Martin J. Humphries, B.Sc., Ph.D. - Publications

Affiliations: 
Wellcome Trust Center for Cell-Matrix Research Manchester University, North Manchester, IN, United States 
Area:
Integrin structure and signaling

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lock JG, Baschieri F, Jones MC, Humphries JD, Montagnac G, Strömblad S, Humphries MJ. Clathrin-containing adhesion complexes. The Journal of Cell Biology. PMID 31208994 DOI: 10.1083/jcb.201811160  0.52
2018 Humphries JD, Chastney MR, Askari JA, Humphries MJ. Signal transduction via integrin adhesion complexes. Current Opinion in Cell Biology. 56: 14-21. PMID 30195153 DOI: 10.1016/j.ceb.2018.08.004  0.52
2018 Jones MC, Askari JA, Humphries JD, Humphries MJ. Cell adhesion is regulated by CDK1 during the cell cycle. The Journal of Cell Biology. PMID 29930204 DOI: 10.1083/jcb.201802088  0.52
2017 Robertson J, Humphries JD, Paul NR, Warwood S, Knight D, Byron A, Humphries MJ. Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1636: 235-251. PMID 28730483 DOI: 10.1007/978-1-4939-7154-1_15  0.52
2016 Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ. The integrin adhesome network at a glance. Journal of Cell Science. PMID 27799358 DOI: 10.1242/jcs.192054  0.52
2016 Mould AP, Askari JA, Byron A, Takada Y, Jowitt TA, Humphries MJ. Ligand-induced epitope masking. Dissociation of integrin α5β1-fibronectin complexes only by monoclonal antibodies with an allosteric mode of action. The Journal of Biological Chemistry. PMID 27484800 DOI: 10.1074/jbc.M116.736942  0.52
2016 Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. The Journal of Cell Biology. 212: 349-64. PMID 26833789 DOI: 10.1083/jcb.201508080  0.52
2015 Horton ER, Astudillo P, Humphries MJ, Humphries JD. Mechanosensitivity of integrin adhesion complexes: Role of the consensus adhesome. Experimental Cell Research. PMID 26515553 DOI: 10.1016/j.yexcr.2015.10.025  0.52
2015 Horton ER, Byron A, Askari JA, Ng DH, Millon-Frémillon A, Robertson J, Koper EJ, Paul NR, Warwood S, Knight D, Humphries JD, Humphries MJ. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly. Nature Cell Biology. PMID 26479319 DOI: 10.1038/ncb3257  0.52
2015 Ajeian JN, Horton ER, Astudillo P, Byron A, Askari JA, Millon-Frémillon A, Knight D, Kimber SJ, Humphries MJ, Humphries JD. Proteomic analysis of integrin-associated complexes from mesenchymal stem cells. Proteomics. Clinical Applications. PMID 26147903 DOI: 10.1002/prca.201500033  0.52
2015 Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, et al. Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization. Journal of the American Society of Nephrology : Jasn. PMID 25896609 DOI: 10.1681/ASN.2014040419  0.52
2015 Humphries JD, Paul NR, Humphries MJ, Morgan MR. Emerging properties of adhesion complexes: what are they and what do they do? Trends in Cell Biology. 25: 388-97. PMID 25824971 DOI: 10.1016/j.tcb.2015.02.008  0.52
2015 Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DH, Askari JA, Humphries MJ. Isolation of integrin-based adhesion complexes. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. 66: 9.8.1-9.8.15. PMID 25727331 DOI: 10.1002/0471143030.cb0908s66  0.52
2015 Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD, Humphries MJ. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nature Communications. 6: 6265. PMID 25677187 DOI: 10.1038/ncomms7265  0.52
2015 Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ. A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nature Communications. 6: 6135. PMID 25609142 DOI: 10.1038/ncomms7135  0.52
2014 Ng DH, Humphries JD, Byron A, Millon-Frémillon A, Humphries MJ. Microtubule-dependent modulation of adhesion complex composition. Plos One. 9: e115213. PMID 25526367 DOI: 10.1371/journal.pone.0115213  0.52
2014 Mould AP, Craig SE, Byron SK, Humphries MJ, Jowitt TA. Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors. The Biochemical Journal. 464: 301-13. PMID 25333419 DOI: 10.1042/BJ20141047  0.52
2014 Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. Journal of the American Society of Nephrology : Jasn. 25: 953-66. PMID 24436469 DOI: 10.1681/ASN.2013070795  0.52
2014 Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. Journal of the American Society of Nephrology : Jasn. 25: 939-51. PMID 24436468 DOI: 10.1681/ASN.2013030233  0.52
2013 Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. Journal of Cell Science. 126: 4121-35. PMID 23843620 DOI: 10.1242/jcs.121988  0.52
2013 Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S, Haddock MC, Baxter MA, Knight D, Humphries MJ, Kimber SJ. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. The Journal of Biological Chemistry. 288: 18716-31. PMID 23658023 DOI: 10.1074/jbc.M113.463372  0.52
2013 Byron A, Humphries JD, Humphries MJ. Defining the extracellular matrix using proteomics. International Journal of Experimental Pathology. 94: 75-92. PMID 23419153 DOI: 10.1111/iep.12011  0.52
2013 Kong F, Li Z, Parks WM, Dumbauld DW, García AJ, Mould AP, Humphries MJ, Zhu C. Cyclic mechanical reinforcement of integrin-ligand interactions. Molecular Cell. 49: 1060-8. PMID 23416109 DOI: 10.1016/j.molcel.2013.01.015  0.52
2012 Rashid ST, Humphries JD, Byron A, Dhar A, Askari JA, Selley JN, Knight D, Goldin RD, Thursz M, Humphries MJ. Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. Journal of Proteome Research. 11: 4052-64. PMID 22694338 DOI: 10.1021/pr3000927  0.52
2012 Byron A, Humphries JD, Craig SE, Knight D, Humphries MJ. Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics. 12: 2107-14. PMID 22623428 DOI: 10.1002/pmic.201100487  0.52
2012 Byron A, Humphries JD, Humphries MJ. Alternative cellular roles for proteins identified using proteomics. Journal of Proteomics. 75: 4184-5. PMID 22579753 DOI: 10.1016/j.jprot.2012.04.049  0.52
2011 Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ. A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Developmental Cell. 21: 681-93. PMID 21982645 DOI: 10.1016/j.devcel.2011.08.007  0.52
2011 Byron A, Humphries JD, Bass MD, Knight D, Humphries MJ. Proteomic analysis of integrin adhesion complexes. Science Signaling. 4: pt2. PMID 21467297 DOI: 10.1126/scisignal.2001827  0.52
2009 Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ. Anti-integrin monoclonal antibodies. Journal of Cell Science. 122: 4009-11. PMID 19910492 DOI: 10.1242/jcs.056770  0.52
2009 Mould AP, Koper EJ, Byron A, Zahn G, Humphries MJ. Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. The Biochemical Journal. 424: 179-89. PMID 19747169 DOI: 10.1042/BJ20090992  0.52
2009 Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science Signaling. 2: ra51. PMID 19738201 DOI: 10.1126/scisignal.2000396  0.52
2009 Kong F, García AJ, Mould AP, Humphries MJ, Zhu C. Demonstration of catch bonds between an integrin and its ligand. The Journal of Cell Biology. 185: 1275-84. PMID 19564406 DOI: 10.1083/jcb.200810002  0.52
2009 Deakin NO, Bass MD, Warwood S, Schoelermann J, Mostafavi-Pour Z, Knight D, Ballestrem C, Humphries MJ. An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. Journal of Cell Science. 122: 1654-64. PMID 19401330 DOI: 10.1242/jcs.049130  0.52
2009 Askari JA, Buckley PA, Mould AP, Humphries MJ. Linking integrin conformation to function. Journal of Cell Science. 122: 165-70. PMID 19118208 DOI: 10.1242/jcs.018556  0.52
2008 Valdramidou D, Humphries MJ, Mould AP. Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. The Journal of Biological Chemistry. 283: 32704-14. PMID 18820259 DOI: 10.1074/jbc.M802066200  0.52
2008 Parsons M, Messent AJ, Humphries JD, Deakin NO, Humphries MJ. Quantification of integrin receptor agonism by fluorescence lifetime imaging. Journal of Cell Science. 121: 265-71. PMID 18216331 DOI: 10.1242/jcs.018440  0.52
2007 Humphries JD, Wang P, Streuli C, Geiger B, Humphries MJ, Ballestrem C. Vinculin controls focal adhesion formation by direct interactions with talin and actin. The Journal of Cell Biology. 179: 1043-57. PMID 18056416 DOI: 10.1083/jcb.200703036  0.52
2007 Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ. The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 485-93. PMID 17490871 DOI: 10.1016/j.matbio.2007.04.001  0.52
2007 Bass MD, Roach KA, Morgan MR, Mostafavi-Pour Z, Schoen T, Muramatsu T, Mayer U, Ballestrem C, Spatz JP, Humphries MJ. Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. The Journal of Cell Biology. 177: 527-38. PMID 17485492 DOI: 10.1083/jcb.200610076  0.52
2007 Humphries JD, Humphries MJ. CD14 is a ligand for the integrin alpha4beta1. Febs Letters. 581: 757-63. PMID 17274987 DOI: 10.1016/j.febslet.2007.01.038  0.52
2006 Wijelath ES, Rahman S, Namekata M, Murray J, Nishimura T, Mostafavi-Pour Z, Patel Y, Suda Y, Humphries MJ, Sobel M. Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circulation Research. 99: 853-60. PMID 17008606 DOI: 10.1161/01.RES.0000246849.17887.66  0.52
2006 Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. Journal of Cell Science. 119: 3901-3. PMID 16988024 DOI: 10.1242/jcs.03098  0.52
2006 Sumathipala R, Xu C, Seago J, Mould AP, Humphries MJ, Craig SE, Patel Y, Wijelath ES, Sobel M, Rahman S. The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity. The Journal of Biological Chemistry. 281: 37686-96. PMID 16982624 DOI: 10.1074/jbc.M603943200  0.52
2006 Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ. Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio). Bmc Cell Biology. 7: 24. PMID 16787535 DOI: 10.1186/1471-2121-7-24  0.52
2005 Humphries MJ, Mostafavi-Pour Z, Morgan MR, Deakin NO, Messent AJ, Bass MD. Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading. Novartis Foundation Symposium. 269: 178-88; discussion 1. PMID 16355540  0.52
2005 Gläsner J, Blum H, Wehner V, Stilz HU, Humphries JD, Curley GP, Mould AP, Humphries MJ, Hallmann R, Röllinghoff M, Gessner A. A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity. Journal of Immunology (Baltimore, Md. : 1950). 175: 4724-34. PMID 16177120  0.52
2005 Meng X, Cheng K, Krohkin O, Mould AP, Humphries MJ, Ens W, Standing K, Wilkins JA. Evidence for the presence of a low-mass beta1 integrin on the cell surface. Journal of Cell Science. 118: 4009-16. PMID 16105875 DOI: 10.1242/jcs.02520  0.52
2005 Ewan R, Huxley-Jones J, Mould AP, Humphries MJ, Robertson DL, Boot-Handford RP. The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. Bmc Evolutionary Biology. 5: 31. PMID 15892888 DOI: 10.1186/1471-2148-5-31  0.52
2005 Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ. Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors. The Journal of Biological Chemistry. 280: 10234-43. PMID 15632175 DOI: 10.1074/jbc.M411102200  1
2005 Clark K, Pankov R, Travis MA, Askari JA, Mould AP, Craig SE, Newham P, Yamada KM, Humphries MJ. A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. Journal of Cell Science. 118: 291-300. PMID 15615773 DOI: 10.1242/jcs.01623  0.52
2005 Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, Macdonald PR, Kammerer RA, Buckley PA, Humphries MJ. Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. The Journal of Biological Chemistry. 280: 4238-46. PMID 15557320 DOI: 10.1074/jbc.M412240200  0.52
2004 Mould AP, Humphries MJ. Cell biology: adhesion articulated. Nature. 432: 27-8. PMID 15525967 DOI: 10.1038/432027a  0.52
2004 Humphries MJ, Travis MA, Clark K, Mould AP. Mechanisms of integration of cells and extracellular matrices by integrins. Biochemical Society Transactions. 32: 822-5. PMID 15494024 DOI: 10.1042/BST0320822  0.52
2004 Mould AP, Humphries MJ. Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Current Opinion in Cell Biology. 16: 544-51. PMID 15363805 DOI: 10.1016/j.ceb.2004.07.003  0.52
2004 Travis MA, van der Flier A, Kammerer RA, Mould AP, Sonnenberg A, Humphries MJ. Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation. Febs Letters. 569: 185-90. PMID 15225631 DOI: 10.1016/j.febslet.2004.04.099  0.52
2004 Barton SJ, Travis MA, Askari JA, Buckley PA, Craig SE, Humphries MJ, Mould AP. Novel activating and inactivating mutations in the integrin beta1 subunit A domain. The Biochemical Journal. 380: 401-7. PMID 14967067 DOI: 10.1042/BJ20031973  0.52
2003 Mould AP, Barton SJ, Askari JA, Craig SE, Humphries MJ. Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. The Journal of Biological Chemistry. 278: 51622-9. PMID 14532288 DOI: 10.1074/jbc.M306655200  0.52
2003 Mould AP, Symonds EJ, Buckley PA, Grossmann JG, McEwan PA, Barton SJ, Askari JA, Craig SE, Bella J, Humphries MJ. Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. The Journal of Biological Chemistry. 278: 39993-9. PMID 12871973 DOI: 10.1074/jbc.M304627200  0.52
2003 Humphries MJ, McEwan PA, Barton SJ, Buckley PA, Bella J, Mould AP. Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble. Trends in Biochemical Sciences. 28: 313-20. PMID 12826403 DOI: 10.1016/S0968-0004(03)00112-9  0.52
2003 Humphries MJ, Symonds EJ, Mould AP. Mapping functional residues onto integrin crystal structures. Current Opinion in Structural Biology. 13: 236-43. PMID 12727518  0.52
2003 Travis MA, Humphries JD, Humphries MJ. An unraveling tale of how integrins are activated from within. Trends in Pharmacological Sciences. 24: 192-7. PMID 12707006 DOI: 10.1016/S0165-6147(03)00069-5  0.52
2003 Mostafavi-Pour Z, Askari JA, Parkinson SJ, Parker PJ, Ng TT, Humphries MJ. Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. The Journal of Cell Biology. 161: 155-67. PMID 12695503 DOI: 10.1083/jcb.200210176  0.52
2003 Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, Humphries MJ. Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. The Journal of Biological Chemistry. 278: 17028-35. PMID 12615914 DOI: 10.1074/jbc.M213139200  0.52
2002 Whittard JD, Craig SE, Mould AP, Koch A, Pertz O, Engel J, Humphries MJ. E-cadherin is a ligand for integrin alpha2beta1. Matrix Biology : Journal of the International Society For Matrix Biology. 21: 525-32. PMID 12392763 DOI: 10.1016/S0945-053X(02)00037-9  0.52
2002 Mould AP, Askari JA, Barton S, Kline AD, McEwan PA, Craig SE, Humphries MJ. Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. The Journal of Biological Chemistry. 277: 19800-5. PMID 11893752 DOI: 10.1074/jbc.M201571200  0.52
2001 Humphries MJ, Mould AP. Structure. An anthropomorphic integrin. Science (New York, N.Y.). 294: 316-7. PMID 11598288 DOI: 10.1126/science.1066240  0.52
2001 Mostafavi-Pour Z, Askari JA, Whittard JD, Humphries MJ. Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants. Matrix Biology : Journal of the International Society For Matrix Biology. 20: 63-73. PMID 11246004  0.52
2000 Jackson T, Blakemore W, Newman JW, Knowles NJ, Mould AP, Humphries MJ, King AM. Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding. The Journal of General Virology. 81: 1383-91. PMID 10769082  0.52
2000 Mould AP, Askari JA, Humphries MJ. Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit. The Journal of Biological Chemistry. 275: 20324-36. PMID 10764748 DOI: 10.1074/jbc.M000572200  0.52
2000 Humphries JD, Askari JA, Zhang XP, Takada Y, Humphries MJ, Mould AP. Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit. The Journal of Biological Chemistry. 275: 20337-45. PMID 10764747 DOI: 10.1074/jbc.M000568200  0.52
1999 Burrows L, Clark K, Mould AP, Humphries MJ. Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding. The Biochemical Journal. 344: 527-33. PMID 10567237  0.52
1998 Mould AP, Burrows L, Humphries MJ. Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1. The Journal of Biological Chemistry. 273: 25664-72. PMID 9748233  0.52
1998 Fernandez C, Clark K, Burrows L, Schofield NR, Humphries MJ. Regulation of the extracellular ligand binding activity of integrins. Frontiers in Bioscience : a Journal and Virtual Library. 3: d684-700. PMID 9637803  0.52
1998 Green LJ, Mould AP, Humphries MJ. The integrin beta subunit. The International Journal of Biochemistry & Cell Biology. 30: 179-84. PMID 9608671  0.52
1998 Newham P, Craig SE, Clark K, Mould AP, Humphries MJ. Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes. Journal of Immunology (Baltimore, Md. : 1950). 160: 4508-17. PMID 9574557  0.52
1998 Mould AP, Garratt AN, Puzon-McLaughlin W, Takada Y, Humphries MJ. Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1. The Biochemical Journal. 331: 821-8. PMID 9560310  1
1997 Tselepis VH, Green LJ, Humphries MJ. An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs. The Journal of Biological Chemistry. 272: 21341-8. PMID 9261147  0.52
1997 Newham P, Craig SE, Seddon GN, Schofield NR, Rees A, Edwards RM, Jones EY, Humphries MJ. Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity. The Journal of Biological Chemistry. 272: 19429-40. PMID 9235944 DOI: 10.1074/jbc.272.31.19429  0.52
1997 Mould AP, Askari JA, Aota Si, Yamada KM, Irie A, Takada Y, Mardon HJ, Humphries MJ. Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit. The Journal of Biological Chemistry. 272: 17283-92. PMID 9211865  0.52
1996 Schor SL, Ellis I, Dolman C, Banyard J, Humphries MJ, Mosher DF, Grey AM, Mould AP, Sottile J, Schor AM. Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin. Journal of Cell Science. 109: 2581-90. PMID 8923219  0.52
1996 Mould AP, Akiyama SK, Humphries MJ. The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function. The Journal of Biological Chemistry. 271: 20365-74. PMID 8702772  0.52
1996 Frankel G, Lider O, Hershkoviz R, Mould AP, Kachalsky SG, Candy DC, Cahalon L, Humphries MJ, Dougan G. The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins. The Journal of Biological Chemistry. 271: 20359-64. PMID 8702771  0.52
1996 Chambers MA, Dougan G, Newman J, Brown F, Crowther J, Mould AP, Humphries MJ, Francis MJ, Clarke B, Brown AL, Rowlands D. Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions. Journal of Virology. 70: 4045-52. PMID 8648742  0.52
1995 Garratt AN, Humphries MJ. Recent insights into ligand binding, activation and signalling by integrin adhesion receptors. Acta Anatomica. 154: 34-45. PMID 8714288  1
1995 Green LJ, Brierley VH, Humphries MJ. Inhibition of integrin-ligand binding by recombinant kistrins. Biochemical Society Transactions. 23: 505S. PMID 8654690  0.52
1995 Mould AP, Garratt AN, Askari JA, Akiyama SK, Humphries MJ. Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations. Biochemical Society Transactions. 23: 395S. PMID 8566283  1
1995 Tuckwell D, Calderwood DA, Green LJ, Humphries MJ. Integrin alpha 2 I-domain is a binding site for collagens. Journal of Cell Science. 108: 1629-37. PMID 7615681  0.52
1995 Mould AP, Akiyama SK, Humphries MJ. Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+. The Journal of Biological Chemistry. 270: 26270-7. PMID 7592835  0.52
1995 Humphries MJ, Sheridan J, Mould AP, Newham P. Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design. Ciba Foundation Symposium. 189: 177-91; discussion 1. PMID 7587632  0.52
1995 Mould AP, Garratt AN, Askari JA, Akiyama SK, Humphries MJ. Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit. Febs Letters. 363: 118-22. PMID 7537221 DOI: 10.1016/0014-5793(95)00301-O  1
1994 Dudgeon TJ, Bottomley MJ, Driscoll PC, Humphries MJ, Mould AP, Wingfield GI, Clements JM. Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1. European Journal of Biochemistry / Febs. 226: 517-23. PMID 7528140  0.52
1994 Mould AP, Askari JA, Craig SE, Garratt AN, Clements J, Humphries MJ. Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin. The Journal of Biological Chemistry. 269: 27224-30. PMID 7525548  1
1994 Weston SA, Hulmes DJ, Mould AP, Watson RB, Humphries MJ. Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen. The Journal of Biological Chemistry. 269: 20982-6. PMID 7520435  0.52
1994 Makarem R, Newham P, Askari JA, Green LJ, Clements J, Edwards M, Humphries MJ, Mould AP. Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1. The Journal of Biological Chemistry. 269: 4005-11. PMID 7508437  0.52
1993 Humphries MJ, Mould AP, Tuckwell DS. Dynamic aspects of adhesion receptor function--integrins both twist and shout. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 15: 391-7. PMID 8357341 DOI: 10.1002/bies.950150605  0.52
1991 Komoriya A, Green LJ, Mervic M, Yamada SS, Yamada KM, Humphries MJ. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. The Journal of Biological Chemistry. 266: 15075-9. PMID 1869542  0.52
1991 Mould AP, Askari JA, Akiyama SK, Yamada KM, Humphries MJ. An assessment of the efficacy of anti-integrin alpha subunit monoclonal antibody production using affinity purified beta 1-integrin dimers as immunogen. Biochemical Society Transactions. 19: 361S. PMID 1794496  0.52
1991 Mould AP, Humphries MJ. Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin. The Embo Journal. 10: 4089-95. PMID 1756719  0.52
1991 Mould AP, Komoriya A, Yamada KM, Humphries MJ. The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues. The Journal of Biological Chemistry. 266: 3579-85. PMID 1750929  0.52
1990 Mould AP, Wheldon LA, Komoriya A, Wayner EA, Yamada KM, Humphries MJ. Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1. The Journal of Biological Chemistry. 265: 4020-4. PMID 2137460  0.52
1990 Nojima Y, Humphries MJ, Mould AP, Komoriya A, Yamada KM, Schlossman SF, Morimoto C. VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. The Journal of Experimental Medicine. 172: 1185-92. PMID 1976737  0.52
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