Kimberly Huber - Publications

Affiliations: 
University of Texas Southwestern Medical Center, Dallas, TX, United States 
Area:
ltd, hippocampus

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Schaefer TL, Ashworth AA, Tiwari D, Tomasek MP, Parkins EV, White AR, Snider A, Davenport MH, Grainger LM, Becker RA, Robinson CK, Mukherjee R, Williams MT, Gibson JR, Huber KM, et al. GABA Alpha 2,3 Modulation Improves Select Phenotypes in a Mouse Model of Fragile X Syndrome. Frontiers in Psychiatry. 12: 678090. PMID 34093287 DOI: 10.3389/fpsyt.2021.678090  1
2020 McCamphill PK, Stoppel LJ, Senter RK, Lewis MC, Heynen AJ, Stoppel DC, Sridhar V, Collins KA, Shi X, Pan JQ, Madison J, Cottrell JR, Huber KM, Scolnick EM, Holson EB, et al. Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome. Science Translational Medicine. 12. PMID 32434848 DOI: 10.1126/Scitranslmed.Aam8572  1
2019 Gonzalez D, Tomasek M, Hays S, Sridhar V, Ammanuel S, Chang CW, Pawlowski K, Huber KM, Gibson JR. Audiogenic seizures in the knockout mouse are induced by deletion in subcortical, vGlut2-expressing excitatory neurons and require deletion in the Inferior Colliculus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31666356 DOI: 10.1523/Jneurosci.0886-19.2019  1
2019 Goswami S, Cavalier S, Sridhar V, Huber KM, Gibson JR. Local cortical circuit correlates of altered EEG in the mouse model of Fragile X syndrome. Neurobiology of Disease. PMID 30639292 DOI: 10.1016/j.nbd.2019.01.002  1
2017 Barylko B, Wilkerson JR, Cavalier SH, Binns DD, James NG, Jameson DM, Huber KM, Albanesi JP. Palmitoylation and Membrane Binding of Arc/Arg3.1: A Potential Role in Synaptic Depression. Biochemistry. PMID 29264923 DOI: 10.1021/Acs.Biochem.7B00959  0.68
2017 Wilkerson JR, Albanesi JP, Huber KM. Roles for Arc in metabotropic glutamate receptor-dependent LTD and synapse elimination: Implications in health and disease. Seminars in Cell & Developmental Biology. PMID 28969983 DOI: 10.1016/j.semcdb.2017.09.035  0.68
2017 Chang CW, Wilkerson J, Hale C, Gibson JR, Huber KM. Distinct stages of synapse elimination are induced by burst firing of CA1 neurons and differentially require MEF2A/D. Elife. 6. PMID 28901289 DOI: 10.7554/eLife.26278  1
2017 Tsai NP, Huber KM. Protocadherins and the Social Brain. Biological Psychiatry. 81: 173-174. PMID 28024704 DOI: 10.1016/j.biopsych.2016.10.025  1
2016 Tsai NP, Wilkerson JR, Guo W, Huber KM. FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination. Human Molecular Genetics. PMID 28025327 DOI: 10.1093/hmg/ddw386  1
2016 Westmark CJ, Chuang SC, Hays SA, Filon MJ, Ray BC, Westmark PR, Gibson JR, Huber KM, Wong RK. APP Causes Hyperexcitability in Fragile X Mice. Frontiers in Molecular Neuroscience. 9: 147. PMID 28018172 DOI: 10.3389/fnmol.2016.00147  1
2016 Rajkovich KE, Loerwald KW, Hale CF, Hess CT, Gibson JR, Huber KM. Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c. Neuron. PMID 27989458 DOI: 10.1016/j.neuron.2016.11.022  1
2016 Harrington AJ, Raissi A, Rajkovich K, Berto S, Kumar J, Molinaro G, Raduazzo J, Guo Y, Loerwald K, Konopka G, Huber KM, Cowan CW. MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife. 5. PMID 27779093 DOI: 10.7554/Elife.20059  0.44
2016 Ade KK, Wan Y, Hamann HC, O'Hare JK, Guo W, Quian A, Kumar S, Bhagat S, Rodriguiz RM, Wetsel WC, Conn PJ, Dzirasa K, Huber KM, Calakos N. Increased Metabotropic Glutamate Receptor 5 Signaling Underlies Obsessive-Compulsive Disorder-like Behavioral and Striatal Circuit Abnormalities in Mice. Biological Psychiatry. PMID 27436084 DOI: 10.1016/J.Biopsych.2016.04.023  0.48
2016 Guo W, Molinaro G, Collins KA, Hays SA, Paylor R, Worley PF, Szumlinski KK, Huber KM. Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 2131-47. PMID 26888925 DOI: 10.1523/JNEUROSCI.2921-15.2016  1
2015 Guo W, Ceolin L, Collins KA, Perroy J, Huber KM. Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model. Cell Reports. PMID 26670047 DOI: 10.1016/j.celrep.2015.11.013  0.48
2015 Huber KM, Klann E, Costa-Mattioli M, Zukin RS. Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13836-42. PMID 26468183 DOI: 10.1523/Jneurosci.2656-15.2015  1
2015 Zhang Z, Cao M, Chang CW, Wang C, Shi X, Zhan X, Birnbaum SG, Bezprozvanny I, Huber K, Wu JI. Autism-Associated Chromatin Regulator Brg1/SmarcA4 is Required for Synapse Development and MEF2-mediated Synapse Remodeling. Molecular and Cellular Biology. PMID 26459759 DOI: 10.1128/Mcb.00534-15  1
2015 Gross C, Chang CW, Kelly SM, Bhattacharya A, McBride SM, Danielson SW, Jiang MQ, Chan CB, Ye K, Gibson JR, Klann E, Jongens TA, Moberg KH, Huber KM, Bassell GJ. Increased expression of the PI3K enhancer PIKE mediates deficits in synaptic plasticity and behavior in fragile X syndrome. Cell Reports. 11: 727-36. PMID 25921541 DOI: 10.1016/J.Celrep.2015.03.060  1
2015 Gross C, Raj N, Molinaro G, Allen AG, Whyte AJ, Gibson JR, Huber KM, Gourley SL, Bassell GJ. Selective role of the catalytic PI3K subunit p110β in impaired higher order cognition in fragile X syndrome. Cell Reports. 11: 681-8. PMID 25921527 DOI: 10.1016/J.Celrep.2015.03.065  1
2015 Byers CE, Barylko B, Ross JA, Southworth DR, James NG, Taylor CA, Wang L, Collins KA, Estrada A, Waung M, Tassin TC, Huber KM, Jameson DM, Albanesi JP. Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochimica Et Biophysica Acta. 1850: 1310-8. PMID 25783003 DOI: 10.1016/J.Bbagen.2015.03.002  1
2015 Fan J, Zeng H, Olson DP, Huber KM, Gibson JR, Takahashi JS. Vasoactive intestinal polypeptide (VIP)-expressing neurons in the suprachiasmatic nucleus provide sparse GABAergic outputs to local neurons with circadian regulation occurring distal to the opening of postsynaptic GABAA ionotropic receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1905-20. PMID 25653351 DOI: 10.1523/Jneurosci.2661-14.2015  1
2015 Loerwald KW, Patel AB, Huber KM, Gibson JR. Postsynaptic mGluR5 promotes evoked AMPAR-mediated synaptic transmission onto neocortical layer 2/3 pyramidal neurons during development. Journal of Neurophysiology. 113: 786-95. PMID 25392167 DOI: 10.1152/jn.00465.2014  1
2014 Wilkerson JR, Tsai NP, Maksimova MA, Wu H, Cabalo NP, Loerwald KW, Dictenberg JB, Gibson JR, Huber KM. A role for dendritic mGluR5-mediated local translation of Arc/Arg3.1 in MEF2-dependent synapse elimination. Cell Reports. 7: 1589-600. PMID 24857654 DOI: 10.1016/j.celrep.2014.04.035  1
2014 Smith LN, Jedynak JP, Fontenot MR, Hale CF, Dietz KC, Taniguchi M, Thomas FS, Zirlin BC, Birnbaum SG, Huber KM, Thomas MJ, Cowan CW. Fragile X mental retardation protein regulates synaptic and behavioral plasticity to repeated cocaine administration. Neuron. 82: 645-58. PMID 24811383 DOI: 10.1016/J.Neuron.2014.03.028  1
2014 Patel AB, Loerwald KW, Huber KM, Gibson JR. Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3413-8. PMID 24573297 DOI: 10.1523/JNEUROSCI.2921-13.2014  1
2014 D'Antoni S, Spatuzza M, Bonaccorso CM, Musumeci SA, Ciranna L, Nicoletti F, Huber KM, Catania MV. Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neuroscience and Biobehavioral Reviews. 46: 228-41. PMID 24548786 DOI: 10.1016/J.Neubiorev.2014.02.003  1
2013 Jakkamsetti V, Tsai NP, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR, Huber KM. Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression. Neuron. 80: 72-9. PMID 24094104 DOI: 10.1016/J.Neuron.2013.07.020  1
2013 Liu ML, Zang T, Zou Y, Chang JC, Gibson JR, Huber KM, Zhang CL. Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nature Communications. 4: 2183. PMID 23873306 DOI: 10.1038/ncomms3183  1
2013 Zang T, Maksimova MA, Cowan CW, Bassel-Duby R, Olson EN, Huber KM. Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Molecular and Cellular Neurosciences. 56: 39-49. PMID 23511190 DOI: 10.1016/J.Mcn.2013.03.002  1
2013 Patel AB, Hays SA, Bureau I, Huber KM, Gibson JR. A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2593-604. PMID 23392687 DOI: 10.1523/JNEUROSCI.2447-12.2013  1
2012 Tsai NP, Wilkerson JR, Guo W, Maksimova MA, DeMartino GN, Cowan CW, Huber KM. Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell. 151: 1581-94. PMID 23260144 DOI: 10.1016/J.Cell.2012.11.040  1
2012 Niere F, Wilkerson JR, Huber KM. Evidence for a fragile X mental retardation protein-mediated translational switch in metabotropic glutamate receptor-triggered Arc translation and long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5924-36. PMID 22539853 DOI: 10.1523/Jneurosci.4650-11.2012  1
2012 Ronesi JA, Collins KA, Hays SA, Tsai NP, Guo W, Birnbaum SG, Hu JH, Worley PF, Gibson JR, Huber KM. Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome. Nature Neuroscience. 15: 431-40, S1. PMID 22267161 DOI: 10.1038/nn.3033  1
2011 Hays SA, Huber KM, Gibson JR. Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14223-34. PMID 21976507 DOI: 10.1523/JNEUROSCI.3157-11.2011  1
2010 Pfeiffer BE, Zang T, Wilkerson JR, Taniguchi M, Maksimova MA, Smith LN, Cowan CW, Huber KM. Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron. 66: 191-7. PMID 20434996 DOI: 10.1016/J.Neuron.2010.03.017  1
2010 Lüscher C, Huber KM. Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. Neuron. 65: 445-59. PMID 20188650 DOI: 10.1016/j.neuron.2010.01.016  1
2009 Zang JB, Nosyreva ED, Spencer CM, Volk LJ, Musunuru K, Zhong R, Stone EF, Yuva-Paylor LA, Huber KM, Paylor R, Darnell JC, Darnell RB. A mouse model of the human Fragile X syndrome I304N mutation. Plos Genetics. 5: e1000758. PMID 20011099 DOI: 10.1371/journal.pgen.1000758  1
2009 Gibson JR, Huber KM, Südhof TC. Neuroligin-2 deletion selectively decreases inhibitory synaptic transmission originating from fast-spiking but not from somatostatin-positive interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 13883-97. PMID 19889999 DOI: 10.1523/JNEUROSCI.2457-09.2009  1
2009 Waung MW, Huber KM. Protein translation in synaptic plasticity: mGluR-LTD, Fragile X. Current Opinion in Neurobiology. 19: 319-26. PMID 19411173 DOI: 10.1016/J.Conb.2009.03.011  1
2009 Pfeiffer BE, Huber KM. The state of synapses in fragile X syndrome. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 15: 549-67. PMID 19325170 DOI: 10.1177/1073858409333075  1
2008 Gibson JR, Bartley AF, Hays SA, Huber KM. Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. Journal of Neurophysiology. 100: 2615-26. PMID 18784272 DOI: 10.1152/Jn.90752.2008  1
2008 Bartley AF, Huang ZJ, Huber KM, Gibson JR. Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits. Journal of Neurophysiology. 100: 1983-94. PMID 18701752 DOI: 10.1152/Jn.90635.2008  1
2008 Waung MW, Pfeiffer BE, Nosyreva ED, Ronesi JA, Huber KM. Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron. 59: 84-97. PMID 18614031 DOI: 10.1016/J.Neuron.2008.05.014  1
2008 Ronesi JA, Huber KM. Metabotropic glutamate receptors and fragile x mental retardation protein: partners in translational regulation at the synapse. Science Signaling. 1: pe6. PMID 18272470 DOI: 10.1126/stke.15pe6  1
2008 Ronesi JA, Huber KM. Homer interactions are necessary for metabotropic glutamate receptor-induced long-term depression and translational activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 543-7. PMID 18184796 DOI: 10.1523/JNEUROSCI.5019-07.2008  1
2007 Volk LJ, Pfeiffer BE, Gibson JR, Huber KM. Multiple Gq-coupled receptors converge on a common protein synthesis-dependent long-term depression that is affected in fragile X syndrome mental retardation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 11624-34. PMID 17959805 DOI: 10.1523/Jneurosci.2266-07.2007  1
2007 Huber K. Fragile X syndrome: molecular mechanisms of cognitive dysfunction. The American Journal of Psychiatry. 164: 556. PMID 17403966 DOI: 10.1176/ajp.2007.164.4.556  1
2007 Pfeiffer BE, Huber KM. Fragile X mental retardation protein induces synapse loss through acute postsynaptic translational regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3120-30. PMID 17376973 DOI: 10.1523/Jneurosci.0054-07.2007  1
2006 Pfeiffer BE, Huber KM. Current advances in local protein synthesis and synaptic plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7147-50. PMID 16822970 DOI: 10.1523/Jneurosci.1797-06.2006  1
2006 Gibson JR, Bartley AF, Huber KM. Role for the subthreshold currents ILeak and IH in the homeostatic control of excitability in neocortical somatostatin-positive inhibitory neurons. Journal of Neurophysiology. 96: 420-32. PMID 16687614 DOI: 10.1152/Jn.01203.2005  1
2006 Kotti TJ, Ramirez DM, Pfeiffer BE, Huber KM, Russell DW. Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 3869-74. PMID 16505352 DOI: 10.1073/Pnas.0600316103  1
2006 Huber KM. The fragile X-cerebellum connection. Trends in Neurosciences. 29: 183-5. PMID 16500716 DOI: 10.1016/j.tins.2006.02.001  1
2006 Nosyreva ED, Huber KM. Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome. Journal of Neurophysiology. 95: 3291-5. PMID 16452252 DOI: 10.1152/jn.01316.2005  1
2006 Volk LJ, Daly CA, Huber KM. Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression. Journal of Neurophysiology. 95: 2427-38. PMID 16421200 DOI: 10.1152/jn.00383.2005  1
2005 Nosyreva ED, Huber KM. Developmental switch in synaptic mechanisms of hippocampal metabotropic glutamate receptor-dependent long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2992-3001. PMID 15772359 DOI: 10.1523/JNEUROSCI.3652-04.2005  1
2004 Bear MF, Huber KM, Warren ST. The mGluR theory of fragile X mental retardation. Trends in Neurosciences. 27: 370-7. PMID 15219735 DOI: 10.1016/J.Tins.2004.04.009  1
2004 Gallagher SM, Daly CA, Bear MF, Huber KM. Extracellular signal-regulated protein kinase activation is required for metabotropic glutamate receptor-dependent long-term depression in hippocampal area CA1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4859-64. PMID 15152046 DOI: 10.1523/JNEUROSCI.5407-03.2004  1
2002 Huber KM, Gallagher SM, Warren ST, Bear MF. Altered synaptic plasticity in a mouse model of fragile X mental retardation. Proceedings of the National Academy of Sciences of the United States of America. 99: 7746-50. PMID 12032354 DOI: 10.1073/Pnas.122205699  1
2001 Snyder EM, Philpot BD, Huber KM, Dong X, Fallon JR, Bear MF. Internalization of ionotropic glutamate receptors in response to mGluR activation. Nature Neuroscience. 4: 1079-85. PMID 11687813 DOI: 10.1038/nn746  1
2001 Huber KM, Roder JC, Bear MF. Chemical induction of mGluR5- and protein synthesis--dependent long-term depression in hippocampal area CA1. Journal of Neurophysiology. 86: 321-5. PMID 11431513 DOI: 10.1152/Jn.2001.86.1.321  1
2001 Hannan AJ, Blakemore C, Katsnelson A, Vitalis T, Huber KM, Bear M, Roder J, Kim D, Shin HS, Kind PC. PLC-beta1, activated via mGluRs, mediates activity-dependent differentiation in cerebral cortex. Nature Neuroscience. 4: 282-8. PMID 11224545 DOI: 10.1038/85132  1
2000 Huber KM, Kayser MS, Bear MF. Role for rapid dendritic protein synthesis in hippocampal mGluR-dependent long-term depression. Science (New York, N.Y.). 288: 1254-7. PMID 10818003 DOI: 10.1126/science.288.5469.1254  1
1999 Sawtell NB, Huber KM, Roder JC, Bear MF. Induction of NMDA receptor-dependent long-term depression in visual cortex does not require metabotropic glutamate receptors. Journal of Neurophysiology. 82: 3594-7. PMID 10601487 DOI: 10.1152/Jn.1999.82.6.3594  1
1998 Huber KM, Sawtell NB, Bear MF. Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex. Neuropharmacology. 37: 571-9. PMID 9704998 DOI: 10.1016/S0028-3908(98)00050-1  1
1998 Huber KM, Sawtell NB, Bear MF. Effects of the metabotropic glutamate receptor antagonist MCPG on phosphoinositide turnover and synaptic plasticity in visual cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1-9. PMID 9412480 DOI: 10.1523/Jneurosci.18-01-00001.1998  1
1995 Huber KM, Mauk MD, Thompson C, Kelly PT. A critical period of protein kinase activity after tetanic stimulation is required for the induction of long-term potentiation. Learning & Memory (Cold Spring Harbor, N.Y.). 2: 81-100. PMID 10467568 DOI: 10.1101/Lm.2.2.81  1
1995 Huber KM, Mauk MD, Kelly PT. Distinct LTP induction mechanisms: contribution of NMDA receptors and voltage-dependent calcium channels. Journal of Neurophysiology. 73: 270-9. PMID 7714571 DOI: 10.1152/Jn.1995.73.1.270  1
1995 Huber KM, Mauk MD, Kelly PT. LTP induced by activation of voltage-dependent Ca2+ channels requires protein kinase activity. Neuroreport. 6: 1281-4. PMID 7669987 DOI: 10.1097/00001756-199506090-00013  1
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