| Year |
Citation |
Score |
| 2023 |
Jayaraman S, Wu X, Kalari KR, Tang X, Kuffel MJ, Bruinsma ES, Jalali S, Peterson KL, Correia C, Kudgus RA, Kaufmann SH, Renuse S, Ingle JN, Reid JM, Ames MM, ... Fields AP, et al. Endoxifen downregulates AKT phosphorylation through protein kinase C beta 1 inhibition in ERα+ breast cancer. Npj Breast Cancer. 9: 101. PMID 38114522 DOI: 10.1038/s41523-023-00606-2 |
0.36 |
|
| 2022 |
Inman KS, Liu Y, Scotti Buzhardt ML, Leitges M, Krishna M, Crawford HC, Fields AP, Murray NR. Regulates Autophagy and Pancreatic Tumorigenesis in Mice. Cancers. 14. PMID 35159064 DOI: 10.3390/cancers14030796 |
0.326 |
|
| 2021 |
Kenchappa RS, Liu Y, Argenziano MG, Banu MA, Mladek AC, West R, Luu A, Quiñones-Hinojosa A, Hambardzumyan D, Justilien V, Leitges M, Sarkaria JN, Sims PA, Canoll P, Murray NR, ... Fields AP, et al. Protein kinase C and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities. Cell Reports. 37: 110054. PMID 34818553 DOI: 10.1016/j.celrep.2021.110054 |
0.349 |
|
| 2021 |
Cook DR, Kang M, Martin TD, Galanko JA, Loeza GH, Trembath DG, Justilien V, Pickering KA, Vincent DF, Jarosch A, Jurmeister P, Waters AM, Hibshman PS, Campbell AD, Ford CA, ... ... Fields AP, et al. Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth. Cancer Research. PMID 34737214 DOI: 10.1158/0008-5472.CAN-20-4218 |
0.355 |
|
| 2020 |
Limzerwala JF, Jeganathan KB, Kloeber JA, Davies BA, Zhang C, Sturmlechner I, Zhong J, Velasco RF, Fields AP, Yuan Y, Baker DJ, Zhou D, Li H, Katzmann DJ, van Deursen JM. FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer. Nature Cancer. 1: 1010-1024. PMID 34841254 DOI: 10.1038/s43018-020-00116-1 |
0.32 |
|
| 2020 |
Liu Y, Justilien V, Fields AP, Murray NR. Recurrent copy number gains drive PKCι expression and PKCι-dependent oncogenic signaling in human cancers. Advances in Biological Regulation. 78: 100754. PMID 32992230 DOI: 10.1016/J.Jbior.2020.100754 |
0.454 |
|
| 2020 |
Justilien V, Lewis KC, Meneses KM, Jamieson L, Murray NR, Fields AP. Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small cell lung cancer cells. The Journal of Biological Chemistry. PMID 32350115 DOI: 10.1074/Jbc.Ra120.013175 |
0.485 |
|
| 2020 |
Liu Y, Yin N, Wang X, Khoor A, Sambandam V, Ghosh AB, Fields ZA, Murray NR, Justilien V, Fields AP. Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma. Cell Reports. 30: 771-782.e6. PMID 31968252 DOI: 10.1016/J.Celrep.2019.12.071 |
0.413 |
|
| 2019 |
Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP. Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma. Cancer Cell. 36: 692-693. PMID 31821786 DOI: 10.1016/J.Ccell.2019.11.007 |
0.386 |
|
| 2019 |
Yin N, Liu Y, Murray NR, Fields AP. Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies. Advances in Biological Regulation. 100656. PMID 31623973 DOI: 10.1016/J.Jbior.2019.100656 |
0.473 |
|
| 2019 |
Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP. Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma. Cancer Cell. PMID 31378680 DOI: 10.1016/J.Ccell.2019.07.002 |
0.465 |
|
| 2019 |
Kenchappa R, Luu A, West R, Mladek A, Sarkaria J, Liu Y, Murray N, Fields A, Rosenfeld S. CSIG-13. PROTEIN KINASE CI DRIVES BOTH TUMOR INVASION AND PROLIFERATION AND IS A COMPELLING TARGET FOR THE TREATMENT OF GLIOBLASTOMA Neuro-Oncology. 21: vi46-vi46. DOI: 10.1093/Neuonc/Noz175.1189 |
0.448 |
|
| 2018 |
Fields AP, Ali SA, Justilien V, Murray NR. Protein kinase C: A versatile oncogene in the lung. Molecular & Cellular Oncology. 5: e1190886. PMID 30263934 DOI: 10.1080/23723556.2016.1190886 |
0.47 |
|
| 2018 |
Wen HJ, Walsh MP, Yan IK, Takahashi K, Fields A, Patel T. Functional Modulation of Gene Expression by Ultraconserved Long Non-coding RNA TUC338 during Growth of Human Hepatocellular Carcinoma. Iscience. 2: 210-220. PMID 29888750 DOI: 10.1016/J.Isci.2018.03.004 |
0.331 |
|
| 2017 |
Justilien V, Lewis KC, Murray NR, Fields AP. Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC. Small Gtpases. 0. PMID 28657426 DOI: 10.1080/21541248.2017.1335274 |
0.487 |
|
| 2017 |
Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP. Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma. Cancer Cell. PMID 28110998 DOI: 10.1016/J.Ccell.2016.12.010 |
0.441 |
|
| 2017 |
Murray N, Justilien V, Fields A. PUB055 The 3q26 OncCassette: A Multigenic Driver of Lung Cancer Journal of Thoracic Oncology. 12: S1480. DOI: 10.1016/J.Jtho.2016.11.2025 |
0.337 |
|
| 2017 |
Ross H, Justilien V, Fields A. P2.06-009 Combined PKC i and mTOR Inhibition in Advanced or Recurrent Lung Cancer, Preliminary Report of an Ongoing Phase I/II Trial Journal of Thoracic Oncology. 12: S1074. DOI: 10.1016/J.Jtho.2016.11.1502 |
0.359 |
|
| 2016 |
Murray NR, Justilien V, Fields AP. SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse. Cancer Cell. 30: 505-507. PMID 27728797 DOI: 10.1016/J.Ccell.2016.09.012 |
0.408 |
|
| 2016 |
Wang Y, Justilien V, Brennan KI, Jamieson L, Murray NR, Fields AP. PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis. Oncogene. PMID 27321186 DOI: 10.1038/Onc.2016.224 |
0.517 |
|
| 2016 |
Fields AP, Ali SA, Murray NR. Oncogenic PKCι decides tumor-initiating cell fate. Cell Cycle (Georgetown, Tex.). 0. PMID 27315374 DOI: 10.1080/15384101.2016.1194624 |
0.353 |
|
| 2016 |
Fields AP, Ali SA, Justilien V, Murray NR. Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC. Small Gtpases. 0. PMID 27245608 DOI: 10.1080/21541248.2016.1194953 |
0.485 |
|
| 2016 |
Riabov V, Yin S, Song B, Avdic A, Schledzewski K, Ovsiy I, Gratchev A, Llopis Verdiell M, Sticht C, Schmuttermaier C, Schönhaber H, Weiss C, Fields AP, Simon-Keller K, Pfister F, et al. Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model. Oncotarget. PMID 27105498 DOI: 10.18632/Oncotarget.8857 |
0.397 |
|
| 2016 |
Ali SA, Justilien V, Jamieson L, Murray NR, Fields AP. Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma. Cancer Cell. 29: 367-78. PMID 26977885 DOI: 10.1016/J.Ccell.2016.02.012 |
0.494 |
|
| 2015 |
Fields AP, Justilien V, Murray NR. The chromosome 3q26 OncCassette: A multigenic driver of human cancer. Advances in Biological Regulation. PMID 26754874 DOI: 10.1016/J.Jbior.2015.10.009 |
0.31 |
|
| 2015 |
Butler AM, Scotti Buzhardt ML, Erdogan E, Li S, Inman KS, Fields AP, Murray NR. A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion. Oncotarget. 6: 15297-310. PMID 25915428 DOI: 10.18632/Oncotarget.3812 |
0.657 |
|
| 2015 |
Liou GY, Döppler H, Braun UB, Panayiotou R, Scotti Buzhardt M, Radisky DC, Crawford HC, Fields AP, Murray NR, Wang QJ, Leitges M, Storz P. Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nature Communications. 6: 6200. PMID 25698580 DOI: 10.1038/Ncomms7200 |
0.417 |
|
| 2015 |
Justilien V, Fields AP. Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 505-13. PMID 25646180 DOI: 10.1158/1078-0432.Ccr-14-0507 |
0.433 |
|
| 2015 |
Jatoi A, Radecki Breitkopf C, Foster NR, Block MS, Grudem M, Wahner Hendrickson A, Carlson RE, Barrette B, Karlin N, Fields AP. A mixed-methods feasibility trial of protein kinase C iota inhibition with auranofin in asymptomatic ovarian cancer patients. Oncology. 88: 208-13. PMID 25502607 DOI: 10.1159/000369257 |
0.366 |
|
| 2014 |
Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, Fields AP. The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer Cell. 25: 139-51. PMID 24525231 DOI: 10.1016/J.Ccr.2014.01.008 |
0.429 |
|
| 2014 |
Parker PJ, Justilien V, Riou P, Linch M, Fields AP. Atypical protein kinase Cι as a human oncogene and therapeutic target. Biochemical Pharmacology. 88: 1-11. PMID 24231509 DOI: 10.1016/J.Bcp.2013.10.023 |
0.507 |
|
| 2014 |
Hill KS, Erdogan E, Khoor A, Walsh MP, Leitges M, Murray NR, Fields AP. Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis. Oncogene. 33: 2134-44. PMID 23604119 DOI: 10.1038/Onc.2013.147 |
0.486 |
|
| 2014 |
Justilien V, Walsh MP, Ali SA, Thompson EA, Fields AP. Abstract B02: Protein Kinase C iota is required for the maintenance of a tumor-initiating cell phenotype in lung squamous cell carcinoma. Clinical Cancer Research. 20: B02-B02. DOI: 10.1158/1078-0432.14AACRIASLC-B02 |
0.321 |
|
| 2013 |
Justilien V, Fields AP. Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 62: Unit 14.27.. PMID 24510718 DOI: 10.1002/0471141755.Ph1427S62 |
0.401 |
|
| 2013 |
Wang Y, Hill KS, Fields AP. PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis. Molecular Cancer Research : McR. 11: 1624-35. PMID 24174471 DOI: 10.1158/1541-7786.Mcr-13-0371-T |
0.493 |
|
| 2013 |
Butler AM, Scotti Buzhardt ML, Li S, Smith KE, Fields AP, Murray NR. Protein kinase C zeta regulates human pancreatic cancer cell transformed growth and invasion through a STAT3-dependent mechanism. Plos One. 8: e72061. PMID 24015205 DOI: 10.1371/Journal.Pone.0072061 |
0.678 |
|
| 2013 |
Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei AA, Erlichman C, Molina JR. Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer. Anti-Cancer Drugs. 24: 1079-83. PMID 23962904 DOI: 10.1097/Cad.0000000000000009 |
0.358 |
|
| 2013 |
Greer YE, Fields AP, Brown AM, Rubin JS. Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated dishevelled 2. The Journal of Biological Chemistry. 288: 9438-46. PMID 23396968 DOI: 10.1074/Jbc.M112.448282 |
0.415 |
|
| 2013 |
Kikuchi K, Soundararajan A, Zarzabal LA, Weems CR, Nelon LD, Hampton ST, Michalek JE, Rubin BP, Fields AP, Keller C. Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma. Oncogene. 32: 286-95. PMID 22349825 DOI: 10.1038/Onc.2012.46 |
0.498 |
|
| 2013 |
Deng X, Cao Y, Liu Y, Li F, Sambandam K, Rajaraman S, Perkins AS, Fields AP, Hellmich MR, Townsend CM, Thompson EA, Ko TC. Overexpression of Evi-1 oncoprotein represses TGF-β signaling in colorectal cancer. Molecular Carcinogenesis. 52: 255-64. PMID 22161860 DOI: 10.1002/Mc.21852 |
0.362 |
|
| 2013 |
Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei AA, Erlichman C, Molina JR. Phase I dose escalation study of the protein kinase C iota inhibitor aurothiomalate for advanced non-small cell lung cancer, ovarian cancer, and pancreatic cancer. Journal of Clinical Oncology. 31: 2551-2551. DOI: 10.1200/Jco.2013.31.15_Suppl.2551 |
0.332 |
|
| 2012 |
Stallings-Mann ML, Waldmann J, Zhang Y, Miller E, Gauthier ML, Visscher DW, Downey GP, Radisky ES, Fields AP, Radisky DC. Matrix metalloproteinase induction of Rac1b, a key effector of lung cancer progression. Science Translational Medicine. 4: 142ra95. PMID 22786680 DOI: 10.1126/Scitranslmed.3004062 |
0.438 |
|
| 2012 |
Kalari KR, Rossell D, Necela BM, Asmann YW, Nair A, Baheti S, Kachergus JM, Younkin CS, Baker T, Carr JM, Tang X, Walsh MP, Chai HS, Sun Z, Hart SN, ... ... Fields AP, et al. Deep Sequence Analysis of Non-Small Cell Lung Cancer: Integrated Analysis of Gene Expression, Alternative Splicing, and Single Nucleotide Variations in Lung Adenocarcinomas with and without Oncogenic KRAS Mutations. Frontiers in Oncology. 2: 12. PMID 22655260 DOI: 10.3389/Fonc.2012.00012 |
0.39 |
|
| 2012 |
Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP. Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. Plos One. 7: e35040. PMID 22545096 DOI: 10.1371/Journal.Pone.0035040 |
0.419 |
|
| 2012 |
Scotti ML, Smith KE, Butler AM, Calcagno SR, Crawford HC, Leitges M, Fields AP, Murray NR. Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. Plos One. 7: e30509. PMID 22359542 DOI: 10.1371/Journal.Pone.0030509 |
0.599 |
|
| 2012 |
Justilien V, Fields AP. Atypical Protein Kinase C Signaling in Cancer Aacr Education Book. 2012: 17-22. DOI: 10.1158/AACR.EDB-12-8421 |
0.332 |
|
| 2012 |
Butler AM, Scotti ML, Li S, Fields AP, Murray NR. Abstract B63: Protein kinase C zeta plays an important role in the oncogenic phenotype of pancreatic cancer cells. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B63 |
0.656 |
|
| 2012 |
Justilien V, Regala RP, Tseng I, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP. Abstract LB-204: Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-204 |
0.447 |
|
| 2011 |
O'Neill AK, Gallegos LL, Justilien V, Garcia EL, Leitges M, Fields AP, Hall RA, Newton AC. Protein kinase Cα promotes cell migration through a PDZ-dependent interaction with its novel substrate discs large homolog 1 (DLG1). The Journal of Biological Chemistry. 286: 43559-68. PMID 22027822 DOI: 10.1074/Jbc.M111.294603 |
0.453 |
|
| 2011 |
Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP. Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. Plos One. 6: e26439. PMID 22022614 DOI: 10.1371/Journal.Pone.0026439 |
0.405 |
|
| 2011 |
Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. The Journal of Biological Chemistry. 286: 8149-57. PMID 21189248 DOI: 10.1074/Jbc.M110.196113 |
0.479 |
|
| 2011 |
Murray NR, Kalari KR, Fields AP. Protein kinase Cι expression and oncogenic signaling mechanisms in cancer. Journal of Cellular Physiology. 226: 879-87. PMID 20945390 DOI: 10.1002/Jcp.22463 |
0.498 |
|
| 2011 |
Kalari KR, Rossell D, Asmann Y, Nair A, Baker T, Carr J, Chai H, Hossain A, Sun Z, Li Y, Middha S, Bot B, Passow JE, Kocher J, Perez E, ... Fields A, et al. Abstract 4975: Next generation sequencing reveals a connection between KRAS mutation and the NFkB pathway in lung adenocarcinoma samples Cancer Research. 71: 4975-4975. DOI: 10.1158/1538-7445.Am2011-4975 |
0.385 |
|
| 2011 |
Kikuchi K, Soundararajan A, Zarzabal LA, Weems CR, Nelson LD, Hampton ST, Michalek JA, Rubin BP, Fields AP, Keller C. Abstract 1043: Role of protein kinase Cι in alveolar rhabdomyosarcoma Cancer Research. 71: 1043-1043. DOI: 10.1158/1538-7445.Am2011-1043 |
0.488 |
|
| 2010 |
Berg TJ, Gastonguay AJ, Lorimer EL, Kuhnmuench JR, Li R, Fields AP, Williams CL. Splice variants of SmgGDS control small GTPase prenylation and membrane localization. The Journal of Biological Chemistry. 285: 35255-66. PMID 20709748 DOI: 10.1074/Jbc.M110.129916 |
0.391 |
|
| 2010 |
Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR. Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Research. 70: 2064-74. PMID 20179210 DOI: 10.1158/0008-5472.Can-09-2684 |
0.502 |
|
| 2010 |
Fields AP, Justilien V. The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Advances in Enzyme Regulation. 50: 190-200. PMID 19896966 DOI: 10.1016/J.Advenzreg.2009.10.010 |
0.484 |
|
| 2009 |
Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP. Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Cancer Research. 69: 7603-11. PMID 19738040 DOI: 10.1158/0008-5472.Can-09-2066 |
0.47 |
|
| 2009 |
Justilien V, Fields AP. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene. 28: 3597-607. PMID 19617897 DOI: 10.1038/Onc.2009.217 |
0.474 |
|
| 2009 |
Erdogan E, Klee EW, Thompson EA, Fields AP. Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1527-33. PMID 19223491 DOI: 10.1158/1078-0432.Ccr-08-2459 |
0.426 |
|
| 2009 |
Fields AP, Calcagno SR, Krishna M, Rak S, Leitges M, Murray NR. Protein kinase Cbeta is an effective target for chemoprevention of colon cancer. Cancer Research. 69: 1643-50. PMID 19221092 DOI: 10.1158/0008-5472.Can-08-3187 |
0.472 |
|
| 2009 |
Murray NR, Weems J, Braun U, Leitges M, Fields AP. Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer Research. 69: 656-62. PMID 19147581 DOI: 10.1158/0008-5472.Can-08-3001 |
0.401 |
|
| 2008 |
Regala RP, Thompson EA, Fields AP. Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells. Cancer Research. 68: 5888-95. PMID 18632643 DOI: 10.1158/0008-5472.Can-08-0438 |
0.513 |
|
| 2008 |
Su W, Necela BM, Fujiwara K, Kurakata S, Murray NR, Fields AP, Thompson EA. The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice. International Journal of Cancer. Journal International Du Cancer. 123: 991-7. PMID 18546290 DOI: 10.1002/Ijc.23640 |
0.309 |
|
| 2008 |
Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene. 27: 4841-53. PMID 18427549 DOI: 10.1038/Onc.2008.119 |
0.428 |
|
| 2008 |
Calcagno SR, Li S, Colon M, Kreinest PA, Thompson EA, Fields AP, Murray NR. Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon. International Journal of Cancer. Journal International Du Cancer. 122: 2462-70. PMID 18271008 DOI: 10.1002/Ijc.23383 |
0.324 |
|
| 2008 |
Fields AP, Murray NR. Protein kinase C isozymes as therapeutic targets for treatment of human cancers. Advances in Enzyme Regulation. 48: 166-78. PMID 18167314 DOI: 10.1016/J.Advenzreg.2007.11.014 |
0.439 |
|
| 2007 |
Rudolph JL, Shi GX, Erdogan E, Fields AP, Andres DA. Rit mutants confirm role of MEK/ERK signaling in neuronal differentiation and reveal novel Par6 interaction. Biochimica Et Biophysica Acta. 1773: 1793-800. PMID 17976838 DOI: 10.1016/J.Bbamcr.2007.09.008 |
0.398 |
|
| 2007 |
Fields AP, Frederick LA, Regala RP. Targeting the oncogenic protein kinase Ciota signalling pathway for the treatment of cancer. Biochemical Society Transactions. 35: 996-1000. PMID 17956262 DOI: 10.1042/BST0350996 |
0.423 |
|
| 2007 |
Fields AP, Regala RP. Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. Pharmacological Research. 55: 487-97. PMID 17570678 DOI: 10.1016/J.Phrs.2007.04.015 |
0.508 |
|
| 2007 |
Su W, Bush CR, Necela BM, Calcagno SR, Murray NR, Fields AP, Thompson EA. Differential expression, distribution, and function of PPAR-gamma in the proximal and distal colon. Physiological Genomics. 30: 342-53. PMID 17519361 DOI: 10.1152/Physiolgenomics.00042.2007 |
0.362 |
|
| 2006 |
Erdogan E, Lamark T, Stallings-Mann M, Lee Jamieson, Pellecchia M, Pellechia M, Thompson EA, Johansen T, Fields AP. Aurothiomalate inhibits transformed growth by targeting the PB1 domain of protein kinase Ciota. The Journal of Biological Chemistry. 281: 28450-9. PMID 16861740 DOI: 10.1074/Jbc.M606054200 |
0.4 |
|
| 2006 |
Chen L, Necela BM, Su W, Yanagisawa M, Anastasiadis PZ, Fields AP, Thompson EA. Peroxisome proliferator-activated receptor gamma promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2. The Journal of Biological Chemistry. 281: 24575-87. PMID 16815847 DOI: 10.1074/Jbc.M604147200 |
0.439 |
|
| 2006 |
Chen L, Bush CR, Necela BM, Su W, Yanagisawa M, Anastasiadis PZ, Fields AP, Thompson EA. RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells. Molecular and Cellular Endocrinology. 251: 17-32. PMID 16574311 DOI: 10.1016/J.Mce.2006.02.006 |
0.382 |
|
| 2006 |
Liu Y, Chen L, Ko TC, Fields AP, Thompson EA. Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT. Oncogene. 25: 3565-75. PMID 16462766 DOI: 10.1038/Sj.Onc.1209403 |
0.481 |
|
| 2006 |
Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR, Fields AP. A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Research. 66: 1767-74. PMID 16452237 DOI: 10.1158/0008-5472.Can-05-3405 |
0.483 |
|
| 2005 |
Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM, Fields AP. Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Research. 65: 8905-11. PMID 16204062 DOI: 10.1158/0008-5472.Can-05-2372 |
0.48 |
|
| 2005 |
Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA, Fields AP. Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. The Journal of Biological Chemistry. 280: 31109-15. PMID 15994303 DOI: 10.1074/Jbc.M505402200 |
0.522 |
|
| 2004 |
Liu Y, Su W, Thompson EA, Leitges M, Murray NR, Fields AP. Protein kinase CbetaII regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo. The Journal of Biological Chemistry. 279: 45556-63. PMID 15322124 DOI: 10.1074/Jbc.M407701200 |
0.446 |
|
| 2004 |
Ray S, Lu Y, Kaufmann SH, Gustafson WC, Karp JE, Boldogh I, Fields AP, Brasier AR. Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. The Journal of Biological Chemistry. 279: 35604-15. PMID 15155749 DOI: 10.1074/Jbc.M401851200 |
0.391 |
|
| 2004 |
Zhang J, Anastasiadis PZ, Liu Y, Thompson EA, Fields AP. Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway. The Journal of Biological Chemistry. 279: 22118-23. PMID 15037605 DOI: 10.1074/Jbc.M400774200 |
0.491 |
|
| 2004 |
Murray NR, Jamieson L, Yu W, Zhang J, Gökmen-Polar Y, Sier D, Anastasiadis P, Gatalica Z, Thompson EA, Fields AP. Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo. The Journal of Cell Biology. 164: 797-802. PMID 15024028 DOI: 10.1083/Jcb.200311011 |
0.365 |
|
| 2004 |
Gustafson WC, Ray S, Jamieson L, Thompson EA, Brasier AR, Fields AP. Bcr-Abl regulates protein kinase Ciota (PKCiota) transcription via an Elk1 site in the PKCiota promoter. The Journal of Biological Chemistry. 279: 9400-8. PMID 14670960 DOI: 10.1074/Jbc.M312840200 |
0.464 |
|
| 2003 |
Fields AP, Murray NR, Gustafson WC. Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models. Methods in Molecular Biology (Clifton, N.J.). 233: 539-53. PMID 12840533 DOI: 10.1385/1-59259-397-6:539 |
0.386 |
|
| 2003 |
Fields AP, Gustafson WC. Protein kinase C in disease: cancer. Methods in Molecular Biology (Clifton, N.J.). 233: 519-37. PMID 12840532 DOI: 10.1385/1-59259-397-6:519 |
0.403 |
|
| 2003 |
Davidson LA, Lupton JR, Miskovsky E, Fields AP, Chapkin RS. Quantification of human intestinal gene expression profiles using exfoliated colonocytes: a pilot study. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 8: 51-61. PMID 12519636 DOI: 10.1080/1354750021000042268 |
0.339 |
|
| 2003 |
Yu W, Murray NR, Weems C, Chen L, Guo H, Ethridge R, Ceci JD, Evers BM, Thompson EA, Fields AP. Role of cyclooxygenase 2 in protein kinase C beta II-mediated colon carcinogenesis. The Journal of Biological Chemistry. 278: 11167-74. PMID 12480928 DOI: 10.1074/Jbc.M211424200 |
0.323 |
|
| 2002 |
Murray NR, Weems C, Chen L, Leon J, Yu W, Davidson LA, Jamieson L, Chapkin RS, Thompson EA, Fields AP. Protein kinase C betaII and TGFbetaRII in omega-3 fatty acid-mediated inhibition of colon carcinogenesis. The Journal of Cell Biology. 157: 915-20. PMID 12058013 DOI: 10.1083/Jcb.200201127 |
0.41 |
|
| 2001 |
Lu Y, Jamieson L, Brasier AR, Fields AP. NF-kappaB/RelA transactivation is required for atypical protein kinase C iota-mediated cell survival. Oncogene. 20: 4777-92. PMID 11521190 DOI: 10.1038/Sj.Onc.1204607 |
0.437 |
|
| 2001 |
Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP. Cloning of a novel phosphatidylinositol kinase-related kinase. Characterization of the human SMG-1 RNA surveillance protein Journal of Biological Chemistry. 276: 22709-22714. PMID 11331269 DOI: 10.1074/Jbc.C100144200 |
0.402 |
|
| 2001 |
Sindić A, Aleksandrova A, Fields AP, Volinia S, Banfić H. Presence and activation of nuclear phosphoinositide 3-kinase C2beta during compensatory liver growth. The Journal of Biological Chemistry. 276: 17754-61. PMID 11278304 DOI: 10.1074/Jbc.M006533200 |
0.306 |
|
| 2001 |
Gökmen-Polar Y, Murray NR, Velasco MA, Gatalica Z, Fields AP. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Research. 61: 1375-81. PMID 11245437 |
0.362 |
|
| 2000 |
Ray A, Fields AP, Ray BK. Activation of transcription factor SAF involves its phosphorylation by protein kinase C. The Journal of Biological Chemistry. 275: 39727-33. PMID 10995778 DOI: 10.1074/Jbc.M007907200 |
0.44 |
|
| 2000 |
Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. American Journal of Physiology. Lung Cellular and Molecular Physiology. 279: L429-38. PMID 10956616 DOI: 10.1152/Ajplung.2000.279.3.L429 |
0.46 |
|
| 1999 |
Murray NR, Davidson LA, Chapkin RS, Clay Gustafson W, Schattenberg DG, Fields AP. Overexpression of protein kinase C betaII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. The Journal of Cell Biology. 145: 699-711. PMID 10330400 DOI: 10.1083/Jcb.145.4.699 |
0.412 |
|
| 1999 |
Jamieson L, Carpenter L, Biden TJ, Fields AP. Protein kinase Ciota activity is necessary for Bcr-Abl-mediated resistance to drug-induced apoptosis. The Journal of Biological Chemistry. 274: 3927-30. PMID 9933579 DOI: 10.1074/Jbc.274.7.3927 |
0.363 |
|
| 1999 |
Li Q, Subbulakshmi V, Fields AP, Murray NR, Cathcart MK. Protein kinase calpha regulates human monocyte O-2 production and low density lipoprotein lipid oxidation. The Journal of Biological Chemistry. 274: 3764-71. PMID 9920929 DOI: 10.1074/Jbc.274.6.3764 |
0.31 |
|
| 1998 |
Korytko AI, Fields AP, Allshouse LA, Cuttler L. Pituitary expression of protein kinase C isotypes during early development. Journal of Neuroendocrinology. 10: 569-76. PMID 9725708 DOI: 10.1046/J.1365-2826.1998.00201.X |
0.347 |
|
| 1998 |
Gökmen-Polar Y, Fields AP. Mapping of a molecular determinant for protein kinase C betaII isozyme function. The Journal of Biological Chemistry. 273: 20261-6. PMID 9685375 DOI: 10.1074/Jbc.273.32.20261 |
0.388 |
|
| 1998 |
Murray NR, Fields AP. Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C. The Journal of Biological Chemistry. 273: 11514-20. PMID 9565565 DOI: 10.1074/Jbc.273.19.11514 |
0.373 |
|
| 1997 |
Thompson LJ, Bollen M, Fields AP. Identification of protein phosphatase 1 as a mitotic lamin phosphatase. The Journal of Biological Chemistry. 272: 29693-7. PMID 9368037 DOI: 10.1074/Jbc.272.47.29693 |
0.385 |
|
| 1997 |
Murray NR, Fields AP. Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. The Journal of Biological Chemistry. 272: 27521-4. PMID 9346882 DOI: 10.1074/Jbc.272.44.27521 |
0.411 |
|
| 1997 |
Sun B, Murray NR, Fields AP. A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition. The Journal of Biological Chemistry. 272: 26313-7. PMID 9334202 DOI: 10.1074/Jbc.272.42.26313 |
0.34 |
|
| 1997 |
Collas P, Thompson L, Fields AP, Poccia DL, Courvalin JC. Protein kinase C-mediated interphase lamin B phosphorylation and solubilization. The Journal of Biological Chemistry. 272: 21274-80. PMID 9261138 DOI: 10.1074/Jbc.272.34.21274 |
0.353 |
|
| 1996 |
Thompson LJ, Fields AP. betaII protein kinase C is required for the G2/M phase transition of cell cycle. The Journal of Biological Chemistry. 271: 15045-53. PMID 8663071 DOI: 10.1074/Jbc.271.25.15045 |
0.405 |
|
| 1996 |
Murray NR, Walker SD, Burns DJ, Fields AP. Identification of molecular determinants for protein kinase c isotype-specific functions in human leukemia cell proliferation and differentiation Faseb Journal. 10: A1513. |
0.346 |
|
| 1995 |
Fields AP, Thompson LJ. The regulation of mitotic nuclear envelope breakdown: a role for multiple lamin kinases. Progress in Cell Cycle Research. 1: 271-86. PMID 9552370 DOI: 10.1007/978-1-4615-1809-9_22 |
0.386 |
|
| 1995 |
Mallia CM, Jeter JR, Fields AP, Wilson RB, Beckman BS. Protein kinase C beta from Friend erythroleukemia cells is associated with chromatin and DNA. Molecular and Cellular Biochemistry. 151: 107-11. PMID 8569755 DOI: 10.1007/Bf01322332 |
0.345 |
|
| 1995 |
Huntley CC, De BP, Murray NR, Fields AP, Banerjee AK. Human parainfluenza virus type 3 phosphoprotein: identification of serine 333 as the major site for PKC zeta phosphorylation. Virology. 211: 561-7. PMID 7645259 DOI: 10.1006/Viro.1995.1438 |
0.341 |
|
| 1995 |
Walker SD, Murray NR, Burns DJ, Fields AP. Protein kinase C chimeras: catalytic domains of alpha and beta II protein kinase C contain determinants for isotype-specific function. Proceedings of the National Academy of Sciences of the United States of America. 92: 9156-60. PMID 7568092 DOI: 10.1073/Pnas.92.20.9156 |
0.314 |
|
| 1993 |
Saxena R, Saksa BA, Fields AP, Ganz MB. Activation of Na/H exchanger in mesangial cells is associated with translocation of PKC isoforms. The American Journal of Physiology. 265: F53-60. PMID 8393624 DOI: 10.1152/Ajprenal.1993.265.1.F53 |
0.322 |
|
| 1992 |
Hocevar BA, Morrow DM, Tykocinski ML, Fields AP. Protein kinase C isotypes in human erythroleukemia cell proliferation and differentiation. Journal of Cell Science. 101: 671-9. PMID 1522149 |
0.323 |
|
| 1992 |
Misra-Press A, Fields AP, Samols D, Goldthwait DA. Protein kinase C isoforms in human glioblastoma cells. Glia. 6: 188-97. PMID 1335968 DOI: 10.1002/Glia.440060306 |
0.339 |
|
| 1988 |
Fields AP, Pettit GR, May WS. Phosphorylation of lamin B at the nuclear membrane by activated protein kinase C Journal of Biological Chemistry. 263: 8253-8260. PMID 3163693 |
0.318 |
|
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