| Year |
Citation |
Score |
| 2023 |
Chapdelaine AG, Ku GC, Sun G, Ayrapetov MK. The Targeted Degradation of BRAF V600E Reveals the Mechanisms of Resistance to BRAF-Targeted Treatments in Colorectal Cancer Cells. Cancers. 15. PMID 38136350 DOI: 10.3390/cancers15245805 |
0.693 |
|
| 2023 |
Sun G, Ayrapetov MK. Dissection of the catalytic and regulatory structure-function relationships of Csk protein tyrosine kinase. Frontiers in Cell and Developmental Biology. 11: 1148352. PMID 36936693 DOI: 10.3389/fcell.2023.1148352 |
0.805 |
|
| 2022 |
Ku GC, Chapdelaine AG, Ayrapetov MK, Sun G. Identification of Lethal Inhibitors and Inhibitor Combinations for Mono-Driver versus Multi-Driver Triple-Negative Breast Cancer Cells. Cancers. 14. PMID 36011019 DOI: 10.3390/cancers14164027 |
0.731 |
|
| 2020 |
Chen L, Marsiglia WM, Chen H, Katigbak J, Erdjument-Bromage H, Kemble DJ, Fu L, Ma J, Sun G, Zhang Y, Liang G, Neubert TA, Li X, Traaseth NJ, Mohammadi M. Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation. Nature Chemical Biology. PMID 31959966 DOI: 10.1038/S41589-019-0455-7 |
0.81 |
|
| 2019 |
Liu C, Mu X, Wang X, Zhang C, Zhang L, Yu B, Sun G. Ponatinib Inhibits Proliferation and Induces Apoptosis of Liver Cancer Cells, but Its Efficacy Is Compromised by Its Activation on PDK1/Akt/mTOR Signaling. Molecules (Basel, Switzerland). 24. PMID 30959969 DOI: 10.3390/molecules24071363 |
0.334 |
|
| 2019 |
Li L, Cui Y, Shen J, Dobson H, Sun G. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1. Leukemia Research. 78: 12-20. PMID 30660961 DOI: 10.1016/j.leukres.2019.01.006 |
0.397 |
|
| 2018 |
Cui Y, Sun G. Structural versatility that serves the function of the HRD motif in the catalytic loop of protein tyrosine kinase, Src. Protein Science : a Publication of the Protein Society. PMID 30461096 DOI: 10.1002/pro.3554 |
0.396 |
|
| 2016 |
Tiwari RK, Brown A, Shirazi AN, Bolton J, Tse A, Verkhivker G, Parang K, Sun G. Design, Synthesis, and Evaluation of Dasatinib-Amino Acid and Dasatinib-Fatty Acid Conjugates as Protein Tyrosine Kinase Inhibitors. Chemmedchem. PMID 27875633 DOI: 10.1002/Cmdc.201600387 |
0.359 |
|
| 2016 |
Li J, Qin S, Xu J, Xiong J, Wu C, Bai Y, Liu W, Tong J, Liu Y, Xu R, Wang Z, Wang Q, Ouyang X, Yang Y, Ba Y, ... ... Sun G, et al. Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 1448-54. PMID 26884585 DOI: 10.1200/JCO.2015.63.5995 |
0.358 |
|
| 2013 |
Sun G, Lin X, Shen L, Wu F, Xu D, Ruan K, Feng Y. Mono-PEGylated radix ophiopogonis polysaccharide for the treatment of myocardial ischemia. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 49: 629-36. PMID 23727058 DOI: 10.1016/j.ejps.2013.05.020 |
0.328 |
|
| 2013 |
Nasrolahi Shirazi A, Tiwari RK, Brown A, Mandal D, Sun G, Parang K. Cyclic peptides containing tryptophan and arginine as Src kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 3230-4. PMID 23602444 DOI: 10.1016/J.Bmcl.2013.03.124 |
0.458 |
|
| 2011 |
Sun G, Lin X, Wang Z, Feng Y, Xu D, Shen L. PEGylated inulin as long-circulating pharmaceutical carrier. Journal of Biomaterials Science. Polymer Edition. 22: 429-41. PMID 20566038 DOI: 10.1163/092050610X487729 |
0.35 |
|
| 2010 |
Sun GL, Lin X. [Mechanisms and strategies for targeting drugs to myocardial ischemic regions]. Yao Xue Xue Bao = Acta Pharmaceutica Sinica. 45: 827-32. PMID 20931778 |
0.325 |
|
| 2010 |
Lin X, Wang S, Jiang Y, Wang ZJ, Sun GL, Xu DS, Feng Y, Shen L. Poly(ethylene glycol)-radix Ophiopogonis polysaccharide conjugates: preparation, characterization, pharmacokinetics and in vitro bioactivity. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 76: 230-7. PMID 20633648 DOI: 10.1016/j.ejpb.2010.07.003 |
0.35 |
|
| 2010 |
Tiwari R, Brown A, Narramaneni S, Sun G, Parang K. Synthesis and evaluation of conformationally constrained peptide analogues as the Src SH3 domain binding ligands. Biochimie. 92: 1153-63. PMID 20109515 DOI: 10.1016/J.Biochi.2010.01.017 |
0.467 |
|
| 2010 |
Lin X, Wang Z, Sun G, Shen L, Xu D, Feng Y. A sensitive and specific HPGPC-FD method for the study of pharmacokinetics and tissue distribution of Radix Ophiopogonis polysaccharide in rats. Biomedical Chromatography : Bmc. 24: 820-5. PMID 20020416 DOI: 10.1002/bmc.1369 |
0.31 |
|
| 2009 |
Sun G, Kemble DJ. To C or not to C: direct and indirect redox regulation of Src protein tyrosine kinase. Cell Cycle (Georgetown, Tex.). 8: 2353-5. PMID 19571676 DOI: 10.4161/Cc.8.15.9225 |
0.802 |
|
| 2009 |
Ye G, Schuler AD, Ahmadibeni Y, Morgan JR, Faruqui A, Huang K, Sun G, Zebala JA, Parang K. Synthesis and evaluation of phosphopeptides containing iminodiacetate groups as binding ligands of the Src SH2 domain. Bioorganic Chemistry. 37: 133-42. PMID 19539345 DOI: 10.1016/J.Bioorg.2009.05.003 |
0.61 |
|
| 2009 |
Kemble DJ, Sun G. Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation. Proceedings of the National Academy of Sciences of the United States of America. 106: 5070-5. PMID 19273857 DOI: 10.1073/Pnas.0806117106 |
0.809 |
|
| 2009 |
Huang K, Wang YH, Brown A, Sun G. Identification of N-terminal lobe motifs that determine the kinase activity of the catalytic domains and regulatory strategies of Src and Csk protein tyrosine kinases. Journal of Molecular Biology. 386: 1066-77. PMID 19244618 DOI: 10.1016/J.Jmb.2009.01.012 |
0.694 |
|
| 2007 |
Wang YH, Huang K, Lin X, Sun G. Subdomain switching reveals regions that harbor substrate specificity and regulatory properties of protein tyrosine kinases. Biochemistry. 46: 10162-9. PMID 17691821 DOI: 10.1021/Bi7007257 |
0.77 |
|
| 2007 |
Ahmadibeni Y, Hanley M, White M, Ayrapetov M, Lin X, Sun G, Parang K. Metal-binding properties of a dicysteine-containing motif in protein tyrosine kinases. Chembiochem : a European Journal of Chemical Biology. 8: 1592-605. PMID 17674392 DOI: 10.1002/Cbic.200700242 |
0.788 |
|
| 2007 |
Ye G, Nam NH, Kumar A, Saleh A, Shenoy DB, Amiji MM, Lin X, Sun G, Parang K. Synthesis and evaluation of tripodal peptide analogues for cellular delivery of phosphopeptides. Journal of Medicinal Chemistry. 50: 3604-17. PMID 17580848 DOI: 10.1021/Jm070416O |
0.442 |
|
| 2007 |
Kumar A, Wang Y, Lin X, Sun G, Parang K. Synthesis and evaluation of 3-phenylpyrazolo[3,4-d]pyrimidine-peptide conjugates as Src kinase inhibitors. Chemmedchem. 2: 1346-60. PMID 17530729 DOI: 10.1002/Cmdc.200700074 |
0.535 |
|
| 2006 |
Gu X, Wang Y, Kumar A, Ye G, Parang K, Sun G. Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase. Journal of Medicinal Chemistry. 49: 7532-9. PMID 17149882 DOI: 10.1021/Jm061058C |
0.498 |
|
| 2006 |
Kemble DJ, Wang YH, Sun G. Bacterial expression and characterization of catalytic loop mutants of SRC protein tyrosine kinase. Biochemistry. 45: 14749-54. PMID 17144667 DOI: 10.1021/Bi061664+ |
0.817 |
|
| 2006 |
Sun G, Sun L, Wen H, Jia Z, Huang K, Hu C. From layered double hydroxide to spinel nanostructures: facile synthesis and characterization of nanoplatelets and nanorods. The Journal of Physical Chemistry. B. 110: 13375-80. PMID 16821857 DOI: 10.1021/jp060916d |
0.45 |
|
| 2006 |
Ayrapetov MK, Wang YH, Lin X, Gu X, Parang K, Sun G. Conformational basis for SH2-Tyr(P)527 binding in Src inactivation. The Journal of Biological Chemistry. 281: 23776-84. PMID 16790421 DOI: 10.1074/Jbc.M604219200 |
0.79 |
|
| 2006 |
Wang YH, Ayrapetov MK, Lin X, Sun G. A new strategy to produce active human Src from bacteria for biochemical study of its regulation. Biochemical and Biophysical Research Communications. 346: 606-11. PMID 16765913 DOI: 10.1016/J.Bbrc.2006.05.180 |
0.822 |
|
| 2006 |
Kumar A, Ye G, Wang Y, Lin X, Sun G, Parang K. Synthesis and structure-activity relationships of linear and conformationally constrained peptide analogues of CIYKYY as Src tyrosine kinase inhibitors. Journal of Medicinal Chemistry. 49: 3395-401. PMID 16722659 DOI: 10.1021/Jm060334K |
0.522 |
|
| 2006 |
Lin X, Wang Y, Ahmadibeni Y, Parang K, Sun G. Structural basis for domain-domain communication in a protein tyrosine kinase, the C-terminal Src kinase. Journal of Molecular Biology. 357: 1263-73. PMID 16483606 DOI: 10.1016/J.Jmb.2006.01.046 |
0.637 |
|
| 2006 |
Lee S, Ayrapetov MK, Kemble DJ, Parang K, Sun G. Docking-based substrate recognition by the catalytic domain of a protein tyrosine kinase, C-terminal Src kinase (Csk). The Journal of Biological Chemistry. 281: 8183-9. PMID 16439366 DOI: 10.1074/Jbc.M508120200 |
0.802 |
|
| 2005 |
Lin X, Ayrapetov MK, Sun G. Characterization of the interactions between the active site of a protein tyrosine kinase and a divalent metal activator. Bmc Biochemistry. 6: 25. PMID 16305747 DOI: 10.1186/1471-2091-6-25 |
0.818 |
|
| 2005 |
Ye G, Ayrapetov M, Nam NH, Sun G, Parang K. Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain. Bioorganic & Medicinal Chemistry Letters. 15: 4994-7. PMID 16169725 DOI: 10.1016/J.Bmcl.2005.08.005 |
0.775 |
|
| 2005 |
Ayrapetov MK, Nam NH, Ye G, Kumar A, Parang K, Sun G. Functional diversity of Csk, Chk, and Src SH2 domains due to a single residue variation. The Journal of Biological Chemistry. 280: 25780-7. PMID 15890649 DOI: 10.1074/Jbc.M504022200 |
0.799 |
|
| 2005 |
Sun G, Cao M, Wang Y, Hu C, Ren L, Huang K. Controlled synthesis of nanorods/nanorings of a novel Co-Cu complex in microemulsion at room temperature. Chemical Communications (Cambridge, England). 1740-2. PMID 15791317 DOI: 10.1039/b416222f |
0.444 |
|
| 2005 |
Lin X, Ayrapetov MK, Lee S, Parang K, Sun G. Probing the communication between the regulatory and catalytic domains of a protein tyrosine kinase, Csk. Biochemistry. 44: 1561-7. PMID 15683240 DOI: 10.1021/Bi048142J |
0.797 |
|
| 2005 |
Lieser SA, Shindler C, Aubol BE, Lee S, Sun G, Adams JA. Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition. The Journal of Biological Chemistry. 280: 7769-76. PMID 15623523 DOI: 10.1074/Jbc.M411736200 |
0.534 |
|
| 2005 |
Parang K, Sun G. Recent advances in the discovery of Src kinase inhibitors Expert Opinion On Therapeutic Patents. 15: 1183-1207. DOI: 10.1517/13543776.15.9.1183 |
0.517 |
|
| 2004 |
Parang K, Sun G. Design strategies for protein kinase inhibitors. Current Opinion in Drug Discovery & Development. 7: 617-29. PMID 15503864 |
0.443 |
|
| 2004 |
Nam NH, Lee S, Ye G, Sun G, Parang K. ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases. Bioorganic & Medicinal Chemistry. 12: 5753-66. PMID 15498652 DOI: 10.1016/J.Bmc.2004.08.043 |
0.53 |
|
| 2004 |
Nam NH, Ye G, Sun G, Parang K. Conformationally constrained peptide analogues of pTyr-Glu-Glu-Ile as inhibitors of the Src SH2 domain binding. Journal of Medicinal Chemistry. 47: 3131-41. PMID 15163193 DOI: 10.1021/Jm040008+ |
0.376 |
|
| 2004 |
Nam NH, Pitts RL, Sun G, Sardari S, Tiemo A, Xie M, Yan B, Parang K. Design of tetrapeptide ligands as inhibitors of the Src SH2 domain. Bioorganic & Medicinal Chemistry. 12: 779-87. PMID 14759738 DOI: 10.1016/J.Bmc.2003.10.060 |
0.425 |
|
| 2003 |
Lee S, Lin X, Nam NH, Parang K, Sun G. Determination of the substrate-docking site of protein tyrosine kinase C-terminal Src kinase. Proceedings of the National Academy of Sciences of the United States of America. 100: 14707-12. PMID 14657361 DOI: 10.1073/Pnas.2534493100 |
0.648 |
|
| 2003 |
Ayrapetov MK, Lee S, Sun G. Expression, purification, and biochemical characterization of Chk, a soluble protein tyrosine kinase. Protein Expression and Purification. 29: 148-55. PMID 12767803 DOI: 10.1016/S1046-5928(02)00698-8 |
0.809 |
|
| 2003 |
Lin X, Lee S, Sun G. Functions of the activation loop in Csk protein-tyrosine kinase. The Journal of Biological Chemistry. 278: 24072-7. PMID 12686554 DOI: 10.1074/Jbc.M210596200 |
0.612 |
|
| 2002 |
Lee S, Lin X, McMurray J, Sun G. Contribution of an active site cation-pi interaction to the spectroscopic properties and catalytic function of protein tyrosine kinase Csk. Biochemistry. 41: 12107-14. PMID 12356311 DOI: 10.1021/Bi026439G |
0.626 |
|
| 2002 |
Sun G, Ramdas L, Wang W, Vinci J, McMurray J, Budde RJ. Effect of autophosphorylation on the catalytic and regulatory properties of protein tyrosine kinase Src. Archives of Biochemistry and Biophysics. 397: 11-7. PMID 11747305 DOI: 10.1006/Abbi.2001.2627 |
0.527 |
|
| 2001 |
Zeng Y, Huang K, Xu C, Zhang J, Sun G. Biorheological characteristics of skin after expansion. Biorheology. 38: 367-78. PMID 12016320 |
0.455 |
|
| 2001 |
Shaffer J, Sun G, Adams JA. Nucleotide release and associated conformational changes regulate function in the COOH-terminal Src kinase, Csk. Biochemistry. 40: 11149-55. PMID 11551213 DOI: 10.1021/Bi011029Y |
0.478 |
|
| 2001 |
Sun G, Budde RJA. Affinity purification of Csk protein tyrosine kinase based on its catalytic requirement for divalent metal cations. Protein Expression and Purification. 21: 8-12. PMID 11162381 DOI: 10.1006/Prep.2000.1351 |
0.441 |
|
| 2001 |
Budde RJA, Ramdas L, Sun G. Cloning, expression, purification and characterization of the alternate splice Src variants for drug discovery Journal of Molecular Catalysis B-Enzymatic. 11: 805-809. DOI: 10.1016/S1381-1177(00)00058-8 |
0.428 |
|
| 2000 |
Wang W, Ramdas L, Sun G, Ke S, Obeyesekere NU, Budde RJA, McMurray JS. Cyclic peptides incorporating 4-carboxyphenylalanine and phosphotyrosine are potent inhibitors of pp60(c-src) Biochemistry. 39: 5221-5228. PMID 10819990 DOI: 10.1021/Bi992994F |
0.5 |
|
| 1999 |
Ramdas L, Bunnin BA, Plunkett MJ, Sun G, Ellman J, Gallick GE, Budde RJA. Benzodiazepine Compounds As Inhibitors Of The Src Protein Tyrosine Kinase : Screening Of A Combinatorial Library Of 1,4-Benzodiazepines Archives of Biochemistry and Biophysics. 368: 394-400. PMID 10441393 DOI: 10.1006/Abbi.1999.1313 |
0.457 |
|
| 1999 |
Ramdas L, Obeyesekere NU, Sun G, McMurray JS, Budde RJA. N-myristoylation of a peptide substrate for Src converts it into an apparent slow-binding bisubstrate-type inhibitor Journal of Peptide Research. 53: 569-577. PMID 10424353 DOI: 10.1034/J.1399-3011.1999.00063.X |
0.399 |
|
| 1999 |
Sun G, Budde RJA. Mutations in the N-terminal regulatory region reduce the catalytic activity of Csk, but do not affect its recognition of Src. Archives of Biochemistry and Biophysics. 367: 167-172. PMID 10395732 DOI: 10.1006/Abbi.1999.1253 |
0.561 |
|
| 1999 |
Sun G, Budde RJA. Substitution Studies of the Second Divalent Metal Cation Requirement of Protein Tyrosine Kinase CSK Biochemistry. 38: 5659-5665. PMID 10220355 DOI: 10.1021/Bi982793W |
0.362 |
|
| 1998 |
Sun G, Sharma AK, Budde RJ. Autophosphorylation of Src and Yes blocks their inactivation by Csk phosphorylation. Oncogene. 17: 1587-1595. PMID 9794236 DOI: 10.1038/Sj.Onc.1202076 |
0.574 |
|
| 1997 |
Sun G, Budde RJA. Expression, Purification, and Initial Characterization of Human Yes Protein Tyrosine Kinase from a Bacterial Expression System Archives of Biochemistry and Biophysics. 345: 135-142. PMID 9281320 DOI: 10.1006/Abbi.1997.0236 |
0.513 |
|
| 1997 |
Sun G, Ke S, Budde RJA. Csk phosphorylation and inactivation in vitro by the cAMP-dependent protein kinase Archives of Biochemistry and Biophysics. 343: 194-200. PMID 9224730 DOI: 10.1006/Abbi.1997.0156 |
0.583 |
|
| 1997 |
Sun G, Budde RJA. Requirement for an additional divalent metal cation to activate protein tyrosine kinases. Biochemistry. 36: 2139-2146. PMID 9047313 DOI: 10.1021/Bi962291N |
0.457 |
|
| 1995 |
Li S, Sun G, Budde RJA. Production and Characterization of Monoclonal Antibodies against the Recombinant p50csk Protein Tyrosine Kinase: A Tool for Signal Transduction Research Hybridoma. 14: 341-346. PMID 8522345 DOI: 10.1089/Hyb.1995.14.341 |
0.517 |
|
| 1993 |
Sun G, Sarath G, Markwell J. Phosphopeptides as substrates for thylakoid protein phosphatase activity Archives of Biochemistry and Biophysics. 304: 490-495. PMID 8394059 DOI: 10.1006/Abbi.1993.1380 |
0.43 |
|
| 1992 |
Sun G, Markwell J. Lack of Types 1 and 2A Protein Serine(P)/Threonine(P) Phosphatase Activities in Chloroplasts. Plant Physiology. 100: 620-624. PMID 16653037 DOI: 10.1104/Pp.100.2.620 |
0.395 |
|
| 1989 |
Sun G, Bailey D, Jones MW, Markwell J. Chloroplast Thylakoid Protein Phosphatase Is a Membrane Surface-Associated Activity Plant Physiology. 89: 238-243. PMID 16666520 DOI: 10.1104/Pp.89.1.238 |
0.349 |
|
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