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Scott D. PEgan - Publications

Affiliations: 
Chemistry and Biochemistry University of Denver, Denver, CO, United States 
Area:
General Biophysics, Epidemiology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Shepard JD, Freitas BT, Rodriguez SE, Scholte FEM, Baker K, Hutchison MR, Longo JE, Miller HC, O'Boyle BM, Tandon A, Zhao P, Grimsey NJ, Wells L, Bergeron É, Pegan SD. The Structure and Immune Regulatory Implications of the Ubiquitin-Like Tandem Domain Within an Avian 2'-5' Oligoadenylate Synthetase-Like Protein. Frontiers in Immunology. 12: 794664. PMID 35058932 DOI: 10.3389/fimmu.2021.794664  0.301
2021 Durie IA, Dzimianski JV, Daczkowski CM, McGuire J, Faaberg K, Pegan SD. Structural insights into the interaction of papain-like protease 2 from the alphacoronavirus porcine epidemic diarrhea virus and ubiquitin. Acta Crystallographica. Section D, Structural Biology. 77: 943-953. PMID 34196620 DOI: 10.1107/S205979832100509X  0.346
2020 Dzimianski JV, Mace SL, Williams IL, Freitas BT, Pegan SD. Flipping the substrate preference of Hazara virus ovarian tumour domain protease through structure-based mutagenesis. Acta Crystallographica. Section D, Structural Biology. 76: 1114-1123. PMID 33135682 DOI: 10.1107/S2059798320012875  0.409
2020 Freitas BT, Scholte FEM, Bergeron É, Pegan SD. How ISG15 combats viral infection. Virus Research. 198036. PMID 32492472 DOI: 10.1016/J.Virusres.2020.198036  0.37
2020 Freitas BT, Durie IA, Murray J, Longo JE, Miller HC, Crich D, Hogan RJ, Tripp RA, Pegan SD. Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease. Acs Infectious Diseases. PMID 32428392 DOI: 10.1021/Acsinfecdis.0C00168  0.382
2019 Dzimianski JV, Scholte FEM, Williams IL, Langley C, Freitas BT, Spengler JR, Bergeron É, Pegan SD. Determining the molecular drivers of species-specific interferon-stimulated gene product 15 interactions with nairovirus ovarian tumor domain proteases. Plos One. 14: e0226415. PMID 31869347 DOI: 10.2210/Pdb6Oar/Pdb  0.438
2019 Scholte FEM, Hua BL, Spengler JR, Dzimianski JV, Coleman-McCray JD, Welch SR, McMullan LK, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É. Stable Occupancy of the Crimean-Congo Hemorrhagic Fever Virus-Encoded Deubiquitinase Blocks Viral Infection. Mbio. 10. PMID 31337717 DOI: 10.1128/Mbio.01065-19  0.4
2019 Bester SM, Adipietro KA, Funk VL, Myslinski J, Keul ND, Cheung J, Wilder PT, Wood ZA, Weber DJ, Height JJ, Pegan SD. The structural and biochemical impact of monomerizing human acetylcholinesterase. Protein Science : a Publication of the Protein Society. PMID 30993792 DOI: 10.1002/Pro.3625  0.426
2019 Dzimianski JV, Scholte FEM, Bergeron É, Pegan SD. ISG15: it's Complicated. Journal of Molecular Biology. PMID 30890331 DOI: 10.1016/J.Jmb.2019.03.013  0.39
2019 Langley C, Goodwin O, Dzimianski JV, Daczkowski CM, Pegan SD. Structure of interferon-stimulated gene product 15 (ISG15) from the bat species Myotis davidii and the impact of interdomain ISG15 interactions on viral protein engagement. Acta Crystallographica. Section D, Structural Biology. 75: 21-31. PMID 30644842 DOI: 10.1107/S2059798318015322  0.405
2019 Dzimianski JV, Beldon BS, Daczkowski CM, Goodwin OY, Scholte FEM, Bergeron É, Pegan SD. Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity. Plos Pathogens. 15: e1007515. PMID 30629698 DOI: 10.1371/Journal.Ppat.1007515  0.507
2018 Bester SM, Guelta MA, Cheung J, Winemiller MD, Bae SY, Myslinski J, Pegan SD, Height JJ. Structural insights of stereospecific inhibition of human acetylcholinesterase by VX and subsequent reactivation by HI-6. Chemical Research in Toxicology. PMID 30462502 DOI: 10.1021/acs.chemrestox.8b00294  0.398
2018 Bester SM, Daczkowski CM, Faaberg KS, Pegan SD. Insights into PRRSV viral ovarian tumor domain protease specificity for ubiquitin and interferon-stimulated gene product 15. Acs Infectious Diseases. PMID 29856201 DOI: 10.1021/Acsinfecdis.8B00068  0.4
2017 Kim S, Alsaidan OA, Goodwin O, Li Q, Sulejmani E, Han Z, Bai A, Albers T, Beharry Z, Zheng YGG, Norris JS, Szulc ZM, Bielawska A, Lebedyeva I, Pegan SD, et al. Blocking myristoylation of Src inhibits its kinase activity and suppresses prostate cancer progression. Cancer Research. PMID 29038344 DOI: 10.1158/0008-5472.Can-17-0981  0.302
2017 Daczkowski CM, Goodwin O, Dzimianski JV, Farhat JJ, Pegan SD. Structurally guided removal of deISGylase biochemical activity from papain-Like protease originating from the Middle East Respiratory Syndrome Virus. Journal of Virology. PMID 28931677 DOI: 10.1128/Jvi.01067-17  0.44
2017 Scholte FEM, Zivcec M, Dzimianski JV, Deaton MK, Spengler JR, Welch SR, Nichol ST, Pegan SD, Spiropoulou CF, Bergeron É. Crimean-Congo Hemorrhagic Fever Virus Suppresses Innate Immune Responses via a Ubiquitin and ISG15 Specific Protease. Cell Reports. 20: 2396-2407. PMID 28877473 DOI: 10.1016/J.Celrep.2017.08.040  0.403
2017 Daczkowski CM, Dzimianski JV, Clasman JR, Goodwin O, Mesecar AD, Pegan SD. Structural insights into the interaction of coronavirus papain-like proteases and interferon-stimulated gene product 15 from different species. Journal of Molecular Biology. PMID 28438633 DOI: 10.1016/J.Jmb.2017.04.011  0.477
2016 Deaton MK, Dzimianski JV, Daczkowski CM, Whitney GK, Mank NJ, Parham MM, Bergeron E, Pegan SD. Biochemical and structural insights into nairoviral deISGylases preference for interferon-stimulated-gene-product 15 originating from certain species. Journal of Virology. PMID 27412597 DOI: 10.1128/Jvi.00975-16  0.437
2015 Zivcec M, Metcalfe MG, Albariño CG, Guerrero LW, Pegan SD, Spiropoulou CF, Bergeron É. Assessment of Inhibitors of Pathogenic Crimean-Congo Hemorrhagic Fever Virus Strains Using Virus-Like Particles. Plos Neglected Tropical Diseases. 9: e0004259. PMID 26625182 DOI: 10.1371/Journal.Pntd.0004259  0.322
2015 Daczkowski CM, Pegan SD, Harvey SP. Engineering the Organophosphorus Acid Anhydrolase Enzyme for Increased Catalytic Efficiency and Broadened Stereospecificity on Russian VX. Biochemistry. 54: 6423-33. PMID 26418828 DOI: 10.1021/Acs.Biochem.5B00624  0.417
2015 Eisenmesser EZ, Capodagli GC, Armstrong GS, Holliday MJ, Isern NG, Zhang F, Pegan SD. Inherent dynamics within the Crimean-Congo Hemorrhagic fever virus protease are localized to the same region as substrate interactions. Protein Science : a Publication of the Protein Society. 24: 651-60. PMID 25564798 DOI: 10.1002/Pro.2637  0.75
2014 Capodagli GC, Lee SA, Boehm KJ, Brady KM, Pegan SD. Structural and functional characterization of methicillin-resistant Staphylococcus aureus's class IIb fructose 1,6-bisphosphate aldolase. Biochemistry. 53: 7604-14. PMID 25390935 DOI: 10.1021/Bi501141T  0.735
2014 Zhai X, Go MK, O'Donoghue AC, Amyes TL, Pegan SD, Wang Y, Loria JP, Mesecar AD, Richard JP. Enzyme architecture: the effect of replacement and deletion mutations of loop 6 on catalysis by triosephosphate isomerase. Biochemistry. 53: 3486-501. PMID 24825099 DOI: 10.1021/Bi500458T  0.38
2014 Deaton MK, Spear A, Faaberg KS, Pegan SD. The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference. Virology. 454: 247-53. PMID 24725951 DOI: 10.1016/J.Virol.2014.02.026  0.405
2014 Capodagli GC, Sedhom WG, Jackson M, Ahrendt KA, Pegan SD. A noncompetitive inhibitor for Mycobacterium tuberculosis's class IIa fructose 1,6-bisphosphate aldolase. Biochemistry. 53: 202-13. PMID 24325645 DOI: 10.1021/Bi401022B  0.745
2013 Capodagli GC, Deaton MK, Baker EA, Lumpkin RJ, Pegan SD. Diversity of ubiquitin and ISG15 specificity among nairoviruses' viral ovarian tumor domain proteases. Journal of Virology. 87: 3815-27. PMID 23345508 DOI: 10.1128/Jvi.03252-12  0.757
2013 Pegan SD, Rukseree K, Capodagli GC, Baker EA, Krasnykh O, Franzblau SG, Mesecar AD. Active site loop dynamics of a class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Biochemistry. 52: 912-25. PMID 23298222 DOI: 10.1021/Bi300928U  0.758
2012 Ray SP, Deaton MK, Capodagli GC, Calkins LA, Sawle L, Ghosh K, Patterson D, Pegan SD. Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation. Biochemistry. 51: 6701-13. PMID 22812634 DOI: 10.1021/Bi300796Y  0.718
2011 Connor SE, Capodagli GC, Deaton MK, Pegan SD. Structural and functional characterization of Mycobacterium tuberculosis triosephosphate isomerase. Acta Crystallographica. Section D, Biological Crystallography. 67: 1017-22. PMID 22120738 DOI: 10.1107/S0907444911042971  0.741
2011 Pegan SD, Sturdy M, Ferry G, Delagrange P, Boutin JA, Mesecar AD. X-ray structural studies of quinone reductase 2 nanomolar range inhibitors. Protein Science : a Publication of the Protein Society. 20: 1182-95. PMID 21538647 DOI: 10.1002/Pro.647  0.368
2011 Capodagli GC, McKercher MA, Baker EA, Masters EM, Brunzelle JS, Pegan SD. Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin. Journal of Virology. 85: 3621-30. PMID 21228232 DOI: 10.1128/Jvi.02496-10  0.754
2010 Burks EA, Fleming CD, Mesecar AD, Whitman CP, Pegan SD. Kinetic and structural characterization of a heterohexamer 4-oxalocrotonate tautomerase from Chloroflexus aurantiacus J-10-fl: implications for functional and structural diversity in the tautomerase superfamily . Biochemistry. 49: 5016-27. PMID 20465238 DOI: 10.1021/Bi100502Z  0.408
2009 Guo S, Tipparaju SK, Pegan SD, Wan B, Mo S, Orjala J, Mesecar AD, Franzblau SG, Kozikowski AP. Natural product leads for drug discovery: isolation, synthesis and biological evaluation of 6-cyano-5-methoxyindolo[2,3-a]carbazole based ligands as antibacterial agents. Bioorganic & Medicinal Chemistry. 17: 7126-30. PMID 19783449 DOI: 10.1016/J.Bmc.2009.08.061  0.357
2009 Maiti A, Reddy PV, Sturdy M, Marler L, Pegan SD, Mesecar AD, Pezzuto JM, Cushman M. Synthesis of casimiroin and optimization of its quinone reductase 2 and aromatase inhibitory activities. Journal of Medicinal Chemistry. 52: 1873-84. PMID 19265439 DOI: 10.1021/Jm801335Z  0.301
2009 Pegan SD, Rukseree K, Franzblau SG, Mesecar AD. Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis. Journal of Molecular Biology. 386: 1038-53. PMID 19167403 DOI: 10.1016/J.Jmb.2009.01.003  0.494
2008 Pegan SD, Serrano H, Whitman CP, Mesecar AD. Structural and mechanistic analysis of trans-3-chloroacrylic acid dehalogenase activity. Acta Crystallographica. Section D, Biological Crystallography. 64: 1277-82. PMID 19018104 DOI: 10.1107/S0907444908034707  0.436
2008 Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proceedings of the National Academy of Sciences of the United States of America. 105: 16119-24. PMID 18852458 DOI: 10.1073/Pnas.0805240105  0.434
2008 Tipparaju SK, Joyasawal S, Forrester S, Mulhearn DC, Pegan S, Johnson ME, Mesecar AD, Kozikowski AP. Design and synthesis of 2-pyridones as novel inhibitors of the Bacillus anthracis enoyl-ACP reductase. Bioorganic & Medicinal Chemistry Letters. 18: 3565-9. PMID 18499454 DOI: 10.1016/J.Bmcl.2008.05.004  0.307
2007 Pegan S, Tan J, Huang A, Slesinger PA, Riek R, Choe S. NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95. Biochemistry. 46: 5315-22. PMID 17437338 DOI: 10.1021/Bi062228Q  0.308
2006 Pegan S, Arrabit C, Slesinger PA, Choe S. Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Biochemistry. 45: 8599-606. PMID 16834334 DOI: 10.1021/Bi060653D  0.349
2005 Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nature Neuroscience. 8: 279-87. PMID 15723059 DOI: 10.1038/Nn1411  0.321
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