Ian R. MacKenzie - Publications

Pathology Vancouver General Hospital, Vancouver, British Columbia, Canada 

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lee S, Jiang K, McIlmoyle B, To E, Xu QA, Hirsch-Reinshagen V, Mackenzie IR, Hsiung GR, Eadie BD, Sarunic MV, Beg MF, Cui JZ, Matsubara JA. Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer's Eye. Frontiers in Neuroscience. 14: 758. PMID 32848548 DOI: 10.3389/Fnins.2020.00758  0.331
2020 Neumann M, Frick P, Paron F, Kosten J, Buratti E, Mackenzie IR. Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD-TDP subtypes. Acta Neuropathologica. 140: 645-658. PMID 32778941 DOI: 10.1007/S00401-020-02207-W  0.357
2020 Gentry MT, Lapid MI, Syrjanen J, Calvert K, Hughes S, Brushaber D, Kremers W, Bove J, Brannelly P, Coppola G, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, ... ... Mackenzie I, et al. Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32656921 DOI: 10.1002/Alz.12095  0.326
2020 Chornenka K, Hirsch-Reinshagen V, Perez-Rosendahl M, Feldman H, Segal-Gidan F, Vinters HV, Mackenzie IR. Expanding the Phenotype of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FUS). Journal of Neuropathology and Experimental Neurology. PMID 32483606 DOI: 10.1093/Jnen/Nlaa045  0.374
2020 Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Molecular Neurodegeneration. 15: 21. PMID 32178712 DOI: 10.1186/S13024-020-00369-5  0.368
2020 Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, ... ... Mackenzie IR, et al. Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 11-21. PMID 31914230 DOI: 10.1016/J.Jalz.2019.01.012  0.347
2020 Heuer HW, Wang P, Rascovsky K, Wolf A, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber DE, Caso C, Coppola G, Dickerson B, Dickinson S, Domoto-Reilly K, Faber K, ... ... Mackenzie IR, et al. Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 60-70. PMID 31914226 DOI: 10.1002/Alz.12046  0.38
2020 Ramos EM, Dokuru DR, Van Berlo V, Wojta K, Wang Q, Huang AY, Deverasetty S, Qin Y, van Blitterswijk M, Jackson J, Appleby B, Bordelon Y, Brannelly P, Brushaber DE, Dickerson B, ... ... Mackenzie I, et al. Genetic screening of a large series of North American sporadic and familial frontotemporal dementia cases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 118-130. PMID 31914217 DOI: 10.1002/Alz.12011  0.364
2019 Moore KM, Nicholas J, Grossman M, McMillan CT, Irwin DJ, Massimo L, Van Deerlin VM, Warren JD, Fox NC, Rossor MN, Mead S, Bocchetta M, Boeve BF, Knopman DS, Graff-Radford NR, ... ... Mackenzie IR, et al. Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study. The Lancet. Neurology. PMID 31810826 DOI: 10.1016/S1474-4422(19)30394-1  0.37
2019 Olney NT, Ong E, Goh SM, Bajorek L, Dever R, Staffaroni AM, Cobigo Y, Bock M, Chiang K, Ljubenkov P, Kornak J, Heuer HW, Wang P, Rascovsky K, Wolf A, ... ... Mackenzie IR, et al. Clinical and volumetric changes with increasing functional impairment in familial frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31784375 DOI: 10.1016/J.Jalz.2019.08.196  0.38
2019 Boeve B, Bove J, Brannelly P, Brushaber D, Coppola G, Dever R, Dheel C, Dickerson B, Dickinson S, Faber K, Fields J, Fong J, Foroud T, Forsberg L, Gavrilova R, ... ... Mackenzie I, et al. The longitudinal evaluation of familial frontotemporal dementia subjects protocol: Framework and methodology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31636026 DOI: 10.1016/J.Jalz.2019.06.4947  0.329
2019 Chertkow H, Borrie M, Whitehead V, Black SE, Feldman HH, Gauthier S, Hogan DB, Masellis M, McGilton K, Rockwood K, Tierney MC, Andrew M, Hsiung GR, Camicioli R, Smith EE, ... ... MacKenzie I, et al. The Comprehensive Assessment of Neurodegeneration and Dementia: Canadian Cohort Study. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 1-13. PMID 31309917 DOI: 10.1017/Cjn.2019.27  0.333
2019 Staffaroni AM, Cobigo Y, Goh SM, Kornak J, Bajorek L, Chiang K, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dever R, Dheel C, ... ... Mackenzie IR, et al. Individualized atrophy scores predict dementia onset in familial frontotemporal lobar degeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31272932 DOI: 10.1016/J.Jalz.2019.04.007  0.306
2019 Hirsch-Reinshagen V, Alfaify OA, Hsiung GR, Pottier C, Baker M, Perkerson RB, Rademakers R, Briemberg H, Foti DJ, Mackenzie IR. Clinicopathologic correlations in a family with a mutation presenting as primary progressive aphasia and primary lateral sclerosis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 1-8. PMID 31244341 DOI: 10.1080/21678421.2019.1632347  0.409
2019 Chen Q, Boeve BF, Schwarz CG, Reid RI, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields JA, ... ... Mackenzie IR, et al. P2-329: Tracking White Matter Degeneration In Asymptomatic And Symptomatic Mapt Mutation Carriers With Dti Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2736  0.317
2019 Campbell MC, Ren J, Mason E, Redekop R, Kitor M, Emptage L, Hirsch-Reinshagen V, Robin Hsiung G, Mackenzie IR. P2-262: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY Alzheimer's & Dementia. 15: P685-P687. DOI: 10.1016/J.Jalz.2019.06.2669  0.325
2019 Chatterjee A, Hirsch-Reinshagen V, Ducharme B, Mousavi A, Mackenzie IR, Hsiung GR. P1-437: Comparison Of Clinical And Pathological Characteristics Of Patients With Ad, Dlb And Mixed Ad And Dlb Pathology Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.1042  0.335
2018 Popuri K, Dowds E, Beg MF, Balachandar R, Bhalla M, Jacova C, Buller A, Slack P, Sengdy P, Rademakers R, Wittenberg D, Feldman HH, Mackenzie IR, Hsiung GR. Gray matter changes in asymptomatic and mutation carriers. Neuroimage. Clinical. 18: 591-598. PMID 29845007 DOI: 10.1016/J.Nicl.2018.02.017  0.385
2018 Farrell M, Lichtenstein M, Crowley JJ, Filmyer DM, Lázaro-Muñoz G, Shaughnessy RA, Mackenzie IR, Hirsch-Reinshagen V, Stowe R, Evans JP, Berg JS, Szatkiewicz J, Josiassen RC, Sullivan PF. Developmental Delay, Treatment-Resistant Psychosis, and Early-Onset Dementia in a Man With 22q11 Deletion Syndrome and Huntington's Disease. The American Journal of Psychiatry. 175: 400-407. PMID 29712475 DOI: 10.1176/Appi.Ajp.2017.17060638  0.304
2018 Alexander C, Zeithamova D, Hsiung GR, Mackenzie IR, Jacova C. Decreased Prefrontal Activation during Matrix Reasoning in Predementia Progranulin Mutation Carriers. Journal of Alzheimer's Disease : Jad. 62: 583-589. PMID 29480174 DOI: 10.3233/Jad-170716  0.328
2018 Ukalovic K, Cao S, Lee S, Tang Q, Beg MF, Sarunic MV, Hsiung GR, Mackenzie IR, Hirsch-Reinshagen V, Cui JZ, Matsubara JA. Drusen in the Peripheral Retina of the Alzheimer's Eye. Current Alzheimer Research. PMID 29359670 DOI: 10.2174/1567205015666180123122637  0.32
2018 Touroutoglou A, Brickhouse M, Krivensky S, Wong B, Getchell K, Lucente D, McGinnis SM, Dickerson BC, Boeve BF, Rosen HJ, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, ... ... Mackenzie IR, et al. P1-419: Using A Brain Network Approach To Predict Genetic Mutation In Individual Patients With Familial Frontotemporal Dementia Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.428  0.359
2018 Staffaroni AM, Bajorek L, Ljubenkov P, Casaletto K, Elahi F, Rascovsky K, Boeve BF, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, Dickerson BC, Fields JA, Fong J, ... ... Mackenzie IR, et al. O1-08-01: The Nih-Examiner Is Sensitive To Cognitive Changes In Asymptomatic And Mildly Symptomatic Familial Frontotemporal Dementia Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2372  0.309
2017 Curtis AF, Masellis M, Hsiung GR, Moineddin R, Zhang K, Au B, Millett G, Mackenzie I, Rogaeva E, Tierney MC. Sex differences in the prevalence of genetic mutations in FTD and ALS: A meta-analysis. Neurology. PMID 28916533 DOI: 10.1212/Wnl.0000000000004494  0.385
2017 Pokrishevsky E, Hong RH, Mackenzie IR, Cashman NR. Spinal cord homogenates from SOD1 familial amyotrophic lateral sclerosis induce SOD1 aggregation in living cells. Plos One. 12: e0184384. PMID 28877271 DOI: 10.1371/Journal.Pone.0184384  0.308
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  0.395
2017 Mackenzie IR, Neumann M. Reappraisal of TDP-43 pathology in FTLD-U subtypes. Acta Neuropathologica. 134: 79-96. PMID 28466142 DOI: 10.1007/S00401-017-1716-8  0.341
2017 Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, ... ... Mackenzie IR, et al. Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis. Science Translational Medicine. 9. PMID 28404863 DOI: 10.1126/Scitranslmed.Aah5642  0.393
2017 Tierney MC, Curtis AF, Masellis M, Hsiung GR, Moineddin R, Zhang K, Au B, Millett G, Mackenzie IR, Rogaeva E. Sex Differences In The Prevalence Of Genetic Mutations In Ftd And Als: A Meta-Analysis Alzheimers & Dementia. 13: 1491. DOI: 10.1016/J.Jalz.2017.07.578  0.313
2017 Hughes SR, Boeve BF, Rosen HJ, Boxer AL, Calvert KJ, Dheel C, Dickerson BC, Fields JA, Gavrilova RH, Ghoshal N, Goldman J, Graff-Radford NR, Grossman M, Heuer H, Hsiung GR, ... ... Mackenzie IR, et al. Caregiver Burden In Familial Frontotemporal Dementia Subjects: Preliminary Data In The Lefftds Cohort Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.934  0.323
2017 Dheel CM, Boeve BF, Rosen HJ, Boxer AL, Coppola G, Dickerson BC, Faber K, Fields JA, Foroud TM, Gavrilova RH, Ghoshal N, Goldman J, Graff-Radford N, Grossman M, Heuer H, ... ... Mackenzie IR, et al. [P1-254]: CHARACTERISTICS AND PROGRESS ON THE INITIAL 209 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL Alzheimer's & Dementia. 13: P345-P345. DOI: 10.1016/J.Jalz.2017.06.270  0.318
2017 Campbell MC, Corapi F, Emptage L, Redekop R, Shah N, Kitor M, Hamel MT, Wong V, Hirsch-Reinshagen V, Robin Hsiung G, Mackenzie IR. [P1-116]: THE RELATIONSHIP BETWEEN AMYLOID IN THE RETINA AND A BRAIN-BASED POST-MORTEM DIAGNOSIS OF ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P284-P285. DOI: 10.1016/J.Jalz.2017.06.183  0.338
2016 Jan A, Jansonius B, Delaidelli A, Somasekharan SP, Bhanshali F, Vandal M, Negri GL, Moerman D, MacKenzie I, Calon F, Hayden MR, Taubert S, Sorensen PH. eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response. Acta Neuropathologica. PMID 27752775 DOI: 10.1007/S00401-016-1634-1  0.309
2016 Campbell MC, Kisilak ML, DeVries D, Cookson C, Hamel M, Chow T, Hunter JJ, Brooks M, Strazzeri J, Fischer W, DiVincenti L, Araujo JA, Mackenzie I, Ran C, Emptage L. O3-12-05: Amyloid as a Biomarker of Alzheimer's Disease in Post-Mortem Retinas in Human and Dog Models of Alzheimer's Disease Alzheimer's & Dementia. 12: P319-P320. DOI: 10.1016/J.Jalz.2016.06.577  0.325
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.348
2015 Xi Z, van Blitterswijk M, Zhang M, McGoldrick P, McLean JR, Yunusova Y, Knock E, Moreno D, Sato C, McKeever PM, Schneider R, Keith J, Petrescu N, Fraser P, Tartaglia MC, ... ... Mackenzie IR, et al. Jump from Pre-mutation to Pathologic Expansion in C9orf72. American Journal of Human Genetics. 96: 962-70. PMID 26004200 DOI: 10.1016/J.Ajhg.2015.04.016  0.339
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.361
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... ... Mackenzie IR, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.389
2014 Hallam BJ, Jacova C, Hsiung GY, Wittenberg D, Sengdy P, Bouchard-Kerr P, Slack P, Rademakers R, Baker M, Chow TW, Levine B, Feldman HH, Mackenzie IR. Early neuropsychological characteristics of progranulin mutation carriers. Journal of the International Neuropsychological Society : Jins. 20: 694-703. PMID 24993774 DOI: 10.1017/S1355617714000551  0.358
2014 Riedl L, Mackenzie IR, Förstl H, Kurz A, Diehl-Schmid J. Frontotemporal lobar degeneration: current perspectives. Neuropsychiatric Disease and Treatment. 10: 297-310. PMID 24600223 DOI: 10.2147/Ndt.S38706  0.392
2014 Proudfoot M, Gutowski NJ, Edbauer D, Hilton DA, Stephens M, Rankin J, Mackenzie IR. Early dipeptide repeat pathology in a frontotemporal dementia kindred with C9ORF72 mutation and intellectual disability. Acta Neuropathologica. 127: 451-8. PMID 24445903 DOI: 10.1007/s00401-014-1245-7  0.331
2014 Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer PO, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Human Molecular Genetics. 23: 1467-78. PMID 24163244 DOI: 10.1093/Hmg/Ddt534  0.302
2014 Arzberger T, Mori K, Mackenzie I, Neumann M, May S, Kremmer E, Kretzschmar H, Edbauer D. EPA-1718 - Neuropathological alterations in FTD cases with C9ORF72 mutation - new insights European Psychiatry. 29: 1. DOI: 10.1016/S0924-9338(14)78857-1  0.401
2013 Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/S00401-013-1181-Y  0.411
2013 Jacova C, Hsiung GY, Tawankanjanachot I, Dinelle K, McCormick S, Gonzalez M, Lee H, Sengdy P, Bouchard-Kerr P, Baker M, Rademakers R, Sossi V, Stoessl AJ, Feldman HH, Mackenzie IR. Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers. Neurology. 81: 1322-31. PMID 24005336 DOI: 10.1212/Wnl.0B013E3182A8237E  0.33
2013 Nicholson AM, Finch NA, Wojtas A, Baker MC, Perkerson RB, Castanedes-Casey M, Rousseau L, Benussi L, Binetti G, Ghidoni R, Hsiung GY, Mackenzie IR, Finger E, Boeve BF, Ertekin-Taner N, et al. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia. Journal of Neurochemistry. 126: 781-91. PMID 23742080 DOI: 10.1111/Jnc.12329  0.346
2013 Ravenscroft TA, Baker MC, Rutherford NJ, Neumann M, Mackenzie IR, Josephs KA, Boeve BF, Petersen R, Halliday GM, Kril J, van Swieten JC, Seeley WW, Dickson DW, Rademakers R. Mutations in protein N-arginine methyltransferases are not the cause of FTLD-FUS. Neurobiology of Aging. 34: 2235.e11-3. PMID 23635657 DOI: 10.1016/J.Neurobiolaging.2013.04.004  0.318
2013 Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, ... Mackenzie IR, et al. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 189-98. PMID 23062850 DOI: 10.1016/J.Jalz.2012.03.003  0.349
2013 Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, et al. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 176-88. PMID 23043900 DOI: 10.1016/J.Jalz.2012.03.002  0.344
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Mackenzie I, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.394
2012 Pokrishevsky E, Grad LI, Yousefi M, Wang J, Mackenzie IR, Cashman NR. Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis. Plos One. 7: e35050. PMID 22493728 DOI: 10.1371/Journal.Pone.0035050  0.35
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Mackenzie IR, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.344
2012 Hsiung GY, DeJesus-Hernandez M, Feldman HH, Sengdy P, Bouchard-Kerr P, Dwosh E, Butler R, Leung B, Fok A, Rutherford NJ, Baker M, Rademakers R, Mackenzie IR. Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p. Brain : a Journal of Neurology. 135: 709-22. PMID 22344582 DOI: 10.1093/Brain/Awr354  0.345
2012 Mackenzie I. Clinical, pathological and genetic aspects of C9ORF72 mutations Alzheimers & Dementia. 8: 729. DOI: 10.1016/J.Jalz.2012.05.1968  0.343
2012 Youn YC, Jacova C, Jang J, Sengdy P, Kee BS, Feldman H, Rademakers R, Mackenzie I, Hsiung G. Longitudinal gray and white matter changes in progranulin mutation carriers at risk for FTD: A VBM study Alzheimers & Dementia. 8: 689. DOI: 10.1016/J.Jalz.2012.05.1859  0.3
2011 Josephs KA, Hodges JR, Snowden JS, Mackenzie IR, Neumann M, Mann DM, Dickson DW. Neuropathological background of phenotypical variability in frontotemporal dementia. Acta Neuropathologica. 122: 137-53. PMID 21614463 DOI: 10.1007/S00401-011-0839-6  0.409
2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, ... ... Mackenzie IR, et al. Ataxin-2 repeat-length variation and neurodegeneration. Human Molecular Genetics. 20: 3207-12. PMID 21610160 DOI: 10.1093/Hmg/Ddr227  0.347
2011 Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, ... ... Mackenzie IR, et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology. 76: 467-74. PMID 21178100 DOI: 10.1212/Wnl.0B013E31820A0E3B  0.312
2011 Boxer AL, Mackenzie IR, Boeve BF, Baker M, Seeley WW, Crook R, Feldman H, Hsiung GY, Rutherford N, Laluz V, Whitwell J, Foti D, McDade E, Molano J, Karydas A, et al. Clinical, neuroimaging and neuropathological features of a new chromosome 9p-linked FTD-ALS family. Journal of Neurology, Neurosurgery, and Psychiatry. 82: 196-203. PMID 20562461 DOI: 10.1136/Jnnp.2009.204081  0.373
2011 Robertson J, Bilbao J, Zinman L, Hazrati LN, Tokuhiro S, Sato C, Moreno D, Strome R, Mackenzie IR, Rogaeva E. A novel double mutation in FUS gene causing sporadic ALS. Neurobiology of Aging. 32: 553.e27-30. PMID 20561714 DOI: 10.1016/J.Neurobiolaging.2010.05.015  0.369
2010 Hu F, Padukkavidana T, Vægter CB, Brady OA, Zheng Y, Mackenzie IR, Feldman HH, Nykjaer A, Strittmatter SM. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 68: 654-67. PMID 21092856 DOI: 10.1016/J.Neuron.2010.09.034  0.315
2010 Urwin H, Josephs KA, Rohrer JD, Mackenzie IR, Neumann M, Authier A, Seelaar H, Van Swieten JC, Brown JM, Johannsen P, Nielsen JE, Holm IE, Dickson DW, Rademakers R, et al. FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration. Acta Neuropathologica. 120: 33-41. PMID 20490813 DOI: 10.1007/S00401-010-0698-6  0.391
2010 Woodward M, Jacova C, Black SE, Kertesz A, Mackenzie IR, Feldman H. Differentiating the frontal variant of Alzheimer's disease. International Journal of Geriatric Psychiatry. 25: 732-8. PMID 19823987 DOI: 10.1002/Gps.2415  0.337
2010 Haass C, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than M, Mackenzie I, Capell A, Schmid B, Neumann M, Dormann D. O4-03-06: Familial Als-associated Fused in Sarcoma (fus) Mutations Disrupt Transportin-mediated Nuclear Import Alzheimer's & Dementia. 6: e17-e17. DOI: 10.1016/J.Jalz.2010.08.051  0.323
2009 Rohrer JD, Guerreiro R, Vandrovcova J, Uphill J, Reiman D, Beck J, Isaacs AM, Authier A, Ferrari R, Fox NC, Mackenzie IR, Warren JD, de Silva R, Holton J, Revesz T, et al. The heritability and genetics of frontotemporal lobar degeneration. Neurology. 73: 1451-6. PMID 19884572 DOI: 10.1212/Wnl.0B013E3181Bf997A  0.315
2009 Munoz DG, Neumann M, Kusaka H, Yokota O, Ishihara K, Terada S, Kuroda S, Mackenzie IR. FUS pathology in basophilic inclusion body disease. Acta Neuropathologica. 118: 617-27. PMID 19830439 DOI: 10.1007/S00401-009-0598-9  0.386
2009 Neumann M, Rademakers R, Roeber S, Baker M, Kretzschmar HA, Mackenzie IR. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain : a Journal of Neurology. 132: 2922-31. PMID 19674978 DOI: 10.1093/Brain/Awp214  0.314
2009 Arai T, Mackenzie IR, Hasegawa M, Nonoka T, Niizato K, Tsuchiya K, Iritani S, Onaya M, Akiyama H. Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies. Acta Neuropathologica. 117: 125-36. PMID 19139911 DOI: 10.1007/S00401-008-0480-1  0.303
2009 Mackenzie IR, Neumann M, Rademakers R, Munoz DG. Frontotemporal Dementia With FUS Pathology Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.07.128  0.362
2008 Rademakers R, Eriksen JL, Baker M, Robinson T, Ahmed Z, Lincoln SJ, Finch N, Rutherford NJ, Crook RJ, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Parisi JE, Caselli RJ, ... ... Mackenzie IR, et al. Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia. Human Molecular Genetics. 17: 3631-42. PMID 18723524 DOI: 10.1093/Hmg/Ddn257  0.32
2007 Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, ... ... Mackenzie IR, et al. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. The Lancet. Neurology. 6: 857-68. PMID 17826340 DOI: 10.1016/S1474-4422(07)70221-1  0.35
2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathologica. 114: 5-22. PMID 17579875 DOI: 10.1007/S00401-007-0237-2  0.331
2007 Van Raamsdonk JM, Murphy Z, Selva DM, Hamidizadeh R, Pearson J, Petersén A, Björkqvist M, Muir C, Mackenzie IR, Hammond GL, Vogl AW, Hayden MR, Leavitt BR. Testicular degeneration in Huntington disease. Neurobiology of Disease. 26: 512-20. PMID 17433700 DOI: 10.1016/J.Nbd.2007.01.006  0.324
2007 Neumann M, Mackenzie IR, Cairns NJ, Boyer PJ, Markesbery WR, Smith CD, Taylor JP, Kretzschmar HA, Kimonis VE, Forman MS. TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations. Journal of Neuropathology and Experimental Neurology. 66: 152-7. PMID 17279000 DOI: 10.1096/Fasebj.21.5.A25  0.425
2006 Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (New York, N.Y.). 314: 130-3. PMID 17023659 DOI: 10.1126/Science.1134108  0.312
2006 Snowden JS, Pickering-Brown SM, Mackenzie IR, Richardson AM, Varma A, Neary D, Mann DM. Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia. Brain : a Journal of Neurology. 129: 3091-102. PMID 17003069 DOI: 10.1093/Brain/Awl267  0.439
2006 Gass J, Cannon A, Mackenzie IR, Boeve B, Baker M, Adamson J, Crook R, Melquist S, Kuntz K, Petersen R, Josephs K, Pickering-Brown SM, Graff-Radford N, Uitti R, Dickson D, et al. Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. Human Molecular Genetics. 15: 2988-3001. PMID 16950801 DOI: 10.1093/Hmg/Ddl241  0.381
2006 Mackenzie IR, Butland SL, Devon RS, Dwosh E, Feldman H, Lindholm C, Neal SJ, Ouellette BF, Leavitt BR. Familial frontotemporal dementia with neuronal intranuclear inclusions is not a polyglutamine expansion disease. Bmc Neurology. 6: 32. PMID 16945149 DOI: 10.1186/1471-2377-6-32  0.414
2006 Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, Cannon A, Dwosh E, Neary D, Melquist S, Richardson A, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 442: 916-9. PMID 16862116 DOI: 10.1038/Nature05016  0.426
2006 Forman MS, Mackenzie IR, Cairns NJ, Swanson E, Boyer PJ, Drachman DA, Jhaveri BS, Karlawish JH, Pestronk A, Smith TW, Tu PH, Watts GD, Markesbery WR, Smith CD, Kimonis VE. Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. Journal of Neuropathology and Experimental Neurology. 65: 571-81. PMID 16783167 DOI: 10.1097/00005072-200606000-00005  0.411
2006 Stewart HG, Mackenzie IR, Eisen A, Brännström T, Marklund SL, Andersen PM. Clinicopathological phenotype of ALS with a novel G72C SOD1 gene mutation mimicking a myopathy. Muscle & Nerve. 33: 701-6. PMID 16435343 DOI: 10.1002/Mus.20495  0.315
2006 Mackenzie IR, Baker M, West G, Woulfe J, Qadi N, Gass J, Cannon A, Adamson J, Feldman H, Lindholm C, Melquist S, Pettman R, Sadovnick AD, Dwosh E, Whiteheart SW, et al. A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain : a Journal of Neurology. 129: 853-67. PMID 16401619 DOI: 10.1093/Brain/Awh724  0.37
2006 Campbell MC, Emptage L, Redekop R, Corapi F, Mason E, Hirsch-Reinshagen V, Kitor M, Shah N, Hamel MT, Robin Hsiung G, Mackenzie IR. P2-258: AMYLOID DEPOSITS IMAGED IN POSTMORTEM RETINAS USING POLARIMETRY PREDICT THE SEVERITY OF A POSTMORTEM BRAIN BASED DIAGNOSIS OF ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P774-P775. DOI: 10.1016/J.Jalz.2018.06.947  0.332
2006 Chu SA, Flagan TM, Jiskoot LC, Seeley WW, Papma JM, Deng J, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Brushaber D, Grossman M, Coppola G, Dickerson BC, Bordelon YM, ... ... Mackenzie IR, et al. P1-433: GRAY MATTER DEFICITS IN SYMPTOMATIC AND PRESYMPTOMATIC MAPT MUTATION CARRIERS Alzheimer's & Dementia. 14: P475-P476. DOI: 10.1016/J.Jalz.2018.06.442  0.325
2006 Forsberg LK, Boeve BF, Rosen HJ, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields JA, Fong J, Foroud TM, Gavrilova RH, ... ... Mackenzie IR, et al. O2-14-01: CHARACTERISTICS AND PROGRESS OF 320 SUBJECTS IN THE LONGITUDINAL EVALUATION OF FAMILIAL FRONTOTEMPORAL DEMENTIA SUBJECTS (LEFFTDS) PROTOCOL Alzheimer's & Dementia. 14: P656-P656. DOI: 10.1016/J.Jalz.2018.06.2718  0.306
2006 Woodward M, Mackenzie IR, Feldman H. P3-176: High prevalence of multiple brain pathologies in dementia Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1444  0.326
2005 Miklossy J, Mackenzie IR, Dorovini-Zis K, Calne DB, Wszolek ZK, Klegeris A, McGeer PL. Severe vascular disturbance in a case of familial brain calcinosis. Acta Neuropathologica. 109: 643-53. PMID 15937691 DOI: 10.1007/S00401-005-1007-7  0.301
2004 Mackenzie IR, Feldman H. Extrapyramidal features in patients with motor neuron disease and dementia; a clinicopathological correlative study. Acta Neuropathologica. 107: 336-40. PMID 14745570 DOI: 10.1007/S00401-003-0814-Y  0.367
2004 Grand J, Hsiung R, Donald A, Mackenzie IR, Feldman H. P1-010 Longitudinal rates of decline of the spectrum of degenerative dementias: findings from the Canadian collaborative cohort study of related dementias (ACCORD) Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80324-5  0.342
2003 Diehl J, Mackenzie IR, Förstl H, Kurz A. [Frontotemporal dementia. Results from "Frontotemporal Demential and Pick's Disease Conference"]. Der Nervenarzt. 74: 785-7. PMID 14504778 DOI: 10.1007/S00115-003-1509-2  0.34
2000 Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, ... ... Mackenzie IR, et al. Inflammation and Alzheimer's disease. Neurobiology of Aging. 21: 383-421. PMID 10858586 DOI: 10.1016/S0197-4580(00)00124-X  0.321
1996 Kertesz A, Hudson L, MacKenzie I, Munoz D. Reply from the Authors Primary progressive aphasia and frontal lobe involvement Neurology. 46: 290-291. DOI: 10.1212/Wnl.46.1.290  0.31
1990 Masters CL, Bush A, Evin G, Fuller S, Li Q, Mackenzie I, Milward E, Moir R, Small D, Beyreuther K. The βA4 amyloid protein and its precursors as biological markers for Alzheimer's disease Neurobiology of Aging. 11: 330-331. DOI: 10.1016/0197-4580(90)90874-Y  0.326
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