOI: 10.1212/Wnl.0000000000003165  0.456
2016 Kielb S, Cook A, Wieneke C, Rademaker A, Bigio EH, Mesulam MM, Rogalski E, Weintraub S. Neuropathologic Associations of Learning and Memory in Primary Progressive Aphasia. Jama Neurology. PMID 27183206 DOI: 10.1001/Jamaneurol.2016.0880  0.357
2016 Ringman JM, Monsell S, Ng DW, Zhou Y, Nguyen A, Coppola G, Van Berlo V, Mendez MF, Tung S, Weintraub S, Mesulam MM, Bigio EH, Gitelman DR, Fisher-Hubbard AO, Albin RL, et al. Neuropathology of Autosomal Dominant Alzheimer Disease in the National Alzheimer Coordinating Center Database. Journal of Neuropathology and Experimental Neurology. PMID 26888304 DOI: 10.1093/Jnen/Nlv028  0.487
2015 Ernst LM, Bit-Ivan EN, Miller ES, Minturn L, Bigio EH, Weese-Meyer DE. Stillbirth: Correlations Between Brain Injury and Placental Pathology. Pediatric and Developmental Pathology : the Official Journal of the Society For Pediatric Pathology and the Paediatric Pathology Society. PMID 26492345 DOI: 10.2350/15-06-1658-Oa.1  0.344
2015 Ahmadian SS, Rezvanian A, Peterson M, Weintraub S, Bigio EH, Mesulam MM, Geula C. Loss of calbindin-D28K is associated with the full range of tangle pathology within basal forebrain cholinergic neurons in Alzheimer's disease. Neurobiology of Aging. PMID 26417681 DOI: 10.1016/J.Neurobiolaging.2015.09.001  0.465
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/J.Jalz.2015.07.492  0.407
2015 Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C. Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease. Brain : a Journal of Neurology. 138: 1722-37. PMID 25732182 DOI: 10.1093/Brain/Awv024  0.42
2015 Gefen T, Peterson M, Papastefan ST, Martersteck A, Whitney K, Rademaker A, Bigio EH, Weintraub S, Rogalski E, Mesulam MM, Geula C. Morphometric and histologic substrates of cingulate integrity in elders with exceptional memory capacity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1781-91. PMID 25632151 DOI: 10.1523/Jneurosci.2998-14.2015  0.342
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Bigio EH, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.445
2015 SantaCruz KS, Rottunda SJ, Meints JP, Bearer EL, Bigio EH, McCarten JR. A case of globular glial tauopathy presenting clinically as alzheimer disease. Alzheimer Disease and Associated Disorders. 29: 82-4. PMID 23751368 DOI: 10.1097/Wad.0B013E318298E531  0.46
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.491
2014 Fawzi AA, Simonett JM, Purta P, Moss HE, Lowry JL, Deng HX, Siddique N, Sufit R, Bigio EH, Volpe NJ, Siddique T. Clinicopathologic report of ocular involvement in ALS patients with C9orf72 mutation. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 569-80. PMID 25319030 DOI: 10.3109/21678421.2014.951941  0.304
2014 Gorrie GH, Fecto F, Radzicki D, Weiss C, Shi Y, Dong H, Zhai H, Fu R, Liu E, Li S, Arrat H, Bigio EH, Disterhoft JF, Martina M, Mugnaini E, et al. Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2. Proceedings of the National Academy of Sciences of the United States of America. 111: 14524-9. PMID 25246588 DOI: 10.1073/Pnas.1405741111  0.384
2014 van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, et al. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Molecular Neurodegeneration. 9: 38. PMID 25239657 DOI: 10.1186/1750-1326-9-38  0.388
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Bigio EH, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.372
2014 Mesulam MM, Rogalski EJ, Wieneke C, Hurley RS, Geula C, Bigio EH, Thompson CK, Weintraub S. Primary progressive aphasia and the evolving neurology of the language network. Nature Reviews. Neurology. 10: 554-69. PMID 25179257 DOI: 10.1038/Nrneurol.2014.159  0.373
2014 van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, et al. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiology of Aging. 35: 2421.e13-7. PMID 24866401 DOI: 10.1016/J.Neurobiolaging.2014.04.016  0.379
2014 Bit-Ivan EN, Lee KH, Gitelman D, Weintraub S, Mesulam M, Rademakers R, Isaacs AM, Hatanpaa KJ, White CL, Mao Q, Akman O, DiMauro S, Bigio EH. Adult polyglucosan body disease with GBE1 haploinsufficiency and concomitant frontotemporal lobar degeneration. Neuropathology and Applied Neurobiology. 40: 778-82. PMID 24750115 DOI: 10.1111/Nan.12144  0.58
2014 Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. Journal of Neuropathology and Experimental Neurology. 73: 467-73. PMID 24709683 DOI: 10.1097/Nen.0000000000000070  0.404
2014 Mesulam MM, Weintraub S, Rogalski EJ, Wieneke C, Geula C, Bigio EH. Asymmetry and heterogeneity of Alzheimer's and frontotemporal pathology in primary progressive aphasia. Brain : a Journal of Neurology. 137: 1176-92. PMID 24574501 DOI: 10.1093/Brain/Awu024  0.502
2014 Riascos D, Nicholas A, Samaeekia R, Yukhananov R, Mesulam MM, Bigio EH, Weintraub S, Guo L, Geula C. Alterations of Ca²⁺-responsive proteins within cholinergic neurons in aging and Alzheimer's disease. Neurobiology of Aging. 35: 1325-33. PMID 24461366 DOI: 10.1016/J.Neurobiolaging.2013.12.017  0.408
2014 van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, ... Bigio EH, et al. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathologica. 127: 397-406. PMID 24385136 DOI: 10.1007/S00401-013-1240-4  0.368
2014 Gefen T, Papastefan S, Peterson M, Kım G, Rogalskı E, Weıntraub S, Bıgıo E, Mesulam M, Geula C. Histopathologic Substrates of Cingulate Integrity in SuperAging: A Stereological Study Neurobiology of Aging. 35: 718. DOI: 10.1016/J.Neurobiolaging.2013.10.048  0.376
2013 van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, ... ... Bigio EH, et al. C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology. 81: 1332-41. PMID 24027057 DOI: 10.1212/Wnl.0B013E3182A8250C  0.343
2013 Ahmed Z, Bigio EH, Budka H, Dickson DW, Ferrer I, Ghetti B, Giaccone G, Hatanpaa KJ, Holton JL, Josephs KA, Powers J, Spina S, Takahashi H, White CL, Revesz T, et al. Globular glial tauopathies (GGT): consensus recommendations. Acta Neuropathologica. 126: 537-44. PMID 23995422 DOI: 10.1007/S00401-013-1171-0  0.447
2013 Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL, Caselli R, et al. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Molecular Neurodegeneration. 8: 19. PMID 23800361 DOI: 10.1186/1750-1326-8-19  0.426
2013 Bigio EH. Making the diagnosis of frontotemporal lobar degeneration. Archives of Pathology & Laboratory Medicine. 137: 314-25. PMID 23451743 DOI: 10.5858/Arpa.2012-0075-Ra  0.496
2013 Bigio EH, Wu JY, Deng HX, Bit-Ivan EN, Mao Q, Ganti R, Peterson M, Siddique N, Geula C, Siddique T, Mesulam M. Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid. Acta Neuropathologica. 125: 463-5. PMID 23378033 DOI: 10.1007/S00401-013-1089-6  0.557
2013 Rogalski EJ, Gefen T, Shi J, Samimi M, Bigio E, Weintraub S, Geula C, Mesulam MM. Youthful memory capacity in old brains: anatomic and genetic clues from the Northwestern SuperAging Project. Journal of Cognitive Neuroscience. 25: 29-36. PMID 23198888 DOI: 10.1162/Jocn_A_00300  0.33
2013 Lee KH, Lall RR, Chandler JP, Bigio EH, Mao Q. Pineal chordoid meningioma complicated by repetitive hemorrhage during pregnancy: case report and literature review. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 33: 192-8. PMID 22784446 DOI: 10.1111/J.1440-1789.2012.01337.X  0.473
2013 Bigio EH, Weintraub S, Rademakers R, Baker M, Ahmadian SS, Rademaker A, Weitner BB, Mao Q, Lee KH, Mishra M, Ganti RA, Mesulam MM. Frontotemporal lobar degeneration with TDP-43 proteinopathy and chromosome 9p repeat expansion in C9ORF72: clinicopathologic correlation. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 33: 122-33. PMID 22702520 DOI: 10.1111/J.1440-1789.2012.01332.X  0.576
2012 Halliday G, Bigio EH, Cairns NJ, Neumann M, Mackenzie IR, Mann DM. Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effects. Acta Neuropathologica. 124: 373-82. PMID 22878865 DOI: 10.1007/S00401-012-1030-4  0.405
2012 Rutherford NJ, Heckman MG, Dejesus-Hernandez M, Baker MC, Soto-Ortolaza AI, Rayaprolu S, Stewart H, Finger E, Volkening K, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, et al. Length of normal alleles of C9ORF72 GGGGCC repeat do not influence disease phenotype. Neurobiology of Aging. 33: 2950.e5-7. PMID 22840558 DOI: 10.1016/J.Neurobiolaging.2012.07.005  0.376
2012 Keswani A, Bigio E, Grimm S. Lymphomatosis cerebri presenting with orthostatic hypotension, anorexia, and paraparesis. Journal of Neuro-Oncology. 109: 581-6. PMID 22806340 DOI: 10.1007/S11060-012-0931-3  0.358
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Bigio EH, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.451
2012 Gefen T, Gasho K, Rademaker A, Lalehzari M, Weintraub S, Rogalski E, Wieneke C, Bigio E, Geula C, Mesulam MM. Clinically concordant variations of Alzheimer pathology in aphasic versus amnestic dementia. Brain : a Journal of Neurology. 135: 1554-65. PMID 22522938 DOI: 10.1093/Brain/Aws076  0.515
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.439
2012 Bigio EH. Motor neuron disease: the C9orf72 hexanucleotide repeat expansion in FTD and ALS. Nature Reviews. Neurology. 8: 249-50. PMID 22487746 DOI: 10.1038/Nrneurol.2012.58  0.411
2012 Nakamura K, Greenwood A, Binder L, Bigio EH, Denial S, Nicholson L, Zhou XZ, Lu KP. Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease. Cell. 149: 232-44. PMID 22464332 DOI: 10.1016/J.Cell.2012.02.016  0.388
2012 Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 1-13. PMID 22265587 DOI: 10.1016/J.Jalz.2011.10.007  0.472
2012 Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathologica. 123: 1-11. PMID 22101365 DOI: 10.1007/S00401-011-0910-3  0.459
2012 Fecto F, Deng H, Chen W, Hong S, Boycott K, Gorrie G, Siddique N, Yang Y, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen G, Donkervoort S, ... Bigio E, et al. UBQLN2 Mutations in ALS and ALS/Dementia: A Genetic, Functional and Histopathological Analysis (S05.006) Neurology. 78: S05.006-S05.006. DOI: 10.1212/Wnl.78.1_Meetingabstracts.S05.006  0.327
2011 Bigio EH. C9ORF72, the new gene on the block, causes C9FTD/ALS: new insights provided by neuropathology. Acta Neuropathologica. 122: 653-5. PMID 22101324 DOI: 10.1007/S00401-011-0919-7  0.387
2011 Deng HX, Chen W, Hong ST, Boycott KM, Gorrie GH, Siddique N, Yang Y, Fecto F, Shi Y, Zhai H, Jiang H, Hirano M, Rampersaud E, Jansen GH, Donkervoort S, ... Bigio EH, et al. Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia. Nature. 477: 211-5. PMID 21857683 DOI: 10.1038/Nature10353  0.351
2011 Deng HX, Bigio EH, Zhai H, Fecto F, Ajroud K, Shi Y, Yan J, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T. Differential involvement of optineurin in amyotrophic lateral sclerosis with or without SOD1 mutations. Archives of Neurology. 68: 1057-61. PMID 21825243 DOI: 10.1001/Archneurol.2011.178  0.304
2011 Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IR, Perry RH, Skullerud K, Yokoo H, Cairns NJ. Spatial patterns of FUS-immunoreactive neuronal cytoplasmic inclusions (NCI) in neuronal intermediate filament inclusion disease (NIFID). Journal of Neural Transmission (Vienna, Austria : 1996). 118: 1651-7. PMID 21792670 DOI: 10.1007/S00702-011-0690-X  0.337
2011 Chen Y, Yang M, Deng J, Chen X, Ye Y, Zhu L, Liu J, Ye H, Shen Y, Li Y, Rao EJ, Fushimi K, Zhou X, Bigio EH, Mesulam M, et al. Expression of human FUS protein in Drosophila leads to progressive neurodegeneration. Protein & Cell. 2: 477-86. PMID 21748598 DOI: 10.1007/S13238-011-1065-7  0.357
2011 Guo W, Chen Y, Zhou X, Kar A, Ray P, Chen X, Rao EJ, Yang M, Ye H, Zhu L, Liu J, Xu M, Yang Y, Wang C, Zhang D, ... Bigio EH, et al. An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity. Nature Structural & Molecular Biology. 18: 822-30. PMID 21666678 DOI: 10.1038/Nsmb.2053  0.354
2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, et al. Ataxin-2 repeat-length variation and neurodegeneration. Human Molecular Genetics. 20: 3207-12. PMID 21610160 DOI: 10.1093/Hmg/Ddr227  0.383
2011 Bigio EH. TDP-43 variants of frontotemporal lobar degeneration. Journal of Molecular Neuroscience : Mn. 45: 390-401. PMID 21607722 DOI: 10.1007/S12031-011-9545-Z  0.371
2011 Page T, Gitcho MA, Mosaheb S, Carter D, Chakraverty S, Perry RH, Bigio EH, Gearing M, Ferrer I, Goate AM, Cairns NJ, Thorpe JR. FUS immunogold labeling TEM analysis of the neuronal cytoplasmic inclusions of neuronal intermediate filament inclusion disease: a frontotemporal lobar degeneration with FUS proteinopathy. Journal of Molecular Neuroscience : Mn. 45: 409-21. PMID 21603978 DOI: 10.1007/S12031-011-9549-8  0.343
2011 Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, ... ... Bigio E, et al. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of Neurology. 68: 488-97. PMID 21482928 DOI: 10.1001/Archneurol.2011.53  0.324
2011 Ferreira A, Bigio EH. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Molecular Medicine (Cambridge, Mass.). 17: 676-85. PMID 21442128 DOI: 10.2119/Molmed.2010.00220  0.432
2011 Rogalski EJ, Rademaker A, Harrison TM, Helenowski I, Johnson N, Bigio E, Mishra M, Weintraub S, Mesulam MM. ApoE E4 is a susceptibility factor in amnestic but not aphasic dementias. Alzheimer Disease and Associated Disorders. 25: 159-63. PMID 21346518 DOI: 10.1097/Wad.0B013E318201F249  0.465
2011 Dakson A, Yokota O, Esiri M, Bigio EH, Horan M, Pendleton N, Richardson A, Neary D, Snowden JS, Robinson A, Davidson YS, Mann DM. Granular expression of prolyl-peptidyl isomerase PIN1 is a constant and specific feature of Alzheimer's disease pathology and is independent of tau, Aβ and TDP-43 pathology. Acta Neuropathologica. 121: 635-49. PMID 21243369 DOI: 10.1007/S00401-011-0798-Y  0.498
2011 Armstrong RA, Gearing M, Bigio EH, Cruz-Sanchez FF, Duyckaerts C, Mackenzie IR, Perry RH, Skullerud K, Yokoo H, Cairns NJ. The spectrum and severity of FUS-immunoreactive inclusions in the frontal and temporal lobes of ten cases of neuronal intermediate filament inclusion disease. Acta Neuropathologica. 121: 219-28. PMID 20886222 DOI: 10.1007/S00401-010-0753-3  0.395
2011 Dequen F, Cairns NJ, Bigio EH, Julien JP. Gigaxonin mutation analysis in patients with NIFID. Neurobiology of Aging. 32: 1528-9. PMID 19782434 DOI: 10.1016/J.Neurobiolaging.2009.08.018  0.391
2010 Deng HX, Zhai H, Bigio EH, Yan J, Fecto F, Ajroud K, Mishra M, Ajroud-Driss S, Heller S, Sufit R, Siddique N, Mugnaini E, Siddique T. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Annals of Neurology. 67: 739-48. PMID 20517935 DOI: 10.1002/Ana.22051  0.358
2010 Yokota O, Davidson Y, Bigio EH, Ishizu H, Terada S, Arai T, Hasegawa M, Akiyama H, Sikkink S, Pickering-Brown S, Mann DM. Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy. Acta Neuropathologica. 120: 55-66. PMID 20512649 DOI: 10.1007/S00401-010-0702-1  0.432
2010 Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, ... ... Bigio EH, et al. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathologica. 120: 33-41. PMID 20490813 DOI: 10.1007/S00401-010-0698-6  0.442
2010 Gliebus G, Bigio EH, Gasho K, Mishra M, Caplan D, Mesulam MM, Geula C. Asymmetric TDP-43 distribution in primary progressive aphasia with progranulin mutation. Neurology. 74: 1607-10. PMID 20479359 DOI: 10.1212/Wnl.0B013E3181Df0A1B  0.429
2010 Perry A, Burton SS, Fuller GN, Robinson CA, Palmer CA, Resch L, Bigio EH, Gujrati M, Rosenblum MK. Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall. Acta Neuropathologica. 120: 237-52. PMID 20464403 DOI: 10.1007/S00401-010-0695-9  0.349
2010 Bigio EH, Mishra M, Hatanpaa KJ, White CL, Johnson N, Rademaker A, Weitner BB, Deng HX, Dubner SD, Weintraub S, Mesulam M. TDP-43 pathology in primary progressive aphasia and frontotemporal dementia with pathologic Alzheimer disease. Acta Neuropathologica. 120: 43-54. PMID 20361198 DOI: 10.1007/S00401-010-0681-2  0.79
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Bigio EH, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/Ng.536  0.328
2010 Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, et al. Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathologica. 119: 1-4. PMID 19924424 DOI: 10.1007/S00401-009-0612-2  0.36
2010 Chauhan NB, Bigio EH, Geula C, Gatto R. P4-033: Is Diabetes the Pre-disposing Co-morbid Trigger for Sporadic Alzheimer's Disease Alzheimer's & Dementia. 6: e30-e30. DOI: 10.1016/J.Jalz.2010.08.093  0.324
2009 Foulds PG, Davidson Y, Mishra M, Hobson DJ, Humphreys KM, Taylor M, Johnson N, Weintraub S, Akiyama H, Arai T, Hasegawa M, Bigio EH, Benson FE, Allsop D, Mann DM. Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration. Acta Neuropathologica. 118: 647-58. PMID 19823856 DOI: 10.1007/S00401-009-0594-0  0.397
2009 Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathologica. 118: 633-45. PMID 19618195 DOI: 10.1007/S00401-009-0571-7  0.368
2009 Mackenzie IR, Neumann M, Bigio EH, Cairns NJ, Alafuzoff I, Kril J, Kovacs GG, Ghetti B, Halliday G, Holm IE, Ince PG, Kamphorst W, Revesz T, Rozemuller AJ, Kumar-Singh S, et al. Nomenclature for neuropathologic subtypes of frontotemporal lobar degeneration: consensus recommendations. Acta Neuropathologica. 117: 15-8. PMID 19015862 DOI: 10.1007/S00401-008-0460-5  0.353
2008 Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of Neurology. 65: 1368-74. PMID 18852354 DOI: 10.1001/Archneur.65.10.1368  0.489
2008 Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/Journal.Pgen.1000193  0.335
2008 Bigio EH. Update on recent molecular and genetic advances in frontotemporal lobar degeneration. Journal of Neuropathology and Experimental Neurology. 67: 635-48. PMID 18596549 DOI: 10.1097/Nen.0B013E31817D751C  0.304
2008 Bigio EH. TAR DNA-binding protein-43 in amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer disease. Acta Neuropathologica. 116: 135-40. PMID 18575875 DOI: 10.1007/S00401-008-0405-Z  0.359
2008 Mesulam M, Wicklund A, Johnson N, Rogalski E, Léger GC, Rademaker A, Weintraub S, Bigio EH. Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Annals of Neurology. 63: 709-19. PMID 18412267 DOI: 10.1002/Ana.21388  0.481
2008 Hatanpaa KJ, Bigio EH, Cairns NJ, Womack KB, Weintraub S, Morris JC, Foong C, Xiao G, Hladik C, Mantanona TY, White CL. TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study. Journal of Neuropathology and Experimental Neurology. 67: 271-9. PMID 18379440 DOI: 10.1097/Nen.0B013E31816A12A6  0.446
2008 Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, et al. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 63: 535-8. PMID 18288693 DOI: 10.1002/Ana.21344  0.346
2008 Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Human Mutation. 29: 512-21. PMID 18183624 DOI: 10.1002/Humu.20681  0.417
2008 De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of Aging. 29: 1334-47. PMID 17403556 DOI: 10.1016/J.Neurobiolaging.2007.02.029  0.419
2008 Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CH, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, et al. P3-287: TDP-43 A315T mutation in familial motor neuron disease Alzheimer's & Dementia. 4: T606-T607. DOI: 10.1016/J.Jalz.2008.05.1855  0.317
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/Ajpath.2007.070182  0.384
2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathologica. 114: 5-22. PMID 17579875 DOI: 10.1007/S00401-007-0237-2  0.456
2007 Mishra M, Paunesku T, Woloschak GE, Siddique T, Zhu LJ, Lin S, Greco K, Bigio EH. Gene expression analysis of frontotemporal lobar degeneration of the motor neuron disease type with ubiquitinated inclusions. Acta Neuropathologica. 114: 81-94. PMID 17569064 DOI: 10.1007/S00401-007-0240-7  0.313
2007 Davion S, Johnson N, Weintraub S, Mesulam MM, Engberg A, Mishra M, Baker M, Adamson J, Hutton M, Rademakers R, Bigio EH. Clinicopathologic correlation in PGRN mutations. Neurology. 69: 1113-21. PMID 17522386 DOI: 10.1212/01.Wnl.0000267701.58488.69  0.383
2007 Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Annals of Neurology. 61: 427-34. PMID 17469116 DOI: 10.1002/Ana.21147  0.366
2007 Guillozet-Bongaarts AL, Glajch KE, Libson EG, Cahill ME, Bigio E, Berry RW, Binder LI. Phosphorylation and cleavage of tau in non-AD tauopathies. Acta Neuropathologica. 113: 513-20. PMID 17357802 DOI: 10.1007/S00401-007-0209-6  0.472
2007 Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/J.1471-4159.2006.04157.X  0.383
2007 Grudzien A, Shaw P, Weintraub S, Bigio E, Mash DC, Mesulam MM. Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease. Neurobiology of Aging. 28: 327-35. PMID 16574280 DOI: 10.1016/J.Neurobiolaging.2006.02.007  0.449
2007 Bigio EH, Mishra M, Johnson N, Mao H, Mesulam M. Characterization of TDP43 protein in primary progressive aphasia (PPA) and frontotemporal dementia (FTD) with Alzheimer disease (AD) pathology Journal of Neuropathology and Experimental Neurology. 66: 421. DOI: 10.1097/01.Jnen.0000268988.44653.7F  0.479
2007 Hatanpaa KJ, Bigio EH, Cairns NJ, Schneider JA, Foong C, Hladik C, Shang P, White CL. TDP-43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a Midwest-Southwest Consortium for FTLD study Journal of Neuropathology and Experimental Neurology. 66: 425. DOI: 10.1096/Fasebj.21.5.A24-C  0.378
2007 Bigio EH, Engberg A, Mishra M, Johnson N, Mesulam M. Basophilic inclusion body disease with novel ubiquitinated extracellular, cytoplasmic, and intranuclear inclusions Journal of Neuropathology and Experimental Neurology. 66: 423. DOI: 10.1096/Fasebj.21.5.A23-B  0.317
2006 Reynolds MR, Reyes JF, Fu Y, Bigio EH, Guillozet-Bongaarts AL, Berry RW, Binder LI. Tau nitration occurs at tyrosine 29 in the fibrillar lesions of Alzheimer's disease and other tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10636-45. PMID 17050703 DOI: 10.1523/Jneurosci.2143-06.2006  0.446
2006 Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, ... ... Bigio E, et al. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Human Molecular Genetics. 15: 2988-3001. PMID 16950801 DOI: 10.1093/Hmg/Ddl241  0.33
2006 Shiarli AM, Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio EH, Ghetti B, Murrell JR, Delisle MB, Mirra S, Crain B, Zolo P, Arima K, Iseki E, et al. Comparison of extent of tau pathology in patients with frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17), frontotemporal lobar degeneration with Pick bodies and early onset Alzheimer's disease. Neuropathology and Applied Neurobiology. 32: 374-87. PMID 16866983 DOI: 10.1111/J.1365-2990.2006.00736.X  0.453
2006 Bonte FJ, Harris TS, Hynan LS, Bigio EH, White CL. Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation. Clinical Nuclear Medicine. 31: 376-8. PMID 16785801 DOI: 10.1097/01.Rlu.0000222736.81365.63  0.32
2006 Deng HX, Shi Y, Furukawa Y, Zhai H, Fu R, Liu E, Gorrie GH, Khan MS, Hung WY, Bigio EH, Lukas T, Dal Canto MC, O'Halloran TV, Siddique T. Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 103: 7142-7. PMID 16636275 DOI: 10.1073/Pnas.0602046103  0.304
2006 de Silva R, Lashley T, Strand C, Shiarli AM, Shi J, Tian J, Bailey KL, Davies P, Bigio EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, et al. An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathologica. 111: 329-40. PMID 16552612 DOI: 10.1007/S00401-006-0048-X  0.415
2006 Momeni P, Cairns NJ, Perry RH, Bigio EH, Gearing M, Singleton AB, Hardy J. Mutation analysis of patients with neuronal intermediate filament inclusion disease (NIFID). Neurobiology of Aging. 27: 778.e1-778.e6. PMID 16005115 DOI: 10.1016/J.Neurobiolaging.2005.03.030  0.42
2006 Yan J, Siddique N, Slifer S, Bigio E, Mao H, Chen W, Liu E, Shi Y, Khan S, Haines J, Pericak-Vance M, Siddique T. A Major Novel Locus for ALS/FTD on Chromosome 9p21 and its Pathological Correlates: S61.006 Neurology. 67: 186-186. DOI: 10.1212/01.Wnl.0000234887.27166.69  0.432
2006 Weintraub S, Teylan M, Rader B, Bollenbeck M, Kukull WA, Rogalski EJ, Bigio EH, Mesulam M. P4-332: APOE4 IS NOT A RISK FACTOR FOR ALZHEIMER'S DISEASE PATHOLOGY IN PPA, IRRESPECTIVE OF CLINICAL SUBTYPE Alzheimer's & Dementia. 14: P1593-P1593. DOI: 10.1016/J.Jalz.2018.07.155  0.394
2006 Ohm DT, Kim G, Gefen T, Rademaker A, Weintraub S, Bigio EH, Mesulam M, Rogalski EJ, Geula C. P2-169: NEUROFIBRILLARY TANGLES PREDICT IN VIVO CORTICAL ATROPHY IN PRIMARY PROGRESSIVE APHASIA WITH ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P733-P733. DOI: 10.1016/J.Jalz.2018.06.856  0.402
2006 Dunlop SR, Lalehzari N, Ohm DT, Kim G, Weintraub S, Bigio EH, Mesulam M, Geula C. P3-460: VULNERABILITY OF THE CHOLINERGIC BASAL FOREBRAIN TO AD VERSUS FTLD-TDP PATHOLOGY IN PRIMARY PROGRESSIVE APHASIA Alzheimer's & Dementia. 14: P1295-P1295. DOI: 10.1016/J.Jalz.2018.06.1824  0.414
2005 Mosaheb S, Thorpe JR, Hashemzadeh-Bonehi L, Bigio EH, Gearing M, Cairns NJ. Neuronal intranuclear inclusions are ultrastructurally and immunologically distinct from cytoplasmic inclusions of neuronal intermediate filament inclusion disease. Acta Neuropathologica. 110: 360-8. PMID 16025283 DOI: 10.1007/S00401-005-1057-X  0.365
2005 Guillozet-Bongaarts AL, Garcia-Sierra F, Reynolds MR, Horowitz PM, Fu Y, Wang T, Cahill ME, Bigio EH, Berry RW, Binder LI. Tau truncation during neurofibrillary tangle evolution in Alzheimer's disease. Neurobiology of Aging. 26: 1015-22. PMID 15748781 DOI: 10.1016/J.Neurobiolaging.2004.09.019  0.426
2004 Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/Jneurosci.3432-04.2004  0.403
2004 Cairns NJ, Grossman M, Arnold SE, Burn DJ, Jaros E, Perry RH, Duyckaerts C, Stankoff B, Pillon B, Skullerud K, Cruz-Sanchez FF, Bigio EH, Mackenzie IR, Gearing M, Juncos JL, et al. Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology. 63: 1376-84. PMID 15505152 DOI: 10.1212/01.Wnl.0000139809.16817.Dd  0.33
2004 Berry RW, Sweet AP, Clark FA, Lagalwar S, Lapin BR, Wang T, Topgi S, Guillozet-Bongaarts AL, Cochran EJ, Bigio EH, Binder LI. Tau epitope display in progressive supranuclear palsy and corticobasal degeneration. Journal of Neurocytology. 33: 287-95. PMID 15475684 DOI: 10.1023/B:Neur.0000044190.96426.B9  0.468
2004 Lipton AM, White CL, Bigio EH. Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration. Acta Neuropathologica. 108: 379-85. PMID 15351890 DOI: 10.1007/S00401-004-0900-9  0.446
2004 Bigio EH, Johnson NA, Rademaker AW, Fung BB, Mesulam MM, Siddique N, Dellefave L, Caliendo J, Freeman S, Siddique T. Neuronal ubiquitinated intranuclear inclusions in familial and non-familial frontotemporal dementia of the motor neuron disease type associated with amyotrophic lateral sclerosis. Journal of Neuropathology and Experimental Neurology. 63: 801-11. PMID 15330335 DOI: 10.1093/Jnen/63.8.801  0.391
2004 Hatanpaa KJ, Blass DM, Pletnikova O, Crain BJ, Bigio EH, Hedreen JC, White CL, Troncoso JC. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology. 63: 538-42. PMID 15304590 DOI: 10.1212/01.Wnl.0000129543.46734.C0  0.487
2004 Lipton AM, Benavides R, Hynan LS, Bonte FJ, Harris TS, White CL, Bigio EH. Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 17: 324-7. PMID 15178946 DOI: 10.1159/000077164  0.415
2004 Cairns NJ, Uryu K, Bigio EH, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Arnold SE, Lee VM, Trojanowski JQ. alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathologica. 108: 213-23. PMID 15170578 DOI: 10.1007/S00401-004-0882-7  0.384
2004 Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM, Trojanowski JQ. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. The American Journal of Pathology. 164: 2153-61. PMID 15161649 DOI: 10.1016/S0002-9440(10)63773-X  0.419
2003 Weiner MF, Hynan LS, Parikh B, Zaki N, White CL, Bigio EH, Lipton AM, Martin-Cook K, Svetlik DA, Cullum CM, Vobach S, Rosenberg RN. Can alzheimer's disease and dementias with Lewy bodies be distinguished clinically? Journal of Geriatric Psychiatry and Neurology. 16: 245-50. PMID 14653435 DOI: 10.1177/0891988703258671  0.455
2003 Hogg M, Grujic ZM, Baker M, Demirci S, Guillozet AL, Sweet AP, Herzog LL, Weintraub S, Mesulam MM, LaPointe NE, Gamblin TC, Berry RW, Binder LI, de Silva R, Lees A, ... ... Bigio EH, et al. The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy. Acta Neuropathologica. 106: 323-36. PMID 12883828 DOI: 10.1007/S00401-003-0734-X  0.384
2003 Bigio EH, Reisch JS, White CL, Satumtira S, Sontag E, Bonte FJ. Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease. Dementia and Geriatric Cognitive Disorders. 15: 72-8. PMID 12566595 DOI: 10.1159/000067970  0.378
2002 Morris HR, Baker M, Yasojima K, Houlden H, Khan MN, Wood NW, Hardy J, Grossman M, Trojanowski J, Revesz T, Bigio EH, Bergeron C, Janssen JC, McGeer PL, Rossor MN, et al. Analysis of tau haplotypes in Pick's disease. Neurology. 59: 443-5. PMID 12177383 DOI: 10.1212/Wnl.59.3.443  0.417
2002 Bigio EH, Hynan LS, Sontag E, Satumtira S, White CL. Synapse loss is greater in presenile than senile onset Alzheimer disease: implications for the cognitive reserve hypothesis. Neuropathology and Applied Neurobiology. 28: 218-27. PMID 12060346 DOI: 10.1046/J.1365-2990.2002.00385.X  0.478
2001 Lipton AM, Cullum CM, Satumtira S, Sontag E, Hynan LS, White CL, Bigio EH. Contribution of asymmetric synapse loss to lateralizing clinical deficits in frontotemporal dementias. Archives of Neurology. 58: 1233-9. PMID 11493163 DOI: 10.1001/Archneur.58.8.1233  0.435
2001 Houlden H, Baker M, Morris HR, MacDonald N, Pickering-Brown S, Adamson J, Lees AJ, Rossor MN, Quinn NP, Kertesz A, Khan MN, Hardy J, Lantos PL, St George-Hyslop P, Munoz DG, ... ... Bigio EH, et al. Corticobasal degeneration and progressive supranuclear palsy share a common tau haplotype. Neurology. 56: 1702-6. PMID 11425937 DOI: 10.1212/Wnl.56.12.1702  0.412
2001 Bigio EH, Vono MB, Satumtira S, Adamson J, Sontag E, Hynan LS, White CL, Baker M, Hutton M. Cortical synapse loss in progressive supranuclear palsy. Journal of Neuropathology and Experimental Neurology. 60: 403-10. PMID 11379815 DOI: 10.1093/Jnen/60.5.403  0.759
2001 Bigio EH, Lipton AM, Yen SH, Hutton ML, Baker M, Nacharaju P, White CL, Davies P, Lin W, Dickson DW. Frontal lobe dementia with novel tauopathy: sporadic multiple system tauopathy with dementia. Journal of Neuropathology and Experimental Neurology. 60: 328-41. PMID 11305868 DOI: 10.1093/Jnen/60.4.328  0.465
2000 Honig LS, Chambliss DD, Bigio EH, Carroll SL, Elliott JL. Glutamate transporter EAAT2 splice variants occur not only in ALS, but also in AD and controls. Neurology. 55: 1082-8. PMID 11071482 DOI: 10.1212/Wnl.55.8.1082  0.35
1999 Bigio EH, Colvin SM, Mickey BE, White CL, Rushing EJ. Radiation change versus recurrent astrocytoma: diagnostic utility of the proliferation index? Journal of Neuro-Oncology. 41: 55-63. PMID 10222423 DOI: 10.1023/A:1006112228001  0.699
1999 Bigio EH, Brown DF, White CL. Progressive supranuclear palsy with dementia: cortical pathology. Journal of Neuropathology and Experimental Neurology. 58: 359-64. PMID 10218631 DOI: 10.1097/00005072-199904000-00006  0.601
1998 Brown DF, Risser RC, Bigio EH, Tripp P, Stiegler A, Welch E, Eagan KP, Hladik CL, White CL. Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging. Journal of Neuropathology and Experimental Neurology. 57: 955-60. PMID 9786245 DOI: 10.1097/00005072-199810000-00007  0.621
1998 Brown DF, Dababo MA, Bigio EH, Risser RC, Eagan KP, Hladik CL, White CL. Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease. Journal of Neuropathology and Experimental Neurology. 57: 39-46. PMID 9600196 DOI: 10.1097/00005072-199801000-00006  0.79
1998 Bigio EH, Fontaine CS, Dababo MA, Prahlow JA, Chason DP, Weiner MF, White CL. Dementia associated with cortical dysplasia. Acta Neuropathologica. 95: 193-8. PMID 9498056 DOI: 10.1007/S004010050786  0.737
1998 Brown PF, Risser RC, Bigio EH, Hladik CL, White CL. LEWY BODY DENSITY DOES NOT CORRELATE WITH NEOCORTICAL SYNAPSE DENSITY IN THE LEWY BODY VARIANT OF ALZHEIMER DISEASE Journal of Neuropathology and Experimental Neurology. 57: 515. DOI: 10.1097/00005072-199805000-00202  0.329
1997 Bonte FJ, Weiner MF, Bigio EH, White CL. Brain blood flow in the dementias: SPECT with histopathologic correlation in 54 patients. Radiology. 202: 793-7. PMID 9051035 DOI: 10.1148/Radiology.202.3.9051035  0.377
1995 Hladik CL, Dababo A, Bigio EH, White CL. AUTOMATED DOUBLE-LABEL IMMUNOHISTOCHEMISTRY USING ANTIBODIES TO TAU AND UBIQUITIN TO DISTINGUISH NEOCORTICAL LEWY BODIES FROM GLOBOSE NEUROFIBRILLARY TANGLES IN BRAINS FROM DEMENTED PATIENTS Journal of Neuropathology and Experimental Neurology. 54: 446. DOI: 10.1097/00005072-199505000-00156  0.336
1995 White CL, Trioo P, Eagan KP, Weich E, Stieqler A, Bigio EH. QUANTIFICATION OF SYNAPSE DENSITY IN ALZHEIMER DISEASE NEOCORTEX USING A TWO-SITE ENZYME-LINKED IMMUNOSORBANT ASSAY (ELISA) AND ANTIBODIES TO SYNAPTOPHYSIN Journal of Neuropathology and Experimental Neurology. 54: 430. DOI: 10.1097/00005072-199505000-00094  0.312
1993 Bonte FJ, Tintner R, Weiner MF, Bigio EH, White CL. Brain blood flow in the dementias: SPECT with histopathologic correlation. Radiology. 186: 361-5. PMID 8421735 DOI: 10.1148/Radiology.186.2.8421735  0.364
1990 Bigio EH, Sparkman DR, Clark AW, White CL. NEUROFIBRILLARY TANGLES PRECEDE AMYLOID PLAQUES IN DOWN SYNDROME Journal of Neuropathology and Experimental Neurology. 49: 265. DOI: 10.1097/00005072-199005000-00020  0.347
Low-probability matches (unlikely to be authored by this person)
2013 Pressman P, Bigio EH, Gitelman D, Zadikoff C. Clinical Reasoning: a woman with rapidly progressive apraxia. Neurology. 80: e162-5. PMID 23569002 DOI: 10.1212/Wnl.0B013E31828C2Eb8  0.3
2007 Mesulam M, Johnson N, Krefft TA, Gass JM, Cannon AD, Adamson JL, Bigio EH, Weintraub S, Dickson DW, Hutton ML, Graff-Radford NR. Progranulin mutations in primary progressive aphasia: the PPA1 and PPA3 families. Archives of Neurology. 64: 43-7. PMID 17210807 DOI: 10.1001/Archneur.64.1.43  0.299
2018 Ohm DT, Kim G, Gefen T, Rademaker A, Weintraub S, Bigio E, Mesulam MM, Rogalski E, Geula C. Prominent microglial activation in cortical white matter is selectively associated with cortical atrophy in primary progressive aphasia. Neuropathology and Applied Neurobiology. PMID 29679378 DOI: 10.1111/Nan.12494  0.299
1994 Bonte F, Tintner R, Weiner M, Bigio E, White C. HISTOPATHOLOGIC VALIDATION OF BRAIN BLOOD FLOW SPECT IN THE DIFFERENTIAL DIAGNOSIS OF THE DEMENTIAS Clinical Nuclear Medicine. 19: 260. DOI: 10.1097/00003072-199403000-00029  0.297
1991 Sparkman DR, Bigio EH, White CL. Neuropathologic examination of rabbit brain after long-term immunization with Alzheimer paired helical filaments. Alzheimer Disease and Associated Disorders. 5: 194-6. PMID 1772640 DOI: 10.1097/00002093-199100530-00006  0.297
1999 Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Perez-Tur J, Hardy J, Lynch T, Bigio E, Hutton M. Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Human Molecular Genetics. 8: 711-5. PMID 10072441 DOI: 10.1093/Hmg/8.4.711  0.296
2015 Deng J, Yang M, Chen Y, Chen X, Liu J, Sun S, Cheng H, Li Y, Bigio EH, Mesulam M, Xu Q, Du S, Fushimi K, Zhu L, Wu JY. FUS Interacts with HSP60 to Promote Mitochondrial Damage. Plos Genetics. 11: e1005357. PMID 26335776 DOI: 10.1371/Journal.Pgen.1005357  0.295
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Bigio EH, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.295
2007 Melquist S, Craig DW, Huentelman MJ, Crook R, Pearson JV, Baker M, Zismann VL, Gass J, Adamson J, Szelinger S, Corneveaux J, Cannon A, Coon KD, Lincoln S, Adler C, ... ... Bigio EH, et al. Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms. American Journal of Human Genetics. 80: 769-78. PMID 17357082 DOI: 10.1086/513320  0.295
2003 Bigio EH, Lipton AM, White CL, Dickson DW, Hirano A. Frontotemporal and motor neurone degeneration with neurofilament inclusion bodies: additional evidence for overlap between FTD and ALS. Neuropathology and Applied Neurobiology. 29: 239-53. PMID 12787321 DOI: 10.1046/J.1365-2990.2003.00466.X  0.294
2016 Lui H, Zhang J, Makinson SR, Cahill MK, Kelley KW, Huang HY, Shang Y, Oldham MC, Martens LH, Gao F, Coppola G, Sloan SA, Hsieh CL, Kim CC, Bigio EH, et al. Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation. Cell. PMID 27114033 DOI: 10.1016/J.Cell.2016.04.001  0.291
2014 Zhu L, Xu M, Yang M, Yang Y, Li Y, Deng J, Ruan L, Liu J, Du S, Liu X, Feng W, Fushimi K, Bigio EH, Mesulam M, Wang C, et al. An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution. Human Molecular Genetics. 23: 6863-77. PMID 25113748 DOI: 10.1093/Hmg/Ddu409  0.29
1997 Bigio EH, Weiner MF, Bonte FJ, White CL. Familial dementia due to adult polyglucosan body disease. Clinical Neuropathology. 16: 227-34. PMID 9266150  0.29
2020 Jamshidi P, Kim G, Shahidehpour RK, Bolbolan K, Gefen T, Bigio EH, Mesulam MM, Geula C. Distribution of TDP-43 Pathology in Hippocampal Synaptic Relays Suggests Transsynaptic Propagation in Frontotemporal Lobar Degeneration. Journal of Neuropathology and Experimental Neurology. PMID 32388566 DOI: 10.1093/Jnen/Nlaa029  0.289
2007 Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, ... ... Bigio EH, et al. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. The Lancet. Neurology. 6: 857-68. PMID 17826340 DOI: 10.1016/S1474-4422(07)70221-1  0.287
2018 Besser LM, Kukull WA, Teylan MA, Bigio EH, Cairns NJ, Kofler JK, Montine TJ, Schneider JA, Nelson PT. The Revised National Alzheimer's Coordinating Center's Neuropathology Form-Available Data and New Analyses. Journal of Neuropathology and Experimental Neurology. PMID 29945202 DOI: 10.1093/Jnen/Nly049  0.285
2004 Cairns NJ, Zhukareva V, Uryu K, Bigio E, Makenzie IR, Geaing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM, Trojanowski JQ. O4-06-01 α-Internexin is present in the hallmark lesions of neuronal intermediate filament inclusion disease Neurobiology of Aging. 25: S85. DOI: 10.1016/S0197-4580(04)80288-4  0.284
2013 Davidson YS, Robinson AC, Hu Q, Mishra M, Baborie A, Jaros E, Perry RH, Cairns NJ, Richardson A, Gerhard A, Neary D, Snowden JS, Bigio EH, Mann DM. Nuclear carrier and RNA-binding proteins in frontotemporal lobar degeneration associated with fused in sarcoma (FUS) pathological changes. Neuropathology and Applied Neurobiology. 39: 157-65. PMID 22497712 DOI: 10.1111/J.1365-2990.2012.01274.X  0.283
2015 Oboudiyat C, Bigio EH, Bonakdarpour B, Baker MC, Rademakers R, Weintraub S, Mesulam MM. Diffuse leukoencephalopathy with spheroids presenting as primary progressive aphasia. Neurology. 85: 652-3. PMID 26203093 DOI: 10.1212/Wnl.0000000000001851  0.283
2011 Deng HX, Bigio EH, Siddique T. Detection of protein aggregation in neurodegenerative diseases. Methods in Molecular Biology (Clifton, N.J.). 793: 259-72. PMID 21913106 DOI: 10.1007/978-1-61779-328-8_17  0.281
2010 Venkatasubramanian PN, Bigio EH, Pych JC, Weintraub S, Mesulam MM, Wyrwicz AM. Diffusion tensor imaging can differentiate human Alzheimer brain from normal brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1436  0.279
2016 Ohm DT, Kim G, Gefen T, Parton Z, Bigio EH, Rogalski EJ, Mesulam MM, Geula C. P4-227: High Densities of Activated Microglia are Present in Cortical White Matter and Correspond to Regions of Greatest Atrophy in Primary Progressive Aphasia Alzheimer's & Dementia. 12: P1116-P1116. DOI: 10.1016/J.Jalz.2016.06.2319  0.279
2022 Martersteck A, Ayala I, Ohm DT, Spencer C, Coventry C, Weintraub S, Bigio EH, Mesulam M-, Geula C, Rogalski E. Focal amyloid and asymmetric tau in an imaging-to-autopsy case of clinical primary progressive aphasia with Alzheimer disease neuropathology. Acta Neuropathologica Communications. 10: 111. PMID 35945628 DOI: 10.1186/s40478-022-01412-w  0.276
2011 Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, ... ... Bigio EH, et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology. 76: 467-74. PMID 21178100 DOI: 10.1212/Wnl.0B013E31820A0E3B  0.275
2021 Griswold AJ, Celis K, Bussies PL, Rajabli F, Whitehead PL, Hamilton-Nelson KL, Beecham GW, Dykxhoorn DM, Nuytemans K, Wang L, Gardner OK, Dorfsman DA, Bigio EH, Mesulam MM, Weintraub S, et al. Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33522086 DOI: 10.1002/alz.12287  0.273
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Bigio EH, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.272
1997 Rushing EJ, Barnard JJ, Bigio EH, Eagan KP, White CL. Frequency of unilateral and bilateral mesial temporal sclerosis in primary and secondary epilepsy: a forensic autopsy study. The American Journal of Forensic Medicine and Pathology. 18: 335-41. PMID 9430283 DOI: 10.1097/00000433-199712000-00004  0.272
2018 Gautam M, Jara JH, Kocak N, Rylaarsdam LE, Kim KD, Bigio EH, Hande Özdinler P. Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology. Acta Neuropathologica. PMID 30450515 DOI: 10.1007/S00401-018-1934-8  0.264
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Bigio EH, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.264
2021 Mesulam M-, Coventry C, Bigio EH, Geula C, Thompson C, Bonakdarpour B, Gefen T, Rogalski EJ, Weintraub S. Nosology of Primary Progressive Aphasia and the Neuropathology of Language. Advances in Experimental Medicine and Biology. 1281: 33-49. PMID 33433867 DOI: 10.1007/978-3-030-51140-1_3  0.261
2017 Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, ... ... Bigio E, et al. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Science Translational Medicine. 9. PMID 28404863 DOI: 10.1126/Scitranslmed.Aah5642  0.261
2000 Diaz-Arrastia R, Agostini MA, Frol AB, Mickey B, Fleckenstein J, Bigio E, Van Ness PC. Neurophysiologic and neuroradiologic features of intractable epilepsy after traumatic brain injury in adults. Archives of Neurology. 57: 1611-6. PMID 11074793 DOI: 10.1001/Archneur.57.11.1611  0.261
2022 Luo W, Pryzbyl KJ, Bigio EH, Weintraub S, Mesulam MM, Redei EE. Reduced Hippocampal and Anterior Cingulate Expression of Antioxidant Enzymes and Membrane Progesterone Receptors in Alzheimer's Disease with Depression. Journal of Alzheimer's Disease : Jad. PMID 35871353 DOI: 10.3233/JAD-220574  0.257
1994 Pardue S, White CL, Bigio EH, Morrison-Bogorad M. Anomalous binding of radiolabeled oligonucleotide probes to plaques and tangles in Alzheimer disease hippocampus. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 22: 1-24. PMID 7916765  0.256
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Bigio EH, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.256
2011 Ogiwara H, Dubner S, Bigio E, Chandler J. Neurocytoma of the cerebellum. Surgical Neurology International. 2: 36. PMID 21541206 DOI: 10.4103/2152-7806.78246  0.256
2015 Rogalski EJ, Gefen T, Cook A, Bigio EH, Weintraub S, Geula C, Mesulam M. S4-01-03: Neurobiologic features of cognitive superaging Alzheimer's & Dementia. 11: P257-P257. DOI: 10.1016/J.Jalz.2015.07.323  0.252
2017 Genç B, Jara JH, Lagrimas AK, Pytel P, Roos RP, Mesulam MM, Geula C, Bigio EH, Özdinler PH. Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Scientific Reports. 7: 41765. PMID 28165465 DOI: 10.1038/Srep41765  0.25
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Bigio EH, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.245
2003 Strong MJ, Lomen-Hoerth C, Caselli RJ, Bigio EH, Yang W. Cognitive impairment, frontotemporal dementia, and the motor neuron diseases. Annals of Neurology. 54: S20-3. PMID 12833364 DOI: 10.1002/Ana.10574  0.244
1998 Barnea A, Aguila-Mansilla N, Bigio EH, Worby C, Roberts J. Evidence for regulated expression of neuropeptide Y gene by rat and human cultured astrocytes. Regulatory Peptides. 75: 293-300. PMID 9802422 DOI: 10.1016/S0167-0115(98)00081-0  0.243
2018 Hirsch-Reinshagen V, Nicholson A, Pottier C, Baker M, Hsiung G, Krieger C, Boylan K, Weintraub S, Mesulam M, Bigio E, Zinman L, Keith J, Rogaeva E, Zivkovic S, Lacomis D, et al. Clinical and neuropathological features of ALS/FTD with TIA1 mutations Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 45: S5-S5. DOI: 10.1017/CJN.2018.48  0.239
2019 Mesulam MM, Lalehzari N, Rahmani F, Ohm D, Shahidehpour R, Kim G, Gefen T, Weintraub S, Bigio E, Geula C. Cortical cholinergic denervation in primary progressive aphasia with Alzheimer pathology. Neurology. PMID 30842294 DOI: 10.1212/Wnl.0000000000007247  0.235
2018 Huentelman MJ, Piras IS, Siniard AL, De Both MD, Richholt RF, Balak CD, Jamshidi P, Bigio EH, Weintraub S, Loyer ET, Mesulam MM, Geula C, Rogalski EJ. Associations of Gene Variants With Superior Memory in SuperAgers. Frontiers in Aging Neuroscience. 10: 155. PMID 29896098 DOI: 10.3389/Fnagi.2018.00155  0.235
2017 Huentelman MJ, Piras I, Siniard A, De Both M, Richholt R, Bigio EH, Weintraub S, Loyer E, Mesulam M, Geula C, Rogalski EJ. [P4-081]: ASSOCIATION OF MAP2K3 GENE VARIATION AND THE SUPERAGING PHENOTYPE DETECTED BY WHOLE EXOME SEQUENCING Alzheimer's & Dementia. 13: P1290-P1290. DOI: 10.1016/J.Jalz.2017.06.1946  0.235
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, ... ... Bigio E, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  0.229
2016 Kim G, Ahmadian SS, Peterson M, Parton Z, Memon R, Weintraub S, Rademaker A, Bigio E, Mesulam MM, Geula C. Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions. Neurology. PMID 26791154 DOI: 10.1212/Wnl.0000000000002375  0.218
2019 Gefen T, Kim G, Bolbolan K, Geoly A, Ohm D, Oboudiyat C, Shahidehpour R, Rademaker A, Weintraub S, Bigio EH, Mesulam MM, Rogalski E, Geula C. Activated Microglia in Cortical White Matter Across Cognitive Aging Trajectories. Frontiers in Aging Neuroscience. 11: 94. PMID 31139072 DOI: 10.3389/Fnagi.2019.00094  0.216
2014 Rogalski EJ, Rademaker A, Wieneke C, Bigio EH, Weintraub S, Mesulam MM. Association between the prevalence of learning disabilities and primary progressive aphasia. Jama Neurology. 71: 1576-7. PMID 25486208 DOI: 10.1001/Jamaneurol.2014.2805  0.216
2019 Kim G, Bolbolan K, Shahidehpour R, Jamshidi P, Gefen T, Ayala IA, Weintraub S, Bigio EH, Mesulam MM, Geula C. Morphology and Distribution of TDP-43 Pre-inclusions in Primary Progressive Aphasia. Journal of Neuropathology and Experimental Neurology. PMID 30753613 DOI: 10.1093/Jnen/Nlz005  0.214
2002 Oeberst JL, Barnard JJ, Bigio EH, Prahlow JA. Neurocysticercosis. The American Journal of Forensic Medicine and Pathology. 23: 31-5. PMID 11953490  0.208
2018 Kim G, Bolbolan K, Gefen T, Weintraub S, Bigio EH, Rogalski E, Mesulam MM, Geula C. Atrophy and microglial distribution in primary progressive aphasia with TDP-43. Annals of Neurology. PMID 29665116 DOI: 10.1002/Ana.25240  0.207
2023 Zouridakis A, Ayala I, Minogue G, Kawles A, Keszycki R, Macomber A, Bigio EH, Geula C, Mesulam MM, Gefen T. Shades of gray in human white matter. The Journal of Comparative Neurology. PMID 37376715 DOI: 10.1002/cne.25512  0.205
2019 Lu X, Sukhanova M, Gao J, Horbinski C, Jennings L, Mao Q, Bigio E, Brat D, Appin C. 4. Molecular characterizations of adult diffuse gliomas by the Oncoscan CNV Plus assay and next-generation sequencing (NGS) Cancer Genetics and Cytogenetics. DOI: 10.1016/J.Cancergen.2019.04.010  0.2
2004 Moore P, Dennis K, DeVita C, Grossman M, Lebert F, Stekke W, Hasenbroekx C, Pasquier F, Johnson JK, Vogt BA, Kim R, Cotman CW, Head E, Comstock H, Pickering-Brown S, ... ... Bigio EH, et al. Subject Index Vol. 17, 2004 Dementia and Geriatric Cognitive Disorders. 17: 384-385. DOI: 10.1159/000078836  0.197
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Bigio EH, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.194
2019 Josephs KA, Mackenzie I, Frosch MP, Bigio EH, Neumann M, Arai T, Dugger BN, Ghetti B, Grossman M, Hasegawa M, Herrup K, Holton J, Jellinger K, Lashley T, McAleese KE, et al. LATE to the PART-y. Brain : a Journal of Neurology. PMID 31359030 DOI: 10.1093/Brain/Awz224  0.191
1998 Rushing EJ, White JA, D' Alise MD, Chason DP, White CL, Bigio EH. Primary epithelioid hemangioendothelioma of the clivus. Clinical Neuropathology. 17: 110-4. PMID 9561333  0.189
2020 Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109  0.186
1993 White CL, Simmons AL, Bigio EH. DETERMINATION OF SYNAPSE DENSITY IN ALZHEIMER DISEASE NEOCORTEX USING AN ENZYME-LINKED IMMUNOSORBANT ASSAY (ELISA) AND MONOCLONAL ANTIBODY SY38 TO SYNAPTOPHYSIN Journal of Neuropathology and Experimental Neurology. 52: 263. DOI: 10.1097/00005072-199305000-00014  0.179
1998 Maldonado S, Gross JB, Bigio EH. Creutzfeldt-Jakob Disease Baylor University Medical Center Proceedings. 11: 89-98. DOI: 10.1080/08998280.1998.11930089  0.178
1998 Amato AA, Kagan-Hallet K, Jackson CE, Lampkin S, Wolfe GI, Ferrante M, Bigio EH, Barohn RJ. The wide spectrum of myofibrillar myopathy suggests a multifactorial etiology and pathogenesis. Neurology. 51: 1646-55. PMID 9855517  0.175
2004 Moore P, Dennis K, DeVita C, Grossman M, Lebert F, Stekke W, Hasenbroekx C, Pasquier F, Johnson JK, Vogt BA, Kim R, Cotman CW, Head E, Comstock H, Pickering-Brown S, ... ... Bigio EH, et al. Contents Vol. 17, 2004 Dementia and Geriatric Cognitive Disorders. 17: 387-389. DOI: 10.1159/000078837  0.174
2018 Dervishi I, Gozutok O, Murnan K, Gautam M, Heller D, Bigio E, Ozdinler PH. Protein-protein interactions reveal key canonical pathways, upstream regulators, interactome domains, and novel targets in ALS. Scientific Reports. 8: 14732. PMID 30283000 DOI: 10.1038/s41598-018-32902-4  0.172
2019 Mesulam MM, Nelson MJ, Hyun J, Rader B, Hurley RS, Rademakers R, Baker MC, Bigio EH, Weintraub S. Preferential Disruption of Auditory Word Representations in Primary Progressive Aphasia With the Neuropathology of FTLD-TDP Type A. Cognitive and Behavioral Neurology : Official Journal of the Society For Behavioral and Cognitive Neurology. 32: 46-53. PMID 30896577 DOI: 10.1097/Wnn.0000000000000180  0.167
2006 Cairns NJ, Bigio EH, Mackenzie IR. Letter to the editor. Journal of Neuropathology and Experimental Neurology. 65: 97; author reply 97-. PMID 16410754 DOI: 10.1097/01.Jnen.0000195944.32786.F7  0.158
2017 Janeczek M, Gefen T, Samimi M, Kim G, Weintraub S, Bigio E, Rogalski E, Mesulam MM, Geula C. Variations in Acetylcholinesterase Activity within Human Cortical Pyramidal Neurons Across Age and Cognitive Trajectories. Cerebral Cortex (New York, N.Y. : 1991). 1-9. PMID 28334147 DOI: 10.1093/Cercor/Bhx047  0.158
2001 Bonte FJ, Weiner MF, Bigio EH, White CL. SPECT imaging in dementias. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 42: 1131-3. PMID 11438640  0.158
2010 Venkatasubramanian PN, Bigio EH, Pych JC, Weintraub S, Mesulam M-, Wyrwicz AM. IC-P-096: Diffusion Tensor Imaging can Differentiate Human AD Brain from Normal Brain Alzheimer's & Dementia. 6: S39-S39. DOI: 10.1016/j.jalz.2010.05.110  0.157
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/J.Neuron.2016.05.021  0.154
2017 Li W, Reeb AN, Lin B, Subramanian P, Fey EE, Knoverek CR, French RL, Bigio EH, Ayala YM. Heat Shock Induced Phosphorylation of TAR DNA Binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function. The Journal of Biological Chemistry. PMID 28167528 DOI: 10.1074/jbc.M116.753913  0.148
2018 Kim G, Vahedi S, Gefen T, Weintraub S, Bigio EH, Mesulam MM, Geula C. Asymmetric TDP pathology in primary progressive aphasia with right hemisphere language dominance. Neurology. PMID 29305438 DOI: 10.1212/Wnl.0000000000004891  0.135
2018 Mesulam MM, Rader BM, Sridhar J, Nelson MJ, Hyun J, Rademaker A, Geula C, Bigio EH, Thompson CK, Gefen TD, Weintraub S, Rogalski EJ. Word comprehension in temporal cortex and Wernicke area: A PPA perspective. Neurology. PMID 30578374 DOI: 10.1212/Wnl.0000000000006788  0.132
2017 Jara JH, Genç B, Stanford MJ, Pytel P, Roos RP, Weintraub S, Mesulam MM, Bigio EH, Miller RJ, Özdinler PH. Evidence for an early innate immune response in the motor cortex of ALS. Journal of Neuroinflammation. 14: 129. PMID 28651542 DOI: 10.1186/S12974-017-0896-4  0.109
2019 Wang P, Deng J, Dong J, Liu J, Bigio EH, Mesulam M, Wang T, Sun L, Wang L, Lee AY, McGee WA, Chen X, Fushimi K, Zhu L, Wu JY. TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. Plos Genetics. 15: e1007947. PMID 31100073 DOI: 10.1371/Journal.Pgen.1007947  0.102
2021 Jiang S, Maphis NM, Binder J, Chisholm D, Weston L, Duran W, Peterson C, Zimmerman A, Mandell MA, Jett SD, Bigio E, Geula C, Mellios N, Weick JP, Rosenberg GA, et al. Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway. Cell Reports. 36: 109720. PMID 34551296 DOI: 10.1016/j.celrep.2021.109720  0.087
2015 Oboudiyat C, Bigio EH, Bonakdarpour B, Baker MC, Rademakers R, Weintraub S, Mesulam MM. Diffuse leukoencephalopathy with spheroids presenting as primary progressive aphasia Neurology. 85: 652-653. DOI: 10.1212/WNL.0000000000001851  0.078
1999 Bigio EH. The Brain Atlas: A Visual Guide to the Human Central Nervous System Archives of Neurology. 56: 1298-1298. DOI: 10.1001/ARCHNEUR.56.10.1298  0.055
2006 Schafernak KT, Bigio EH. West Nile virus encephalomyelitis with polio-like paralysis & nigral degeneration. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 33: 407-10. PMID 17168167  0.04
1990 Schnadig VJ, Bigio EH, Gourley WK, Stewart GD, Newton GA, Shabot JM. Identification of Campylobacter pylori by endoscopic brush cytology. Diagnostic Cytopathology. 6: 227-34. PMID 2209347  0.021
1989 Bigio EH, Haque AK. Disseminated cytomegalovirus infection presenting with acalculous cholecystitis and acute pancreatitis. Archives of Pathology & Laboratory Medicine. 113: 1287-9. PMID 2554845  0.01
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