Juan C. Troncoso, MD - Publications

Pathology Johns Hopkins University School of Medicine, Baltimore, MD, United States 
human neurodegenerative disorders, in particular Alzheimer's disease

243 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stein-O'Brien GL, Palaganas R, Meyer EM, Redding-Ochoa J, Pletnikova O, Guo H, Bell WR, Troncoso JC, Huganir RL, Morris M. Transcriptional Signatures of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer's Disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37745408 DOI: 10.1101/2023.09.12.23295440  0.311
2023 Jury-Garfe N, You Y, Martínez P, Redding-Ochoa J, Karahan H, Johnson TS, Zhang J, Kim J, Troncoso JC, Lasagna-Reeves CA. Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 37546928 DOI: 10.1101/2023.07.27.550884  0.323
2023 Chen C, Kumbhar R, Wang H, Yang X, Gadhave K, Rastegar C, Kimura Y, Behensky A, Katakam S, Jeong D, Wang L, Wang A, Chen R, Zhang S, Jin L, ... ... Troncoso JC, et al. Pathological Tau transmission initiated by binding lymphocyte-activation gene 3. Biorxiv : the Preprint Server For Biology. PMID 37293032 DOI: 10.1101/2023.05.16.541015  0.32
2022 Kim DW, Tu KJ, Wei A, Lau AJ, Gonzalez-Gil A, Cao T, Braunstein K, Ling JP, Troncoso JC, Wong PC, Blackshaw S, Schnaar RL, Li T. Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes. Molecular Neurodegeneration. 17: 83. PMID 36536457 DOI: 10.1186/s13024-022-00589-x  0.306
2021 Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Troncoso JC, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z  0.309
2020 Huang Y, Cheng L, Turchinovich A, Mahairaki V, Troncoso JC, Pletniková O, Haughey NJ, Vella LJ, Hill AF, Zheng L, Witwer KW. Influence of species and processing parameters on recovery and content of brain tissue-derived extracellular vesicles. Journal of Extracellular Vesicles. 9: 1785746. PMID 32944174 DOI: 10.1080/20013078.2020.1785746  0.301
2020 Sathe G, Albert M, Darrow J, Saito A, Troncoso J, Pandey A, Moghekar A. Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease. Journal of Neurochemistry. PMID 32614981 DOI: 10.1111/Jnc.15116  0.407
2020 Wingo AP, Fan W, Duong DM, Gerasimov ES, Dammer EB, Liu Y, Harerimana NV, White B, Thambisetty M, Troncoso JC, Kim N, Schneider JA, Hajjar IM, Lah JJ, Bennett DA, et al. Publisher Correction: Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. Nature Neuroscience. PMID 32576978 DOI: 10.1038/S41593-020-0662-2  0.355
2020 Wingo AP, Fan W, Duong DM, Gerasimov ES, Dammer EB, Liu Y, Harerimana NV, White B, Thambisetty M, Troncoso JC, Kim N, Schneider JA, Hajjar IM, Lah JJ, Bennett DA, et al. Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain. Nature Neuroscience. PMID 32424284 DOI: 10.1038/S41593-020-0635-5  0.354
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/S41591-020-0815-6  0.409
2020 Jiang M, Zhang X, Liu H, LeBron J, Alexandris A, Peng Q, Gu H, Yang F, Li Y, Wang R, Hou Z, Arbez N, Ren Q, Dong JL, Whela E, ... ... Troncoso JC, et al. Nemo-like Kinase Reduces Mutant Huntingtin Levels and Mitigates Huntington's Disease. Human Molecular Genetics. PMID 32242231 DOI: 10.1093/Hmg/Ddaa061  0.332
2020 Sathe G, Mangalaparthi KK, Jain A, Darrow J, Troncoso J, Albert M, Moghekar A, Pandey A. Multiplexed Phosphoproteomic Study of Brain in Patients with Alzheimer's Disease and Age-Matched Cognitively Healthy Controls. Omics : a Journal of Integrative Biology. PMID 32182160 DOI: 10.1089/Omi.2019.0191  0.425
2020 Allnutt MA, Johnson K, Bennett DA, Connor SM, Troncoso JC, Pletnikova O, Albert MS, Resnick SM, Scholz SW, De Jager PL, Jacobson S. Human Herpesvirus 6 Detection in Alzheimer's Disease Cases and Controls across Multiple Cohorts. Neuron. PMID 31983538 DOI: 10.1016/J.Neuron.2019.12.031  0.361
2020 Mahajan UV, Varma VR, Griswold ME, Blackshear CT, An Y, Oommen AM, Varma S, Troncoso JC, Pletnikova O, O'Brien R, Hohman TJ, Legido-Quigley C, Thambisetty M. Dysregulation of multiple metabolic networks related to brain transmethylation and polyamine pathways in Alzheimer disease: A targeted metabolomic and transcriptomic study. Plos Medicine. 17: e1003012. PMID 31978055 DOI: 10.1371/Journal.Pmed.1003012  0.381
2020 Panicker N, Kam T, Neifert S, Hinkle J, Mao X, Karuppagounder S, Wang H, Kumar M, Pirooznia S, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. NLRP3 inflammasome activation in dopamine neurons contributes to neurodegeneration in Parkinson’s Disease The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01881  0.311
2019 Blauwendraat C, Reed X, Krohn L, Heilbron K, Bandres-Ciga S, Tan M, Gibbs JR, Hernandez DG, Kumaran R, Langston R, Bonet-Ponce L, Alcalay RN, Hassin-Baer S, Greenbaum L, Iwaki H, ... ... Troncoso J, et al. Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia. Brain : a Journal of Neurology. PMID 31755958 DOI: 10.1093/Brain/Awz350  0.349
2019 Snowden SG, Ebshiana AA, Hye A, Pletnikova O, O'Brien R, Yang A, Troncoso J, Legido-Quigley C, Thambisetty M. Neurotransmitter Imbalance in the Brain and Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 31561368 DOI: 10.3233/Jad-190577  0.419
2019 Ahmed S, Fairen MD, Sabir MS, Pastor P, Ding J, Ispierto L, Butala A, Morris CM, Schulte C, Gasser T, Jabbari E, Pletnikova O, Morris HR, Troncoso J, Gelpi E, et al. p.V363I mutation: A rare cause of corticobasal degeneration. Neurology. Genetics. 5: e347. PMID 31404212 DOI: 10.1212/Nxg.0000000000000347  0.334
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/S00401-019-02045-5  0.391
2019 van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, ... ... Troncoso J, et al. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. Acta Neuropathologica. PMID 31131421 DOI: 10.1007/S00401-019-02026-8  0.369
2019 Guerreiro R, Escott-Price V, Hernandez DG, Kun-Rodrigues C, Ross OA, Orme T, Neto JL, Carmona S, Dehghani N, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, ... Troncoso JC, et al. Heritability and genetic variance of dementia with Lewy bodies. Neurobiology of Disease. PMID 30953760 DOI: 10.1016/J.Nbd.2019.04.004  0.331
2019 Hishimoto A, Pletnikova O, Lang DL, Troncoso JC, Egan JM, Liu QR. Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease. Alzheimer's Research & Therapy. 11: 28. PMID 30902061 DOI: 10.1186/S13195-019-0475-2  0.405
2019 Sabir MS, Blauwendraat C, Ahmed S, Serrano GE, Beach TG, Perkins M, Rice AC, Masliah E, Morris CM, Pihlstrom L, Pantelyat A, Resnick SM, Cookson MR, Hernandez DG, Albert M, ... ... Troncoso J, et al. Assessment of APOE in atypical parkinsonism syndromes. Neurobiology of Disease. PMID 30798004 DOI: 10.1016/J.Nbd.2019.02.016  0.364
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Troncoso J, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.378
2019 Horti AG, Naik R, Foss CA, Minn I, Misheneva V, Du Y, Wang Y, Mathews WB, Wu Y, Hall A, LaCourse C, Ahn HH, Nam H, Lesniak WG, Valentine H, ... ... Troncoso JC, et al. PET imaging of microglia by targeting macrophage colony-stimulating factor 1 receptor (CSF1R). Proceedings of the National Academy of Sciences of the United States of America. PMID 30635412 DOI: 10.1073/Pnas.1812155116  0.368
2019 Johnson ECB, Dammer EB, Duong D, Yin L, Thambisetty M, Troncoso JC, Lah JJ, Levey AI, Seyfried NT. P2-218: Deep Proteomic Network Analysis Of Alzheimer'S Disease Brain Reveals Alterations In Rna Binding Proteins And Rna Splicing Associated With Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2625  0.329
2018 Blauwendraat C, Pletnikova O, Geiger JT, Murphy NA, Abramzon Y, Rudow G, Mamais A, Sabir MS, Crain B, Ahmed S, Rosenthal LS, Bakker CC, Faghri F, Chia R, Ding J, ... ... Troncoso JC, et al. Genetic analysis of neurodegenerative diseases in a pathology cohort. Neurobiology of Aging. PMID 30528841 DOI: 10.1016/J.Neurobiolaging.2018.11.007  0.321
2018 Bell WR, An Y, Kageyama Y, English C, Rudow GL, Pletnikova O, Thambisetty M, O'Brien R, Moghekar AR, Albert MS, Rabins PV, Resnick SM, Troncoso JC. Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30465754 DOI: 10.1016/J.Jalz.2018.07.215  0.389
2018 Kun-Rodrigues C, Orme T, Carmona S, Hernandez DG, Ross OA, Eicher JD, Shepherd C, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Dawson T, Rosenthal L, et al. A comprehensive screening of copy number variability in dementia with Lewy bodies. Neurobiology of Aging. PMID 30448004 DOI: 10.1016/J.Neurobiolaging.2018.10.019  0.33
2018 Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Scientific Reports. 8: 16895. PMID 30442978 DOI: 10.1038/S41598-018-35004-3  0.371
2018 Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, et al. Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease. Science (New York, N.Y.). 362. PMID 30385548 DOI: 10.1126/Science.Aat8407  0.307
2018 Johnson ECB, Dammer EB, Duong DM, Yin L, Thambisetty M, Troncoso JC, Lah JJ, Levey AI, Seyfried NT. Deep proteomic network analysis of Alzheimer's disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease. Molecular Neurodegeneration. 13: 52. PMID 30286791 DOI: 10.1186/S13024-018-0282-4  0.425
2018 Oh ES, Blennow K, Bigelow GE, Inouye SK, Marcantonio ER, Neufeld KJ, Rosenberg PB, Troncoso JC, Wang NY, Zetterberg H, Sieber FE, Lyketsos CG. Abnormal CSF amyloid-β42 and tau levels in hip fracture patients without dementia. Plos One. 13: e0204695. PMID 30252906 DOI: 10.1371/Journal.Pone.0204695  0.348
2018 Ayhan F, Perez BA, Shorrock HK, Zu T, Banez-Coronel M, Reid T, Furuya H, Clark HB, Troncoso JC, Ross CA, Subramony SH, Ashizawa T, Wang ET, Yachnis AT, Ranum LP. SCA8 RAN polySer protein preferentially accumulates in white matter regions and is regulated by eIF3F. The Embo Journal. PMID 30206144 DOI: 10.15252/Embj.201899023  0.354
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Troncoso J, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.427
2018 Pletnikova O, Kageyama Y, Rudow G, LaClair KD, Albert M, Crain BJ, Tian J, Fowler D, Troncoso JC. The spectrum of preclinical Alzheimer's disease pathology and its modulation by ApoE genotype. Neurobiology of Aging. 71: 72-80. PMID 30099348 DOI: 10.1016/J.Neurobiolaging.2018.07.007  0.363
2018 Varma VR, Oommen AM, Varma S, Casanova R, An Y, Andrews RM, O'Brien R, Pletnikova O, Troncoso JC, Toledo J, Baillie R, Arnold M, Kastenmueller G, Nho K, Doraiswamy PM, et al. Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study. Plos Medicine. 15: e1002482. PMID 29370177 DOI: 10.1371/Journal.Pmed.1002482  0.397
2018 Guerreiro R, Ross OA, Kun-Rodrigues C, Hernandez DG, Orme T, Eicher JD, Shepherd CE, Parkkinen L, Darwent L, Heckman MG, Scholz SW, Troncoso JC, Pletnikova O, Ansorge O, Clarimon J, et al. Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study. The Lancet. Neurology. 17: 64-74. PMID 29263008 DOI: 10.1016/S1474-4422(17)30400-3  0.33
2018 Varma VR, Oommenn A, An Y, Huang C, Wahrheit J, Pletnikova O, Troncoso JC, O'Brien R, Legido-Quigley C, Resnick SM, Thambisetty M. P2-276: Brain And Blood Oxysterol Metabolism Are Related To Alzheimer'S Disease Pathogenesis Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.965  0.357
2017 Todd KL, Brighton T, Norton ES, Schick S, Elkins W, Pletnikova O, Fortinsky RH, Troncoso JC, Molfese PJ, Resnick SM, Conover JC. Ventricular and Periventricular Anomalies in the Aging and Cognitively Impaired Brain. Frontiers in Aging Neuroscience. 9: 445. PMID 29379433 DOI: 10.3389/Fnagi.2017.00445  0.344
2017 Kim H, Ham S, Lee JY, Jo A, Lee GH, Lee YS, Cho M, Shin HM, Kim D, Pletnikova O, Troncoso JC, Shin JH, Lee YI, Lee Y. Estrogen receptor activation contributes to RNF146 expression and neuroprotection in Parkinson's disease models. Oncotarget. 8: 106721-106739. PMID 29290984 DOI: 10.18632/Oncotarget.21828  0.301
2017 Chiang ACA, Fowler SW, Reddy R, Pletnikova O, Troncoso JC, Sherman MA, Lesne SE, Jankowsky JL. Discrete pools of oligomeric amyloid-β track with spatial learning deficits in a mouse model of Alzheimer amyloidosis. The American Journal of Pathology. PMID 29248459 DOI: 10.1016/J.Ajpath.2017.11.011  0.354
2017 An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey A, Lah J, Seyfried N, Legido-Quigley C, O'Brien R, et al. Evidence for brain glucose dysregulation in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29055815 DOI: 10.1016/J.Jalz.2017.09.011  0.391
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Troncoso JC, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.341
2017 Castillo-Carranza DL, Nilson AN, Van Skike CE, Jahrling JB, Patel K, Garach P, Gerson JE, Sengupta U, Abisambra J, Nelson P, Troncoso J, Ungvari Z, Galvan V, Kayed R. Cerebral Microvascular Accumulation of Tau Oligomers in Alzheimer's Disease and Related Tauopathies. Aging and Disease. 8: 257-266. PMID 28580182 DOI: 10.14336/Ad.2017.0112  0.423
2017 Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, ... ... Troncoso JC, et al. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife. 6. PMID 28440221 DOI: 10.7554/Elife.23798  0.392
2017 Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, ... Troncoso JC, et al. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 94: 93-107.e6. PMID 28384479 DOI: 10.1016/J.Neuron.2017.03.023  0.322
2017 Sun M, Bell W, LaClair KD, Ling JP, Han H, Kageyama Y, Pletnikova O, Troncoso JC, Wong PC, Chen LL. Cryptic exon incorporation occurs in Alzheimer's brain lacking TDP-43 inclusion but exhibiting nuclear clearance of TDP-43. Acta Neuropathologica. PMID 28332094 DOI: 10.1007/S00401-017-1701-2  0.42
2017 Galasko DR, Xiao M, Xu D, Zhang J, Craig MT, Pelkey K, Resnick SM, Troncoso JC, Reeves R, McBain C, Salmon DP, Brewer JB, Edland SD, Worley PF. NEURONAL PENTRAXIN 2 (NPTX2): A SYNAPTIC BIOMARKER OF COGNITIVE DYSFUNCTION IN ALZHEIMER’S DISEASE Alzheimer's & Dementia. 13: P1231-P1232. DOI: 10.1016/J.Jalz.2017.07.429  0.319
2017 Seyfried NT, Dammer EB, Duong DM, Deng Q, Troncoso JC, Thambisetty M, Lah JJ, Levey AI. PROTEIN CO-EXPRESSION NETWORK ANALYSIS IN ASYMPTOMATIC AND SYMPTOMATIC ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P554-P555. DOI: 10.1016/J.Jalz.2017.07.155  0.344
2017 Varma VR, Oommenn A, Varma S, Casanova R, An Y, Andrews R, o'Brien R, Pletnikova O, Troncoso JC, Legido-Quigley C, Thambisetty M. The Endophenotype Association Score In Early Alzheimer’S Disease (Ease-Ad): Discovering Novel Blood And Brain Metabolite Signatures Of Pathology And Progression Alzheimers & Dementia. 13: 1015. DOI: 10.1016/J.Jalz.2017.06.1420  0.393
2016 Seyfried NT, Dammer EB, Swarup V, Nandakumar D, Duong DM, Yin L, Deng Q, Nguyen T, Hales CM, Wingo T, Glass J, Gearing M, Thambisetty M, Troncoso JC, Geschwind DH, et al. A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. Cell Systems. PMID 27989508 DOI: 10.1016/J.Cels.2016.11.006  0.389
2016 Blauwendraat C, Nalls MA, Federoff M, Pletnikova O, Ding J, Letson C, Geiger JT, Gibbs JR, Hernandez DG, Troncoso JC, Simón-Sánchez J, Scholz SW. ADORA1 mutations are not a common cause of Parkinson's disease and dementia with Lewy bodies. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 27987235 DOI: 10.1002/Mds.26886  0.332
2016 Varma VR, Varma S, An Y, Hohman TJ, Seddighi S, Casanova R, Beri A, Dammer EB, Seyfried NT, Pletnikova O, Moghekar A, Wilson MR, Lah JJ, O'Brien RJ, Levey AI, ... Troncoso JC, et al. Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. Molecular Psychiatry. PMID 27872486 DOI: 10.1038/Mp.2016.206  0.439
2016 Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, et al. TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife. 5. PMID 27779468 DOI: 10.7554/Elife.19809  0.39
2016 Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, et al. Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model. Neuron. PMID 27720485 DOI: 10.1016/J.Neuron.2016.09.022  0.405
2016 Hales CM, Dammer EB, Deng Q, Duong DM, Gearing M, Troncoso JC, Thambisetty M, Lah JJ, Shulman JM, Levey AI, Seyfried NT. Changes in the detergent-insoluble brain proteome linked to amyloid and tau in Alzheimer's Disease progression. Proteomics. PMID 27718298 DOI: 10.1002/Pmic.201600057  0.415
2016 Ratovitski T, Chaerkady R, Kammers K, Stewart JC, Zavala A, Pletnikova O, Troncoso JC, Rudnicki DD, Margolis RL, Cole RN, Ross CA. Quantitative Proteomic Analysis Reveals Similarities between Huntington's Disease (HD) and Huntington's Disease-Like 2 (HDL2) Human Brains. Journal of Proteome Research. PMID 27486686 DOI: 10.1021/Acs.Jproteome.6B00448  0.354
2016 Lin L, Park JW, Ramachandran S, Zhang Y, Tseng YT, Shen S, Waldvogel HJ, Curtis MA, Faull RL, Troncoso JC, Ross CA, Davidson BL, Xing Y. Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease. Human Molecular Genetics. PMID 27378699 DOI: 10.1093/Hmg/Ddw187  0.345
2016 Geiger JT, Ding J, Crain B, Pletnikova O, Letson C, Dawson TM, Rosenthal LS, Pantelyat A, Gibbs JR, Albert MS, Hernandez DG, Hillis AE, Stone DJ, Singleton AB, ... ... Troncoso JC, et al. Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies. Neurobiology of Disease. PMID 27312774 DOI: 10.1016/J.Nbd.2016.06.004  0.317
2016 Nucifora FC, Nucifora LG, Ng CH, Arbez N, Guo Y, Roby E, Shani V, Engelender S, Wei D, Wang XF, Li T, Moore DJ, Pletnikova O, Troncoso JC, Sawa A, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nature Communications. 7: 11792. PMID 27273569 DOI: 10.1038/Ncomms11792  0.302
2016 Tabbarah AZ, Robert Bell W, Sun M, Gelwan E, Pletnikova O, Hillis AE, Troncoso JC, Lin MT, Chen L. A rapidly progressive dementia case with pathological diagnosis of FTLD-UPS. Acta Neuropathologica. PMID 27271575 DOI: 10.1007/S00401-016-1584-7  0.317
2016 Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH. Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. Journal of Neurochemistry. PMID 27246255 DOI: 10.1111/Jnc.13688  0.405
2016 Geiger JT, Arthur KC, Dawson TM, Rosenthal LS, Pantelyat A, Albert M, Hillis AE, Crain B, Pletnikova O, Troncoso JC, Scholz SW. C9orf72 Hexanucleotide Repeat Analysis in Cases with Pathologically Confirmed Dementia with Lewy Bodies. Neuro-Degenerative Diseases. 16: 370-372. PMID 27241037 DOI: 10.1159/000445872  0.334
2016 McCutcheon ST, Han D, Troncoso J, Koliatsos VE, Albert M, Lyketsos CG, Leoutsakos JS. Clinicopathological correlates of depression in early Alzheimer's disease in the NACC. International Journal of Geriatric Psychiatry. PMID 26876501 DOI: 10.1002/Gps.4435  0.351
2016 Varma VR, Varma S, An Y, Beri A, Dammer EB, Seyfried NT, Moghekar A, Wilson M, Lah JJ, O’Brien R, Levey AI, Troncoso JC, Albert MS, Thambisetty M. The Acute Phase Protein Alpha-2-Macroglobulin Predicts Risk Of Incident Alzheimer'S Disease And Modulates Tau Pathology Through The Rcan1-Calcineurin Pathway Alzheimers & Dementia. 12: 745. DOI: 10.1016/J.Jalz.2016.06.1554  0.34
2016 Thambisetty M, Varma S, Casanova R, An Y, Pletnikova O, O'Brien R, Troncoso JC, Quigley CL. Brain And Blood Metabolite Signatures Of Pathology And Progression In Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1312  0.339
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Troncoso JC, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/S00401-015-1509-X  0.369
2015 Levy BR, Ferrucci L, Zonderman AB, Slade MD, Troncoso J, Resnick SM. A Culture-Brain Link: Negative Age Stereotypes Predict Alzheimer's Disease Biomarkers. Psychology and Aging. PMID 26641877 DOI: 10.1037/Pag0000062  0.382
2015 Choi S, Kim D, Kam TI, Yun S, Kim S, Park H, Hwang H, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Ko HS. Lysosomal Enzyme Glucocerebrosidase Protects against Aβ1-42 Oligomer-Induced Neurotoxicity. Plos One. 10: e0143854. PMID 26629917 DOI: 10.1371/Journal.Pone.0143854  0.42
2015 Bañez-Coronel M, Ayhan F, Tarabochia AD, Zu T, Perez BA, Tusi SK, Pletnikova O, Borchelt DR, Ross CA, Margolis RL, Yachnis AT, Troncoso JC, Ranum LP. RAN Translation in Huntington Disease. Neuron. 88: 667-77. PMID 26590344 DOI: 10.1016/J.Neuron.2015.10.038  0.361
2015 Pletnikova O, Rudow GL, Hyde TM, Kleinman JE, Ali SZ, Bharadwaj R, Gangadeen S, Crain BJ, Fowler DR, Rubio AI, Troncoso JC. Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age. Cognitive and Behavioral Neurology : Official Journal of the Society For Behavioral and Cognitive Neurology. 28: 144-52. PMID 26413742 DOI: 10.1097/Wnn.0000000000000071  0.333
2015 O'Hearn EE, Hwang HS, Holmes SE, Rudnicki DD, Chung DW, Seixas AI, Cohen RL, Ross CA, Trojanowski JQ, Pletnikova O, Troncoso JC, Margolis RL. Neuropathology and Cellular Pathogenesis of Spinocerebellar Ataxia Type 12. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 26340331 DOI: 10.1002/Mds.26348  0.301
2015 Chuang YF, An Y, Bilgel M, Wong DF, Troncoso JC, O'Brien RJ, Breitner JC, Ferruci L, Resnick SM, Thambisetty M. Midlife adiposity predicts earlier onset of Alzheimer's dementia, neuropathology and presymptomatic cerebral amyloid accumulation. Molecular Psychiatry. PMID 26324099 DOI: 10.1016/J.Jalz.2015.08.015  0.419
2015 Iacono D, Zandi P, Gross M, Markesbery WR, Pletnikova O, Rudow G, Troncoso JC. APOε2 and education in cognitively normal older subjects with high levels of AD pathology at autopsy: findings from the Nun Study. Oncotarget. 6: 14082-91. PMID 26101858 DOI: 10.18632/Oncotarget.4118  0.398
2015 Savonenko AV, Melnikova T, Wang Y, Ravert H, Gao Y, Koppel J, Lee D, Pletnikova O, Cho E, Sayyida N, Hiatt A, Troncoso J, Davies P, Dannals RF, Pomper MG, et al. Cannabinoid CB2 Receptors in a Mouse Model of Aβ Amyloidosis: Immunohistochemical Analysis and Suitability as a PET Biomarker of Neuroinflammation. Plos One. 10: e0129618. PMID 26086915 DOI: 10.1371/Journal.Pone.0129618  0.368
2015 Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, ... ... Troncoso JC, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2  0.416
2015 Beecham GW, Dickson DW, Scott WK, Martin ER, Schellenberg G, Nuytemans K, Larson EB, Buxbaum JD, Trojanowski JQ, Van Deerlin VM, Hurtig HI, Mash DC, Beach TG, Troncoso JC, Pletnikova O, et al. PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease. Neurology. 84: 972-80. PMID 25663231 DOI: 10.1212/Wnl.0000000000001332  0.311
2015 Hibar DP, Stein JL, Renteria ME, Arias-Vasquez A, Desrivières S, Jahanshad N, Toro R, Wittfeld K, Abramovic L, Andersson M, Aribisala BS, Armstrong NJ, Bernard M, Bohlken MM, Boks MP, ... ... Troncoso J, et al. Common genetic variants influence human subcortical brain structures. Nature. 520: 224-9. PMID 25607358 DOI: 10.1038/Nature14101  0.305
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Troncoso JC, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.39
2015 Dammer EB, Duong DM, Yin L, Swarup V, Parikshak N, Coppola G, Geschwind DH, Troncoso JC, Thambisetty M, Seyfried NT, Lah JJ, Levey AI. O4-12-02: Protein co-expression network analysis in Alzheimer's disease Alzheimer's & Dementia. 11: P299-P299. DOI: 10.1016/J.Jalz.2015.07.414  0.318
2015 Pletnikova O, Rudow GL, Hyde TM, Kleinman J, Ali SZ, Bharadwaj R, Crain BJ, Fowler D, Rubio AI, Troncoso JC. P1-207: Alzheimer's lesions in the brains of young subjects Alzheimer's & Dementia. 11: P429-P429. DOI: 10.1016/J.Jalz.2015.06.407  0.319
2014 Blue ME, Wilson MA, Beaty CA, George TJ, Arnaoutakis GJ, Haggerty KA, Jones M, Brawn J, Manmohan S, Lange MS, Johnston MV, Baumgartner WA, Troncoso JC. Brain injury in canine models of cardiac surgery. Journal of Neuropathology and Experimental Neurology. 73: 1134-43. PMID 25383634 DOI: 10.1097/Nen.0000000000000134  0.304
2014 Diner I, Hales CM, Bishof I, Rabenold L, Duong DM, Yi H, Laur O, Gearing M, Troncoso J, Thambisetty M, Lah JJ, Levey AI, Seyfried NT. Aggregation properties of the small nuclear ribonucleoprotein U1-70K in Alzheimer disease. The Journal of Biological Chemistry. 289: 35296-313. PMID 25355317 DOI: 10.1074/Jbc.M114.562959  0.309
2014 Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... ... Troncoso JC, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0  0.426
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Troncoso JC, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.333
2014 Gerson JE, Sengupta U, Lasagna-Reeves CA, Guerrero-Muñoz MJ, Troncoso J, Kayed R. Characterization of tau oligomeric seeds in progressive supranuclear palsy. Acta Neuropathologica Communications. 2: 73. PMID 24927818 DOI: 10.1186/2051-5960-2-73  0.352
2014 Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R. The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathologica Communications. 2: 56. PMID 24887264 DOI: 10.1186/2051-5960-2-56  0.405
2014 Liu G, Yu J, Ding J, Xie C, Sun L, Rudenko I, Zheng W, Sastry N, Luo J, Rudow G, Troncoso JC, Cai H. Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. The Journal of Clinical Investigation. 124: 3032-46. PMID 24865427 DOI: 10.1172/Jci72176  0.335
2014 Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, et al. HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Reports. 7: 1401-9. PMID 24857657 DOI: 10.1016/J.Celrep.2014.04.050  0.364
2014 Pletnikova O, Sloane KL, Renton AE, Traynor BJ, Crain BJ, Reid T, Zu T, Ranum LP, Troncoso JC, Rabins PV, Onyike CU. Hippocampal sclerosis dementia with the C9ORF72 hexanucleotide repeat expansion. Neurobiology of Aging. 35: 2419.e17-21. PMID 24819148 DOI: 10.1016/J.Neurobiolaging.2014.04.009  0.349
2014 Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ. U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21. Molecular Neurodegeneration. 9: 15. PMID 24773620 DOI: 10.1186/1750-1326-9-15  0.393
2014 Tsika E, Glauser L, Moser R, Fiser A, Daniel G, Sheerin UM, Lees A, Troncoso JC, Lewis PA, Bandopadhyay R, Schneider BL, Moore DJ. Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration. Human Molecular Genetics. 23: 4621-38. PMID 24740878 DOI: 10.1093/Hmg/Ddu178  0.334
2014 Iacono D, Resnick SM, O'Brien R, Zonderman AB, An Y, Pletnikova O, Rudow G, Crain B, Troncoso JC. Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. Journal of Neuropathology and Experimental Neurology. 73: 295-304. PMID 24607960 DOI: 10.1097/Nen.0000000000000052  0.393
2014 Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 507: 195-200. PMID 24598541 DOI: 10.1038/Nature13124  0.311
2014 Ho CY, Troncoso JC, Knox D, Stark W, Eberhart CG. Beta-amyloid, phospho-tau and alpha-synuclein deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients. Brain Pathology (Zurich, Switzerland). 24: 25-32. PMID 23714377 DOI: 10.1111/Bpa.12070  0.393
2013 Onyike CU, Pletnikova O, Sloane KL, Sullivan C, Troncoso JC, Rabins PV. Hippocampal sclerosis dementia: An amnesic variant of frontotemporal degeneration. Dementia & Neuropsychologia. 7: 83-87. PMID 24363834 DOI: 10.1590/S1980-57642013Dn70100013  0.315
2013 Herskowitz JH, Feng Y, Mattheyses AL, Hales CM, Higginbotham LA, Duong DM, Montine TJ, Troncoso JC, Thambisetty M, Seyfried NT, Levey AI, Lah JJ. Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19086-98. PMID 24305806 DOI: 10.1523/Jneurosci.2508-13.2013  0.412
2013 Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 110: E4968-77. PMID 24248382 DOI: 10.1073/Pnas.1315438110  0.351
2013 Hales CM, Rees H, Seyfried NT, Dammer EB, Duong DM, Gearing M, Montine TJ, Troncoso JC, Thambisetty M, Levey AI, Lah JJ, Wingo TS. Abnormal gephyrin immunoreactivity associated with Alzheimer disease pathologic changes. Journal of Neuropathology and Experimental Neurology. 72: 1009-15. PMID 24128675 DOI: 10.1097/01.Jnen.0000435847.59828.Db  0.424
2013 Thambisetty M, Jeffrey Metter E, Yang A, Dolan H, Marano C, Zonderman AB, Troncoso JC, Zhou Y, Wong DF, Ferrucci L, Egan J, Resnick SM, O'Brien RJ. Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging. Jama Neurology. 70: 1167-72. PMID 23897112 DOI: 10.1001/Jamaneurol.2013.284  0.33
2013 LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC. Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. Molecular Neurodegeneration. 8: 18. PMID 23764200 DOI: 10.1186/1750-1326-8-18  0.378
2013 Riudavets MA, Bartoloni L, Troncoso JC, Pletnikova O, St George-Hyslop P, Schultz M, Sevlever G, Allegri RF. Familial dementia with frontotemporal features associated with M146V presenilin-1 mutation. Brain Pathology (Zurich, Switzerland). 23: 595-600. PMID 23489366 DOI: 10.1111/Bpa.12051  0.365
2013 Jin J, Albertz J, Guo Z, Peng Q, Rudow G, Troncoso JC, Ross CA, Duan W. Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease. Journal of Neurochemistry. 125: 410-9. PMID 23373812 DOI: 10.1111/Jnc.12190  0.355
2013 Gerson J, Sengupta U, Lasagna Reeves C, Guerrero-Munoz M, Troncoso J, Jackson G, Kayed R. P4-334: Tau oligomers and annular protofibrils in progressive supranuclear palsy Alzheimer's & Dementia. 9: P854-P855. DOI: 10.1016/J.Jalz.2013.08.168  0.307
2012 Moghekar A, Kraut M, Elkins W, Troncoso J, Zonderman AB, Resnick SM, O'Brien RJ. Cerebral white matter disease is associated with Alzheimer pathology in a prospective cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: S71-7. PMID 23021624 DOI: 10.1016/J.Jalz.2012.04.006  0.386
2012 Guo Z, Rudow G, Pletnikova O, Codispoti KE, Orr BA, Crain BJ, Duan W, Margolis RL, Rosenblatt A, Ross CA, Troncoso JC. Striatal neuronal loss correlates with clinical motor impairment in Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 1379-86. PMID 22975850 DOI: 10.1002/Mds.25159  0.327
2012 Driscoll I, Troncoso JC, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut MA, Ferrucci L, Mathis CA, Klunk WE, O'Brien RJ, Davatzikos C, Wong DF, Resnick SM. Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathologica. 124: 823-31. PMID 22864813 DOI: 10.1007/S00401-012-1025-1  0.346
2012 Codispoti KE, Beason-Held LL, Kraut MA, O'Brien RJ, Rudow G, Pletnikova O, Crain B, Troncoso JC, Resnick SM. Longitudinal brain activity changes in asymptomatic Alzheimer disease. Brain and Behavior. 2: 221-30. PMID 22741095 DOI: 10.1002/Brb3.47  0.354
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Troncoso JC, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.397
2012 Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... ... Troncoso JC, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7  0.39
2012 Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK. Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3306-20. PMID 22399753 DOI: 10.1523/Jneurosci.5367-11.2012  0.324
2012 Colla E, Jensen PH, Pletnikova O, Troncoso JC, Glabe C, Lee MK. Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3301-5. PMID 22399752 DOI: 10.1523/Jneurosci.5368-11.2012  0.348
2012 Daher JP, Pletnikova O, Biskup S, Musso A, Gellhaar S, Galter D, Troncoso JC, Lee MK, Dawson TM, Dawson VL, Moore DJ. Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Human Molecular Genetics. 21: 2420-31. PMID 22357653 DOI: 10.1093/Hmg/Dds057  0.344
2012 Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR, Kayed R. Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 1946-59. PMID 22253473 DOI: 10.1096/Fj.11-199851  0.429
2012 Majounie E, Abramzon Y, Renton AE, Perry R, Bassett SS, Pletnikova O, Troncoso JC, Hardy J, Singleton AB, Traynor BJ. Repeat expansion in C9ORF72 in Alzheimer's disease. The New England Journal of Medicine. 366: 283-4. PMID 22216764 DOI: 10.1056/Nejmc1113592  0.396
2012 Ramonet D, Podhajska A, Stafa K, Sonnay S, Trancikova A, Tsika E, Pletnikova O, Troncoso JC, Glauser L, Moore DJ. PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity. Human Molecular Genetics. 21: 1725-43. PMID 22186024 DOI: 10.1093/Hmg/Ddr606  0.344
2012 Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC, Wong PC, Price DL. Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 261-77. PMID 21937983 DOI: 10.1038/Npp.2011.211  0.452
2012 Gleichmann M, Zhang Y, Wood WH, Becker KG, Mughal MR, Pazin MJ, van Praag H, Kobilo T, Zonderman AB, Troncoso JC, Markesbery WR, Mattson MP. Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks. Neurobiology of Aging. 33: 205.e1-18. PMID 20947216 DOI: 10.1016/J.Neurobiolaging.2010.08.012  0.382
2011 Airavaara M, Pletnikova O, Doyle ME, Zhang YE, Troncoso JC, Liu QR. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. The Journal of Biological Chemistry. 286: 45093-102. PMID 22081608 DOI: 10.1074/Jbc.M111.310250  0.38
2011 Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, et al. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent β-amyloid generation. Cell. 147: 615-28. PMID 22036569 DOI: 10.1016/J.Cell.2011.09.036  0.523
2011 Driscoll I, Troncoso J. Brain resilience and plasticity in the face of Alzheimer pathology. Current Alzheimer Research. 8: 329. PMID 21557722 DOI: 10.2174/156720511795745384  0.338
2011 Ramonet D, Daher JP, Lin BM, Stafa K, Kim J, Banerjee R, Westerlund M, Pletnikova O, Glauser L, Yang L, Liu Y, Swing DA, Beal MF, Troncoso JC, McCaffery JM, et al. Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. Plos One. 6: e18568. PMID 21494637 DOI: 10.1371/Journal.Pone.0018568  0.332
2011 Driscoll I, Troncoso J. Asymptomatic Alzheimer's disease: a prodrome or a state of resilience? Current Alzheimer Research. 8: 330-5. PMID 21222594 DOI: 10.2174/156720511795745348  0.392
2011 Liu Y, Lee MK, James MM, Price DL, Borchelt DR, Troncoso JC, Oh ES. Passive (amyloid-β) immunotherapy attenuates monoaminergic axonal degeneration in the AβPPswe/PS1dE9 mice. Journal of Alzheimer's Disease : Jad. 23: 271-9. PMID 20966549 DOI: 10.3233/Jad-2010-101602  0.457
2011 Kramer PL, Xu H, Woltjer RL, Westaway SK, Clark D, Erten-Lyons D, Kaye JA, Welsh-Bohmer KA, Troncoso JC, Markesbery WR, Petersen RC, Turner RS, Kukull WA, Bennett DA, Galasko D, et al. Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiology of Aging. 32: 2113-22. PMID 20452100 DOI: 10.1016/J.Neurobiolaging.2010.01.010  0.422
2011 Chow WHV, Lin S, Savonenko A, Hong W, Price D, Troncoso J, Wong P. Modeling a combination therapy for Alzheimer's disease: Inhibition of secretases and immunotherapy Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.09.017  0.488
2010 Dolan H, Crain B, Troncoso J, Resnick SM, Zonderman AB, Obrien RJ. Atherosclerosis, dementia, and Alzheimer disease in the Baltimore Longitudinal Study of Aging cohort. Annals of Neurology. 68: 231-40. PMID 20695015 DOI: 10.1002/Ana.22055  0.386
2010 Dolan D, Troncoso J, Resnick SM, Crain BJ, Zonderman AB, O'Brien RJ. Age, Alzheimer's disease and dementia in the Baltimore Longitudinal Study of Ageing. Brain : a Journal of Neurology. 133: 2225-31. PMID 20647264 DOI: 10.1093/Brain/Awq141  0.396
2010 Chiocco MJ, Zhu X, Walther D, Pletnikova O, Troncoso JC, Uhl GR, Liu QR. Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease. Substance Use & Misuse. 45: 1809-26. PMID 20590401 DOI: 10.3109/10826084.2010.482449  0.34
2010 Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human Molecular Genetics. 19: 2087-98. PMID 20185556 DOI: 10.1093/Hmg/Ddq086  0.313
2010 Dorfman VB, Pasquini L, Riudavets M, López-Costa JJ, Villegas A, Troncoso JC, Lopera F, Castaño EM, Morelli L. Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer's disease. Neurobiology of Aging. 31: 1743-57. PMID 19019493 DOI: 10.1016/J.Neurobiolaging.2008.09.016  0.38
2010 Price DL, Savonenko AV, Albert M, Troncoso JC, Wong PC. Aging of the Brain and Alzheimer's Disease Encyclopedia of Neuroscience. 187-195. DOI: 10.1016/B978-008045046-9.00539-8  0.463
2009 Lin X, Parisiadou L, Gu XL, Wang L, Shim H, Sun L, Xie C, Long CX, Yang WJ, Ding J, Chen ZZ, Gallant PE, Tao-Cheng JH, Rudow G, Troncoso JC, et al. Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron. 64: 807-27. PMID 20064389 DOI: 10.1016/J.Neuron.2009.11.006  0.31
2009 O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, Rudow G, Iacono D, Riudavets MA, Driscoll I, Price DL, Martin LJ, Troncoso JC. Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). Journal of Alzheimer's Disease : Jad. 18: 665-75. PMID 19661626 DOI: 10.3233/Jad-2009-1179  0.543
2009 Iacono D, Markesbery WR, Gross M, Pletnikova O, Rudow G, Zandi P, Troncoso JC. The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology. 73: 665-73. PMID 19587326 DOI: 10.1212/Wnl.0B013E3181B01077  0.389
2009 Earley CJ, Allen RP, Connor JR, Ferrucci L, Troncoso J. The dopaminergic neurons of the A11 system in RLS autopsy brains appear normal. Sleep Medicine. 10: 1155-7. PMID 19307154 DOI: 10.1016/J.Sleep.2009.01.006  0.305
2009 Tsang AH, Lee YI, Ko HS, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 106: 4900-5. PMID 19273858 DOI: 10.1073/Pnas.0810595106  0.307
2009 Oh ES, Savonenko AV, King JF, Fangmark Tucker SM, Rudow GL, Xu G, Borchelt DR, Troncoso JC. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiology of Aging. 30: 1238-44. PMID 18304698 DOI: 10.1016/J.Neurobiolaging.2007.12.024  0.378
2009 Bandaru VV, Troncoso J, Wheeler D, Pletnikova O, Wang J, Conant K, Haughey NJ. ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiology of Aging. 30: 591-9. PMID 17888544 DOI: 10.1016/J.Neurobiolaging.2007.07.024  0.396
2009 Tsang AHK, Lee YI, Han SK, Savitt JM, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM, Chung KKK. S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease (Proceedings of the National Academy of Sciences of the United States of America (2009) 106, 12, (4900-4905) DOI: 10.1073/pnas.0810595106) Proceedings of the National Academy of Sciences of the United States of America. 106: 8791. DOI: 10.1073/Pnas.0903257106  0.307
2009 Troncoso JC. Neuronal hypertrophy in asymptomatic Alzheimer's disease Alzheimers & Dementia. 5: 70. DOI: 10.1016/J.Jalz.2009.05.160  0.392
2009 Iacono D, Zandi P, Gross M, Markesbary WR, Pletnikova O, Rudow G, Troncoso JC. P4-131: The frequency of ApoE2 is increased in asymptomatic Alzheimer's: The Nun Study cohort Alzheimer's & Dementia. 5: P470-P470. DOI: 10.1016/J.Jalz.2009.04.799  0.31
2008 Oh ES, Troncoso JC, Fangmark Tucker SM. Maximizing the potential of plasma amyloid-beta as a diagnostic biomarker for Alzheimer's disease. Neuromolecular Medicine. 10: 195-207. PMID 18543125 DOI: 10.1007/S12017-008-8035-0  0.342
2008 Iacono D, O'Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, An Y, West MJ, Crain B, Troncoso JC. Neuronal hypertrophy in asymptomatic Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 67: 578-89. PMID 18520776 DOI: 10.1097/Nen.0B013E3181772794  0.423
2008 Troncoso JC, Zonderman AB, Resnick SM, Crain B, Pletnikova O, O'Brien RJ. Effect of infarcts on dementia in the Baltimore longitudinal study of aging. Annals of Neurology. 64: 168-76. PMID 18496870 DOI: 10.1002/Ana.21413  0.371
2008 Rudow G, O'Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso JC. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathologica. 115: 461-70. PMID 18297291 DOI: 10.1007/S00401-008-0352-8  0.325
2008 Tucker SM, Borchelt DR, Troncoso JC. Limited clearance of pre-existing amyloid plaques after intracerebral injection of Abeta antibodies in two mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 67: 30-40. PMID 18091561 DOI: 10.1097/Nen.0B013E31815F38D2  0.333
2008 Tan JM, Wong ES, Kirkpatrick DS, Pletnikova O, Ko HS, Tay SP, Ho MW, Troncoso J, Gygi SP, Lee MK, Dawson VL, Dawson TM, Lim KL. Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Human Molecular Genetics. 17: 431-9. PMID 17981811 DOI: 10.1093/Hmg/Ddm320  0.305
2008 Iacono D, Pletnikova O, Patel E, Tudor D, Markesbery WR, Zandi P, Troncoso JC, Snowdon D. P1-393: Hypertrophy of CA1-hippocampal neurons and APOE frequency in asymptomatic Alzheimer's disease: Findings from the Nun Study Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.974  0.307
2008 Troncoso JC, Riudavets MA, Schultz M, Sevlever G, Rudow G, Pletnikova O, Resnick S, Zonderman A, An Y, O'Brien R. P3-319: Elevated expression of cell cycle proteins in very early stages of Alzheimer's disease Alzheimer's & Dementia. 4: T615-T615. DOI: 10.1016/J.Jalz.2008.05.1888  0.336
2007 Morgan MD, Mielke MM, O'Brien R, Troncoso JC, Zonderman AB, Lyketsos CG. Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Alzheimer Disease and Associated Disorders. 21: 199-204. PMID 17804951 DOI: 10.1097/Wad.0B013E3181461932  0.358
2007 Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC. Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiology of Aging. 28: 1484-92. PMID 17599696 DOI: 10.1016/J.Neurobiolaging.2007.05.005  0.416
2007 Tucker SM, Oh E, Borchelt D, Troncoso J. Biotinylated anti-Aβ antibody as a tool to diagnose pre-clinical stages of Alzheimer disease (AD) Journal of Neuropathology and Experimental Neurology. 66: 419-420. DOI: 10.1097/01.Jnen.0000268981.06535.85  0.353
2007 Tucker SM, Oh E, Borchelt D, Troncoso J. Biotinylated anti-A{beta} antibody as a tool to diagnose pre-clinical stages of Alzheimer's Disease (AD) The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A20-A  0.336
2007 Iacono D, O'Brien R, Resnick S, Zonderman A, Pletnikova O, Rudow G, Crain B, Troncoso J. Differential nuclear and nucleolar hypertrophy of anterior and posterior cingulate neurons in asymptomatic subjects with AD pathology Journal of Neuropathology and Experimental Neurology. 66: 419. DOI: 10.1096/Fasebj.21.5.A19-C  0.345
2007 Oh E, Tucker S, Borchelt D, Troncoso J. P-053: Use of a biotinylated anti-Aβ antibody to diagnose preclinical Alzheimer's disease Alzheimer's & Dementia. 3: S114-S115. DOI: 10.1016/J.Jalz.2007.04.306  0.345
2006 Driscoll I, Resnick SM, Troncoso JC, An Y, O'Brien R, Zonderman AB. Impact of Alzheimer's pathology on cognitive trajectories in nondemented elderly. Annals of Neurology. 60: 688-95. PMID 17192929 DOI: 10.1002/Ana.21031  0.325
2006 Riudavets MA, Rubio A, Cox C, Rudow G, Fowler D, Troncoso JC. The prevalence of Alzheimer neuropathologic lesions is similar in blacks and whites. Journal of Neuropathology and Experimental Neurology. 65: 1143-8. PMID 17146288 DOI: 10.1097/01.Jnen.0000248548.20799.A3  0.315
2006 Zamora E, Handisurya A, Shafti-Keramat S, Borchelt D, Rudow G, Conant K, Cox C, Troncoso JC, Kirnbauer R. Papillomavirus-like particles are an effective platform for amyloid-beta immunization in rabbits and transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 2662-70. PMID 16888028 DOI: 10.4049/Jimmunol.177.4.2662  0.325
2006 Koliatsos VE, Kecojevic A, Troncoso JC, Gastard MC, Bennett DA, Schneider JA. Early involvement of small inhibitory cortical interneurons in Alzheimer's disease. Acta Neuropathologica. 112: 147-62. PMID 16758165 DOI: 10.1007/S00401-006-0068-6  0.395
2006 Bäckman CM, Shan L, Zhang YJ, Hoffer BJ, Leonard S, Troncoso JC, Vonsatel P, Tomac AC. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Molecular and Cellular Endocrinology. 252: 160-6. PMID 16644101 DOI: 10.1016/J.Mce.2006.03.013  0.334
2006 Venkata Ratnam Bandaru V, Troncoso JC, Wheeler D, Morris M, Haughey NJ. P3-210: ApoE4-associated accumulation of cholesterol and ceramide in the brains of Alzheimer's patients Alzheimer's & Dementia. 2: S437-S437. DOI: 10.1016/J.Jalz.2006.05.1479  0.342
2006 Liu QR, Zhu XG, Gong JP, Lu L, Shaham Y, Pletnikova O, Troncoso JC, Uhl GR. Differential regulation of sense and antisense human BDNF/BDNFOS genes and rodent BDNF gene: Possible roles in Alzheimer's disease and addictions International Journal of Developmental Neuroscience. 24: 559. DOI: 10.1016/J.Ijdevneu.2006.09.208  0.309
2005 Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL. Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Human Molecular Genetics. 14: 3885-97. PMID 16278233 DOI: 10.1093/Hmg/Ddi413  0.317
2005 Ko HS, von Coelln R, Sriram SR, Kim SW, Chung KK, Pletnikova O, Troncoso J, Johnson B, Saffary R, Goh EL, Song H, Park BJ, Kim MJ, Kim S, Dawson VL, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7968-78. PMID 16135753 DOI: 10.1523/Jneurosci.2172-05.2005  0.325
2005 Pletnikova O, West N, Lee MK, Rudow GL, Skolasky RL, Dawson TM, Marsh L, Troncoso JC. Abeta deposition is associated with enhanced cortical alpha-synuclein lesions in Lewy body diseases. Neurobiology of Aging. 26: 1183-92. PMID 15917102 DOI: 10.1016/J.Neurobiolaging.2004.10.006  0.361
2005 Riudavets MA, Aronica-Pollak P, Troncoso JC. Pseudolaminar necrosis in cyanide intoxication: a neuropathology case report. The American Journal of Forensic Medicine and Pathology. 26: 189-91. PMID 15894858 DOI: 10.1097/01.Paf.0000160680.08769.54  0.303
2005 Mikolaenko I, Pletnikova O, Kawas CH, O'Brien R, Resnick SM, Crain B, Troncoso JC. Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). Journal of Neuropathology and Experimental Neurology. 64: 156-62. PMID 15751230 DOI: 10.1093/Jnen/64.2.156  0.346
2005 Li W, West N, Colla E, Pletnikova O, Troncoso JC, Marsh L, Dawson TM, Jäkälä P, Hartmann T, Price DL, Lee MK. Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proceedings of the National Academy of Sciences of the United States of America. 102: 2162-7. PMID 15684072 DOI: 10.1073/Pnas.0406976102  0.429
2005 Martin LJ, Liu Z, Troncoso J, Price DL. Neuronal cell death in human neurodegenerative diseases and their animal/cell models Apoptosis in Health and Disease: Clinical and Therapeutic Aspects. 96-155. DOI: 10.1017/CBO9780511663543.005  0.406
2005 Savonenko AV, Laird FM, Troncoso JC, Wong PC, Price DL. Role of Alzheimer's disease models in designing and testing experimental therapeutics Drug Discovery Today: Disease Models. 2: 305-312. DOI: 10.1016/J.Ddmod.2005.11.006  0.524
2004 Li W, Lesuisse C, Xu Y, Troncoso JC, Price DL, Lee MK. Stabilization of alpha-synuclein protein with aging and familial parkinson's disease-linked A53T mutation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7400-9. PMID 15317865 DOI: 10.1523/Jneurosci.1370-04.2004  0.464
2004 West MJ, Kawas CH, Stewart WF, Rudow GL, Troncoso JC. Hippocampal neurons in pre-clinical Alzheimer's disease. Neurobiology of Aging. 25: 1205-12. PMID 15312966 DOI: 10.1016/J.Neurobiolaging.2003.12.005  0.395
2004 Hatanpaa KJ, Blass DM, Pletnikova O, Crain BJ, Bigio EH, Hedreen JC, White CL, Troncoso JC. Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia. Neurology. 63: 538-42. PMID 15304590 DOI: 10.1212/01.Wnl.0000129543.46734.C0  0.406
2004 Blass DM, Hatanpaa KJ, Brandt J, Rao V, Steinberg M, Troncoso JC, Rabins PV. Dementia in hippocampal sclerosis resembles frontotemporal dementia more than Alzheimer disease. Neurology. 63: 492-7. PMID 15304580 DOI: 10.1212/01.Wnl.0000133008.89613.82  0.372
2004 Mitchelmore C, Büchmann-Møller S, Rask L, West MJ, Troncoso JC, Jensen NA. NDRG2: a novel Alzheimer's disease associated protein. Neurobiology of Disease. 16: 48-58. PMID 15207261 DOI: 10.1016/J.Nbd.2004.01.003  0.446
2004 Chung KK, Thomas B, Li X, Pletnikova O, Troncoso JC, Marsh L, Dawson VL, Dawson TM. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science (New York, N.Y.). 304: 1328-31. PMID 15105460 DOI: 10.1126/Science.1093891  0.319
2004 Cutler RG, Kelly J, Storie K, Pedersen WA, Tammara A, Hatanpaa K, Troncoso JC, Mattson MP. Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 2070-5. PMID 14970312 DOI: 10.1073/Pnas.0305799101  0.398
2004 Fonseca MI, Kawas CH, Troncoso JC, Tenner AJ. Neuronal localization of C1q in preclinical Alzheimer's disease. Neurobiology of Disease. 15: 40-6. PMID 14751769 DOI: 10.1016/J.Nbd.2003.09.004  0.44
2003 Bouffard JP, Mena H, Ripple M, Troncoso J. Mesencephalic cryptococcal abscesses presenting with parkinsonism as an initial manifestation of AIDS. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1354-7. PMID 14639681 DOI: 10.1002/Mds.10546  0.301
2003 Rosenblatt A, Abbott MH, Gourley LM, Troncoso JC, Margolis RL, Brandt J, Ross CA. Predictors of neuropathological severity in 100 patients with Huntington's disease. Annals of Neurology. 54: 488-93. PMID 14520661 DOI: 10.1002/Ana.10691  0.332
2003 Gastard MC, Troncoso JC, Koliatsos VE. Caspase activation in the limbic cortex of subjects with early Alzheimer's disease. Annals of Neurology. 54: 393-8. PMID 12953274 DOI: 10.1002/Ana.10680  0.365
2003 Zemaitaitis MO, Kim SY, Halverson RA, Troncoso JC, Lee JM, Muma NA. Transglutaminase activity, protein, and mRNA expression are increased in progressive supranuclear palsy. Journal of Neuropathology and Experimental Neurology. 62: 173-84. PMID 12578227 DOI: 10.1093/Jnen/62.2.173  0.325
2003 Vehmas AK, Kawas CH, Stewart WF, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease. Neurobiology of Aging. 24: 321-31. PMID 12498966 DOI: 10.1016/S0197-4580(02)00090-8  0.417
2002 Dal Forno G, Carson KA, Brookmeyer R, Troncoso J, Kawas CH, Brandt J. APOE genotype and survival in men and women with Alzheimer's disease Neurology. 58: 1045-1050. PMID 11940690 DOI: 10.1212/Wnl.58.7.1045  0.313
2001 Shake JG, Peck EA, Marban E, Gott VL, Johnston MV, Troncoso JC, Redmond JM, Baumgartner WA. Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. The Annals of Thoracic Surgery. 72: 1849-54. PMID 11789759 DOI: 10.1016/S0003-4975(01)03192-7  0.302
2001 Vehmas AK, Borchelt DR, Price DL, McCarthy D, Wills-Karp M, Peper MJ, Rudow G, Luyinbazi J, Siew LT, Troncoso JC. beta-Amyloid peptide vaccination results in marked changes in serum and brain Abeta levels in APPswe/PS1DeltaE9 mice, as detected by SELDI-TOF-based ProteinChip technology. Dna and Cell Biology. 20: 713-21. PMID 11788049 DOI: 10.1089/10445490152717578  0.492
2001 Margolis RL, O'Hearn E, Rosenblatt A, Willour V, Holmes SE, Franz ML, Callahan C, Hwang HS, Troncoso JC, Ross CA. A disorder similar to Huntington's disease is associated with a novel CAG repeat expansion. Annals of Neurology. 50: 373-80. PMID 11761463 DOI: 10.1002/Ana.1312  0.343
2001 Nucifora FC, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson TM, Ross CA. Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science (New York, N.Y.). 291: 2423-8. PMID 11264541 DOI: 10.1126/Science.1056784  0.346
2001 Gyure KA, Durham R, Stewart WF, Smialek JE, Troncoso JC. Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Archives of Pathology & Laboratory Medicine. 125: 489-92. PMID 11260621 DOI: 10.1043/0003-9985(2001)125<0489:Iaapdo>2.0.Co;2  0.383
2001 Sandberg G, Stewart W, Smialek J, Troncoso JC. The prevalence of the neuropathological lesions of Alzheimer's disease is independent of race and gender. Neurobiology of Aging. 22: 169-75. PMID 11182466 DOI: 10.1016/S0197-4580(00)00236-0  0.34
2000 Zemaitaitis MO, Lee JM, Troncoso JC, Muma NA. Transglutaminase-induced cross-linking of tau proteins in progressive supranuclear palsy. Journal of Neuropathology and Experimental Neurology. 59: 983-9. PMID 11089576 DOI: 10.1093/Jnen/59.11.983  0.379
2000 Kang DE, Pietrzik CU, Baum L, Chevallier N, Merriam DE, Kounnas MZ, Wagner SL, Troncoso JC, Kawas CH, Katzman R, Koo EH. Modulation of amyloid beta-protein clearance and Alzheimer's disease susceptibility by the LDL receptor-related protein pathway. The Journal of Clinical Investigation. 106: 1159-66. PMID 11067868 DOI: 10.1172/Jci11013  0.365
2000 West MJ, Kawas CH, Martin LJ, Troncoso JC. The CA1 region of the human hippocampus is a hot spot in Alzheimer's disease. Annals of the New York Academy of Sciences. 908: 255-9. PMID 10911964 DOI: 10.1111/J.1749-6632.2000.Tb06652.X  0.384
2000 Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. The American Journal of Pathology. 157: 277-86. PMID 10880397 DOI: 10.1016/S0002-9440(10)64538-5  0.417
2000 West MJ, Kawas C, Martin LJ, Troncoso JC. Stereological approaches to Alzheimer's disease and age related neuronal loss Neurobiology of Aging. 21: 72. DOI: 10.1016/S0197-4580(00)82546-4  0.373
2000 Vehmas AK, Kawas CH, Troncoso JC. Immune reactive cells in senile plaques and cognitive decline in AD Neurobiology of Aging. 21: 122. DOI: 10.1016/S0197-4580(00)82351-9  0.314
2000 Wang R, Uljon SN, Troncoso JC, Duff K. Molecular anatomy of amyloid β-peptides in Alzheimer's disease patient's brain by mass spectrometry Neurobiology of Aging. 21: 155. DOI: 10.1016/S0197-4580(00)82033-3  0.34
1999 Chambers CB, Lee JM, Troncoso JC, Reich S, Muma NA. Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease. Annals of Neurology. 46: 325-32. PMID 10482263 DOI: 10.1002/1531-8249(199909)46:3<325::Aid-Ana8>3.0.Co;2-V  0.405
1999 Engelender S, Kaminsky Z, Guo X, Sharp AH, Amaravi RK, Kleiderlein JJ, Margolis RL, Troncoso JC, Lanahan AA, Worley PF, Dawson VL, Dawson TM, Ross CA. Synphilin-1 associates with alpha-synuclein and promotes the formation of cytosolic inclusions. Nature Genetics. 22: 110-4. PMID 10319874 DOI: 10.1038/8820  0.303
1998 Troncoso JC, Cataldo AM, Nixon RA, Barnett JL, Lee MK, Checler F, Fowler DR, Smialek JE, Crain B, Martin LJ, Kawas CH. Neuropathology of preclinical and clinical late-onset Alzheimer's disease. Annals of Neurology. 43: 673-6. PMID 9585365 DOI: 10.1002/Ana.410430519  0.421
1997 Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 56: 933-44. PMID 9258263 DOI: 10.1097/00005072-199708000-00011  0.514
1997 LaFerla FM, Troncoso JC, Strickland DK, Kawas CH, Jay G. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Abeta stabilization. The Journal of Clinical Investigation. 100: 310-20. PMID 9218507 DOI: 10.1172/Jci119536  0.391
1997 McIntosh LJ, Trush MA, Troncoso JC. Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes. Free Radical Biology & Medicine. 23: 183-90. PMID 9199880 DOI: 10.1016/S0891-5849(96)00573-4  0.363
1996 Rasmusson DX, Brandt J, Steele C, Hedreen JC, Troncoso JC, Folstein MF. Accuracy of clinical diagnosis of Alzheimer disease and clinical features of patients with non-Alzheimer disease neuropathology. Alzheimer Disease and Associated Disorders. 10: 180-8. PMID 8939276 DOI: 10.1097/00002093-199601040-00002  0.418
1996 Troncoso JC, Sukhov RR, Kawas CH, Koliatsos VE. In situ labeling of dying cortical neurons in normal aging and in Alzheimer's disease: correlations with senile plaques and disease progression. Journal of Neuropathology and Experimental Neurology. 55: 1134-42. PMID 8939196 DOI: 10.1097/00005072-199611000-00004  0.418
1996 Troncoso JC, Kawas CH, Chang CK, Folstein MF, Hedreen JC. Lack of association of the apoE4 allele with hippocampal sclerosis dementia. Neuroscience Letters. 204: 138-40. PMID 8929997 DOI: 10.1016/0304-3940(96)12331-4  0.407
1996 Xiao J, Perry G, Troncoso J, Monteiro MJ. alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease. Journal of Neuropathology and Experimental Neurology. 55: 954-63. PMID 8800091 DOI: 10.1097/00005072-199609000-00002  0.325
1996 Troncoso JC, Martin LJ, Dal Forno G, Kawas CH. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging. Neurobiology of Aging. 17: 365-71. PMID 8725897 DOI: 10.1016/0197-4580(96)00028-0  0.346
1996 Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GV. Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Experimental Neurology. 138: 252-60. PMID 8620924 DOI: 10.1006/Exnr.1996.0064  0.361
1995 Furuta A, Price DL, Pardo CA, Troncoso JC, Xu ZS, Taniguchi N, Martin LJ. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. The American Journal of Pathology. 146: 357-67. PMID 7856748  0.448
1995 Raskin LS, Applegate MD, Price DL, Troncoso JC, Hedreen JC. Comparison of new and traditional methods for detection of senile plaques in Alzheimer's disease. Journal of Geriatric Psychiatry and Neurology. 8: 125-31. PMID 7794478 DOI: 10.1177/089198879500800211  0.524
1995 West MJ, Coleman PD, Flood DG, Troncoso JC. [Differential neuronal loss in the hippocampus in normal aging and in patients with Alzheimer disease]. Ugeskrift For Laeger. 157: 3190-3. PMID 7770982  0.312
1995 Behan DP, Heinrichs SC, Troncoso JC, Liu XJ, Kawas CH, Ling N, De Souza EB. Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease. Nature. 378: 284-7. PMID 7477348 DOI: 10.1038/378284A0  0.334
1994 West MJ, Coleman PD, Flood DG, Troncoso JC. Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease. Lancet (London, England). 344: 769-72. PMID 7916070 DOI: 10.1016/S0140-6736(94)92338-8  0.399
1993 Troncoso JC, Costello A, Watson AL, Johnson GV. In vitro polymerization of oxidized tau into filaments. Brain Research. 613: 313-6. PMID 8186983 DOI: 10.1016/0006-8993(93)90918-D  0.375
1992 Gilbert MR, Harding BL, Hoffman PN, Griffin JW, Price DL, Troncoso JC. Aluminum-induced neurofilamentous changes in cultured rat dorsal root ganglia explants. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 1763-71. PMID 1578268 DOI: 10.1523/Jneurosci.12-05-01763.1992  0.441
1990 Naidu S, Hyman S, Piazza K, Savedra J, Perman J, Wenk G, Kitt C, Troncoso J, Price D, Cassanova M, Miller D, Thomas G, Niedermeyer E, Moser H. The Rett syndrome: Progress report on studies at the Kennedy Institute Brain & Development. 12: 5-7. PMID 2344026 DOI: 10.1016/S0387-7604(12)80164-1  0.428
1990 Pardo CA, Martin LJ, Troncoso JC, Price DL. The human pineal gland in aging and Alzheimer's disease: patterns of cytoskeletal antigen immunoreactivity. Acta Neuropathologica. 80: 535-40. PMID 2251911 DOI: 10.1007/Bf00294615  0.54
1990 Price DL, Sisodia SS, Koo EH, Muma NA, Kitt CA, Walker LC, Martin LJ, Troncoso JC, Griffin JW, Hoffman PN. Neuronal disorders: studies of animal models and human diseases. Toxicologic Pathology. 18: 128-37. PMID 2195633 DOI: 10.1177/019262339001800118  0.499
1990 Hedreen JC, Raskin LS, Applegate MD, Price DL, Troncoso JC. A QUICK SILVER METHOD FOR SENILE PLAQUES AND A COMPARISON OF EIGHT METHODS FOR THE DEMONSTRATION OF SENILE PLAQUES Journal of Neuropathology and Experimental Neurology. 49: 308. DOI: 10.1097/00005072-199005000-00148  0.434
1990 Troncoso JC, Pardo CA, Martin LJ, Price DL. THE PINEAL GLAND IN AGING AND ALZHEIMERʼS DISEASE Journal of Neuropathology and Experimental Neurology. 49: 307. DOI: 10.1097/00005072-199005000-00145  0.456
1988 Muma NA, Troncoso JC, Hoffman PN, Koo EH, Price DL. Aluminum neurotoxicity: altered expression of cytoskeletal genes. Brain Research. 427: 115-21. PMID 3382937 DOI: 10.1016/0169-328X(88)90056-3  0.462
1988 Naidu S, Kitt CA, Wong DF, Price DL, Troncoso JC, Moser HW. Research on Rett syndrome: strategy and preliminary results. Journal of Child Neurology. 3: S78-86. PMID 3058792 DOI: 10.1177/0883073888003001S16  0.457
1988 Cork LC, Troncoso JC, Klavano GG, Johnson ES, Sternberger LA, Sternberger NH, Price DL. Neurofilamentous abnormalities in motor neurons in spontaneously occurring animal disorders. Journal of Neuropathology and Experimental Neurology. 47: 420-31. PMID 2455022 DOI: 10.1097/00005072-198807000-00003  0.503
1988 Muma NA, Troncoso JC, Hoffman PN, Koo EH, Price DL. Aluminum neurotoxicity: altered expression of cytoskeletal genes Molecular Brain Research. 3: 115-121. DOI: 10.1016/0169-328X(88)90056-3  0.387
1987 Casanova MF, Troncoso JC, Price DL. Cerebral hemorrhagic infarcts: an autopsy study of 76 cases. Boletã­N De La Asociaciã³N Mã©Dica De Puerto Rico. 79: 7-11. PMID 3442583  0.319
1987 Troncoso JC, Price DL, Aebi U. NORMAL AND ABNORMAL ASSEMBLY OF NEUROFILAMENTS IN VITRO Journal of Neuropathology and Experimental Neurology. 46: 350. DOI: 10.1097/00005072-198705000-00062  0.419
1987 Hedreen JC, Price DL, Troncoso JC. DISTRIBUTION OF SENILE PLAGUES IN ALZHEIMERʼS DISEASE, AS SEEN WITH A NEW SILVER METHOD Journal of Neuropathology and Experimental Neurology. 46: 335. DOI: 10.1097/00005072-198705000-00017  0.446
1986 Troncoso JC, Sternberger NH, Sternberger LA, Hoffman PN, Price DL. Immunocytochemical studies of neurofilament antigens in the neurofibrillary pathology induced by aluminum. Brain Research. 364: 295-300. PMID 3512034 DOI: 10.1016/0006-8993(86)90842-5  0.487
1986 Casanova MF, Troncoso JC, Price DL. Hematogenous origin of brain macrophages: a case report. Neurology. 36: 844-7. PMID 3458032 DOI: 10.1212/Wnl.36.6.844  0.445
1985 Troncoso JC, Hoffman PN, Griffin JW, Hess-Kozlow KM, Price DL. Aluminum intoxication: a disorder of neurofilament transport in motor neurons. Brain Research. 342: 172-5. PMID 4041808 DOI: 10.1016/0006-8993(85)91369-1  0.457
1985 Troncoso JC, Cork LC, Price DL. Canine inherited ataxia: ultrastructural observations. Journal of Neuropathology and Experimental Neurology. 44: 165-75. PMID 3973637 DOI: 10.1097/00005072-198503000-00005  0.488
1984 Tiemeyer MJ, Singer HS, Troncoso JC, Cork LC, Coyle JT, Price DL. Synaptic neurochemical alterations associated with neuronal degeneration in an inherited cerebellar ataxia of Gordon Setters. Journal of Neuropathology and Experimental Neurology. 43: 580-91. PMID 6502189 DOI: 10.1097/00005072-198411000-00003  0.474
1983 Cork LC, Troncoso JC, Price DL, Stanley EF, Griffin JW. Canine neuroaxonal dystrophy. Journal of Neuropathology and Experimental Neurology. 42: 286-96. PMID 6842267 DOI: 10.1097/00005072-198305000-00006  0.428
1983 Troncoso JC, Whitehouse PJ, Kuhar MJ, Griffin JW, Cork LC, Price DL. 24 CHANGES OF MOTOR NEURON CHOLINERGIC RECEPTORS AFTER AXOTOMY Journal of Neuropathology and Experimental Neurology. 42: 313. DOI: 10.1097/00005072-198305000-00034  0.43
1982 Troncoso JC, Price DL, Griffin JW, Parhad IM. Neurofibrillary axonal pathology in aluminum intoxication. Annals of Neurology. 12: 278-83. PMID 7137964 DOI: 10.1002/Ana.410120312  0.461
1982 Troncoso JC, Griffin JW, Price DL, Hess-Kozlow KM. Pathology of the peripheral neuropathy induced by p-bromophenylacetylurea. Laboratory Investigation; a Journal of Technical Methods and Pathology. 46: 215-23. PMID 7062723  0.339
1982 Griffin J, Cork LC, Troncoso JC, Price DL. Experimental neurotoxic disorders of motor neurons: neurofibrillary pathology. Advances in Neurology. 36: 419-33. PMID 6891174  0.38
1981 Steinberg HS, Troncoso JC, Cork LC, Price DL. Clinical features of inherited cerebellar degeneration in Gordon setters. Journal of the American Veterinary Medical Association. 179: 886-90. PMID 7341602  0.42
1981 Cork LC, Troncoso JC, Price DL. Canine inherited ataxia. Annals of Neurology. 9: 492-8. PMID 7271243 DOI: 10.1002/Ana.410090512  0.474
1981 Troncoso JC, Johnston MV, Hess KM, Griffin JW, Price DL. Model of Wernicke's encephalopathy. Archives of Neurology. 38: 350-4. PMID 7236062 DOI: 10.1001/Archneur.1981.00510060052007  0.469
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