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Eliezer Masliah, MD, National Autonomous University of Mexico 1983 - Publications

Affiliations: 
Pathology and Medicine University of California, San Diego, La Jolla, CA 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=7
Website:
http://molpath.ucsd.edu/faculty/Masliah.shtml
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Year Citation  Score
2020 Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Masliah E, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2  0.41
2020 Iba M, Kim C, Sallin M, Kwon S, Verma A, Overk C, Rissman RA, Sen R, Sen JM, Masliah E. Neuroinflammation is associated with infiltration of T cells in Lewy body disease and α-synuclein transgenic models. Journal of Neuroinflammation. 17: 214. PMID 32680537 DOI: 10.1186/S12974-020-01888-0  0.38
2020 Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Adiponectin Paradox as a Therapeutic Target in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32623396 DOI: 10.3233/Jad-200416  0.38
2020 Ghatak S, Dolatabadi N, Gao R, Wu Y, Scott H, Trudler D, Sultan A, Ambasudhan R, Nakamura T, Masliah E, Talantova M, Voytek B, Lipton SA. NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models. Molecular Psychiatry. PMID 32467645 DOI: 10.1038/S41380-020-0776-7  0.362
2020 Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Waragai M, Masliah E, Takenouchi T. Understanding Creutzfeldt-Jackob disease from a viewpoint of amyloidogenic evolvability. Prion. 14: 1-8. PMID 32375593 DOI: 10.1080/19336896.2020.1761514  0.354
2020 Kwon S, Iba M, Kim C, Masliah E. Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32347461 DOI: 10.1007/S13311-020-00853-2  0.408
2020 Waragai M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Adiponectin Paradox in Alzheimer's Disease; Relevance to Amyloidogenic Evolvability? Frontiers in Endocrinology. 11: 108. PMID 32194507 DOI: 10.3389/Fendo.2020.00108  0.384
2020 Marschallinger J, Altendorfer B, Rockenstein E, Holztrattner M, Garnweidner-Raith J, Pillichshammer N, Leister I, Hutter-Paier B, Strempfl K, Unger MS, Chishty M, Felder T, Johnson M, Attems J, Masliah E, et al. The Leukotriene Receptor Antagonist Montelukast Reduces Alpha-Synuclein Load and Restores Memory in an Animal Model of Dementia with Lewy Bodies. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32072462 DOI: 10.1007/S13311-020-00836-3  0.373
2020 Orme T, Hernandez D, Ross OA, Kun-Rodrigues C, Darwent L, Shepherd CE, Parkkinen L, Ansorge O, Clark L, Honig LS, Marder K, Lemstra A, Rogaeva E, St George-Hyslop P, Londos E, ... ... Masliah E, et al. Analysis of neurodegenerative disease-causing genes in dementia with Lewy bodies. Acta Neuropathologica Communications. 8: 5. PMID 31996268 DOI: 10.1186/S40478-020-0879-Z  0.35
2020 Chen C, Guderyon MJ, Li Y, Ge G, Bhattacharjee A, Ballard C, He Z, Masliah E, Clark RA, O'Connor JC, Li S. Non-toxic HSC Transplantation-Based Macrophage/Microglia-Mediated GDNF Delivery for Parkinson's Disease. Molecular Therapy. Methods & Clinical Development. 17: 83-98. PMID 31890743 DOI: 10.1016/J.Omtm.2019.11.013  0.324
2019 Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, ... ... Masliah E, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain : a Journal of Neurology. PMID 31755958 DOI: 10.1093/Brain/Awz350  0.318
2019 Kwon S, Iba M, Masliah E, Kim C. Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies. Experimental Neurobiology. 28: 547-553. PMID 31698547 DOI: 10.5607/En.2019.28.5.547  0.341
2019 Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E. Possible Role of Amyloid Cross-Seeding in Evolvability and Neurodegenerative Disease. Journal of Parkinson's Disease. PMID 31524179 DOI: 10.3233/Jpd-191675  0.314
2019 Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, ... ... Masliah E, et al. Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo. Neurobiology of Disease. 104582. PMID 31445162 DOI: 10.1016/J.Nbd.2019.104582  0.311
2019 Mandler M, Rockenstein E, Overk C, Mante M, Florio J, Adame A, Kim C, Santic R, Schneeberger A, Mattner F, Schmidhuber S, Galabova G, Spencer B, Masliah E, Rissman RA. Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31378574 DOI: 10.1016/J.Jalz.2019.02.002  0.352
2019 He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, ... ... Masliah E, et al. NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. Cellular & Molecular Immunology. PMID 31320730 DOI: 10.1038/S41423-019-0260-Y  0.317
2019 Gerez JA, Prymaczok NC, Rockenstein E, Herrmann US, Schwarz P, Adame A, Enchev RI, Courtheoux T, Boersema PJ, Riek R, Peter M, Aguzzi A, Masliah E, Picotti P. A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology. Science Translational Medicine. 11. PMID 31167929 DOI: 10.1126/Scitranslmed.Aau6722  0.359
2019 van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, ... ... Masliah E, et al. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathologica. PMID 31131421 DOI: 10.1007/S00401-019-02026-8  0.342
2019 Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathologica Communications. 7: 77. PMID 31101070 DOI: 10.1186/S40478-019-0723-5  0.383
2019 Hategan A, Masliah E, Nath A. HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein. Journal of Neurovirology. PMID 31016584 DOI: 10.1007/S13365-019-00736-Z  0.332
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... ... Masliah E, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/J.Nbd.2019.04.004  0.307
2019 Okamoto SI, Prikhodko O, Pina-Crespo J, Adame A, McKercher SR, Brill LM, Nakanishi N, Oh CK, Nakamura T, Masliah E, Lipton SA. NitroSynapsin for the treatment of neurological manifestations of tuberous sclerosis complex in a rodent model. Neurobiology of Disease. PMID 30928642 DOI: 10.1016/J.Nbd.2019.03.029  0.329
2019 Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiology of Disease. PMID 30849508 DOI: 10.1016/J.Nbd.2019.03.001  0.377
2019 Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, et al. Assessment of APOE in atypical parkinsonism syndromes. Neurobiology of Disease. PMID 30798004 DOI: 10.1016/J.Nbd.2019.02.016  0.343
2019 Mackiewicz MM, Overk C, Achim CL, Masliah E. Pathogenesis of age-related HIV neurodegeneration. Journal of Neurovirology. PMID 30790184 DOI: 10.1007/S13365-019-00728-Z  0.33
2019 Takamatsu Y, Ho G, Waragai M, Wada R, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Transgenerational Interaction of Alzheimer's Disease with Schizophrenia through Amyloid Evolvability. Journal of Alzheimer's Disease : Jad. PMID 30741673 DOI: 10.3233/Jad-180986  0.388
2019 Snow AD, Castillo GM, Nguyen BP, Choi PY, Cummings JA, Cam J, Hu Q, Lake T, Pan W, Kastin AJ, Kirschner DA, Wood SG, Rockenstein E, Masliah E, Lorimer S, et al. The Amazon rain forest plant Uncaria tomentosa (cat's claw) and its specific proanthocyanidin constituents are potent inhibitors and reducers of both brain plaques and tangles. Scientific Reports. 9: 561. PMID 30728442 DOI: 10.1038/S41598-019-38645-0  0.399
2019 Mao W, Shanbhag NM, Evans MD, Li AN, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. P1-217: Early Neuronal Accumulation Of Dna Double Strand Breaks In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.772  0.336
2018 Takamatsu Y, Fujita M, Ho GJ, Wada R, Sugama S, Takenouchi T, Waragai M, Masliah E, Hashimoto M. Motor and Nonmotor Symptoms of Parkinson's Disease: Antagonistic Pleiotropy Phenomena Derived from -Synuclein Evolvability? Parkinson's Disease. 2018: 5789424. PMID 30595837 DOI: 10.1155/2018/5789424  0.329
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, ... ... Masliah E, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/J.Neurobiolaging.2018.10.019  0.301
2018 Price DL, Koike MA, Khan A, Wrasidlo W, Rockenstein E, Masliah E, Bonhaus D. The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson's disease. Scientific Reports. 8: 16165. PMID 30385782 DOI: 10.1038/S41598-018-34490-9  0.398
2018 Hashimoto M, Ho G, Takamatsu Y, Wada R, Sugama S, Takenouchi T, Masliah E, Waragai M. Possible Role of the Polyglutamine Elongation in Evolution of Amyloid-Related Evolvability. Journal of Huntington's Disease. PMID 30372687 DOI: 10.3233/Jhd-180309  0.392
2018 Hellmuth J, Milanini B, Masliah E, Tartaglia MC, Dunlop MB, Moore DJ, Javandel S, DeVaughn S, Valcour V. A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder. Neurocase. 1-7. PMID 30304986 DOI: 10.1080/13554794.2018.1530362  0.313
2018 Fields JA, Spencer B, Swinton M, Qvale EM, Marquine MJ, Alexeeva A, Gough S, Soontornniyomkij B, Valera E, Masliah E, Achim CL, Desplats P. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. Journal of Neurochemistry. PMID 30152135 DOI: 10.1111/Jnc.14582  0.365
2018 Chen XQ, Fang F, Florio JB, Rockenstein E, Masliah E, Mobley WC, Rissman RA, Wu C. TRiC enhances retrograde axonal transport by modulating tau phosphorylation. Traffic (Copenhagen, Denmark). PMID 30120810 DOI: 10.1111/Tra.12610  0.323
2018 Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Molecular Neurodegeneration. 13: 43. PMID 30092810 DOI: 10.1186/S13024-018-0276-2  0.326
2018 Hashimoto M, Ho G, Takamatsu Y, Shimizu Y, Sugama S, Takenouchi T, Waragai M, Masliah E. Evolvability and Neurodegenerative Disease: Antagonistic Pleiotropy Phenomena Derived from Amyloid Aggregates. Journal of Parkinson's Disease. PMID 30010144 DOI: 10.3233/Jpd-181365  0.402
2018 Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, et al. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proceedings of the National Academy of Sciences of the United States of America. PMID 29991596 DOI: 10.1073/Pnas.1713129115  0.313
2018 Spencer B, Brüschweiler S, Sealey-Cardona M, Rockenstein E, Adame A, Florio J, Mante M, Trinh I, Rissman RA, Konrat R, Masliah E. Selective targeting of 3 repeat Tau with brain penetrating single chain antibodies for the treatment of neurodegenerative disorders. Acta Neuropathologica. 136: 69-87. PMID 29934874 DOI: 10.1007/S00401-018-1869-0  0.39
2018 González RG, Fell R, He J, Campbell J, Burdo TH, Autissier P, Annamalai L, Taheri F, Parker T, Lifson JD, Halpern EF, Vangel M, Masliah E, Westmoreland SV, Williams KC, et al. Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS. Plos One. 13: e0196949. PMID 29750804 DOI: 10.1371/Journal.Pone.0196949  0.304
2018 Silverberg N, Elliott C, Ryan L, Masliah E, Hodes R. NIA commentary on the NIA-AA Research Framework: Towards a biological definition of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 14: 576-578. PMID 29653608 DOI: 10.1016/J.Jalz.2018.03.004  0.325
2018 Unger MS, Marschallinger J, Kaindl J, Klein B, Johnson M, Khundakar AA, Roßner S, Heneka MT, Couillard-Despres S, Rockenstein E, Masliah E, Attems J, Aigner L. Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology? Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29630865 DOI: 10.1016/J.Jalz.2018.02.017  0.316
2018 Chen C, Li X, Ge G, Liu J, Biju KC, Laing SD, Qian Y, Ballard C, He Z, Masliah E, Clark RA, O'Connor JC, Li S. GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice. Scientific Reports. 8: 5460. PMID 29615705 DOI: 10.1038/S41598-018-23795-4  0.349
2018 Tulloch J, Leong L, Chen S, Keene CD, Millard SP, Shutes-David A, Lopez OL, Kofler J, Kaye JA, Woltjer R, Nelson PT, Neltner JH, Jicha GA, Galasko D, Masliah E, et al. APOE DNA methylation is altered in Lewy body dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29544979 DOI: 10.1016/J.Jalz.2018.02.005  0.339
2018 Min SW, Sohn PD, Li Y, Devidze N, Johnson JR, Krogan NJ, Masliah E, Mok SA, Gestwicki JE, Gan L. SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29540553 DOI: 10.1523/Jneurosci.2369-17.2018  0.409
2018 Hashimoto M, Ho G, Sugama S, Takamatsu Y, Shimizu Y, Takenouchi T, Waragai M, Masliah E. Evolvability of Amyloidogenic Proteins in Human Brain. Journal of Alzheimer's Disease : Jad. 62: 73-83. PMID 29439348 DOI: 10.3233/Jad-170894  0.321
2018 Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. Journal of Alzheimer's Disease : Jad. 61: 1201-1219. PMID 29332037 DOI: 10.3233/Jad-170388  0.405
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, ... ... Masliah E, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  0.304
2017 Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, ... ... Masliah E, et al. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Science Translational Medicine. 9. PMID 29212711 DOI: 10.1126/Scitranslmed.Aal2332  0.331
2017 Minakaki G, Menges S, Kittel A, Emmanouilidou E, Schaeffner I, Barkovits K, Bergmann A, Rockenstein E, Adame A, Marxreiter F, Mollenhauer B, Galasko D, Buzás EI, Schlötzer-Schrehardt U, Marcus K, ... ... Masliah E, et al. Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. Autophagy. 1-61. PMID 29198173 DOI: 10.1080/15548627.2017.1395992  0.369
2017 Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/J.Celrep.2017.11.009  0.449
2017 Zhu B, Jiang L, Huang T, Zhao Y, Liu T, Zhong Y, Li X, Campos A, Pomeroy K, Masliah E, Zhang D, Xu H. ER-associated degradation regulates Alzheimer's amyloid pathology and memory function by modulating γ-secretase activity. Nature Communications. 8: 1472. PMID 29133892 DOI: 10.1038/S41467-017-01799-4  0.422
2017 Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Masliah E, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/S41467-017-01563-8  0.362
2017 Huang TY, Zhao Y, Jiang LL, Li X, Liu Y, Sun Y, Piña-Crespo JC, Zhu B, Masliah E, Willnow TE, Pasquale EB, Xu H. SORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration. The Journal of Experimental Medicine. PMID 29114064 DOI: 10.1084/Jem.20171413  0.432
2017 Ihse E, Yamakado H, van Wijk XM, Lawrence R, Esko JD, Masliah E. Cellular internalization of alpha-synuclein aggregates by cell surface heparan sulfate depends on aggregate conformation and cell type. Scientific Reports. 7: 9008. PMID 28827536 DOI: 10.1038/S41598-017-08720-5  0.376
2017 Waragai M, Ho G, Takamatsu Y, Sekiyama K, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Importance of adiponectin activity in the pathogenesis of Alzheimer's disease. Annals of Clinical and Translational Neurology. 4: 591-600. PMID 28812049 DOI: 10.1002/Acn3.436  0.386
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Masliah E, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.316
2017 Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Scientific Reports. 7: 3868. PMID 28634349 DOI: 10.1038/S41598-017-04232-4  0.421
2017 Reilly P, Winston CN, Baron K, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiology of Disease. PMID 28610892 DOI: 10.1016/J.Jalz.2016.07.031  0.413
2017 McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, ... ... Masliah E, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. PMID 28592453 DOI: 10.1212/Wnl.0000000000004058  0.316
2017 El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiology of Disease. PMID 28476636 DOI: 10.1016/J.Nbd.2017.05.002  0.301
2017 Kouroupi G, Taoufik E, Vlachos IS, Tsioras K, Antoniou N, Papastefanaki F, Chroni-Tzartou D, Wrasidlo W, Bohl D, Stellas D, Politis PK, Vekrellis K, Papadimitriou D, Stefanis L, Bregestovski P, ... ... Masliah E, et al. Defective synaptic connectivity and axonal neuropathology in a human iPSC-based model of familial Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416701 DOI: 10.1073/Pnas.1617259114  0.371
2017 Ferrero K, Silver M, Cocchetto A, Masliah E, Langford D. CNS findings in chronic fatigue syndrome and a neuropathological case report. Journal of Investigative Medicine : the Official Publication of the American Federation For Clinical Research. PMID 28386034 DOI: 10.1136/Jim-2016-000390  0.309
2017 Hategan A, Bianchet MA, Steiner J, Karnaukhova E, Masliah E, Fields A, Lee MH, Dickens AM, Haughey N, Dimitriadis EK, Nath A. HIV Tat protein and amyloid-β peptide form multifibrillar structures that cause neurotoxicity. Nature Structural & Molecular Biology. PMID 28218748 DOI: 10.1038/Nsmb.3379  0.34
2017 Fields JA, Metcalf J, Overk C, Adame A, Spencer B, Wrasidlo W, Florio J, Rockenstein E, He JJ, Masliah E. The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. Journal of Neurovirology. PMID 28105557 DOI: 10.1007/S13365-016-0502-Z  0.362
2017 Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathologica Communications. 5: 7. PMID 28086964 DOI: 10.1186/S40478-016-0410-8  0.308
2017 Valera E, Spencer B, Fields JA, Trinh I, Adame A, Mante M, Rockenstein E, Desplats P, Masliah E. Combination of alpha-synuclein immunotherapy with anti-inflammatory treatment in a transgenic mouse model of multiple system atrophy. Acta Neuropathologica Communications. 5: 2. PMID 28057080 DOI: 10.1186/S40478-016-0409-1  0.332
2017 Unger MS, Marschallinger J, Klein B, Johnson M, Khundakar AA, Heneka M, Couillard-Despres S, Masliah E, Attems J, Aigner L. Immune Cell Interactions In Amyloid-Beta Plaque Pathology Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1341  0.307
2016 Adamowicz DH, Roy S, Salmon DP, Galasko DR, Hansen LA, Masliah E, Gage FH. Hippocampal α-Synuclein in Dementia with Lewy Bodies Contributes to Memory Impairment and is Consistent with Spread of Pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28039370 DOI: 10.1523/Jneurosci.3047-16.2016  0.641
2016 Lipton SA, Rezaie T, Nutter A, Lopez KM, Parker J, Kosaka K, Satoh T, McKercher SR, Masliah E, Nakanishi N. Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death & Disease. 7: e2499. PMID 27906174 DOI: 10.1038/Cddis.2016.389  0.399
2016 Cronin P, McCarthy MJ, Lim AS, Salmon DP, Galasko D, Masliah E, De Jager PL, Bennett DA, Desplats P. Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27883893 DOI: 10.1016/J.Jalz.2016.10.003  0.34
2016 Sunico CR, Sultan A, Nakamura T, Dolatabadi N, Parker J, Shan B, Han X, Yates JR, Masliah E, Ambasudhan R, Nakanishi N, Lipton SA. Role of sulfiredoxin as a peroxiredoxin-2 denitrosylase in human iPSC-derived dopaminergic neurons. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821734 DOI: 10.1073/Pnas.1608784113  0.341
2016 Chen SG, Stribinskis V, Rane MJ, Demuth DR, Gozal E, Roberts AM, Jagadapillai R, Liu R, Choe K, Shivakumar B, Son F, Jin S, Kerber R, Adame A, Masliah E, et al. Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans. Scientific Reports. 6: 34477. PMID 27708338 DOI: 10.1038/Srep34477  0.354
2016 Wrasidlo W, Tsigelny IF, Price DL, Dutta G, Rockenstein E, Schwarz TC, Ledolter K, Bonhaus D, Paulino A, Eleuteri S, Skjevik ÅA, Kouznetsova VL, Spencer B, Desplats P, Gonzalez-Ruelas T, ... ... Masliah E, et al. A de novo compound targeting α-synuclein improves deficits in models of Parkinson's disease. Brain : a Journal of Neurology. PMID 27679481 DOI: 10.1093/Brain/Aww238  0.343
2016 Spencer B, Williams S, Rockenstein E, Valera E, Xin W, Mante M, Florio J, Adame A, Masliah E, Sierks MR. α-synuclein conformational antibodies fused to penetratin are effective in models of Lewy body disease. Annals of Clinical and Translational Neurology. 3: 588-606. PMID 27606342 DOI: 10.1002/Acn3.321  0.302
2016 Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. Jama Neurology. PMID 27598869 DOI: 10.1001/Jamaneurol.2016.3185  0.356
2016 Xu J, de Winter F, Farrokhi C, Rockenstein E, Mante M, Adame A, Cook J, Jin X, Masliah E, Lee KF. Neuregulin 1 improves cognitive deficits and neuropathology in an Alzheimer's disease model. Scientific Reports. 6: 31692. PMID 27558862 DOI: 10.1038/Srep31692  0.422
2016 Kratter IH, Zahed H, Lau A, Tsvetkov AS, Daub AC, Weiberth KF, Gu X, Saudou F, Humbert S, Yang XW, Osmand A, Steffan JS, Masliah E, Finkbeiner S. Serine 421 regulates mutant huntingtin toxicity and clearance in mice. The Journal of Clinical Investigation. PMID 27525439 DOI: 10.1172/Jci80339  0.371
2016 Kim C, Lv G, Lee JS, Jung BC, Masuda-Suzukake M, Hong CS, Valera E, Lee HJ, Paik SR, Hasegawa M, Masliah E, Eliezer D, Lee SJ. Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril. Scientific Reports. 6: 30891. PMID 27488222 DOI: 10.1038/Srep30891  0.323
2016 Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7971-84. PMID 27466341 DOI: 10.1523/Jneurosci.0775-16.2016  0.428
2016 Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, Masliah E, Rissman RA. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimer's & Dementia (Amsterdam, Netherlands). 3: 63-72. PMID 27408937 DOI: 10.1016/J.Jalz.2016.06.953  0.362
2016 Price DL, Rockenstein E, Mante M, Adame A, Overk C, Spencer B, Duong-Polk KX, Bonhaus D, Lindsey J, Masliah E. Longitudinal live imaging of retinal α-synuclein::GFP deposits in a transgenic mouse model of Parkinson's Disease/Dementia with Lewy Bodies. Scientific Reports. 6: 29523. PMID 27389831 DOI: 10.1038/Srep29523  0.32
2016 Kim C, Lee HJ, Masliah E, Lee SJ. Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2. Experimental Neurobiology. 25: 113-9. PMID 27358579 DOI: 10.5607/En.2016.25.3.113  0.351
2016 Gillman AL, Lee J, Ramachandran S, Capone R, Gonzalez T, Wrasidlo W, Masliah E, Lal R. Small molecule NPT-440-1 inhibits ionic flux through Aβ1-42 pores: implications for Alzheimer's disease therapeutics. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 27335341 DOI: 10.1016/J.Nano.2016.06.001  0.393
2016 Uhlirova H, Kılıç K, Tian P, Thunemann M, Desjardins M, Saisan PA, Sakadžić S, Ness TV, Mateo C, Cheng Q, Weldy KL, Razoux F, Vanderberghe M, Cremonesi JA, Ferri CG, ... ... Masliah E, et al. Cell type specificity of neurovascular coupling in cerebral cortex. Elife. 5. PMID 27244241 DOI: 10.7554/Elife.14315  0.305
2016 Fields JA, Overk C, Adame A, Florio J, Mante M, Pineda A, Desplats P, Rockenstein E, Achim C, Masliah E. Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity. Journal of Neuroinflammation. 13: 120. PMID 27220536 DOI: 10.1186/S12974-016-0585-8  0.346
2016 Alvarez XA, Alvarez I, Iglesias O, Crespo I, Figueroa J, Aleixandre M, Linares C, Granizo E, Garcia-Fantini M, Marey J, Masliah E, Winter S, Muresanu D, Moessler H. Synergistic Increase of Serum BDNF in Alzheimer Patients Treated with Cerebrolysin and Donepezil: Association with Cognitive Improvement in ApoE4 Cases. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 27207906 DOI: 10.1093/Ijnp/Pyw024  0.329
2016 Rockenstein E, Clarke J, Viel C, Panarello N, Treleaven CM, Kim C, Spencer B, Adame A, Park H, Dodge JC, Cheng SH, Shihabuddin LS, Masliah E, Sardi SP. Glucocerebrosidase Modulates Cognitive and Motor Activities in Murine Models of Parkinson's Disease. Human Molecular Genetics. PMID 27126635 DOI: 10.1093/Hmg/Ddw124  0.343
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, ... ... Masliah E, et al. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 31. PMID 27112350 DOI: 10.1186/S13024-016-0095-2  0.338
2016 Soontornniyomkij V, Umlauf A, Soontornniyomkij B, Batki IB, Moore DJ, Masliah E, Achim CL. Lifetime methamphetamine dependence is associated with cerebral microgliosis in HIV-1-infected adults. Journal of Neurovirology. PMID 27098516 DOI: 10.1007/S13365-016-0441-8  0.313
2016 Waragai M, Adame A, Trinh I, Sekiyama K, Takamatsu Y, Une K, Masliah E, Hashimoto M. Possible Involvement of Adiponectin, the Anti-Diabetes Molecule, in the Pathogenesis of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 27079710 DOI: 10.3233/Jad-151116  0.392
2016 Belichenko PV, Madani R, Rey-Bellet L, Pihlgren M, Becker A, Plassard A, Vuillermot S, Giriens V, Nosheny RL, Kleschevnikov AM, Valletta JS, Bengtsson SK, Linke GR, Maloney MT, Hickman DT, ... ... Masliah E, et al. An Anti-β-Amyloid Vaccine for Treating Cognitive Deficits in a Mouse Model of Down Syndrome. Plos One. 11: e0152471. PMID 27023444 DOI: 10.1371/Journal.Pone.0152471  0.385
2016 Avdoshina V, Fields JA, Castellano P, Dedoni S, Palchik G, Trejo M, Adame A, Rockenstein E, Eugenin E, Masliah E, Mocchetti I. The HIV Protein gp120 Alters Mitochondrial Dynamics in Neurons. Neurotoxicity Research. PMID 26936603 DOI: 10.1007/S12640-016-9608-6  0.314
2016 Maeda S, Djukic B, Taneja P, Yu GQ, Lo I, Davis A, Craft R, Guo W, Wang X, Kim D, Ponnusamy R, Gill TM, Masliah E, Mucke L. Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice. Embo Reports. PMID 26931567 DOI: 10.15252/Embr.201541438  0.444
2016 Simonovitch S, Schmukler E, Bespalko A, Iram T, Frenkel D, Holtzman DM, Masliah E, Michaelson DM, Pinkas-Kramarski R. Impaired Autophagy in APOE4 Astrocytes. Journal of Alzheimer's Disease : Jad. PMID 26923027 DOI: 10.3233/Jad-151101  0.418
2016 Bachis A, Forcelli P, Masliah E, Campbell L, Mocchetti I. Expression of gp120 in mice evokes anxiety behavior: co-occurrence with increased dendritic spines and brain-derived neurotrophic factor in the amygdala. Brain, Behavior, and Immunity. PMID 26845379 DOI: 10.1016/J.Bbi.2016.01.020  0.326
2016 Fares MB, Maco B, Oueslati A, Rockenstein E, Ninkina N, Buchman VL, Masliah E, Lashuel HA. Induction of de novo α-synuclein fibrillization in a neuronal model for Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 26839406 DOI: 10.1073/Pnas.1512876113  0.381
2016 Spencer B, Kim C, Gonzalez T, Bisquertt A, Patrick C, Rockenstein E, Adame A, Lee SJ, Desplats P, Masliah E. α-Synuclein interferes with the ESCRT-III complex contributing to the pathogenesis of Lewy Body disease. Human Molecular Genetics. PMID 26740557 DOI: 10.1093/Hmg/Ddv633  0.321
2015 Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Moessler H, Masliah E. Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease. Journal of Experimental Neuroscience. 9: 131-40. PMID 27429559 DOI: 10.4137/Jen.S25521  0.334
2015 Kim C, Ojo-Amaize E, Spencer B, Rockenstein E, Mante M, Desplats P, Wrasidlo W, Adame A, Nchekwube E, Oyemade O, Okogun J, Chan M, Cottam H, Masliah E. Hypoestoxide reduces neuroinflammation and α-synuclein accumulation in a mouse model of Parkinson's disease. Journal of Neuroinflammation. 12: 236. PMID 26683203 DOI: 10.1186/S12974-015-0455-9  0.392
2015 Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MM, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, ... ... Masliah E, et al. PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically. Nature Medicine. PMID 26642438 DOI: 10.1038/Nm.4003  0.378
2015 Levine AJ, Soontornniyomkij V, Achim CL, Masliah E, Gelman BB, Sinsheimer JS, Singer EJ, Moore DJ. Multilevel analysis of neuropathogenesis of neurocognitive impairment in HIV. Journal of Neurovirology. PMID 26637429 DOI: 10.1007/S13365-015-0410-7  0.336
2015 Spencer B, Potkar R, Metcalf J, Trinh I, Adame A, Rockenstein E, Masliah E. Systemic CNS-targeted Delivery of NPY Reduces Neurodegeneration and Increases Neural Precursor Cell Proliferation in a Mouse Model of Alzheimer's Disease. The Journal of Biological Chemistry. PMID 26620558 DOI: 10.1074/Jbc.M115.678185  0.423
2015 Suberbielle E, Djukic B, Evans M, Kim DH, Taneja P, Wang X, Finucane M, Knox J, Ho K, Devidze N, Masliah E, Mucke L. DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice. Nature Communications. 6: 8897. PMID 26615780 DOI: 10.1038/Ncomms9897  0.409
2015 Rockenstein E, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. Neuroprotective effects of Cerebrolysin in triple repeat Tau transgenic model of Pick's disease and fronto-temporal tauopathies. Bmc Neuroscience. 16: 85. PMID 26611895 DOI: 10.1186/S12868-015-0218-7  0.385
2015 Fields JA, Serger E, Campos S, Divakaruni AS, Kim C, Smith K, Trejo M, Adame A, Spencer B, Rockenstein E, Murphy AN, Ellis RJ, Letendre S, Grant I, Masliah E. HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders. Neurobiology of Disease. PMID 26611103 DOI: 10.1016/J.Nbd.2015.11.015  0.332
2015 Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman RA. Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26555315 DOI: 10.1016/J.Jalz.2015.09.007  0.371
2015 Kohl Z, Abdallah NB, Vogelgsang J, Tischer L, Deusser J, Amato D, Anderson S, Müller CP, Riess O, Masliah E, Nuber S, Winkler J. Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease. Neurobiology of Disease. PMID 26523794 DOI: 10.1016/J.Nbd.2015.10.021  0.379
2015 Valera E, Spencer B, Masliah E. Immunotherapeutic Approaches Targeting Amyloid-β, α-Synuclein, and Tau for the Treatment of Neurodegenerative Disorders. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 26494242 DOI: 10.1007/S13311-015-0397-Z  0.391
2015 Goldberg NR, Caesar J, Park A, Sedgh S, Finogenov G, Masliah E, Davis J, Blurton-Jones M. Neural Stem Cells Rescue Cognitive and Motor Dysfunction in a Transgenic Model of Dementia with Lewy Bodies through a BDNF-Dependent Mechanism. Stem Cell Reports. PMID 26489892 DOI: 10.1016/J.Stemcr.2015.09.008  0.324
2015 Kim C, Rockenstein E, Spencer B, Kim HK, Adame A, Trejo M, Stafa K, Lee HJ, Lee SJ, Masliah E. Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy. Cell Reports. PMID 26489461 DOI: 10.1016/J.Celrep.2015.09.044  0.373
2015 Spencer B, Valera E, Rockenstein E, Trejo-Morales M, Adame A, Masliah E. A brain-targeted, modified neurosin (kallikrein-6) reduces α-synuclein accumulation in a mouse model of multiple system atrophy. Molecular Neurodegeneration. 10: 48. PMID 26394760 DOI: 10.1186/S13024-015-0043-6  0.376
2015 Min SW, Chen X, Tracy TE, Li Y, Zhou Y, Wang C, Shirakawa K, Minami SS, Defensor E, Mok SA, Sohn PD, Schilling B, Cong X, Ellerby L, Gibson BW, ... ... Masliah E, et al. Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits. Nature Medicine. PMID 26390242 DOI: 10.1038/Nm.3951  0.414
2015 Nakanishi N, Kang YJ, Tu S, McKercher SR, Masliah E, Lipton SA. Differential Effects of Pharmacologic and Genetic Modulation of NMDA Receptor Activity on HIV/gp120-Induced Neuronal Damage in an In Vivo Mouse Model. Journal of Molecular Neuroscience : Mn. PMID 26374431 DOI: 10.1007/S12031-015-0651-1  0.344
2015 Overk CR, Rockenstein E, Florio J, Cheng Q, Masliah E. Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. Neuroscience. 310: 549-60. PMID 26341908 DOI: 10.1016/J.Neuroscience.2015.08.068  0.389
2015 Zhao Y, Tseng IC, Heyser CJ, Rockenstein E, Mante M, Adame A, Zheng Q, Huang T, Wang X, Arslan PE, Chakrabarty P, Wu C, Bu G, Mobley WC, Zhang YW, ... ... Masliah E, et al. Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron. 87: 963-75. PMID 26335643 DOI: 10.1016/J.Neuron.2015.08.020  0.388
2015 Tuszynski MH, Yang JH, Barba D, U HS, Bakay RA, Pay MM, Masliah E, Conner JM, Kobalka P, Roy S, Nagahara AH. Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease. Jama Neurology. PMID 26302439 DOI: 10.1001/Jamaneurol.2015.1807  0.673
2015 Rockenstein E, Desplats P, Ubhi K, Mante M, Florio J, Adame A, Winter S, Brandstaetter H, Meier D, Masliah E. Neuro-peptide treatment with Cerebrolysin improves the survival of neural stem cell grafts in an APP transgenic model of Alzheimer disease. Stem Cell Research. 15: 54-67. PMID 26209890 DOI: 10.1016/J.Scr.2015.04.008  0.336
2015 Masliah E, Spencer B. Applications of ApoB LDLR-Binding Domain Approach for the Development of CNS-Penetrating Peptides for Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 1324: 331-7. PMID 26202279 DOI: 10.1007/978-1-4939-2806-4_21  0.318
2015 Deusser J, Schmidt S, Ettle B, Plötz S, Huber S, Müller CP, Masliah E, Winkler J, Kohl Z. Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson's disease. Journal of Neurochemistry. PMID 26201615 DOI: 10.1111/Jnc.13253  0.362
2015 Lee SJ, Masliah E. Neurodegeneration: Aggregates feel the strain. Nature. 522: 296-7. PMID 26061764 DOI: 10.1038/Nature14526  0.334
2015 Valera E, Mante M, Anderson S, Rockenstein E, Masliah E. Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. Journal of Neuroinflammation. 12: 93. PMID 25966683 DOI: 10.1186/S12974-015-0320-X  0.36
2015 Dewji NN, Singer SJ, Masliah E, Rockenstein E, Kim M, Harber M, Horwood T. Peptides of presenilin-1 bind the amyloid precursor protein ectodomain and offer a novel and specific therapeutic approach to reduce ß-amyloid in Alzheimer's disease. Plos One. 10: e0122451. PMID 25923432 DOI: 10.1371/Journal.Pone.0122451  0.369
2015 Mandler M, Valera E, Rockenstein E, Mante M, Weninger H, Patrick C, Adame A, Schmidhuber S, Santic R, Schneeberger A, Schmidt W, Mattner F, Masliah E. Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy. Molecular Neurodegeneration. 10: 10. PMID 25886309 DOI: 10.1186/S13024-015-0008-9  0.355
2015 Zare-Shahabadi A, Masliah E, Johnson GV, Rezaei N. Autophagy in Alzheimer's disease. Reviews in the Neurosciences. PMID 25870960 DOI: 10.1515/Revneuro-2014-0076  0.398
2015 Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E. A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies. Plos One. 10: e0121570. PMID 25803611 DOI: 10.1371/Journal.Pone.0121570  0.405
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.399
2015 Fields JA, Dumaop W, Crews L, Adame A, Spencer B, Metcalf J, He J, Rockenstein E, Masliah E. Mechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disorders. Current Hiv Research. 13: 43-54. PMID 25760044 DOI: 10.2174/1570162X13666150311164201  0.631
2015 Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. Journal of Neurochemistry. 133: 898-908. PMID 25692407 DOI: 10.1111/Jnc.13074  0.31
2015 Dubal DB, Zhu L, Sanchez PE, Worden K, Broestl L, Johnson E, Ho K, Yu GQ, Kim D, Betourne A, Kuro-O M, Masliah E, Abraham CR, Mucke L. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2358-71. PMID 25673831 DOI: 10.1523/Jneurosci.5791-12.2015  0.405
2015 Fields J, Dumaop W, Elueteri S, Campos S, Serger E, Trejo M, Kosberg K, Adame A, Spencer B, Rockenstein E, He JJ, Masliah E. HIV-1 Tat alters neuronal autophagy by modulating autophagosome fusion to the lysosome: implications for HIV-associated neurocognitive disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1921-38. PMID 25653352 DOI: 10.1523/Jneurosci.3207-14.2015  0.341
2015 Orr AG, Hsiao EC, Wang MM, Ho K, Kim DH, Wang X, Guo W, Kang J, Yu GQ, Adame A, Devidze N, Dubal DB, Masliah E, Conklin BR, Mucke L. Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. Nature Neuroscience. 18: 423-34. PMID 25622143 DOI: 10.1038/Nn.3930  0.323
2015 Magen I, Torres ER, Dinh D, Chung A, Masliah E, Chesselet MF. Social Cognition Impairments in Mice Overexpressing Alpha-Synuclein Under the Thy1 Promoter, a Model of Pre-manifest Parkinson's Disease. Journal of Parkinson's Disease. PMID 25588356 DOI: 10.3233/Jpd-140503  0.363
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 85: 76-87. PMID 25533483 DOI: 10.1016/J.Neuron.2014.11.027  0.304
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Masliah E, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.367
2015 Gaffney PM, Barr B, Rowe JD, Bett C, Drygiannakis I, Giannitti F, Trejo M, Ghassemian M, Martin P, Masliah E, Sigurdson CJ. Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 911-9. PMID 25422367 DOI: 10.1096/Fj.14-256081  0.348
2015 Eleuteri S, Di Giovanni S, Rockenstein E, Mante M, Adame A, Trejo M, Wrasidlo W, Wu F, Fraering PC, Masliah E, Lashuel HA. Novel therapeutic strategy for neurodegeneration by blocking Aβ seeding mediated aggregation in models of Alzheimer's disease. Neurobiology of Disease. 74: 144-57. PMID 25173807 DOI: 10.1016/J.Nbd.2014.08.017  0.42
2015 Campbell SN, Zhang C, Monte L, Roe AD, Rice KC, Taché Y, Masliah E, Rissman RA. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. Journal of Alzheimer's Disease : Jad. 43: 967-76. PMID 25125464 DOI: 10.3233/Jad-141281  0.381
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Erratum to Parkinson's Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein [(Neuron 85, (2015) 76-87] Neuron. 85. DOI: 10.1016/J.Neuron.2015.01.022  0.317
2015 Zhang C, Kuo C, Moghadam SH, Campbell S, Monte L, Rice K, Sawchenko P, Masliah E, Rissman R. O2-05-06: Crf receptor 1 antagonism as a disease-modifying therapy for Alzheimer's disease: Preclincal data on pathology and cognitive and synaptic deficits Alzheimer's & Dementia. 11: P185-P185. DOI: 10.1016/J.Jalz.2015.07.483  0.34
2015 Gate D, Doty K, Leung B, Rodriguez J, Masliah E, Town T. O2-14-02: Irak-m removal endorses microglia-mediated amyloid phagocytosis and improves cognitive impairment in psapp mice Alzheimer's & Dementia. 11: P208-P208. DOI: 10.1016/J.Jalz.2015.07.209  0.314
2014 Koob AO, Shaked GM, Bender A, Bisquertt A, Rockenstein E, Masliah E. Neurogranin binds α-synuclein in the human superior temporal cortex and interaction is decreased in Parkinson's disease. Brain Research. 1591: 102-10. PMID 25446004 DOI: 10.1016/J.Brainres.2014.10.013  0.728
2014 Gaffney PM, Imai DM, Clifford DL, Ghassemian M, Sasik R, Chang AN, O'Brien TD, Coppinger J, Trejo M, Masliah E, Munson L, Sigurdson C. Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes. Plos One. 9: e113765. PMID 25429466 DOI: 10.1371/Journal.Pone.0113765  0.325
2014 Tank J, da Costa-Goncalves AC, Kamer I, Qadri F, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Gross V, Jordan J. Preserved functional autonomic phenotype in adult mice overexpressing moderate levels of human alpha-synuclein in oligodendrocytes. Physiological Reports. 2. PMID 25428949 DOI: 10.14814/Phy2.12209  0.339
2014 Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE. Modulation of the maladaptive stress response to manage diseases of protein folding. Plos Biology. 12: e1001998. PMID 25406061 DOI: 10.1371/Journal.Pbio.1001998  0.364
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... ... Masliah E, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.611
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Masliah E, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.304
2014 Bae EJ, Yang NY, Song M, Lee CS, Lee JS, Jung BC, Lee HJ, Kim S, Masliah E, Sardi SP, Lee SJ. Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein. Nature Communications. 5: 4755. PMID 25156829 DOI: 10.1038/Ncomms5755  0.315
2014 Sekiyama K, Waragai M, Akatsu H, Sugama S, Takenouchi T, Takamatsu Y, Fujita M, Sekigawa A, Rockenstein E, Inoue S, La Spada AR, Masliah E, Hashimoto M. Disease-Modifying Effect of Adiponectin in Model of α-Synucleinopathies. Annals of Clinical and Translational Neurology. 1: 479-489. PMID 25126588 DOI: 10.1002/Acn3.77  0.409
2014 Wrasidlo W, Crews LA, Tsigelny IF, Stocking E, Kouznetsova VL, Price D, Paulino A, Gonzales T, Overk CR, Patrick C, Rockenstein E, Masliah E. Neuroprotective effects of the anti-cancer drug sunitinib in models of HIV neurotoxicity suggests potential for the treatment of neurodegenerative disorders. British Journal of Pharmacology. 171: 5757-73. PMID 25117211 DOI: 10.1111/Bph.12875  0.602
2014 Rockenstein E, Ubhi K, Trejo M, Mante M, Patrick C, Adame A, Novak P, Jech M, Doppler E, Moessler H, Masliah E. Cerebrolysinâ„¢ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure. Bmc Neuroscience. 15: 90. PMID 25047000 DOI: 10.1186/1471-2202-15-90  0.429
2014 Blurton-Jones M, Spencer B, Michael S, Castello NA, Agazaryan AA, Davis JL, Müller FJ, Loring JF, Masliah E, LaFerla FM. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models. Stem Cell Research & Therapy. 5: 46. PMID 25022790 DOI: 10.1186/Scrt440  0.417
2014 Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E. Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9441-54. PMID 25009275 DOI: 10.1523/Jneurosci.5314-13.2014  0.317
2014 Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E. ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 1753-67. PMID 25008355 DOI: 10.1038/Mt.2014.129  0.362
2014 Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Molecular Neurodegeneration. 9: 26. PMID 24980976 DOI: 10.1186/1750-1326-9-26  0.307
2014 Grosso H, Woo JM, Lee KW, Im JY, Masliah E, Junn E, Mouradian MM. Transglutaminase 2 exacerbates α-synuclein toxicity in mice and yeast. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4280-91. PMID 24970392 DOI: 10.1096/Fj.14-251413  0.368
2014 Spencer B, Masliah E. Immunotherapy for Alzheimer's disease: past, present and future. Frontiers in Aging Neuroscience. 6: 114. PMID 24959143 DOI: 10.3389/Fnagi.2014.00114  0.362
2014 Buxbaum JN, Roberts AJ, Adame A, Masliah E. Silencing of murine transthyretin and retinol binding protein genes has distinct and shared behavioral and neuropathologic effects. Neuroscience. 275: 352-64. PMID 24956283 DOI: 10.1016/J.Neuroscience.2014.06.019  0.308
2014 Overk CR, Cartier A, Shaked G, Rockenstein E, Ubhi K, Spencer B, Price DL, Patrick C, Desplats P, Masliah E. Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies. Molecular Neurodegeneration. 9: 18. PMID 24885390 DOI: 10.1186/1750-1326-9-18  0.397
2014 Spencer B, Verma I, Desplats P, Morvinski D, Rockenstein E, Adame A, Masliah E. A neuroprotective brain-penetrating endopeptidase fusion protein ameliorates Alzheimer disease pathology and restores neurogenesis. The Journal of Biological Chemistry. 289: 17917-31. PMID 24825898 DOI: 10.1074/Jbc.M114.557439  0.41
2014 Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Gerez J, Picotti P, Jensen PH, Campioni S, Riek R, Winkler J, Gage FH, ... ... Masliah E, et al. Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo. Brain : a Journal of Neurology. 137: 1496-513. PMID 24662516 DOI: 10.1093/Brain/Awu057  0.419
2014 Bae EJ, Lee HJ, Jang YH, Michael S, Masliah E, Min DS, Lee SJ. Phospholipase D1 regulates autophagic flux and clearance of α-synuclein aggregates. Cell Death and Differentiation. 21: 1132-41. PMID 24632948 DOI: 10.1038/Cdd.2014.30  0.408
2014 Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, et al. Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice. Human Molecular Genetics. 23: 3975-89. PMID 24619358 DOI: 10.1093/Hmg/Ddu112  0.418
2014 Avraham HK, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Wood J, Wang L, Masliah E, Avraham S. Impaired Neurogenesis by HIV-1-Gp120 is Rescued by genetic deletion of Fatty Acid Amide Hydrolase Enzyme. British Journal of Pharmacology. PMID 24571443 DOI: 10.1111/Bph.12657  0.345
2014 Mandler M, Valera E, Rockenstein E, Weninger H, Patrick C, Adame A, Santic R, Meindl S, Vigl B, Smrzka O, Schneeberger A, Mattner F, Masliah E. Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials. Acta Neuropathologica. 127: 861-79. PMID 24525765 DOI: 10.1007/S00401-014-1256-4  0.319
2014 Nuber S, Tadros D, Fields J, Overk CR, Ettle B, Kosberg K, Mante M, Rockenstein E, Trejo M, Masliah E. Environmental neurotoxic challenge of conditional alpha-synuclein transgenic mice predicts a dopaminergic olfactory-striatal interplay in early PD. Acta Neuropathologica. 127: 477-94. PMID 24509835 DOI: 10.1007/S00401-014-1255-5  0.362
2014 Mahul-Mellier AL, Fauvet B, Gysbers A, Dikiy I, Oueslati A, Georgeon S, Lamontanara AJ, Bisquertt A, Eliezer D, Masliah E, Halliday G, Hantschel O, Lashuel HA. c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Human Molecular Genetics. 23: 2858-79. PMID 24412932 DOI: 10.1093/Hmg/Ddt674  0.313
2014 Joshi-Barr S, Bett C, Chiang WC, Trejo M, Goebel HH, Sikorska B, Liberski P, Raeber A, Lin JH, Masliah E, Sigurdson CJ. De novo prion aggregates trigger autophagy in skeletal muscle. Journal of Virology. 88: 2071-82. PMID 24307586 DOI: 10.1128/Jvi.02279-13  0.341
2014 Tsigelny IF, Sharikov Y, Kouznetsova VL, Greenberg JP, Wrasidlo W, Gonzalez T, Desplats P, Michael SE, Trejo-Morales M, Overk CR, Masliah E. Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation. Journal of Alzheimer's Disease : Jad. 39: 583-600. PMID 24240640 DOI: 10.3233/Jad-131589  0.327
2014 Avraham HK, Jiang S, Fu Y, Rockenstein E, Makriyannis A, Zvonok A, Masliah E, Avraham S. The cannabinoid CBâ‚‚ receptor agonist AM1241 enhances neurogenesis in GFAP/Gp120 transgenic mice displaying deficits in neurogenesis. British Journal of Pharmacology. 171: 468-79. PMID 24148086 DOI: 10.1111/Bph.12478  0.347
2014 Vázquez-Roque RA, Ubhi K, Masliah E, Flores G. Chronic cerebrolysin administration attenuates neuronal abnormalities in the basolateral amygdala induced by neonatal ventral hippocampus lesion in the rat. Synapse (New York, N.Y.). 68: 31-8. PMID 24123373 DOI: 10.1002/Syn.21718  0.312
2014 Carbone I, Lazzarotto T, Ianni M, Porcellini E, Forti P, Masliah E, Gabrielli L, Licastro F. Herpes virus in Alzheimer's disease: relation to progression of the disease. Neurobiology of Aging. 35: 122-9. PMID 23916950 DOI: 10.1016/J.Neurobiolaging.2013.06.024  0.345
2014 Hamilton JM, Salmon DP, Raman R, Hansen LA, Masliah E, Peavy GM, Galasko D. Accounting for functional loss in Alzheimer's disease and dementia with Lewy bodies: beyond cognition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 171-8. PMID 23850331 DOI: 10.1016/J.Jalz.2013.04.003  0.305
2014 Gate D, Rodriguez J, Leung B, Masliah E, Town T. O3-12-02: IRAK-M DELETION PROMOTES MICROGLIA-MEDIATED Aβ PHAGOCYTOSIS AND IMPROVES COGNITION IN PSAPP MICE Alzheimer's & Dementia. 10: P233-P233. DOI: 10.1016/J.Jalz.2014.04.336  0.31
2013 Fields J, Dumaop W, Adame A, Ellis RJ, Letendre S, Grant I, Masliah E. Alterations in the levels of vesicular trafficking proteins involved in HIV replication in the brains and CSF of patients with HIV-associated neurocognitive disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 1197-209. PMID 24292993 DOI: 10.1007/S11481-013-9511-3  0.318
2013 Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, ... ... Masliah E, et al. Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1α transcription. Cell. 155: 1351-64. PMID 24290359 DOI: 10.1016/J.Cell.2013.11.009  0.306
2013 Duka V, Lee JH, Credle J, Wills J, Oaks A, Smolinsky C, Shah K, Mash DC, Masliah E, Sidhu A. Identification of the sites of tau hyperphosphorylation and activation of tau kinases in synucleinopathies and Alzheimer's diseases. Plos One. 8: e75025. PMID 24073234 DOI: 10.1371/Journal.Pone.0075025  0.367
2013 Nagahara AH, Mateling M, Kovacs I, Wang L, Eggert S, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 15596-602. PMID 24068826 DOI: 10.1523/Jneurosci.5195-12.2013  0.419
2013 Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Abbey RJ, Mastroeni DF, Rogers J, Spencer B, Masliah E, Wyss-Coray T. Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron. 79: 873-86. PMID 24012002 DOI: 10.1016/J.Neuron.2013.06.046  0.406
2013 Sunico CR, Nakamura T, Rockenstein E, Mante M, Adame A, Chan SF, Newmeyer TF, Masliah E, Nakanishi N, Lipton SA. S-Nitrosylation of parkin as a novel regulator of p53-mediated neuronal cell death in sporadic Parkinson's disease. Molecular Neurodegeneration. 8: 29. PMID 23985028 DOI: 10.1186/1750-1326-8-29  0.328
2013 Fleming SM, Jordan MC, Mulligan CK, Masliah E, Holden JG, Millard RW, Chesselet MF, Roos KP. Impaired baroreflex function in mice overexpressing alpha-synuclein. Frontiers in Neurology. 4: 103. PMID 23888153 DOI: 10.3389/Fneur.2013.00103  0.338
2013 Marxreiter F, Ettle B, May VE, Esmer H, Patrick C, Kragh CL, Klucken J, Winner B, Riess O, Winkler J, Masliah E, Nuber S. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiology of Disease. 59: 38-51. PMID 23867236 DOI: 10.1016/J.Nbd.2013.07.004  0.382
2013 Sekigawa A, Sekiyama K, Fujita M, Takamatsu Y, La Spada AR, Masliah E, Hashimoto M. Dual effects of β-synuclein on the pathogenesis of Parkinson disease. Annals of Neurology. 74: 306. PMID 23836414 DOI: 10.1002/Ana.23936  0.323
2013 Talantova M, Sanz-Blasco S, Zhang X, Xia P, Akhtar MW, Okamoto S, Dziewczapolski G, Nakamura T, Cao G, Pratt AE, Kang YJ, Tu S, Molokanova E, McKercher SR, Hires SA, ... ... Masliah E, et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss. Proceedings of the National Academy of Sciences of the United States of America. 110: E2518-27. PMID 23776240 DOI: 10.1073/Pnas.1306832110  0.368
2013 Sarafian TA, Ryan CM, Souda P, Masliah E, Kar UK, Vinters HV, Mathern GW, Faull KF, Whitelegge JP, Watson JB. Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein. Plos One. 8: e63557. PMID 23667637 DOI: 10.1371/Journal.Pone.0063557  0.333
2013 Bett C, Kurt TD, Lucero M, Trejo M, Rozemuller AJ, Kong Q, Nilsson KP, Masliah E, Oldstone MB, Sigurdson CJ. Defining the conformational features of anchorless, poorly neuroinvasive prions. Plos Pathogens. 9: e1003280. PMID 23637596 DOI: 10.1371/Journal.Ppat.1003280  0.371
2013 Shaltiel-Karyo R, Frenkel-Pinter M, Rockenstein E, Patrick C, Levy-Sakin M, Schiller A, Egoz-Matia N, Masliah E, Segal D, Gazit E. A blood-brain barrier (BBB) disrupter is also a potent α-synuclein (α-syn) aggregation inhibitor: a novel dual mechanism of mannitol for the treatment of Parkinson disease (PD). The Journal of Biological Chemistry. 288: 17579-88. PMID 23637226 DOI: 10.1074/Jbc.M112.434787  0.376
2013 Bender A, Desplats P, Spencer B, Rockenstein E, Adame A, Elstner M, Laub C, Mueller S, Koob AO, Mante M, Pham E, Klopstock T, Masliah E. TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease. Plos One. 8: e62277. PMID 23626796 DOI: 10.1371/Journal.Pone.0062277  0.734
2013 Peavy GM, Salmon DP, Edland SD, Tam S, Hansen LA, Masliah E, Galasko D, Hamilton JM. Neuropsychiatric features of frontal lobe dysfunction in autopsy-confirmed patients with lewy bodies and "pure" Alzheimer disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 21: 509-19. PMID 23567425 DOI: 10.1016/J.Jagp.2012.10.022  0.338
2013 Kim C, Ho DH, Suk JE, You S, Michael S, Kang J, Joong Lee S, Masliah E, Hwang D, Lee HJ, Lee SJ. Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia. Nature Communications. 4: 1562. PMID 23463005 DOI: 10.1038/Ncomms2534  0.357
2013 Nuber S, Harmuth F, Kohl Z, Adame A, Trejo M, Schönig K, Zimmermann F, Bauer C, Casadei N, Giel C, Calaminus C, Pichler BJ, Jensen PH, Müller CP, Amato D, ... ... Masliah E, et al. A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. Brain : a Journal of Neurology. 136: 412-32. PMID 23413261 DOI: 10.1093/Brain/Aws358  0.392
2013 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Trojanowski JQ, Weintraub D, Chen-Plotkin AS, ... ... Masliah E, et al. APOE ε4 increases risk for dementia in pure synucleinopathies. Jama Neurology. 70: 223-8. PMID 23407718 DOI: 10.1001/Jamaneurol.2013.600  0.339
2013 Boassa D, Berlanga ML, Yang MA, Terada M, Hu J, Bushong EA, Hwang M, Masliah E, George JM, Ellisman MH. Mapping the subcellular distribution of α-synuclein in neurons using genetically encoded probes for correlated light and electron microscopy: implications for Parkinson's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2605-15. PMID 23392688 DOI: 10.1523/Jneurosci.2898-12.2013  0.373
2013 Fields J, Dumaop W, Rockenstein E, Mante M, Spencer B, Grant I, Ellis R, Letendre S, Patrick C, Adame A, Masliah E. Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer. Journal of Neurovirology. 19: 89-101. PMID 23341224 DOI: 10.1007/S13365-012-0145-7  0.344
2013 Morris M, Hamto P, Adame A, Devidze N, Masliah E, Mucke L. Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice. Neurobiology of Aging. 34: 1523-9. PMID 23332171 DOI: 10.1016/J.Neurobiolaging.2012.12.003  0.373
2013 Games D, Seubert P, Rockenstein E, Patrick C, Trejo M, Ubhi K, Ettle B, Ghassemiam M, Barbour R, Schenk D, Nuber S, Masliah E. Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein. The American Journal of Pathology. 182: 940-53. PMID 23313024 DOI: 10.1016/J.Ajpath.2012.11.018  0.367
2013 Amschl D, Neddens J, Havas D, Flunkert S, Rabl R, Römer H, Rockenstein E, Masliah E, Windisch M, Hutter-Paier B. Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model. Bmc Neuroscience. 14: 6. PMID 23302418 DOI: 10.1186/1471-2202-14-6  0.429
2013 Lashuel HA, Overk CR, Oueslati A, Masliah E. The many faces of α-synuclein: from structure and toxicity to therapeutic target. Nature Reviews. Neuroscience. 14: 38-48. PMID 23254192 DOI: 10.1038/Nrn3406  0.346
2013 Huang TY, Michael S, Xu T, Sarkeshik A, Moresco JJ, Yates JR, Masliah E, Bokoch GM, DerMardirossian C. A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation. Molecular Biology of the Cell. 24: 194-209. PMID 23223568 DOI: 10.1091/Mbc.E12-07-0565  0.339
2013 Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E, Walsh DM. Alzheimer brain-derived amyloid β-protein impairs synaptic remodeling and memory consolidation. Neurobiology of Aging. 34: 1315-27. PMID 23182244 DOI: 10.1016/J.Neurobiolaging.2012.10.028  0.365
2013 Ubhi K, Rockenstein E, Vazquez-Roque R, Mante M, Inglis C, Patrick C, Adame A, Fahnestock M, Doppler E, Novak P, Moessler H, Masliah E. Cerebrolysin modulates pronerve growth factor/nerve growth factor ratio and ameliorates the cholinergic deficit in a transgenic model of Alzheimer's disease. Journal of Neuroscience Research. 91: 167-77. PMID 23152192 DOI: 10.1002/Jnr.23142  0.39
2013 Sherzai A, Edland SD, Masliah E, Hansen L, Pizzo DP, Sherzai A, Corey-Bloom J. Spongiform change in dementia with Lewy bodies and Alzheimer disease. Alzheimer Disease and Associated Disorders. 27: 157-61. PMID 22546782 DOI: 10.1097/Wad.0B013E318256D507  0.369
2013 Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, Adame A, Masliah E. Lentivirus mediated delivery of neurosin promotes clearance of wild-type α-synuclein and reduces the pathology in an α-synuclein model of LBD. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 31-41. PMID 22508489 DOI: 10.1038/Mt.2012.66  0.407
2013 Gate D, Kim G, Breunig J, Masliah E, Town T. P1-026: IRAK-M deletion promotes microglia-mediated beta-amyloid phagocytosis in PSAPP mice Alzheimer's & Dementia. 9: P161-P162. DOI: 10.1016/J.Jalz.2013.05.246  0.326
2013 Masliah E, Rockenstein E, Fisher R, Levenson J, Gannon K. P4-287: A general amyloid interaction motif (GAIM) approach to targeting multiple types of misfolded protein deposits in models of neurodegenerative disease Alzheimer's & Dementia. 9: P809-P809. DOI: 10.1016/J.Jalz.2013.05.1680  0.335
2012 Winner B, Regensburger M, Schreglmann S, Boyer L, Prots I, Rockenstein E, Mante M, Zhao C, Winkler J, Masliah E, Gage FH. Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16906-16. PMID 23175842 DOI: 10.1523/Jneurosci.2723-12.2012  0.4
2012 Zhang H, Zhang YW, Chen Y, Huang X, Zhou F, Wang W, Xian B, Zhang X, Masliah E, Chen Q, Han JD, Bu G, Reed JC, Liao FF, Chen YG, et al. Appoptosin is a novel pro-apoptotic protein and mediates cell death in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15565-76. PMID 23115192 DOI: 10.1523/Jneurosci.3668-12.2012  0.343
2012 Gelman BB, Chen T, Lisinicchia JG, Soukup VM, Carmical JR, Starkey JM, Masliah E, Commins DL, Brandt D, Grant I, Singer EJ, Levine AJ, Miller J, Winkler JM, Fox HS, et al. The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment. Plos One. 7: e46178. PMID 23049970 DOI: 10.1371/Journal.Pone.0046178  0.322
2012 Tsuang D, Leverenz JB, Lopez OL, Hamilton RL, Bennett DA, Schneider JA, Buchman AS, Larson EB, Crane PK, Kaye JA, Kramer P, Woltjer R, Kukull W, Nelson PT, Jicha GA, ... ... Masliah E, et al. GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology. Neurology. 79: 1944-50. PMID 23035075 DOI: 10.1212/Wnl.0B013E3182735E9A  0.356
2012 Harris JA, Koyama A, Maeda S, Ho K, Devidze N, Dubal DB, Yu GQ, Masliah E, Mucke L. Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits. Plos One. 7: e45881. PMID 23029293 DOI: 10.1371/Journal.Pone.0045881  0.438
2012 Soontornniyomkij V, Moore DJ, Gouaux B, Soontornniyomkij B, Tatro ET, Umlauf A, Masliah E, Levine AJ, Singer EJ, Vinters HV, Gelman BB, Morgello S, Cherner M, Grant I, Achim CL. Cerebral β-amyloid deposition predicts HIV-associated neurocognitive disorders in APOE ε4 carriers. Aids (London, England). 26: 2327-35. PMID 23018443 DOI: 10.1097/Qad.0B013E32835A117C  0.366
2012 Desplats P, Patel P, Kosberg K, Mante M, Patrick C, Rockenstein E, Fujita M, Hashimoto M, Masliah E. Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease. Molecular Neurodegeneration. 7: 49. PMID 23017109 DOI: 10.1186/1750-1326-7-49  0.337
2012 Bae EJ, Lee HJ, Rockenstein E, Ho DH, Park EB, Yang NY, Desplats P, Masliah E, Lee SJ. Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13454-69. PMID 23015436 DOI: 10.1523/Jneurosci.1292-12.2012  0.396
2012 Sekigawa A, Fujita M, Sekiyama K, Takamatsu Y, Hatano T, Rockenstein E, La Spada AR, Masliah E, Hashimoto M. Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein. Molecular Brain. 5: 34. PMID 23013868 DOI: 10.1186/1756-6606-5-34  0.323
2012 Britschgi M, Takeda-Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss-Coray T. Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice. Journal of Neuroinflammation. 9: 220. PMID 22989354 DOI: 10.1186/1742-2094-9-220  0.437
2012 Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/Jneurosci.0757-12.2012  0.4
2012 Kwak YD, Wang B, Li JJ, Wang R, Deng Q, Diao S, Chen Y, Xu R, Masliah E, Xu H, Sung JJ, Liao FF. Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10971-81. PMID 22875931 DOI: 10.1523/Jneurosci.1836-12.2012  0.356
2012 Siggs OM, Cruite JT, Du X, Rutschmann S, Masliah E, Beutler B, Oldstone MB. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease. Proceedings of the National Academy of Sciences of the United States of America. 109: 13733-8. PMID 22869751 DOI: 10.1073/Pnas.1211499109  0.33
2012 Hafez DM, Huang JY, Richardson JC, Masliah E, Peterson DA, Marr RA. F-spondin gene transfer improves memory performance and reduces amyloid-β levels in mice. Neuroscience. 223: 465-72. PMID 22863679 DOI: 10.1016/J.Neuroscience.2012.07.038  0.381
2012 Desplats P, Spencer B, Crews L, Pathel P, Morvinski-Friedmann D, Kosberg K, Roberts S, Patrick C, Winner B, Winkler J, Masliah E. α-Synuclein induces alterations in adult neurogenesis in Parkinson disease models via p53-mediated repression of Notch1. The Journal of Biological Chemistry. 287: 31691-702. PMID 22833673 DOI: 10.1074/Jbc.M112.354522  0.636
2012 Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. In vivo alterations in calcium buffering capacity in transgenic mouse model of synucleinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9992-8. PMID 22815513 DOI: 10.1523/Jneurosci.1270-12.2012  0.332
2012 Tsunemi T, Ashe TD, Morrison BE, Soriano KR, Au J, Roque RA, Lazarowski ER, Damian VA, Masliah E, La Spada AR. PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function. Science Translational Medicine. 4: 142ra97. PMID 22786682 DOI: 10.1126/Scitranslmed.3003799  0.336
2012 Watson MB, Richter F, Lee SK, Gabby L, Wu J, Masliah E, Effros RB, Chesselet MF. Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein. Experimental Neurology. 237: 318-34. PMID 22750327 DOI: 10.1016/J.Expneurol.2012.06.025  0.368
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Masliah E, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.505
2012 Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 8: 754-66. PMID 22647715 DOI: 10.4161/Auto.19371  0.386
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Masliah E, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.368
2012 Verret L, Mann EO, Hang GB, Barth AM, Cobos I, Ho K, Devidze N, Masliah E, Kreitzer AC, Mody I, Mucke L, Palop JJ. Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model. Cell. 149: 708-21. PMID 22541439 DOI: 10.1016/J.Cell.2012.02.046  0.39
2012 Lee SJ, Desplats P, Lee HJ, Spencer B, Masliah E. Cell-to-cell transmission of α-synuclein aggregates. Methods in Molecular Biology (Clifton, N.J.). 849: 347-59. PMID 22528101 DOI: 10.1007/978-1-61779-551-0_23  0.364
2012 Cartier AE, Ubhi K, Spencer B, Vazquez-Roque RA, Kosberg KA, Fourgeaud L, Kanayson P, Patrick C, Rockenstein E, Patrick GN, Masliah E. Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy. Plos One. 7: e34713. PMID 22514658 DOI: 10.1371/Journal.Pone.0034713  0.367
2012 Tang B, Becanovic K, Desplats PA, Spencer B, Hill AM, Connolly C, Masliah E, Leavitt BR, Thomas EA. Forkhead box protein p1 is a transcriptional repressor of immune signaling in the CNS: implications for transcriptional dysregulation in Huntington disease. Human Molecular Genetics. 21: 3097-111. PMID 22492998 DOI: 10.1093/Hmg/Dds132  0.347
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Masliah E, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.366
2012 Masliah E, Rockenstein E, Inglis C, Adame A, Bett C, Lucero M, Sigurdson CJ. Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice. Prion. 6: 184-90. PMID 22460692 DOI: 10.4161/Pri.19806  0.419
2012 Soontornniyomkij V, Soontornniyomkij B, Moore DJ, Gouaux B, Masliah E, Tung S, Vinters HV, Grant I, Achim CL. Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 579-90. PMID 22450766 DOI: 10.1007/S11481-012-9357-0  0.368
2012 Koob AO, Bruns L, Prassler C, Masliah E, Klopstock T, Bender A. Protein analysis through Western blot of cells excised individually from human brain and muscle tissue. Analytical Biochemistry. 425: 120-4. PMID 22402104 DOI: 10.1016/J.Ab.2012.02.034  0.696
2012 Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context. Human Molecular Genetics. 21: 2432-49. PMID 22357655 DOI: 10.1093/Hmg/Dds058  0.357
2012 Magen I, Fleming SM, Zhu C, Garcia EC, Cardiff KM, Dinh D, De La Rosa K, Sanchez M, Torres ER, Masliah E, Jentsch JD, Chesselet MF. Cognitive deficits in a mouse model of pre-manifest Parkinson's disease. The European Journal of Neuroscience. 35: 870-82. PMID 22356593 DOI: 10.1111/J.1460-9568.2012.08012.X  0.334
2012 Fauvet B, Mbefo MK, Fares MB, Desobry C, Michael S, Ardah MT, Tsika E, Coune P, Prudent M, Lion N, Eliezer D, Moore DJ, Schneider B, Aebischer P, El-Agnaf OM, ... Masliah E, et al. α-Synuclein in central nervous system and from erythrocytes, mammalian cells, and Escherichia coli exists predominantly as disordered monomer. The Journal of Biological Chemistry. 287: 15345-64. PMID 22315227 DOI: 10.1074/Jbc.M111.318949  0.31
2012 Ubhi K, Inglis C, Mante M, Patrick C, Adame A, Spencer B, Rockenstein E, May V, Winkler J, Masliah E. Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy. Experimental Neurology. 234: 405-16. PMID 22281106 DOI: 10.1016/J.Expneurol.2012.01.008  0.401
2012 Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 1-13. PMID 22265587 DOI: 10.1016/J.Jalz.2011.10.007  0.395
2012 Tsigelny IF, Sharikov Y, Wrasidlo W, Gonzalez T, Desplats PA, Crews L, Spencer B, Masliah E. Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation. The Febs Journal. 279: 1000-13. PMID 22251432 DOI: 10.1111/J.1742-4658.2012.08489.X  0.611
2012 Kwan W, Magnusson A, Chou A, Adame A, Carson MJ, Kohsaka S, Masliah E, Möller T, Ransohoff R, Tabrizi SJ, Björkqvist M, Muchowski PJ. Bone marrow transplantation confers modest benefits in mouse models of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 133-42. PMID 22219276 DOI: 10.1523/Jneurosci.4846-11.2012  0.321
2012 Kohl Z, Winner B, Ubhi K, Rockenstein E, Mante M, Münch M, Barlow C, Carter T, Masliah E, Winkler J. Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model. The European Journal of Neuroscience. 35: 10-9. PMID 22211740 DOI: 10.1111/J.1460-9568.2011.07933.X  0.367
2012 Jolivalt CG, Calcutt NA, Masliah E. Similar pattern of peripheral neuropathy in mouse models of type 1 diabetes and Alzheimer's disease. Neuroscience. 202: 405-12. PMID 22178988 DOI: 10.1016/J.Neuroscience.2011.11.032  0.347
2012 Kragh CL, Ubhi K, Wyss-Coray T, Wyss-Corey T, Masliah E. Autophagy in dementias. Brain Pathology (Zurich, Switzerland). 22: 99-109. PMID 22150925 DOI: 10.1111/J.1750-3639.2011.00545.X  0.366
2012 Masliah E, Hansen LA. Alzheimer disease: AD pathology--emerging subtypes or age-of-onset spectrum? Nature Reviews. Neurology. 8: 11-2. PMID 22143361 DOI: 10.1038/Nrneurol.2011.205  0.349
2012 Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathologica. 123: 1-11. PMID 22101365 DOI: 10.1007/S00401-011-0910-3  0.394
2012 Mandler M, Rockenstein E, Ubhi K, Hansen L, Adame A, Michael S, Galasko D, Santic R, Mattner F, Masliah E. Detection of peri-synaptic amyloid-β pyroglutamate aggregates in early stages of Alzheimer's disease and in AβPP transgenic mice using a novel monoclonal antibody. Journal of Alzheimer's Disease : Jad. 28: 783-94. PMID 22064070 DOI: 10.3233/Jad-2011-111208  0.432
2012 Hamilton JM, Landy KM, Salmon DP, Hansen LA, Masliah E, Galasko D. Early visuospatial deficits predict the occurrence of visual hallucinations in autopsy-confirmed dementia with Lewy bodies. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 20: 773-81. PMID 21997600 DOI: 10.1097/Jgp.0B013E31823033Bc  0.327
2012 Vázquez-Roque RA, Ramos B, Tecuatl C, Juárez I, Adame A, de la Cruz F, Zamudio S, Mena R, Rockenstein E, Masliah E, Flores G. Chronic administration of the neurotrophic agent cerebrolysin ameliorates the behavioral and morphological changes induced by neonatal ventral hippocampus lesion in a rat model of schizophrenia. Journal of Neuroscience Research. 90: 288-306. PMID 21932359 DOI: 10.1002/Jnr.22753  0.301
2012 Price D, Wrasidlo W, Tsigelny I, Bonhaus D, Paulino A, Mante M, Inglis C, Adame A, Moessler H, Rockenstein E, Masliah E. P1-218: Neuroprotective effects of a novel Aß-protein stabilizer in APP transgenic mouse model of Alzheimer's disease Alzheimer's & Dementia. 8: P183-P184. DOI: 10.1016/J.Jalz.2012.05.497  0.39
2012 Cantuti-Castelvetri I, Gannon K, Veinbergs I, Rassoulpour A, Gannon K, Rockenstein E, Masliah E. P1-342: NPT002 reduces beta-amyloid aggregates and improves cognitive performance in aged TG2576 mice Alzheimer's & Dementia. 8: P226-P226. DOI: 10.1016/J.Jalz.2012.05.2028  0.726
2012 Gate D, Rezai-Zadeh K, Masliah E, Town T. O4-07-01: IRAK-M deletion promotes microglia-mediated cerebral amyloid clearance in PSAPP mice Alzheimer's & Dementia. 8: P627-P627. DOI: 10.1016/J.Jalz.2012.05.1671  0.316
2012 Reznichenko L, Cheng Q, Nizar K, Gratiy SL, Saisan PA, Rockenstein EM, González T, Patrick C, Spencer B, Desplats P, Dale AM, Devor A, Masliah E. Increased Calcium Influx and Decreased Buffering Capacity of Intracellular Stores Underlie Neuropathology Induced by Over-Expression of α-Synuclein Biophysical Journal. 102: 424a-425a. DOI: 10.1016/J.Bpj.2011.11.2321  0.315
2012 Ubhi K, Crews L, Masliah E. Alpha-Synuclein and Neurodegeneration Primer On the Autonomic Nervous System. 303-305. DOI: 10.1016/B978-0-12-386525-0.00063-9  0.561
2011 Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 1: a006189. PMID 22229116 DOI: 10.1101/Cshperspect.A006189  0.419
2011 Morris M, Koyama A, Masliah E, Mucke L. Tau reduction does not prevent motor deficits in two mouse models of Parkinson's disease. Plos One. 6: e29257. PMID 22206005 DOI: 10.1371/Journal.Pone.0029257  0.414
2011 Elstner M, Müller SK, Leidolt L, Laub C, Krieg L, Schlaudraff F, Liss B, Morris C, Turnbull DM, Masliah E, Prokisch H, Klopstock T, Bender A. Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions. Molecular Brain. 4: 43. PMID 22188897 DOI: 10.1186/1756-6606-4-43  0.323
2011 Cabeza-Arvelaiz Y, Fleming SM, Richter F, Masliah E, Chesselet MF, Schiestl RH. Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons. Molecular Neurodegeneration. 6: 83. PMID 22165993 DOI: 10.1186/1750-1326-6-83  0.399
2011 Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, ... ... Masliah E, et al. Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nature Chemical Biology. 7: 925-34. PMID 22037470 DOI: 10.1038/Nchembio.694  0.309
2011 Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, Hyman BT, McLean PJ, Unni VK. Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14508-20. PMID 21994367 DOI: 10.1523/Jneurosci.1560-11.2011  0.407
2011 Crews L, Ruf R, Patrick C, Dumaop W, Trejo-Morales M, Achim CL, Rockenstein E, Masliah E. Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders. Molecular Neurodegeneration. 6: 67. PMID 21943307 DOI: 10.1186/1750-1326-6-67  0.65
2011 Cho EG, Zaremba JD, McKercher SR, Talantova M, Tu S, Masliah E, Chan SF, Nakanishi N, Terskikh A, Lipton SA. MEF2C enhances dopaminergic neuron differentiation of human embryonic stem cells in a parkinsonian rat model. Plos One. 6: e24027. PMID 21901155 DOI: 10.1371/Journal.Pone.0024027  0.315
2011 Rockenstein E, Ubhi K, Doppler E, Novak P, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Crews L, Masliah E. Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice. Journal of Alzheimer's Disease : Jad. 27: 743-52. PMID 21860085 DOI: 10.3233/Jad-2011-110914  0.636
2011 Kaul T, Credle J, Haggerty T, Oaks AW, Masliah E, Sidhu A. Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease. Bmc Neuroscience. 12: 79. PMID 21812967 DOI: 10.1186/1471-2202-12-79  0.335
2011 Rockenstein E, Ubhi K, Pham E, Michael S, Doppler E, Novak P, Inglis C, Mante M, Adame A, Alvarez XA, Moessler H, Masliah E. Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease. Journal of Neuroscience Research. 89: 1812-21. PMID 21793038 DOI: 10.1002/Jnr.22712  0.406
2011 Ho GJ, Liang W, Waragai M, Sekiyama K, Masliah E, Hashimoto M. Bridging molecular genetics and biomarkers in lewy body and related disorders. International Journal of Alzheimer's Disease. 2011: 842475. PMID 21760990 DOI: 10.4061/2011/842475  0.337
2011 Paulino AD, Ubhi K, Rockenstein E, Adame A, Crews L, Letendre S, Ellis R, Everall IP, Grant I, Masliah E. Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling. Journal of Neurovirology. 17: 327-40. PMID 21660601 DOI: 10.1007/S13365-011-0039-0  0.593
2011 Zwilling D, Huang SY, Sathyasaikumar KV, Notarangelo FM, Guidetti P, Wu HQ, Lee J, Truong J, Andrews-Zwilling Y, Hsieh EW, Louie JY, Wu T, Scearce-Levie K, Patrick C, Adame A, ... ... Masliah E, et al. Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration. Cell. 145: 863-74. PMID 21640374 DOI: 10.1016/J.Cell.2011.05.020  0.373
2011 Lee SJ, Lim HS, Masliah E, Lee HJ. Protein aggregate spreading in neurodegenerative diseases: problems and perspectives. Neuroscience Research. 70: 339-48. PMID 21624403 DOI: 10.1016/J.Neures.2011.05.008  0.387
2011 Meng F, Yao D, Shi Y, Kabakoff J, Wu W, Reicher J, Ma Y, Moosmann B, Masliah E, Lipton SA, Gu Z. Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation. Molecular Neurodegeneration. 6: 34. PMID 21595948 DOI: 10.1186/1750-1326-6-34  0.34
2011 Lee KW, Chen W, Junn E, Im JY, Grosso H, Sonsalla PK, Feng X, Ray N, Fernandez JR, Chao Y, Masliah E, Voronkov M, Braithwaite SP, Stock JB, Mouradian MM. Enhanced phosphatase activity attenuates α-synucleinopathy in a mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6963-71. PMID 21562258 DOI: 10.1523/Jneurosci.6513-10.2011  0.384
2011 Masliah E, Rockenstein E, Mante M, Crews L, Spencer B, Adame A, Patrick C, Trejo M, Ubhi K, Rohn TT, Mueller-Steiner S, Seubert P, Barbour R, McConlogue L, Buttini M, et al. Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease. Plos One. 6: e19338. PMID 21559417 DOI: 10.1371/Journal.Pone.0019338  0.641
2011 Nakamura K, Nemani VM, Azarbal F, Skibinski G, Levy JM, Egami K, Munishkina L, Zhang J, Gardner B, Wakabayashi J, Sesaki H, Cheng Y, Finkbeiner S, Nussbaum RL, Masliah E, et al. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein. The Journal of Biological Chemistry. 286: 20710-26. PMID 21489994 DOI: 10.1074/Jbc.M110.213538  0.326
2011 Lam HA, Wu N, Cely I, Kelly RL, Hean S, Richter F, Magen I, Cepeda C, Ackerson LC, Walwyn W, Masliah E, Chesselet MF, Levine MS, Maidment NT. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein. Journal of Neuroscience Research. 89: 1091-102. PMID 21488084 DOI: 10.1002/Jnr.22611  0.337
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Masliah E, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.519
2011 Haggerty T, Credle J, Rodriguez O, Wills J, Oaks AW, Masliah E, Sidhu A. Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease. The European Journal of Neuroscience. 33: 1598-610. PMID 21453448 DOI: 10.1111/J.1460-9568.2011.07660.X  0.398
2011 Patrick C, Crews L, Desplats P, Dumaop W, Rockenstein E, Achim CL, Everall IP, Masliah E. Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine. The American Journal of Pathology. 178: 1646-61. PMID 21435449 DOI: 10.1016/J.Ajpath.2010.12.033  0.646
2011 Ratai EM, Annamalai L, Burdo T, Joo CG, Bombardier JP, Fell R, Hakimelahi R, He J, Lentz MR, Campbell J, Curran E, Halpern EF, Masliah E, Westmoreland SV, Williams KC, et al. Brain creatine elevation and N-Acetylaspartate reduction indicates neuronal dysfunction in the setting of enhanced glial energy metabolism in a macaque model of neuroAIDS. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 66: 625-34. PMID 21381104 DOI: 10.1002/Mrm.22821  0.332
2011 Crews L, Patrick C, Adame A, Rockenstein E, Masliah E. Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease. Cell Death & Disease. 2: e120. PMID 21368891 DOI: 10.1038/Cddis.2011.2  0.689
2011 Zepa L, Frenkel M, Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM. ApoE4-Driven Accumulation of Intraneuronal Oligomerized Aβ42 following Activation of the Amyloid Cascade In Vivo Is Mediated by a Gain of Function. International Journal of Alzheimer's Disease. 2011: 792070. PMID 21350674 DOI: 10.4061/2011/792070  0.406
2011 Song W, Chen J, Petrilli A, Liot G, Klinglmayr E, Zhou Y, Poquiz P, Tjong J, Pouladi MA, Hayden MR, Masliah E, Ellisman M, Rouiller I, Schwarzenbacher R, Bossy B, et al. Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nature Medicine. 17: 377-82. PMID 21336284 DOI: 10.1038/Nm.2313  0.353
2011 Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, ... ... Masliah E, et al. In vivo demonstration that alpha-synuclein oligomers are toxic. Proceedings of the National Academy of Sciences of the United States of America. 108: 4194-9. PMID 21325059 DOI: 10.1073/Pnas.1100976108  0.381
2011 Spencer B, Marr RA, Gindi R, Potkar R, Michael S, Adame A, Rockenstein E, Verma IM, Masliah E. Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease. Plos One. 6: e16575. PMID 21304989 DOI: 10.1371/Journal.Pone.0016575  0.428
2011 Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E. Alpha-synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. The Journal of Biological Chemistry. 286: 9031-7. PMID 21296890 DOI: 10.1074/Jbc.C110.212589  0.346
2011 Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA. Neprilysin-2 is an important β-amyloid degrading enzyme. The American Journal of Pathology. 178: 306-12. PMID 21224067 DOI: 10.1016/J.Ajpath.2010.11.012  0.39
2011 Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski MH. Association of early experience with neurodegeneration in aged primates. Neurobiology of Aging. 32: 151-6. PMID 19321231 DOI: 10.1016/J.Neurobiolaging.2009.01.014  0.312
2011 Salmon DP, Masliah E, Galasko D, Peavy G, Hansen L, Hamilton J. P1-168: Behavioral abnormalities are associated with milder dementia in Alzheimer's disease than in dementia with lewy bodies Alzheimer's & Dementia. 7: S165-S166. DOI: 10.1016/J.Jalz.2011.05.447  0.337
2011 Gate D, Masliah E, Rezai-Zadeh K, Town T, Rentsendorj A. O1-03-05: IRAK-M deletion activates microglia and restricts cerebral amyloid in PSAPP mice Alzheimer's & Dementia. 7: S99-S99. DOI: 10.1016/J.Jalz.2011.05.243  0.312
2011 Gan L, Min S, Cho S, Zhou Y, Haroutunian V, Seeley B, Huang E, Shen Y, Masliah E, Cole P, Ott M. Acetylation of tau contributes to tau accumulation and dysfunction Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1989  0.332
2011 Fisher R, Gannon K, Krishnan R, Tsubery H, Masliah E, Rockenstein E, Kirschner D, Inouye H, Myszka D, Cirrito J, Green K, Wright J, Solomon J, LaFerla F, Solomon B. NPT001: A candidate therapeutic for clearance of beta-amyloid and tau aggregates in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1328  0.385
2011 Tank J, daCosta-Goncalves, Ubhi K, Rockenstein E, Diedrich A, Masliah E, Jordan J. Mice overexpressing human alpha synuclein in oligodendrocytes do not develop an autonomic failure phenotype Autonomic Neuroscience: Basic and Clinical. 163: 110. DOI: 10.1016/J.Autneu.2011.05.194  0.315
2010 Price DL, Rockenstein E, Ubhi K, Phung V, MacLean-Lewis N, Askay D, Cartier A, Spencer B, Patrick C, Desplats P, Ellisman MH, Masliah E. Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. Plos One. 5: e14020. PMID 21103359 DOI: 10.1371/Journal.Pone.0014020  0.375
2010 Kwak YD, Ma T, Diao S, Zhang X, Chen Y, Hsu J, Lipton SA, Masliah E, Xu H, Liao FF. NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration. Molecular Neurodegeneration. 5: 49. PMID 21067594 DOI: 10.1186/1750-1326-5-49  0.339
2010 Fujita M, Sugama S, Sekiyama K, Sekigawa A, Tsukui T, Nakai M, Waragai M, Takenouchi T, Takamatsu Y, Wei J, Rockenstein E, Laspada AR, Masliah E, Inoue S, Hashimoto M. A β-synuclein mutation linked to dementia produces neurodegeneration when expressed in mouse brain. Nature Communications. 1: 110. PMID 21045828 DOI: 10.1038/Ncomms1101  0.361
2010 Lee SJ, Desplats P, Sigurdson C, Tsigelny I, Masliah E. Cell-to-cell transmission of non-prion protein aggregates. Nature Reviews. Neurology. 6: 702-6. PMID 21045796 DOI: 10.1038/Nrneurol.2010.145  0.352
2010 Harris JA, Devidze N, Verret L, Ho K, Halabisky B, Thwin MT, Kim D, Hamto P, Lo I, Yu GQ, Palop JJ, Masliah E, Mucke L. Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network. Neuron. 68: 428-41. PMID 21040845 DOI: 10.1016/J.Neuron.2010.10.020  0.433
2010 Maarouf CL, Daugs ID, Kokjohn TA, Kalback WM, Patton RL, Luehrs DC, Masliah E, Nicoll JA, Sabbagh MN, Beach TG, Castaño EM, Roher AE. The biochemical aftermath of anti-amyloid immunotherapy. Molecular Neurodegeneration. 5: 39. PMID 20929585 DOI: 10.1186/1750-1326-5-39  0.402
2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron. 67: 953-66. PMID 20869593 DOI: 10.1016/J.Neuron.2010.08.044  0.372
2010 Belinson H, Kariv-Inbal Z, Kayed R, Masliah E, Michaelson DM. Following activation of the amyloid cascade, apolipoprotein E4 drives the in vivo oligomerization of amyloid-β resulting in neurodegeneration. Journal of Alzheimer's Disease : Jad. 22: 959-70. PMID 20858958 DOI: 10.3233/Jad-2010-101008  0.411
2010 Ubhi K, Peng K, Lessig S, Estrella J, Adame A, Galasko D, Salmon DP, Hansen LA, Kawas CH, Masliah E. Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease. Neuroscience Letters. 485: 222-7. PMID 20849919 DOI: 10.1016/J.Neulet.2010.09.016  0.337
2010 Crews L, Adame A, Patrick C, Delaney A, Pham E, Rockenstein E, Hansen L, Masliah E. Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12252-62. PMID 20844121 DOI: 10.1523/Jneurosci.1305-10.2010  0.693
2010 Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 107: 16970-5. PMID 20837543 DOI: 10.1073/Pnas.1011751107  0.331
2010 Miller J, Arrasate M, Shaby BA, Mitra S, Masliah E, Finkbeiner S. Quantitative relationships between huntingtin levels, polyglutamine length, inclusion body formation, and neuronal death provide novel insight into huntington's disease molecular pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10541-50. PMID 20685997 DOI: 10.1523/Jneurosci.0146-10.2010  0.342
2010 Lee SJ, Lee HJ, Masliah E. Multiple non-cell autonomous actions of alpha-synuclein in neurodegenerative diseases: Is there a direct link? Cell Cycle (Georgetown, Tex.). 9: 2696-7. PMID 20647760 DOI: 10.4161/Cc.9.14.12590  0.323
2010 Buttini M, Masliah E, Yu GQ, Palop JJ, Chang S, Bernardo A, Lin C, Wyss-Coray T, Huang Y, Mucke L. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. The American Journal of Pathology. 177: 563-9. PMID 20595630 DOI: 10.2353/Ajpath.2010.090973  0.399
2010 Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. The Febs Journal. 277: 3051-67. PMID 20573181 DOI: 10.1111/J.1742-4658.2010.07719.X  0.689
2010 Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. Regulation of amyloid precursor protein processing by the Beclin 1 complex. Plos One. 5: e11102. PMID 20559548 DOI: 10.1371/Journal.Pone.0011102  0.397
2010 Scott DA, Tabarean I, Tang Y, Cartier A, Masliah E, Roy S. A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8083-95. PMID 20554859 DOI: 10.1523/Jneurosci.1091-10.2010  0.695
2010 Lessig S, Ubhi K, Galasko D, Adame A, Pham E, Remidios K, Chang M, Hansen LA, Masliah E. Reduced hypocretin (orexin) levels in dementia with Lewy bodies. Neuroreport. 21: 756-60. PMID 20531237 DOI: 10.1097/Wnr.0B013E32833Bfb7C  0.33
2010 Unni VK, Weissman TA, Rockenstein E, Masliah E, McLean PJ, Hyman BT. In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. Plos One. 5: e10589. PMID 20485674 DOI: 10.1371/Journal.Pone.0010589  0.378
2010 Bossy B, Petrilli A, Klinglmayr E, Chen J, Lütz-Meindl U, Knott AB, Masliah E, Schwarzenbacher R, Bossy-Wetzel E. S-Nitrosylation of DRP1 does not affect enzymatic activity and is not specific to Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 20: S513-26. PMID 20463395 DOI: 10.3233/Jad-2010-100552  0.395
2010 Masliah E, Xie F, Dayan S, Rockenstein E, Mante M, Adame A, Patrick CM, Chan AF, Zheng B. Genetic deletion of Nogo/Rtn4 ameliorates behavioral and neuropathological outcomes in amyloid precursor protein transgenic mice. Neuroscience. 169: 488-94. PMID 20433905 DOI: 10.1016/J.Neuroscience.2010.04.045  0.449
2010 Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Human Molecular Genetics. 19: R12-20. PMID 20413653 DOI: 10.1093/Hmg/Ddq160  0.688
2010 Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a Journal of Neurology. 133: 1312-27. PMID 20360050 DOI: 10.1093/Brain/Awq056  0.38
2010 Alcantara-Gonzalez F, Juarez I, Solis O, Martinez-Tellez I, Camacho-Abrego I, Masliah E, Mena R, Flores G. Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration. Synapse (New York, N.Y.). 64: 786-93. PMID 20336627 DOI: 10.1002/Syn.20787  0.336
2010 Paleologou KE, Oueslati A, Shakked G, Rospigliosi CC, Kim HY, Lamberto GR, Fernandez CO, Schmid A, Chegini F, Gai WP, Chiappe D, Moniatte M, Schneider BL, Aebischer P, Eliezer D, ... ... Masliah E, et al. Phosphorylation at S87 is enhanced in synucleinopathies, inhibits alpha-synuclein oligomerization, and influences synuclein-membrane interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3184-98. PMID 20203178 DOI: 10.1523/Jneurosci.5922-09.2010  0.366
2010 Crews L, Spencer B, Desplats P, Patrick C, Paulino A, Rockenstein E, Hansen L, Adame A, Galasko D, Masliah E. Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy. Plos One. 5: e9313. PMID 20174468 DOI: 10.1371/Journal.Pone.0009313  0.683
2010 Crews L, Rockenstein E, Masliah E. APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis. Brain Structure & Function. 214: 111-26. PMID 20091183 DOI: 10.1007/S00429-009-0232-6  0.679
2010 Lee HJ, Suk JE, Patrick C, Bae EJ, Cho JH, Rho S, Hwang D, Masliah E, Lee SJ. Direct transfer of alpha-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies. The Journal of Biological Chemistry. 285: 9262-72. PMID 20071342 DOI: 10.1074/Jbc.M109.081125  0.354
2010 Harris JA, Devidze N, Halabisky B, Lo I, Thwin MT, Yu GQ, Bredesen DE, Masliah E, Mucke L. Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 372-81. PMID 20053918 DOI: 10.1523/Jneurosci.5341-09.2010  0.427
2010 Wu N, Joshi PR, Cepeda C, Masliah E, Levine MS. Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway. Journal of Neuroscience Research. 88: 1764-76. PMID 20029978 DOI: 10.1002/Jnr.22327  0.384
2010 Koob AO, Ubhi K, Paulsson JF, Kelly J, Rockenstein E, Mante M, Adame A, Masliah E. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Experimental Neurology. 221: 267-74. PMID 19944097 DOI: 10.1016/J.Expneurol.2009.11.015  0.727
2010 Koob AO, Paulino AD, Masliah E. GFAP reactivity, apolipoprotein E redistribution and cholesterol reduction in human astrocytes treated with alpha-synuclein. Neuroscience Letters. 469: 11-4. PMID 19932737 DOI: 10.1016/J.Neulet.2009.11.034  0.722
2010 Mbefo MK, Paleologou KE, Boucharaba A, Oueslati A, Schell H, Fournier M, Olschewski D, Yin G, Zweckstetter M, Masliah E, Kahle PJ, Hirling H, Lashuel HA. Phosphorylation of synucleins by members of the Polo-like kinase family. The Journal of Biological Chemistry. 285: 2807-22. PMID 19889641 DOI: 10.1074/Jbc.M109.081950  0.349
2010 Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Erratum to Acetylation of tau inhibits its degradation and contributes to tauopathy Neuron. 68. DOI: 10.1016/J.Neuron.2010.11.013  0.309
2010 Roy S, Scott D, Masliah E, Das U, Tang Y. O4-05-08: A pathologic cascade causing synaptic dysfunction in α-synuclein-induced neurodegeneration Alzheimer's & Dementia. 6: S158-S159. DOI: 10.1016/J.Jalz.2010.05.495  0.643
2010 Zwilling D, Truong J, Andrews-Zwilling Y, Hsieh E, Louie J, Huang Y, Muchowski JM, Masliah E, Schwarcz R, Muchowski PJ. An inhibitor of kynurenine 3-monooxygenase is neuroprotective in a mouse model of Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1975  0.36
2010 Nagahara AH, Mateling M, Eggert S, Blesch A, Rockenstein E, Koo EH, Masliah E, Tuszynski MH. P3-323: Early BDNF gene delivery into entorhinal cortex in APP transgenic mice ameliorates cells loss and preserves context-dependent fear conditioning Alzheimer's & Dementia. 6: S547-S547. DOI: 10.1016/J.Jalz.2010.05.1824  0.315
2010 Ubhi K, Peng KA, Lessig S, Estrella J, Adame A, Galasko D, Salmon DP, Hansen LA, Kawas CH, Masliah E. P2-117: Age, clinical indices and neuropathology in Alzheimer disease and dementia with lewy bodies Alzheimer's & Dementia. 6: S347-S348. DOI: 10.1016/J.Jalz.2010.05.1164  0.334
2009 Cohen E, Paulsson JF, Blinder P, Burstyn-Cohen T, Du D, Estepa G, Adame A, Pham HM, Holzenberger M, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 signaling delays age-associated proteotoxicity in mice. Cell. 139: 1157-69. PMID 20005808 DOI: 10.1016/J.Cell.2009.11.014  0.381
2009 Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13578-88. PMID 19864570 DOI: 10.1523/Jneurosci.4390-09.2009  0.387
2009 Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiology of Disease. 36: 293-302. PMID 19660551 DOI: 10.1016/J.Nbd.2009.07.021  0.386
2009 Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ. Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proceedings of the National Academy of Sciences of the United States of America. 106: 13010-5. PMID 19651612 DOI: 10.1073/Pnas.0903691106  0.658
2009 Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ. Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9104-14. PMID 19605647 DOI: 10.1523/Jneurosci.2250-09.2009  0.377
2009 Dziewczapolski G, Glogowski CM, Masliah E, Heinemann SF. Deletion of the alpha 7 nicotinic acetylcholine receptor gene improves cognitive deficits and synaptic pathology in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8805-15. PMID 19587288 DOI: 10.1523/Jneurosci.6159-08.2009  0.453
2009 Crews L, Tsigelny I, Hashimoto M, Masliah E. Role of synucleins in Alzheimer's disease. Neurotoxicity Research. 16: 306-17. PMID 19551456 DOI: 10.1007/S12640-009-9073-6  0.678
2009 Bengoechea TG, Chen Z, O'Leary DA, O'Leary D, Masliah E, Lee KF. p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model. Proceedings of the National Academy of Sciences of the United States of America. 106: 7870-5. PMID 19416837 DOI: 10.1073/Pnas.0901533106  0.424
2009 Crews L, Patrick C, Achim CL, Everall IP, Masliah E. Molecular pathology of neuro-AIDS (CNS-HIV). International Journal of Molecular Sciences. 10: 1045-63. PMID 19399237 DOI: 10.3390/Ijms10031045  0.619
2009 Shaked GM, Chauv S, Ubhi K, Hansen LA, Masliah E. Interactions between the amyloid precursor protein C-terminal domain and G proteins mediate calcium dysregulation and amyloid beta toxicity in Alzheimer's disease. The Febs Journal. 276: 2736-51. PMID 19368557 DOI: 10.1111/J.1742-4658.2009.06997.X  0.346
2009 Watson JB, Hatami A, David H, Masliah E, Roberts K, Evans CE, Levine MS. Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein. Neuroscience. 159: 501-13. PMID 19361478 DOI: 10.1016/J.Neuroscience.2009.01.021  0.372
2009 Wei J, Fujita M, Nakai M, Waragai M, Sekigawa A, Sugama S, Takenouchi T, Masliah E, Hashimoto M. Protective role of endogenous gangliosides for lysosomal pathology in a cellular model of synucleinopathies. The American Journal of Pathology. 174: 1891-909. PMID 19349362 DOI: 10.2353/Ajpath.2009.080680  0.374
2009 Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC, Francke U. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. The Journal of Comparative Neurology. 514: 240-58. PMID 19296534 DOI: 10.1002/Cne.22009  0.312
2009 Achim CL, Adame A, Dumaop W, Everall IP, Masliah E. Increased accumulation of intraneuronal amyloid beta in HIV-infected patients. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 190-9. PMID 19288297 DOI: 10.1007/S11481-009-9152-8  0.347
2009 Ubhi K, Rockenstein E, Doppler E, Mante M, Adame A, Patrick C, Trejo M, Crews L, Paulino A, Moessler H, Masliah E. Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin. Acta Neuropathologica. 117: 699-712. PMID 19252918 DOI: 10.1007/S00401-009-0505-4  0.677
2009 Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature Medicine. 15: 331-7. PMID 19198615 DOI: 10.1038/Nm.1912  0.425
2009 Chu J, Hong NA, Masuda CA, Jenkins BV, Nelms KA, Goodnow CC, Glynne RJ, Wu H, Masliah E, Joazeiro CA, Kay SA. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 106: 2097-103. PMID 19196968 DOI: 10.1073/Pnas.0812819106  0.356
2009 Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/Jneurosci.4220-08.2009  0.681
2009 Marongiu R, Spencer B, Crews L, Adame A, Patrick C, Trejo M, Dallapiccola B, Valente EM, Masliah E. Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux. Journal of Neurochemistry. 108: 1561-74. PMID 19166511 DOI: 10.1111/J.1471-4159.2009.05932.X  0.786
2009 Khanlou N, Moore DJ, Chana G, Cherner M, Lazzaretto D, Dawes S, Grant I, Masliah E, Everall IP. Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection. Journal of Neurovirology. 15: 131-8. PMID 19115126 DOI: 10.1080/13550280802578075  0.331
2009 Belichenko PV, Kleschevnikov AM, Masliah E, Wu C, Takimoto-Kimura R, Salehi A, Mobley WC. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. The Journal of Comparative Neurology. 512: 453-66. PMID 19034952 DOI: 10.1002/Cne.21895  0.326
2009 Rockenstein E, Doppler E, Moessler H, Li B, Blanchard J, Grundke-Iqbal I, Iqbal K, Mante M, Adame A, Masliah E. P4-030: Development of neuropeptides that promote neurogenesis in models of Alzheimer's and Parkinson's disease Alzheimer's & Dementia. 5: P440-P440. DOI: 10.1016/J.Jalz.2009.04.900  0.339
2009 Pham HM, Cartier A, Neild N, Hansen L, Adame A, Galasko D, Koo E, Glabe C, Masliah E. P4-233: Accumulation of Abeta oligomers in Alzheimer's disease is associated with cognitive impairment by disrupting scaffold dendritic spine proteins: Effects of immunotherapy Alzheimer's & Dementia. 5: P498-P499. DOI: 10.1016/J.Jalz.2009.04.699  0.376
2009 Nagahara AH, Schroeder BE, Coppola G, Wang L, Blesch A, Rockenstein E, Geschwind D, Masliah E, Koo EH, Tuszynski MH. P2-219: Restorative effects of BDNF gene delivery into entorhinal cortex in APP transgenic mice Alzheimer's & Dementia. 5: P324-P325. DOI: 10.1016/J.Jalz.2009.04.532  0.311
2009 Crews L, Spencer B, Masliah E. Role of Aβ degrading enzymes in synaptic plasticity and neurogenesis in Alzheimer's disease Current Hypotheses and Research Milestones in Alzheimer's Disease. 3-12. DOI: 10.1007/978-0-387-87995-6_1  0.613
2008 Spencer B, Marr RA, Rockenstein E, Crews L, Adame A, Potkar R, Patrick C, Gage FH, Verma IM, Masliah E. Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice. Bmc Neuroscience. 9: 109. PMID 19014502 DOI: 10.1186/1471-2202-9-109  0.665
2008 Norman JP, Perry SW, Reynolds HM, Kiebala M, De Mesy Bentley KL, Trejo M, Volsky DJ, Maggirwar SB, Dewhurst S, Masliah E, Gelbard HA. HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization. Plos One. 3: e3731. PMID 19009018 DOI: 10.1371/Journal.Pone.0003731  0.337
2008 Hamilton JM, Salmon DP, Galasko D, Raman R, Emond J, Hansen LA, Masliah E, Thal LJ. Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies. Neuropsychology. 22: 729-37. PMID 18999346 DOI: 10.1037/A0012949  0.343
2008 Crews L, Lentz MR, Gonzalez RG, Fox HS, Masliah E. Neuronal injury in simian immunodeficiency virus and other animal models of neuroAIDS. Journal of Neurovirology. 14: 327-39. PMID 18780234 DOI: 10.1080/13550280802132840  0.612
2008 Tsigelny IF, Crews L, Desplats P, Shaked GM, Sharikov Y, Mizuno H, Spencer B, Rockenstein E, Trejo M, Platoshyn O, Yuan JX, Masliah E. Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. Plos One. 3: e3135. PMID 18769546 DOI: 10.1371/Journal.Pone.0003135  0.675
2008 Fleming SM, Tetreault NA, Mulligan CK, Hutson CB, Masliah E, Chesselet MF. Olfactory deficits in mice overexpressing human wildtype alpha-synuclein. The European Journal of Neuroscience. 28: 247-56. PMID 18702696 DOI: 10.1111/J.1460-9568.2008.06346.X  0.336
2008 Tsigelny IF, Sharikov Y, Miller MA, Masliah E. Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies. Nanomedicine : Nanotechnology, Biology, and Medicine. 4: 350-7. PMID 18640077 DOI: 10.1016/J.Nano.2008.05.005  0.342
2008 Crews L, Rockenstein E, Masliah E. Biological transgenic mouse models of Alzheimer's disease. Handbook of Clinical Neurology. 89: 291-301. PMID 18631753 DOI: 10.1016/S0072-9752(07)01227-4  0.652
2008 Doppler E, Rockenstein E, Ubhi K, Inglis C, Mante M, Adame A, Crews L, Hitzl M, Moessler H, Masliah E. Neurotrophic effects of Cerebrolysin in the Mecp2(308/Y) transgenic model of Rett syndrome. Acta Neuropathologica. 116: 425-37. PMID 18600331 DOI: 10.1007/S00401-008-0407-X  0.642
2008 Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, Wyss-Coray T. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. The Journal of Clinical Investigation. 118: 2190-9. PMID 18497889 DOI: 10.1172/Jci33585  0.467
2008 Belinson H, Lev D, Masliah E, Michaelson DM. Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4690-701. PMID 18448646 DOI: 10.1523/Jneurosci.5633-07.2008  0.437
2008 Crews L, Mizuno H, Desplats P, Rockenstein E, Adame A, Patrick C, Winner B, Winkler J, Masliah E. Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4250-60. PMID 18417705 DOI: 10.1523/Jneurosci.0066-08.2008  0.65
2008 Habib SL, Michel D, Masliah E, Thomas B, Ko HS, Dawson TM, Abboud H, Clark RA, Imam SZ. Role of tuberin in neuronal degeneration. Neurochemical Research. 33: 1113-6. PMID 18320306 DOI: 10.1007/S11064-007-9558-8  0.394
2008 Bar-On P, Crews L, Koob AO, Mizuno H, Adame A, Spencer B, Masliah E. Statins reduce neuronal alpha-synuclein aggregation in in vitro models of Parkinson's disease. Journal of Neurochemistry. 105: 1656-67. PMID 18248604 DOI: 10.1111/J.1471-4159.2008.05254.X  0.791
2008 Kawahara K, Hashimoto M, Bar-On P, Ho GJ, Crews L, Mizuno H, Rockenstein E, Imam SZ, Masliah E. alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 283: 6979-87. PMID 18195004 DOI: 10.1074/Jbc.M710418200  0.658
2008 Mocchetti I, Bachis A, Masliah E. Chemokine receptors and neurotrophic factors: potential therapy against aids dementia? Journal of Neuroscience Research. 86: 243-55. PMID 17847079 DOI: 10.1002/Jnr.21492  0.324
2008 Winner B, Rockenstein E, Lie DC, Aigner R, Mante M, Bogdahn U, Couillard-Despres S, Masliah E, Winkler J. Mutant alpha-synuclein exacerbates age-related decrease of neurogenesis. Neurobiology of Aging. 29: 913-25. PMID 17275140 DOI: 10.1016/J.Neurobiolaging.2006.12.016  0.35
2008 Dziewczapolski G, Glogowski C, Masliah E, Heinemann SF. P1-070: Absence of α7 nicotinic acetylcholine receptors (α7nAChR) improve cognitive deficits and dendritic pathology in a mouse model of Alzheimer's disease (AD) Alzheimer's & Dementia. 4: T226-T227. DOI: 10.1016/J.Jalz.2008.05.656  0.36
2008 Novak P, Rockenstein E, Tatebayashi Y, Moessler H, Iqbal K, Masliah E. P2-450: Cerebrolysin stimulates neurogenesis in the dentate gyrus: A basis for neuronal replacement therapy in Alzheimer's disease? Alzheimer's & Dementia. 4: T505-T505. DOI: 10.1016/J.Jalz.2008.05.2496  0.343
2008 Pham HE, Hansen L, Adame A, Salmon D, Galasko D, Glabe C, Masliah E. P4-279: Progressive accumulation of Abeta oligomers in the brains of patients with Alzheimer's disease is associated with selective alterations in synaptic proteins Alzheimer's & Dementia. 4: T753-T753. DOI: 10.1016/J.Jalz.2008.05.2348  0.4
2008 Doppler EE, Rockenstein E, Moessler H, Mante M, Adame A, Crews L, Masliah E. P2-379: Neuroprotective effects of Cerebrolysin on neurofibrillary pathology in APP-transgenic mice that received neuronal gene transfer with AAV2-Tau Alzheimer's & Dementia. 4: T484-T484. DOI: 10.1016/J.Jalz.2008.05.1457  0.678
2007 Salaria S, Badkoobehi H, Rockenstein E, Crews L, Chana G, Masliah E, Everall IP. Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration. Journal of Neurovirology. 13: 496-503. PMID 18097881 DOI: 10.1080/13550280701558616  0.613
2007 Spencer B, Rockenstein E, Crews L, Marr R, Masliah E. Novel strategies for Alzheimer's disease treatment. Expert Opinion On Biological Therapy. 7: 1853-67. PMID 18034651 DOI: 10.1517/14712598.7.12.1853  0.667
2007 Alirezaei M, Watry DD, Flynn CF, Kiosses WB, Masliah E, Williams BR, Kaul M, Lipton SA, Fox HS. Human immunodeficiency virus-1/surface glycoprotein 120 induces apoptosis through RNA-activated protein kinase signaling in neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11047-55. PMID 17928446 DOI: 10.1523/Jneurosci.2733-07.2007  0.332
2007 Fernagut PO, Hutson CB, Fleming SM, Tetreaut NA, Salcedo J, Masliah E, Chesselet MF. Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression. Synapse (New York, N.Y.). 61: 991-1001. PMID 17879265 DOI: 10.1002/Syn.20456  0.404
2007 Rockenstein E, Crews L, Masliah E. Transgenic animal models of neurodegenerative diseases and their application to treatment development Advanced Drug Delivery Reviews. 59: 1093-1102. PMID 17869376 DOI: 10.1016/J.Addr.2007.08.013  0.683
2007 Waragai M, Nakai M, Wei J, Fujita M, Mizuno H, Ho G, Masliah E, Akatsu H, Yokochi F, Hashimoto M. Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's disease. Neuroscience Letters. 425: 18-22. PMID 17720313 DOI: 10.1016/J.Neulet.2007.08.010  0.312
2007 Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, ... Masliah E, et al. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathologica. 114: 221-9. PMID 17653732 DOI: 10.1007/S00401-007-0261-2  0.401
2007 Wei J, Fujita M, Nakai M, Waragai M, Watabe K, Akatsu H, Rockenstein E, Masliah E, Hashimoto M. Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies. The Journal of Biological Chemistry. 282: 28904-14. PMID 17652097 DOI: 10.1074/Jbc.M703711200  0.332
2007 Kuczenski R, Everall IP, Crews L, Adame A, Grant I, Masliah E. Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat Experimental Neurology. 207: 42-51. PMID 17603040 DOI: 10.1016/J.Expneurol.2007.05.023  0.612
2007 Letendre S, Paulino AD, Rockenstein E, Adame A, Crews L, Cherner M, Heaton R, Ellis R, Everall IP, Grant I, Masliah E. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. The Journal of Infectious Diseases. 196: 361-70. PMID 17597450 DOI: 10.1086/519285  0.59
2007 Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT. Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. The American Journal of Pathology. 170: 1725-38. PMID 17456777 DOI: 10.2353/Ajpath.2007.061232  0.343
2007 Tsigelny IF, Bar-On P, Sharikov Y, Crews L, Hashimoto M, Miller MA, Keller SH, Platoshyn O, Yuan JXJ, Masliah E. Dynamics of α-synuclein aggregation and inhibition of pore-like oligomer development by β-synuclein Febs Journal. 274: 1862-1877. PMID 17381514 DOI: 10.1111/J.1742-4658.2007.05733.X  0.63
2007 Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, ... ... Masliah E, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68: 812-9. PMID 17353469 DOI: 10.1212/01.Wnl.0000256715.13907.D3  0.35
2007 Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E. Neuroprotective effects of regulators of the glycogen synthase kinase-3β signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation Journal of Neuroscience. 27: 1981-1991. PMID 17314294 DOI: 10.1523/Jneurosci.4321-06.2007  0.687
2007 Spencer B, Crews L, Masliah E. Climbing the scaffolds of Parkinson's disease pathogenesis. Neuron. 53: 469-70. PMID 17296545 DOI: 10.1016/J.Neuron.2007.02.002  0.659
2007 Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. Effects of Cerebrolysin™ on neurogenesis in an APP transgenic model of Alzheimer's disease Acta Neuropathologica. 113: 265-275. PMID 17131129 DOI: 10.1007/S00401-006-0166-5  0.687
2007 Zhou X, Qyang Y, Kelsoe JR, Masliah E, Geyer MA. Impaired postnatal development of hippocampal dentate gyrus in Sp4 null mutant mice. Genes, Brain, and Behavior. 6: 269-76. PMID 16899055 DOI: 10.1111/J.1601-183X.2006.00256.X  0.306
2006 Luo J, Lin AH, Masliah E, Wyss-Coray T. Bioluminescence imaging of Smad signaling in living mice shows correlation with excitotoxic neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 103: 18326-31. PMID 17110447 DOI: 10.1073/Pnas.0605077103  0.36
2006 Fujita M, Wei J, Nakai M, Masliah E, Hashimoto M. Chaperone and anti-chaperone: two-faced synuclein as stimulator of synaptic evolution. Neuropathology. 26: 383-392. PMID 17080714 DOI: 10.1111/J.1440-1789.2006.00732.X  0.368
2006 Tesseur I, Zou K, Esposito L, Bard F, Berber E, Can JV, Lin AH, Crews L, Tremblay P, Mathews P, Mucke L, Masliah E, Wyss-Coray T. Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology. The Journal of Clinical Investigation. 116: 3060-9. PMID 17080199 DOI: 10.1172/Jci27341  0.665
2006 Chana G, Everall IP, Crews L, Langford D, Adame A, Grant I, Cherner M, Lazzaretto D, Heaton R, Ellis R, Masliah E. Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users. Neurology. 67: 1486-9. PMID 17060582 DOI: 10.1212/01.Wnl.0000240066.02404.E6  0.595
2006 Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (New York, N.Y.). 314: 130-3. PMID 17023659 DOI: 10.1126/Science.1134108  0.346
2006 Mandal PK, Pettegrew JW, Masliah E, Hamilton RL, Mandal R. Interaction between Abeta peptide and alpha synuclein: molecular mechanisms in overlapping pathology of Alzheimer's and Parkinson's in dementia with Lewy body disease. Neurochemical Research. 31: 1153-62. PMID 16947080 DOI: 10.1007/S11064-006-9140-9  0.387
2006 Patton RL, Kalback WM, Esh CL, Kokjohn TA, Van Vickle GD, Luehrs DC, Kuo YM, Lopez J, Brune D, Ferrer I, Masliah E, Newel AJ, Beach TG, Castaño EM, Roher AE. Amyloid-beta peptide remnants in AN-1792-immunized Alzheimer's disease patients: a biochemical analysis. The American Journal of Pathology. 169: 1048-63. PMID 16936277 DOI: 10.2353/Ajpath.2006.060269  0.365
2006 Fleming SM, Salcedo J, Hutson CB, Rockenstein E, Masliah E, Levine MS, Chesselet MF. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein. Neuroscience. 142: 1245-53. PMID 16934409 DOI: 10.1016/J.Neuroscience.2006.07.005  0.359
2006 Masliah E, Crews L, Hansen L. Synaptic remodeling during aging and in Alzheimer's disease Journal of Alzheimer's Disease. 9: 91-99. PMID 16914848 DOI: 10.3233/Jad-2006-9S311  0.625
2006 Bar-On P, Rockenstein E, Adame A, Ho G, Hashimoto M, Masliah E. Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathy. Journal of Neurochemistry. 98: 1032-45. PMID 16895578 DOI: 10.1111/J.1471-4159.2006.04017.X  0.349
2006 Trifilo MJ, Yajima T, Gu Y, Dalton N, Peterson KL, Race RE, Meade-White K, Portis JL, Masliah E, Knowlton KU, Chesebro B, Oldstone MB. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (New York, N.Y.). 313: 94-7. PMID 16825571 DOI: 10.1126/Science.1128635  0.341
2006 Uehara T, Nakamura T, Yao D, Shi ZQ, Gu Z, Ma Y, Masliah E, Nomura Y, Lipton SA. S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration. Nature. 441: 513-7. PMID 16724068 DOI: 10.1038/Nature04782  0.328
2006 Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L. Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 5167-79. PMID 16687508 DOI: 10.1523/Jneurosci.0482-06.2006  0.452
2006 Moore DJ, Masliah E, Rippeth JD, Gonzalez R, Carey CL, Cherner M, Ellis RJ, Achim CL, Marcotte TD, Heaton RK, Grant I. Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. Aids (London, England). 20: 879-87. PMID 16549972 DOI: 10.1097/01.Aids.0000218552.69834.00  0.308
2006 Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E. Cerebrolysin decreases amyloid-β production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease Journal of Neuroscience Research. 83: 1252-1261. PMID 16511867 DOI: 10.1002/Jnr.20818  0.683
2006 Webster B, Hansen L, Adame A, Crews L, Torrance M, Thal L, Masliah E. Astroglial activation of extracellular-regulated kinase in early stages of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 65: 142-51. PMID 16462205 DOI: 10.1097/01.Jnen.0000199599.63204.6F  0.66
2006 Singer O, Marr RA, Rockenstein E, Crow L, Gage FH, Verma IM, Masliah E. 81. Hippocampal Gene Knockdown of BACE1 by Lentiviral Gene Transfer of siRNA Reduces Amyloid Pathology and Improves Memory Performance in APP Transgenic Mice Molecular Therapy. 13: S34. DOI: 10.1016/J.Ymthe.2006.08.099  0.419
2006 Price DL, Rockenstein E, MacLean NAB, Phung V, Masliah E, Ellisman MH. P1-024: Altered dopamine receptor immunoreactivity in CNS of transgenic mice overexpressing alpha-synuclein Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.399  0.33
2006 Pickford F, Masliah E, Small S, Rockenstein E, Levine B, Wyss-Coray T. O4-05-02: Deficiency of the Beclin 1 autophagy protein promotes Alzheimer's disease pathology Alzheimer's & Dementia. 2: S85-S85. DOI: 10.1016/J.Jalz.2006.05.328  0.456
2006 Rockenstein E, Mante M, Adame A, Crews L, Moessler H, Masliah E. P4-374: Effects of cerebrolysin on neurogenesis in an amyloid precursor protein transgenic animal model of Alzheimer's disease Alzheimer's & Dementia. 2: S628-S628. DOI: 10.1016/J.Jalz.2006.05.2115  0.67
2006 Esposito L, Yan F, Yu G, Wang X, Puolivali J, Scearce-Levie K, Masliah E, Mucke L. P3-359: Reduction of mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology in human amyloid precursor protein transgenic mice Alzheimer's & Dementia. 2: S480-S480. DOI: 10.1016/J.Jalz.2006.05.1629  0.412
2005 Shults CW, Rockenstein E, Crews L, Adame A, Mante M, Larrea G, Hashimoto M, Song D, Iwatsubo T, Tsuboi K, Masliah E. Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10689-99. PMID 16291942 DOI: 10.1523/Jneurosci.3527-05.2005  0.647
2005 Gilman S, May SJ, Shults CW, Tanner CM, Kukull W, Lee VM, Masliah E, Low P, Sandroni P, Trojanowski JQ, Ozelius L, Foroud T. The North American Multiple System Atrophy Study Group. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1687-94. PMID 16284910 DOI: 10.1007/S00702-005-0381-6  0.315
2005 Bellizzi MJ, Lu SM, Masliah E, Gelbard HA. Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor. The Journal of Clinical Investigation. 115: 3185-92. PMID 16276420 DOI: 10.1172/Jci25444  0.308
2005 Everall IP, Hansen LA, Masliah E. The shifting patterns of HIV encephalitis neuropathology. Neurotoxicity Research. 8: 51-61. PMID 16260385 DOI: 10.1007/Bf03033819  0.311
2005 Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L. Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9694-703. PMID 16237174 DOI: 10.1523/Jneurosci.2980-05.2005  0.426
2005 Singer O, Marr RA, Rockenstein E, Crews L, Coufal NG, Gage FH, Verma IM, Masliah E. Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nature Neuroscience. 8: 1343-9. PMID 16136043 DOI: 10.1038/Nn1531  0.681
2005 Wu CK, Thal L, Pizzo D, Hansen L, Masliah E, Geula C. Apoptotic signals within the basal forebrain cholinergic neurons in Alzheimer's disease Experimental Neurology. 195: 484-496. PMID 16085017 DOI: 10.1016/J.Expneurol.2005.06.020  0.386
2005 Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E. High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease. The Journal of Biological Chemistry. 280: 32957-67. PMID 16027115 DOI: 10.1074/Jbc.M507016200  0.678
2005 Chevallier NL, Soriano S, Kang DE, Masliah E, Hu G, Koo EH. Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. The American Journal of Pathology. 167: 151-9. PMID 15972961 DOI: 10.1016/S0002-9440(10)62962-8  0.306
2005 Masliah E, Rockenstein E, Adame A, Alford M, Crews L, Hashimoto M, Seubert P, Lee M, Goldstein J, Chilcote T, Games D, Schenk D. Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease. Neuron. 46: 857-68. PMID 15953415 DOI: 10.1016/J.Neuron.2005.05.010  0.669
2005 Chesebro B, Trifilo M, Race R, Meade-White K, Teng C, LaCasse R, Raymond L, Favara C, Baron G, Priola S, Caughey B, Masliah E, Oldstone M. Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science (New York, N.Y.). 308: 1435-9. PMID 15933194 DOI: 10.1126/Science.1110837  0.416
2005 Tsuboi K, Grzesiak JJ, Bouvet M, Hashimoto M, Masliah E, Shults CW. Alpha-synuclein overexpression in oligodendrocytic cells results in impaired adhesion to fibronectin and cell death Molecular and Cellular Neuroscience. 29: 259-268. PMID 15911350 DOI: 10.1016/J.Mcn.2005.03.001  0.308
2005 Lentz MR, Kim JP, Westmoreland SV, Greco JB, Fuller RA, Ratai EM, He J, Sehgal PK, Halpern EF, Lackner AA, Masliah E, González RG. Quantitative neuropathologic correlates of changes in ratio of N-acetylaspartate to creatine in macaque brain. Radiology. 235: 461-8. PMID 15798152 DOI: 10.1148/Radiol.2352040003  0.303
2005 Rockenstein E, Schwach G, Ingolic E, Adame A, Crews L, Mante M, Pfragner R, Schreiner E, Windisch M, Masliah E. Lysosomal pathology associated with α-synuclein accumulation in transgenic models using an eGFP fusion protein Journal of Neuroscience Research. 80: 247-259. PMID 15765523 DOI: 10.1002/Jnr.20446  0.676
2005 Green DA, Masliah E, Vinters HV, Beizai P, Moore DJ, Achim CL. Brain deposition of beta-amyloid is a common pathologic feature in HIV positive patients. Aids (London, England). 19: 407-11. PMID 15750394 DOI: 10.1097/01.Aids.0000161770.06158.5C  0.371
2005 Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science (New York, N.Y.). 307: 1282-8. PMID 15731448 DOI: 10.1126/Science.1105681  0.359
2005 Ho GJ, Hashimoto M, Adame A, Izu M, Alford MF, Thal LJ, Hansen LA, Masliah E. Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role. Neurobiology of Aging. 26: 625-35. PMID 15708437 DOI: 10.1016/J.Neurobiolaging.2004.06.016  0.426
2005 Rockenstein E, Adame A, Mante M, Larrea G, Crews L, Windisch M, Moessler H, Masliah E. Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound Cerebrolysin™ Journal of Neural Transmission. 112: 269-282. PMID 15657642 DOI: 10.1007/S00702-004-0181-4  0.69
2005 Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology. 64: 129-31. PMID 15642916 DOI: 10.1212/01.Wnl.0000148590.39911.Df  0.655
2005 Singer O, Marr RA, Rockenstein E, Crews L, Gage FH, Verma IM, Masliah E. 56. Amelioration of Neurodegenerative and Neuropathological Alterations in a Transgenic Model of Alzheimer's Disease: Targeting BACE1 with Small Interfering RNAs Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.084  0.684
2005 Masliah E, Roberts E, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox H. Corrigendum to “Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis” Journal of Neuroimmunology. 162: 197. DOI: 10.1016/J.Jneuroim.2005.01.013  0.579
2004 Langford D, Grigorian A, Hurford R, Adame A, Crews L, Masliah E. The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons Journal of Neurovirology. 10: 327-337. PMID 15765804 DOI: 10.1080/13550280490520961  0.629
2004 Hashimoto M, Kawahara K, Bar-On P, Rockenstein E, Crews L, Masliah E. The role of α-synuclein assembly and metabolism in the pathogenesis of Lewy body disease Journal of Molecular Neuroscience. 24: 343-352. PMID 15655259 DOI: 10.1385/Jmn:24:3:343  0.642
2004 Masliah E, Roberts ES, Langford D, Everall I, Crews L, Adame A, Rockenstein E, Fox HS. Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis Journal of Neuroimmunology. 157: 163-175. PMID 15579294 DOI: 10.1016/J.Jneuroim.2004.08.026  0.629
2004 Achim CL, Masliah E, Schindelar J, Avramut M. Immunophilin expression in the HIV-infected brain. Journal of Neuroimmunology. 157: 126-32. PMID 15579289 DOI: 10.1016/J.Jneuroim.2004.08.041  0.308
2004 Belichenko PV, Masliah E, Kleschevnikov AM, Villar AJ, Epstein CJ, Salehi A, Mobley WC. Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. The Journal of Comparative Neurology. 480: 281-98. PMID 15515178 DOI: 10.1002/Cne.20337  0.309
2004 Fleming SM, Salcedo J, Fernagut PO, Rockenstein E, Masliah E, Levine MS, Chesselet MF. Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9434-40. PMID 15496679 DOI: 10.1523/Jneurosci.3080-04.2004  0.349
2004 Hashimoto M, Rockenstein E, Mante M, Crews L, Bar-On P, Gage FH, Marr R, Masliah E. An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Therapy. 11: 1713-23. PMID 15483670 DOI: 10.1038/Sj.Gt.3302349  0.648
2004 Crews L, Wyss-Coray T, Masliah E. Insights into the pathogenesis of hydrocephalus from transgenic and experimental animal models. Brain Pathology (Zurich, Switzerland). 14: 312-6. PMID 15446587 DOI: 10.1111/J.1750-3639.2004.Tb00070.X  0.634
2004 Hamilton JM, Salmon DP, Galasko D, Delis DC, Hansen LA, Masliah E, Thomas RG, Thal LJ. A comparison of episodic memory deficits in neuropathologically-confirmed Dementia with Lewy bodies and Alzheimer's disease. Journal of the International Neuropsychological Society : Jins. 10: 689-97. PMID 15327716 DOI: 10.1017/S1355617704105043  0.323
2004 Yao D, Gu Z, Nakamura T, Shi ZQ, Ma Y, Gaston B, Palmer LA, Rockenstein EM, Zhang Z, Masliah E, Uehara T, Lipton SA. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 10810-4. PMID 15252205 DOI: 10.1073/Pnas.0404161101  0.359
2004 Licastro F, Chiappelli M, Thal LJ, Masliah E. alpha-1-Antichymotrypsin polymorphism in the gene promoter region affects survival and synapsis loss in Alzheimer's disease. Archives of Gerontology and Geriatrics. Supplement. 243-51. PMID 15207421 DOI: 10.1016/J.Archger.2004.04.034  0.364
2004 Tiraboschi P, Hansen LA, Masliah E, Alford M, Thal LJ, Corey-Bloom J. Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology. 62: 1977-83. PMID 15184600 DOI: 10.1212/01.Wnl.0000128091.92139.0F  0.353
2004 Chin J, Palop JJ, Yu GQ, Kojima N, Masliah E, Mucke L. Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4692-7. PMID 15140940 DOI: 10.1523/Jneurosci.0277-04.2004  0.434
2004 Tiraboschi P, Sabbagh MN, Hansen LA, Salmon DP, Merdes A, Gamst A, Masliah E, Alford M, Thal LJ, Corey-Bloom J. Alzheimer disease without neocortical neurofibrillary tangles: "a second look". Neurology. 62: 1141-7. PMID 15079014 DOI: 10.1212/01.Wnl.0000118212.41542.E7  0.406
2004 Kennedy BP, Bottiglieri T, Arning E, Ziegler MG, Hansen LA, Masliah E. Elevated S-adenosylhomocysteine in Alzheimer brain: influence on methyltransferases and cognitive function. Journal of Neural Transmission (Vienna, Austria : 1996). 111: 547-67. PMID 15057524 DOI: 10.1007/S00702-003-0096-5  0.324
2004 Klucken J, Shin Y, Masliah E, Hyman BT, McLean PJ. Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity. The Journal of Biological Chemistry. 279: 25497-502. PMID 15044495 DOI: 10.1074/Jbc.M400255200  0.336
2004 Hashimoto M, Bar-On P, Ho G, Takenouchi T, Rockenstein E, Crews L, Masliah E. β-synuclein regulates Akt activity in neuronal cells: A possible mechanism for neuroprotection in Parkinson's disease Journal of Biological Chemistry. 279: 23622-23629. PMID 15026413 DOI: 10.1074/Jbc.M313784200  0.65
2004 Song DD, Shults CW, Sisk A, Rockenstein E, Masliah E. Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP Experimental Neurology. 186: 158-172. PMID 15026254 DOI: 10.1016/S0014-4886(03)00342-X  0.357
2004 Solforosi L, Criado JR, McGavern DB, Wirz S, Sánchez-Alavez M, Sugama S, DeGiorgio LA, Volpe BT, Wiseman E, Abalos G, Masliah E, Gilden D, Oldstone MB, Conti B, Williamson RA. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo. Science (New York, N.Y.). 303: 1514-6. PMID 14752167 DOI: 10.1126/Science.1094273  0.349
2004 Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. Journal of Molecular Neuroscience : Mn. 22: 5-11. PMID 14742905 DOI: 10.1385/Jmn:22:1-2:5  0.377
2004 Hashimoto M, Masliah E. Cycles of aberrant synaptic sprouting and neurodegeneration in Alzheimer's and dementia with Lewy bodies. Neurochemical Research. 28: 1743-56. PMID 14584828 DOI: 10.1023/A:1026073324672  0.412
2004 Ioffe Y, Wong K, Masliah E, Miller B, Ray J, Gage FH, Miller AL. 85 THE ROLE OF AMYLOID IN THE CELLULAR PATHOLOGY OF ALZHEIMER'S DISEASE. Journal of Investigative Medicine. 52: S93.4-S93. DOI: 10.1136/Jim-52-Suppl1-85  0.4
2004 Rockenstein E, Mante M, Adame A, Crews L, Laurrea G, Masliah E. P1-296 Neuroprotective effects of compounds regulating the GSK3β pathway in a THY1-amyloid precursor protein transgenic animal model of Alzheimer's disease Neurobiology of Aging. 25: S180. DOI: 10.1016/S0197-4580(04)80609-2  0.663
2004 Tesseur IC, Zou K, Masliah E, Corn J, Brionne T, Bard F, Wyss-Coray T. P1-203 Inhibition of the TGF-beta signaling pathway results in increased neurodegeneration and amyloid deposition in human APP transgenic mice Neurobiology of Aging. 25: S154. DOI: 10.1016/S0197-4580(04)80516-5  0.345
2004 Chin J, Palop JJ, Puoliväli J, Massaro C, Yu G, Masliah E, Mucke L. O1-04-07 Overexpression of FYN kinase exacerbates cellular and behavioral deficits in human amyloid precursor protein transgenic mice Neurobiology of Aging. 25: S18. DOI: 10.1016/S0197-4580(04)80058-7  0.343
2004 Marr RA, Rockenstien E, Kindy MS, Hersh LB, Gage FH, Masliah E, Verma IM. 525. Therapy for Alzheimer's disease by neprilysin gene transfer Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.470  0.397
2003 Brionne TC, Tesseur I, Masliah E, Wyss-Coray T. Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron. 40: 1133-45. PMID 14687548 DOI: 10.1016/S0896-6273(03)00766-9  0.326
2003 Lu DC, Shaked GM, Masliah E, Bredesen DE, Koo EH. Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Annals of Neurology. 54: 781-9. PMID 14681887 DOI: 10.1002/Ana.10761  0.381
2003 Hashimoto M, Rockenstein E, Crews L, Masliah E. Role of Protein Aggregation in Mitochondrial Dysfunction and Neurodegeneration in Alzheimer's and Parkinson's Diseases Neuromolecular Medicine. 4: 21-35. PMID 14528050 DOI: 10.1385/Nmm:4:1-2:21  0.682
2003 Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y. Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 100: 10966-71. PMID 12939405 DOI: 10.1073/Pnas.1434398100  0.457
2003 Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proceedings of the National Academy of Sciences of the United States of America. 100: 9572-7. PMID 12881482 DOI: 10.1073/Pnas.1133381100  0.442
2003 Masliah E, Alford M, Adame A, Rockenstein E, Galasko D, Salmon D, Hansen LA, Thal LJ. Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD. Neurology. 61: 206-11. PMID 12874400 DOI: 10.1212/01.Wnl.0000073987.79060.4B  0.374
2003 Kennedy BP, Ziegler MG, Alford M, Hansen LA, Thal LJ, Masliah E. Early and persistent alterations in prefrontal cortex MAO A and B in Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 110: 789-801. PMID 12811639 DOI: 10.1007/S00702-003-0828-6  0.364
2003 Hashimoto M, Takenouchi T, Rockenstein E, Masliah E. Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease. Journal of Neurochemistry. 85: 1468-79. PMID 12787066 DOI: 10.1046/J.1471-4159.2003.01791.X  0.334
2003 Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1992-6. PMID 12657655 DOI: 10.1523/Jneurosci.23-06-01992.2003  0.416
2003 Everall IP, Bell C, Mallory M, Langford D, Adame A, Rockestein E, Masliah E. Lithium ameliorates HIV-gp120-mediated neurotoxicity. Molecular and Cellular Neurosciences. 21: 493-501. PMID 12498789 DOI: 10.1006/Mcne.2002.1196  0.335
2003 Windisch M, Hutter-Paier B, Rockenstein E, Hashimoto M, Mallory M, Masliah E. Development of a new treatment for Alzheimer's disease and Parkinson's disease using anti-aggregatory beta-synuclein-derived peptides. Journal of Molecular Neuroscience : Mn. 19: 63-9. PMID 12212795 DOI: 10.1007/S12031-002-0012-8  0.41
2002 Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10539-48. PMID 12486146 DOI: 10.1523/Jneurosci.22-24-10539.2002  0.429
2002 Masliah E, Hashimoto M. Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein. Neurotoxicology. 23: 461-8. PMID 12428718 DOI: 10.1016/S0161-813X(02)00029-3  0.398
2002 Van Uden E, Mallory M, Veinbergs I, Alford M, Rockenstein E, Masliah E. Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9298-304. PMID 12417655 DOI: 10.1523/Jneurosci.22-21-09298.2002  0.787
2002 Ho GJ, Hansen LA, Alford MF, Foster K, Salmon DP, Galasko D, Thal LJ, Masliah E. Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease. Neuroreport. 13: 1825-8. PMID 12395133 DOI: 10.1097/00001756-200210070-00028  0.37
2002 Tiraboschi P, Hansen LA, Alford M, Merdes A, Masliah E, Thal LJ, Corey-Bloom J. Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease. Archives of General Psychiatry. 59: 946-51. PMID 12365882 DOI: 10.1001/Archpsyc.59.10.946  0.359
2002 Wyss-Coray T, Yan F, Lin AH, Lambris JD, Alexander JJ, Quigg RJ, Masliah E. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 10837-42. PMID 12119423 DOI: 10.1073/Pnas.162350199  0.45
2002 Rockenstein E, Mallory M, Hashimoto M, Song D, Shults CW, Lang I, Masliah E. Differential neuropathological alterations in transgenic mice expressing α-synuclein from the platelet-derived growth factor and Thy-1 promoters Journal of Neuroscience Research. 68: 568-578. PMID 12111846 DOI: 10.1002/Jnr.10231  0.373
2002 Hashimoto M, Sagara Y, Langford D, Everall IP, Mallory M, Everson A, Digicaylioglu M, Masliah E. Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotection. The Journal of Biological Chemistry. 277: 32985-91. PMID 12095987 DOI: 10.1074/Jbc.M202803200  0.306
2002 Garden GA, Budd SL, Tsai E, Hanson L, Kaul M, D'Emilia DM, Friedlander RM, Yuan J, Masliah E, Lipton SA. Caspase cascades in human immunodeficiency virus-associated neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4015-24. PMID 12019321 DOI: 10.1523/Jneurosci.22-10-04015.2002  0.328
2002 Woulfe JM, Duke R, Middeldorp JM, Stevens S, Vervoort M, Hashimoto M, Masliah E, Chan P, Di Monte DA, Langston JW, Petzinger G, Hoogendoorn H, Munoz DG. Absence of elevated anti-alpha-synuclein and anti-EBV latent membrane protein antibodies in PD. Neurology. 58: 1435-6. PMID 12011302 DOI: 10.1212/Wnl.58.9.1435  0.321
2002 Veinbergs I, Everson A, Sagara Y, Masliah E. Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. Journal of Neuroscience Research. 67: 379-87. PMID 11813243 DOI: 10.1002/Jnr.10138  0.703
2002 Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T. alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nature Cell Biology. 4: 160-4. PMID 11813001 DOI: 10.1038/Ncb748  0.358
2002 Hashimoto M, Hsu LJ, Rockenstein E, Takenouchi T, Mallory M, Masliah E. alpha-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. The Journal of Biological Chemistry. 277: 11465-72. PMID 11790792 DOI: 10.1074/Jbc.M111428200  0.344
2002 Masliah E, Hansen LA, Rockenstein E, Hashimoto M. Progress in the development of new treatments for combined Alzheimer's and Parkinson's diseases Drug Development Research. 56: 282-292. DOI: 10.1002/Ddr.10082  0.364
2001 Xia Y, Saitoh T, Uéda K, Tanaka S, Chen X, Hashimoto M, Hsu L, Conrad C, Sundsmo M, Yoshimoto M, Thal L, Katzman R, Masliah E. Characterization of the human alpha-synuclein gene: Genomic structure, transcription start site, promoter region and polymorphisms. Journal of Alzheimer's Disease : Jad. 3: 485-494. PMID 12214035 DOI: 10.3233/Jad-2001-3508  0.3
2001 Masliah E, Alford M, Galasko D, Salmon D, Hansen LA, Good PF, Perl DP, Thal L. Cholinergic deficits in the brains of patients with parkinsonism-dementia complex of Guam. Neuroreport. 12: 3901-3. PMID 11742207 DOI: 10.1097/00001756-200112210-00009  0.346
2001 Chen Q, Yoshida H, Schubert D, Maher P, Mallory M, Masliah E. Presenilin binding protein is associated with neurofibrillary alterations in Alzheimer's disease and stimulates tau phosphorylation. The American Journal of Pathology. 159: 1597-602. PMID 11696419 DOI: 10.1016/S0002-9440(10)63005-2  0.396
2001 Masliah E, Ho G, Wyss-Coray T. Functional role of TGF beta in Alzheimer's disease microvascular injury: lessons from transgenic mice. Neurochemistry International. 39: 393-400. PMID 11578774 DOI: 10.1016/S0197-0186(01)00046-8  0.36
2001 Rockenstein E, Hansen LA, Mallory M, Trojanowski JQ, Galasko D, Masliah E. Altered expression of the synuclein family mRNA in Lewy body and Alzheimer's disease. Brain Research. 914: 48-56. PMID 11578596 DOI: 10.1016/S0006-8993(01)02772-X  0.408
2001 Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L. beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 98: 12245-50. PMID 11572944 DOI: 10.1073/Pnas.211412398  0.762
2001 Veinbergs I, Van Uden E, Mallory M, Alford M, McGiffert C, DeTeresa R, Orlando R, Masliah E. Role of apolipoprotein E receptors in regulating the differential in vivo neurotrophic effects of apolipoprotein E. Experimental Neurology. 170: 15-26. PMID 11421580 DOI: 10.1006/Exnr.2001.7684  0.729
2001 Wyss-Coray T, Lin C, Yan F, Yu GQ, Rohde M, McConlogue L, Masliah E, Mucke L. TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice. Nature Medicine. 7: 612-8. PMID 11329064 DOI: 10.1038/87945  0.356
2001 Masliah E, Sisk A, Mallory M, Games D. Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Journal of Neuropathology and Experimental Neurology. 60: 357-68. PMID 11305871 DOI: 10.1093/Jnen/60.4.357  0.425
2001 Zhukareva V, Vogelsberg-Ragaglia V, Van Deerlin VM, Bruce J, Shuck T, Grossman M, Clark CM, Arnold SE, Masliah E, Galasko D, Trojanowski JQ, Lee VM. Loss of brain tau defines novel sporadic and familial tauopathies with frontotemporal dementia. Annals of Neurology. 49: 165-75. PMID 11220736 DOI: 10.1002/1531-8249(20010201)49:2<165::Aid-Ana36>3.0.Co;2-3  0.379
2001 Yeon SW, Jung MW, Ha MJ, Kim SU, Huh K, Savage MJ, Masliah E, Mook-Jung I. Blockade of PKC epsilon activation attenuates phorbol ester-induced increase of alpha-secretase-derived secreted form of amyloid precursor protein. Biochemical and Biophysical Research Communications. 280: 782-7. PMID 11162589 DOI: 10.1006/Bbrc.2000.4181  0.392
2001 Masliah E, Mallory M, Alford M, DeTeresa R, Hansen LA, McKeel DW, Morris JC. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology. 56: 127-9. PMID 11148253 DOI: 10.1212/Wnl.56.1.127  0.375
2000 Veinbergs I, Mallory M, Sagara Y, Masliah E. Vitamin E supplementation prevents spatial learning deficits and dendritic alterations in aged apolipoprotein E-deficient mice. The European Journal of Neuroscience. 12: 4541-6. PMID 11122365 DOI: 10.1111/J.1460-9568.2000.01308.X  0.708
2000 Mucke L, Yu GQ, McConlogue L, Rockenstein EM, Abraham CR, Masliah E. Astroglial expression of human alpha(1)-antichymotrypsin enhances alzheimer-like pathology in amyloid protein precursor transgenic mice. The American Journal of Pathology. 157: 2003-10. PMID 11106573 DOI: 10.1016/S0002-9440(10)64839-0  0.457
2000 Wiley CA, Achim CL, Hammond R, Love S, Masliah E, Radhakrishnan L, Sanders V, Wang G. Damage and repair of DNA in HIV encephalitis. Journal of Neuropathology and Experimental Neurology. 59: 955-65. PMID 11089573 DOI: 10.1093/Jnen/59.11.955  0.304
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