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David R. Hinton, MD FRCPC Pathol - Publications

Affiliations: 
Pathology, Neurosurgery, Ophthamology  University of Southern California, Los Angeles, CA, United States 
Area:
Aging, Gene Therapy, Vision Research, Cellular Neurobiology
Website:
http://www.usc.edu/programs/pibbs/site/faculty/hinton_d.htm

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang M, Lau LI, Sreekumar PG, Spee C, Hinton DR, Sadda SR, Kannan R. Characterization and Regulation of Carrier Proteins of Mitochondrial Glutathione Uptake in Human Retinal Pigment Epithelium Cells. Investigative Ophthalmology & Visual Science. 60: 500-516. PMID 30707752 DOI: 10.1167/iovs.18-25686  0.36
2018 Sreekumar PG, Li Z, Wang W, Spee C, Hinton DR, Kannan R, Andrew MacKay J. Intra-vitreal αB crystallin fused to elastin-like polypeptide provides neuroprotection in a mouse model of age-related macular degeneration. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 29778783 DOI: 10.1016/j.jconrel.2018.05.014  0.36
2017 Jiao C, Eliott D, Spee C, He S, Wang K, Mullins RF, Hinton DR, Sohn EH. APOPTOSIS AND ANGIOFIBROSIS IN DIABETIC TRACTIONAL MEMBRANES AFTER VASCULAR ENDOTHELIAL GROWTH FACTOR INHIBITION: Results of a Prospective Trial. Report No. 2. Retina (Philadelphia, Pa.). PMID 29190236 DOI: 10.1097/IAE.0000000000001952  0.36
2017 Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, ... ... Hinton DR, et al. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nature Medicine. PMID 29176737 DOI: 10.1038/nm.4450  0.36
2017 Minasyan L, Sreekumar PG, Hinton DR, Kannan R. Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxidative Medicine and Cellular Longevity. 2017: 1675230. PMID 28814984 DOI: 10.1155/2017/1675230  0.36
2017 Sreekumar PG, Hinton DR, Kannan R. Endoplasmic reticulum-mitochondrial crosstalk: a novel role for the mitochondrial peptide humanin. Neural Regeneration Research. 12: 35-38. PMID 28250736 DOI: 10.4103/1673-5374.198970  0.36
2016 Matsunaga D, Sreekumar PG, Ishikawa K, Terasaki H, Barron E, Cohen P, Kannan R, Hinton DR. Humanin Protects RPE Cells from Endoplasmic Reticulum Stress-Induced Apoptosis by Upregulation of Mitochondrial Glutathione. Plos One. 11: e0165150. PMID 27783653 DOI: 10.1371/journal.pone.0165150  0.36
2016 Kochounian H, Zhang Z, Spee C, Hinton DR, Fong HK. Targeting of exon VI-skipping human RGR-opsin to the plasma membrane of pigment epithelium and co-localization with terminal complement complex C5b-9. Molecular Vision. 22: 213-23. PMID 27011730  0.36
2016 Sreekumar PG, Ishikawa K, Spee C, Mehta HH, Wan J, Yen K, Cohen P, Kannan R, Hinton DR. The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Investigative Ophthalmology & Visual Science. 57: 1238-1253. PMID 26990160 DOI: 10.1167/iovs.15-17053  0.36
2016 Ishikawa K, Sreekumar PG, Spee C, Nazari H, Zhu D, Kannan R, Hinton DR. αB-Crystallin Regulates Subretinal Fibrosis by Modulation of Epithelial-Mesenchymal Transition. The American Journal of Pathology. PMID 26878210 DOI: 10.1016/j.ajpath.2015.11.014  0.36
2015 Ishikawa K, He S, Terasaki H, Nazari H, Zhang H, Spee C, Kannan R, Hinton DR. Resveratrol inhibits epithelial-mesenchymal transition of retinal pigment epithelium and development of proliferative vitreoretinopathy. Scientific Reports. 5: 16386. PMID 26552368 DOI: 10.1038/srep16386  0.36
2015 He S, Barron E, Ishikawa K, Nazari Khanamiri H, Spee C, Zhou P, Kase S, Wang Z, Dustin LD, Hinton DR. Inhibition of DNA Methylation and Methyl-CpG-Binding Protein 2 Suppresses RPE Transdifferentiation: Relevance to Proliferative Vitreoretinopathy. Investigative Ophthalmology & Visual Science. 56: 5579-89. PMID 26305530 DOI: 10.1167/iovs.14-16258  0.36
2015 Zhang H, He S, Spee C, Ishikawa K, Hinton DR. SIRT1 mediated inhibition of VEGF/VEGFR2 signaling by Resveratrol and its relevance to choroidal neovascularization. Cytokine. 76: 549-52. PMID 26174951 DOI: 10.1016/j.cyto.2015.06.019  0.36
2015 Kannan R, Sreekumar PG, Hinton DR. Alpha crystallins in the retinal pigment epithelium and implications for the pathogenesis and treatment of age-related macular degeneration. Biochimica Et Biophysica Acta. PMID 26026469 DOI: 10.1016/j.bbagen.2015.05.016  0.36
2015 Chan N, He S, Spee CK, Ishikawa K, Hinton DR. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. Plos One. 10: e0120587. PMID 25807249 DOI: 10.1371/journal.pone.0120587  0.32
2015 Ishikawa K, Kannan R, Hinton DR. Molecular mechanisms of subretinal fibrosis in age-related macular degeneration. Experimental Eye Research. PMID 25773985 DOI: 10.1016/j.exer.2015.03.009  0.36
2015 Hirsch L, Nazari H, Sreekumar PG, Kannan R, Dustin L, Zhu D, Barron E, Hinton DR. TGF-β2 secretion from RPE decreases with polarization and becomes apically oriented. Cytokine. 71: 394-6. PMID 25496702 DOI: 10.1016/j.cyto.2014.11.014  0.36
2014 Kannan R, Hinton DR. Sodium iodate induced retinal degeneration: new insights from an old model. Neural Regeneration Research. 9: 2044-5. PMID 25657718 DOI: 10.4103/1673-5374.147927  0.36
2014 Hirano Y, Yasuma T, Mizutani T, Fowler BJ, Tarallo V, Yasuma R, Kim Y, Bastos-Carvalho A, Kerur N, Gelfand BD, Bogdanovich S, He S, Zhang X, Nozaki M, Ijima R, ... ... Hinton DR, et al. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nature Medicine. 20: 1372-5. PMID 25473914 DOI: 10.1038/nm.3671  0.32
2014 Zhou P, Kannan R, Spee C, Sreekumar PG, Dou G, Hinton DR. Protection of retina by αB crystallin in sodium iodate induced retinal degeneration. Plos One. 9: e98275. PMID 24874187 DOI: 10.1371/journal.pone.0098275  0.36
2014 Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay JA. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. Journal of Controlled Release : Official Journal of the Controlled Release Society. 191: 4-14. PMID 24780268 DOI: 10.1016/j.jconrel.2014.04.028  0.36
2014 Sonoda S, Nagineni CN, Kitamura M, Spee C, Kannan R, Hinton DR. Ceramide inhibits connective tissue growth factor expression by human retinal pigment epithelial cells. Cytokine. 68: 137-40. PMID 24758915 DOI: 10.1016/j.cyto.2014.03.011  0.36
2013 He S, Li X, Chan N, Hinton DR. Review: Epigenetic mechanisms in ocular disease. Molecular Vision. 19: 665-74. PMID 23559860  0.32
2013 Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton DR. Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Investigative Ophthalmology & Visual Science. 54: 2787-98. PMID 23532520 DOI: 10.1167/iovs.12-11571  0.36
2012 Sohn EH, He S, Kim LA, Salehi-Had H, Javaheri M, Spee C, Dustin L, Hinton DR, Eliott D. Angiofibrotic response to vascular endothelial growth factor inhibition in diabetic retinal detachment: report no. 1. Archives of Ophthalmology (Chicago, Ill. : 1960). 130: 1127-34. PMID 22965588 DOI: 10.1001/archophthalmol.2012.1611  0.36
2012 Dou G, Sreekumar PG, Spee C, He S, Ryan SJ, Kannan R, Hinton DR. Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction. Free Radical Biology & Medicine. 53: 1111-22. PMID 22781655 DOI: 10.1016/j.freeradbiomed.2012.06.042  0.36
2012 Kannan R, Sreekumar PG, Hinton DR. Novel roles for α-crystallins in retinal function and disease. Progress in Retinal and Eye Research. 31: 576-604. PMID 22721717 DOI: 10.1016/j.preteyeres.2012.06.001  0.36
2012 Sreekumar PG, Spee C, Ryan SJ, Cole SP, Kannan R, Hinton DR. Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux. Plos One. 7: e33420. PMID 22442691 DOI: 10.1371/journal.pone.0033420  0.36
2012 Xu J, Zhu D, Sonoda S, He S, Spee C, Ryan SJ, Hinton DR. Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9. Angiogenesis. 15: 213-27. PMID 22392094 DOI: 10.1007/s10456-012-9254-4  0.36
2011 Kannan R, Sreekumar PG, Hinton DR. VEGF and PEDF secretion in ARPE-19 and fhRPE cells. Investigative Ophthalmology & Visual Science. 52: 9047. PMID 22104197 DOI: 10.1167/iovs.11-8737  0.36
2011 Sreekumar PG, Hinton DR, Kannan R. Methionine sulfoxide reductase A: Structure, function and role in ocular pathology. World Journal of Biological Chemistry. 2: 184-92. PMID 21909460 DOI: 10.4331/wjbc.v2.i8.184  0.36
2011 Khankan R, Oliver N, He S, Ryan SJ, Hinton DR. Regulation of fibronectin-EDA through CTGF domain-specific interactions with TGFβ2 and its receptor TGFβRII. Investigative Ophthalmology & Visual Science. 52: 5068-78. PMID 21571675 DOI: 10.1167/iovs.11-7191  0.32
2011 Xu J, Zhu D, He S, Spee C, Ryan SJ, Hinton DR. Transcriptional regulation of bone morphogenetic protein 4 by tumor necrosis factor and its relationship with age-related macular degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2221-33. PMID 21411747 DOI: 10.1096/fj.10-178350  0.36
2011 Chothe PP, Gnana-Prakasam JP, Ananth S, Martin PM, Kannan R, Hinton DR, Smith SB, Ganapathy V. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochemical and Biophysical Research Communications. 405: 244-9. PMID 21219868 DOI: 10.1016/j.bbrc.2011.01.018  0.36
2011 Zhu D, Deng X, Spee C, Sonoda S, Hsieh CL, Barron E, Pera M, Hinton DR. Polarized secretion of PEDF from human embryonic stem cell-derived RPE promotes retinal progenitor cell survival. Investigative Ophthalmology & Visual Science. 52: 1573-85. PMID 21087957 DOI: 10.1167/iovs.10-6413  0.36
2010 Ye R, Mareninova OA, Barron E, Wang M, Hinton DR, Pandol SJ, Lee AS. Grp78 heterozygosity regulates chaperone balance in exocrine pancreas with differential response to cerulein-induced acute pancreatitis. The American Journal of Pathology. 177: 2827-36. PMID 20971738 DOI: 10.2353/ajpath.2010.100368  0.36
2010 Sreekumar PG, Kannan R, Kitamura M, Spee C, Barron E, Ryan SJ, Hinton DR. αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells. Plos One. 5: e12578. PMID 20949024 DOI: 10.1371/journal.pone.0012578  0.36
2010 Lim JI, Spee C, Hinton DR. A comparison of hypoxia-inducible factor-α in surgically excised neovascular membranes of patients with diabetes compared with idiopathic epiretinal membranes in nondiabetic patients. Retina (Philadelphia, Pa.). 30: 1472-8. PMID 20811317 DOI: 10.1097/IAE.0b013e3181d6df09  0.36
2010 Hua J, Spee C, Kase S, Rennel ES, Magnussen AL, Qiu Y, Varey A, Dhayade S, Churchill AJ, Harper SJ, Bates DO, Hinton DR. Recombinant human VEGF165b inhibits experimental choroidal neovascularization. Investigative Ophthalmology & Visual Science. 51: 4282-8. PMID 20237252 DOI: 10.1167/iovs.09-4360  0.36
2010 Sonoda S, Sreekumar PG, Kase S, Spee C, Ryan SJ, Kannan R, Hinton DR. Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration. Aging. 2: 28-42. PMID 20228934  0.36
2010 Zhou J, He S, Zhang N, Spee C, Zhou P, Ryan SJ, Kannan R, Hinton DR. Neutrophils compromise retinal pigment epithelial barrier integrity. Journal of Biomedicine & Biotechnology. 2010: 289360. PMID 20204129 DOI: 10.1155/2010/289360  0.36
2010 Kase S, He S, Sonoda S, Kitamura M, Spee C, Wawrousek E, Ryan SJ, Kannan R, Hinton DR. alphaB-crystallin regulation of angiogenesis by modulation of VEGF. Blood. 115: 3398-406. PMID 20023214 DOI: 10.1182/blood-2009-01-197095  0.36
2010 Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS. Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis. Cell Death and Differentiation. 17: 488-98. PMID 19816510 DOI: 10.1038/cdd.2009.144  0.36
2010 Zhu D, Sreekumar PG, Hinton DR, Kannan R. Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration. Vision Research. 50: 643-51. PMID 19765607 DOI: 10.1016/j.visres.2009.09.002  0.36
2010 He S, Kumar SR, Zhou P, Krasnoperov V, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Investigative Ophthalmology & Visual Science. 51: 543-52. PMID 19696168 DOI: 10.1167/iovs.09-3475  0.32
2010 Chothe PP, Thakkar SV, Gnana-Prakasam JP, Ananth S, Hinton DR, Kannan R, Smith SB, Martin PM, Ganapathy V. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 51: 413-20. PMID 19643969 DOI: 10.1167/iovs.09-4048  0.36
2009 Sonoda S, Spee C, Barron E, Ryan SJ, Kannan R, Hinton DR. A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells. Nature Protocols. 4: 662-73. PMID 19373231 DOI: 10.1038/nprot.2009.33  0.36
2009 Sreekumar PG, Kannan R, Hinton DR. There are three major families of crystallins: misnaming of alphaB crystallin. Acta Physiologica (Oxford, England). 195: 503; author reply 50. PMID 19291149 DOI: 10.1111/j.1748-1716.2009.01976_1.x  0.36
2009 Kim YH, He S, Kase S, Kitamura M, Ryan SJ, Hinton DR. Regulated secretion of complement factor H by RPE and its role in RPE migration. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 247: 651-9. PMID 19214553 DOI: 10.1007/s00417-009-1049-y  0.32
2009 Zhu D, Wu J, Spee C, Ryan SJ, Hinton DR. BMP4 mediates oxidative stress-induced retinal pigment epithelial cell senescence and is overexpressed in age-related macular degeneration. The Journal of Biological Chemistry. 284: 9529-39. PMID 19158083 DOI: 10.1074/jbc.M809393200  0.36
2009 Sreekumar PG, Ding Y, Ryan SJ, Kannan R, Hinton DR. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Experimental Eye Research. 88: 410-7. PMID 18996115 DOI: 10.1016/j.exer.2008.10.009  0.36
2008 He S, Chen Y, Khankan R, Barron E, Burton R, Zhu D, Ryan SJ, Oliver N, Hinton DR. Connective tissue growth factor as a mediator of intraocular fibrosis. Investigative Ophthalmology & Visual Science. 49: 4078-88. PMID 18450591 DOI: 10.1167/iovs.07-1302  0.32
2008 Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Investigative Ophthalmology & Visual Science. 49: 1210-20. PMID 18326751 DOI: 10.1167/iovs.07-0667  0.36
2008 He S, Yaung J, Kim YH, Barron E, Ryan SJ, Hinton DR. Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 246: 677-83. PMID 18278507 DOI: 10.1007/s00417-008-0770-2  0.32
2008 Yaung J, Kannan R, Wawrousek EF, Spee C, Sreekumar PG, Hinton DR. Exacerbation of retinal degeneration in the absence of alpha crystallins in an in vivo model of chemically induced hypoxia. Experimental Eye Research. 86: 355-65. PMID 18191123 DOI: 10.1016/j.exer.2007.11.007  0.36
2007 Yaung J, Jin M, Barron E, Spee C, Wawrousek EF, Kannan R, Hinton DR. alpha-Crystallin distribution in retinal pigment epithelium and effect of gene knockouts on sensitivity to oxidative stress. Molecular Vision. 13: 566-77. PMID 17438522  0.36
2007 Agrawal RN, He S, Spee C, Cui JZ, Ryan SJ, Hinton DR. In vivo models of proliferative vitreoretinopathy. Nature Protocols. 2: 67-77. PMID 17401340 DOI: 10.1038/nprot.2007.4  0.36
2006 He S, Incardona F, Jin M, Ryan SJ, Hinton DR. Thrombospondin-1 expression in RPE and choroidal neovascular membranes. Yan Ke Xue Bao = Eye Science / "Yan Ke Xue Bao" Bian Ji Bu. 22: 265-74. PMID 17378161  0.32
2006 Kannan R, Zhang N, Sreekumar PG, Spee CK, Rodriguez A, Barron E, Hinton DR. Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells. Molecular Vision. 12: 1649-59. PMID 17200665  0.36
2006 Sreekumar PG, Kannan R, de Silva AT, Burton R, Ryan SJ, Hinton DR. Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells. Biochemical and Biophysical Research Communications. 346: 1200-6. PMID 16793007 DOI: 10.1016/j.bbrc.2006.06.021  0.36
2006 Hoffmann S, He S, Ehren M, Ryan SJ, Wiedemann P, Hinton DR. MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes. Retina (Philadelphia, Pa.). 26: 454-61. PMID 16603966 DOI: 10.1097/01.iae.0000238549.74626.33  0.32
2006 Gamulescu MA, Chen Y, He S, Spee C, Jin M, Ryan SJ, Hinton DR. Transforming growth factor beta2-induced myofibroblastic differentiation of human retinal pigment epithelial cells: regulation by extracellular matrix proteins and hepatocyte growth factor. Experimental Eye Research. 83: 212-22. PMID 16563380 DOI: 10.1016/j.exer.2005.12.007  0.36
2006 Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 47: 287-94. PMID 16384975 DOI: 10.1167/iovs.05-0189  0.36
2006 Hangai M, He S, Hoffmann S, Lim JI, Ryan SJ, Hinton DR. Sequential induction of angiogenic growth factors by TNF-alpha in choroidal endothelial cells. Journal of Neuroimmunology. 171: 45-56. PMID 16288810 DOI: 10.1016/j.jneuroim.2005.09.018  0.32
2005 Lim JI, Spee C, Hangai M, Rocha J, Ying HS, Ryan SJ, Hinton DR. Neuropilin-1 expression by endothelial cells and retinal pigment epithelial cells in choroidal neovascular membranes. American Journal of Ophthalmology. 140: 1044-1050. PMID 16376649 DOI: 10.1016/j.ajo.2005.07.021  0.36
2005 He S, Ding Y, Zhou J, Krasnoperov V, Zozulya S, Kumar SR, Ryan SJ, Gill PS, Hinton DR. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Investigative Ophthalmology & Visual Science. 46: 4772-9. PMID 16303978 DOI: 10.1167/iovs.05-0502  0.32
2005 Jin M, Yaung J, Kannan R, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor protects RPE cells from apoptosis induced by glutathione depletion. Investigative Ophthalmology & Visual Science. 46: 4311-9. PMID 16249513 DOI: 10.1167/iovs.05-0353  0.36
2005 Sreekumar PG, Kannan R, Yaung J, Spee CK, Ryan SJ, Hinton DR. Protection from oxidative stress by methionine sulfoxide reductases in RPE cells. Biochemical and Biophysical Research Communications. 334: 245-53. PMID 15993845 DOI: 10.1016/j.bbrc.2005.06.081  0.36
2005 Zhou J, Pham L, Zhang N, He S, Gamulescu MA, Spee C, Ryan SJ, Hinton DR. Neutrophils promote experimental choroidal neovascularization. Molecular Vision. 11: 414-24. PMID 15988410  0.36
2005 Hoffmann S, He S, Jin M, Ehren M, Wiedemann P, Ryan SJ, Hinton DR. A selective cyclic integrin antagonist blocks the integrin receptors alphavbeta3 and alphavbeta5 and inhibits retinal pigment epithelium cell attachment, migration and invasion. Bmc Ophthalmology. 5: 16. PMID 15987521 DOI: 10.1186/1471-2415-5-16  0.32
2005 Chan CK, Pham LN, Zhou J, Spee C, Ryan SJ, Hinton DR. Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization. Laboratory Investigation; a Journal of Technical Methods and Pathology. 85: 721-33. PMID 15856049 DOI: 10.1038/labinvest.3700277  0.36
2004 Kannan R, Jin M, Gamulescu MA, Hinton DR. Ceramide-induced apoptosis: role of catalase and hepatocyte growth factor. Free Radical Biology & Medicine. 37: 166-75. PMID 15203188 DOI: 10.1016/j.freeradbiomed.2004.04.011  0.36
2004 Hinton DR, Spee C, He S, Weitz S, Usinger W, LaBree L, Oliver N, Lim JI. Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy. Diabetes Care. 27: 758-64. PMID 14988298  0.36
2004 Chan CK, Pham LN, Chinn C, Spee C, Ryan SJ, Akhurst RJ, Hinton DR. Mouse strain-dependent heterogeneity of resting limbal vasculature. Investigative Ophthalmology & Visual Science. 45: 441-7. PMID 14744883 DOI: 10.1167/iovs.03-0869  0.36
2004 Jin M, Chen Y, He S, Ryan SJ, Hinton DR. Hepatocyte growth factor and its role in the pathogenesis of retinal detachment. Investigative Ophthalmology & Visual Science. 45: 323-9. PMID 14691191 DOI: 10.1167/iovs.03-0355  0.32
2003 He S, Jin ML, Worpel V, Hinton DR. A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. Archives of Ophthalmology (Chicago, Ill. : 1960). 121: 1283-8. PMID 12963611 DOI: 10.1001/archopht.121.9.1283  0.32
2002 Jin M, Barron E, He S, Ryan SJ, Hinton DR. Regulation of RPE intercellular junction integrity and function by hepatocyte growth factor. Investigative Ophthalmology & Visual Science. 43: 2782-90. PMID 12147616  0.32
2002 Hinton DR, He S, Jin ML, Barron E, Ryan SJ. Novel growth factors involved in the pathogenesis of proliferative vitreoretinopathy. Eye (London, England). 16: 422-8. PMID 12101449 DOI: 10.1038/sj.eye.6700190  0.32
2001 Hangai M, Murata T, Miyawaki N, Spee C, Lim JI, He S, Hinton DR, Ryan SJ. Angiopoietin-1 upregulation by vascular endothelial growth factor in human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 42: 1617-25. PMID 11381069  0.36
2000 Jin M, He S, Wörpel V, Ryan SJ, Hinton DR. Promotion of adhesion and migration of RPE cells to provisional extracellular matrices by TNF-alpha. Investigative Ophthalmology & Visual Science. 41: 4324-32. PMID 11095634  0.32
2000 Hoffmann S, Masood R, Zhang Y, He S, Ryan SJ, Gill P, Hinton DR. Selective killing of RPE with a vascular endothelial growth factor chimeric toxin. Investigative Ophthalmology & Visual Science. 41: 2389-93. PMID 10892888  0.32
2000 Murata T, He S, Hangai M, Ishibashi T, Xi XP, Kim S, Hsueh WA, Ryan SJ, Law RE, Hinton DR. Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization. Investigative Ophthalmology & Visual Science. 41: 2309-17. PMID 10892878  0.32
2000 Murata T, Cui J, Taba KE, Oh JY, Spee C, Hinton DR, Ryan SJ. The possibility of gene therapy for the treatment of choroidal neovascularization. Ophthalmology. 107: 1364-73. PMID 10889114 DOI: 10.1016/S0161-6420(00)00147-0  0.36
2000 Cui JZ, Kimura H, Spee C, Thumann G, Hinton DR, Ryan SJ. Natural history of choroidal neovascularization induced by vascular endothelial growth factor in the primate. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 238: 326-33. PMID 10853932  0.36
1999 Stohlman SA, Pei L, Cua DJ, Li Z, Hinton DR. Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. Journal of Immunology (Baltimore, Md. : 1950). 163: 6338-44. PMID 10570329  0.36
1999 Zhao MW, Jin ML, He S, Spee C, Ryan SJ, Hinton DR. A distinct integrin-mediated phagocytic pathway for extracellular matrix remodeling by RPE cells. Investigative Ophthalmology & Visual Science. 40: 2713-23. PMID 10509670  0.36
1999 Thumann G, Bartz-Schmidt KU, El Bakri H, Schraermeyer U, Spee C, Cui JZ, Hinton DR, Ryan SJ, Heimann K. Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits. Transplantation. 68: 195-201. PMID 10440387 DOI: 10.1097/00007890-199907270-00006  0.36
1999 Casella AM, Taba KE, Kimura H, Spee C, Cardillo JA, Ryan SJ, Hinton DR. Retinal pigment epithelial cells are heterogeneous in their expression of MHC-II after stimulation with interferon-gamma. Experimental Eye Research. 68: 423-30. PMID 10192799 DOI: 10.1006/exer.1998.0621  0.36
1999 Kimura H, Spee C, Sakamoto T, Hinton DR, Ogura Y, Tabata Y, Ikada Y, Ryan SJ. Cellular response in subretinal neovascularization induced by bFGF-impregnated microspheres. Investigative Ophthalmology & Visual Science. 40: 524-8. PMID 9950614  0.36
1998 Murata T, Hangai M, Ishibashi T, Spee C, Gordon EM, Anderson WF, Hinton DR, Ryan SJ. Retrovirus-mediated gene transfer to photocoagulation-induced choroidal neovascular membranes. Investigative Ophthalmology & Visual Science. 39: 2474-8. PMID 9804157  0.36
1998 Hoffmann S, Spee C, Murata T, Cui JZ, Ryan SJ, Hinton DR. Rapid isolation of choriocapillary endothelial cells by Lycopersicon esculentum-coated Dynabeads. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 236: 779-84. PMID 9801894 DOI: 10.1007/s004170050158  0.36
1998 He PM, He S, Garner JA, Ryan SJ, Hinton DR. Retinal pigment epithelial cells secrete and respond to hepatocyte growth factor. Biochemical and Biophysical Research Communications. 249: 253-7. PMID 9705867 DOI: 10.1006/bbrc.1998.9087  0.32
1998 Hoffman S, Gopalakrishna R, Gundimeda U, Murata T, Spee C, Ryan SJ, Hinton DR. Verapamil inhibits proliferation, migration and protein kinase C activity in human retinal pigment epithelial cells. Experimental Eye Research. 67: 45-52. PMID 9702177 DOI: 10.1006/exer.1998.0491  0.36
1998 Murata T, Hoffmann S, Ishibashi T, Spee C, Gordon EM, Anderson WF, Hinton DR, Ryan SJ. Retrovirus-mediated gene transfer targeted to retinal photocoagulation sites. Diabetologia. 41: 500-6. PMID 9628265 DOI: 10.1007/s001250050938  0.36
1998 Sakamoto T, Spee C, Scuric Z, Gordon EM, Hinton DR, Anderson WF, Ryan SJ. Ability of retroviral transduction to modify the angiogenic characteristics of RPE cells. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 236: 220-9. PMID 9541827 DOI: 10.1007/s004170050068  0.36
1998 Hinton DR, He S, Graf K, Yang D, Hsueh WA, Ryan SJ, Law RE. Mitogen-activated protein kinase activation mediates PDGF-directed migration of RPE cells. Experimental Cell Research. 239: 11-5. PMID 9511719 DOI: 10.1006/excr.1997.3873  0.32
1998 Hinton DR, He S, Lopez PF. Apoptosis in surgically excised choroidal neovascular membranes in age-related macular degeneration. Archives of Ophthalmology (Chicago, Ill. : 1960). 116: 203-9. PMID 9488273  0.32
1997 Kimura H, Harris MS, Sakamoto T, Gopalakrishna R, Gundimeda U, Cui JZ, Spee C, Hinton DR, Ryan SJ. Hypericin inhibits choroidal endothelial cell proliferation and cord formation in vitro. Current Eye Research. 16: 967-72. PMID 9330847 DOI: 10.1076/ceyr.16.10.967.9019  0.36
1997 Murata T, Kimura H, Sakamoto T, Osusky R, Spee C, Stout TJ, Hinton DR, Ryan SJ. Ocular gene therapy: experimental studies and clinical possibilities. Ophthalmic Research. 29: 242-51. PMID 9323715  0.36
1997 Schubert CA, Kimura H, Spee C, Hinton DR, Gordon EM, Anderson WF, Ryan SJ. Retrovirus-mediated transfer of the suicide gene into retinal pigment epithelial cells in vitro. Current Eye Research. 16: 656-62. PMID 9222082 DOI: 10.1076/ceyr.16.7.656.5066  0.36
1997 Yoo JS, Sakamoto T, Spee C, Kimura H, Harris MS, Hinton DR, Kay EP, Ryan SJ. cis-Hydroxyproline inhibits proliferation, collagen synthesis, attachment, and migration of cultured bovine retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 38: 520-8. PMID 9040485  0.36
1996 Kimura H, Sakamoto T, Cardillo JA, Spee C, Hinton DR, Gordon EM, Anderson WF, Ryan SJ. Retrovirus-mediated suicide gene transduction in the vitreous cavity of the eye: feasibility in prevention of proliferative vitreoretinopathy. Human Gene Therapy. 7: 799-808. PMID 8860832 DOI: 10.1089/hum.1996.7.7-799  0.36
1996 Sakamoto T, Hinton DR, Kimura H, Spee C, Gopalakrishna R, Ryan SJ. Vitamin E succinate inhibits proliferation and migration of retinal pigment epithelial cells in vitro: therapeutic implication for proliferative vitreoretinopathy. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv FüR Klinische Und Experimentelle Ophthalmologie. 234: 186-92. PMID 8720718 DOI: 10.1007/BF00462031  0.36
1996 Harris MS, Sakamoto T, Kimura H, He S, Spee C, Gopalakrishna R, Gundimeda U, Yoo JS, Hinton DR, Ryan SJ. Hypericin inhibits cell growth and induces apoptosis in retinal pigment epithelial cells: possible involvement of protein kinase C. Current Eye Research. 15: 255-62. PMID 8654105  0.36
1996 Sippy BD, Hofman FM, Wright AD, Wang JL, Gopalakrishna R, Gundimeda U, He S, Ryan SJ, Hinton DR. Induction of intercellular adhesion molecule-1 by tumor necrosis factor-alpha through the 55-kDa receptor is dependent on protein kinase C in human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 37: 597-606. PMID 8595959  0.32
1995 Sakamoto T, Kimura H, Scuric Z, Spee C, Gordon EM, Hinton DR, Anderson WF, Ryan SJ. Inhibition of experimental proliferative vitreoretinopathy by retroviral vector-mediated transfer of suicide gene. Can proliferative vitreoretinopathy be a target of gene therapy? Ophthalmology. 102: 1417-24. PMID 9097787  0.36
1995 Sakamoto T, Sakamoto H, Hinton DR, Spee C, Ishibashi T, Ryan SJ. In vitro studies of human choroidal endothelial cells. Current Eye Research. 14: 621-7. PMID 8529396  0.36
1995 Sakamoto T, Soriano D, Nassaralla J, Murphy TL, Oganesian A, Spee C, Hinton DR, Ryan SJ. Effect of intravitreal administration of indomethacin on experimental subretinal neovascularization in the subhuman primate. Archives of Ophthalmology. 113: 222-6. PMID 7864756  0.36
1995 Kimura H, Sakamoto T, Hinton DR, Spee C, Ogura Y, Tabata Y, Ikada Y, Ryan SJ. A new model of subretinal neovascularization in the rabbit. Investigative Ophthalmology & Visual Science. 36: 2110-9. PMID 7657549  0.36
1995 Murphy TL, Sakamoto T, Hinton DR, Spee C, Gundimeda U, Soriano D, Gopalakrishna R, Ryan SJ. Migration of retinal pigment epithelium cells in vitro is regulated by protein kinase C. Experimental Eye Research. 60: 683-95. PMID 7641851 DOI: 10.1016/S0014-4835(05)80010-7  0.36
1995 Sippy BD, Hofman FM, He S, Osusky R, Sheu SJ, Walker SM, Ryan SJ, Hinton DR. SV40-immortalized and primary cultured human retinal pigment epithelial cells share similar patterns of cytokine-receptor expression and cytokine responsiveness. Current Eye Research. 14: 495-503. PMID 7545567  0.32
1995 Sakamoto T, Ishibashi T, Kimura H, Yoshikawa H, Spee C, Harris MS, Hinton DR, Ryan SJ. Effect of tecogalan sodium on angiogenesis in vitro by choroidal endothelial cells. Investigative Ophthalmology & Visual Science. 36: 1076-83. PMID 7537258  0.36
1995 Sakamoto T, Sakamoto H, Murphy TL, Spee C, Soriano D, Ishibashi T, Hinton DR, Ryan SJ. Vessel formation by choroidal endothelial cells in vitro is modulated by retinal pigment epithelial cells. Archives of Ophthalmology. 113: 512-20. PMID 7536000  0.36
1994 Couldwell WT, Hinton DR, He S, Chen TC, Sebat I, Weiss MH, Law RE. Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines. Febs Letters. 345: 43-6. PMID 8194597  0.32
1994 He S, Wang HM, Ye J, Ogden TE, Ryan SJ, Hinton DR. Dexamethasone induced proliferation of cultured retinal pigment epithelial cells. Current Eye Research. 13: 257-61. PMID 8033587  0.32
1994 Jones KD, Couldwell WT, Hinton DR, Su Y, He S, Anker L, Law RE. Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells. Biochemical and Biophysical Research Communications. 205: 1681-7. PMID 7811252  0.32
1994 Couldwell WT, Gopalakrishna R, Hinton DR, He S, Weiss MH, Law RE, Apuzzo ML, Law RE. Hypericin: a potential antiglioma therapy. Neurosurgery. 35: 705-9; discussion 70. PMID 7808614  0.32
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