James Shorter - Publications

Neuroscience University of Pennsylvania, Philadelphia, PA, United States 
Neuroscience Biology

137 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rhine K, Makurath MA, Liu J, Skanchy S, Lopez C, Catalan KF, Ma Y, Fare CM, Shorter J, Ha T, Chemla YR, Myong S. ALS/FTLD-Linked Mutations in FUS Glycine Residues Cause Accelerated Gelation and Reduced Interactions with Wild-Type FUS. Molecular Cell. 80: 1139. PMID 33338404 DOI: 10.1016/j.molcel.2020.11.031  1
2020 March ZM, Sweeney K, Kim H, Yan X, Castellano LM, Jackrel ME, Lin J, Chuang E, Gomes E, Willicott CW, Michalska K, Jedrzejczak RP, Joachimiak A, Caldwell KA, Caldwell GA, ... ... Shorter J, et al. Therapeutic genetic variation revealed in diverse Hsp104 homologs. Elife. 9. PMID 33319748 DOI: 10.7554/eLife.57457  1
2020 Zhu G, Harischandra DS, Ghaisas S, Zhang P, Prall W, Huang L, Maghames C, Guo L, Luna E, Mack KL, Torrente MP, Luk KC, Shorter J, Yang X. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Cell Reports. 33: 108418. PMID 33264628 DOI: 10.1016/j.celrep.2020.108418  1
2020 Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, ... ... Shorter J, et al. poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12. PMID 32878979 DOI: 10.1126/scitranslmed.abb3774  0.92
2020 Darling AL, Shorter J. Atomic Structures of Amyloid-β Oligomers Illuminate a Neurotoxic Mechanism. Trends in Neurosciences. PMID 32792144 DOI: 10.1016/j.tins.2020.07.006  0.88
2020 Odeh HM, Shorter J. Arginine-rich dipeptide-repeat proteins as phase disruptors in C9-ALS/FTD. Emerging Topics in Life Sciences. PMID 32639008 DOI: 10.1042/ETLS20190167  0.92
2020 Cupo RR, Shorter J. Skd3 (human ) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. Elife. 9. PMID 32573439 DOI: 10.7554/eLife.55279  0.56
2020 Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR. Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nature Structural & Molecular Biology. PMID 32313240 DOI: 10.1038/s41594-020-0409-5  0.68
2020 Gitler AD, Shorter J, Ha T, Myong S. Just Took a DNA Test, Turns Out 100% Not That Phase. Molecular Cell. 78: 193-194. PMID 32302539 DOI: 10.1016/j.molcel.2020.03.029  1
2020 Ye X, Lin J, Mayne L, Shorter J, Englander SW. Structural and kinetic basis for the regulation and potentiation of Hsp104 function. Proceedings of the National Academy of Sciences of the United States of America. PMID 32277033 DOI: 10.1073/pnas.1921968117  1
2020 Odeh HM, Shorter J. The Sense of Targeting Nonsense-Mediated Decay in C9-ALS/FTD. Neuron. 106: 6-9. PMID 32272067 DOI: 10.1016/j.neuron.2020.03.017  0.92
2020 Wobst HJ, Mack KL, Brown DG, Brandon NJ, Shorter J. The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future. Medicinal Research Reviews. PMID 32043626 DOI: 10.1002/med.21661  0.96
2019 Sweeny EA, Tariq A, Gurpinar E, Go MS, Sochor MA, Kan ZY, Mayne L, Englander SW, Shorter J. Structural and mechanistic insights into Hsp104 function revealed by synchrotron x-ray footprinting. The Journal of Biological Chemistry. PMID 31882541 DOI: 10.1074/jbc.RA119.011577  1
2019 Jones RD, Enam C, Ibarra R, Borror HR, Mostoller KE, Fredrickson EK, Lin J, Chuang E, March Z, Shorter J, Ravid T, Kleiger G, Gardner RG. The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate. Molecular Biology of the Cell. mbcE18020121. PMID 31825716 DOI: 10.1091/mbc.E18-02-0121  1
2019 Portz B, Shorter J. Switching Condensates: The CTD Code Goes Liquid. Trends in Biochemical Sciences. PMID 31734037 DOI: 10.1016/j.tibs.2019.10.009  0.92
2019 Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Correction: Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. 294: 17707. PMID 31732685 DOI: 10.1074/jbc.AAC119.011523  1
2019 Niaki AG, Sarkar J, Cai X, Rhine K, Vidaurre V, Guy B, Hurst M, Lee JC, Koh HR, Guo L, Fare CM, Shorter J, Myong S. Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations. Molecular Cell. PMID 31630970 DOI: 10.1016/j.molcel.2019.09.022  1
2019 Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, ... ... Shorter J, et al. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. PMID 31587919 DOI: 10.1016/j.neuron.2019.09.003  0.92
2019 Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, ... ... Shorter J, et al. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Reports. 28: 2080-2095.e6. PMID 31433984 DOI: 10.1016/j.celrep.2019.07.069  1
2019 Ryan JJ, Sprunger ML, Holthaus K, Shorter J, Jackrel ME. Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of Biological Chemistry. PMID 31171724 DOI: 10.1074/jbc.RA119.009494  1
2019 Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nature Communications. 10: 2393. PMID 31160557 DOI: 10.1038/s41467-019-10150-y  1
2019 Durie CL, Lin J, Scull NW, Mack KL, Jackrel ME, Sweeny EA, Castellano LM, Shorter J, Lucius AL. Hsp104 and Potentiated Variants Can Operate as Distinct Nonprocessive Translocases. Biophysical Journal. PMID 31027887 DOI: 10.1016/j.bpj.2019.03.035  1
2019 March ZM, Mack KL, Shorter J. AAA+ Protein-Based Technologies to Counter Neurodegenerative Disease. Biophysical Journal. PMID 30952364 DOI: 10.1016/j.bpj.2019.03.007  1
2019 Ye X, Lin J, Mayne L, Shorter J, Englander SW. Hydrogen exchange reveals Hsp104 architecture, structural dynamics, and energetics in physiological solution. Proceedings of the National Academy of Sciences of the United States of America. PMID 30918129 DOI: 10.1073/pnas.1816184116  1
2019 Gasset-Rosa F, Lu S, Yu H, Chen C, Melamed Z, Guo L, Shorter J, Da Cruz S, Cleveland DW. Cytoplasmic TDP-43 De-mixing Independent of Stress Granules Drives Inhibition of Nuclear Import, Loss of Nuclear TDP-43, and Cell Death. Neuron. PMID 30853299 DOI: 10.1016/j.neuron.2019.02.038  1
2019 Mann JR, Gleixner AM, Mauna JC, Gomes E, DeChellis-Marks MR, Needham PG, Copley KE, Hurtle B, Portz B, Pyles NJ, Guo L, Calder CB, Wills ZP, Pandey UB, Kofler JK, ... ... Shorter J, et al. RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43. Neuron. PMID 30826182 DOI: 10.1016/j.neuron.2019.01.048  1
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, ... ... Shorter J, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/science.aav2606  1
2019 Shorter J, Southworth DR. Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase. Cold Spring Harbor Perspectives in Biology. PMID 30745294 DOI: 10.1101/cshperspect.a034033  0.56
2019 Guo L, Fare CM, Shorter J. Therapeutic Dissolution of Aberrant Phases by Nuclear-Import Receptors. Trends in Cell Biology. PMID 30660504 DOI: 10.1016/j.tcb.2018.12.004  1
2018 Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A. Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure (London, England : 1993). PMID 30595457 DOI: 10.1016/j.str.2018.11.001  1
2018 McGurk L, Gomes E, Guo L, Shorter J, Bonini N. Poly(ADP-ribose) engages the TDP-43 nuclear-localization sequence to regulate granulo-filamentous aggregation. Biochemistry. PMID 30540446 DOI: 10.1021/acs.biochem.8b00910  1
2018 Portz B, Shorter J. 3' UTRs in the Eye of the TIGER. Developmental Cell. 47: 544-546. PMID 30513300 DOI: 10.1016/j.devcel.2018.11.022  0.92
2018 Vogler TO, Wheeler JR, Nguyen ED, Hughes MP, Britson KA, Lester E, Rao B, Betta ND, Whitney ON, Ewachiw TE, Gomes E, Shorter J, Lloyd TE, Eisenberg DS, Taylor JP, et al. TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle. Nature. 563: 508-513. PMID 30464263 DOI: 10.1038/s41586-018-0665-2  0.52
2018 McGurk L, Gomes E, Guo L, Mojsilovic-Petrovic J, Tran V, Kalb RG, Shorter J, Bonini NM. Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization. Molecular Cell. PMID 30100264 DOI: 10.1016/j.molcel.2018.07.002  1
2018 Gomes E, Shorter J. The molecular language of membraneless organelles. The Journal of Biological Chemistry. PMID 30045872 DOI: 10.1074/jbc.TM118.001192  0.52
2018 Bogaert E, Boeynaems S, Kato M, Guo L, Caulfield TR, Steyaert J, Scheveneels W, Wilmans N, Haeck W, Hersmus N, Schymkowitz J, Rousseau F, Shorter J, Callaerts P, Robberecht W, et al. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Cell Reports. 24: 529-537.e4. PMID 30021151 DOI: 10.1016/j.celrep.2018.06.070  1
2018 Bart SM, Cohen C, Dye JM, Shorter J, Bates P. Enhancement of Ebola virus infection by seminal amyloid fibrils. Proceedings of the National Academy of Sciences of the United States of America. PMID 29941593 DOI: 10.1073/pnas.1721646115  1
2018 Tariq A, Lin J, Noll MM, Torrente MP, Mack KL, Murillo OH, Jackrel ME, Shorter J. Potentiating Hsp104 activity via phosphomimetic mutations in the middle domain. Fems Yeast Research. 18. PMID 29788207 DOI: 10.1093/femsyr/foy042  1
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, ... ... Shorter J, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/j.cell.2018.03.002  1
2018 Chuang E, Hori AM, Hesketh CD, Shorter J. Amyloid assembly and disassembly. Journal of Cell Science. 131. PMID 29654159 DOI: 10.1242/jcs.189928  1
2018 Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. Protein Phase Separation: A New Phase in Cell Biology. Trends in Cell Biology. PMID 29602697 DOI: 10.1016/j.tcb.2018.02.004  1
2018 Zhang T, Wu YC, Mullane P, Ji YJ, Liu H, He L, Arora A, Hwang HY, Alessi AF, Niaki AG, Periz G, Guo L, Wang H, Elkayam E, Joshua-Tor L, ... ... Shorter J, et al. FUS Regulates Activity of MicroRNA-Mediated Gene Silencing. Molecular Cell. 69: 787-801.e8. PMID 29499134 DOI: 10.1016/j.molcel.2018.02.001  1
2017 Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science (New York, N.Y.). PMID 28619716 DOI: 10.1126/science.aan1052  1
2017 Gitler AD, Dhillon P, Shorter J. Neurodegenerative disease: models, mechanisms, and a new hope. Disease Models & Mechanisms. 10: 499-502. PMID 28468935 DOI: 10.1242/dmm.030205  1
2017 Weaver CL, Duran EC, Mack KL, Lin J, Jackrel ME, Sweeny EA, Shorter J, Lucius AL. Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. PMID 28379007 DOI: 10.1021/acs.biochem.7b00225  1
2017 Yasuda K, Clatterbuck-Soper SF, Jackrel ME, Shorter J, Mili S. FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. The Journal of Cell Biology. PMID 28298410 DOI: 10.1083/jcb.201608022  1
2017 Jackrel ME, Shorter J. Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease. Frontiers in Neuroscience. 11: 99. PMID 28293166 DOI: 10.3389/fnins.2017.00099  1
2016 Guo L, Shorter J. Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies. Cold Spring Harbor Perspectives in Medicine. PMID 27920024 DOI: 10.1101/cshperspect.a024554  1
2016 Shorter J, Gitler AD. Susan Lee Lindquist (1949-2016). Nature. 540: 40. PMID 27905439 DOI: 10.1038/540040a  1
2016 Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nature Structural & Molecular Biology. PMID 27478928 DOI: 10.1038/nsmb.3277  1
2016 Mack KL, Shorter J. Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity. Frontiers in Molecular Biosciences. 3: 8. PMID 27014702 DOI: 10.3389/fmolb.2016.00008  0.96
2016 March ZM, King OD, Shorter J. Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Research. PMID 26996412 DOI: 10.1016/j.brainres.2016.02.037  1
2016 Torrente MP, Chuang E, Noll MM, Jackrel ME, Go MS, Shorter J. Mechanistic Insights Into Hsp104 Potentiation. The Journal of Biological Chemistry. PMID 26747608 DOI: 10.1074/jbc.M115.707976  1
2016 Sweeny EA, Shorter J. Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104. Journal of Molecular Biology. 428: 1870-85. PMID 26608812 DOI: 10.1016/j.jmb.2015.11.016  1
2016 Shorter J. Engineering therapeutic protein disaggregases Molecular Biology of the Cell. 27: 1556-1560. DOI: 10.1091/mbc.E15-10-0693  1
2016 Shorter J. Membraneless organelles: Phasing in and out Nature Chemistry. 8: 528-530. DOI: 10.1038/nchem.2534  1
2016 Sweeny EA, Shorter J. Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104 Journal of Molecular Biology. 428: 1870-1885. DOI: 10.1016/j.jmb.2015.11.016  1
2015 Guo L, Shorter J. It's Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles. Molecular Cell. 60: 189-92. PMID 26474062 DOI: 10.1016/j.molcel.2015.10.006  1
2015 Lindberg I, Shorter J, Wiseman RL, Chiti F, Dickey CA, McLean PJ. Chaperones in Neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13853-9. PMID 26468185 DOI: 10.1523/JNEUROSCI.2600-15.2015  1
2015 Ford AF, Shorter J. Fleeting Amyloid-like Forms of Rim4 Ensure Meiotic Fidelity. Cell. 163: 275-6. PMID 26451477 DOI: 10.1016/j.cell.2015.09.049  1
2015 Jackrel ME, Yee K, Tariq A, Chen AI, Shorter J. Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. Acs Chemical Biology. PMID 26441009 DOI: 10.1021/acschembio.5b00765  1
2015 Castellano LM, Hammond RM, Holmes VM, Weissman D, Shorter J. Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biology Open. 4: 1206-12. PMID 26319581 DOI: 10.1242/bio.010215  1
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Shorter J, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection. Elife. 4. PMID 26284498 DOI: 10.7554/eLife.05397  1
2015 Castellano LM, Bart SM, Holmes VM, Weissman D, Shorter J. Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection. Chemistry & Biology. 22: 1074-86. PMID 26256479 DOI: 10.1016/j.chembiol.2015.07.007  1
2015 Zirafi O, Kim KA, Ständker L, Mohr KB, Sauter D, Heigele A, Kluge SF, Wiercinska E, Chudziak D, Richter R, Moepps B, Gierschik P, Vas V, Geiger H, Lamla M, ... ... Shorter J, et al. Discovery and characterization of an endogenous CXCR4 antagonist. Cell Reports. 11: 737-47. PMID 25921529 DOI: 10.1016/j.celrep.2015.03.061  1
2015 Jackrel ME, Shorter J. Engineering enhanced protein disaggregases for neurodegenerative disease. Prion. 9: 90-109. PMID 25738979 DOI: 10.1080/19336896.2015.1020277  1
2015 Sweeny EA, Jackrel ME, Go MS, Sochor MA, Razzo BM, DeSantis ME, Gupta K, Shorter J. The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Molecular Cell. 57: 836-49. PMID 25620563 DOI: 10.1016/j.molcel.2014.12.021  1
2015 Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, Von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, ... ... Shorter J, et al. A molecular tweezer antagonizes seminal amyloids and HIV infection Elife. 4. DOI: 10.7554/eLife.05397  1
2014 Jackrel ME, Tariq A, Yee K, Weitzman R, Shorter J. Isolating potentiated Hsp104 variants using yeast proteinopathy models. Journal of Visualized Experiments : Jove. e52089. PMID 25407485 DOI: 10.3791/52089  1
2014 Torrente MP, Castellano LM, Shorter J. Suramin inhibits Hsp104 ATPase and disaggregase activity Plos One. 9. PMID 25299406 DOI: 10.1371/journal.pone.0110115  1
2014 Seither KM, McMahon HA, Singh N, Wang H, Cushman-Nick M, Montalvo GL, DeGrado WF, Shorter J. Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly. The Biochemical Journal. 464: 85-98. PMID 25142005 DOI: 10.1042/BJ20131609  1
2014 Jackrel ME, Shorter J. Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins. Disease Models & Mechanisms. 7: 1175-84. PMID 25062688 DOI: 10.1242/dmm.016113  1
2014 Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/j.molcel.2014.04.030  1
2014 Jackrel ME, Shorter J. Reversing deleterious protein aggregation with re-engineered protein disaggregases. Cell Cycle (Georgetown, Tex.). 13: 1379-83. PMID 24694655 DOI: 10.4161/cc.28709  1
2014 Qiu H, Lee S, Shang Y, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Lui H, Carlton CE, Tang AA, Oldham MC, Wang H, Shorter J, Filiano AJ, et al. ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. The Journal of Clinical Investigation. 124: 981-99. PMID 24509083 DOI: 10.1172/JCI72723  1
2014 Jackrel ME, DeSantis ME, Martinez BA, Castellano LM, Stewart RM, Caldwell KA, Caldwell GA, Shorter J. Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events. Cell. 156: 170-82. PMID 24439375 DOI: 10.1016/j.cell.2013.11.047  1
2014 Desantis ME, Sweeny EA, Snead D, Leung EH, Go MS, Gupta K, Wendler P, Shorter J. Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. The Journal of Biological Chemistry. 289: 848-67. PMID 24280225 DOI: 10.1074/jbc.M113.520759  1
2013 Torrente MP, Shorter J. The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins Prion. 7: 457-463. PMID 24401655 DOI: 10.4161/pri.27531  1
2013 Cushman-Nick M, Bonini NM, Shorter J. Hsp104 suppresses polyglutamine-induced degeneration post onset in a drosophila MJD/SCA3 model. Plos Genetics. 9: e1003781. PMID 24039611 DOI: 10.1371/journal.pgen.1003781  1
2013 Coelho M, Dereli A, Haese A, Kühn S, Malinovska L, DeSantis ME, Shorter J, Alberti S, Gross T, Tolić-Nørrelykke IM. Fission yeast does not age under favorable conditions, but does so after stress. Current Biology : Cb. 23: 1844-52. PMID 24035542 DOI: 10.1016/j.cub.2013.07.084  1
2013 Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. The Journal of Cell Biology. 201: 361-72. PMID 23629963 DOI: 10.1083/jcb.201302044  1
2013 Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, ... ... Shorter J, et al. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 495: 467-73. PMID 23455423 DOI: 10.1038/nature11922  1
2012 Castellano LM, Shorter J. The Surprising Role of Amyloid Fibrils in HIV Infection. Biology. 1: 58-80. PMID 24832047 DOI: 10.3390/biology1010058  1
2012 Desantis ME, Shorter J. Hsp104 drives "protein-only" positive selection of sup35 prion strains encoding strong [PSI+] Chemistry and Biology. 19: 1400-1410. PMID 23177195 DOI: 10.1016/j.chembiol.2012.09.013  1
2012 DeSantis ME, Leung EH, Sweeny EA, Jackrel ME, Cushman-Nick M, Neuhaus-Follini A, Vashist S, Sochor MA, Knight MN, Shorter J. Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. Cell. 151: 778-93. PMID 23141537 DOI: 10.1016/j.cell.2012.09.038  1
2012 Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics. 44: 1302-9. PMID 23104007 DOI: 10.1038/ng.2434  1
2012 Ugras SE, Shorter J. RNA-Binding Proteins in Amyotrophic Lateral Sclerosis and Neurodegeneration. Neurology Research International. 2012: 432780. PMID 22919483 DOI: 10.1155/2012/432780  1
2012 Duennwald ML, Echeverria A, Shorter J. Small heat shock proteins potentiate amyloid dissolution by protein disaggregases from yeast and humans. Plos Biology. 10: e1001346. PMID 22723742 DOI: 10.1371/journal.pbio.1001346  1
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Shorter J, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/hmg/dds116  1
2012 King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Research. 1462: 61-80. PMID 22445064 DOI: 10.1016/j.brainres.2012.01.016  1
2012 DeSantis ME, Shorter J. The elusive middle domain of Hsp104 and ClpB: Location and function Biochimica Et Biophysica Acta - Molecular Cell Research. 1823: 29-39. PMID 21843558 DOI: 10.1016/j.bbamcr.2011.07.014  1
2012 Castellano LM, Shorter J. The surprising role of amyloid fibrils in HIV infection Biology. 1: 58-80. DOI: 10.3390/biology1010058  1
2012 Ugras SE, Shorter J. RNA-binding proteins in amyotrophic lateral sclerosis and neurodegeneration Neurology Research International. 2012. DOI: 10.1155/2012/432780  1
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/pnas.1109434108  1
2011 Sweeny EA, DeSantis ME, Shorter J. Purification of hsp104, a protein disaggregase Journal of Visualized Experiments : Jove. PMID 21989490 DOI: 10.3791/3190  1
2011 Gitler AD, Shorter J. RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion. 5: 179-87. PMID 21847013 DOI: 10.4161/pri.5.3.17230  1
2011 Jackrel ME, Shorter J. Shock and awe: unleashing the heat shock response to treat Huntington disease. The Journal of Clinical Investigation. 121: 2972-5. PMID 21785212 DOI: 10.1172/JCI59190  1
2011 Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, Shorter J, Gitler AD. Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. Plos Biology. 9: e1000614. PMID 21541367 DOI: 10.1371/journal.pbio.1000614  1
2011 Shorter J. The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system Plos One. 6. DOI: 10.1371/journal.pone.0026319  1
2011 Shorter J. Amyloid Remodeling by Hsp104 Protein Chaperones and Protection From Neurodegenerative Diseases. 235-259. DOI: 10.1002/9781118063903.ch7  1
2010 Duennwald ML, Shorter J. Countering amyloid polymorphism and drug resistance with minimal drug cocktails. Prion. 4: 244-51. PMID 20935457 DOI: 10.4161/pri.4.4.13597  1
2010 Shorter J. Emergence and natural selection of drug-resistant prions Molecular Biosystems. 6: 1115-1130. PMID 20422111 DOI: 10.1039/c004550k  1
2010 Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. Journal of Cell Science. 123: 1191-201. PMID 20356930 DOI: 10.1242/jcs.051672  1
2010 Vashist S, Cushman M, Shorter J. Applying Hsp104 to protein-misfolding disorders Biochemistry and Cell Biology. 88: 1-13. PMID 20130674 DOI: 10.1139/O09-121  1
2009 Roberts BE, Duennwald ML, Wang H, Chung C, Lopreiato NP, Sweeny EA, Knight MN, Shorter J. A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nature Chemical Biology. 5: 936-46. PMID 19915541 DOI: 10.1038/nchembio.246  1
2009 Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-terminal domains elicit formation of functional Pmel17 amyloid fibrils. The Journal of Biological Chemistry. 284: 35543-55. PMID 19840945 DOI: 10.1074/jbc.M109.047449  1
2009 Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. The Journal of Biological Chemistry. 284: 20329-39. PMID 19465477 DOI: 10.1074/jbc.M109.010264  1
2009 Wendler P, Shorter J, Snead D, Plisson C, Clare DK, Lindquist S, Saibil HR. Motor Mechanism for Protein Threading through Hsp104 Molecular Cell. 34: 81-92. PMID 19362537 DOI: 10.1016/j.molcel.2009.02.026  1
2008 Sweeny EA, Shorter J. Prion proteostasis: Hsp104 meets its supporting cast Prion. 2: 135-140. PMID 19242125 DOI: 10.4161/pri.2.4.7952  1
2008 Skinner JJ, Wood S, Shorter J, Englander SW, Black BE. The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching. The Journal of Cell Biology. 183: 761-8. PMID 19029339 DOI: 10.1083/jcb.200808122  1
2008 Shorter J, Lindquist S. Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions Embo Journal. 27: 2712-2724. PMID 18833196 DOI: 10.1038/emboj.2008.194  1
2008 Maday S, Anderson E, Chang HC, Shorter J, Satoh A, Sfakianos J, Fölsch H, Anderson JM, Walther Z, Mellman I. A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. Traffic (Copenhagen, Denmark). 9: 1915-24. PMID 18764819 DOI: 10.1111/j.1600-0854.2008.00805.x  1
2008 Lo Bianco C, Shorter J, Régulier E, Lashuel H, Iwatsubo T, Lindquist S, Aebischer P. Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. The Journal of Clinical Investigation. 118: 3087-97. PMID 18704197 DOI: 10.1172/JCI35781  1
2008 Roberts BE, Shorter J. Escaping amyloid fate Nature Structural and Molecular Biology. 15: 544-546. PMID 18523464 DOI: 10.1038/nsmb0608-544  1
2008 Wang H, Duennwald ML, Roberts BE, Rozeboom LM, Zhang YL, Steele AD, Krishnan R, Su LJ, Griffin D, Mukhopadhyay S, Hennessy EJ, Weigele P, Blanchard BJ, King J, Deniz AA, ... ... Shorter J, et al. Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proceedings of the National Academy of Sciences of the United States of America. 105: 7159-64. PMID 18480256 DOI: 10.1073/pnas.0801934105  1
2008 Sadlish H, Rampelt H, Shorter J, Wegrzyn RD, Andréasson C, Lindquist S, Bukau B. Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. Plos One. 3: e1763. PMID 18335038 DOI: 10.1371/journal.pone.0001763  1
2008 Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 145-50. PMID 18162536 DOI: 10.1073/pnas.0710685105  1
2007 Wendler P, Shorter J, Plisson C, Cashikar AG, Lindquist S, Saibil HR. Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104 Cell. 131: 1366-1377. PMID 18160044 DOI: 10.1016/j.cell.2007.10.047  1
2007 Shorter J. Hsp104: A weapon to combat diverse neurodegenerative disorders Neurosignals. 16: 63-74. PMID 18097161 DOI: 10.1159/000109760  1
2007 Gitler AD, Shorter J. Prime time for alpha-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2433-4. PMID 17344380 DOI: 10.1523/JNEUROSCI.0094-07.2007  1
2007 Doyle SM, Shorter J, Zolkiewski M, Hoskins JR, Lindquist S, Wickner S. Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity Nature Structural and Molecular Biology. 14: 114-122. PMID 17259993 DOI: 10.1038/nsmb1198  1
2006 Shorter J, Lindquist S. Destruction or Potentiation of Different Prions Catalyzed by Similar Hsp104 Remodeling Activities Molecular Cell. 23: 425-438. PMID 16885031 DOI: 10.1016/j.molcel.2006.05.042  1
2005 Shorter J, Lindquist S. Prions as adaptive conduits of memory and inheritance Nature Reviews Genetics. 6: 435-450. PMID 15931169 DOI: 10.1038/nrg1616  1
2005 Beard M, Satoh A, Shorter J, Warren G. A cryptic Rab1-binding site in the p115 tethering protein. The Journal of Biological Chemistry. 280: 25840-8. PMID 15878873 DOI: 10.1074/jbc.M503925200  1
2005 Shorter J, Lindquist S. Navigating the CIpB channel to solution Nature Structural and Molecular Biology. 12: 4-6. PMID 15689967 DOI: 10.1038/nsmb0105-4  1
2004 Shorter J, Lindquist S. Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers Science. 304: 1793-1797. PMID 15155912 DOI: 10.1126/science.1098007  1
2003 Wang Y, Seemann J, Pypaert M, Shorter J, Warren G. A direct role for GRASP65 as a mitotically regulated Golgi stacking factor. The Embo Journal. 22: 3279-90. PMID 12839990 DOI: 10.1093/emboj/cdg317  1
2002 Shorter J, Warren G. Golgi architecture and inheritance Annual Review of Cell and Developmental Biology. 18: 379-420. PMID 12142281 DOI: 10.1146/annurev.cellbio.18.030602.133733  1
2002 Muller JM, Shorter J, Newman R, Deinhardt K, Sagiv Y, Elazar Z, Warren G, Shima DT. Sequential SNARE disassembly and GATE-16-GOS-28 complex assembly mediated by distinct NSF activities drives Golgi membrane fusion. The Journal of Cell Biology. 157: 1161-73. PMID 12070132 DOI: 10.1083/jcb.200202082  1
2002 Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. The Journal of Cell Biology. 157: 45-62. PMID 11927603 DOI: 10.1083/jcb.200112127  1
2000 Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G. Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments. The Journal of Cell Biology. 150: 475-88. PMID 10931861 DOI: 10.1083/jcb.150.3.475  1
2000 Meyer HH, Shorter JG, Seemann J, Pappin D, Warren G. A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. The Embo Journal. 19: 2181-92. PMID 10811609 DOI: 10.1093/emboj/19.10.2181  1
2000 Barr FA, Shorter J. Membrane traffic: Do cones mark sites of fission? Current Biology. 10. PMID 10704406 DOI: 10.1016/S0960-9822(00)00326-2  1
2000 Lesa GM, Seemann J, Shorter J, Vandekerckhove J, Warren G. The amino-terminal domain of the golgi protein giantin interacts directly with the vesicle-tethering protein p115. The Journal of Biological Chemistry. 275: 2831-6. PMID 10644749  1
1999 Müller JM, Rabouille C, Newman R, Shorter J, Freemont P, Schiavo G, Warren G, Shima DT. An NSF function distinct from ATPase-dependent SNARE disassembly is essential for Golgi membrane fusion. Nature Cell Biology. 1: 335-40. PMID 10559959 DOI: 10.1038/14025  1
1999 Shorter J, Watson R, Giannakou ME, Clarke M, Warren G, Barr FA. GRASP55, a second mammalian GRASP protein involved in the stacking of Golgi cisternae in a cell-free system. The Embo Journal. 18: 4949-60. PMID 10487747 DOI: 10.1093/emboj/18.18.4949  1
1999 Shorter J, Warren G. A role for the vesicle tethering protein, p115, in the post-mitotic stacking of reassembling Golgi cisternae in a cell-free system Journal of Cell Biology. 146: 57-70. PMID 10402460 DOI: 10.1083/jcb.146.1.57  1
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