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Tamas L. Horvath - Publications

Yale University, New Haven, CT 

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Korchynska S, Rebernik P, Pende M, Boi L, Alpár A, Tasan R, Becker K, Balueva K, Saghafi S, Wulff P, Horvath TL, Fisone G, Dodt HU, Hökfelt T, Harkany T, et al. A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice. Nature Communications. 13: 5944. PMID 36209152 DOI: 10.1038/s41467-022-33584-3  0.317
2022 Xie D, Stutz B, Li F, Chen F, Lv H, Sestan-Pesa M, Catarino J, Gu J, Zhao H, Stoddard CE, Carmichael GG, Shanabrough M, Taylor HS, Liu ZW, Gao XB, ... Horvath TL, et al. TET3 epigenetically controls feeding and stress response behaviors via AGRP neurons. The Journal of Clinical Investigation. 132. PMID 36189793 DOI: 10.1172/JCI162365  0.38
2022 Wang Q, Zhang B, Stutz B, Liu ZW, Horvath TL, Yang X. Ventromedial hypothalamic OGT drives adipose tissue lipolysis and curbs obesity. Science Advances. 8: eabn8092. PMID 36044565 DOI: 10.1126/sciadv.abn8092  0.331
2022 Stutz B, Waterson MJ, Šestan-Peša M, Dietrich MO, Škarica M, Sestan N, Racz B, Magyar A, Sotonyi P, Liu ZW, Gao XB, Matyas F, Stoiljkovic M, Horvath TL. AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry. PMID 35906488 DOI: 10.1038/s41380-022-01691-8  0.794
2022 Jin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Correction: Drp1 is required for AgRP neuronal activity and feeding. Elife. 11. PMID 35763333 DOI: 10.7554/eLife.80570  0.331
2021 Ryu S, Shchukina I, Youm YH, Qing H, Hilliard B, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna K, Horvath TL, Dietrich MO, Artyomov MN, et al. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. Elife. 10. PMID 34151773 DOI: 10.7554/eLife.66522  0.757
2021 Yasumoto Y, Stoiljkovic M, Kim JD, Sestan-Pesa M, Gao XB, Diano S, Horvath TL. Ucp2-dependent microglia-neuronal coupling controls ventral hippocampal circuit function and anxiety-like behavior. Molecular Psychiatry. PMID 33879866 DOI: 10.1038/s41380-021-01105-1  0.302
2021 Varela L, Stutz B, Song JE, Kim JG, Liu ZW, Gao XB, Horvath TL. Hunger-promoting AgRP neurons trigger an astrocyte-mediated feed-forward auto-activation loop in mice. The Journal of Clinical Investigation. PMID 33848272 DOI: 10.1172/JCI144239  0.392
2021 Jin S, Yoon NA, Liu ZW, Song JE, Horvath TL, Kim JD, Diano S. Drp1 is required for AgRP neuronal activity and feeding. Elife. 10. PMID 33689681 DOI: 10.7554/eLife.64351  0.351
2021 Coupé B, Leloup C, Asiedu K, Maillard J, Pénicaud L, Horvath TL, Bouret SG. Defective Autophagy in Sf1 Neurons Perturbs the Metabolic Response to Fasting and Causes Mitochondrial Dysfunction. Molecular Metabolism. 101186. PMID 33571700 DOI: 10.1016/j.molmet.2021.101186  0.313
2021 Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL. Author Correction: AgRP neurons control compulsive exercise and survival in an activity-based anorexia model. Nature Metabolism. PMID 33495625 DOI: 10.1038/s42255-021-00351-5  0.783
2020 Ryu S, Shchukina I, Youm YH, Qing H, Hilliard BK, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna KM, Horvath TL, Dietrich MO, Artyomov MN, et al. Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. Biorxiv : the Preprint Server For Biology. PMID 33236006 DOI: 10.1101/2020.09.11.294363  0.712
2020 Miletta MC, Iyilikci O, Shanabrough M, Šestan-Peša M, Cammisa A, Zeiss CJ, Dietrich MO, Horvath TL. AgRP neurons control compulsive exercise and survival in an activity-based anorexia model. Nature Metabolism. PMID 33106687 DOI: 10.1038/s42255-020-00300-8  0.814
2020 Tan Y, Hang F, Liu ZW, Stoiljkovic M, Wu M, Tu Y, Han W, Lee AM, Kelley C, Hajos M, Lu L, de Lecea L, de Araujo I, Picciotto M, Horvath TL, et al. Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. The Journal of Clinical Investigation. PMID 32516139 DOI: 10.1172/Jci130889  0.611
2020 Yasumoto Y, Horvath TL. Crosstalk between maternal perinatal obesity and offspring dopaminergic circuitry. The Journal of Clinical Investigation. 130: 3416-3418. PMID 32510474 DOI: 10.1172/JCI138123  0.392
2020 Timper K, Del Río-Martín A, Cremer AL, Bremser S, Alber J, Giavalisco P, Varela L, Heilinger C, Nolte H, Trifunovic A, Horvath TL, Kloppenburg P, Backes H, Brüning JC. GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function. Cell Metabolism. PMID 32433922 DOI: 10.1016/j.cmet.2020.05.001  0.341
2020 Dore R, Krotenko R, Reising JP, Murru L, Sundaram SM, Di Spiezio A, Müller-Fielitz H, Schwaninger M, Jöhren O, Mittag J, Passafaro M, Shanabrough M, Horvath TL, Schulz C, Lehnert H. Nesfatin-1 decreases the motivational and rewarding value of food. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32353862 DOI: 10.1038/S41386-020-0682-3  0.413
2020 Kiss DS, Toth I, Jocsak G, Bartha T, Frenyo LV, Barany Z, Horvath TL, Zsarnovszky A. Metabolic Lateralization in the Hypothalamus of Male Rats Related to Reproductive and Satiety States. Reproductive Sciences (Thousand Oaks, Calif.). PMID 32046448 DOI: 10.1007/s43032-019-00131-3  0.319
2019 Berger JM, Singh P, Khrimian L, Morgan DA, Chowdhury S, Arteaga-Solis E, Horvath TL, Domingos AI, Marsland AL, Kumal Yadav V, Rahmouni K, Gao XB, Karsenty G. Mediation of the Acute Stress Response by the Skeleton. Cell Metabolism. PMID 31523009 DOI: 10.1016/J.Cmet.2019.08.012  0.336
2019 Varela L, Horvath TL. Parallel Paths in PVH Control of Feeding. Neuron. 102: 514-516. PMID 31071283 DOI: 10.1016/j.neuron.2019.04.026  0.439
2019 Taylor-Giorlando M, Scheinost D, Ment L, Rothman D, Horvath TL. Prefrontal Cortical and Behavioral Adaptations to Surgical Delivery Mediated by Metabolic Principles. Cerebral Cortex (New York, N.Y. : 1991). PMID 30877804 DOI: 10.1093/Cercor/Bhz046  0.37
2019 Mancini G, Pirruccio K, Yang X, Blücher M, Rodeheffer M, Horvath TL. Mitofusin 2 in Mature Adipocytes Controls Adiposity and Body Weight. Cell Reports. 26: 2849-2858.e4. PMID 30865877 DOI: 10.1016/J.Celrep.2019.02.039  0.354
2019 Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular Metabolism. PMID 30833218 DOI: 10.1016/J.Molmet.2019.02.005  0.441
2019 Miletta MC, Shanabrough M, Sestan-Pesa M, Varela L, Mancini G, Spadaro O, Zeiss C, Dixit V, Dietrich M, Horvath T. SUN-097 AgRP Neurons Determine Survival in Activity-Based Anorexia Model Journal of the Endocrine Society. 3. DOI: 10.1210/Js.2019-Sun-097  0.773
2018 García-Cáceres C, Balland E, Prevot V, Luquet S, Woods SC, Koch M, Horvath TL, Yi CX, Chowen JA, Verkhratsky A, Araque A, Bechmann I, Tschöp MH. Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism. Nature Neuroscience. PMID 30531847 DOI: 10.1038/S41593-018-0286-Y  0.461
2018 Kim KE, Jeong EA, Shin HJ, Lee JY, Choi EB, An HS, Park KA, Jin Z, Lee DK, Horvath TL, Roh GS. Effects of myeloid sirtuin 1 deficiency on hypothalamic neurogranin in mice fed a high-fat diet. Biochemical and Biophysical Research Communications. PMID 30471862 DOI: 10.1016/j.bbrc.2018.11.126  0.341
2018 Tebbenkamp ATN, Varela L, Choi J, Paredes MI, Giani AM, Song JE, Sestan-Pesa M, Franjic D, Sousa AMM, Liu ZW, Li M, Bichsel C, Koch M, Szigeti-Buck K, Liu F, ... ... Horvath TL, et al. The 7q11.23 Protein DNAJC30 Interacts with ATP Synthase and Links Mitochondria to Brain Development. Cell. PMID 30318146 DOI: 10.1016/J.Cell.2018.09.014  0.529
2018 Timper K, Paeger L, Sánchez-Lasheras C, Varela L, Jais A, Nolte H, Vogt MC, Hausen AC, Heilinger C, Evers N, Pospisilik JA, Penninger JM, Taylor EB, Horvath TL, Kloppenburg P, et al. Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity. Cell Reports. 25: 383-397.e10. PMID 30304679 DOI: 10.1016/J.Celrep.2018.09.034  0.438
2018 Stoiljkovic M, Kelley C, Horvath TL, Hajós M. Neurophysiological signals as predictive translational biomarkers for Alzheimer's disease treatment: effects of donepezil on neuronal network oscillations in TgF344-AD rats. Alzheimer's Research & Therapy. 10: 105. PMID 30301466 DOI: 10.1186/S13195-018-0433-4  0.335
2018 Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang ZY, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T. Insulin regulates POMC neuronal plasticity to control glucose metabolism. Elife. 7. PMID 30230471 DOI: 10.1016/J.Orcp.2018.11.064  0.414
2018 Rash BG, Micali N, Huttner AJ, Morozov YM, Horvath TL, Rakic P. Metabolic regulation and glucose sensitivity of cortical radial glial cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 30224493 DOI: 10.1073/Pnas.1808066115  0.311
2018 Alpár A, Zahola P, Hanics J, Hevesi Z, Korchynska S, Benevento M, Pifl C, Zachar G, Perugini J, Severi I, Leitgeb P, Bakker J, Miklosi AG, Tretiakov E, Keimpema E, ... ... Horvath TL, et al. Hypothalamic CNTF volume transmission shapes cortical noradrenergic excitability upon acute stress. The Embo Journal. PMID 30209240 DOI: 10.15252/Embj.2018100087  0.403
2018 Ravussin A, Youm YH, Sander J, Ryu S, Nguyen K, Varela L, Shulman GI, Sidorov S, Horvath TL, Schultze JL, Dixit VD. Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity. Cell Reports. 24: 1085-1092.e6. PMID 30067966 DOI: 10.1016/J.Celrep.2018.06.112  0.34
2018 Kiss DS, Ioja E, Toth I, Barany Z, Jocsak G, Bartha T, Horvath TL, Zsarnovszky A. Comparative Analysis of Zearalenone Effects on Thyroid Receptor Alpha (TRα) and Beta (TRβ) Expression in Rat Primary Cerebellar Cell Cultures. International Journal of Molecular Sciences. 19. PMID 29751674 DOI: 10.3390/ijms19051440  0.319
2018 Miletta MC, Horvath TL. Patient-Derived iPSC-Hypothamic Neurons: The Ultimate Protocol. Cell Stem Cell. 22: 615-616. PMID 29727675 DOI: 10.1016/j.stem.2018.04.019  0.356
2018 Kim KE, Jeong EA, Lee JY, Yi CO, Park KA, Jin Z, Lee JE, Horvath TL, Roh GS. Myeloid sirtuin1 deficiency aggravates hippocampal inflammation in mice fed high-fat diets. Biochemical and Biophysical Research Communications. PMID 29634925 DOI: 10.1016/j.bbrc.2018.04.044  0.306
2018 Miletta MC, Horvath TL. From white to beige: a new hypothalamic pathway. Embo Reports. PMID 29581171 DOI: 10.15252/embr.201845928  0.416
2018 Aryal B, Singh AK, Zhang X, Varela L, Rotllan N, Goedeke L, Chaube B, Camporez JP, Vatner DF, Horvath TL, Shulman GI, Suárez Y, Fernández-Hernando C. Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis. Jci Insight. 3. PMID 29563332 DOI: 10.1172/Jci.Insight.97918  0.304
2018 Varela L, Horvath TL. Neuronal Cilia: Another Player in the Melanocortin System. Trends in Molecular Medicine. PMID 29501261 DOI: 10.1016/j.molmed.2018.02.004  0.422
2018 Dodd GT, Michael NJ, Lee-Young RS, Mangiafico SP, Pryor JT, Munder AC, Simonds SE, Brüning JC, Zhang Z, Cowley MA, Andrikopoulos S, Horvath TL, Spanswick D, Tiganis T. Author response: Insulin regulates POMC neuronal plasticity to control glucose metabolism Elife. DOI: 10.7554/Elife.38704.025  0.368
2017 Hawkins MN, Horvath TL. Cannabis in fat: high hopes to treat obesity. The Journal of Clinical Investigation. PMID 29035279 DOI: 10.1172/JCI97042  0.348
2017 Zsarnovszky A, Kiss D, Jocsak G, Nemeth G, Toth I, Horvath TL. Thyroid hormone- and estrogen receptor interactions with natural ligands and endocrine disruptors in the cerebellum. Frontiers in Neuroendocrinology. PMID 28987779 DOI: 10.1016/j.yfrne.2017.10.001  0.354
2017 Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. Elife. 6. PMID 28762946 DOI: 10.7554/Elife.25755  0.794
2017 Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, ... ... Horvath TL, et al. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nature Neuroscience. PMID 28628102 DOI: 10.1038/Nn.4590  0.425
2017 Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, ... ... Horvath TL, et al. Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control. Cell Metabolism. 25: 1390-1399.e6. PMID 28591639 DOI: 10.1016/j.cmet.2017.05.010  0.437
2017 Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding. Cell. 169: 559. PMID 28431254 DOI: 10.1016/j.cell.2017.04.006  0.775
2017 Morozov YM, Koch M, Rakic P, Horvath TL. Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus. Molecular Metabolism. 6: 374-381. PMID 28377876 DOI: 10.1016/j.molmet.2017.01.004  0.448
2017 Chowen JA, Horvath TL, Argente J. Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean? Diabetes. 66: 804-805. PMID 28325742 DOI: 10.2337/Dbi16-0073  0.34
2017 Varela L, Suyama S, Huang Y, Shanabrough M, Tschoep MH, Gao XB, Giordano FJ, Horvath TL. Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. Diabetes. PMID 28292966 DOI: 10.2337/db16-1106  0.415
2017 Harkany T, Horvath TL. (S)Pot on Mitochondria: Cannabinoids Disrupt Cellular Respiration to Limit Neuronal Activity. Cell Metabolism. 25: 8-10. PMID 28076767 DOI: 10.1016/J.Cmet.2016.12.020  0.411
2017 Suyama S, Ralevski A, Liu Z, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao X, Diano S, Horvath TL. Author response: Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons Elife. DOI: 10.7554/Elife.25755.014  0.762
2016 Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, ... ... Horvath TL, et al. Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes. Nature Neuroscience. PMID 27991900 DOI: 10.1038/Nn.4462  0.461
2016 Gao XB, Horvath TL. Feeding Behavior: Hypocretin/Orexin Neurons Act between Food Seeking and Eating. Current Biology : Cb. 26: R845-R847. PMID 27676302 DOI: 10.1016/j.cub.2016.07.069  0.357
2016 Kumamoto Y, Camporez JP, Jurczak MJ, Shanabrough M, Horvath T, Shulman GI, Iwasaki A. CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha. Immunity. PMID 27566941 DOI: 10.1016/J.Immuni.2016.08.002  0.307
2016 García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, ... ... Horvath TL, et al. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 166: 867-80. PMID 27518562 DOI: 10.1016/J.Cell.2016.07.028  0.302
2016 Jin S, Kim JG, Park JW, Koch M, Horvath TL, Lee BJ. Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis. Scientific Reports. 6: 29424. PMID 27405276 DOI: 10.1038/srep29424  0.412
2016 Hermes G, Nagy D, Waterson M, Zsarnovszky A, Varela L, Hajos M, Horvath TL. Role of mitochondrial uncoupling protein-2 (UCP2) in higher brain functions, neuronal plasticity and network oscillation. Molecular Metabolism. 5: 415-21. PMID 27257601 DOI: 10.1016/J.Molmet.2016.04.002  0.349
2016 Chowen JA, Argente-Arizón P, Freire-Regatillo A, Frago LM, Horvath TL, Argente J. The role of astrocytes in the hypothalamic response and adaptation to metabolic signals. Progress in Neurobiology. PMID 27000556 DOI: 10.1016/J.Pneurobio.2016.03.001  0.38
2016 Barnstable CJ, Reddy R, Li H, Horvath TL. Mitochondrial Uncoupling Protein 2 (UCP2) Regulates Retinal Ganglion Cell Number and Survival. Journal of Molecular Neuroscience : Mn. PMID 26846222 DOI: 10.1007/s12031-016-0728-5  0.331
2016 Varela L, Schwartz ML, Horvath TL. Mitochondria controlled by UCP2 determine hypoxia-induced synaptic remodeling in the cortex and hippocampus. Neurobiology of Disease. PMID 26777666 DOI: 10.1016/j.nbd.2016.01.004  0.415
2016 Sestan-Pesa M, Horvath TL. Metabolism and Mental Illness. Trends in Molecular Medicine. PMID 26776095 DOI: 10.1016/j.molmed.2015.12.003  0.315
2016 Koch M, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Dietrich MO, Diano S, Horvath TL. Novel insights into central regulation of food intake Neuropeptides. 55: 30. DOI: 10.1016/J.Npep.2015.11.086  0.738
2015 Cottrell JR, Li B, Kyung JW, Ashford CJ, Mann JJ, Horvath TL, Ryan TA, Kim SH, Gerber DJ. Calcineurin Aγ is a Functional Phosphatase that Modulates Synaptic Vesicle Endocytosis. The Journal of Biological Chemistry. PMID 26627835 DOI: 10.1074/jbc.M115.705319  0.356
2015 Waterson MJ, Horvath TL. Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding. Cell Metabolism. PMID 26603190 DOI: 10.1016/j.cmet.2015.09.026  0.395
2015 Lerea JS, Ring LE, Hassouna R, Chong AC, Szigeti-Buck K, Horvath TL, Zeltser LM. Reducing adiposity in a critical developmental window has lasting benefits in mice. Endocrinology. en20151753. PMID 26587784 DOI: 10.1210/en.2015-1753  0.321
2015 Kim JG, Sun BH, Dietrich MO, Koch M, Yao GQ, Diano S, Insogna K, Horvath TL. AgRP Neurons Regulate Bone Mass. Cell Reports. PMID 26411686 DOI: 10.1016/J.Celrep.2015.08.070  0.794
2015 Varela L, Horvath TL. A Sympathetic View on Fat by Leptin. Cell. 163: 26-7. PMID 26406366 DOI: 10.1016/j.cell.2015.09.016  0.302
2015 Toth I, Kiss DS, Jocsak G, Somogyi V, Toronyi E, Bartha T, Frenyo LV, Horvath TL, Zsarnovszky A. Estrogen- and Satiety State-Dependent Metabolic Lateralization in the Hypothalamus of Female Rats. Plos One. 10: e0137462. PMID 26339901 DOI: 10.1371/journal.pone.0137462  0.312
2015 Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell. 160: 1222-32. PMID 25748653 DOI: 10.1016/J.Cell.2015.02.024  0.789
2015 Koch M, Varela L, Kim JG, Kim JD, Hernández-Nuño F, Simonds SE, Castorena CM, Vianna CR, Elmquist JK, Morozov YM, Rakic P, Bechmann I, Cowley MA, Szigeti-Buck K, Dietrich MO, ... ... Horvath TL, et al. Hypothalamic POMC neurons promote cannabinoid-induced feeding. Nature. 519: 45-50. PMID 25707796 DOI: 10.1038/Nature14260  0.801
2015 Youm YH, Nguyen KY, Grant RW, Goldberg EL, Bodogai M, Kim D, D'Agostino D, Planavsky N, Lupfer C, Kanneganti TD, Kang S, Horvath TL, Fahmy TM, Crawford PA, Biragyn A, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nature Medicine. 21: 263-9. PMID 25686106 DOI: 10.1038/Nm.3804  0.301
2014 Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL, Yang X. O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell. 159: 306-17. PMID 25303527 DOI: 10.1016/J.Cell.2014.09.010  0.786
2014 Nasrallah CM, Horvath TL. Mitochondrial dynamics in the central regulation of metabolism. Nature Reviews. Endocrinology. 10: 650-8. PMID 25200564 DOI: 10.1038/nrendo.2014.160  0.377
2014 Long L, Toda C, Jeong JK, Horvath TL, Diano S. PPARγ ablation sensitizes proopiomelanocortin neurons to leptin during high-fat feeding. The Journal of Clinical Investigation. 124: 4017-27. PMID 25083994 DOI: 10.1172/Jci76220  0.494
2014 Morozov YM, Horvath TL, Rakic P. A tale of two methods: Identifying neuronal CB1 receptors. Molecular Metabolism. 3: 338. PMID 24944888 DOI: 10.1016/j.molmet.2014.03.006  0.337
2014 Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, ... ... Horvath TL, et al. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nature Neuroscience. 17: 908-10. PMID 24880214 DOI: 10.1038/Nn.3725  0.803
2014 Gao XB, Horvath T. Function and dysfunction of hypocretin/orexin: an energetics point of view. Annual Review of Neuroscience. 37: 101-16. PMID 24821311 DOI: 10.1146/annurev-neuro-071013-013855  0.307
2014 Toth I, Kiss DS, Goszleth G, Bartha T, Frenyo LV, Naftolin F, Horvath TL, Zsarnovszky A. Hypothalamic sidedness in mitochondrial metabolism: new perspectives. Reproductive Sciences (Thousand Oaks, Calif.). 21: 1492-8. PMID 24740989 DOI: 10.1177/1933719114530188  0.367
2014 Koch M, Horvath TL. Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism. Molecular Psychiatry. 19: 752-61. PMID 24732669 DOI: 10.1038/mp.2014.30  0.473
2014 Seli E, Babayev E, Collins SC, Nemeth G, Horvath TL. Minireview: Metabolism of female reproduction: regulatory mechanisms and clinical implications. Molecular Endocrinology (Baltimore, Md.). 28: 790-804. PMID 24678733 DOI: 10.1210/me.2013-1413  0.304
2014 Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Brüning JC. Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding. Cell. 156: 495-509. PMID 24462248 DOI: 10.1016/j.cell.2014.01.008  0.408
2014 Szepietowska B, Horvath TL, Sherwin RS. Role of synaptic plasticity and EphA5-ephrinA5 interaction within the ventromedial hypothalamus in response to recurrent hypoglycemia. Diabetes. 63: 1140-7. PMID 24222347 DOI: 10.2337/Db13-1259  0.303
2013 Domingos AI, Sordillo A, Dietrich MO, Liu ZW, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, de Araujo IE, Friedman JM. Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar. Elife. 2: e01462. PMID 24381247 DOI: 10.7554/Elife.01462  0.782
2013 Peixoto PM, Kim HJ, Sider B, Starkov A, Horvath TL, Manfredi G. UCP2 overexpression worsens mitochondrial dysfunction and accelerates disease progression in a mouse model of amyotrophic lateral sclerosis. Molecular and Cellular Neurosciences. 57: 104-10. PMID 24141050 DOI: 10.1016/J.Mcn.2013.10.002  0.305
2013 Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell. 155: 228-41. PMID 24074871 DOI: 10.1016/J.Cell.2013.08.042  0.334
2013 Dietrich MO, Liu ZW, Horvath TL. Mitochondrial dynamics controlled by mitofusins regulate Agrp neuronal activity and diet-induced obesity. Cell. 155: 188-99. PMID 24074868 DOI: 10.1016/J.Cell.2013.09.004  0.802
2013 Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, et al. Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance. Cell. 155: 172-87. PMID 24074867 DOI: 10.1016/J.Cell.2013.09.003  0.771
2013 Seli E, Horvath TL. Natural birth-induced UCP2 in brain development. Reviews in Endocrine & Metabolic Disorders. 14: 347-50. PMID 23979530 DOI: 10.1007/s11154-013-9262-8  0.326
2013 Hess ME, Hess S, Meyer KD, Verhagen LA, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O, Belgardt BF, Franz T, Horvath TL, Rüther U, Jaffrey SR, et al. The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. Nature Neuroscience. 16: 1042-8. PMID 23817550 DOI: 10.1038/Nn.3449  0.765
2013 Chowen JA, Argente J, Horvath TL. Uncovering novel roles of nonneuronal cells in body weight homeostasis and obesity. Endocrinology. 154: 3001-7. PMID 23798599 DOI: 10.1210/En.2013-1303  0.365
2013 Matarese G, Procaccini C, Menale C, Kim JG, Kim JD, Diano S, Diano N, De Rosa V, Dietrich MO, Horvath TL. Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 6193-8. PMID 23530205 DOI: 10.1073/Pnas.1210644110  0.776
2013 Rao Y, Mineur YS, Gan G, Wang AH, Liu ZW, Wu X, Suyama S, de Lecea L, Horvath TL, Picciotto MR, Gao XB. Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice. The Journal of Physiology. 591: 1951-66. PMID 23318871 DOI: 10.1113/jphysiol.2012.246983  0.581
2013 Dietrich MO, Horvath TL. Hypothalamic control of energy balance: insights into the role of synaptic plasticity. Trends in Neurosciences. 36: 65-73. PMID 23318157 DOI: 10.1016/J.Tins.2012.12.005  0.791
2013 Domingos AI, Sordillo A, Dietrich MO, Liu Z, Tellez LA, Vaynshteyn J, Ferreira JG, Ekstrand MI, Horvath TL, Araujo IEd, Friedman JM. Author response: Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar Elife. DOI: 10.7554/Elife.01462.019  0.768
2013 Ren H, Orozco I, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath T, Wardlaw S, Plum L, Arancio O, Accili D. FoxO1 Target Gpr17 Activates AgRP Neurons to Regulate Food Intake Cell. 153: 1166. DOI: 10.1016/J.Cell.2013.05.010  0.41
2012 Horvath TL, Abizaid A, Dietrich MO, Li Y, Takahashi JS, Bass J. Ghrelin-immunopositive hypothalamic neurons tie the circadian clock and visual system to the lateral hypothalamic arousal center. Molecular Metabolism. 1: 79-85. PMID 24024121 DOI: 10.1016/J.Molmet.2012.08.003  0.815
2012 Abizaid A, Horvath TL. Ghrelin and the central regulation of feeding and energy balance. Indian Journal of Endocrinology and Metabolism. 16: S617-26. PMID 23565498 DOI: 10.4103/2230-8210.105580  0.538
2012 Dietrich MO, Horvath TL. A marriage made to last in drug design. Nature Medicine. 18: 1737-8. PMID 23223057 DOI: 10.1038/Nm.3018  0.744
2012 Dietrich MO, Horvath TL. Phosphoribosomes for fingerprinting neurons. Cell. 151: 934-6. PMID 23178116 DOI: 10.1016/J.Cell.2012.11.006  0.786
2012 Varela L, Horvath TL. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. Embo Reports. 13: 1079-86. PMID 23146889 DOI: 10.1038/embor.2012.174  0.384
2012 Varela L, Horvath TL. AgRP neurons: a switch between peripheral carbohydrate and lipid utilization. The Embo Journal. 31: 4252-4. PMID 23085989 DOI: 10.1038/emboj.2012.287  0.429
2012 Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA. Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes. The Journal of Clinical Investigation. 122: 3900-13. PMID 23064363 DOI: 10.1172/Jci64102  0.784
2012 Simon-Areces J, Dietrich MO, Hermes G, Garcia-Segura LM, Arevalo MA, Horvath TL. UCP2 induced by natural birth regulates neuronal differentiation of the hippocampus and related adult behavior. Plos One. 7: e42911. PMID 22905184 DOI: 10.1371/Journal.Pone.0042911  0.787
2012 Kim JG, Horvath TL. mTOR signaling fades POMC neurons during aging. Neuron. 75: 356-7. PMID 22884318 DOI: 10.1016/j.neuron.2012.07.017  0.457
2012 Dietrich MO, Horvath TL. Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons. Nature Reviews. Drug Discovery. 11: 675-91. PMID 22858652 DOI: 10.1038/Nrd3739  0.764
2012 Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiological Reviews. 92: 1479-514. PMID 22811431 DOI: 10.1152/Physrev.00022.2011  0.76
2012 Dietrich MO, Bober J, Ferreira JG, Tellez LA, Mineur YS, Souza DO, Gao XB, Picciotto MR, Araújo I, Liu ZW, Horvath TL. AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. Nature Neuroscience. 15: 1108-10. PMID 22729177 DOI: 10.1038/Nn.3147  0.819
2012 Ren H, Orozco IJ, Su Y, Suyama S, Gutiérrez-Juárez R, Horvath TL, Wardlaw SL, Plum L, Arancio O, Accili D. FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell. 149: 1314-26. PMID 22682251 DOI: 10.1016/j.cell.2012.04.032  0.358
2012 Dietrich MO, Horvath TL. Fat incites tanycytes to neurogenesis. Nature Neuroscience. 15: 651-3. PMID 22534576 DOI: 10.1038/Nn.3091  0.782
2012 Dietrich MO, Horvath TL. AgRP neurons: the foes of reproduction in leptin-deficient obese subjects. Proceedings of the National Academy of Sciences of the United States of America. 109: 2699-700. PMID 22323603 DOI: 10.1073/Pnas.1121355109  0.763
2012 Coupé B, Ishii Y, Dietrich MO, Komatsu M, Horvath TL, Bouret SG. Loss of autophagy in pro-opiomelanocortin neurons perturbs axon growth and causes metabolic dysregulation. Cell Metabolism. 15: 247-55. PMID 22285542 DOI: 10.1016/J.Cmet.2011.12.016  0.803
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, ... Horvath TL, et al. Obesity is associated with hypothalamic injury in rodents and humans. The Journal of Clinical Investigation. 122: 153-62. PMID 22201683 DOI: 10.1172/Jci59660  0.772
2012 Diano S, Horvath TL. Mitochondrial uncoupling protein 2 (UCP2) in glucose and lipid metabolism. Trends in Molecular Medicine. 18: 52-8. PMID 21917523 DOI: 10.1016/J.Molmed.2011.08.003  0.326
2012 Dietrich MO, Horvath TL. Neuroendocrine Regulation of Energy Metabolism Endocrinology and Metabolism. 27: 268. DOI: 10.3803/Enm.2012.27.4.268  0.776
2012 Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, ... Horvath TL, et al. Obesity is associated with hypothalamic injury in rodents and humans (The Journal of Clinical Investigation (2012) 122, 1, (153-162) DOI: 10.1172/JCI59660) Journal of Clinical Investigation. 122: 778. DOI: 10.1172/Jci62813  0.724
2011 Fujino T, Leslie JH, Eavri R, Chen JL, Lin WC, Flanders GH, Borok E, Horvath TL, Nedivi E. CPG15 regulates synapse stability in the developing and adult brain. Genes & Development. 25: 2674-85. PMID 22190461 DOI: 10.1101/Gad.176172.111  0.301
2011 Dietrich MO, Horvath TL. Synaptic plasticity of feeding circuits: hormones and hysteresis. Cell. 146: 863-5. PMID 21925311 DOI: 10.1016/J.Cell.2011.08.031  0.783
2011 Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, ... ... Horvath TL, et al. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine. 17: 1121-7. PMID 21873987 DOI: 10.1038/Nm.2421  0.806
2011 Abizaid A, Mineur YS, Roth RH, Elsworth JD, Sleeman MW, Picciotto MR, Horvath TL. Reduced locomotor responses to cocaine in ghrelin-deficient mice. Neuroscience. 192: 500-6. PMID 21699961 DOI: 10.1016/J.Neuroscience.2011.06.001  0.623
2011 Bi B, Salmaso N, Komitova M, Simonini MV, Silbereis J, Cheng E, Kim J, Luft S, Ment LR, Horvath TL, Schwartz ML, Vaccarino FM. Cortical glial fibrillary acidic protein-positive cells generate neurons after perinatal hypoxic injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9205-21. PMID 21697371 DOI: 10.1523/Jneurosci.0518-11.2011  0.371
2011 Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gündisch D, Diano S, De Biasi M, Horvath TL, Gao XB, Picciotto MR. Nicotine decreases food intake through activation of POMC neurons. Science (New York, N.Y.). 332: 1330-2. PMID 21659607 DOI: 10.1126/Science.1201889  0.658
2011 Klöckener T, Hess S, Belgardt BF, Paeger L, Verhagen LA, Husch A, Sohn JW, Hampel B, Dhillon H, Zigman JM, Lowell BB, Williams KW, Elmquist JK, Horvath TL, Kloppenburg P, et al. High-fat feeding promotes obesity via insulin receptor/PI3K-dependent inhibition of SF-1 VMH neurons. Nature Neuroscience. 14: 911-8. PMID 21642975 DOI: 10.1038/Nn.2847  0.431
2011 Wiedmer P, Strasser F, Horvath TL, Blum D, Dimarchi R, Lutz T, Schürmann A, Joost HG, Tschöp MH, Tong J. Ghrelin-induced hypothermia: a physiological basis but no clinical risk. Physiology & Behavior. 105: 43-51. PMID 21513721 DOI: 10.1016/J.Physbeh.2011.03.027  0.334
2011 Ravussin Y, Gutman R, Diano S, Shanabrough M, Borok E, Sarman B, Lehmann A, LeDuc CA, Rosenbaum M, Horvath TL, Leibel RL. Effects of chronic weight perturbation on energy homeostasis and brain structure in mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R1352-62. PMID 21411766 DOI: 10.1152/Ajpregu.00429.2010  0.352
2011 Horvath TL, Erion DM, Elsworth JD, Roth RH, Shulman GI, Andrews ZB. GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function. Neurobiology of Disease. 43: 152-62. PMID 21406233 DOI: 10.1016/J.Nbd.2011.03.005  0.351
2011 García-Cáceres C, Fuente-Martán E, Burgos-Ramos E, Granado M, Frago LM, Barrios V, Horvath T, Argente J, Chowen JA. Differential acute and chronic effects of leptin on hypothalamic astrocyte morphology and synaptic protein levels Endocrinology. 152: 1809-1818. PMID 21343257 DOI: 10.1210/En.2010-1252  0.391
2011 Gao XB, Horvath TL. An arousing discovery on catalepsy: orexin regulates vestibular motor functions. Neuron. 69: 588-90. PMID 21338870 DOI: 10.1016/j.neuron.2011.02.017  0.308
2011 Gerashchenko D, Horvath TL, Xie XS. Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats. Neuropharmacology. 60: 543-9. PMID 21195099 DOI: 10.1016/j.neuropharm.2010.12.026  0.406
2011 Diano S, Liu Z, Jeong JK, Dietrich MO, Ruan H, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, ... ... Horvath TL, et al. Erratum: Corrigendum: Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity Nature Medicine. 17: 1320-1320. DOI: 10.1038/Nm1011-1320A  0.731
2011 Horvath T. A Role for hunger-promoting neurons in the etiology of neurodegeneration Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2326  0.437
2010 Zheng Q, Zhu J, Shanabrough M, Borok E, Benoit SC, Horvath TL, Clegg DJ, Reizes O. Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice. Neuroscience. 171: 1032-40. PMID 20923696 DOI: 10.1016/J.Neuroscience.2010.09.060  0.462
2010 Gyengesi E, Liu ZW, D'Agostino G, Gan G, Horvath TL, Gao XB, Diano S. Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice. Endocrinology. 151: 5395-402. PMID 20843996 DOI: 10.1210/En.2010-0681  0.421
2010 Dietrich MO, Antunes C, Geliang G, Liu ZW, Borok E, Nie Y, Xu AW, Souza DO, Gao Q, Diano S, Gao XB, Horvath TL. Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11815-25. PMID 20810901 DOI: 10.1523/Jneurosci.2234-10.2010  0.834
2010 Sotonyi P, Mezei G, Racz B, Dallman MF, Abizaid A, Horvath TL. Gonadotropin-releasing hormone fibers contact POMC neurons in the hypothalamic arcuate nucleus. Reproductive Sciences (Thousand Oaks, Calif.). 17: 1024-8. PMID 20713970 DOI: 10.1177/1933719110378346  0.599
2010 Sotonyi P, Gao Q, Bechmann I, Horvath TL. Estrogen promotes parvalbumin expression in arcuate nucleus POMC neurons. Reproductive Sciences (Thousand Oaks, Calif.). 17: 1077-80. PMID 20713969 DOI: 10.1177/1933719110379651  0.461
2010 Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, et al. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proceedings of the National Academy of Sciences of the United States of America. 107: 14875-80. PMID 20679202 DOI: 10.1073/Pnas.1004282107  0.439
2010 Matarese G, Procaccini C, De Rosa V, Horvath TL, La Cava A. Regulatory T cells in obesity: the leptin connection. Trends in Molecular Medicine. 16: 247-56. PMID 20493774 DOI: 10.1016/j.molmed.2010.04.002  0.329
2010 Stevens HE, Smith KM, Maragnoli ME, Fagel D, Borok E, Shanabrough M, Horvath TL, Vaccarino FM. Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5590-602. PMID 20410112 DOI: 10.1523/Jneurosci.5837-09.2010  0.428
2010 Andrews ZB, Erion DM, Beiler R, Choi CS, Shulman GI, Horvath TL. Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology. 151: 2078-86. PMID 20189996 DOI: 10.1210/En.2009-0850  0.335
2010 Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram TZ. Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 703-13. PMID 20071535 DOI: 10.1523/Jneurosci.4214-09.2010  0.425
2010 Lin HV, Plum L, Ono H, Gutiérrez-Juárez R, Shanabrough M, Borok E, Horvath TL, Rossetti L, Accili D. Divergent regulation of energy expenditure and hepatic glucose production by insulin receptor in agouti-related protein and POMC neurons. Diabetes. 59: 337-46. PMID 19933998 DOI: 10.2337/Db09-1303  0.413
2010 Dietrich MO, Horvath TL. The role of mitochondrial uncoupling proteins in lifespan. PflüGers Archiv : European Journal of Physiology. 459: 269-75. PMID 19760284 DOI: 10.1007/S00424-009-0729-0  0.731
2009 Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 14057-65. PMID 19906954 DOI: 10.1523/Jneurosci.3890-09.2009  0.56
2009 Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, et al. Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metabolism. 10: 355-65. PMID 19883614 DOI: 10.1016/J.Cmet.2009.09.002  0.805
2009 Dietrich MO, Horvath TL. Feeding signals and brain circuitry. The European Journal of Neuroscience. 30: 1688-96. PMID 19878280 DOI: 10.1111/J.1460-9568.2009.06963.X  0.778
2009 Yadav VK, Oury F, Suda N, Liu ZW, Gao XB, Confavreux C, Klemenhagen KC, Tanaka KF, Gingrich JA, Guo XE, Tecott LH, Mann JJ, Hen R, Horvath TL, Karsenty G. A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. Cell. 138: 976-89. PMID 19737523 DOI: 10.1016/J.Cell.2009.06.051  0.435
2009 Blum ID, Patterson Z, Khazall R, Lamont EW, Sleeman MW, Horvath TL, Abizaid A. Reduced anticipatory locomotor responses to scheduled meals in ghrelin receptor deficient mice. Neuroscience. 164: 351-9. PMID 19666088 DOI: 10.1016/J.Neuroscience.2009.08.009  0.782
2009 Leinninger GM, Jo YH, Leshan RL, Louis GW, Yang H, Barrera JG, Wilson H, Opland DM, Faouzi MA, Gong Y, Jones JC, Rhodes CJ, Chua S, Diano S, Horvath TL, et al. Leptin acts via leptin receptor-expressing lateral hypothalamic neurons to modulate the mesolimbic dopamine system and suppress feeding. Cell Metabolism. 10: 89-98. PMID 19656487 DOI: 10.1016/J.Cmet.2009.06.011  0.461
2009 Dietrich MO, Horvath TL. GABA keeps up an appetite for life. Cell. 137: 1177-9. PMID 19563747 DOI: 10.1016/J.Cell.2009.06.002  0.785
2009 Nie Y, Erion DM, Yuan Z, Dietrich M, Shulman GI, Horvath TL, Gao Q. STAT3 inhibition of gluconeogenesis is downregulated by SirT1. Nature Cell Biology. 11: 492-500. PMID 19295512 DOI: 10.1038/Ncb1857  0.743
2009 Tan O, Fadiel A, Chang A, Demir N, Jeffrey R, Horvath T, Garcia-Segura LM, Naftolin F. Estrogens regulate posttranslational modification of neural cell adhesion molecule during the estrogen-induced gonadotropin surge. Endocrinology. 150: 2783-90. PMID 19282389 DOI: 10.1210/en.2008-0927  0.335
2009 Andrews ZB, Horvath TL. Uncoupling protein-2 regulates lifespan in mice. American Journal of Physiology. Endocrinology and Metabolism. 296: E621-7. PMID 19141680 DOI: 10.1152/ajpendo.90903.2008  0.307
2009 Horvath TL, Andrews ZB, Diano S. Fuel utilization by hypothalamic neurons: roles for ROS. Trends in Endocrinology and Metabolism: Tem. 20: 78-87. PMID 19084428 DOI: 10.1016/J.Tem.2008.10.003  0.445
2009 Abizaid A, Horvath TL. Hierarchy of neural pathways controlling energy homeostasis Peptides in Energy Balance and Obesity: Frontiers in Nutritional Science. 263-284.  0.416
2008 Gillum MP, Zhang D, Zhang XM, Erion DM, Jamison RA, Choi C, Dong J, Shanabrough M, Duenas HR, Frederick DW, Hsiao JJ, Horvath TL, Lo CM, Tso P, Cline GW, et al. N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake. Cell. 135: 813-24. PMID 19041747 DOI: 10.1016/J.Cell.2008.10.043  0.325
2008 Dietrich MO, Andrews ZB, Horvath TL. Exercise-induced synaptogenesis in the hippocampus is dependent on UCP2-regulated mitochondrial adaptation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10766-71. PMID 18923051 DOI: 10.1523/Jneurosci.2744-08.2008  0.777
2008 Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 454: 846-51. PMID 18668043 DOI: 10.1038/Nature07181  0.502
2008 Abizaid A, Horvath TL. Brain circuits regulating energy homeostasis. Regulatory Peptides. 149: 3-10. PMID 18514925 DOI: 10.1016/j.regpep.2007.10.006  0.583
2008 Andrews ZB, Horvath TL. Tasteless food reward. Neuron. 57: 806-8. PMID 18367081 DOI: 10.1016/j.neuron.2008.03.004  0.357
2008 Gao Q, Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus. American Journal of Physiology. Endocrinology and Metabolism. 294: E817-26. PMID 18334610 DOI: 10.1152/ajpendo.00733.2007  0.372
2008 Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, et al. Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology. 149: 3009-15. PMID 18308842 DOI: 10.1210/En.2007-1684  0.395
2008 Deierborg T, Deierborg Olsson T, Wieloch T, Diano S, Warden CH, Horvath TL, Mattiasson G. Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1186-95. PMID 18301432 DOI: 10.1038/Jcbfm.2008.8  0.368
2008 Diano S, Horvath TL. Anticonvulsant effects of leptin in epilepsy. The Journal of Clinical Investigation. 118: 26-8. PMID 18097479 DOI: 10.1172/Jci34511  0.364
2008 Gao Q, Horvath TL. Neuronal control of energy homeostasis. Febs Letters. 582: 132-41. PMID 18061579 DOI: 10.1016/j.febslet.2007.11.063  0.466
2008 Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G610-8. PMID 18048479 DOI: 10.1152/Ajpgi.00321.2007  0.365
2008 Deierborg T, Wieloch T, Diano S, Warden CH, Horvath TL, Mattiasson G. Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse (Journal of Cerebral Blood Flow and Metabolism (2008) 28 (1186-1195) DOI: 10.1038/jcbfm.2008.8) Journal of Cerebral Blood Flow and Metabolism. 28: 1273. DOI: 10.1038/Jcbfm.2008.18  0.347
2007 Rao Y, Liu ZW, Borok E, Rabenstein RL, Shanabrough M, Lu M, Picciotto MR, Horvath TL, Gao XB. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons. The Journal of Clinical Investigation. 117: 4022-33. PMID 18060037 DOI: 10.1172/JCI32829  0.573
2007 Plum L, Rother E, Münzberg H, Wunderlich FT, Morgan DA, Hampel B, Shanabrough M, Janoschek R, Könner AC, Alber J, Suzuki A, Krone W, Horvath TL, Rahmouni K, Brüning JC. Enhanced leptin-stimulated Pi3k activation in the CNS promotes white adipose tissue transdifferentiation. Cell Metabolism. 6: 431-45. PMID 18054313 DOI: 10.1016/j.cmet.2007.10.012  0.379
2007 Naftolin F, Garcia-Segura LM, Horvath TL, Zsarnovszky A, Demir N, Fadiel A, Leranth C, Vondracek-Klepper S, Lewis C, Chang A, Parducz A. Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge. Reproductive Sciences (Thousand Oaks, Calif.). 14: 101-16. PMID 17636222 DOI: 10.1177/1933719107301059  0.359
2007 Gao Q, Horvath TL. Neurobiology of feeding and energy expenditure. Annual Review of Neuroscience. 30: 367-98. PMID 17506645 DOI: 10.1146/annurev.neuro.30.051606.094324  0.392
2007 Gao Q, Mezei G, Nie Y, Rao Y, Choi CS, Bechmann I, Leranth C, Toran-Allerand D, Priest CA, Roberts JL, Gao XB, Mobbs C, Shulman GI, Diano S, Horvath TL. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals. Nature Medicine. 13: 89-94. PMID 17195839 DOI: 10.1038/Nm1525  0.429
2007 Coppola A, Liu ZW, Andrews ZB, Paradis E, Roy MC, Friedman JM, Ricquier D, Richard D, Horvath TL, Gao XB, Diano S. A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metabolism. 5: 21-33. PMID 17189204 DOI: 10.1016/J.Cmet.2006.12.002  0.428
2007 Downs JL, Dunn MR, Borok E, Shanabrough M, Horvath TL, Kohama SG, Urbanski HF. Orexin neuronal changes in the locus coeruleus of the aging rhesus macaque. Neurobiology of Aging. 28: 1286-95. PMID 16870307 DOI: 10.1016/J.Neurobiolaging.2006.05.025  0.362
2006 Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. The Journal of Clinical Investigation. 116: 3229-39. PMID 17060947 DOI: 10.1172/Jci29867  0.717
2006 Horvath TL. Synaptic plasticity in energy balance regulation. Obesity (Silver Spring, Md.). 14: 228S-233S. PMID 17021372 DOI: 10.1038/oby.2006.314  0.436
2006 Abizaid A, Gao Q, Horvath TL. Thoughts for food: brain mechanisms and peripheral energy balance. Neuron. 51: 691-702. PMID 16982416 DOI: 10.1016/j.neuron.2006.08.025  0.531
2006 Andrews ZB, Rivera A, Elsworth JD, Roth RH, Agnati L, Gago B, Abizaid A, Schwartz M, Fuxe K, Horvath TL. Uncoupling protein-2 promotes nigrostriatal dopamine neuronal function. The European Journal of Neuroscience. 24: 32-6. PMID 16882005 DOI: 10.1111/J.1460-9568.2006.04906.X  0.533
2006 Gastinger MJ, Tian N, Horvath T, Marshak DW. Retinopetal axons in mammals: emphasis on histamine and serotonin. Current Eye Research. 31: 655-67. PMID 16877274 DOI: 10.1080/02713680600776119  0.318
2006 Horvath TL. Synaptic plasticity mediating leptin's effect on metabolism. Progress in Brain Research. 153: 47-55. PMID 16876567 DOI: 10.1016/S0079-6123(06)53002-X  0.353
2006 Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, ... ... Horvath T, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 51: 239-49. PMID 16846858 DOI: 10.1016/J.Neuron.2006.06.004  0.377
2006 Janoschek R, Plum L, Koch L, Münzberg H, Diano S, Shanabrough M, Müller W, Horvath TL, Brüning JC. gp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor. Proceedings of the National Academy of Sciences of the United States of America. 103: 10707-12. PMID 16818888 DOI: 10.1073/Pnas.0600425103  0.459
2006 Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, ... ... Horvath TL, et al. Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. The Journal of Clinical Investigation. 116: 1886-901. PMID 16794735 DOI: 10.1172/Jci27123  0.47
2006 Horvath TL. The unfolding cannabinoid story on energy homeostasis: central or peripheral site of action? International Journal of Obesity (2005). 30: S30-2. PMID 16570102 DOI: 10.1038/sj.ijo.0803275  0.361
2006 Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, ... ... Horvath TL, et al. Ghrelin controls hippocampal spine synapse density and memory performance. Nature Neuroscience. 9: 381-8. PMID 16491079 DOI: 10.1038/Nn1656  0.333
2006 Horvath TL, Bruning JC. Developmental programming of the hypothalamus: a matter of fat. Nature Medicine. 12: 52-3; discussion 53. PMID 16397567 DOI: 10.1038/nm0106-52  0.333
2006 Rivera A, Agnati LF, Horvath TL, Valderrama JJ, de La Calle A, Fuxe K. Uncoupling protein 2/3 immunoreactivity and the ascending dopaminergic and noradrenergic neuronal systems: relevance for volume transmission. Neuroscience. 137: 1447-61. PMID 16387447 DOI: 10.1016/j.neuroscience.2005.05.051  0.317
2006 Cota D, Tschöp MH, Horvath TL, Levine AS. Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Research Reviews. 51: 85-107. PMID 16364446 DOI: 10.1016/J.Brainresrev.2005.10.004  0.331
2006 Plum L, Ma X, Hampel B, Münzberg H, Shanabrough M, Rother E, Koch L, Janoschek R, Alber J, Belgardt B, Krone W, Horvath T, Ashcroft F, Brüning J. Enhanced PIP3 signaling in POMC neurons causes diet-sensitive obesity as the consequence of neuronal silencing via KATP channel activation Diabetologie Und Stoffwechsel. 1. DOI: 10.1055/s-2006-943791  0.32
2006 Abizaid A, Horvath TL. Rimonabant - A new hope in the treatment of obesity? Commentary Nature Clinical Practice Endocrinology and Metabolism. 2: 370-371. DOI: 10.1038/ncpendmet0218  0.464
2005 Andrews ZB, Diano S, Horvath TL. Mitochondrial uncoupling proteins in the CNS: in support of function and survival. Nature Reviews. Neuroscience. 6: 829-40. PMID 16224498 DOI: 10.1038/Nrn1767  0.391
2005 Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath TL, Culler MD. A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain. Neuroendocrinology. 81: 339-49. PMID 16210868 DOI: 10.1159/000088796  0.509
2005 Gropp E, Shanabrough M, Borok E, Xu AW, Janoschek R, Buch T, Plum L, Balthasar N, Hampel B, Waisman A, Barsh GS, Horvath TL, Brüning JC. Agouti-related peptide-expressing neurons are mandatory for feeding. Nature Neuroscience. 8: 1289-91. PMID 16158063 DOI: 10.1038/nn1548  0.459
2005 Horvath TL, Gao XB. Input organization and plasticity of hypocretin neurons: possible clues to obesity's association with insomnia. Cell Metabolism. 1: 279-86. PMID 16054072 DOI: 10.1016/j.cmet.2005.03.003  0.463
2005 Castañeda TR, Jürgens H, Wiedmer P, Pfluger P, Diano S, Horvath TL, Tang-Christensen M, Tschöp MH. Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. The Journal of Nutrition. 135: 1314-9. PMID 15867332 DOI: 10.1093/Jn/135.5.1314  0.332
2005 Horvath TL. The hardship of obesity: a soft-wired hypothalamus. Nature Neuroscience. 8: 561-5. PMID 15856063 DOI: 10.1038/nn1453  0.359
2005 Abizaid A, Mezei G, Thanarajasingam G, Horvath TL. Estrogen enhances light-induced activation of dorsal raphe serotonergic neurons. The European Journal of Neuroscience. 21: 1536-46. PMID 15845081 DOI: 10.1111/j.1460-9568.2005.03964.x  0.537
2005 Conti B, Sugama S, Lucero J, Winsky-Sommerer R, Wirz SA, Maher P, Andrews Z, Barr AM, Morale MC, Paneda C, Pemberton J, Gaidarova S, Behrens MM, Beal F, Sanna PP, ... Horvath T, et al. Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6-methyl-phenyl-tetrahydropyridine toxicity. Journal of Neurochemistry. 93: 493-501. PMID 15816872 DOI: 10.1111/J.1471-4159.2005.03052.X  0.404
2005 Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Elseworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL. Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 184-91. PMID 15634780 DOI: 10.1523/Jneurosci.4269-04.2005  0.342
2005 Abizaid A, Horvath TL. Unraveling neuronal circuitry regulating energy homeostasis: Plasticity in feeding circuits Drug Discovery Today: Disease Models. 2: 191-196. DOI: 10.1016/j.ddmod.2005.08.009  0.574
2005 Horvath TL. The anatomy of hypocretin neurons Hypocretins: Integrators of Physiological Functions. 77-93. DOI: 10.1007/0-387-25446-3_6  0.315
2004 Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 11439-48. PMID 15601950 DOI: 10.1523/Jneurosci.3459-04.2004  0.413
2004 Abizaid A, Horvath B, Keefe DL, Leranth C, Horvath TL. Direct visual and circadian pathways target neuroendocrine cells in primates. The European Journal of Neuroscience. 20: 2767-76. PMID 15548220 DOI: 10.1111/J.1460-9568.2004.03737.X  0.558
2004 Halem HA, Taylor JE, Dong JZ, Shen Y, Datta R, Abizaid A, Diano S, Horvath T, Zizzari P, Bluet-Pajot MT, Epelbaum J, Culler MD. Novel analogs of ghrelin: physiological and clinical implications. European Journal of Endocrinology / European Federation of Endocrine Societies. 151: S71-5. PMID 15339248 DOI: 10.1530/Eje.0.151S071  0.543
2004 Horvath TL, Diano S. The floating blueprint of hypothalamic feeding circuits. Nature Reviews. Neuroscience. 5: 662-7. PMID 15263896 DOI: 10.1038/Nrn1479  0.353
2004 Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. 145: 4645-52. PMID 15231700 DOI: 10.1210/en.2004-0529  0.378
2004 Horvath TL, Diano S, Tschöp M. Brain circuits regulating energy homeostasis. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 10: 235-46. PMID 15155062 DOI: 10.1177/1073858403262151  0.384
2004 Abizaid A, Mezei G, Sotonyi P, Horvath TL. Sex differences in adult suprachiasmatic nucleus neurons emerging late prenatally in rats. The European Journal of Neuroscience. 19: 2488-96. PMID 15128402 DOI: 10.1111/j.0953-816X.2004.03359.x  0.523
2004 Abizaid A, Mezei G, Horvath TL. Estradiol enhances light-induced expression of transcription factors in the SCN. Brain Research. 1010: 35-44. PMID 15126115 DOI: 10.1016/j.brainres.2004.01.089  0.503
2004 Gao Q, Wolfgang MJ, Neschen S, Morino K, Horvath TL, Shulman GI, Fu XY. Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation. Proceedings of the National Academy of Sciences of the United States of America. 101: 4661-6. PMID 15070774 DOI: 10.1073/Pnas.0303992101  0.38
2004 Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (New York, N.Y.). 304: 110-5. PMID 15064421 DOI: 10.1126/Science.1089459  0.481
2004 Saldanha CJ, Schlinger BA, Micevych PE, Horvath TL. Presynaptic N-methyl-D-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus. The Journal of Comparative Neurology. 469: 522-34. PMID 14755533 DOI: 10.1002/Cne.11035  0.382
2003 Diano S, Matthews RT, Patrylo P, Yang L, Beal MF, Barnstable CJ, Horvath TL. Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning. Endocrinology. 144: 5014-21. PMID 12960023 DOI: 10.1210/En.2003-0667  0.348
2003 Diano S, Horvath B, Urbanski HF, Sotonyi P, Horvath TL. Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets. Endocrinology. 144: 3774-8. PMID 12933647 DOI: 10.1210/En.2003-0274  0.399
2003 Horvath TL. Endocannabinoids and the regulation of body fat: the smoke is clearing. The Journal of Clinical Investigation. 112: 323-6. PMID 12897199 DOI: 10.1172/JCI19376  0.323
2003 Horvath TL, Diano S, Barnstable C. Mitochondrial uncoupling protein 2 in the central nervous system: neuromodulator and neuroprotector. Biochemical Pharmacology. 65: 1917-21. PMID 12787871 DOI: 10.1016/S0006-2952(03)00143-6  0.328
2003 Horvath TL, Castañeda T, Tang-Christensen M, Pagotto U, Tschöp MH. Ghrelin as a potential anti-obesity target. Current Pharmaceutical Design. 9: 1383-95. PMID 12769730 DOI: 10.2174/1381612033454748  0.347
2003 Horvath TL, Diano S, Tschöp M. Ghrelin in hypothalamic regulation of energy balance. Current Topics in Medicinal Chemistry. 3: 921-7. PMID 12678840 DOI: 10.2174/1568026033452230  0.339
2003 Horvath TL, Diano S, Miyamoto S, Barry S, Gatti S, Alberati D, Livak F, Lombardi A, Moreno M, Goglia F, Mor G, Hamilton J, Kachinskas D, Horwitz B, Warden CH. Uncoupling proteins-2 and 3 influence obesity and inflammation in transgenic mice. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association For the Study of Obesity. 27: 433-42. PMID 12664076 DOI: 10.1038/Sj.Ijo.0802257  0.304
2003 Parducz A, Zsarnovszky A, Naftolin F, Horvath TL. Estradiol affects axo-somatic contacts of neuroendocrine cells in the arcuate nucleus of adult rats. Neuroscience. 117: 791-4. PMID 12654332 DOI: 10.1016/S0306-4522(02)00967-3  0.407
2003 Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, ... ... Horvath TL, et al. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 37: 649-61. PMID 12597862 DOI: 10.1016/S0896-6273(03)00063-1  0.433
2003 Hung AJ, Stanbury MG, Shanabrough M, Horvath TL, Garcia-Segura LM, Naftolin F. Estrogen, synaptic plasticity and hypothalamic reproductive aging. Experimental Gerontology. 38: 53-9. PMID 12543261 DOI: 10.1016/S0531-5565(02)00183-3  0.308
2002 Toran-Allerand CD, Guan X, MacLusky NJ, Horvath TL, Diano S, Singh M, Connolly ES, Nethrapalli IS, Tinnikov AA. ER-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development and after ischemic brain injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8391-401. PMID 12351713 DOI: 10.1523/Jneurosci.22-19-08391.2002  0.312
2002 Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochemical Pharmacology. 64: 363-7. PMID 12147286 DOI: 10.1016/S0006-2952(02)01166-8  0.377
2002 Fernández-Galaz MC, Diano S, Horvath TL, Garcia-Segura LM. Leptin uptake by serotonergic neurones of the dorsal raphe. Journal of Neuroendocrinology. 14: 429-34. PMID 12047717 DOI: 10.1046/J.1365-2826.2002.00783.X  0.439
2001 Gerhold LM, Horvath TL, Freeman ME. Vasoactive intestinal peptide fibers innervate neuroendocrine dopaminergic neurons. Brain Research. 919: 48-56. PMID 11689162 DOI: 10.1016/S0006-8993(01)02993-6  0.418
2001 Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective. Endocrinology. 142: 4163-9. PMID 11564668 DOI: 10.1210/Endo.142.10.8490  0.351
2001 Cowley MA, Smart JL, Rubinstein M, Cerdán MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature. 411: 480-4. PMID 11373681 DOI: 10.1038/35078085  0.486
2001 Zsarnovszky A, Horvath TL, Garcia-Segura LM, Horvath B, Naftolin F. Oestrogen-induced changes in the synaptology of the monkey (Cercopithecus aethiops) arcuate nucleus during gonadotropin feedback. Journal of Neuroendocrinology. 13: 22-8. PMID 11123512 DOI: 10.1046/j.1365-2826.2001.00602.x  0.368
2000 Leranth C, Roth RH, Elsworth JD, Naftolin F, Horvath TL, Redmond DE. Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8604-9. PMID 11102464 DOI: 10.1523/Jneurosci.20-23-08604.2000  0.357
2000 Diano S, Urbanski HF, Horvath B, Bechmann I, Kagiya A, Nemeth G, Naftolin F, Warden CH, Horvath TL. Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary. Endocrinology. 141: 4226-38. PMID 11089557 DOI: 10.1210/Endo.141.11.7740  0.373
2000 Dube MG, Horvath TL, Kalra PS, Kalra SP. Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats. Peptides. 21: 1557-60. PMID 11068104 DOI: 10.1016/S0196-9781(00)00311-9  0.404
2000 Zsarnovszky A, Horvath TL, Naftolin F, Leranth C. AMPA receptors colocalize with neuropeptide-Y- and galanin-containing, but not with dopamine, neurons of the female rat arcuate nucleus: a semiquantitative immunohistochemical colocalization study. Experimental Brain Research. 133: 532-7. PMID 10985687 DOI: 10.1007/S002210000425  0.439
2000 Zsarnovszky A, Scalise TJ, Horvath TL, Naftolin F. Estrogen effects on tyrosine hydroxylase-immunoreactive cells in the ventral mesencephalon of the female rat: further evidence for the two cell hypothesis of dopamine function. Brain Research. 868: 363-6. PMID 10854590 DOI: 10.1016/S0006-8993(00)02323-4  0.346
2000 Jain MR, Horvath TL, Kalra PS, Kalra SP. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regulatory Peptides. 87: 19-24. PMID 10710284 DOI: 10.1016/S0167-0115(99)00102-0  0.32
1999 Horvath TL, Warden CH, Hajos M, Lombardi A, Goglia F, Diano S. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10417-27. PMID 10575039 DOI: 10.1523/Jneurosci.19-23-10417.1999  0.425
1999 Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS, van Den Pol AN. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. The Journal of Comparative Neurology. 415: 145-59. PMID 10545156 DOI: 10.1002/(Sici)1096-9861(19991213)415:2<145::Aid-Cne1>3.0.Co;2-2  0.359
1999 Leranth C, Shanabrough M, Horvath TL. Estrogen receptor-alpha in the raphe serotonergic and supramammillary area calretinin-containing neurons of the female rat. Experimental Brain Research. 128: 417-20. PMID 10501815 DOI: 10.1007/S002210050863  0.359
1999 Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia-Segura LM, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Journal of Neurobiology. 40: 484-96. PMID 10453051 DOI: 10.1002/(SICI)1097-4695(19990915)40:4<484::AID-NEU6>3.0.CO;2-C  0.357
1999 Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocrine Reviews. 20: 68-100. PMID 10047974 DOI: 10.1210/Edrv.20.1.0357  0.39
1999 Pu S, Jain MR, Horvath TL, Diano S, Kalra PS, Kalra SP. Interactions between neuropeptide Y and gamma-aminobutyric acid in stimulation of feeding: a morphological and pharmacological analysis. Endocrinology. 140: 933-40. PMID 9927326 DOI: 10.1210/Endo.140.2.6495  0.322
1999 Horvath TL, Diano S, van den Pol AN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1072-87. PMID 9920670 DOI: 10.1523/Jneurosci.19-03-01072.1999  0.463
1998 Kalra SP, Horvath TL. Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite. Annals of the New York Academy of Sciences. 863: 236-40. PMID 9928174 DOI: 10.1111/j.1749-6632.1998.tb10698.x  0.434
1998 Diano S, Kalra SP, Sakamoto H, Horvath TL. Leptin receptors in estrogen receptor-containing neurons of the female rat hypothalamus. Brain Research. 812: 256-9. PMID 9813356 DOI: 10.1016/S0006-8993(98)00936-6  0.402
1998 Diano S, Naftolin F, Goglia F, Horvath TL. Segregation of the intra- and extrahypothalamic neuropeptide Y and catecholaminergic inputs on paraventricular neurons, including those producing thyrotropin-releasing hormone. Regulatory Peptides. 75: 117-26. PMID 9802401 DOI: 10.1016/S0167-0115(98)00060-3  0.396
1998 Diano S, Naftolin F, Goglia F, Csernus V, Horvath TL. Monosynaptic pathway between the arcuate nucleus expressing glial type II iodothyronine 5'-deiodinase mRNA and the median eminence-projective TRH cells of the rat paraventricular nucleus. Journal of Neuroendocrinology. 10: 731-42. PMID 9792325 DOI: 10.1046/J.1365-2826.1998.00204.X  0.325
1998 Diano S, Kalra SP, Horvath TL. Leptin receptor immunoreactivity is associated with the Golgi apparatus of hypothalamic neurons and glial cells. Journal of Neuroendocrinology. 10: 647-50. PMID 9744481 DOI: 10.1046/j.1365-2826.1998.00261.x  0.452
1998 Diano S, Naftolin F, Horvath TL. Kainate glutamate receptors (GluR5-7) in the rat arcuate nucleus: relationship to tanycytes, astrocytes, neurons and gonadal steroid receptors. Journal of Neuroendocrinology. 10: 239-47. PMID 9630393 DOI: 10.1046/J.1365-2826.1998.00195.X  0.332
1998 Horvath TL, Cela V, van der Beek EM. Gender-specific apposition between vasoactive intestinal peptide-containing axons and gonadotrophin-releasing hormone-producing neurons in the rat. Brain Research. 795: 277-81. PMID 9622650 DOI: 10.1016/S0006-8993(98)00208-X  0.367
1998 Horvath TL. An alternate pathway for visual signal integration into the hypothalamo-pituitary axis: retinorecipient intergeniculate neurons project to various regions of the hypothalamus and innervate neuroendocrine cells including those producing dopamine. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1546-58. PMID 9454860 DOI: 10.1523/Jneurosci.18-04-01546.1998  0.392
1997 Horvath TL, Roa-Pena L, Jakab RL, Simpson ER, Naftolin F. Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex. The Journal of Steroid Biochemistry and Molecular Biology. 61: 349-57. PMID 9365210 DOI: 10.1016/S0960-0760(96)00252-X  0.337
1997 Kalra SP, Horvath T, Naftolin F, Xu B, Pu S, Kalra PS. The interactive language of the hypothalamus for the gonadotropin releasing hormone (GNRH) system. Journal of Neuroendocrinology. 9: 569-76. PMID 9283045 DOI: 10.1046/J.1365-2826.1997.00619.X  0.317
1997 Van der Beek EM, Horvath TL, Wiegant VM, Van den Hurk R, Buijs RM. Evidence for a direct neuronal pathway from the suprachiasmatic nucleus to the gonadotropin-releasing hormone system: combined tracing and light and electron microscopic immunocytochemical studies. The Journal of Comparative Neurology. 384: 569-79. PMID 9259490 DOI: 10.1002/(SICI)1096-9861(19970811)384:4<569::AID-CNE6>3.0.CO;2-0  0.381
1997 Horvath TL, Bechmann I, Naftolin F, Kalra SP, Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Research. 756: 283-6. PMID 9187344 DOI: 10.1016/S0006-8993(97)00184-4  0.4
1997 Horvath TL, Garcia-Segura LM, Naftolin F. Control of gonadotropin feedback: the possible role of estrogen-induced hypothalamic synaptic plasticity. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology. 11: 139-43. PMID 9174856 DOI: 10.3109/09513599709152525  0.314
1997 Pu S, Horvath TL, Diano S, Naftolin F, Kalra PS, Kalra SP. Evidence showing that beta-endorphin regulates cyclic guanosine 3',5'-monophosphate (cGMP) efflux: anatomical and functional support for an interaction between opiates and nitric oxide. Endocrinology. 138: 1537-43. PMID 9075713 DOI: 10.1210/Endo.138.4.5086  0.371
1997 Horvath TL. Suprachiasmatic efferents avoid phenestrated capillaries but innervate neuroendocrine cells, including those producing dopamine. Endocrinology. 138: 1312-20. PMID 9048641 DOI: 10.1210/endo.138.3.4976  0.303
1997 Diano S, Naftolin F, Horvath TL. Gonadal steroids target AMPA glutamate receptor-containing neurons in the rat hypothalamus, septum and amygdala: a morphological and biochemical study. Endocrinology. 138: 778-89. PMID 9003015 DOI: 10.1210/Endo.138.2.4937  0.32
1996 Naftolin F, Horvath TL, Jakab RL, Leranth C, Harada N, Balthazart J. Aromatase immunoreactivity in axon terminals of the vertebrate brain. An immunocytochemical study on quail, rat, monkey and human tissues. Neuroendocrinology. 63: 149-55. PMID 9053779 DOI: 10.1159/000126951  0.325
1996 Naftolin F, Mor G, Horvath TL, Luquin S, Fajer AB, Kohen F, Garcia-Segura LM. Synaptic remodeling in the arcuate nucleus during the estrous cycle is induced by estrogen and precedes the preovulatory gonadotropin surge. Endocrinology. 137: 5576-80. PMID 8940386 DOI: 10.1210/endo.137.12.8940386  0.324
1996 Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP. Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology. 137: 3069-78. PMID 8770933 DOI: 10.1210/endo.137.7.8770933  0.365
1996 Naftolin F, Leranth C, Horvath TL, Garcia-Segura LM. Potential neuronal mechanisms of estrogen actions in synaptogenesis and synaptic plasticity. Cellular and Molecular Neurobiology. 16: 213-23. PMID 8743970 DOI: 10.1007/Bf02088177  0.378
1995 Horvath TL, Kalra SP, Naftolin F, Leranth C. Morphological evidence for a galanin-opiate interaction in the rat mediobasal hypothalamus. Journal of Neuroendocrinology. 7: 579-88. PMID 8704731 DOI: 10.1111/J.1365-2826.1995.Tb00795.X  0.324
1995 Herbison AE, Horvath TL, Naftolin F, Leranth C. Distribution of estrogen receptor-immunoreactive cells in monkey hypothalamus: relationship to neurones containing luteinizing hormone-releasing hormone and tyrosine hydroxylase. Neuroendocrinology. 61: 1-10. PMID 7731492 DOI: 10.1159/000126810  0.403
1995 Horvath TL, Leranth C, Kalra SP, Naftolin F. Galanin neurons exhibit estrogen receptor immunoreactivity in the female rat mediobasal hypothalamus. Brain Research. 675: 321-4. PMID 7540929 DOI: 10.1016/0006-8993(94)01374-Q  0.393
1994 Leranth C, Naftolin F, Shanabrough M, Horvath TL. 25 - Electron Microscopic Double and Triple Labeling Immunocytochemistry in Elucidation of Synaptological Interactions between Ovarian Steroid-Sensitive Neurons and Circuits Methods in Neurosciences. 22: 403-434. DOI: 10.1016/B978-0-12-185292-4.50031-0  0.336
1993 Jakab RL, Horvath TL, Leranth C, Harada N, Naftolin F. Aromatase immunoreactivity in the rat brain: gonadectomy-sensitive hypothalamic neurons and an unresponsive "limbic ring" of the lateral septum-bed nucleus-amygdala complex. The Journal of Steroid Biochemistry and Molecular Biology. 44: 481-98. PMID 8476763 DOI: 10.1016/0960-0760(93)90253-S  0.424
1993 Horvath TL, Shanabrough M, Naftolin F, Leranth C. Neuropeptide-Y innervation of estrogen-induced progesterone receptor-containing dopamine cells in the monkey hypothalamus: a triple labeling light and electron microscopic study. Endocrinology. 133: 405-14. PMID 8100520 DOI: 10.1210/endo.133.1.8100520  0.379
1993 Horvath TL, Naftolin F, Leranth C. Luteinizing hormone-releasing hormone and gamma-aminobutyric acid neurons in the medial preoptic area are synaptic targets of dopamine axons originating in anterior periventricular areas. Journal of Neuroendocrinology. 5: 71-9. PMID 8097941 DOI: 10.1111/J.1365-2826.1993.Tb00365.X  0.329
1992 Horvath TL, Leranth C, Naftolin F. Presence of calbindin and lack of parvalbumin in progesterone receptor-containing neurons of the monkey mediobasal hypothalamus. Neuroscience. 50: 309-14. PMID 1436493 DOI: 10.1016/0306-4522(92)90425-2  0.405
1992 Horvath TL, Naftolin F, Kalra SP, Leranth C. Neuropeptide-Y innervation of beta-endorphin-containing cells in the rat mediobasal hypothalamus: a light and electron microscopic double immunostaining analysis. Endocrinology. 131: 2461-7. PMID 1425443 DOI: 10.1210/endo.131.5.1425443  0.323
1992 Horvath TL, Naftolin F, Leranth C. Beta-endorphin innervation of dopamine neurons in the rat hypothalamus: a light and electron microscopic double immunostaining study. Endocrinology. 131: 1547-55. PMID 1354605 DOI: 10.1210/endo.131.3.1354605  0.355
1992 Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic beta-endorphin cells projecting to the medial preoptic area. Neuroscience. 51: 391-9. PMID 1281529 DOI: 10.1016/0306-4522(92)90323-T  0.398
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