Year |
Citation |
Score |
2023 |
Gonçalves D, Peffer S, Morano KA. Cytoplasmic redox imbalance in the thioredoxin system activates Hsf1 and results in hyperaccumulation of the sequestrase Hsp42 with misfolded proteins. Biorxiv : the Preprint Server For Biology. PMID 37425817 DOI: 10.1101/2023.06.26.546610 |
0.457 |
|
2022 |
Santiago A, Morano KA. Oxidation of two cysteines within yeast Hsp70 impairs proteostasis while directly triggering an Hsf1-dependent cytoprotective response. The Journal of Biological Chemistry. 102424. PMID 36030825 DOI: 10.1016/j.jbc.2022.102424 |
0.444 |
|
2022 |
Freije BJ, Freije WM, Do TU, Adkins GE, Bruch A, Hurtig JE, Morano KA, Schaffrath R, West JD. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Chemical Research in Toxicology. PMID 35084835 DOI: 10.1021/acs.chemrestox.1c00376 |
0.324 |
|
2021 |
Hohrman K, Gonçalves D, Morano KA, Johnson JL. Disrupting progression of the yeast Hsp90 folding pathway at different transition points results in client-specific maturation defects. Genetics. 217. PMID 33789348 DOI: 10.1093/genetics/iyab009 |
0.524 |
|
2020 |
Gonçalves D, Santiago A, Morano KA. When pH comes to the rescue. Elife. 9. PMID 32915136 DOI: 10.7554/Elife.62022 |
0.343 |
|
2020 |
Santiago AM, Gonçalves DL, Morano KA. Mechanisms of sensing and response to proteotoxic stress. Experimental Cell Research. 395: 112240. PMID 32827554 DOI: 10.1016/J.Yexcr.2020.112240 |
0.38 |
|
2020 |
Verstrepen KJ, Morano K. Decision letter: Transient intracellular acidification regulates the core transcriptional heat shock response Elife. DOI: 10.7554/Elife.54880.Sa1 |
0.4 |
|
2019 |
Peffer S, Gonçalves D, Morano KA. Regulation of the Hsf1-dependent transcriptome via conserved bipartite contacts with Hsp70 promotes survival in yeast. The Journal of Biological Chemistry. PMID 31239354 DOI: 10.1074/Jbc.Ra119.008822 |
0.598 |
|
2019 |
Loberg MA, Hurtig JE, Graff AH, Allan KM, Buchan JA, Spencer MK, Kelly JE, Clodfelter JE, Morano KA, Lowther WT, West JD. Aromatic Residues at the Dimer-Dimer Interface in the Peroxiredoxin Tsa1 Facilitate Decamer Formation and Biological Function. Chemical Research in Toxicology. PMID 30701970 DOI: 10.1021/Acs.Chemrestox.8B00346 |
0.381 |
|
2019 |
Ford AE, Denicourt C, Morano KA. Thiol stress-dependent aggregation of the glycolytic enzyme triose phosphate isomerase in yeast and human cells. Molecular Biology of the Cell. mbcE18100616. PMID 30601716 DOI: 10.1091/Mbc.E18-10-0616 |
0.482 |
|
2019 |
Morano K, Pincus D. Decision letter: Cytoplasmic protein misfolding titrates Hsp70 to activate nuclear Hsf1 Elife. DOI: 10.7554/Elife.47791.028 |
0.445 |
|
2018 |
Yakubu UM, Morano KA. Roles of the nucleotide exchange factor and chaperone Hsp110 in cellular proteostasis and diseases of protein misfolding. Biological Chemistry. PMID 29908125 DOI: 10.1515/Hsz-2018-0209 |
0.508 |
|
2017 |
Garcia VM, Nillegoda NB, Bukau B, Morano KA. Substrate binding by the yeast Hsp110 nucleotide exchange factor and molecular chaperone, Sse1, is not obligate for its biological activities. Molecular Biology of the Cell. PMID 28539411 DOI: 10.1091/Mbc.E17-01-0070 |
0.574 |
|
2016 |
Allan KM, Loberg MA, Chepngeno J, Hurtig JE, Tripathi S, Kang MG, Allotey JK, Widdershins AH, Pilat JM, Sizek HJ, Murphy WJ, Naticchia MR, David JB, Morano KA, West JD. Trapping Redox Partnerships in Oxidant-Sensitive Proteins with a Small, Thiol-Reactive Cross-Linker. Free Radical Biology & Medicine. PMID 27816612 DOI: 10.1016/J.Freeradbiomed.2016.10.506 |
0.345 |
|
2016 |
Garcia VM, Rowlett VW, Margolin W, Morano KA. Semi-automated microplate monitoring of protein polymerization and aggregation. Analytical Biochemistry. PMID 27251433 DOI: 10.1016/J.Ab.2016.05.016 |
0.325 |
|
2015 |
Morano KA. Groupthink: chromosomal clustering during transcriptional memory. Microbial Cell (Graz, Austria). 2: 454-457. PMID 28357270 DOI: 10.15698/Mic2015.12.244 |
0.387 |
|
2014 |
Morano KA. Anhydrobiosis: drying out with sugar. Current Biology : Cb. 24: R1121-3. PMID 25465329 DOI: 10.1016/J.Cub.2014.10.022 |
0.322 |
|
2014 |
Morano KA, Sistonen L, Mezger V. Heat shock in the springtime. Cell Stress & Chaperones. 19: 753-61. PMID 25199949 DOI: 10.1007/S12192-014-0539-Y |
0.432 |
|
2014 |
Abrams JL, Verghese J, Gibney PA, Morano KA. Hierarchical functional specificity of cytosolic heat shock protein 70 (Hsp70) nucleotide exchange factors in yeast. The Journal of Biological Chemistry. 289: 13155-67. PMID 24671421 DOI: 10.1074/Jbc.M113.530014 |
0.811 |
|
2013 |
Abrams JL, Morano KA. Coupled assays for monitoring protein refolding in Saccharomyces cerevisiae. Journal of Visualized Experiments : Jove. e50432. PMID 23892247 DOI: 10.3791/50432 |
0.461 |
|
2013 |
Naticchia MR, Brown HA, Garcia FJ, Lamade AM, Justice SL, Herrin RP, Morano KA, West JD. Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells. Chemical Research in Toxicology. 26: 490-7. PMID 23414292 DOI: 10.1021/Tx4000123 |
0.382 |
|
2012 |
Wang Y, Gibney PA, West JD, Morano KA. The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds. Molecular Biology of the Cell. 23: 3290-8. PMID 22809627 DOI: 10.1091/Mbc.E12-06-0447 |
0.773 |
|
2012 |
West JD, Wang Y, Morano KA. Small molecule activators of the heat shock response: chemical properties, molecular targets, and therapeutic promise. Chemical Research in Toxicology. 25: 2036-53. PMID 22799889 DOI: 10.1021/Tx300264X |
0.496 |
|
2012 |
Verghese J, Abrams J, Wang Y, Morano KA. Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system. Microbiology and Molecular Biology Reviews : Mmbr. 76: 115-58. PMID 22688810 DOI: 10.1128/Mmbr.05018-11 |
0.542 |
|
2012 |
Verghese J, Morano KA. A lysine-rich region within fungal BAG domain-containing proteins mediates a novel association with ribosomes. Eukaryotic Cell. 11: 1003-11. PMID 22635919 DOI: 10.1128/Ec.00146-12 |
0.541 |
|
2012 |
Morano KA, Grant CM, Moye-Rowley WS. The response to heat shock and oxidative stress in Saccharomyces cerevisiae. Genetics. 190: 1157-95. PMID 22209905 DOI: 10.1534/Genetics.111.128033 |
0.404 |
|
2011 |
West JD, Stamm CE, Brown HA, Justice SL, Morano KA. Enhanced toxicity of the protein cross-linkers divinyl sulfone and diethyl acetylenedicarboxylate in comparison to related monofunctional electrophiles. Chemical Research in Toxicology. 24: 1457-9. PMID 21812477 DOI: 10.1021/Tx200302W |
0.358 |
|
2010 |
Mandal AK, Gibney PA, Nillegoda NB, Theodoraki MA, Caplan AJ, Morano KA. Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system. Molecular Biology of the Cell. 21: 1439-48. PMID 20237159 DOI: 10.1091/Mbc.E09-09-0779 |
0.798 |
|
2010 |
Tapia H, Morano KA. Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast. Molecular Biology of the Cell. 21: 63-72. PMID 19889838 DOI: 10.1091/Mbc.E09-05-0376 |
0.59 |
|
2008 |
Schuermann JP, Jiang J, Cuellar J, Llorca O, Wang L, Gimenez LE, Jin S, Taylor AB, Demeler B, Morano KA, Hart PJ, Valpuesta JM, Lafer EM, Sousa R. Structure of the Hsp110:Hsc70 nucleotide exchange machine. Molecular Cell. 31: 232-43. PMID 18550409 DOI: 10.1016/J.Molcel.2008.05.006 |
0.527 |
|
2008 |
Shaner L, Gibney PA, Morano KA. The Hsp110 protein chaperone Sse1 is required for yeast cell wall integrity and morphogenesis. Current Genetics. 54: 1-11. PMID 18478233 DOI: 10.1007/S00294-008-0193-Y |
0.798 |
|
2008 |
Gibney PA, Fries T, Bailer SM, Morano KA. Rtr1 is the Saccharomyces cerevisiae homolog of a novel family of RNA polymerase II-binding proteins. Eukaryotic Cell. 7: 938-48. PMID 18408053 DOI: 10.1128/Ec.00042-08 |
0.756 |
|
2008 |
Trott A, West JD, Klai? L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Molecular Biology of the Cell. 19: 1104-12. PMID 18199679 DOI: 10.1091/Mbc.E07-10-1004 |
0.787 |
|
2007 |
Fan Q, Park KW, Du Z, Morano KA, Li L. The role of Sse1 in the de novo formation and variant determination of the [PSI+] prion. Genetics. 177: 1583-93. PMID 18039878 DOI: 10.1534/Genetics.107.077982 |
0.541 |
|
2007 |
Morano KA. New tricks for an old dog: the evolving world of Hsp70. Annals of the New York Academy of Sciences. 1113: 1-14. PMID 17513460 DOI: 10.1196/Annals.1391.018 |
0.558 |
|
2007 |
Shaner L, Morano KA. All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity. Cell Stress & Chaperones. 12: 1-8. PMID 17441502 DOI: 10.1379/Csc-245R.1 |
0.814 |
|
2006 |
Shaner L, Sousa R, Morano KA. Characterization of Hsp70 binding and nucleotide exchange by the yeast Hsp110 chaperone Sse1. Biochemistry. 45: 15075-84. PMID 17154545 DOI: 10.1021/Bi061279K |
0.821 |
|
2005 |
Shaner L, Wegele H, Buchner J, Morano KA. The yeast Hsp110 Sse1 functionally interacts with the Hsp70 chaperones Ssa and Ssb. The Journal of Biological Chemistry. 280: 41262-9. PMID 16221677 DOI: 10.1074/Jbc.M503614200 |
0.821 |
|
2005 |
Trott A, Shaner L, Morano KA. The molecular chaperone Sse1 and the growth control protein kinase Sch9 collaborate to regulate protein kinase A activity in Saccharomyces cerevisiae. Genetics. 170: 1009-21. PMID 15879503 DOI: 10.1534/Genetics.105.043109 |
0.734 |
|
2005 |
Pelletier B, Trott A, Morano KA, Labbé S. Functional characterization of the iron-regulatory transcription factor Fep1 from Schizosaccharomyces pombe. The Journal of Biological Chemistry. 280: 25146-61. PMID 15866870 DOI: 10.1074/Jbc.M502947200 |
0.758 |
|
2004 |
Trott A, Morano KA. SYM1 is the stress-induced Saccharomyces cerevisiae ortholog of the mammalian kidney disease gene Mpv17 and is required for ethanol metabolism and tolerance during heat shock. Eukaryotic Cell. 3: 620-31. PMID 15189984 DOI: 10.1128/Ec.3.3.620-631.2004 |
0.786 |
|
2004 |
Shaner L, Trott A, Goeckeler JL, Brodsky JL, Morano KA. The function of the yeast molecular chaperone Sse1 is mechanistically distinct from the closely related hsp70 family. The Journal of Biological Chemistry. 279: 21992-2001. PMID 15028727 DOI: 10.1074/Jbc.M313739200 |
0.755 |
|
2003 |
Bali M, Zhang B, Morano KA, Michels CA. The Hsp90 molecular chaperone complex regulates maltose induction and stability of the Saccharomyces MAL gene transcription activator Mal63p. The Journal of Biological Chemistry. 278: 47441-8. PMID 14500708 DOI: 10.1074/Jbc.M309536200 |
0.565 |
|
2002 |
Bellemare DR, Shaner L, Morano KA, Beaudoin J, Langlois R, Labbe S. Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. The Journal of Biological Chemistry. 277: 46676-86. PMID 12244050 DOI: 10.1074/Jbc.M206444200 |
0.755 |
|
1999 |
Morano KA, Thiele DJ. The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo Embo Journal. 18: 5953-5962. PMID 10545107 DOI: 10.1093/Emboj/18.21.5953 |
0.582 |
|
1999 |
Liu XD, Morano KA, Thiele DJ. The yeast Hsp110 family member, Sse1, is an Hsp90 cochaperone Journal of Biological Chemistry. 274: 26654-26660. PMID 10480867 DOI: 10.1074/Jbc.274.38.26654 |
0.61 |
|
1999 |
Morano KA, Thiele DJ. Heat shock factor function and regulation in response to cellular stress, growth, and differentiation signals Gene Expression. 7: 271-282. PMID 10440228 |
0.404 |
|
1999 |
Morano KA, Santoro N, Koch KA, Thiele DJ. A trans-activation domain in yeast heat shock transcription factor is essential for cell cycle progression during stress. Molecular and Cellular Biology. 19: 402-11. PMID 9858564 DOI: 10.1128/Mcb.19.1.402 |
0.58 |
|
1998 |
Morano KA, Liu PCC, Thiele DJ. Protein chaperones and the heat shock response in Saccharomyces cerevisiae Current Opinion in Microbiology. 1: 197-203. PMID 10066474 DOI: 10.1016/S1369-5274(98)80011-8 |
0.515 |
|
1997 |
Matoba S, Morano KA, Klionsky DJ, Kim K, Ogrydziak DM. Dipeptidyl aminopeptidase processing and biosynthesis of alkaline extracellular protease from Yarrowia lipolytica Microbiology. 143: 3263-3272. PMID 9353927 DOI: 10.1099/00221287-143-10-3263 |
0.331 |
|
1996 |
Scott SV, Hefner-Gravink A, Morano KA, Noda T, Ohsumi Y, Klionsky DJ. Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole Proceedings of the National Academy of Sciences of the United States of America. 93: 12304-12308. PMID 8901576 DOI: 10.1073/Pnas.93.22.12304 |
0.377 |
|
1995 |
Harding TM, Morano KA, Scott SV, Klionsky DJ. Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway Journal of Cell Biology. 131: 591-602. PMID 7593182 DOI: 10.1083/Jcb.131.3.591 |
0.4 |
|
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