David H. Gutmann - Publications

Biology and Biomedical Sciences (Neurosciences) Washington University, Saint Louis, St. Louis, MO 
Cell Biology, Oncology, Neuroscience Biology

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Year Citation  Score
2021 de Andrade Costa A, Chatterjee J, Cobb O, Cordell E, Chao A, Schaeffer S, Goldstein A, Dahiya S, Gutmann DH. Immune deconvolution and temporal mapping identifies stromal targets and developmental intervals for abrogating murine low-grade optic glioma formation. Neuro-Oncology Advances. 4: vdab194. PMID 35187488 DOI: 10.1093/noajnl/vdab194  0.32
2021 Fisher MJ, Jones DTW, Li Y, Guo X, Sonawane PS, Waanders AJ, Phillips JJ, Weiss WA, Resnick AC, Gosline S, Banerjee J, Guinney J, Gnekow A, Kandels D, Foreman NK, ... ... Gutmann DH, et al. Integrated molecular and clinical analysis of low-grade gliomas in children with neurofibromatosis type 1 (NF1). Acta Neuropathologica. PMID 33585982 DOI: 10.1007/s00401-021-02276-5  0.348
2020 Mo J, Anastasaki C, Chen Z, Shipman T, Papke JB, Yin KY, Gutmann DH, Le LQ. Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins. The Journal of Clinical Investigation. PMID 33108355 DOI: 10.1172/JCI139807  0.348
2020 Lauko A, Mu Z, Gutmann DH, Naik UP, Lathia JD. Junctional adhesion molecules in cancer: a paradigm for the diverse functions of cell-cell interactions in tumor progression. Cancer Research. PMID 32816855 DOI: 10.1158/0008-5472.Can-20-1829  0.351
2020 Elmadany N, Logiacco F, Buonfiglioli A, Haage V, Wright-Jin EC, Schattenberg A, Papawassiliou R, Kettenmann H, Semtner M, Gutmann DH. Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects. Neurobiology of Disease. 105030. PMID 32736084 DOI: 10.1016/J.Nbd.2020.105030  0.348
2020 Nix JS, Yuan M, Imada EL, Ames H, Marchionni L, Gutmann DH, Rodriguez FJ. Global microRNA profiling identified miR-10b-5p as a regulator of neurofibromatosis 1 (NF1)-glioma migration. Neuropathology and Applied Neurobiology. PMID 32603552 DOI: 10.1111/Nan.12641  0.351
2020 Guo X, Pan Y, Xiong M, Sanapala S, Anastasaki C, Cobb O, Dahiya S, Gutmann DH. Midkine activation of CD8 T cells establishes a neuron-immune-cancer axis responsible for low-grade glioma growth. Nature Communications. 11: 2177. PMID 32358581 DOI: 10.1038/S41467-020-15770-3  0.39
2020 Mahdi J, Goyal MS, Griffith J, Morris SM, Gutmann DH. Nonoptic pathway tumors in children with neurofibromatosis type 1. Neurology. PMID 32300062 DOI: 10.1212/Wnl.0000000000009458  0.384
2020 Anastasaki C, Wegscheid ML, Hartigan K, Papke JB, Kopp ND, Chen J, Cobb O, Dougherty JD, Gutmann DH. Human iPSC-Derived Neurons and Cerebral Organoids Establish Differential Effects of Germline NF1 Gene Mutations. Stem Cell Reports. PMID 32243842 DOI: 10.1016/J.Stemcr.2020.03.007  0.37
2020 Ullrich NJ, Prabhu SP, Reddy AT, Fisher MJ, Packer R, Goldman S, Robison NJ, Gutmann DH, Viskochil DH, Allen JC, Korf B, Cantor A, Cutter G, Thomas C, Perentesis JP, et al. A Phase II Study of Continuous Oral mTOR Inhibitor Everolimus for Recurrent, Radiographic-Progressive Neurofibromatosis Type 1-Associated Pediatric Low-Grade Glioma: A Neurofibromatosis Clinical Trials Consortium Study. Neuro-Oncology. PMID 32236425 DOI: 10.1093/Neuonc/Noaa071  0.347
2020 Packer RJ, Iavarone A, Jones DTW, Blakeley JO, Bouffet E, Fisher MJ, Hwang E, Hawkins C, Kilburn L, MacDonald T, Pfister SM, Rood B, Rodriguez FJ, Tabori U, Ramaswamy V, ... ... Gutmann DH, et al. Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference. Neuro-Oncology. PMID 32055852 DOI: 10.1093/Neuonc/Noaa036  0.417
2020 Gutmann DH. The Sociobiology of Brain Tumors. Advances in Experimental Medicine and Biology. 1225: 115-125. PMID 32030651 DOI: 10.1007/978-3-030-35727-6_8  0.408
2019 Costa AA, Gutmann DH. Brain tumors in Neurofibromatosis type 1. Neuro-Oncology Advances. 1: vdz040. PMID 32642668 DOI: 10.1093/noajnl/vdz040  0.35
2019 Gutmann DH, Kettenmann H. Microglia/Brain Macrophages as Central Drivers of Brain Tumor Pathobiology. Neuron. 104: 442-449. PMID 31697921 DOI: 10.1016/J.Neuron.2019.08.028  0.386
2019 Wong WH, Junck L, Druley TE, Gutmann DH. NF1 glioblastoma clonal profiling reveals mutations as potential somatic oncogenic events. Neurology. PMID 31690684 DOI: 10.1212/Wnl.0000000000008623  0.405
2019 Wright-Jin EC, Gutmann DH. Microglia as Dynamic Cellular Mediators of Brain Function. Trends in Molecular Medicine. PMID 31597593 DOI: 10.1016/J.Molmed.2019.08.013  0.321
2019 Haage V, Elmadany N, Roll L, Faissner A, Gutmann DH, Semtner M, Kettenmann H. Tenascin C regulates multiple microglial functions involving TLR4 signaling and HDAC1. Brain, Behavior, and Immunity. PMID 31271872 DOI: 10.1016/J.Bbi.2019.06.047  0.31
2019 Guo X, Pan Y, Gutmann DH. Genetic and genomic alterations differentially dictate low-grade glioma growth through cancer stem cell-specific chemokine recruitment of T cells and microglia. Neuro-Oncology. PMID 31111915 DOI: 10.1093/Neuonc/Noz080  0.453
2019 Haage V, Semtner M, Vidal RO, Hernandez DP, Pong WW, Chen Z, Hambardzumyan D, Magrini V, Ly A, Walker J, Mardis E, Mertins P, Sauer S, Kettenmann H, Gutmann DH. Comprehensive gene expression meta-analysis identifies signature genes that distinguish microglia from peripheral monocytes/macrophages in health and glioma. Acta Neuropathologica Communications. 7: 20. PMID 30764877 DOI: 10.1186/S40478-019-0665-Y  0.325
2019 Chen R, Keoni C, Waker CA, Lober RM, Gutmann DH. KIAA1549-BRAF Expression Establishes a Permissive Tumor Microenvironment Through NFκB-Mediated CCL2 Production. Neoplasia (New York, N.Y.). 21: 52-60. PMID 30504064 DOI: 10.1016/J.Neo.2018.11.007  0.345
2019 Shih C, Blakeley J, Clapp DW, Armstrong AE, Wolters P, Dombi E, Cutter G, Ullrich NJ, Allen J, Packer R, Goldman S, Gutmann DH, Plotkin S, Rosser T, Robertson K, et al. Abstract CT233: Treatment of neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (PN) with cabozantinib (XL184): A Neurofibromatosis Clinical Trials Consortium Phase II trial Cancer Research. 79. DOI: 10.1158/1538-7445.Am2019-Ct233  0.341
2019 Brossier N, Cobb O, Gutmann D. PDTM-07. DEFINING THE MECHANISMS UNDERLYING NF1 OPTIC GLIOMA PENETRANCE Neuro-Oncology. 21: vi188-vi188. DOI: 10.1093/Neuonc/Noz175.783  0.462
2019 Osum S, Stemmer-Rachamimov A, Widemann B, Dombi E, Vitte J, Dahiya S, Rizvi T, Ratner N, Messiaen L, Gutmann D, Giovannini M, Moertel C, Largaespada D, Watson A. TMOD-23. PRECLINICAL DRUG EVALUATION IN A GENETICALLY ENGINEERED MINIPIG MODEL OF NEUROFIBROMATOSIS TYPE 1 Neuro-Oncology. 21: vi267-vi267. DOI: 10.1093/Neuonc/Noz175.1122  0.419
2018 Freret ME, Anastasaki C, Gutmann DH. Independent mutations underlie café-au-lait macule development in a woman with segmental NF1. Neurology. Genetics. 4: e261. PMID 30065955 DOI: 10.1212/Nxg.0000000000000261  0.369
2018 Zessis NR, Gao F, Vadlamudi G, Gutmann DH, Hollander AS. Height Growth Impairment in Children With Neurofibromatosis Type 1 Is Characterized by Decreased Pubertal Growth Velocity in Both Sexes. Journal of Child Neurology. 883073818786807. PMID 30009646 DOI: 10.1177/0883073818786807  0.301
2018 Pan Y, Duron C, Bush EC, Ma Y, Sims PA, Gutmann DH, Radunskaya A, Hardin J. Graph complexity analysis identifies an ETV5 tumor-specific network in human and murine low-grade glioma. Plos One. 13: e0190001. PMID 29787563 DOI: 10.1371/Journal.Pone.0190001  0.4
2018 Freret ME, Gutmann DH. Insights into optic pathway glioma vision loss from mouse models of neurofibromatosis type 1. Journal of Neuroscience Research. PMID 29704429 DOI: 10.1002/Jnr.24250  0.467
2018 Pan Y, Xiong M, Chen R, Ma Y, Corman C, Maricos M, Kindler U, Semtner M, Chen YH, Dahiya S, Gutmann DH. Athymic mice reveal a requirement for T-cell-microglia interactions in establishing a microenvironment supportive of low-grade glioma growth. Genes & Development. PMID 29632086 DOI: 10.1101/Gad.310797.117  0.331
2018 Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A. A Conserved Circadian Function for the Neurofibromatosis 1 Gene. Cell Reports. 22: 3416-3426. PMID 29590612 DOI: 10.1016/J.Celrep.2018.03.014  0.339
2018 Cimino PJ, Gutmann DH. Neurofibromatosis type 1. Handbook of Clinical Neurology. 148: 799-811. PMID 29478615 DOI: 10.1016/B978-0-444-64076-5.00051-X  0.305
2018 Morris SM, Gutmann DH. A genotype-phenotype correlation for quantitative autistic trait burden in neurofibromatosis 1. Neurology. PMID 29367450 DOI: 10.1212/Wnl.0000000000005000  0.367
2018 Campen CJ, Gutmann DH. Optic Pathway Gliomas in Neurofibromatosis Type 1. Journal of Child Neurology. 33: 73-81. PMID 29246098 DOI: 10.1177/0883073817739509  0.424
2018 Chang E, Zheng Z, Philip L, Burcu C, Lei J, Singh P, Anurag M, Chan D, Li J, Du X, Shafaee M, Banks K, Sacker S, Song W, Nguyen T, ... Gutmann D, et al. Abstract GS2-02: Direct regulation of estrogen receptor-α (ER) transcriptional activity by NF1 Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-Gs2-02  0.376
2018 Chen J, Sinha N, Tihan T, Ersen A, J Phillips J, Gutmann D, Dahiya S. PATH-15. MICROGLIA/MACROPHAGES ARE THE MAJOR TUMOR-ASSOCIATED IMMUNE CELLS IN PILOCYTIC ASTROCYTOMA Neuro-Oncology. 20: vi161-vi161. DOI: 10.1093/Neuonc/Noy148.671  0.338
2018 Shih C, Blakely J, Clapp W, Wolters P, Dombi E, Cutter G, Ullrich N, Allen J, Packer R, Goldman S, Gutmann D, Plotkin S, Rosser T, Robertson K, Widemann B, et al. NFM-01. NF105: A PHASE II PROSPECTIVE STUDY OF CABOZANTINIB (XL184) FOR PLEXIFORM NEUROFIBROMAS IN SUBJECTS WITH NEUROFIBROMATOSIS TYPE 1: A NEUROFIBROMATOSIS CLINICAL TRIAL CONSORTIUM (NFCTC) STUDY Neuro-Oncology. 20: i142-i142. DOI: 10.1093/Neuonc/Noy059.510  0.381
2017 Reilly KM, Kim A, Blakely J, Ferner RE, Gutmann DH, Legius E, Miettinen MM, Randall RL, Ratner N, Jumbé NL, Bakker A, Viskochil D, Widemann BC, Stewart DR. Neurofibromatosis Type 1-Associated MPNST State of the Science: Outlining a Research Agenda for the Future. Journal of the National Cancer Institute. 109. PMID 29117388 DOI: 10.1093/Jnci/Djx124  0.314
2017 Khatua S, Gutmann DH, Packer RJ. Neurofibromatosis type 1 and optic pathway glioma: Molecular interplay and therapeutic insights. Pediatric Blood & Cancer. PMID 29049847 DOI: 10.1002/Pbc.26838  0.46
2017 Zou J, Zhang B, Gutmann DH, Wong M. Postnatal reduction of tuberous sclerosis complex 1 expression in astrocytes and neurons causes seizures in an age-dependent manner. Epilepsia. PMID 29023667 DOI: 10.1111/Epi.13923  0.311
2017 Anastasaki C, Morris SM, Gao F, Gutmann DH. Children with 5'-end NF1 gene mutations are more likely to have glioma. Neurology. Genetics. 3: e192. PMID 28955729 DOI: 10.1212/Nxg.0000000000000192  0.376
2017 Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. Oncotarget. 8: 52474-52487. PMID 28881745 DOI: 10.18632/Oncotarget.17193  0.439
2017 Vogel AC, Gutmann DH, Morris SM. Neurodevelopmental disorders in children with neurofibromatosis type 1. Developmental Medicine and Child Neurology. PMID 28845518 DOI: 10.1111/Dmcn.13526  0.305
2017 Maloney SE, Chandler KC, Anastasaki C, Rieger MA, Gutmann DH, Dougherty JD. Characterization of early communicative behavior in mouse models of neurofibromatosis type 1. Autism Research : Official Journal of the International Society For Autism Research. PMID 28842941 DOI: 10.1002/Aur.1853  0.409
2017 Gutmann DH. The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion. Cell. 170: 821-822. PMID 28841413 DOI: 10.1016/J.Cell.2017.08.011  0.324
2017 de Blank PMK, Fisher MJ, Liu GT, Gutmann DH, Listernick R, Ferner RE, Avery RA. Optic Pathway Gliomas in Neurofibromatosis Type 1: An Update: Surveillance, Treatment Indications, and Biomarkers of Vision. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. 37: S23-S32. PMID 28806346 DOI: 10.1097/Wno.0000000000000550  0.342
2017 Chen R, Pan Y, Gutmann DH. The power of the few. Genes & Development. 31: 1177-1179. PMID 28765159 DOI: 10.1101/Gad.303453.117  0.368
2017 Campian J, Gutmann DH. CNS Tumors in Neurofibromatosis. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. JCO2016717199. PMID 28640700 DOI: 10.1200/Jco.2016.71.7199  0.465
2017 Anastasaki C, Dahiya S, Gutmann DH. KIR2DL5 mutation and loss underlies sporadic dermal neurofibroma pathogenesis and growth. Oncotarget. PMID 28548933 DOI: 10.18632/Oncotarget.17736  0.446
2017 Solga AC, Toonen JA, Pan Y, Cimino PJ, Ma Y, Castillon GA, Gianino SM, Ellisman MH, Lee DY, Gutmann DH. The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. Oncotarget. PMID 28525381 DOI: 10.18632/Oncotarget.17589  0.419
2017 Chheda MG, Gutmann DH. Using Epigenetic Reprogramming to Treat Pediatric Brain Cancer. Cancer Cell. 31: 609-611. PMID 28486100 DOI: 10.1016/J.Ccell.2017.04.008  0.324
2017 Pan Y, Bush EC, Toonen JA, Ma Y, Solga AC, Sims PA, Gutmann DH. Whole tumor RNA-sequencing and deconvolution reveal a clinically-prognostic PTEN/PI3K-regulated glioma transcriptional signature. Oncotarget. PMID 28477028 DOI: 10.18632/oncotarget.17193  0.328
2017 Walter C, Crawford L, Lai M, Toonen JA, Pan Y, Sakiyama-Elbert S, Gutmann DH, Pathak A. Increased Tissue Stiffness in Tumors from Mice with Neurofibromatosis-1 Optic Glioma. Biophysical Journal. 112: 1535-1538. PMID 28445745 DOI: 10.1016/J.Bpj.2017.03.017  0.345
2017 Blakeley JO, Bakker A, Barker A, Clapp W, Ferner R, Fisher MJ, Giovannini M, Gutmann DH, Karajannis MA, Kissil JL, Legius E, Lloyd AC, Packer RJ, Ramesh V, Riccardi VM, et al. The path forward: 2015 International Children's Tumor Foundation conference on neurofibromatosis type 1, type 2, and schwannomatosis. American Journal of Medical Genetics. Part A. PMID 28436162 DOI: 10.1002/Ajmg.A.38239  0.428
2017 Wegscheid ML, Anastasaki C, Gutmann DH. Human stem cell modeling in neurofibromatosis type 1 (NF1). Experimental Neurology. PMID 28392281 DOI: 10.1016/J.Expneurol.2017.04.001  0.424
2017 Pan Y, Smithson LJ, Ma Y, Hambardzumyan D, Gutmann DH. Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival. Oncotarget. PMID 28380429 DOI: 10.18632/Oncotarget.16516  0.428
2017 Mahdi J, Shah AC, Sato A, Morris SM, McKinstry RC, Listernick R, Packer RJ, Fisher MJ, Gutmann DH. A multi-institutional study of brainstem gliomas in children with neurofibromatosis type 1. Neurology. PMID 28330960 DOI: 10.1212/Wnl.0000000000003881  0.319
2017 Chen Z, Feng X, Herting CJ, Alvarez Garcia V, Nie K, Pong WW, Rasmussen R, Dwivedi B, Seby S, Wolf SA, Gutmann DH, Hambardzumyan D. Cellular and molecular identity of tumor-associated macrophages in glioblastoma. Cancer Research. PMID 28235764 DOI: 10.1158/0008-5472.Can-16-2310  0.379
2017 Monroe CL, Dahiya S, Gutmann DH. Dissecting Clinical Heterogeneity in Neurofibromatosis Type 1. Annual Review of Pathology. 12: 53-74. PMID 28135565 DOI: 10.1146/Annurev-Pathol-052016-100228  0.457
2017 Zheng Z, Cakar B, Lavere P, Cao J, Yao J, Singh P, Lei J, Toonen J, Haricharan S, Anurag M, Shah K, Kavuri M, Chan D, Chen X, Gutmann D, et al. Abstract P1-08-01: Regulation of estrogen receptor-α by NF1 Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P1-08-01  0.397
2017 Hirbe AC, Gutmann DH. The management of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors: challenges, progress, and future prospects Expert Opinion On Orphan Drugs. 5: 623-631. DOI: 10.1080/21678707.2017.1348294  0.395
2016 Ricker CA, Pan Y, Gutmann DH, Keller C. Challenges in Drug Discovery for Neurofibromatosis Type 1-Associated Low-Grade Glioma. Frontiers in Oncology. 6: 259. PMID 28066715 DOI: 10.3389/Fonc.2016.00259  0.426
2016 Toonen JA, Ma Y, Gutmann DH. Defining the temporal course of murine neurofibromatosis-1 optic gliomagenesis reveals a therapeutic window to attenuate retinal dysfunction. Neuro-Oncology. PMID 28039362 DOI: 10.1093/Neuonc/Now267  0.322
2016 Ishii T, Ueyama T, Shigyo M, Kohta M, Kondoh T, Kuboyama T, Uebi T, Hamada T, Gutmann DH, Aiba A, Kohmura E, Tohda C, Saito N. A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury. The Journal of Biological Chemistry. PMID 27941025 DOI: 10.1074/Jbc.M116.748871  0.319
2016 Toonen JA, Solga AC, Ma Y, Gutmann DH. Estrogen activation of microglia underlies the sexually dimorphic differences in Nf1 optic glioma-induced retinal pathology. The Journal of Experimental Medicine. PMID 27923908 DOI: 10.1084/Jem.20160447  0.366
2016 Hirbe AC, Kaushal M, Sharma MK, Dahiya S, Pekmezci M, Perry A, Gutmann DH. Clinical genomic profiling identifies TYK2 mutation and overexpression in patients with neurofibromatosis type 1-associated malignant peripheral nerve sheath tumors. Cancer. PMID 27875628 DOI: 10.1002/Cncr.30455  0.413
2016 Morris SM, Acosta MT, Garg S, Green J, Huson S, Legius E, North KN, Payne JM, Plasschaert E, Frazier TW, Weiss LA, Zhang Y, Gutmann DH, Constantino JN. Disease Burden and Symptom Structure of Autism in Neurofibromatosis Type 1: A Study of the International NF1-ASD Consortium Team (INFACT). Jama Psychiatry. PMID 27760236 DOI: 10.1001/Jamapsychiatry.2016.2600  0.322
2016 Morris SM, Monroe CL, Gutmann DH. Macrocephaly Is Not a Predictor of Optic Pathway Glioma Development or Treatment in Neurofibromatosis Type 1. Journal of Child Neurology. PMID 27581847 DOI: 10.1177/0883073816664659  0.354
2016 Li K, Turner AN, Chen M, Brosius SN, Schoeb TR, Messiaen LM, Bedwell DM, Zinn KR, Anastasaki C, Gutmann DH, Korf BR, Kesterson RA. Mice with missense and nonsense NF1 mutations display divergent phenotypes compared with human neurofibromatosis type I. Disease Models & Mechanisms. 9: 759-767. PMID 27482814 DOI: 10.1242/Dmm.025783  0.377
2016 Smithson LJ, Gutmann DH. Proteomic analysis reveals GIT1 as a novel mTOR complex component critical for mediating astrocyte survival. Genes & Development. 30: 1383-8. PMID 27340174 DOI: 10.1101/Gad.279661.116  0.318
2016 Smithson LJ, Anastasaki C, Chen R, Toonen JA, Williams SB, Gutmann DH. Contextual signaling in cancer. Seminars in Cell & Developmental Biology. PMID 27269372 DOI: 10.1016/J.Semcdb.2016.06.002  0.343
2016 Johnson KJ, Zoellner NL, Gutmann DH. Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1. Cancer Epidemiology. 42: 53-59. PMID 27018750 DOI: 10.1016/J.Canep.2016.03.005  0.41
2016 Chen YH, Cimino PJ, Luo J, Dahiya S, Gutmann DH. ABCG1 maintains high-grade glioma survival in vitro and in vivo. Oncotarget. PMID 26981778 DOI: 10.18632/Oncotarget.8030  0.334
2016 Zafar R, Hsiao EY, Botteron KN, McKinstry RC, Gutmann DH. De novo development of gliomas in a child with neurofibromatosis type 1, fragile X and previously normal brain magnetic resonance imaging. Radiology Case Reports. 11: 33-5. PMID 26973730 DOI: 10.1016/J.Radcr.2015.12.008  0.321
2016 Toonen JA, Anastasaki C, Smithson LJ, Gianino SM, Li K, Kesterson RA, Gutmann DH. NF1 Germline Mutation Differentially Dictates Optic Glioma Formation and Growth in Neurofibromatosis-1. Human Molecular Genetics. PMID 26908603 DOI: 10.1093/Hmg/Ddw039  0.423
2016 Anderson DM, Van de Plas R, Rose KL, Hill S, Schey KL, Solga AC, Gutmann DH, Caprioli RM. 3-D imaging mass spectrometry of protein distributions in mouse Neurofibromatosis 1 (NF1)-associated optic glioma. Journal of Proteomics. PMID 26883872 DOI: 10.1016/J.Jprot.2016.02.004  0.371
2016 Hirbe AC, Dahiya S, Friedmann-Morvinski D, Verma IM, Clapp DW, Gutmann DH. Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation. Oncotarget. PMID 26859681 DOI: 10.18632/Oncotarget.7232  0.453
2016 Ceccarelli M, Barthel FP, Malta TM, Sabedot TS, Salama SR, Murray BA, Morozova O, Newton Y, Radenbaugh A, Pagnotta SM, Anjum S, Wang J, Manyam G, Zoppoli P, Ling S, ... ... Gutmann DH, et al. Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. Cell. 164: 550-563. PMID 26824661 DOI: 10.1016/J.Cell.2015.12.028  0.31
2016 Chen Z, Feng X, Nie K, Pong WW, Rasmussen R, Gutmann D, Hambardzumyan D. TMIC-06. IDENTITY AND GENE PROFILE OF TUMOR-ASSOCIATED MACROPHAGES IN GLIOBLASTOMA Neuro-Oncology. 18: vi200-vi201. DOI: 10.1093/Neuonc/Now212.846  0.357
2015 Hambardzumyan D, Gutmann DH, Kettenmann H. The role of microglia and macrophages in glioma maintenance and progression. Nature Neuroscience. 19: 20-7. PMID 26713745 DOI: 10.1038/Nn.4185  0.405
2015 Porcelli B, Zoellner NL, Abadin SS, Gutmann DH, Johnson KJ. Associations between allergic conditions and pediatric brain tumors in Neurofibromatosis type 1. Familial Cancer. PMID 26666764 DOI: 10.1007/S10689-015-9855-3  0.357
2015 Baker SJ, Ellison DW, Gutmann DH. Pediatric gliomas as neurodevelopmental disorders. Glia. PMID 26638183 DOI: 10.1002/Glia.22945  0.384
2015 Solga AC, Pong WW, Kim KY, Cimino PJ, Toonen JA, Walker J, Wylie T, Magrini V, Griffith M, Griffith OL, Ly A, Ellisman MH, Mardis ER, Gutmann DH. RNA Sequencing of Tumor-Associated Microglia Reveals Ccl5 as a Stromal Chemokine Critical for Neurofibromatosis-1 Glioma Growth. Neoplasia (New York, N.Y.). 17: 776-88. PMID 26585233 DOI: 10.1016/J.Neo.2015.10.002  0.427
2015 Anderson JL, Gutmann DH. Neurofibromatosis type 1. Handbook of Clinical Neurology. 132: 75-86. PMID 26564071 DOI: 10.1016/B978-0-444-62702-5.00004-4  0.411
2015 Chen YH, Gianino SM, Gutmann DH. Neurofibromatosis-1 regulation of neural stem cell proliferation and multilineage differentiation operates through distinct RAS effector pathways. Genes & Development. 29: 1677-82. PMID 26272820 DOI: 10.1101/Gad.261677.115  0.349
2015 Constantino JN, Zhang Y, Holzhauer K, Sant S, Long K, Vallorani A, Malik L, Gutmann DH. Distribution and Within-Family Specificity of Quantitative Autistic Traits in Patients with Neurofibromatosis Type I. The Journal of Pediatrics. 167: 621-6.e1. PMID 26051969 DOI: 10.1016/J.Jpeds.2015.04.075  0.307
2015 Abadin SS, Zoellner NL, Schaeffer M, Porcelli B, Gutmann DH, Johnson KJ. Racial/Ethnic Differences in Pediatric Brain Tumor Diagnoses in Patients with Neurofibromatosis Type 1. The Journal of Pediatrics. PMID 26028287 DOI: 10.1016/J.Jpeds.2015.04.076  0.378
2015 Hirbe AC, Dahiya S, Miller CA, Li T, Fulton RS, Zhang X, McDonald S, DeSchryver K, Duncavage EJ, Walrath J, Reilly KM, Abel HJ, Pekmezci M, Perry A, Ley TJ, ... Gutmann DH, et al. Whole Exome Sequencing Reveals the Order of Genetic Changes during Malignant Transformation and Metastasis in a Single Patient with NF1-plexiform Neurofibroma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25925892 DOI: 10.1158/1078-0432.Ccr-14-3049  0.4
2015 Omrani A, van der Vaart T, Mientjes E, van Woerden GM, Hojjati MR, Li KW, Gutmann DH, Levelt CN, Smit AB, Silva AJ, Kushner SA, Elgersma Y. HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1. Molecular Psychiatry. PMID 25917366 DOI: 10.1038/Mp.2015.48  0.36
2015 Anastasaki C, Woo AS, Messiaen LM, Gutmann DH. Elucidating the impact of neurofibromatosis-1 germline mutations on neurofibromin function and dopamine-based learning. Human Molecular Genetics. 24: 3518-28. PMID 25788518 DOI: 10.1093/Hmg/Ddv103  0.393
2015 Chen YH, McGowan LD, Cimino PJ, Dahiya S, Leonard JR, Lee da Y, Gutmann DH. Mouse low-grade gliomas contain cancer stem cells with unique molecular and functional properties. Cell Reports. 10: 1899-912. PMID 25772366 DOI: 10.1016/J.Celrep.2015.02.041  0.363
2015 Brossier NM, Gutmann DH. Improving outcomes for neurofibromatosis 1-associated brain tumors. Expert Review of Anticancer Therapy. 15: 415-23. PMID 25652347 DOI: 10.1586/14737140.2015.1009043  0.431
2015 Kaul A, Toonen JA, Cimino PJ, Gianino SM, Gutmann DH. Akt- or MEK-mediated mTOR inhibition suppresses Nf1 optic glioma growth. Neuro-Oncology. 17: 843-53. PMID 25534823 DOI: 10.1093/Neuonc/Nou329  0.377
2015 Gutmann DH. Microglia in the tumor microenvironment: taking their TOLL on glioma biology. Neuro-Oncology. 17: 171-3. PMID 25523594 DOI: 10.1093/Neuonc/Nou346  0.435
2015 Liu Q, Zoellner N, Gutmann DH, Johnson KJ. Parental age and Neurofibromatosis Type 1: a report from the NF1 Patient Registry Initiative. Familial Cancer. 14: 317-24. PMID 25523354 DOI: 10.1007/S10689-014-9774-8  0.353
2015 Rauen KA, Huson SM, Burkitt-Wright E, Evans DG, Farschtschi S, Ferner RE, Gutmann DH, Hanemann CO, Kerr B, Legius E, Parada LF, Patton M, Peltonen J, Ratner N, Riccardi VM, et al. Recent developments in neurofibromatoses and RASopathies: management, diagnosis and current and future therapeutic avenues. American Journal of Medical Genetics. Part A. 167: 1-10. PMID 25393061 DOI: 10.1002/Ajmg.A.36793  0.34
2015 Warrington NM, Sun T, Luo J, McKinstry RC, Parkin PC, Ganzhorn S, Spoljaric D, Albers AC, Merkelson A, Stewart DR, Stevenson DA, Viskochil D, Druley TE, Forys JT, Reilly KM, ... ... Gutmann DH, et al. The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients. Cancer Research. 75: 16-21. PMID 25381154 DOI: 10.1158/0008-5472.Can-14-1891  0.34
2015 Weiss B, Widemann BC, Wolters P, Dombi E, Vinks A, Cantor A, Perentesis J, Schorry E, Ullrich N, Gutmann DH, Tonsgard J, Viskochil D, Korf B, Packer RJ, Fisher MJ. Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study. Neuro-Oncology. 17: 596-603. PMID 25314964 DOI: 10.1093/Neuonc/Nou235  0.419
2015 Solga AC, Pong WW, Walker J, Wylie T, Magrini V, Apicelli AJ, Griffith M, Griffith OL, Kohsaka S, Wu GF, Brody DL, Mardis ER, Gutmann DH. RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. Glia. 63: 531-48. PMID 25258010 DOI: 10.1002/Glia.22754  0.336
2015 Kaul A, Toonen JA, Gianino SM, Gutmann DH. The impact of coexisting genetic mutations on murine optic glioma biology. Neuro-Oncology. 17: 670-7. PMID 25246427 DOI: 10.1093/Neuonc/Nou287  0.44
2015 Pekmezci M, Reuss DE, Hirbe AC, Dahiya S, Gutmann DH, von Deimling A, Horvai AE, Perry A. Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 28: 187-200. PMID 25189642 DOI: 10.1038/Modpathol.2014.109  0.355
2015 Pachow D, Wick W, Gutmann DH, Mawrin C. The mTOR signaling pathway as a treatment target for intracranial neoplasms. Neuro-Oncology. 17: 189-99. PMID 25165193 DOI: 10.1093/Neuonc/Nou164  0.38
2015 Johnson K, Porcelli B, Zoellner N, Abadin S, Gutmann D. EPID-18THE ASSOCIATION BETWEEN ALLERGIC CONDITIONS AND PEDIATRIC BRAIN TUMORS IN NEUROFIBROMATOSIS TYPE 1 Neuro-Oncology. 17: v81.5-v82. DOI: 10.1093/Neuonc/Nov213.18  0.357
2015 Darken RS, Gutmann DH. Neuroibromatosis type I Molecular Oncology: Causes of Cancer and Targets For Treatment. 679-685. DOI: 10.1017/CBO9781139046947.061  0.306
2014 Gutmann DH. NF GEMMs already! The power and promise of mouse tumor models. Cancer Cell. 26: 596-9. PMID 25517743 DOI: 10.1016/J.Ccell.2014.10.007  0.425
2014 Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM, Giovannini M, Gutmann DH, Kalamarides M, McClatchey AI, Messiaen L, Morrison H, et al. Update from the 2013 International Neurofibromatosis Conference. American Journal of Medical Genetics. Part A. 164: 2969-78. PMID 25255738 DOI: 10.1002/Ajmg.A.36754  0.436
2014 Huang YC, Wei KC, Chang CN, Chen PY, Hsu PW, Chen CP, Lu CS, Wang HL, Gutmann DH, Yeh TH. Transglutaminase 2 expression is increased as a function of malignancy grade and negatively regulates cell growth in meningioma. Plos One. 9: e108228. PMID 25247996 DOI: 10.1371/Journal.Pone.0108228  0.405
2014 Schwetye KE, Gutmann DH. Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions. Expert Review of Neurotherapeutics. 14: 1139-52. PMID 25161109 DOI: 10.1586/14737175.2014.953931  0.311
2014 Anastasaki C, Gutmann DH. Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation. Human Molecular Genetics. 23: 6712-21. PMID 25070947 DOI: 10.1093/Hmg/Ddu389  0.352
2014 Gutmann DH. Eliminating barriers to personalized medicine: learning from neurofibromatosis type 1. Neurology. 83: 463-71. PMID 24975854 DOI: 10.1212/Wnl.0000000000000652  0.387
2014 Weiss B, Widemann BC, Wolters P, Dombi E, Vinks AA, Cantor A, Korf B, Perentesis J, Gutmann DH, Schorry E, Packer R, Fisher MJ. Sirolimus for non-progressive NF1-associated plexiform neurofibromas: an NF clinical trials consortium phase II study. Pediatric Blood & Cancer. 61: 982-6. PMID 24851266 DOI: 10.1002/Pbc.24873  0.457
2014 Garcia C, Gutmann DH. Nf2/Merlin controls spinal cord neural progenitor function in a Rac1/ErbB2-dependent manner. Plos One. 9: e97320. PMID 24817309 DOI: 10.1371/Journal.Pone.0097320  0.313
2014 Kumar MG, Emnett RJ, Bayliss SJ, Gutmann DH. Glomus tumors in individuals with neurofibromatosis type 1. Journal of the American Academy of Dermatology. 71: 44-8. PMID 24685357 DOI: 10.1016/J.Jaad.2014.01.913  0.399
2014 Gavilan HS, Kulikauskas RM, Gutmann DH, Fehon RG. In vivo functional analysis of the human NF2 tumor suppressor gene in Drosophila. Plos One. 9: e90853. PMID 24595234 DOI: 10.1371/Journal.Pone.0090853  0.382
2014 Widemann BC, Acosta MT, Ammoun S, Belzberg AJ, Bernards A, Blakeley J, Bretscher A, Cichowski K, Clapp DW, Dombi E, Evans GD, Ferner R, Fernandez-Valle C, Fisher MJ, Giovannini M, ... Gutmann DH, et al. CTF meeting 2012: Translation of the basic understanding of the biology and genetics of NF1, NF2, and schwannomatosis toward the development of effective therapies. American Journal of Medical Genetics. Part A. 164: 563-78. PMID 24443315 DOI: 10.1002/Ajmg.A.36312  0.439
2014 Gomez GG, Volinia S, Croce CM, Zanca C, Li M, Emnett R, Gutmann DH, Brennan CW, Furnari FB, Cavenee WK. Suppression of microRNA-9 by mutant EGFR signaling upregulates FOXP1 to enhance glioblastoma tumorigenicity. Cancer Research. 74: 1429-39. PMID 24436148 DOI: 10.1158/0008-5472.Can-13-2117  0.3
2014 Diggs-Andrews KA, Brown JA, Gianino SM, Rubin JB, Wozniak DF, Gutmann DH. Sex Is a major determinant of neuronal dysfunction in neurofibromatosis type 1. Annals of Neurology. 75: 309-16. PMID 24375753 DOI: 10.1002/Ana.24093  0.402
2014 Hirbe AC, Pekmezci M, Dahiya S, Apicelli AJ, Van Tine BA, Perry A, Gutmann DH. BRAFV600E mutation in sporadic and neurofibromatosis type 1-related malignant peripheral nerve sheath tumors. Neuro-Oncology. 16: 466-7. PMID 24366910 DOI: 10.1093/Neuonc/Not248  0.418
2014 Dahiya S, Emnett RJ, Haydon DH, Leonard JR, Phillips JJ, Perry A, Gutmann DH. BRAF-V600E mutation in pediatric and adult glioblastoma. Neuro-Oncology. 16: 318-9. PMID 24311634 DOI: 10.1093/Neuonc/Not146  0.346
2014 Chen YH, Gutmann DH. The molecular and cell biology of pediatric low-grade gliomas Oncogene. 33: 2019-2026. PMID 23624918 DOI: 10.1038/onc.2013.148  0.38
2014 Solga AC, Gianino SM, Gutmann DH. NG2-cells are not the cell of origin for murine neurofibromatosis-1 (Nf1) optic glioma Oncogene. 33: 289-299. PMID 23318450 DOI: 10.1038/Onc.2012.580  0.422
2014 Johnson KJ, Mueller N, Sharkey E, Liu Q, Gutmann DH. Abstract 1295: The association between asthma and pediatric brain tumors in neurofibromatosis type 1 Cancer Research. 74: 1295-1295. DOI: 10.1158/1538-7445.Am2014-1295  0.392
2014 Solga AC, Pong WW, Cimino PJ, Kim KY, Walker J, Wylie T, Magrini V, Rubin JB, Piwnica-Worms D, Ellisman MH, Mardis ER, Gutmann DH. Abstract 1074: Tumor-associated microglia secrete paracrine factors that promote Nf1-deficient optic glial cell growth Cancer Research. 74: 1074-1074. DOI: 10.1158/1538-7445.Am2014-1074  0.458
2014 Ostendorf AP, Gutmann DH. Neurofibromatoses Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease: Fifth Edition. 921-933. DOI: 10.1016/B978-0-12-410529-4.00079-6  0.342
2013 Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Leonard JR, Zipfel GJ, Chicoine MR. Antiangiogenic agents for nonmalignant brain tumors. Journal of Neurological Surgery. Part B, Skull Base. 74: 136-41. PMID 24436903 DOI: 10.1055/S-0033-1338262  0.334
2013 Pong WW, Walker J, Wylie T, Magrini V, Luo J, Emnett RJ, Choi J, Cooper ML, Griffith M, Griffith OL, Rubin JB, Fuller GN, Piwnica-Worms D, Feng X, Hambardzumyan D, ... ... Gutmann DH, et al. F11R is a novel monocyte prognostic biomarker for malignant glioma. Plos One. 8: e77571. PMID 24147027 DOI: 10.1371/Journal.Pone.0077571  0.372
2013 Lin AL, Gutmann DH. Advances in the treatment of neurofibromatosis-associated tumours. Nature Reviews. Clinical Oncology. 10: 616-24. PMID 23939548 DOI: 10.1038/Nrclinonc.2013.144  0.408
2013 Ferner RE, Gutmann DH. Neurofibromatosis type 1 (NF1): diagnosis and management. Handbook of Clinical Neurology. 115: 939-55. PMID 23931823 DOI: 10.1016/B978-0-444-52902-2.00053-9  0.44
2013 Kaul A, Chen YH, Emnett RJ, Gianino SM, Gutmann DH. Conditional KIAA1549:BRAF mice reveal brain region- and cell type-specific effects. Genesis (New York, N.Y. : 2000). 51: 708-16. PMID 23893969 DOI: 10.1002/Dvg.22415  0.316
2013 Wozniak DF, Diggs-Andrews KA, Conyers S, Yuede CM, Dearborn JT, Brown JA, Tokuda K, Izumi Y, Zorumski CF, Gutmann DH. Motivational disturbances and effects of L-dopa administration in neurofibromatosis-1 model mice. Plos One. 8: e66024. PMID 23762458 DOI: 10.1371/Journal.Pone.0066024  0.332
2013 Dahiya S, Haydon DH, Alvarado D, Gurnett CA, Gutmann DH, Leonard JR. BRAF(V600E) mutation is a negative prognosticator in pediatric ganglioglioma. Acta Neuropathologica. 125: 901-10. PMID 23609006 DOI: 10.1007/S00401-013-1120-Y  0.355
2013 O'Brien DE, Brenner DS, Gutmann DH, Gereau RW. Assessment of pain and itch behavior in a mouse model of neurofibromatosis type 1. The Journal of Pain : Official Journal of the American Pain Society. 14: 628-37. PMID 23578956 DOI: 10.1016/J.Jpain.2013.01.770  0.387
2013 Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C, Mautner VF, Hanemann CO, Dun XP, Parkinson DB, Weis J, Schröder JM, ... Gutmann DH, et al. Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nature Neuroscience. 16: 426-33. PMID 23455610 DOI: 10.1038/Nn.3348  0.402
2013 Gutmann DH, Blakeley JO, Korf BR, Packer RJ. Optimizing biologically targeted clinical trials for neurofibromatosis. Expert Opinion On Investigational Drugs. 22: 443-62. PMID 23425047 DOI: 10.1517/13543784.2013.772979  0.398
2013 Pong WW, Higer SB, Gianino SM, Emnett RJ, Gutmann DH. Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation. Annals of Neurology. 73: 303-8. PMID 23424002 DOI: 10.1002/Ana.23813  0.395
2013 Karasinska JM, de Haan W, Franciosi S, Ruddle P, Fan J, Kruit JK, Stukas S, Lütjohann D, Gutmann DH, Wellington CL, Hayden MR. ABCA1 influences neuroinflammation and neuronal death. Neurobiology of Disease. 54: 445-55. PMID 23376685 DOI: 10.1016/J.Nbd.2013.01.018  0.318
2013 Diggs-Andrews KA, Gutmann DH. Modeling cognitive dysfunction in neurofibromatosis-1. Trends in Neurosciences. 36: 237-47. PMID 23312374 DOI: 10.1016/J.Tins.2012.12.002  0.313
2013 Johnson KJ, Hussain I, Williams K, Santens R, Mueller NL, Gutmann DH. Development of an international internet-based neurofibromatosis Type 1 patient registry. Contemporary Clinical Trials. 34: 305-11. PMID 23246715 DOI: 10.1016/J.Cct.2012.12.002  0.307
2013 Gutmann DH, McLellan MD, Hussain I, Wallis JW, Fulton LL, Fulton RS, Magrini V, Demeter R, Wylie T, Kandoth C, Leonard JR, Guha A, Miller CA, Ding L, Mardis ER. Somatic neurofibromatosis type 1 (NF1) inactivation characterizes NF1-associated pilocytic astrocytoma. Genome Research. 23: 431-9. PMID 23222849 DOI: 10.1101/Gr.142604.112  0.47
2013 Wessel LE, Albers AC, Gutmann DH, Dunn CM. The association between hypotonia and brain tumors in children with neurofibromatosis type 1. Journal of Child Neurology. 28: 1664-7. PMID 23071069 DOI: 10.1177/0883073812460918  0.361
2013 Soucy EA, van Oppen D, Nejedly NL, Gao F, Gutmann DH, Hollander AS. Height assessments in children with neurofibromatosis type 1. Journal of Child Neurology. 28: 303-7. PMID 22752476 DOI: 10.1177/0883073812446310  0.326
2013 Johnson KJ, Mueller NL, Gutmann DH. Abstract 4847: Efficacy of different recruitment methods for a neurofibromatosis type 1 online registry. Cancer Research. 73: 4847-4847. DOI: 10.1158/1538-7445.Am2013-4847  0.302
2013 Solga AC, Gianino SM, Gutmann DH. Abstract 358: Nf1 inactivation in NG2-cells is not sufficient for murine optic glioma formation. Cancer Research. 73: 358-358. DOI: 10.1158/1538-7445.Am2013-358  0.418
2013 Kaul A, Chen Y, Emnett RJ, Dahiya S, Gutmann D. Abstract 2322: TheKIAA1549:BRAFfusion gene regulates mTOR signaling and gliomagenesis in a cell type- and brain region-specific manner. Cancer Research. 73: 2322-2322. DOI: 10.1158/1538-7445.Am2013-2322  0.4
2013 Hawasli AH, Rubin JB, Tran DD, Adkins DR, Waheed S, Hullar TE, Gutmann DH, Evans J, Chicoine MR. Anti-Angiogenic Agents for Non-Malignant Brain Tumors Skull Base Surgery. 74. DOI: 10.1055/S-0033-1336173  0.325
2013 Kaul A, Hussain I, Gutmann DH. Using genetically engineered mouse models to understand low-grade glioma development and growth in children Neuromethods. 77: 203-215. DOI: 10.1007/7657_2011_29  0.314
2012 Kaul A, Chen YH, Emnett RJ, Dahiya S, Gutmann DH. Pediatric glioma-associated KIAA1549:BRAF expression regulates neuroglial cell growth in a cell type-specific and mTOR-dependent manner. Genes & Development. 26: 2561-6. PMID 23152448 DOI: 10.1101/Gad.200907.112  0.364
2012 Kliese N, Gobrecht P, Pachow D, Andrae N, Wilisch-Neumann A, Kirches E, Riek-Burchardt M, Angenstein F, Reifenberger G, Riemenschneider MJ, Meese E, Panayotova-Dimitrova D, Gutmann DH, Mawrin C. miRNA-145 is downregulated in atypical and anaplastic meningiomas and negatively regulates motility and proliferation of meningioma cells. Oncogene. 32: 4712-20. PMID 23108408 DOI: 10.1038/Onc.2012.468  0.309
2012 Gutmann DH, Parada LF, Silva AJ, Ratner N. Neurofibromatosis type 1: modeling CNS dysfunction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14087-93. PMID 23055477 DOI: 10.1523/Jneurosci.3242-12.2012  0.411
2012 Avery RA, Ferner RE, Listernick R, Fisher MJ, Gutmann DH, Liu GT. Visual acuity in children with low grade gliomas of the visual pathway: implications for patient care and clinical research. Journal of Neuro-Oncology. 110: 1-7. PMID 22843451 DOI: 10.1007/S11060-012-0944-Y  0.32
2012 Johnson KJ, Fisher MJ, Listernick RL, North KN, Schorry EK, Viskochil D, Weinstein M, Rubin JB, Gutmann DH. Parent-of-origin in individuals with familial neurofibromatosis type 1 and optic pathway gliomas. Familial Cancer. 11: 653-6. PMID 22829012 DOI: 10.1007/S10689-012-9549-Z  0.415
2012 Acosta MT, Bearden CE, Castellanos FX, Castellanos XF, Cutting L, Elgersma Y, Gioia G, Gutmann DH, Lee YS, Legius E, Muenke M, North K, Parada LF, Ratner N, Hunter-Schaedle K, et al. The Learning Disabilities Network (LeaDNet): using neurofibromatosis type 1 (NF1) as a paradigm for translational research. American Journal of Medical Genetics. Part A. 158: 2225-32. PMID 22821737 DOI: 10.1002/Ajmg.A.35535  0.324
2012 Lee da Y, Gianino SM, Gutmann DH. Innate neural stem cell heterogeneity determines the patterning of glioma formation in children. Cancer Cell. 22: 131-8. PMID 22789544 DOI: 10.1016/J.Ccr.2012.05.036  0.35
2012 Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development (Cambridge, England). 139: 2477-87. PMID 22675209 DOI: 10.1242/Jcs.116657  0.319
2012 Dahiya S, Yu J, Kaul A, Leonard JR, Gutmann DH. Novel BRAF Alteration in a Sporadic Pilocytic Astrocytoma. Case Reports in Medicine. 2012: 418672. PMID 22548077 DOI: 10.1155/2012/418672  0.405
2012 Weber JD, Gutmann DH. Deconvoluting mTOR biology. Cell Cycle (Georgetown, Tex.). 11: 236-48. PMID 22214661 DOI: 10.4161/Cc.11.2.19022  0.319
2012 Brown JA, Diggs-Andrews KA, Gianino SM, Gutmann DH. Neurofibromatosis-1 heterozygosity impairs CNS neuronal morphology in a cAMP/PKA/ROCK-dependent manner. Molecular and Cellular Neurosciences. 49: 13-22. PMID 21903164 DOI: 10.1016/J.Mcn.2011.08.008  0.375
2012 Johnson KJ, Hussain I, Ferguson T, Gutmann DH. Abstract 5521: Development of a web-based patient registry and DNA repository for pediatric cancer research in individuals with neurofibromatosis type 1 Cancer Research. 72: 5521-5521. DOI: 10.1158/1538-7445.Am2012-5521  0.342
2012 Kaul A, Solga A, Lee DY, Gianino SM, Gutmann DH. Abstract 2498: Differential rapamycin sensitivity distinguishes two distinct populations of tumor cells in murine glioma Cancer Research. 72: 2498-2498. DOI: 10.1158/1538-7445.Am2012-2498  0.429
2012 Pong WW, Higer SB, Gianino SM, Gutmann DH. Abstract 1530: The obligate role of microglia in tumorigenesis in a mouse model of neurofibromatosis-1 optic glioma Cancer Research. 72: 1530-1530. DOI: 10.1158/1538-7445.Am2012-1530  0.434
2012 Thangarajh M, Gutmann DH. Low-grade gliomas as neurodevelopmental disorders: Insights from mouse models of neurofibromatosis-1 Neuropathology and Applied Neurobiology. 38: 241-253. DOI: 10.1111/J.1365-2990.2011.01230.X  0.381
2012 Solga AC, Gutmann DH. NF1-associated optic glioma Neurofibromatosis Type 1: Molecular and Cellular Biology. 2147483647: 341-352. DOI: 10.1007/978-3-642-32864-0_22  0.332
2011 Brown JA, Xu J, Diggs-Andrews KA, Wozniak DF, Mach RH, Gutmann DH. PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice. Experimental Neurology. 232: 333-8. PMID 21963652 DOI: 10.1016/J.Expneurol.2011.09.005  0.314
2011 Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH. Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 15996-6001. PMID 21896734 DOI: 10.1073/Pnas.1019012108  0.447
2011 Deshmukh H, Yu J, Shaik J, MacDonald TJ, Perry A, Payton JE, Gutmann DH, Watson MA, Nagarajan R. Identification of transcriptional regulatory networks specific to pilocytic astrocytoma. Bmc Medical Genomics. 4: 57. PMID 21745356 DOI: 10.1186/1755-8794-4-57  0.375
2011 Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL. Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro-Oncology. 13: 692-9. PMID 21727208 DOI: 10.1093/Neuonc/Nor080  0.33
2011 Dahiya S, Lee DY, Gutmann DH. Comparative characterization of the human and mouse third ventricle germinal zones Journal of Neuropathology and Experimental Neurology. 70: 622-633. PMID 21666496 DOI: 10.1097/Nen.0B013E31822200Aa  0.368
2011 Yu J, Deshmukh H, Payton JE, Dunham C, Scheithauer BW, Tihan T, Prayson RA, Guha A, Bridge JA, Ferner RE, Lindberg GM, Gutmann RJ, Emnett RJ, Salavaggione L, Gutmann DH, et al. Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 1924-34. PMID 21325289 DOI: 10.1158/1078-0432.Ccr-10-1551  0.34
2011 Crouse NR, Dahiya S, Gutmann DH. Rethinking Pediatric Gliomas as Developmental Brain Abnormalities Current Topics in Developmental Biology. 94: 283-308. PMID 21295690 DOI: 10.1016/B978-0-12-380916-2.00009-7  0.42
2011 Gutmann DH, Listernick R, Ferner RE. Screening for symptomatic optic pathway glioma in children with neurofibromatosis type 1 Eye. 25: 818. PMID 21274014 DOI: 10.1038/Eye.2010.227  0.308
2011 Kalamarides M, Stemmer-Rachamimov AO, Niwa-Kawakita M, Chareyre F, Taranchon E, Han ZY, Martinelli C, Lusis EA, Hegedus B, Gutmann DH, Giovannini M. Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes. Oncogene. 30: 2333-44. PMID 21242963 DOI: 10.1038/Onc.2010.609  0.381
2011 Banerjee S, Gianino SM, Gao F, Christians U, Gutmann DH. Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes. Molecular Cancer Therapeutics. 10: 279-91. PMID 21216928 DOI: 10.1158/1535-7163.Mct-10-0654  0.397
2011 Stuart JE, Lusis EA, Scheck AC, Coons SW, Lal A, Perry A, Gutmann DH. Identification of gene markers associated with aggressive meningioma by filtering across multiple sets of gene expression arrays. Journal of Neuropathology and Experimental Neurology. 70: 1-12. PMID 21157382 DOI: 10.1097/Nen.0B013E3182018F1C  0.323
2011 Simmons GW, Pong WW, Emnett RJ, White CR, Gianino SM, Rodriguez FJ, Gutmann DH. Neurofibromatosis-1 heterozygosity increases microglia in a spatially and temporally restricted pattern relevant to mouse optic glioma formation and growth. Journal of Neuropathology and Experimental Neurology. 70: 51-62. PMID 21157378 DOI: 10.1097/Nen.0B013E3182032D37  0.43
2011 Pong WW, Gutmann DH. The ecology of brain tumors: Lessons learned from neurofibromatosis-1 Oncogene. 30: 1135-1146. PMID 21076468 DOI: 10.1038/Onc.2010.519  0.426
2011 Wang L, Gutmann DH, Roos RP. Astrocyte loss of mutant SOD1 delays ALS disease onset and progression in G85R transgenic mice. Human Molecular Genetics. 20: 286-93. PMID 20962037 DOI: 10.1093/Hmg/Ddq463  0.31
2011 Zhan Y, Modi N, Stewart AM, Hieronimus RI, Liu J, Gutmann DH, Chadee DN. Regulation of mixed lineage kinase 3 is required for Neurofibromatosis-2-mediated growth suppression in human cancer. Oncogene. 30: 781-9. PMID 20890305 DOI: 10.1038/Onc.2010.453  0.348
2011 Hussain I, Gutmann DH. Molecular genetics of optic glioma: Lessons learned from neurofibromatosis-1 genetically engineered mice Expert Review of Ophthalmology. 6: 363-369. DOI: 10.1586/Eop.11.31  0.351
2011 Gibson P, Tong Y, Robinson G, Poppleton H, Thompson MC, Currle DS, Eden C, Hogg TL, Finkelstein D, Pounds S, Patay Z, Scoggins M, Pei Y, Ogg R, Lee Y, ... ... Gutmann DH, et al. Abstract 3448: Subtypes of medulloblastoma have distinct developmental origins Cancer Research. 71: 3448-3448. DOI: 10.1158/1538-7445.Am2011-3448  0.427
2010 Gibson P, Tong Y, Robinson G, Thompson MC, Currle DS, Eden C, Kranenburg TA, Hogg T, Poppleton H, Martin J, Finkelstein D, Pounds S, Weiss A, Patay Z, Scoggins M, ... ... Gutmann DH, et al. Subtypes of medulloblastoma have distinct developmental origins. Nature. 468: 1095-9. PMID 21150899 DOI: 10.1038/Nature09587  0.369
2010 Zeng LH, Rensing NR, Zhang B, Gutmann DH, Gambello MJ, Wong M. Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex. Human Molecular Genetics. 20: 445-54. PMID 21062901 DOI: 10.1093/Hmg/Ddq491  0.321
2010 Lee DY, Yeh TH, Emnett RJ, White CR, Gutmann DH. Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner. Genes & Development. 24: 2317-29. PMID 20876733 DOI: 10.1101/Gad.1957110  0.365
2010 Brown JA, Emnett RJ, White CR, Yuede CM, Conyers SB, O'Malley KL, Wozniak DF, Gutmann DH. Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice. Human Molecular Genetics. 19: 4515-28. PMID 20826448 DOI: 10.1093/Hmg/Ddq382  0.368
2010 Kim KY, Ju WK, Hegedus B, Gutmann DH, Ellisman MH. Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma. Neuroscience. 170: 178-88. PMID 20600672 DOI: 10.1016/J.Neuroscience.2010.06.017  0.368
2010 Sun T, Gianino SM, Jackson E, Piwnica-Worms D, Gutmann DH, Rubin JB. CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice. Journal of Neuroimmunology. 224: 108-13. PMID 20554030 DOI: 10.1016/J.Jneuroim.2010.05.002  0.413
2010 Warrington NM, Gianino SM, Jackson E, Goldhoff P, Garbow JR, Piwnica-Worms D, Gutmann DH, Rubin JB. Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1. Cancer Research. 70: 5717-27. PMID 20551058 DOI: 10.1158/0008-5472.Can-09-3769  0.456
2010 Haase D, Schmidl S, Ewald C, Kalff R, Huebner C, Firsching R, Keilhoff G, Evert M, Paulus W, Gutmann DH, Lal A, Mawrin C. Fatty acid synthase as a novel target for meningioma therapy. Neuro-Oncology. 12: 844-54. PMID 20511185 DOI: 10.1093/Neuonc/Noq004  0.385
2010 Brown JA, Gianino SM, Gutmann DH. Defective cAMP generation underlies the sensitivity of CNS neurons to neurofibromatosis-1 heterozygosity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 5579-89. PMID 20410111 DOI: 10.1523/Jneurosci.3994-09.2010  0.357
2010 Banerjee S, Byrd JN, Gianino SM, Harpstrite SE, Rodriguez FJ, Tuskan RG, Reilly KM, Piwnica-Worms DR, Gutmann DH. The neurofibromatosis type 1 tumor suppressor controls cell growth by regulating signal transducer and activator of transcription-3 activity in vitro and in vivo. Cancer Research. 70: 1356-66. PMID 20124472 DOI: 10.1158/0008-5472.Can-09-2178  0.467
2010 Schiffman JD, Hodgson JG, VandenBerg SR, Flaherty P, Polley MY, Yu M, Fisher PG, Rowitch DH, Ford JM, Berger MS, Ji H, Gutmann DH, James CD. Oncogenic BRAF mutation with CDKN2A inactivation is characteristic of a subset of pediatric malignant astrocytomas. Cancer Research. 70: 512-9. PMID 20068183 DOI: 10.1158/0008-5472.Can-09-1851  0.373
2010 Bhola P, Banerjee S, Mukherjee J, Balasubramanium A, Arun V, Karim Z, Burrell K, Croul S, Gutmann DH, Guha A. Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft. International Journal of Cancer. Journal International Du Cancer. 126: 563-71. PMID 19634141 DOI: 10.1002/Ijc.24783  0.44
2010 Mawrin C, Wolke C, Haase D, Krüger S, Firsching R, Keilhoff G, Paulus W, Gutmann DH, Lal A, Lendeckel U. Reduced activity of CD13/aminopeptidase N (APN) in aggressive meningiomas is associated with increased levels of SPARC. Brain Pathology (Zurich, Switzerland). 20: 200-10. PMID 19236378 DOI: 10.1111/J.1750-3639.2009.00267.X  0.391
2010 Widemann BC, Fisher MJ, Dombi E, Cantor A, Vinks S, Korf B, Schorry E, Gutmann D, Packer R, Weiss BD. Phase II study of the mTOR inhibitor sirolimus for nonprogressive NF1-associated plexiform neurofibromas: A Neurofibromatosis Consortium study. Journal of Clinical Oncology. 28. DOI: 10.1200/Jco.2010.28.15_Suppl.E13601  0.385
2009 Darken RS, Bogitch R, Leonard J, Perry A, McKinstry RC, Gutmann DH, Rubin JB. Brainstem glioma presenting as pruritus in children with neurofibromatosis-1. Journal of Pediatric Hematology/Oncology. 31: 972-6. PMID 19935099 DOI: 10.1097/Mph.0B013E3181B8701F  0.395
2009 Yu J, Deshmukh H, Gutmann RJ, Emnett RJ, Rodriguez FJ, Watson MA, Nagarajan R, Gutmann DH. Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma. Neurology. 73: 1526-31. PMID 19794125 DOI: 10.1212/Wnl.0B013E3181C0664A  0.398
2009 Nunley KS, Gao F, Albers AC, Bayliss SJ, Gutmann DH. Predictive value of café au lait macules at initial consultation in the diagnosis of neurofibromatosis type 1. Archives of Dermatology. 145: 883-7. PMID 19687418 DOI: 10.1001/Archdermatol.2009.169  0.321
2009 Hegedus B, Hughes FW, Garbow JR, Gianino S, Banerjee D, Kim K, Ellisman MH, Brantley MA, Gutmann DH. Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma. Journal of Neuropathology and Experimental Neurology. 68: 542-51. PMID 19525901 DOI: 10.1097/Nen.0B013E3181A3240B  0.358
2009 Dickinson PJ, Surace EI, Cambell M, Higgins RJ, Leutenegger CM, Bollen AW, LeCouteur RA, Gutmann DH. Expression of the tumor suppressor genes NF2, 4.1B, and TSLC1 in canine meningiomas. Veterinary Pathology. 46: 884-92. PMID 19429976 DOI: 10.1354/Vp.08-Vp-0251-D-Fl  0.435
2009 Albers AC, Gutmann DH. Gliomas in patients with neurofibromatosis type 1. Expert Review of Neurotherapeutics. 9: 535-9. PMID 19344304 DOI: 10.1586/Ern.09.4  0.442
2009 Tibbetts KM, Emnett RJ, Gao F, Perry A, Gutmann DH, Leonard JR. Histopathologic predictors of pilocytic astrocytoma event-free survival. Acta Neuropathologica. 117: 657-65. PMID 19271226 DOI: 10.1007/S00401-009-0506-3  0.354
2009 Yeh TH, Lee DY, Gianino SM, Gutmann DH. Microarray analyses reveal regional astrocyte heterogeneity with implications for neurofibromatosis type 1 (NF1)-regulated glial proliferation Glia. 57: 1239-1249. PMID 19191334 DOI: 10.1002/Glia.20845  0.442
2009 Williams VC, Lucas J, Babcock MA, Gutmann DH, Korf B, Maria BL. Neurofibromatosis type 1 revisited. Pediatrics. 123: 124-33. PMID 19117870 DOI: 10.1542/Peds.2007-3204  0.366
2009 Houshmandi SS, Emnett RJ, Giovannini M, Gutmann DH. The neurofibromatosis 2 protein, merlin, regulates glial cell growth in an ErbB2- and Src-dependent manner. Molecular and Cellular Biology. 29: 1472-86. PMID 19103750 DOI: 10.1128/Mcb.01392-08  0.406
2009 Gutmann DH. Modeling human brain tumors in mice Brain Pathology. 19: 108-111. PMID 19076775 DOI: 10.1111/J.1750-3639.2008.00232.X  0.329
2009 Filion C, Motoi T, Olshen AB, Laé M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y. The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene. The Journal of Pathology. 217: 83-93. PMID 18855877 DOI: 10.1002/Path.2445  0.328
2008 Daginakatte GC, Gianino SM, Zhao NW, Parsadanian AS, Gutmann DH. Increased c-Jun-NH2-kinase signaling in neurofibromatosis-1 heterozygous microglia drives microglia activation and promotes optic glioma proliferation. Cancer Research. 68: 10358-66. PMID 19074905 DOI: 10.1158/0008-5472.Can-08-2506  0.47
2008 Rodriguez FJ, Giannini C, Asmann YW, Sharma MK, Perry A, Tibbetts KM, Jenkins RB, Scheithauer BW, Anant S, Jenkins S, Eberhart CG, Sarkaria JN, Gutmann DH. Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. Journal of Neuropathology and Experimental Neurology. 67: 1194-204. PMID 19018242 DOI: 10.1097/Nen.0B013E31818Fbe1E  0.363
2008 Striedinger K, VandenBerg SR, Baia GS, McDermott MW, Gutmann DH, Lal A. The neurofibromatosis 2 tumor suppressor gene product, merlin, regulates human meningioma cell growth by signaling through YAP. Neoplasia (New York, N.Y.). 10: 1204-12. PMID 18953429 DOI: 10.1593/Neo.08642  0.439
2008 Gutmann DH. Using neurofibromatosis-1 to better understand and treat pediatric low-grade glioma Journal of Child Neurology. 23: 1186-1194. PMID 18952585 DOI: 10.1177/0883073808321061  0.358
2008 Jost SC, Ackerman JW, Garbow JR, Manwaring LP, Gutmann DH, McKinstry RC. Diffusion-weighted and dynamic contrast-enhanced imaging as markers of clinical behavior in children with optic pathway glioma Pediatric Radiology. 38: 1293-1299. PMID 18846370 DOI: 10.1007/S00247-008-1003-X  0.346
2008 Tepel M, Roerig P, Wolter M, Gutmann DH, Perry A, Reifenberger G, Riemenschneider MJ. Frequent promoter hypermethylation and transcriptional downregulation of the NDRG2 gene at 14q11.2 in primary glioblastoma. International Journal of Cancer. 123: 2080-6. PMID 18709645 DOI: 10.1002/Ijc.23705  0.369
2008 Lau YK, Murray LB, Houshmandi SS, Xu Y, Gutmann DH, Yu Q. Merlin is a potent inhibitor of glioma growth. Cancer Research. 68: 5733-42. PMID 18632626 DOI: 10.1158/0008-5472.Can-08-0190  0.477
2008 Reilly KM, Rubin JB, Gilbertson RJ, Garbow JR, Roussel MF, Gutmann DH. Rethinking brain tumors: the fourth Mouse Models of Human Cancers Consortium nervous system tumors workshop. Cancer Research. 68: 5508-11. PMID 18632599 DOI: 10.1158/0008-5472.Can-08-0703  0.423
2008 Hegedus B, Yeh TH, Lee DY, Emnett RJ, Li J, Gutmann DH. Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis. Human Molecular Genetics. 17: 2956-66. PMID 18614544 DOI: 10.1093/Hmg/Ddn194  0.367
2008 Elghazi L, Weiss AJ, Gould AP, Hegedus B, Gutmann DH, Bernal-Mizrachi E. Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination. Genesis (New York, N.Y. : 2000). 46: 256-64. PMID 18442046 DOI: 10.1002/Dvg.20388  0.324
2008 Patil S, Perry A, Maccollin M, Dong S, Betensky RA, Yeh TH, Gutmann DH, Stemmer-Rachamimov AO. Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas. Brain Pathology (Zurich, Switzerland). 18: 517-9. PMID 18422762 DOI: 10.1111/J.1750-3639.2008.00155.X  0.409
2008 Deshmukh H, Yeh TH, Yu J, Sharma MK, Perry A, Leonard JR, Watson MA, Gutmann DH, Nagarajan R. High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas. Oncogene. 27: 4745-51. PMID 18408760 DOI: 10.1038/Onc.2008.110  0.386
2008 Rodriguez FJ, Perry A, Gutmann DH, O'Neill BP, Leonard J, Bryant S, Giannini C. Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients. Journal of Neuropathology and Experimental Neurology. 67: 240-9. PMID 18344915 DOI: 10.1097/Nen.0B013E318165Eb75  0.329
2008 Hegedus B, Banerjee D, Yeh TH, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH. Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma. Cancer Research. 68: 1520-8. PMID 18316617 DOI: 10.1158/0008-5472.Can-07-5916  0.441
2008 Daginakatte GC, Gadzinski A, Emnett RJ, Stark JL, Gonzales ER, Yan P, Lee JM, Cross AH, Gutmann DH. Expression profiling identifies a molecular signature of reactive astrocytes stimulated by cyclic AMP or proinflammatory cytokines. Experimental Neurology. 210: 261-7. PMID 18054918 DOI: 10.1016/J.Expneurol.2007.10.016  0.321
2008 Gutmann DH, Bajenaru ML, Hedrick N, Wu Y, Fink L, Zhu Y, Parada L. Astrocyte-specific neurofibromatosis 1 gene deletion is insufficient for astrocytoma formation in mice Journal of Neurochemistry. 81: 2-2. DOI: 10.1046/J.1471-4159.81.S1.48_4.X  0.389
2007 Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH. Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell. 1: 443-57. PMID 18371380 DOI: 10.1016/J.Stem.2007.07.008  0.371
2007 Lee DY, Gutmann DH. Cancer stem cells and brain tumors: Uprooting the bad seeds Expert Review of Anticancer Therapy. 7: 1581-1590. PMID 18020926 DOI: 10.1586/14737140.7.11.1581  0.376
2007 Komine O, Nagaoka M, Watase K, Gutmann DH, Tanigaki K, Honjo T, Radtke F, Saito T, Chiba S, Tanaka K. The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling. Developmental Biology. 311: 238-50. PMID 17915208 DOI: 10.1016/J.Ydbio.2007.08.042  0.323
2007 Warrington NM, Woerner BM, Daginakatte GC, Dasgupta B, Perry A, Gutmann DH, Rubin JB. Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1. Cancer Research. 67: 8588-95. PMID 17875698 DOI: 10.1158/0008-5472.Can-06-2220  0.449
2007 Houshmandi SS, Gutmann DH. All in the family: using inherited cancer syndromes to understand de-regulated cell signaling in brain tumors. Journal of Cellular Biochemistry. 102: 811-9. PMID 17721931 DOI: 10.1002/Jcb.21506  0.418
2007 Spinner RJ, Scheithauer BW, Perry A, Amrami KK, Emnett R, Gutmann DH. Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. Journal of Neurosurgery. 107: 435-9. PMID 17695403 DOI: 10.3171/Jns-07/08/0435  0.368
2007 Gilbertson RJ, Gutmann DH. Tumorigenesis in the brain: Location, location, location Cancer Research. 67: 5579-5582. PMID 17575119 DOI: 10.1158/0008-5472.Can-07-0760  0.375
2007 Sandsmark DK, Zhang H, Hegedus B, Pelletier CL, Weber JD, Gutmann DH. Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes. Cancer Research. 67: 4790-9. PMID 17510408 DOI: 10.1158/0008-5472.Can-06-4470  0.761
2007 Sandsmark DK, Pelletier C, Weber JD, Gutmann DH. Mammalian target of rapamycin: master regulator of cell growth in the nervous system. Histology and Histopathology. 22: 895-903. PMID 17503347 DOI: 10.14670/Hh-22.895  0.756
2007 Daginakatte GC, Gutmann DH. Neurofibromatosis-1 (Nf1) heterozygous brain microglia elaborate paracrine factors that promote Nf1-deficient astrocyte and glioma growth. Human Molecular Genetics. 16: 1098-112. PMID 17400655 DOI: 10.1093/Hmg/Ddm059  0.477
2007 Listernick R, Ferner RE, Liu GT, Gutmann DH. Optic pathway gliomas in neurofibromatosis-1: Controversies and recommendations Annals of Neurology. 61: 189-198. PMID 17387725 DOI: 10.1002/Ana.21107  0.418
2007 Banerjee D, Hegedus B, Gutmann DH, Garbow JR. Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo. Neuroimage. 35: 1434-7. PMID 17383899 DOI: 10.1016/J.Neuroimage.2007.02.019  0.341
2007 Su W, Xing R, Guha A, Gutmann DH, Sherman LS. Mice with GFAP-targeted loss of neurofibromin demonstrate increased axonal MET expression with aging. Glia. 55: 723-33. PMID 17348023 DOI: 10.1002/Glia.20501  0.429
2007 Pelletier CL, Maggi LB, Brady SN, Scheidenhelm DK, Gutmann DH, Weber JD. TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation. Cancer Research. 67: 1609-17. PMID 17308101 DOI: 10.1158/0008-5472.Can-06-2875  0.326
2007 Sharma MK, Mansur DB, Reifenberger G, Perry A, Leonard JR, Aldape KD, Albin MG, Emnett RJ, Loeser S, Watson MA, Nagarajan R, Gutmann DH. Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin. Cancer Research. 67: 890-900. PMID 17283119 DOI: 10.1158/0008-5472.Can-06-0973  0.402
2006 Houshmandi SS, Surace EI, Zhang HB, Fuller GN, Gutmann DH. Tumor suppressor in lung cancer-1 (TSLC1) functions as a glioma tumor suppressor. Neurology. 67: 1863-6. PMID 17130425 DOI: 10.1212/01.Wnl.0000244472.56198.84  0.384
2006 Leonard JR, Perry A, Rubin JB, King AA, Chicoine MR, Gutmann DH. The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1. Neurology. 67: 1509-12. PMID 17060590 DOI: 10.1212/01.Wnl.0000240076.31298.47  0.394
2006 Wei Q, Clarke L, Scheidenhelm DK, Qian B, Tong A, Sabha N, Karim Z, Bock NA, Reti R, Swoboda R, Purev E, Lavoie JF, Bajenaru ML, Shannon P, Herlyn D, ... ... Gutmann DH, et al. High-grade glioma formation results from postnatal pten loss or mutant epidermal growth factor receptor expression in a transgenic mouse glioma model. Cancer Research. 66: 7429-37. PMID 16885338 DOI: 10.1158/0008-5472.Can-06-0712  0.389
2006 Surace EI, Strickland A, Hess RA, Gutmann DH, Naughton CK. Tslc1 (nectin-like molecule-2) is essential for spermatozoa motility and male fertility. Journal of Andrology. 27: 816-25. PMID 16837733 DOI: 10.2164/Jandrol.106.000398  0.301
2006 Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH. The neurobiology of neurooncology. Annals of Neurology. 60: 3-11. PMID 16802285 DOI: 10.1002/Ana.20912  0.406
2006 Gerber MA, Bahr SM, Gutmann DH. Protein 4.1B/differentially expressed in adenocarcinoma of the lung-1 functions as a growth suppressor in meningioma cells by activating Rac1-dependent c-Jun-NH(2)-kinase signaling. Cancer Research. 66: 5295-303. PMID 16707455 DOI: 10.1158/0008-5472.Can-05-1628  0.342
2006 Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM. Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein. Proceedings of the National Academy of Sciences of the United States of America. 103: 4463-8. PMID 16537381 DOI: 10.1073/Pnas.0510651103  0.315
2006 Miller SJ, Rangwala F, Williams J, Ackerman P, Kong S, Jegga AG, Kaiser S, Aronow BJ, Frahm S, Kluwe L, Mautner V, Upadhyaya M, Muir D, Wallace M, Hagen J, ... ... Gutmann DH, et al. Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues. Cancer Research. 66: 2584-91. PMID 16510576 DOI: 10.1158/0008-5472.Can-05-3330  0.379
2006 Gutmann DH, Maher EA, Van Dyke T. Mouse models of human cancers consortium workshop on nervous system tumors Cancer Research. 66: 10-13. PMID 16397207 DOI: 10.1158/0008-5472.Can-05-3180  0.375
2006 Mangoura D, Sun Y, Li C, Singh D, Gutmann DH, Flores A, Ahmed M, Vallianatos G. Phosphorylation of neurofibromin by PKC is a possible molecular switch in EGF receptor signaling in neural cells. Oncogene. 25: 735-45. PMID 16314845 DOI: 10.1038/Sj.Onc.1209113  0.35
2006 Yamada D, Kikuchi S, Williams YN, Sakurai-Yageta M, Masuda M, Maruyama T, Tomita K, Gutmann DH, Kakizoe T, Kitamura T, Kanai Y, Murakami Y. Promoter hypermethylation of the potential tumor suppressor DAL-1/4.1B gene in renal clear cell carcinoma. International Journal of Cancer. Journal International Du Cancer. 118: 916-23. PMID 16152585 DOI: 10.1002/Ijc.21450  0.331
2006 Esper GJ, Gutmann DH. Neurofibromatosis 1 and 2 Principles of Molecular Medicine. 1160-1164. DOI: 10.1007/978-1-59259-963-9_121  0.311
2005 Jansen LA, Uhlmann EJ, Crino PB, Gutmann DH, Wong M. Epileptogenesis and reduced inward rectifier potassium current in tuberous sclerosis complex-1-deficient astrocytes. Epilepsia. 46: 1871-80. PMID 16393152 DOI: 10.1111/J.1528-1167.2005.00289.X  0.311
2005 Mawrin C, Schulz S, Hellwig-Patyk A, Kirches E, Roessner A, Lendeckel U, Firsching R, Vorwerk CK, Keilhoff G, Dietzmann K, Grimm K, Lindberg G, Gutmann DH, Scheithauer BW, Perry A. Expression and function of somatostatin receptors in peripheral nerve sheath tumors. Journal of Neuropathology and Experimental Neurology. 64: 1080-8. PMID 16319718 DOI: 10.1097/01.Jnen.0000190065.36182.25  0.364
2005 Zhu Y, Harada T, Liu L, Lush ME, Guignard F, Harada C, Burns DK, Bajenaru ML, Gutmann DH, Parada LF. Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation. Development (Cambridge, England). 132: 5577-88. PMID 16314489 DOI: 10.1242/Dev.02162  0.437
2005 Dasgupta B, Yi Y, Hegedus B, Weber JD, Gutmann DH. Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma. Cancer Research. 65: 9843-50. PMID 16267007 DOI: 10.1158/0008-5472.Can-05-1842  0.481
2005 Sharma MK, Zehnbauer BA, Watson MA, Gutmann DH. RAS pathway activation and an oncogenic RAS mutation in sporadic pilocytic astrocytoma. Neurology. 65: 1335-6. PMID 16247081 DOI: 10.1212/01.Wnl.0000180409.78098.D7  0.382
2005 Shannon P, Sabha N, Lau N, Kamnasaran D, Gutmann DH, Guha A. Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. The American Journal of Pathology. 167: 859-67. PMID 16127163 DOI: 10.1016/S0002-9440(10)62057-3  0.304
2005 Lusis EA, Watson MA, Chicoine MR, Lyman M, Roerig P, Reifenberger G, Gutmann DH, Perry A. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Research. 65: 7121-6. PMID 16103061 DOI: 10.1158/0008-5472.Can-05-0043  0.379
2005 Scoles DR, Qin Y, Nguyen V, Gutmann DH, Pulst SM. HRS inhibits EGF receptor signaling in the RT4 rat schwannoma cell line. Biochemical and Biophysical Research Communications. 335: 385-92. PMID 16083858 DOI: 10.1016/J.Bbrc.2005.07.083  0.31
2005 Rubin JB, Gutmann DH. Neurofibromatosis type 1 - a model for nervous system tumour formation? Nature Reviews. Cancer. 5: 557-64. PMID 16069817 DOI: 10.1038/Nrc1653  0.364
2005 Kuns R, Kissil JL, Newsham IF, Jacks T, Gutmann DH, Sherman LS. Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation. Oncogene. 24: 6502-15. PMID 16007173 DOI: 10.1038/Sj.Onc.1208813  0.322
2005 Yang G, Khalaf W, van de Locht L, Jansen JH, Gao M, Thompson MA, van der Reijden BA, Gutmann DH, Delwel R, Clapp DW, Hiebert SW. Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein. Molecular and Cellular Biology. 25: 5869-79. PMID 15988004 DOI: 10.1128/Mcb.25.14.5869-5879.2005  0.414
2005 Dasgupta B, Gutmann DH. Neurofibromin regulates neural stem cell proliferation, survival, and astroglial differentiation in vitro and in vivo Journal of Neuroscience. 25: 5584-5594. PMID 15944386 DOI: 10.1523/Jneurosci.4693-04.2005  0.455
2005 Perry A, Lusis EA, Gutmann DH. Meningothelial hyperplasia: A detailed clinicopathologic, immunohistochemical and genetic study of 11 cases Brain Pathology. 15: 109-115. PMID 15912882 DOI: 10.1111/J.1750-3639.2005.Tb00505.X  0.336
2005 Ess KC, Kamp CA, Tu BP, Gutmann DH. Developmental origin of subependymal giant cell astrocytoma in tuberous sclerosis complex. Neurology. 64: 1446-9. PMID 15851742 DOI: 10.1212/01.Wnl.0000158653.81008.49  0.371
2005 Dasgupta B, Yi Y, Chen DY, Weber JD, Gutmann DH. Proteomic analysis reveals hyperactivation of the mammalian target of rapamycin pathway in neurofibromatosis 1-associated human and mouse brain tumors. Cancer Research. 65: 2755-60. PMID 15805275 DOI: 10.1158/0008-5472.Can-04-4058  0.472
2005 Scheidenhelm DK, Cresswell J, Haipek CA, Fleming TP, Mercer RW, Gutmann DH. Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. Molecular and Cellular Biology. 25: 3151-62. PMID 15798201 DOI: 10.1128/Mcb.25.8.3151-3162.2005  0.334
2005 Ward BA, Gutmann DH. Neurofibromatosis 1: From lab bench to clinic Pediatric Neurology. 32: 221-228. PMID 15797177 DOI: 10.1016/J.Pediatrneurol.2004.11.002  0.399
2005 Perry A, Kurtkaya-Yapicier O, Scheithauer BW, Robinson S, Prayson RA, Kleinschmidt-DeMasters BK, Stemmer-Rachamimov AO, Gutmann DH. Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature. Brain Pathology (Zurich, Switzerland). 15: 55-65. PMID 15779237 DOI: 10.1111/J.1750-3639.2005.Tb00100.X  0.329
2005 Rajaram V, Gutmann DH, Prasad SK, Mansur DB, Perry A. Alterations of protein 4.1 family members in ependymomas: a study of 84 cases. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 18: 991-7. PMID 15731777 DOI: 10.1038/Modpathol.3800390  0.349
2005 Kabbarah O, Sotelo AK, Mallon MA, Winkeler EL, Fan MY, Pfeifer JD, Shibata D, Gutmann DH, Goodfellow PJ. Diethylstilbestrol effects and lymphomagenesis in Mlh1-deficient mice. International Journal of Cancer. Journal International Du Cancer. 115: 666-9. PMID 15700306 DOI: 10.1002/Ijc.20918  0.301
2005 Robb VA, Gerber MA, Hart-Mahon EK, Gutmann DH. Membrane localization of the U2 domain of Protein 4.1B is necessary and sufficient for meningioma growth suppression. Oncogene. 24: 1946-57. PMID 15688033 DOI: 10.1038/Sj.Onc.1208335  0.3
2005 Bajenaru ML, Garbow JR, Perry A, Hernandez MR, Gutmann DH. Natural history of neurofibromatosis 1-associated optic nerve glioma in mice Annals of Neurology. 57: 119-127. PMID 15622533 DOI: 10.1002/Ana.20337  0.406
2005 Listernick R, Ferner RE, Piersall L, Sharif S, Gutmann DH, Charrow J. Late-onset optic pathway tumors in children with neurofibromatosis 1. Neurology. 63: 1944-6. PMID 15557519 DOI: 10.1212/01.Wnl.0000144341.16830.01  0.395
2004 Perry A, Gutmann DH, Reifenberger G. Molecular pathogenesis of meningiomas Journal of Neuro-Oncology. 70: 183-202. PMID 15674477 DOI: 10.1007/S11060-004-2749-0  0.388
2004 Rong R, Tang X, Gutmann DH, Ye K. Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L. Proceedings of the National Academy of Sciences of the United States of America. 101: 18200-5. PMID 15598747 DOI: 10.1073/Pnas.0405971102  0.308
2004 Scheidenhelm DK, Gutmann DH. Mouse models of tuberous sclerosis complex Journal of Child Neurology. 19: 726-733. PMID 15563020 DOI: 10.1177/08830738040190091401  0.355
2004 Lusis E, Gutmann DH. Meningioma: An update Current Opinion in Neurology. 17: 687-692. PMID 15542977 DOI: 10.1097/00019052-200412000-00008  0.398
2004 Surace EI, Lusis E, Murakami Y, Scheithauer BW, Perry A, Gutmann DH. Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival. Journal of Neuropathology and Experimental Neurology. 63: 1015-27. PMID 15535129 DOI: 10.1093/Jnen/63.10.1015  0.4
2004 Fraser MM, Zhu X, Kwon CH, Uhlmann EJ, Gutmann DH, Baker SJ. Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Research. 64: 7773-9. PMID 15520182 DOI: 10.1158/0008-5472.Can-04-2487  0.407
2004 Watson MA, Perry A, Tihan T, Prayson RA, Guha A, Bridge J, Ferner R, Gutmann DH. Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors. Brain Pathology (Zurich, Switzerland). 14: 297-303. PMID 15446585 DOI: 10.1111/J.1750-3639.2004.Tb00067.X  0.444
2004 Rong R, Surace EI, Haipek CA, Gutmann DH, Ye K. Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene. 23: 8447-54. PMID 15378014 DOI: 10.1038/Sj.Onc.1207794  0.332
2004 Fedi M, Anne Mitchell L, Kalnins RM, Gutmann DH, Perry A, Newton M, Brodtmann A, Berkovic SF. Glioneuronal tumours in neurofibromatosis type 1: MRI-pathological study. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 11: 745-7. PMID 15337138 DOI: 10.1016/J.Jocn.2003.10.017  0.37
2004 Singh V, Miranda TB, Jiang W, Frankel A, Roemer ME, Robb VA, Gutmann DH, Herschman HR, Clarke S, Newsham IF. DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo. Oncogene. 23: 7761-71. PMID 15334060 DOI: 10.1038/Sj.Onc.1208057  0.304
2004 Surace EI, Lusis E, Haipek CA, Gutmann DH. Functional significance of S6K overexpression in meningioma progression Annals of Neurology. 56: 295-298. PMID 15293284 DOI: 10.1002/Ana.20201  0.4
2004 Uhlmann EJ, Li W, Scheidenhelm DK, Gau CL, Tamanoi F, Gutmann DH. Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation. Glia. 47: 180-8. PMID 15185396 DOI: 10.1002/Glia.20036  0.362
2004 Robb VA, Li W, Gutmann DH. Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression Oncogene. 23: 3589-3596. PMID 15116094 DOI: 10.1038/Sj.Onc.1207445  0.36
2004 Arun D, Gutmann DH. Recent advances in neurofibromatosis type 1 Current Opinion in Neurology. 17: 101-105. PMID 15021234 DOI: 10.1097/00019052-200404000-00004  0.482
2004 Ess KC, Uhlmann EJ, Li W, Li H, Declue JE, Crino PB, Gutmann DH. Expression profiling in tuberous sclerosis complex (TSC) knockout mouse astrocytes to characterize human TSC brain pathology. Glia. 46: 28-40. PMID 14999811 DOI: 10.1002/Glia.10324  0.375
2004 Chen Y, Gutmann DH, Haipek CA, Martinsen BJ, Bronner-Fraser M, Krull CE. Characterization of chicken Nf2/merlin indicates regulatory roles in cell proliferation and migration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 229: 541-54. PMID 14991710 DOI: 10.1002/Dvdy.20002  0.363
2004 Su W, Gutmann DH, Perry A, Abounader R, Laterra J, Sherman LS. CD44-independent hepatocyte growth factor/c-Met autocrine loop promotes malignant peripheral nerve sheath tumor cell invasion in vitro. Glia. 45: 297-306. PMID 14730703 DOI: 10.1002/Glia.10340  0.331
2004 Surace EI, Haipek CA, Gutmann DH. Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function Oncogene. 23: 580-587. PMID 14724586 DOI: 10.1038/Sj.Onc.1207142  0.372
2003 Bajenaru ML, Hernandez MR, Perry A, Zhu Y, Parada LF, Garbow JR, Gutmann DH. Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity. Cancer Research. 63: 8573-7. PMID 14695164  0.313
2003 Gutmann DH, James CD, Poyhonen M, Louis DN, Ferner R, Guha A, Hariharan S, Viskochil D, Perry A. Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1. Neurology. 61: 1397-400. PMID 14638962 DOI: 10.1212/Wnl.61.10.1397  0.426
2003 Oh MK, Scoles DR, Haipek C, Strand AD, Gutmann DH, Olson JM, Pulst SM. Genetic heterogeneity of stably transfected cell lines revealed by expression profiling with oligonucleotide microarrays. Journal of Cellular Biochemistry. 90: 1068-78. PMID 14624465 DOI: 10.1002/Jcb.10712  0.301
2003 Maldonado M, Baybis M, Newman D, Kolson DL, Chen W, McKhann G, Gutmann DH, Crino PB. Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiology of Disease. 14: 279-90. PMID 14572449 DOI: 10.1016/S0969-9961(03)00127-X  0.364
2003 Dasgupta B, Dugan LL, Gutmann DH. The neurofibromatosis 1 gene product neurofibromin regulates pituitary adenylate cyclase-activating polypeptide-mediated signaling in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8949-54. PMID 14523097 DOI: 10.1523/Jneurosci.23-26-08949.2003  0.426
2003 King A, Listernick R, Charrow J, Piersall L, Gutmann DH. Optic pathway gliomas in neurofibromatosis type 1: The effect of presenting symptoms on outcome American Journal of Medical Genetics. 122: 95-99. PMID 12955759 DOI: 10.1002/Ajmg.A.20211  0.362
2003 Robb VA, Li W, Gascard P, Perry A, Mohandas N, Gutmann DH. Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis. Neurobiology of Disease. 13: 191-202. PMID 12901833 DOI: 10.1016/S0969-9961(03)00071-8  0.335
2003 Gutmann DH, Winkeler E, Kabbarah O, Hedrick N, Dudley S, Goodfellow PJ, Liskay RM. Mlh1 deficiency accelerates myeloid leukemogenesis in neurofibromatosis 1 (Nf1) heterozygous mice. Oncogene. 22: 4581-5. PMID 12881715 DOI: 10.1038/Sj.Onc.1206768  0.372
2003 Tabancay AP, Gau CL, Machado IM, Uhlmann EJ, Gutmann DH, Guo L, Tamanoi F. Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K. The Journal of Biological Chemistry. 278: 39921-30. PMID 12869548 DOI: 10.1074/Jbc.M306553200  0.341
2003 Apicelli AJ, Uhlmann EJ, Baldwin RL, Ding H, Nagy A, Guha A, Gutmann DH. Role of the Rap1 GTPase in astrocyte growth regulation. Glia. 42: 225-34. PMID 12673829 DOI: 10.1002/Glia.10214  0.372
2003 Dasgupta B, Gutmann DH. Neurofibromatosis 1: Closing the GAP between mice and men Current Opinion in Genetics and Development. 13: 20-27. PMID 12573431 DOI: 10.1016/S0959-437X(02)00015-1  0.465
2003 Huang Zy, Wu Y, Hedrick N, Gutmann DH. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21CIP1/WAF1 expression Molecular and Cellular Biology. 23: 566-578. PMID 12509455 DOI: 10.1128/Mcb.23.2.566-578.2003  0.304
2003 Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH, Guha A. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. International Journal of Oncology. 22: 195-200. PMID 12469204  0.301
2003 Lau N, Uhlmann EJ, Lintig FCV, Nagy A, Boss GR, Gutmann DH, Guha A. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression International Journal of Oncology. 22: 195-200. DOI: 10.3892/Ijo.22.1.195  0.416
2002 Scoles DR, Nguyen VD, Qin Y, Sun CX, Morrison H, Gutmann DH, Pulst SM. Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Human Molecular Genetics. 11: 3179-89. PMID 12444102 DOI: 10.1093/Hmg/11.25.3179  0.39
2002 Sun CX, Haipek C, Scoles DR, Pulst SM, Giovannini M, Komada M, Gutmann DH. Functional analysis of the relationship between the neurofibromatosis 2 tumor suppressor and its binding partner, hepatocyte growth factor-regulated tyrosine kinase substrate. Human Molecular Genetics. 11: 3167-78. PMID 12444101 DOI: 10.1093/Hmg/11.25.3167  0.373
2002 Lynch TM, Gutmann DH. Neurofibromatosis 1. Neurologic Clinics. 20: 841-65. PMID 12432832  0.31
2002 Gutmann DH. Neurofibromin in the brain Journal of Child Neurology. 17: 592-601. PMID 12403558 DOI: 10.1177/088307380201700809  0.401
2002 Woods SA, Marmor E, Feldkamp M, Lau N, Apicelli AJ, Boss G, Gutmann DH, Guha A. Aberrant G protein signaling in nervous system tumors. Journal of Neurosurgery. 97: 627-42. PMID 12296648 DOI: 10.3171/Jns.2002.97.3.0627  0.335
2002 Gutmann DH, Rasmussen SA, Wolkenstein P, MacCollin MM, Guha A, Inskip PD, North KN, Poyhonen M, Birch PH, Friedman JM. Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1). Neurology. 59: 759-61. PMID 12221173 DOI: 10.1212/Wnl.59.5.759  0.423
2002 Chan CC, Koch CA, Kaiser-Kupfer MI, Parry DM, Gutmann DH, Zhuang Z, Vortmeyer AO. Loss of heterozygosity for the NF2 gene in retinal and optic nerve lesions of patients with neurofibromatosis 2. The Journal of Pathology. 198: 14-20. PMID 12210058 DOI: 10.1002/Path.1174  0.306
2002 Friedman JM, Arbiter J, Epstein JA, Gutmann DH, Huot SJ, Lin AE, McManus B, Korf BR. Cardiovascular disease in neurofibromatosis 1: Report of the NF1 Cardiovascular Task Force Genetics in Medicine. 4: 105-111. PMID 12180143 DOI: 10.1097/00125817-200205000-00002  0.306
2002 Watson MA, Gutmann DH, Peterson K, Chicoine MR, Kleinschmidt-DeMasters BK, Brown HG, Perry A. Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays. The American Journal of Pathology. 161: 665-72. PMID 12163391 DOI: 10.1016/S0002-9440(10)64222-8  0.385
2002 Perry A, Kunz SN, Fuller CE, Banerjee R, Marley EF, Liapis H, Watson MA, Gutmann DH. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. Journal of Neuropathology and Experimental Neurology. 61: 702-9. PMID 12152785 DOI: 10.1093/Jnen/61.8.702  0.354
2002 Baser ME, De Rienzo A, Altomare D, Balsara BR, Hedrick NM, Gutmann DH, Pitts LH, Jackler RK, Testa JR. Neurofibromatosis 2 and malignant mesothelioma. Neurology. 59: 290-1. PMID 12136076 DOI: 10.1212/Wnl.59.2.290  0.412
2002 Gutmann DH, Giovannini M. Mouse models of neurofibromatosis 1 and 2 Neoplasia. 4: 279-290. PMID 12082543 DOI: 10.1038/Sj.Neo.7900249  0.457
2002 Bajenaru ML, Zhu Y, Hedrick NM, Donahoe J, Parada LF, Gutmann DH. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Molecular and Cellular Biology. 22: 5100-13. PMID 12077339 DOI: 10.1128/Mcb.22.14.5100-5113.2002  0.438
2002 Packer RJ, Gutmann DH, Rubenstein A, Viskochil D, Zimmerman RA, Vezina G, Small J, Korf B. Plexiform neurofibromas in NF1: toward biologic-based therapy. Neurology. 58: 1461-70. PMID 12041525 DOI: 10.1212/Wnl.58.10.1461  0.438
2002 Uhlmann EJ, Apicelli AJ, Baldwin RL, Burke SP, Bajenaru ML, Onda H, Kwiatkowski D, Gutmann DH. Heterozygosity for the tuberous sclerosis complex (TSC) gene products results in increased astrocyte numbers and decreased p27-Kip1 expression in TSC2+/- cells. Oncogene. 21: 4050-9. PMID 12037687 DOI: 10.1038/Sj.Onc.1205435  0.406
2002 Singh PK, Gutmann DH, Fuller CE, Newsham IF, Perry A. Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomas. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 15: 526-31. PMID 12011257 DOI: 10.1038/Modpathol.3880558  0.397
2002 Kalamarides M, Niwa-Kawakita M, Leblois H, Abramowski V, Perricaudet M, Janin A, Thomas G, Gutmann DH, Giovannini M. Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse. Genes & Development. 16: 1060-5. PMID 12000789 DOI: 10.1101/Gad.226302  0.446
2002 Ferner RE, Gutmann DH. International consensus statement on malignant peripheral nerve sheath tumors in neurofibromatosis Cancer Research. 62: 1573-1577. PMID 11894862  0.301
2002 Gutmann DH, Huang ZY, Hedrick NM, Ding H, Guha A, Watson MA. Mouse glioma gene expression profiling identifies novel human glioma-associated genes. Annals of Neurology. 51: 393-405. PMID 11891838 DOI: 10.1002/Ana.10145  0.382
2002 Huang ZY, Baldwin RL, Hedrick NM, Gutmann DH. Astrocyte-specific expression of CDK4 is not sufficient for tumor formation, but cooperates with p53 heterozygosity to provide a growth advantage for astrocytes in vivo. Oncogene. 21: 1325-34. PMID 11857076 DOI: 10.1038/Sj.Onc.1205206  0.39
2002 Sun CX, Robb VA, Gutmann DH. Protein 4.1 tumor suppressors: Getting a FERM grip on growth regulation Journal of Cell Science. 115: 3991-4000. DOI: 10.1242/Jcs.00094  0.389
2001 Gutmann DH, Wu YL, Hedrick NM, Zhu Y, Guha A, Parada LF. Heterozygosity for the neurofibromatosis 1 (NF1) tumor suppressor results in abnormalities in cell attachment, spreading and motility in astrocytes. Human Molecular Genetics. 10: 3009-16. PMID 11751683 DOI: 10.1093/Hmg/10.26.3009  0.476
2001 Sherman LS, Gutmann DH. Merlin: hanging tumor suppression on the Rac. Trends in Cell Biology. 11: 442-4. PMID 11684412 DOI: 10.1016/S0962-8924(01)02128-6  0.414
2001 Perry A, Giannini C, Raghavan R, Scheithauer BW, Banerjee R, Margraf L, Bowers DC, Lytle RA, Newsham IF, Gutmann DH. Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases. Journal of Neuropathology and Experimental Neurology. 60: 994-1003. PMID 11589430 DOI: 10.1093/Jnen/60.10.994  0.391
2001 Arbiser JL, Yeung R, Weiss SW, Arbiser ZK, Amin MB, Cohen C, Frank D, Mahajan S, Herron GS, Yang J, Onda H, Zhang HB, Bai X, Uhlmann E, Loehr A, ... ... Gutmann DH, et al. The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: Use of telomerase to obtain stable populations of cells from benign neoplasms American Journal of Pathology. 159: 483-491. PMID 11485907 DOI: 10.1016/S0002-9440(10)61720-8  0.302
2001 Listernick R, Charrow J, Gutmann DH. Comments on neurofibromatosis 1 and optic pathway tumors [1] American Journal of Medical Genetics. 102: 105. PMID 11471182 DOI: 10.1002/1096-8628(20010722)102:1<105::Aid-Ajmg1395>3.0.Co;2-C  0.345
2001 Gutmann DH, Hirbe AC, Haipek CA. Functional analysis of neurofibromatosis 2 (NF2) missense mutations Human Molecular Genetics. 10: 1519-1529. PMID 11448944 DOI: 10.1093/Hmg/10.14.1519  0.443
2001 Scherer SS, Xu T, Crino P, Arroyo EJ, Gutmann DH. Ezrin, radixin, and moesin are components of Schwann cell microvilli. Journal of Neuroscience Research. 65: 150-64. PMID 11438984 DOI: 10.1002/Jnr.1138  0.348
2001 Perry A, Roth KA, Banerjee R, Fuller CE, Gutmann DH. NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors. The American Journal of Pathology. 159: 57-61. PMID 11438454 DOI: 10.1016/S0002-9440(10)61673-2  0.442
2001 MacCollin M, Gutmann DH, Korf B, Finkelstein R. Establishing priorities in neurofibromatosis research: A workshop summary Genetics in Medicine. 3: 212-217. PMID 11388764 DOI: 10.1097/00125817-200105000-00012  0.355
2001 Morrison H, Sherman LS, Legg J, Banine F, Isacke C, Haipek CA, Gutmann DH, Ponta H, Herrlich P. The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44. Genes & Development. 15: 968-80. PMID 11316791 DOI: 10.1101/Gad.189601  0.339
2001 Gutmann DH, Hirbe AC, Huang ZY, Haipek CA. The Protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion Neurobiology of Disease. 8: 266-278. PMID 11300722 DOI: 10.1006/Nbdi.2000.0376  0.41
2001 Li J, Perry A, James CD, Gutmann DH. Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas Neurology. 56: 885-890. PMID 11294925 DOI: 10.1212/Wnl.56.7.885  0.437
2001 Reed N, Gutmann DH. Tumorigenesis in neurofibromatosis: New insights and potential therapies Trends in Molecular Medicine. 7: 157-162. PMID 11286939 DOI: 10.1016/S1471-4914(01)01955-4  0.466
2001 Gutmann DH, Haipek CA, Burke SP, Sun CX, Scoles DR, Pulst SM. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility. Human Molecular Genetics. 10: 825-34. PMID 11285248 DOI: 10.1093/Hmg/10.8.825  0.321
2001 Gutmann DH. The neurofibromatoses: When less is more Human Molecular Genetics. 10: 747-755. PMID 11257108 DOI: 10.1093/Hmg/10.7.747  0.473
2001 Bajenaru ML, Donahoe J, Corral T, Reilly KM, Brophy S, Pellicer A, Gutmann DH. Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes. Glia. 33: 314-23. PMID 11246230 DOI: 10.1002/1098-1136(20010315)33:4<314::Aid-Glia1030>3.0.Co;2-Q  0.413
2001 Uhlmann EJ, Gutmann DH. Tumor suppressor gene regulation of cell growth: Recent insights into neurofibromatosis 1 and 2 gene function Cell Biochemistry and Biophysics. 34: 61-78. DOI: 10.1385/Cbb:34:1:61  0.39
2000 Perry A, Cai DX, Scheithauer BW, Swanson PE, Lohse CM, Newsham IF, Weaver A, Gutmann DH. Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases. Journal of Neuropathology and Experimental Neurology. 59: 872-9. PMID 11079777 DOI: 10.1093/Jnen/59.10.872  0.403
2000 Lau N, Feldkamp MM, Roncari L, Loehr AH, Shannon P, Gutmann DH, Guha A. Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. Journal of Neuropathology and Experimental Neurology. 59: 759-67. PMID 11005256 DOI: 10.1093/Jnen/59.9.759  0.426
2000 Lim DJ, Rubenstein AE, Evans DG, Jacks T, Seizinger BG, Baser ME, Beebe D, Brackmann DE, Chiocca EA, Fehon RG, Giovannini M, Glazer R, Gusella JF, Gutmann DH, Korf B, et al. Advances in neurofibromatosis 2 (NF2): a workshop report. Journal of Neurogenetics. 14: 63-106. PMID 10992163 DOI: 10.3109/01677060009083477  0.338
2000 King AA, Debaun MR, Riccardi VM, Gutmann DH. Malignant peripheral nerve sheath tumors in neurofibromatosis 1 American Journal of Medical Genetics. 93: 388-392. PMID 10951462 DOI: 10.1002/1096-8628(20000828)93:5<388::Aid-Ajmg8>3.0.Co;2-#  0.35
2000 Gutmann DH, Donahoe J, Brown T, James CD, Perry A. Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas Neuropathology and Applied Neurobiology. 26: 361-367. PMID 10931370 DOI: 10.1046/J.1365-2990.2000.00258.X  0.401
2000 Gutmann DH, Donahoe J, Perry A, Lemke N, Gorse K, Kittiniyom K, Rempel SA, Gutierrez JA, Newsham IF. Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas. Human Molecular Genetics. 9: 1495-500. PMID 10888600 DOI: 10.1093/Hmg/9.10.1495  0.418
2000 Scoles DR, Huynh DP, Chen MS, Burke SP, Gutmann DH, Pulst SM. The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate. Human Molecular Genetics. 9: 1567-74. PMID 10861283 DOI: 10.1093/Hmg/9.11.1567  0.357
2000 Waggoner DJ, Towbin J, Gottesman G, Gutmann DH. Clinic-based study of plexiform neurofibromas in neurofibromatosis 1 American Journal of Medical Genetics. 92: 132-135. PMID 10797438 DOI: 10.1002/(Sici)1096-8628(20000515)92:2<132::Aid-Ajmg10>3.0.Co;2-6  0.427
2000 Rutkowski JL, Wu K, Gutmann DH, Boyer PJ, Legius E. Genetic and cellular defects contributing to benign tumor formation in neurofibromatosis type 1. Human Molecular Genetics. 9: 1059-66. PMID 10767330 DOI: 10.1093/Hmg/9.7.1059  0.47
2000 Gutmann DH, Zhang Y, Hasbani MJ, Goldberg MP, Plank TL, Henske EP. Expression of the tuberous sclerosis complex gene products, hamartin and tuberin, in central nervous system tissues Acta Neuropathologica. 99: 223-230. PMID 10663963 DOI: 10.1007/Pl00007431  0.317
2000 King A, Gutmann DH. The question of familial meningiomas and schwannomas: NF2B or not to be? Neurology. 54: 4-5. PMID 10636116 DOI: 10.1212/Wnl.54.1.4  0.358
2000 Ding H, Nagy A, Gutmann DH, Guha A. A review of astrocytoma models Neurosurgical Focus. 8: 1-8. DOI: 10.3171/Foc.2000.8.4.2  0.363
2000 Guha A, Ding H, Macmaster S, Roncari L, Wu X, Lau N, Shannon P, Gutmann D, Nagy A. 764 Transgenic Mouse Model of Malignant Astrocytoma: Specific Astrocyte Specific Expression of Activated RAS Neurosurgery. 47: 518-518. DOI: 10.1097/00006123-200008000-00112  0.307
1999 Gutmann DH, Zhang Y, Hirbe A. Developmental regulation of a neuron-specific neurofibromatosis 1 isoform Annals of Neurology. 46: 777-782. PMID 10553997 DOI: 10.1002/1531-8249(199911)46:5<777::Aid-Ana15>3.0.Co;2-H  0.313
1999 Liapis H, Dehner LP, Gutmann DH. Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. The American Journal of Surgical Pathology. 23: 1156-8. PMID 10478679 DOI: 10.1097/00000478-199909000-00024  0.353
1999 Listernick R, Charrow J, Gutmann DH. Intracranial gliomas in neurofibromatosis type 1 American Journal of Medical Genetics - Seminars in Medical Genetics. 89: 38-44. PMID 10469435 DOI: 10.1002/(Sici)1096-8628(19990326)89:1<38::Aid-Ajmg8>3.0.Co;2-M  0.413
1999 Strauss BL, Gutmann DH, Dehner LP, Hirbe A, Zhu X, Marley EF, Liapis H. Molecular analysis of malignant triton tumors. Human Pathology. 30: 984-8. PMID 10452514 DOI: 10.1016/S0046-8177(99)90255-1  0.454
1999 Gutmann DH, Loehr A, Zhang Y, Kim J, Henkemeyer M, Cashen A. Haploinsufficiency for the neurofibromatosis 1 (NF1) tumor suppressor results in increased astrocyte proliferation. Oncogene. 18: 4450-9. PMID 10442636 DOI: 10.1038/Sj.Onc.1202829  0.43
1999 Hung G, Faudoa R, Li X, Xeu Z, Brackmann DE, Hitselberg W, Saleh E, Lee F, Gutmann DH, Slattery W, Rhim JS, Lim D. Establishment of primary vestibular schwannoma cultures from neurofibromatosis type-2 patients. International Journal of Oncology. 14: 409-15. PMID 10024671 DOI: 10.3892/Ijo.14.3.409  0.367
1999 Gutmann DH, Sherman L, Seftor L, Haipek C, Hoang Lu K, Hendrix M. Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesionand spreading. Human Molecular Genetics. 8: 267-75. PMID 9931334 DOI: 10.1093/Hmg/8.2.267  0.419
1998 Gutmann DH. Parallels between tuberous sclerosis complex and neurofibromatosis 1: Common threads in the same tapestry Seminars in Pediatric Neurology. 5: 276-286. PMID 9874855 DOI: 10.1016/S1071-9091(98)80006-5  0.402
1998 Feldkamp MM, Gutmann DH, Guha A. Neurofibromatosis type 1: piecing the puzzle together. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 25: 181-91. PMID 9706718 DOI: 10.1017/S0317167100033990  0.396
1998 Gutmann DH. Recent insights into neurofibromatosis type 1: Clear genetic progress Archives of Neurology. 55: 778-780. PMID 9626767 DOI: 10.1001/Archneur.55.6.778  0.39
1998 Gutmann DH, Geist RT, Xu Hm, Kim JS, Saporito-Irwin S. Defects in neurofibromatosis 2 protein function can arise at multiple levels. Human Molecular Genetics. 7: 335-45. PMID 9466988 DOI: 10.1093/Hmg/7.3.335  0.352
1997 Sherman L, Xu HM, Geist RT, Saporito-Irwin S, Howells N, Ponta H, Herrlich P, Gutmann DH. Interdomain binding mediates tumor growth suppression by the NF2 gene product. Oncogene. 15: 2505-9. PMID 9395247 DOI: 10.1038/Sj.Onc.1201418  0.462
1997 Gutmann DH, Saporito-Irwin S, DeClue JE, Wienecke R, Guha A. Alterations in the rap1 signaling pathway are common in human gliomas. Oncogene. 15: 1611-6. PMID 9380414 DOI: 10.1038/Sj.Onc.1201314  0.42
1997 Wienecke R, Guha A, Maize JC, Heideman RL, DeClue JE, Gutmann DH. Reduced TSC2 RNA and protein in sporadic astrocytomas and ependymomas. Annals of Neurology. 42: 230-5. PMID 9266734 DOI: 10.1002/Ana.410420215  0.385
1997 Gutmann DH, Giordano MJ, Fishback AS, Guha A. Loss of merlin expression in sporadic meningiomas, ependymomas and schwannomas Neurology. 49: 267-270. PMID 9222206 DOI: 10.1212/Wnl.49.1.267  0.41
1997 Listernick R, Louis DN, Packer RJ, Gutmann DH. Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 Optic Pathway Glioma Task Force. Annals of Neurology. 41: 143-9. PMID 9029062 DOI: 10.1016/S0002-9394(14)70811-6  0.306
1997 Guha A, Lau N, Gutmann D, Pawson A, Boss G. RAS-GTP levels are elevated in human NF1 peripheral nerve tumors Clinical Neurology and Neurosurgery. 99. DOI: 10.1016/S0303-8467(97)81805-7  0.351
1996 Geist RT, Reddy AJ, Zhang J, Gutmann DH. Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues. Neurobiology of Disease. 3: 111-20. PMID 9173918 DOI: 10.1006/Nbdi.1996.0011  0.333
1996 Scherer SS, Gutmann DH. Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells. Journal of Neuroscience Research. 46: 595-605. PMID 8951671 DOI: 10.1002/(Sici)1097-4547(19961201)46:5<595::Aid-Jnr8>3.0.Co;2-E  0.388
1996 Gutmann DH, Gurney JG, Shannon KM, Zvulunov A. Juvenile xanthogranuloma, neurofibromatosis 1, and juvenile chronic myeloid leukemia [4] Archives of Dermatology. 132: 1390-1391. PMID 8915325 DOI: 10.1001/Archderm.132.11.1390  0.314
1996 Geist RT, Gutmann DH. Expression of a developmentally-regulated neuron-specific isoform of the neurofibromatosis 1 (NF1) gene Neuroscience Letters. 211: 85-88. PMID 8830850 DOI: 10.1016/0304-3940(96)12730-0  0.373
1996 Giordano MJ, Mahadeo DK, He YY, Geist RT, Hsu C, Gutmann DH. Increased expression of the neurofibromatosis 1 (NF1) gene product, neurofibromin, in astrocytes in response to cerebral ischemia. Journal of Neuroscience Research. 43: 246-53. PMID 8820972 DOI: 10.1002/(Sici)1097-4547(19960115)43:2<246::Aid-Jnr12>3.0.Co;2-4  0.424
1996 Norton KK, Mahadeo DK, Geist RT, Gutmann DH. Expression of the neurofibromatosis 1 (NF1) gene during growth arrest. Neuroreport. 7: 601-4. PMID 8730839 DOI: 10.1097/00001756-199601310-00054  0.368
1996 Platten M, Giordano MJ, Dirven CM, Gutmann DH, Louis DN. Up-regulation of specific NF 1 gene transcripts in sporadic pilocytic astrocytomas. The American Journal of Pathology. 149: 621-7. PMID 8702000  0.332
1996 Feldkamp MM, Lau N, Provias JP, Gutmann DH, Guha A. Acute presentation of a neurogenic sarcoma in a patient with neurofibromatosis type 1: a pathological and molecular explanation. Case report. Journal of Neurosurgery. 84: 867-73. PMID 8622163 DOI: 10.3171/Jns.1996.84.5.0867  0.417
1995 Norton KK, Xu J, Gutmann DH. Expression of the neurofibromatosis I gene product, neurofibromin, in blood vessel endothelial cells and smooth muscle. Neurobiology of Disease. 2: 13-21. PMID 8980005 DOI: 10.1006/Nbdi.1995.0002  0.313
1995 Gutmann DH. Tumor suppressor genes as negative growth regulators in development and differentiation International Journal of Developmental Biology. 39: 895-907. PMID 8901192 DOI: 10.1387/Ijdb.8901192  0.38
1995 Gutmann DH, Silos-Santiago I, Geist RT, Daras M, Rutkowski JL. Lack of NF1 expression in a sporadic schwannoma from a patient without neurofibromatosis. Journal of Neuro-Oncology. 25: 103-11. PMID 8543966 DOI: 10.1007/Bf01057754  0.465
1995 Gutmann DH, Wright DE, Geist RT, Snider WD. Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Human Molecular Genetics. 4: 471-8. PMID 7795605 DOI: 10.1093/Hmg/4.3.471  0.332
1995 Gutmann DH, Geist RT, Rose K, Wright DE. Expression of two new protein isoforms of the neurofibromatosis type 1 gene product, neurofibromin, in muscle tissues. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 202: 302-11. PMID 7780179 DOI: 10.1002/Aja.1002020309  0.309
1995 Hewett SJ, Choi DW, Gutmann DH. Expression of the neurofibromatosis 1 (NF1) gene in reactive astrocytes in vitro. Neuroreport. 6: 1565-8. PMID 7579150 DOI: 10.1097/00001756-199507310-00025  0.4
1995 Gutmann DH, Cole JL, Collins FS. Expression of the neurofibromatosis type 1 (NF1) gene during mouse embryonic development. Progress in Brain Research. 105: 327-35. PMID 7568895 DOI: 10.1016/S0079-6123(08)63311-7  0.412
1995 Gutmann DH, Geist RT, Rose K, Wallin G, Moley JF. Loss of neurofibromatosis type I (NF1) gene expression in pheochromocytomas from patients without NF1. Genes, Chromosomes & Cancer. 13: 104-9. PMID 7542904 DOI: 10.1002/Gcc.2870130206  0.462
1994 Gutmann DH. New insights into the neurofibromatoses Current Opinion in Neurology. 7: 166-171. PMID 8019663 DOI: 10.1097/00019052-199404000-00014  0.447
1994 Gutmann DH, Cole JL, Stone WJ, Ponder BA, Collins FS. Loss of neurofibromin in adrenal gland tumors from patients with neurofibromatosis type I. Genes, Chromosomes & Cancer. 10: 55-8. PMID 7519874 DOI: 10.1002/Gcc.2870100109  0.437
1993 Andersen LB, Fountain JW, Gutmann DH, Tarlé SA, Glover TW, Dracopoli NC, Housman DE, Collins FS. Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines. Nature Genetics. 3: 118-21. PMID 8499944 DOI: 10.1038/Ng0293-118  0.422
1993 Gutmann DH, Collins FS. The neurofibromatosis type 1 gene and its protein product, neurofibromin Neuron. 10: 335-343. PMID 8461130 DOI: 10.1016/0896-6273(93)90324-K  0.35
1993 Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Molecular and Cellular Biology. 13: 487-95. PMID 8417346 DOI: 10.1128/Mcb.13.1.487  0.344
1993 Gregory PE, Gutmann DH, Mitchell A, Park S, Boguski M, Jacks T, Wood DL, Jove R, Collins FS. Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somatic Cell and Molecular Genetics. 19: 265-74. PMID 8332934 DOI: 10.1007/Bf01233074  0.317
1993 Gutmann DH, Collins FS. Neurofibromatosis Type 1: Beyond Positional Cloning Archives of Neurology. 50: 1185-1193. PMID 8215978 DOI: 10.1001/Archneur.1993.00540110065007  0.336
1993 Gutmann DH, Tennekoon GI, Cole JL, Collins FS, Rutkowski JL. Modulation of the neurofibromatosis type 1 gene product, neurofibromin, during Schwann cell differentiation. Journal of Neuroscience Research. 36: 216-23. PMID 7505343 DOI: 10.1002/Jnr.490360212  0.385
1992 Gutmann DH, Collins FS. Recent progress toward understanding the molecular biology of von Recklinghausen neurofibromatosis Annals of Neurology. 31: 555-561. PMID 1596091 DOI: 10.1002/Ana.410310515  0.359
1992 Basu TN, Gutmann DH, Fletcher JA, Glover TW, Collins FS, Downward J. Aberrant regulation of ras proteins in malignant tumour cells from type 1 neurofibromatosis patients. Nature. 356: 713-5. PMID 1570015 DOI: 10.1038/356713A0  0.388
1991 Marchuk DA, Saulino AM, Tavakkol R, Swaroop M, Wallace MR, Andersen LB, Mitchell AL, Gutmann DH, Boguski M, Collins FS. cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics. 11: 931-40. PMID 1783401 DOI: 10.1016/0888-7543(91)90017-9  0.322
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