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Khalid Iqbal, PhD - Publications

Affiliations: 
Neurochemistry New York State Institute for Basic Research in Disabilities, NY, United States 
Area:
http://www.biomedexperts.com/Profile.bme/1727176/Khalid_Iqbal
Website:
http://www.omr.state.ny.us/ws/ws_ibr_resources.jsp

229 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jin N, Shi R, Jiang Y, Chu D, Gong CX, Iqbal K, Liu F. Glycogen synthase kinase-3β suppresses the expression of protein phosphatase methylesterase-1 through β-catenin. Aging. 11. PMID 31714894 DOI: 10.18632/aging.102413  0.84
2019 Iqbal K, Liu F, Gong C, Dai C, Hu W. Why delay in effective treatment for Alzheimer's disease and related conditions. Progress in Molecular Biology and Translational Science. 168: 243-256. PMID 31699318 DOI: 10.1016/bs.pmbts.2019.08.002  0.76
2019 Gu J, Hu W, Tan X, Qu S, Chu D, Gong CX, Iqbal K, Liu F. Elevation of Casein kinase 1ε is associated with TDP-43 and tau pathologies in Alzheimer's disease. Brain Pathology (Zurich, Switzerland). PMID 31376192 DOI: 10.1111/bpa.12775  0.84
2019 Li H, Dai CL, Gu JH, Peng S, Li J, Yu Q, Iqbal K, Liu F, Gong CX. Intranasal Administration of Insulin Reduces Chronic Behavioral Abnormality and Neuronal Apoptosis Induced by General Anesthesia in Neonatal Mice. Frontiers in Neuroscience. 13: 706. PMID 31354415 DOI: 10.3389/fnins.2019.00706  0.84
2019 Yu Q, Dai CL, Zhang Y, Chen Y, Wu Z, Iqbal K, Liu F, Gong CX. Intranasal Insulin Increases Synaptic Protein Expression and Prevents Anesthesia-Induced Cognitive Deficits Through mTOR-eEF2 Pathway. Journal of Alzheimer's Disease : Jad. PMID 31306126 DOI: 10.3233/JAD-190280  0.84
2019 Miao J, Shi R, Li L, Chen F, Zhou Y, Tung YC, Hu W, Gong CX, Iqbal K, Liu F. Pathological Tau From Alzheimer's Brain Induces Site-Specific Hyperphosphorylation and SDS- and Reducing Agent-Resistant Aggregation of Tau . Frontiers in Aging Neuroscience. 11: 34. PMID 30890929 DOI: 10.3389/fnagi.2019.00034  0.84
2019 Zhang Y, Wu F, Iqbal K, Gong CX, Hu W, Liu F. Subacute to chronic Alzheimer-like alterations after controlled cortical impact in human tau transgenic mice. Scientific Reports. 9: 3789. PMID 30846870 DOI: 10.1038/s41598-019-40678-4  0.84
2019 Li L, Jiang Y, Hu W, Tung YC, Dai C, Chu D, Gong CX, Iqbal K, Liu F. Pathological Alterations of Tau in Alzheimer's Disease and 3xTg-AD Mouse Brains. Molecular Neurobiology. PMID 30734228 DOI: 10.1007/s12035-019-1507-4  0.84
2018 Gu J, Chen F, Chu D, Lu Y, Iqbal K, Gong CX, Liu F. Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10. Journal of Alzheimer's Disease : Jad. PMID 30475774 DOI: 10.3233/JAD-180882  0.84
2018 Dai CL, Gu JH, Liu F, Iqbal K, Gong CX. Neuronal O-GlcNAc transferase regulates appetite, body weight, and peripheral insulin resistance. Neurobiology of Aging. 70: 40-50. PMID 29944994 DOI: 10.1016/j.neurobiolaging.2018.05.036  0.84
2018 Hu W, Tung YC, Zhang Y, Liu F, Iqbal K. Involvement of Activation of Asparaginyl Endopeptidase in Tau Hyperphosphorylation in Repetitive Mild Traumatic Brain Injury. Journal of Alzheimer's Disease : Jad. PMID 29889065 DOI: 10.3233/JAD-180177  0.76
2018 Basurto-Islas G, Gu JH, Tung YC, Liu F, Iqbal K. Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia. Journal of Alzheimer's Disease : Jad. PMID 29689717 DOI: 10.3233/JAD-170715  0.76
2018 Gu J, Jin N, Ma D, Chu D, Iqbal K, Gong CX, Liu F. Calpain I Activation Causes GLUT3 Proteolysis and Downregulation of O-GlcNAcylation in Alzheimer's Disease Brain. Journal of Alzheimer's Disease : Jad. 62: 1737-1746. PMID 29614685 DOI: 10.3233/JAD-171047  0.84
2018 Gong CX, Liu F, Iqbal K. Multifactorial Hypothesis and Multi-Targets for Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 29562523 DOI: 10.3233/JAD-179921  0.84
2018 Iqbal K, Liu F, Gong CX. Recent developments with tau-based drug discovery. Expert Opinion On Drug Discovery. 1-12. PMID 29493301 DOI: 10.1080/17460441.2018.1445084  0.84
2018 Zhou Y, Shi J, Chu D, Hu W, Guan Z, Gong CX, Iqbal K, Liu F. Relevance of Phosphorylation and Truncation of Tau to the Etiopathogenesis of Alzheimer's Disease. Frontiers in Aging Neuroscience. 10: 27. PMID 29472853 DOI: 10.3389/fnagi.2018.00027  0.84
2018 Jin N, Ma D, Gu J, Shi J, Xu X, Iqbal K, Gong CX, Liu F, Chu D. O-GlcNAcylation modulates PKA-CREB signaling in a manner specific to PKA catalytic subunit isoforms. Biochemical and Biophysical Research Communications. PMID 29427667 DOI: 10.1016/j.bbrc.2018.02.053  0.84
2018 Dai CL, Hu W, Tung YC, Liu F, Gong CX, Iqbal K. Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice. Alzheimer's Research & Therapy. 10: 13. PMID 29386065 DOI: 10.1186/s13195-018-0341-7  0.84
2018 Gu J, Wang W, Miao S, Chen F, Wu F, Hu W, Iqbal K, Gong CX, Liu F. Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion. Febs Letters. PMID 29334120 DOI: 10.1002/1873-3468.12976  0.84
2017 Chen C, Gu J, Basurto-Islas G, Jin N, Wu F, Gong CX, Iqbal K, Liu F. Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer's disease. Scientific Reports. 7: 13478. PMID 29044200 DOI: 10.1038/s41598-017-13791-5  0.84
2017 Hu W, Wu F, Zhang Y, Gong CX, Iqbal K, Liu F. Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau Pathogenesis. Frontiers in Aging Neuroscience. 9: 311. PMID 29021756 DOI: 10.3389/fnagi.2017.00311  0.84
2017 Gu JH, Shi J, Dai CL, Ge JB, Zhao Y, Chen Y, Yu Q, Qin ZH, Iqbal K, Liu F, Gong CX. O-GlcNAcylation Reduces Ischemia-Reperfusion-Induced Brain Injury. Scientific Reports. 7: 10686. PMID 28878265 DOI: 10.1038/s41598-017-10635-0  0.84
2017 Chen Y, Dai CL, Wu Z, Iqbal K, Liu F, Zhang B, Gong CX. Intranasal Insulin Prevents Anesthesia-Induced Cognitive Impairment and Chronic Neurobehavioral Changes. Frontiers in Aging Neuroscience. 9: 136. PMID 28539885 DOI: 10.3389/fnagi.2017.00136  0.84
2017 Gu J, Chen F, Iqbal K, Gong CX, Wang X, Liu F. Transactive response DNA-binding protein 43 (TDP-43) regulates alternative splicing of tau exon 10: implications for the pathogenesis of tauopathies. The Journal of Biological Chemistry. PMID 28487370 DOI: 10.1074/jbc.M117.783498  0.84
2017 Kazim SF, Chuang SC, Zhao W, Wong RK, Bianchi R, Iqbal K. Early-Onset Network Hyperexcitability in Presymptomatic Alzheimer's Disease Transgenic Mice Is Suppressed by Passive Immunization with Anti-Human APP/Aβ Antibody and by mGluR5 Blockade. Frontiers in Aging Neuroscience. 9: 71. PMID 28392767 DOI: 10.3389/fnagi.2017.00071  0.8
2017 Yin X, Jin N, Shi J, Zhang Y, Wu Y, Gong CX, Iqbal K, Liu F. Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome mice. Scientific Reports. 7: 619. PMID 28377597 DOI: 10.1038/s41598-017-00682-y  0.84
2017 Kazim SF, Blanchard J, Bianchi R, Iqbal K. Early neurotrophic pharmacotherapy rescues developmental delay and Alzheimer's-like memory deficits in the Ts65Dn mouse model of Down syndrome. Scientific Reports. 7: 45561. PMID 28368015 DOI: 10.1038/srep45561  0.8
2017 Gu J, Wu F, Xu W, Shi J, Hu W, Jin N, Qian W, Wang X, Iqbal K, Gong CX, Liu F. TDP-43 suppresses tau expression via promoting its mRNA instability. Nucleic Acids Research. PMID 28335005 DOI: 10.1093/nar/gkx175  0.84
2017 Jin N, Wu Y, Xu W, Gong CX, Iqbal K, Liu F. C-terminal truncation of GSK-3β enhances its dephosphorylation by PP2A. Febs Letters. PMID 28267204 DOI: 10.1002/1873-3468.12617  0.84
2017 Dai CL, Tung YC, Liu F, Gong CX, Iqbal K. Tau passive immunization inhibits not only tau but also Aβ pathology. Alzheimer's Research & Therapy. 9: 1. PMID 28073379 DOI: 10.1186/s13195-016-0227-5  0.84
2016 Kazim SF, Iqbal K. Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease. Molecular Neurodegeneration. 11: 50. PMID 27400746 DOI: 10.1186/s13024-016-0119-y  1
2016 Snyder HM, Cardenas-Aguayo Mdel C, Alonso A, Bain L, Iqbal K, Carrillo MC. Alzheimer's disease research in Ibero America. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 749-54. PMID 27288539 DOI: 10.1016/j.jalz.2016.04.007  0.8
2016 Hu W, Zhang X, Tung YC, Xie S, Liu F, Iqbal K. Hyperphosphorylation determines both the spread and the morphology of tau pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27133892 DOI: 10.1016/j.jalz.2016.01.014  0.76
2016 Gong CX, Liu F, Iqbal K. O-GlcNAcylation: A regulator of tau pathology and neurodegeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27126545 DOI: 10.1016/j.jalz.2016.02.011  0.84
2016 Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, ... Iqbal K, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet. Neurology. 15: 455-532. PMID 26987701 DOI: 10.1016/S1474-4422(16)00062-4  1
2016 Zhang Y, Dai CL, Chen Y, Iqbal K, Liu F, Gong CX. Intranasal Insulin Prevents Anesthesia-Induced Spatial Learning and Memory Deficit in Mice. Scientific Reports. 6: 21186. PMID 26879001 DOI: 10.1038/srep21186  1
2016 Xie S, Jin N, Gu J, Shi J, Sun J, Chu D, Zhang L, Dai CL, Gu JH, Gong CX, Iqbal K, Liu F. O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: a mechanism linked to learning and memory deficits in Alzheimer's disease. Aging Cell. PMID 26840030 DOI: 10.1111/acel.12449  1
2016 Wang Y, Zhang Y, Hu W, Xie S, Gong CX, Iqbal K, Liu F. Corrigendum: Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Scientific Reports. 6: 17241. PMID 26738441 DOI: 10.1038/srep17241  0.84
2015 Wang X, Blanchard J, Grundke-Iqbal I, Iqbal K. Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment. Plos One. 10: e0145441. PMID 26697860 DOI: 10.1371/journal.pone.0145441  1
2015 Iqbal K, Liu F, Gong CX. Tau and neurodegenerative disease: the story so far. Nature Reviews. Neurology. PMID 26635213 DOI: 10.1038/nrneurol.2015.225  0.84
2015 Wang Y, Zhang Y, Hu W, Xie S, Gong CX, Iqbal K, Liu F. Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation. Scientific Reports. 5: 15709. PMID 26511732 DOI: 10.1038/srep15709  0.84
2015 Chu D, Tan J, Xie S, Jin N, Yin X, Gong CX, Iqbal K, Liu F. GSK-3β is Dephosphorylated by PP2A in a Leu309 Methylation-Independent Manner. Journal of Alzheimer's Disease : Jad. PMID 26484916 DOI: 10.3233/JAD-150497  1
2015 Shi J, Gu JH, Dai CL, Gu J, Jin X, Sun J, Iqbal K, Liu F, Gong CX. O-GlcNAcylation regulates ischemia-induced neuronal apoptosis through AKT signaling. Scientific Reports. 5: 14500. PMID 26412745 DOI: 10.1038/srep14500  0.84
2015 Khatoon S, Chalbot S, Bolognin S, Puoliväli J, Iqbal K. Elevated Tau Level in Aged Rat Cerebrospinal Fluid Reduced by Treatment with a Neurotrophic Compound. Journal of Alzheimer's Disease : Jad. 47: 557-64. PMID 26401692 DOI: 10.3233/JAD-142799  0.6
2015 Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, Ji Y, Cao M, Gu X, Ding F, Iqbal K, Gong CX, Liu F. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. The Journal of Biological Chemistry. 290: 15219-37. PMID 25918155 DOI: 10.1074/jbc.M115.645507  1
2015 Kazim SF, Cardenas-Aguayo Mdel C, Arif M, Blanchard J, Fayyaz F, Grundke-Iqbal I, Iqbal K. Sera from children with autism induce autistic features which can be rescued with a CNTF small peptide mimetic in rats. Plos One. 10: e0118627. PMID 25769033 DOI: 10.1371/journal.pone.0118627  1
2015 Jin N, Yin X, Yu D, Cao M, Gong CX, Iqbal K, Ding F, Gu X, Liu F. Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease. Scientific Reports. 5: 8187. PMID 25641096 DOI: 10.1038/srep08187  1
2015 Wang X, Blanchard J, Tung YC, Grundke-Iqbal I, Iqbal K. Inhibition of Protein Phosphatase-2A (PP2A) by I1PP2A Leads to Hyperphosphorylation of Tau, Neurodegeneration, and Cognitive Impairment in Rats. Journal of Alzheimer's Disease : Jad. 45: 423-35. PMID 25589718 DOI: 10.3233/JAD-142403  1
2015 Chohan MO, Bragina O, Kazim SF, Statom G, Baazaoui N, Bragin D, Iqbal K, Nemoto E, Yonas H. Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury. Neurosurgery. 76: 201-14; discussion 2. PMID 25255260 DOI: 10.1227/NEU.0000000000000577  0.8
2015 Dai CL, Chen X, Kazim SF, Liu F, Gong CX, Grundke-Iqbal I, Iqbal K. Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 607-17. PMID 25233799 DOI: 10.1007/s00702-014-1315-y  1
2015 Wang Y, Yang R, Gu J, Yin X, Jin N, Xie S, Wang Y, Chang H, Qian W, Shi J, Iqbal K, Gong CX, Cheng C, Liu F. Cross talk between PI3K-AKT-GSK-3β and PP2A pathways determines tau hyperphosphorylation. Neurobiology of Aging. 36: 188-200. PMID 25219467 DOI: 10.1016/j.neurobiolaging.2014.07.035  0.84
2015 Yu Y, Li X, Blanchard J, Li Y, Iqbal K, Liu F, Gong CX. Insulin sensitizers improve learning and attenuate tau hyperphosphorylation and neuroinflammation in 3xTg-AD mice. Journal of Neural Transmission (Vienna, Austria : 1996). 122: 593-606. PMID 25113171 DOI: 10.1007/s00702-014-1294-z  0.84
2015 Liu SJ, Iqbal K, Shallow S, Speers S, Rizzo E, Gerard K, Poissant T, Klevens RM. Characterization of chronic hepatitis B cases among foreign-born persons in six population-based surveillance sites, United States 2001-2010. Journal of Immigrant and Minority Health / Center For Minority Public Health. 17: 7-12. PMID 24705737 DOI: 10.1007/s10903-014-0012-0  0.32
2014 Iqbal K, Kazim SF, Bolognin S, Blanchard J. Shifting balance from neurodegeneration to regeneration of the brain: a novel therapeutic approach to Alzheimer's disease and related neurodegenerative conditions. Neural Regeneration Research. 9: 1518-9. PMID 25317168 DOI: 10.4103/1673-5374.139477  0.8
2014 Arif M, Wei J, Zhang Q, Liu F, Basurto-Islas G, Grundke-Iqbal I, Iqbal K. Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau. The Journal of Biological Chemistry. 289: 27677-91. PMID 25128526 DOI: 10.1074/jbc.M114.565358  1
2014 Suryaprasad AG, White JZ, Xu F, Eichler BA, Hamilton J, Patel A, Hamdounia SB, Church DR, Barton K, Fisher C, Macomber K, Stanley M, Guilfoyle SM, Sweet K, Liu S, ... Iqbal K, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006-2012. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 59: 1411-9. PMID 25114031 DOI: 10.1093/cid/ciu643  0.36
2014 Kazim SF, Blanchard J, Dai CL, Tung YC, LaFerla FM, Iqbal IG, Iqbal K. Disease modifying effect of chronic oral treatment with a neurotrophic peptidergic compound in a triple transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 71: 110-30. PMID 25046994 DOI: 10.1016/j.nbd.2014.07.001  1
2014 Basurto-Islas G, Blanchard J, Tung YC, Fernandez JR, Voronkov M, Stock M, Zhang S, Stock JB, Iqbal K. Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease. Neurobiology of Aging. 35: 2701-12. PMID 25034344 DOI: 10.1016/j.neurobiolaging.2014.06.012  1
2014 Chen Y, Zhao Y, Dai CL, Liang Z, Run X, Iqbal K, Liu F, Gong CX. Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Experimental Neurology. 261: 610-9. PMID 24918340 DOI: 10.1016/j.expneurol.2014.06.004  0.84
2014 Chen Y, Run X, Liang Z, Zhao Y, Dai CL, Iqbal K, Liu F, Gong CX. Intranasal insulin prevents anesthesia-induced hyperphosphorylation of tau in 3xTg-AD mice. Frontiers in Aging Neuroscience. 6: 100. PMID 24910612 DOI: 10.3389/fnagi.2014.00100  0.84
2014 Bolognin S, Buffelli M, Puoliväli J, Iqbal K. Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound. Neurobiology of Aging. 35: 2134-46. PMID 24702821 DOI: 10.1016/j.neurobiolaging.2014.02.017  0.52
2014 Zhao Y, Gu JH, Dai CL, Liu Q, Iqbal K, Liu F, Gong CX. Chronic cerebral hypoperfusion causes decrease of O-GlcNAcylation, hyperphosphorylation of tau and behavioral deficits in mice. Frontiers in Aging Neuroscience. 6: 10. PMID 24575038 DOI: 10.3389/fnagi.2014.00010  0.84
2014 Iqbal K, Liu F, Gong CX. Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles. Biochemical Pharmacology. 88: 631-9. PMID 24418409 DOI: 10.1016/j.bcp.2014.01.002  0.84
2014 Arif M, Kazim SF, Grundke-Iqbal I, Garruto RM, Iqbal K. Tau pathology involves protein phosphatase 2A in parkinsonism-dementia of Guam. Proceedings of the National Academy of Sciences of the United States of America. 111: 1144-9. PMID 24395787 DOI: 10.1073/pnas.1322614111  1
2014 Iqbal K, Gong CX, Liu F. Microtubule-associated protein tau as a therapeutic target in Alzheimer's disease. Expert Opinion On Therapeutic Targets. 18: 307-18. PMID 24387228 DOI: 10.1517/14728222.2014.870156  0.84
2014 Wang X, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K. Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection. Acta Neuropathologica. 127: 243-56. PMID 24136402 DOI: 10.1007/s00401-013-1175-9  1
2014 Chen C, Jin N, Qian W, Liu W, Tan X, Ding F, Gu X, Iqbal K, Gong CX, Zuo J, Liu F. Cyclic AMP-dependent protein kinase enhances SC35-promoted Tau exon 10 inclusion. Molecular Neurobiology. 49: 615-24. PMID 24037441 DOI: 10.1007/s12035-013-8542-3  0.84
2014 Chen Y, Liang Z, Tian Z, Blanchard J, Dai CL, Chalbot S, Iqbal K, Liu F, Gong CX. Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice. Molecular Neurobiology. 49: 547-62. PMID 23996345 DOI: 10.1007/s12035-013-8539-y  0.84
2013 Iqbal K, Flory M, Soininen H. Clinical symptoms and symptom signatures of Alzheimer's disease subgroups. Journal of Alzheimer's Disease : Jad. 37: 475-81. PMID 24002184 DOI: 10.3233/JAD-130899  1
2013 Iqbal K, Gong CX, Liu F. Hyperphosphorylation-induced tau oligomers. Frontiers in Neurology. 4: 112. PMID 23966973 DOI: 10.3389/fneur.2013.00112  0.84
2013 Qian W, Jin N, Shi J, Yin X, Jin X, Wang S, Cao M, Iqbal K, Gong CX, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) enhances tau expression. Journal of Alzheimer's Disease : Jad. 37: 529-38. PMID 23948904 DOI: 10.3233/JAD-130824  0.84
2013 Iqbal K, Bolognin S, Wang X, Basurto-Islas G, Blanchard J, Tung YC. Animal models of the sporadic form of Alzheimer's disease: focus on the disease and not just the lesions. Journal of Alzheimer's Disease : Jad. 37: 469-74. PMID 23948903 DOI: 10.3233/JAD-130827  0.6
2013 Ding J, He Z, Ruan J, Ma Z, Liu Y, Gong C, Iqbal K, Sun S, Chen H. Role of ciliary neurotrophic factor in the proliferation and differentiation of neural stem cells. Journal of Alzheimer's Disease : Jad. 37: 587-92. PMID 23948898 DOI: 10.3233/JAD-130527  0.48
2013 Dai CL, Shi J, Chen Y, Iqbal K, Liu F, Gong CX. Inhibition of protein synthesis alters protein degradation through activation of protein kinase B (AKT). The Journal of Biological Chemistry. 288: 23875-83. PMID 23843462 DOI: 10.1074/jbc.M112.445148  0.84
2013 Basurto-Islas G, Grundke-Iqbal I, Tung YC, Liu F, Iqbal K. Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease. The Journal of Biological Chemistry. 288: 17495-507. PMID 23640887 DOI: 10.1074/jbc.M112.446070  1
2013 Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/j.jalz.2013.01.010  1
2013 Wanka L, Iqbal K, Schreiner PR. The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives. Chemical Reviews. 113: 3516-604. PMID 23432396 DOI: 10.1021/cr100264t  1
2013 Jin N, Qian W, Yin X, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease. Nucleic Acids Research. 41: 3240-56. PMID 23341039 DOI: 10.1093/nar/gks1227  1
2013 Cardenas-Aguayo Mdel C, Kazim SF, Grundke-Iqbal I, Iqbal K. Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures. Plos One. 8: e53596. PMID 23320097 DOI: 10.1371/journal.pone.0053596  1
2013 Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: similarities to and differences from the transgenic model (3xTg-AD mouse). Molecular Neurobiology. 47: 711-25. PMID 23150171 DOI: 10.1007/s12035-012-8375-5  1
2013 Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K. Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. Journal of Alzheimer's Disease : Jad. 33: S123-39. PMID 22710920 DOI: 10.3233/JAD-2012-129031  1
2012 Chen Y, Tian Z, Liang Z, Sun S, Dai CL, Lee MH, LaFerla FM, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Brain gene expression of a sporadic (icv-STZ Mouse) and a familial mouse model (3xTg-AD mouse) of Alzheimer's disease. Plos One. 7: e51432. PMID 23236499 DOI: 10.1371/journal.pone.0051432  1
2012 Gong CX, Liu F, Iqbal K. O-GlcNAc cycling modulates neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 109: 17319-20. PMID 23047690 DOI: 10.1073/pnas.1215395109  0.84
2012 Liu Y, Li X, Yu Y, Shi J, Liang Z, Run X, Li Y, Dai CL, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Developmental regulation of protein O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in mammalian brain. Plos One. 7: e43724. PMID 22928023 DOI: 10.1371/journal.pone.0043724  1
2012 Yin X, Jin N, Gu J, Shi J, Zhou J, Gong CX, Iqbal K, Grundke-Iqbal I, Liu F. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. The Journal of Biological Chemistry. 287: 30497-506. PMID 22767602 DOI: 10.1074/jbc.M112.355412  1
2012 Shi J, Wu S, Dai CL, Li Y, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX. Diverse regulation of AKT and GSK-3β by O-GlcNAcylation in various types of cells. Febs Letters. 586: 2443-50. PMID 22687243 DOI: 10.1016/j.febslet.2012.05.063  1
2012 Gu J, Shi J, Wu S, Jin N, Qian W, Zhou J, Iqbal IG, Iqbal K, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates 9G8-mediated alternative splicing of tau exon 10. Febs Letters. 586: 2239-44. PMID 22677170 DOI: 10.1016/j.febslet.2012.05.046  0.84
2012 Yu Y, Zhang L, Li X, Run X, Liang Z, Li Y, Liu Y, Lee MH, Grundke-Iqbal I, Iqbal K, Vocadlo DJ, Liu F, Gong CX. Differential effects of an O-GlcNAcase inhibitor on tau phosphorylation. Plos One. 7: e35277. PMID 22536363 DOI: 10.1371/journal.pone.0035277  1
2012 Bolognin S, Blanchard J, Wang X, Basurto-Islas G, Tung YC, Kohlbrenner E, Grundke-Iqbal I, Iqbal K. An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide. Acta Neuropathologica. 123: 133-51. PMID 22083255 DOI: 10.1007/s00401-011-0908-x  1
2012 Ding S, Shi J, Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A. Neurobiology of Aging. 33: 1389-99. PMID 21215488 DOI: 10.1016/j.neurobiolaging.2010.11.021  1
2011 Blanchard J, Bolognin S, Chohan MO, Rabe A, Iqbal K, Grundke-Iqbal I. Rescue of synaptic failure and alleviation of learning and memory impairments in a trisomic mouse model of down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 1070-9. PMID 22082658 DOI: 10.1097/NEN.0b013e318236e9ad  1
2011 Iqbal K, Grundke-Iqbal I. Opportunities and challenges in developing Alzheimer disease therapeutics. Acta Neuropathologica. 122: 543-9. PMID 21959585 DOI: 10.1007/s00401-011-0878-z  1
2011 Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice. Journal of Alzheimer's Disease : Jad. 27: 743-52. PMID 21860085 DOI: 10.3233/JAD-2011-110914  1
2011 Arnaud L, Chen S, Liu F, Li B, Khatoon S, Grundke-Iqbal I, Iqbal K. Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET. Febs Letters. 585: 2653-9. PMID 21806989 DOI: 10.1016/j.febslet.2011.07.020  1
2011 Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Iqbal K, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/j.jalz.2011.05.2243  1
2011 Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes. The Journal of Pathology. 225: 54-62. PMID 21598254 DOI: 10.1002/path.2912  1
2011 Chalbot S, Zetterberg H, Blennow K, Fladby T, Andreasen N, Grundke-Iqbal I, Iqbal K. Blood-cerebrospinal fluid barrier permeability in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 25: 505-15. PMID 21471645 DOI: 10.3233/JAD-2011-101959  1
2011 Qian W, Liang H, Shi J, Jin N, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Regulation of the alternative splicing of tau exon 10 by SC35 and Dyrk1A. Nucleic Acids Research. 39: 6161-71. PMID 21470964 DOI: 10.1093/nar/gkr195  1
2011 Shi J, Qian W, Yin X, Iqbal K, Grundke-Iqbal I, Gu X, Ding F, Gong CX, Liu F. Cyclic AMP-dependent protein kinase regulates the alternative splicing of tau exon 10: a mechanism involved in tau pathology of Alzheimer disease. The Journal of Biological Chemistry. 286: 14639-48. PMID 21367856 DOI: 10.1074/jbc.M110.204453  1
2011 Qian W, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Splicing factor SC35 promotes tau expression through stabilization of its mRNA. Febs Letters. 585: 875-80. PMID 21333649 DOI: 10.1016/j.febslet.2011.02.017  1
2011 Wegiel J, Kaczmarski W, Barua M, Kuchna I, Nowicki K, Wang KC, Wegiel J, Yang SM, Frackowiak J, Mazur-Kolecka B, Silverman WP, Reisberg B, Monteiro I, de Leon M, Wisniewski T, ... ... Iqbal K, et al. Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome. Journal of Neuropathology and Experimental Neurology. 70: 36-50. PMID 21157379 DOI: 10.1097/NEN.0b013e318202bfa1  1
2011 Qian W, Yin X, Hu W, Shi J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX, Liu F. Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 23: 617-27. PMID 21157033 DOI: 10.3233/JAD-2010-100987  1
2011 Chohan MO, Li B, Blanchard J, Tung YC, Heaney AT, Rabe A, Iqbal K, Grundke-Iqbal I. Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide. Neurobiology of Aging. 32: 1420-34. PMID 19767127 DOI: 10.1016/j.neurobiolaging.2009.08.008  1
2010 Blanchard J, Chohan MO, Li B, Liu F, Iqbal K, Grundke-Iqbal I. Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis, neuronal plasticity, and spatial memory in mice. Journal of Alzheimer's Disease : Jad. 21: 1185-95. PMID 20952820 DOI: 10.3233/JAD-2010-1000069  1
2010 Iqbal K, Grundke-Iqbal I. Alzheimer's disease, a multifactorial disorder seeking multitherapies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 420-4. PMID 20813343 DOI: 10.1016/j.jalz.2010.04.006  1
2010 Blanchard J, Wanka L, Tung YC, Cárdenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I. Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice. Acta Neuropathologica. 120: 605-21. PMID 20697724 DOI: 10.1007/s00401-010-0734-6  1
2010 Iqbal K, Liu F, Gong CX, Grundke-Iqbal I. Tau in Alzheimer disease and related tauopathies. Current Alzheimer Research. 7: 656-64. PMID 20678074  1
2010 Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K. Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. The Journal of Biological Chemistry. 285: 30851-60. PMID 20663882 DOI: 10.1074/jbc.M110.110957  1
2010 Iqbal K, Wang X, Blanchard J, Liu F, Gong CX, Grundke-Iqbal I. Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial. Biochemical Society Transactions. 38: 962-6. PMID 20658985 DOI: 10.1042/BST0380962  1
2010 Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K. The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4420-32. PMID 20651003 DOI: 10.1096/fj.10-158477  1
2010 Li B, Wanka L, Blanchard J, Liu F, Chohan MO, Iqbal K, Grundke-Iqbal I. Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice. Febs Letters. 584: 3359-65. PMID 20600002 DOI: 10.1016/j.febslet.2010.06.025  1
2010 Chalbot S, Zetterberg H, Blennow K, Fladby T, Grundke-Iqbal I, Iqbal K. Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity: a biomarker of blood-cerebrospinal fluid barrier permeability. Neuroscience Letters. 478: 179-83. PMID 20470866 DOI: 10.1016/j.neulet.2010.05.012  1
2010 Gong CX, Grundke-Iqbal I, Iqbal K. Targeting tau protein in Alzheimer's disease. Drugs & Aging. 27: 351-65. PMID 20450234 DOI: 10.2165/11536110-000000000-00000  1
2010 Zilka N, Korenova M, Kovacech B, Iqbal K, Novak M. CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy. Acta Neuropathologica. 119: 679-87. PMID 20379729 DOI: 10.1007/s00401-010-0680-3  0.52
2010 Qian W, Shi J, Yin X, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta. Journal of Alzheimer's Disease : Jad. 19: 1221-9. PMID 20308788 DOI: 10.3233/JAD-2010-1317  1
2009 Chalbot S, Zetterberg H, Blennow K, Fladby T, Grundke-Iqbal I, Iqbal K. Cerebrospinal fluid secretory Ca2+-dependent phospholipase A2 activity is increased in Alzheimer disease. Clinical Chemistry. 55: 2171-9. PMID 19850632 DOI: 10.1373/clinchem.2009.130286  1
2009 Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer's disease. The American Journal of Pathology. 175: 2089-98. PMID 19815707 DOI: 10.2353/ajpath.2009.090157  1
2009 Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Brain glucose transporters, O-GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer's disease. Journal of Neurochemistry. 111: 242-9. PMID 19659459 DOI: 10.1111/j.1471-4159.2009.06320.x  1
2009 Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M. Novel therapeutic strategies for neurodegenerative disease. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society. 9: 103-9. PMID 19604333 DOI: 10.1111/j.1479-8301.2009.00289.x  1
2009 Liu F, Shi J, Tanimukai H, Gu J, Gu J, Grundke-Iqbal I, Iqbal K, Gong CX. Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease. Brain : a Journal of Neurology. 132: 1820-32. PMID 19451179 DOI: 10.1093/brain/awp099  1
2009 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Dysregulation of tau phosphorylation in mouse brain during excitotoxic damage. Journal of Alzheimer's Disease : Jad. 17: 531-9. PMID 19363259 DOI: 10.3233/JAD-2009-1069  1
2009 Run X, Liang Z, Zhang L, Iqbal K, Grundke-Iqbal I, Gong CX. Anesthesia induces phosphorylation of tau. Journal of Alzheimer's Disease : Jad. 16: 619-26. PMID 19276556 DOI: 10.3233/JAD-2009-1003  1
2009 Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I. Mechanisms of tau-induced neurodegeneration. Acta Neuropathologica. 118: 53-69. PMID 19184068 DOI: 10.1007/s00401-009-0486-3  1
2009 Yu Y, Run X, Liang Z, Li Y, Liu F, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX. Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases. Journal of Neurochemistry. 108: 1480-94. PMID 19183272 DOI: 10.1111/j.1471-4159.2009.05882.x  1
2008 Iqbal K, Chohan MO, Grundke-Iqbal I. Stratification of patients is the way to go to develop neuroprotective/disease-modifying drugs for Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 15: 339-45. PMID 18953118  1
2008 Gong CX, Iqbal K. Hyperphosphorylation of microtubule-associated protein tau: a promising therapeutic target for Alzheimer disease. Current Medicinal Chemistry. 15: 2321-8. PMID 18855662  0.84
2008 Alonso AC, Li B, Grundke-Iqbal I, Iqbal K. Mechanism of tau-induced neurodegeneration in Alzheimer disease and related tauopathies. Current Alzheimer Research. 5: 375-84. PMID 18690834  1
2008 Iqbal K, Alonso Adel C, Grundke-Iqbal I. Cytosolic abnormally hyperphosphorylated tau but not paired helical filaments sequester normal MAPs and inhibit microtubule assembly. Journal of Alzheimer's Disease : Jad. 14: 365-70. PMID 18688085  1
2008 Shi J, Zhang T, Zhou C, Chohan MO, Gu X, Wegiel J, Zhou J, Hwang YW, Iqbal K, Grundke-Iqbal I, Gong CX, Liu F. Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome. The Journal of Biological Chemistry. 283: 28660-9. PMID 18658135 DOI: 10.1074/jbc.M802645200  1
2008 Liu F, Liang Z, Wegiel J, Hwang YW, Iqbal K, Grundke-Iqbal I, Ramakrishna N, Gong CX. Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3224-33. PMID 18509201 DOI: 10.1096/fj.07-104539  1
2008 Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Wegiel J, Gong CX. Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. Journal of Alzheimer's Disease : Jad. 13: 295-302. PMID 18430997  1
2008 Chen S, Li B, Grundke-Iqbal I, Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. The Journal of Biological Chemistry. 283: 10513-21. PMID 18245083 DOI: 10.1074/jbc.M709852200  1
2008 Wang XC, Zhang YC, Chatterjie N, Grundke-Iqbal I, Iqbal K, Wang JZ. Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells. Neurochemical Research. 33: 1138-44. PMID 18231852 DOI: 10.1007/s11064-007-9563-y  1
2008 Iqbal K, Grundke-Iqbal I. Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention. Journal of Cellular and Molecular Medicine. 12: 38-55. PMID 18194444 DOI: 10.1111/j.1582-4934.2008.00225.x  1
2008 Liu Y, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. Febs Letters. 582: 359-64. PMID 18174027 DOI: 10.1016/j.febslet.2007.12.035  1
2008 Li B, Yamamori H, Tatebayashi Y, Shafit-Zagardo B, Tanimukai H, Chen S, Iqbal K, Grundke-Iqbal I. Failure of neuronal maturation in Alzheimer disease dentate gyrus. Journal of Neuropathology and Experimental Neurology. 67: 78-84. PMID 18091557 DOI: 10.1097/nen.0b013e318160c5db  1
2008 Deng Y, Li B, Liu F, Iqbal K, Grundke-Iqbal I, Brandt R, Gong CX. Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 138-45. PMID 17687114 DOI: 10.1096/fj.07-8309com  1
2007 Sevcik J, Skrabana R, Dvorsky R, Csokova N, Iqbal K, Novak M. X-ray structure of the PHF core C-terminus: insight into the folding of the intrinsically disordered protein tau in Alzheimer's disease. Febs Letters. 581: 5872-8. PMID 18061582 DOI: 10.1016/j.febslet.2007.11.067  0.52
2007 Liu F, Li B, Tung EJ, Grundke-Iqbal I, Iqbal K, Gong CX. Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. The European Journal of Neuroscience. 26: 3429-36. PMID 18052981 DOI: 10.1111/j.1460-9568.2007.05955.x  1
2007 Liang Z, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. Journal of Neurochemistry. 103: 2462-70. PMID 17908236 DOI: 10.1111/j.1471-4159.2007.04942.x  1
2007 Iqbal K, Chu Q, Mei Q, Chen Y. Bevacizumab-associated reversible hypotension. Clinical Oncology (Royal College of Radiologists (Great Britain)). 19: 800-1. PMID 17825542 DOI: 10.1016/j.clon.2007.08.002  0.44
2007 Iqbal K, Grundke-Iqbal I. Developing pharmacological therapies for Alzheimer disease. Cellular and Molecular Life Sciences : Cmls. 64: 2234-44. PMID 17604997 DOI: 10.1007/s00018-007-7221-9  1
2007 Yamamori H, Khatoon S, Grundke-Iqbal I, Blennow K, Ewers M, Hampel H, Iqbal K. Tau in cerebrospinal fluid: a sensitive sandwich enzyme-linked immunosorbent assay using tyramide signal amplification. Neuroscience Letters. 418: 186-9. PMID 17400380 DOI: 10.1016/j.neulet.2007.03.022  1
2007 Li B, Chohan MO, Grundke-Iqbal I, Iqbal K. Disruption of microtubule network by Alzheimer abnormally hyperphosphorylated tau. Acta Neuropathologica. 113: 501-11. PMID 17372746 DOI: 10.1007/s00401-007-0207-8  1
2007 Kovacech B, Kontsekova E, Zilka N, Novak P, Skrabana R, Filipcik P, Iqbal K, Novak M. A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain. Febs Letters. 581: 617-22. PMID 17266954 DOI: 10.1016/j.febslet.2007.01.015  0.52
2007 Wang JZ, Grundke-Iqbal I, Iqbal K. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. The European Journal of Neuroscience. 25: 59-68. PMID 17241267 DOI: 10.1111/j.1460-9568.2006.05226.x  1
2007 Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I. Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiology of Aging. 28: 1148-62. PMID 16859812 DOI: 10.1016/j.neurobiolaging.2006.05.036  1
2006 Grundke-Iqbal I, Rolkova G, Konstekova E, Iqbal K. Biological markers in Alzheimer's disease. Bratislavské LekáRske Listy. 107: 359-65. PMID 17262988  1
2006 Pevalova M, Filipcik P, Novak M, Avila J, Iqbal K. Post-translational modifications of tau protein. Bratislavské LekáRske Listy. 107: 346-53. PMID 17262986  0.76
2006 Iqbal K, Novak M. From tangles to tau protein. Bratislavské LekáRske Listy. 107: 341-2. PMID 17262984  1
2006 Sengupta A, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of tau by protein kinases in rat brain. Neurochemical Research. 31: 1473-80. PMID 17120162 DOI: 10.1007/s11064-006-9205-9  1
2006 Liu F, Liang Z, Shi J, Yin D, El-Akkad E, Grundke-Iqbal I, Iqbal K, Gong CX. PKA modulates GSK-3beta- and cdk5-catalyzed phosphorylation of tau in site- and kinase-specific manners. Febs Letters. 580: 6269-74. PMID 17078951 DOI: 10.1016/j.febslet.2006.10.033  1
2006 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Dysregulation of protein phosphorylation/dephosphorylation in Alzheimer's disease: a therapeutic target. Journal of Biomedicine & Biotechnology. 2006: 31825. PMID 17047304 DOI: 10.1155/JBB/2006/31825  1
2006 Sengupta A, Novak M, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level. Febs Letters. 580: 5925-33. PMID 17045592 DOI: 10.1016/j.febslet.2006.09.060  1
2006 Chohan MO, Iqbal K. From tau to toxicity: emerging roles of NMDA receptor in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 10: 81-7. PMID 16988485  1
2006 Iqbal K, Grundke-Iqbal I. Discoveries of tau, abnormally hyperphosphorylated tau and others of neurofibrillary degeneration: a personal historical perspective. Journal of Alzheimer's Disease : Jad. 9: 219-42. PMID 16914861  1
2006 Chohan MO, Khatoon S, Iqbal IG, Iqbal K. Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. Febs Letters. 580: 3973-9. PMID 16806196 DOI: 10.1016/j.febslet.2006.06.021  0.72
2006 Alonso Adel C, Li B, Grundke-Iqbal I, Iqbal K. Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proceedings of the National Academy of Sciences of the United States of America. 103: 8864-9. PMID 16735465 DOI: 10.1073/pnas.0603214103  1
2006 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Impaired brain glucose metabolism leads to Alzheimer neurofibrillary degeneration through a decrease in tau O-GlcNAcylation. Journal of Alzheimer's Disease : Jad. 9: 1-12. PMID 16627930  1
2006 Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ. Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiology of Disease. 22: 657-68. PMID 16513361 DOI: 10.1016/j.nbd.2006.01.006  1
2006 Rahman A, Grundke-Iqbal I, Iqbal K. PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 219-30. PMID 15959850 DOI: 10.1007/s00702-005-0313-5  1
2005 del C Alonso A, Iqbal K. Tau-induced neurodegeneration: a clue to its mechanism. Journal of Alzheimer's Disease : Jad. 8: 223-6. PMID 16340080  1
2005 Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. The European Journal of Neuroscience. 22: 1942-50. PMID 16262633 DOI: 10.1111/j.1460-9568.2005.04391.x  1
2005 Iqbal K, Flory M, Khatoon S, Soininen H, Pirttila T, Lehtovirta M, Alafuzoff I, Blennow K, Andreasen N, Vanmechelen E, Grundke-Iqbal I. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Annals of Neurology. 58: 748-57. PMID 16247771 DOI: 10.1002/ana.20639  1
2005 Wiltfang J, Lewczuk P, Riederer P, Grünblatt E, Hock C, Scheltens P, Hampel H, Vanderstichele H, Iqbal K, Galasko D, Lannfelt L, Otto M, Esselmann H, Henkel AW, Kornhuber J, et al. Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 6: 69-84. PMID 16156480 DOI: 10.1080/15622970510029786  1
2005 Liu F, Grundke-Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong CX. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. The Journal of Biological Chemistry. 280: 37755-62. PMID 16150694 DOI: 10.1074/jbc.M507475200  1
2005 Ruben GC, Wang JZ, Iqbal K, Grundke-Iqbal I. Paired helical filaments (PHFs) are a family of single filament structures with a common helical turn period: negatively stained PHF imaged by TEM and measured before and after sonication, deglycosylation, and dephosphorylation. Microscopy Research and Technique. 67: 175-95. PMID 16104003 DOI: 10.1002/jemt.20197  1
2005 Ruben GC, Novak M, Edwards PC, Iqbal K. Alzheimer paired helical filaments (PHFs) studied by high-resolution TEM: what can vertical Pt-C replication tell us about the organization of the pronase-digested PHF core? Microscopy Research and Technique. 67: 196-209. PMID 16103996 DOI: 10.1002/jemt.20198  1
2005 Ashford JW, Atwood CS, Blass JP, Bowen RL, Finch CE, Iqbal K, Joseph JA, Perry G. What is aging? What is its role in Alzheimer's disease? What can we do about it? Journal of Alzheimer's Disease : Jad. 7: 247-53; discussion 2. PMID 16006669  1
2005 Iqbal K, Grundke-Iqbal I. Pharmacological approaches of neurofibrillary degeneration. Current Alzheimer Research. 2: 335-41. PMID 15974899 DOI: 10.2174/1567205054367810  1
2005 Tanimukai H, Grundke-Iqbal I, Iqbal K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. The American Journal of Pathology. 166: 1761-71. PMID 15920161 DOI: 10.1016/S0002-9440(10)62486-8  1
2005 Rahman A, Grundke-Iqbal I, Iqbal K. Phosphothreonine-212 of Alzheimer abnormally hyperphosphorylated tau is a preferred substrate of protein phosphatase-1. Neurochemical Research. 30: 277-87. PMID 15895832 DOI: 10.1007/s11064-005-2483-9  1
2005 Iqbal K, Grundke-Iqbal I. Metabolic/signal transduction hypothesis of Alzheimer's disease and other tauopathies. Acta Neuropathologica. 109: 25-31. PMID 15645264 DOI: 10.1007/s00401-004-0951-y  1
2005 Tsujio I, Zaidi T, Xu J, Kotula L, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A from human brain structures, immunocytological localization and activities towards dephosphorylation of the Alzheimer type hyperphosphorylated tau. Febs Letters. 579: 363-72. PMID 15642345 DOI: 10.1016/j.febslet.2004.11.097  1
2005 Sun L, Wang X, Liu S, Wang Q, Wang J, Bennecib M, Gong CX, Sengupta A, Grundke-Iqbal I, Iqbal K. Bilateral injection of isoproterenol into hippocampus induces Alzheimer-like hyperphosphorylation of tau and spatial memory deficit in rat. Febs Letters. 579: 251-8. PMID 15620722 DOI: 10.1016/j.febslet.2004.11.083  1
2005 Iqbal K, Alonso Adel C, Chen S, Chohan MO, El-Akkad E, Gong CX, Khatoon S, Li B, Liu F, Rahman A, Tanimukai H, Grundke-Iqbal I. Tau pathology in Alzheimer disease and other tauopathies. Biochimica Et Biophysica Acta. 1739: 198-210. PMID 15615638 DOI: 10.1016/j.bbadis.2004.09.008  1
2005 Chohan MO, Haque N, Alonso A, El-Akkad E, Grundke-Iqbal I, Grover A, Iqbal K. Hyperphosphorylation-induced self assembly of murine tau: a comparison with human tau. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1035-47. PMID 15583961 DOI: 10.1007/s00702-004-0241-9  1
2005 Huang Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX. NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain. Neuroscience Letters. 373: 115-8. PMID 15567564 DOI: 10.1016/j.neulet.2004.09.074  1
2005 Liu F, Iqbal K, Grundke-Iqbal I, Rossie S, Gong CX. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. The Journal of Biological Chemistry. 280: 1790-6. PMID 15546861 DOI: 10.1074/jbc.M410775200  1
2005 Gong CX, Liu F, Grundke-Iqbal I, Iqbal K. Post-translational modifications of tau protein in Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 813-38. PMID 15517432 DOI: 10.1007/s00702-004-0221-0  1
2004 Huang Y, Tanimukai H, Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Elevation of the level and activity of acid ceramidase in Alzheimer's disease brain. The European Journal of Neuroscience. 20: 3489-97. PMID 15610181 DOI: 10.1111/j.1460-9568.2004.03852.x  1
2004 Haque N, Gong CX, Sengupta A, Iqbal K, Grundke-Iqbal I. Regulation of microtubule-associated proteins, protein kinases and protein phosphatases during differentiation of SY5Y cells. Brain Research. Molecular Brain Research. 129: 163-70. PMID 15469892 DOI: 10.1016/j.molbrainres.2004.07.001  1
2004 Liu SJ, Zhang JY, Li HL, Fang ZY, Wang Q, Deng HM, Gong CX, Grundke-Iqbal I, Iqbal K, Wang JZ. Tau becomes a more favorable substrate for GSK-3 when it is prephosphorylated by PKA in rat brain. The Journal of Biological Chemistry. 279: 50078-88. PMID 15375165 DOI: 10.1074/jbc.M406109200  1
2004 Iqbal K, Grundke-Iqbal I. Inhibition of neurofibrillary degeneration: a promising approach to Alzheimer's disease and other tauopathies. Current Drug Targets. 5: 495-502. PMID 15270196 DOI: 10.2174/1389450043345254  1
2004 Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 10804-9. PMID 15249677 DOI: 10.1073/pnas.0400348101  1
2004 Tanimukai H, Grundke-Iqbal I, Iqbal K. Inhibitors of protein phosphatase-2A: topography and subcellular localization. Brain Research. Molecular Brain Research. 126: 146-56. PMID 15249138 DOI: 10.1016/j.molbrainres.2004.04.003  1
2004 Skrabana R, Kontsek P, Mederlyova A, Iqbal K, Novak M. Folding of Alzheimer's core PHF subunit revealed by monoclonal antibody 423. Febs Letters. 568: 178-82. PMID 15196943 DOI: 10.1016/j.febslet.2004.04.098  0.52
2004 Alonso Adel C, Mederlyova A, Novak M, Grundke-Iqbal I, Iqbal K. Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. The Journal of Biological Chemistry. 279: 34873-81. PMID 15190058 DOI: 10.1074/jbc.M405131200  1
2004 Li L, Sengupta A, Haque N, Grundke-Iqbal I, Iqbal K. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. Febs Letters. 566: 261-9. PMID 15147906 DOI: 10.1016/j.febslet.2004.04.047  1
2004 Tatebayashi Y, Haque N, Tung YC, Iqbal K, Grundke-Iqbal I. Role of tau phosphorylation by glycogen synthase kinase-3beta in the regulation of organelle transport. Journal of Cell Science. 117: 1653-63. PMID 15075227 DOI: 10.1242/jcs.01018  1
2004 Gong CX, Liu F, Wu G, Rossie S, Wegiel J, Li L, Grundke-Iqbal I, Iqbal K. Dephosphorylation of microtubule-associated protein tau by protein phosphatase 5. Journal of Neurochemistry. 88: 298-310. PMID 14690518  1
2003 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tanimukai H, Tsujio I, Wang JZ, Grundke-Iqba I. Alzheimer neurofibrillary degeneration: therapeutic targets and high-throughput assays. Journal of Molecular Neuroscience : Mn. 20: 425-9. PMID 14501027  0.84
2003 Pei JJ, Gong CX, An WL, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease. The American Journal of Pathology. 163: 845-58. PMID 12937126 DOI: 10.1016/S0002-9440(10)63445-1  1
2003 An WL, Cowburn RF, Li L, Braak H, Alafuzoff I, Iqbal K, Iqbal IG, Winblad B, Pei JJ. Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease. The American Journal of Pathology. 163: 591-607. PMID 12875979 DOI: 10.1016/S0002-9440(10)63687-5  1
2003 Hua Q, He RQ, Haque N, Qu MH, del Carmen Alonso A, Grundke-Iqbal I, Iqbal K. Microtubule associated protein tau binds to double-stranded but not single-stranded DNA. Cellular and Molecular Life Sciences : Cmls. 60: 413-21. PMID 12678504  1
2003 Gong CX, Wang JZ, Iqbal K, Grundke-Iqbal I. Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neuroscience Letters. 340: 107-10. PMID 12668248  1
2003 Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K. Role of protein kinase B in Alzheimer's neurofibrillary pathology. Acta Neuropathologica. 105: 381-92. PMID 12624792 DOI: 10.1007/s00401-002-0657-y  1
2003 Tatebayashi Y, Lee MH, Li L, Iqbal K, Grundke-Iqbal I. The dentate gyrus neurogenesis: a therapeutic target for Alzheimer's disease. Acta Neuropathologica. 105: 225-32. PMID 12557008 DOI: 10.1007/s00401-002-0636-3  1
2002 Wang J, Wang X, Liu R, Wang Q, Grundke-Iqbal I, Iqbal K. In vitro analysis of tau phosphorylation sites and its biological activity. Chinese Medical Sciences Journal = Chung-Kuo I HsüEh K'O HsüEh Tsa Chih / Chinese Academy of Medical Sciences. 17: 13-6. PMID 12894878  1
2002 Pei JJ, Braak H, An WL, Winblad B, Cowburn RF, Iqbal K, Grundke-Iqbal I. Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease. Brain Research. Molecular Brain Research. 109: 45-55. PMID 12531514 DOI: 10.1016/S0169-328X(02)00488-6  1
2002 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Tsujio I, Grundke-Iqbal I. Pharmacological targets to inhibit Alzheimer neurofibrillary degeneration. Journal of Neural Transmission. Supplementum. 309-19. PMID 12456074  1
2002 Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Gong CX. Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5. Neuroscience. 115: 829-37. PMID 12435421  1
2002 Liu F, Iqbal K, Grundke-Iqbal I, Gong CX. Involvement of aberrant glycosylation in phosphorylation of tau by cdk5 and GSK-3beta. Febs Letters. 530: 209-14. PMID 12387894  1
2002 Iqbal K, Grundke-Iqbal I. Neurofibrillary pathology leads to synaptic loss and not the other way around in Alzheimer disease. Journal of Alzheimer's Disease : Jad. 4: 235-8. PMID 12226542  1
2002 Iqbal K, Alonso Adel C, El-Akkad E, Gong CX, Haque N, Khatoon S, Pei JJ, Tsujio I, Wang JZ, Grundke-Iqbal I. Significance and mechanism of Alzheimer neurofibrillary degeneration and therapeutic targets to inhibit this lesion. Journal of Molecular Neuroscience : Mn. 19: 95-9. PMID 12212801  1
2002 Pei JJ, Braak H, Gong CX, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Up-regulation of cell division cycle (cdc) 2 kinase in neurons with early stage Alzheimer's disease neurofibrillary degeneration. Acta Neuropathologica. 104: 369-76. PMID 12200623 DOI: 10.1007/s00401-002-0565-1  1
2002 Hu YY, He SS, Wang X, Duan QH, Grundke-Iqbal I, Iqbal K, Wang J. Levels of nonphosphorylated and phosphorylated tau in cerebrospinal fluid of Alzheimer's disease patients : an ultrasensitive bienzyme-substrate-recycle enzyme-linked immunosorbent assay. The American Journal of Pathology. 160: 1269-78. PMID 11943712 DOI: 10.1016/S0002-9440(10)62554-0  1
2002 Hu YY, He SS, Wang XC, Duan QH, Khatoon S, Iqbal K, Grundke-Iqbal I, Wang JZ. Elevated levels of phosphorylated neurofilament proteins in cerebrospinal fluid of Alzheimer disease patients. Neuroscience Letters. 320: 156-60. PMID 11852185  1
2002 Liu F, Zaidi T, Iqbal K, Grundke-Iqbal I, Merkle RK, Gong CX. Role of glycosylation in hyperphosphorylation of tau in Alzheimer's disease. Febs Letters. 512: 101-6. PMID 11852060  1
2001 Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF. Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration. Journal of Alzheimer's Disease : Jad. 3: 41-48. PMID 12214071  1
2001 Vijayan S, El-Akkad E, Grundke-Iqbal I, Iqbal K. A pool of beta-tubulin is hyperphosphorylated at serine residues in Alzheimer disease brain. Febs Letters. 509: 375-81. PMID 11749959  1
2001 Wang J, Tung YC, Wang Y, Li XT, Iqbal K, Grundke-Iqbal I. Hyperphosphorylation and accumulation of neurofilament proteins in Alzheimer disease brain and in okadaic acid-treated SY5Y cells. Febs Letters. 507: 81-7. PMID 11682063  1
2001 Alonso AD, Zaidi T, Novak M, Barra HS, Grundke-Iqbal I, Iqbal K. Interaction of tau isoforms with Alzheimer's disease abnormally hyperphosphorylated tau and in vitro phosphorylation into the disease-like protein. The Journal of Biological Chemistry. 276: 37967-73. PMID 11495914 DOI: 10.1074/jbc.M105365200  1
2001 Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue nonbinding phosphatase activities. Neurochemical Research. 26: 425-38. PMID 11495355  1
2001 Alonso A, Zaidi T, Novak M, Grundke-Iqbal I, Iqbal K. Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments. Proceedings of the National Academy of Sciences of the United States of America. 98: 6923-8. PMID 11381127 DOI: 10.1073/pnas.121119298  1
2001 Sato Y, Naito Y, Grundke-Iqbal I, Iqbal K, Endo T. Analysis of N-glycans of pathological tau: possible occurrence of aberrant processing of tau in Alzheimer's disease. Febs Letters. 496: 152-60. PMID 11356201  1
2001 Gong CX, Lidsky T, Wegiel J, Grundke-Iqbal I, Iqbal K. Metabolically active rat brain slices as a model to study the regulation of protein phosphorylation in mammalian brain. Brain Research. Brain Research Protocols. 6: 134-40. PMID 11223412 DOI: 10.1016/S1385-299X(00)00046-5  1
2001 Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356. Febs Letters. 490: 15-22. PMID 11172803  1
2000 Wang J, Wei Z, Wang Q, Grundke-Iqbal I, Iqbal K. [Association of microtubule promoting and binding activity of tau with its phosphorylation sites]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 22: 120-3. PMID 12903511  1
2000 Iqbal K, Grundke-Iqbal I. Alzheimer disease is multifactorial and heterogeneous. Neurobiology of Aging. 21: 901-2; discussion 90. PMID 11124439 DOI: 10.1016/S0197-4580(00)00191-3  1
2000 Bennecib M, Gong CX, Grundke-Iqbal I, Iqbal K. Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain. Febs Letters. 485: 87-93. PMID 11086171  1
2000 Iqbal K, Alonso AD, Gondal JA, Gong CX, Haque N, Khatoon S, Sengupta A, Wang JZ, Grundke-Iqbal I. Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. Journal of Neural Transmission. Supplementum. 59: 213-22. PMID 10961432  1
2000 Tsujio I, Tanaka T, Kudo T, Nishikawa T, Shinozaki K, Grundke-Iqbal I, Iqbal K, Takeda M. Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. Febs Letters. 469: 111-7. PMID 10708767  1
2000 Cheng LY, Wang JZ, Gong CX, Pei JJ, Zaidi T, Grundke-Iqbal I, Iqbal K. Multiple forms of phosphatase from human brain: isolation and partial characterization of affi-gel blue binding phosphatases. Neurochemical Research. 25: 107-20. PMID 10685610  1
2000 Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. The Journal of Biological Chemistry. 275: 5535-44. PMID 10681533 DOI: 10.1074/jbc.275.8.5535  1
2000 Gong CX, Wegiel J, Lidsky T, Zuck L, Avila J, Wisniewski HM, Grundke-Iqbal I, Iqbal K. Regulation of phosphorylation of neuronal microtubule-associated proteins MAP1b and MAP2 by protein phosphatase-2A and -2B in rat brain. Brain Research. 853: 299-309. PMID 10640627 DOI: 10.1016/S0006-8993(99)02294-5  1
1999 Grundke-Iqbal I, Iqbal K. Tau pathology generated by overexpression of tau. The American Journal of Pathology. 155: 1781-5. PMID 10595905 DOI: 10.1016/S0002-9440(10)65494-6  1
1998 Iqbal K, Grundke-Iqbal I. Tau phosphatase activity as a therapeutic target for AD. Drug News & Perspectives. 11: 10-4. PMID 15616638  1
1974 Iqbal K, Wi?niewski HM, Shelanski ML, Brostoff S, Liwnicz BH, Terry RD. Protein changes in senile dementia. Brain Research. 77: 337-43. PMID 4604978 DOI: 10.1016/0006-8993(74)90798-7  1
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