| Year |
Citation |
Score |
| 2023 |
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state, and its deletion improves checkpoint blockade. Cell Reports. 42: 112905. PMID 37527035 DOI: 10.1016/j.celrep.2023.112905 |
0.343 |
|
| 2023 |
McClory SE, Bardhan O, Rome KS, Giles JR, Baxter AE, Xu L, Gimotty PA, Faryabi RB, Wherry EJ, Pear WS, Jordan MS. The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state and its deletion improves checkpoint blockade. Biorxiv : the Preprint Server For Biology. PMID 36824931 DOI: 10.1101/2023.02.16.528833 |
0.37 |
|
| 2022 |
Gómez Atria D, Gaudette BT, Londregan J, Kelly S, Perkey E, Allman A, Srivastava B, Koch U, Radtke F, Ludewig B, Siebel CW, Ryan RJ, Robertson TF, Burkhardt JK, Pear WS, et al. Stromal Notch ligands foster lymphopenia-driven functional plasticity and homeostatic proliferation of naïve B cells. The Journal of Clinical Investigation. PMID 35579963 DOI: 10.1172/JCI158885 |
0.358 |
|
| 2020 |
Kobia FM, Preusse K, Dai Q, Weaver N, Hass MR, Chaturvedi P, Stein SJ, Pear WS, Yuan Z, Kovall RA, Kuang Y, Eafergen N, Sprinzak D, Gebelein B, Brunskill EW, et al. Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. Plos Biology. 18: e3000850. PMID 33017398 DOI: 10.1371/journal.pbio.3000850 |
0.349 |
|
| 2020 |
Zheng Q, Capell B, Parekh V, O'Day C, Atillasoy C, Bashir HM, Yeh C, Shim EH, Prouty SM, Dentchev T, Lee V, Wushanley L, Kweon Y, Suzuki-Horiuchi Y, Pear W, et al. Whole exome and transcriptome analysis of UV-exposed epidermis and carcinoma in situ reveals early drivers of carcinogenesis. The Journal of Investigative Dermatology. PMID 32649944 DOI: 10.1016/J.Jid.2020.05.116 |
0.344 |
|
| 2020 |
Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, ... ... Pear WS, et al. Trib1 regulates T cell differentiation during chronic infection by restraining the effector program. The Journal of Experimental Medicine. 217. PMID 32150623 DOI: 10.1084/Jem.20190888 |
0.525 |
|
| 2020 |
Schwartz GW, Zhou Y, Petrovic J, Fasolino M, Xu L, Shaffer SM, Pear WS, Vahedi G, Faryabi RB. TooManyCells identifies and visualizes relationships of single-cell clades. Nature Methods. PMID 32123397 DOI: 10.1038/S41592-020-0748-5 |
0.302 |
|
| 2020 |
Iheanacho F, Stein SJ, Rome KS, Jordan MS, Pear WS. Abstract A55: Uncovering the mechanism of Trib1 in cancer immunotherapy Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-A55 |
0.492 |
|
| 2019 |
Mack EA, Pear WS. Transcription factor and cytokine regulation of eosinophil lineage commitment. Current Opinion in Hematology. PMID 31688456 DOI: 10.1097/Moh.0000000000000552 |
0.382 |
|
| 2019 |
Mack EA, Stein SJ, Rome KS, Xu L, Wertheim GB, Melo RC, Pear WS. Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program. Blood. PMID 30917956 DOI: 10.1182/Blood.2018872218 |
0.414 |
|
| 2019 |
Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, ... ... Pear WS, et al. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Molecular Cell. PMID 30745086 DOI: 10.1016/J.Molcel.2019.01.006 |
0.359 |
|
| 2019 |
Guerrero-Juarez CF, Dedhia PH, Jin S, Ruiz-Vega R, Ma D, Liu Y, Yamaga K, Shestova O, Gay DL, Yang Z, Kessenbrock K, Nie Q, Pear WS, Cotsarelis G, Plikus MV. Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds. Nature Communications. 10: 650. PMID 30737373 DOI: 10.1038/S41467-018-08247-X |
0.37 |
|
| 2018 |
Kong G, You X, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, ... ... Pear WS, et al. Downregulating Notch counteracts Kras-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. Leukemia. PMID 30206308 DOI: 10.1038/S41375-018-0248-0 |
0.523 |
|
| 2018 |
Maillard I, Pear WS. Can genetics resolve what Notch does in HSCs? Blood. 131: 1633-1635. PMID 29650730 DOI: 10.1182/Blood-2018-02-829069 |
0.421 |
|
| 2018 |
Johnson JL, Georgakilas G, Petrovic J, Kurachi M, Cai S, Harly C, Pear WS, Bhandoola A, Wherry EJ, Vahedi G. Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells. Immunity. 48: 243-257.e10. PMID 29466756 DOI: 10.1016/J.Immuni.2018.01.012 |
0.489 |
|
| 2018 |
Petrovic J, Zhou Y, Georgakilas G, Vahedi G, Pear W, Faryabi R. Abstract P2-04-07: Triple negative breast cancer-specific chromatin conformation links Notch signal to tumor-specific transcriptional program Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P2-04-07 |
0.302 |
|
| 2017 |
Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Musuthamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, ... ... Pear WS, et al. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Science Signaling. 10. PMID 29138297 DOI: 10.1126/Scisignal.Aam6846 |
0.56 |
|
| 2017 |
Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, ... ... Pear WS, et al. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Reports. 21: 784-797. PMID 29045844 DOI: 10.1016/J.Celrep.2017.09.066 |
0.494 |
|
| 2017 |
Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. Plos One. 12: e0185762. PMID 29023469 DOI: 10.1371/Journal.Pone.0185762 |
0.54 |
|
| 2017 |
Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Science Signaling. 10. PMID 28465412 DOI: 10.1126/Scisignal.Aag1598 |
0.433 |
|
| 2017 |
Plikus MV, Guerrero-Juarez CF, Ito M, Li YR, Dedhia PH, Zheng Y, Shao M, Gay DL, Ramos R, His TC, Oh JW, Wang X, Ramirez A, Konopelski SE, Elzein A, ... ... Pear WS, et al. Regeneration of fat cells from myofibroblasts during wound healing. Science (New York, N.Y.). PMID 28059714 DOI: 10.1126/Science.Aai8792 |
0.432 |
|
| 2016 |
Kobayashi M, Nabinger S, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, et al. Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals In Early T Cell Progenitors. Stem Cells (Dayton, Ohio). PMID 28009085 DOI: 10.1002/Stem.2559 |
0.568 |
|
| 2016 |
Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annual Review of Pathology. PMID 27959635 DOI: 10.1146/Annurev-Pathol-052016-100127 |
0.419 |
|
| 2016 |
Chiang MY, Wang Q, Gormley AC, Stein SJ, Xu L, Shestova O, Aster JC, Pear WS. High selective pressure for Notch1 mutations that induce Myc in T cell acute lymphoblastic leukemia. Blood. PMID 27670423 DOI: 10.1182/Blood-2016-01-692855 |
0.512 |
|
| 2016 |
Greene M, Lai Y, Pajcini K, Bailis W, Pear WS, Lancaster E. Delta/Notch-Like EGF-Related Receptor (DNER) Is Not a Notch Ligand. Plos One. 11: e0161157. PMID 27622512 DOI: 10.1371/Journal.Pone.0161157 |
0.37 |
|
| 2016 |
Stein SJ, Mack EA, Rome KS, Pajcini KV, Ohtani T, Xu L, Li Y, Meijerink JP, Faryabi RB, Pear WS. Trib2 Suppresses Tumor Initiation in Notch-Driven T-ALL. Plos One. 11: e0155408. PMID 27191957 DOI: 10.1371/Journal.Pone.0155408 |
0.48 |
|
| 2016 |
Ryan RJ, Petrovic J, Rausch D, Lareau C, Lee W, Donohue L, Christie AL, Gillespie S, Kluk MJ, Nardi V, Faryabi RB, Hochberg EP, Weinstock DM, Bernstein BE, Aster JC, ... Pear WS, et al. Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling Blood. 128: 457-457. DOI: 10.1182/Blood.V128.22.457.457 |
0.539 |
|
| 2016 |
Ryan RJ, Petrovic J, Rausch DM, Lee W, Kluk M, Donohue L, Gillespie S, Aster JC, Pear WS, Bernstein BE. Abstract 886: Notch signaling activates B-cell specific enhancers to drive oncogene targets in B-cell lymphoma Cancer Research. 76: 886-886. DOI: 10.1158/1538-7445.Am2016-886 |
0.494 |
|
| 2016 |
Pear W, Yashiro-Ohtani Y, Petrovic J, Yu S, Mercado V, Xu L, Faryabi R, Liu XS, Aster J, Zang G. Modular domains within a super enhancer determine drug resistance in T-cell acute lymphoblastic leukemia Experimental Hematology. 44: S25. DOI: 10.1016/J.Exphem.2016.06.011 |
0.379 |
|
| 2015 |
Stein SJ, Mack EA, Rome KS, Pear WS. Tribbles in normal and malignant haematopoiesis. Biochemical Society Transactions. 43: 1112-5. PMID 26517933 DOI: 10.1042/Bst20150117 |
0.378 |
|
| 2015 |
Kiss-Toth E, Velasco G, Pear WS. Tribbles at the cross-roads…. Biochemical Society Transactions. 43: 1049-50. PMID 26517921 DOI: 10.1042/Bst20150122 |
0.303 |
|
| 2015 |
Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nature Immunology. 16: 286-95. PMID 25642823 DOI: 10.1038/Ni.3099 |
0.458 |
|
| 2015 |
Ohtani Y, Xu S, Petrovic J, Xu L, Aster JC, Pear WS. Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia Blood. 126: 44-44. DOI: 10.1182/Blood.V126.23.44.44 |
0.473 |
|
| 2015 |
Pajcini K, Xu L, Lee C, Cherry S, Pear W. Abstract 3938: MafB and ETS2 potentiate Notch signaling in T-ALL Cancer Research. 75: 3938-3938. DOI: 10.1158/1538-7445.Am2015-3938 |
0.528 |
|
| 2014 |
Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, ... ... Pear WS, et al. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 111: E4946-53. PMID 25369933 DOI: 10.1073/Pnas.1407079111 |
0.504 |
|
| 2014 |
Bailis W, Yashiro-Ohtani Y, Pear WS. Identifying direct Notch transcriptional targets using the GSI-washout assay. Methods in Molecular Biology (Clifton, N.J.). 1187: 247-54. PMID 25053495 DOI: 10.1007/978-1-4939-1139-4_19 |
0.413 |
|
| 2014 |
Dail M, Wong J, Lawrence J, O'Connor D, Nakitandwe J, Chen SC, Xu J, Lee LB, Akagi K, Li Q, Aster JC, Pear WS, Downing JR, Sampath D, Shannon K. Loss of oncogenic Notch1 with resistance to a PI3K inhibitor in T-cell leukaemia. Nature. 513: 512-6. PMID 25043004 DOI: 10.1038/Nature13495 |
0.457 |
|
| 2014 |
Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, et al. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Research. 24: 925-42. PMID 24971735 DOI: 10.1038/Cr.2014.82 |
0.33 |
|
| 2014 |
Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, ... ... Pear WS, et al. The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells. Genes & Development. 28: 576-93. PMID 24637115 DOI: 10.1101/Gad.227496.113 |
0.693 |
|
| 2014 |
Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 705-10. PMID 24374627 DOI: 10.1073/pnas.1315023111 |
0.322 |
|
| 2014 |
Wang H, Yashiro-Ohtani Y, Zang C, Wong YJ, Bailis W, Knoechel B, Bernstein B, Blacklow S, Liu XS, Pear WS, Aster JC. Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma Blood. 124: 863-863. DOI: 10.1182/Blood.V124.21.863.863 |
0.515 |
|
| 2014 |
Kong G, Chang Y, Ranheim EA, Zhou Y, Liu Y, Lambert P, Zhou L, Stanley P, Pear WS, Zhang J. Downregulating Notch Signaling in KrasG12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner Blood. 124: 261-261. DOI: 10.1182/Blood.V124.21.261.261 |
0.563 |
|
| 2013 |
De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Sultana DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nature Immunology. 14: 1277-84. PMID 24185616 DOI: 10.1038/Ni.2760 |
0.582 |
|
| 2013 |
Bailis W, Yashiro-Ohtani Y, Fang TC, Hatton RD, Weaver CT, Artis D, Pear WS. Notch simultaneously orchestrates multiple helper T cell programs independently of cytokine signals. Immunity. 39: 148-59. PMID 23890069 DOI: 10.1016/J.Immuni.2013.07.006 |
0.689 |
|
| 2013 |
Clarke RL, Yzaguirre AD, Yashiro-Ohtani Y, Bondue A, Blanpain C, Pear WS, Speck NA, Keller G. The expression of Sox17 identifies and regulates haemogenic endothelium. Nature Cell Biology. 15: 502-10. PMID 23604320 DOI: 10.1038/Ncb2724 |
0.469 |
|
| 2013 |
Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J, Haczku A, Pear WS, Artis D, Bhandoola A. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 38: 694-704. PMID 23601684 DOI: 10.1016/J.Immuni.2012.12.003 |
0.521 |
|
| 2013 |
Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 23: 390-405. PMID 23434461 DOI: 10.1016/J.Ccr.2013.01.015 |
0.364 |
|
| 2013 |
Lin S, Shen H, Jin B, Gu Y, Chen Z, Cao C, Hu C, Keller C, Pear WS, Wu L. Brief report: Blockade of Notch signaling in muscle stem cells causes muscular dystrophic phenotype and impaired muscle regeneration. Stem Cells (Dayton, Ohio). 31: 823-8. PMID 23307608 DOI: 10.1002/Stem.1319 |
0.374 |
|
| 2013 |
Zhang Y, Lam O, Nguyen MT, Ng G, Pear WS, Ai W, Wang IJ, Kao WW, Liu CY. Mastermind-like transcriptional co-activator-mediated Notch signaling is indispensable for maintaining conjunctival epithelial identity. Development (Cambridge, England). 140: 594-605. PMID 23293291 DOI: 10.1242/Dev.082842 |
0.457 |
|
| 2013 |
Chiang MY, Shestova O, Xu L, Aster JC, Pear WS. Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells. Blood. 121: 905-17. PMID 23115273 DOI: 10.1182/Blood-2012-03-416503 |
0.543 |
|
| 2013 |
Dail M, Wong J, Lawrence J, O'Connor D, Nakitandwe J, Chen S, Akagi K, Lee L, Aster JC, Pear WS, Sampath D, Downing JR, Shannon K. Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones Blood. 122: 2677-2677. DOI: 10.1182/Blood.V122.21.2677.2677 |
0.483 |
|
| 2012 |
Fragoso R, Mao T, Wang S, Schaffert S, Gong X, Yue S, Luong R, Min H, Yashiro-Ohtani Y, Davis M, Pear W, Chen CZ. Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1/b-1. Plos Genetics. 8: e1002855. PMID 22916024 DOI: 10.1371/Journal.Pgen.1002855 |
0.343 |
|
| 2012 |
Bailis W, Pear WS. Notch and PI3K: how is the road traveled? Blood. 120: 1349-50. PMID 22899471 DOI: 10.1182/Blood-2012-06-435099 |
0.398 |
|
| 2012 |
Pan X, Jones M, Jiang J, Zaprazna K, Yu D, Pear W, Maillard I, Atchison ML. Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells. Plos One. 7: e30656. PMID 22292011 DOI: 10.1371/Journal.Pone.0030656 |
0.47 |
|
| 2012 |
Wang H, Zang C, Taing L, Wong H, Yashiro-Ohtani Y, Blacklow S, Pear WS, Liu XS, Aster JC. Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements Blood. 120: 1277-1277. DOI: 10.1182/Blood.V120.21.1277.1277 |
0.452 |
|
| 2012 |
Liu H, Yashiro-Ohtani Y, Chi AWS, Pear WS. Abstract 3075: NOTCH1 dimerization directly activates Rag1 and Rag2 in murine T-cell leukemia Cancer Research. 72: 3075-3075. DOI: 10.1158/1538-7445.Am2012-3075 |
0.479 |
|
| 2011 |
Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. Plos One. 6: e25645. PMID 22022427 DOI: 10.1371/Journal.Pone.0025645 |
0.537 |
|
| 2011 |
Liu H, Chiang MY, Pear WS. Critical roles of NOTCH1 in acute T-cell lymphoblastic leukemia. International Journal of Hematology. 94: 118-25. PMID 21814881 DOI: 10.1007/S12185-011-0899-3 |
0.553 |
|
| 2011 |
Chi AW, Chavez A, Xu L, Weber BN, Shestova O, Schaffer A, Wertheim G, Pear WS, Izon D, Bhandoola A. Identification of Flt3⁺CD150⁻ myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential. Blood. 118: 2723-32. PMID 21791413 DOI: 10.1182/Blood-2010-09-309989 |
0.606 |
|
| 2011 |
Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 14908-13. PMID 21737748 DOI: 10.1073/Pnas.1109023108 |
0.379 |
|
| 2011 |
Pajcini KV, Speck NA, Pear WS. Notch signaling in mammalian hematopoietic stem cells Leukemia. 25: 1525-1532. PMID 21647159 DOI: 10.1038/Leu.2011.127 |
0.493 |
|
| 2011 |
Komine O, Nagaoka M, Hiraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K. RBP-J promotes the maturation of neuronal progenitors. Developmental Biology. 354: 44-54. PMID 21443869 DOI: 10.1016/J.Ydbio.2011.03.020 |
0.409 |
|
| 2011 |
Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. The Journal of Pathology. 223: 262-73. PMID 20967796 DOI: 10.1002/Path.2789 |
0.518 |
|
| 2011 |
Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. Blood. 117: 299-308. PMID 20870902 DOI: 10.1182/Blood-2010-03-271940 |
0.521 |
|
| 2011 |
Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Perrimon N, Kung AL, Pear WS, Blacklow SC, Aster JC, Stegmaier K. Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies Blood. 118: 555-555. DOI: 10.1182/Blood.V118.21.555.555 |
0.516 |
|
| 2011 |
Natsuizaka M, Ohashi S, Naganuma S, Kalman RA, Ohyama A, Rhoades B, Vega ME, Stairs DB, Klein-Szanto AJ, Diehl JA, Basu D, Herlyn M, Pear WS, Nakagawa H. Abstract 5194: Notch regulates squamous differentiation, cell plasticity and tumor heterogeneity in esophageal carcinoma Cancer Research. 71: 5194-5194. DOI: 10.1158/1538-7445.Am2011-5194 |
0.48 |
|
| 2010 |
Pear WS. Hooked on Hes: a T-ALL of addiction. Immunity. 33: 645-7. PMID 21094458 DOI: 10.1016/J.Immuni.2010.11.018 |
0.46 |
|
| 2010 |
Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes & Development. 24: 2395-407. PMID 20935071 DOI: 10.1101/Gad.1975210 |
0.506 |
|
| 2010 |
Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 116: 5455-64. PMID 20852131 DOI: 10.1182/Blood-2010-05-286328 |
0.461 |
|
| 2010 |
Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 116: 4948-57. PMID 20805362 DOI: 10.1182/Blood-2009-10-247361 |
0.336 |
|
| 2010 |
Ohashi S, Natsuizaka M, Yashiro-Ohtani Y, Kalman RA, Nakagawa M, Wu L, Klein-Szanto AJ, Herlyn M, Diehl JA, Katz JP, Pear WS, Seykora JT, Nakagawa H. NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network. Gastroenterology. 139: 2113-23. PMID 20801121 DOI: 10.1053/J.Gastro.2010.08.040 |
0.468 |
|
| 2010 |
Yashiro-Ohtani Y, Ohtani T, Pear WS. Notch regulation of early thymocyte development. Seminars in Immunology. 22: 261-9. PMID 20630772 DOI: 10.1016/J.Smim.2010.04.015 |
0.55 |
|
| 2010 |
Liu X, Karnell JL, Yin B, Zhang R, Zhang J, Li P, Choi Y, Maltzman JS, Pear WS, Bassing CH, Turka LA. Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice. The Journal of Clinical Investigation. 120: 2497-507. PMID 20516645 DOI: 10.1172/Jci42382 |
0.513 |
|
| 2010 |
Khwaja SS, Liu H, Tong C, Jin F, Pear WS, van Deursen J, Bram RJ. HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. The Journal of Clinical Investigation. 120: 2537-48. PMID 20516639 DOI: 10.1172/Jci41277 |
0.496 |
|
| 2010 |
Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 116: 1321-8. PMID 20410507 DOI: 10.1182/Blood-2009-07-229450 |
0.392 |
|
| 2010 |
Pear WS. New roles for Notch in tuberous sclerosis. The Journal of Clinical Investigation. 120: 84-7. PMID 20038806 DOI: 10.1172/Jci41897 |
0.385 |
|
| 2010 |
Fragoso AR, Mao T, Wang S, Schaffert S, Min H, Pear WS, Chen C. Essential Role for Mir-181a1/b1 In T-Cell Acute Lymphoblastic Leukemia Blood. 116: 470-470. DOI: 10.1182/Blood.V116.21.470.470 |
0.437 |
|
| 2010 |
Liu H, Chi A, Arnett K, Chiang M, Xu L, Shestova O, Wang H, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Critical Functions for Notch Dimerization In T Cell Transformation. Blood. 116: 3647-3647. DOI: 10.1182/Blood.V116.21.3647.3647 |
0.516 |
|
| 2010 |
Ohashi S, Natsuizaka M, Kalman RA, Yang Y, Stairs D, Katz JP, Pear WS, Klein-Szanto AJ, Nakagawa H. 185 NOTCH3 Activation at the Onset of Esophageal Squamous Epithelial Differentiation Gastroenterology. 138: S-34. DOI: 10.1016/S0016-5085(10)60156-4 |
0.338 |
|
| 2010 |
Nakagawa M, Ohashi S, Natsuizaka M, Vega ME, Stairs D, Klein-Szanto AJ, Diehl JA, Pear WS, Nakagawa H, Rustgi AK. 184 Cyclin D1 and EGFR Promote Invasive Growth of Human Esophageal Epithelial Cells in Concert With Impaired Notch Signaling Gastroenterology. 138: S-34. DOI: 10.1016/S0016-5085(10)60155-2 |
0.383 |
|
| 2010 |
Arnett KL, McArthur D, Pear W, Aster J, Blacklow S. Structure and Mechanism of Notch Transcription Complex Dimerization in Gene Regulation Biophysical Journal. 98: 662a. DOI: 10.1016/J.Bpj.2009.12.3634 |
0.379 |
|
| 2009 |
Zhao L, Li W, Marshall C, Griffin T, Hanson M, Hick R, Dentchev T, Williams E, Werth A, Miller C, Bashir H, Pear W, Seykora JT. Srcasm inhibits Fyn-induced cutaneous carcinogenesis with modulation of Notch1 and p53. Cancer Research. 69: 9439-47. PMID 19934324 DOI: 10.1158/0008-5472.Can-09-2976 |
0.357 |
|
| 2009 |
Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Development. 23: 1665-76. PMID 19605688 DOI: 10.1101/Gad.1793709 |
0.726 |
|
| 2009 |
Pinnix CC, Lee JT, Liu ZJ, McDaid R, Balint K, Beverly LJ, Brafford PA, Xiao M, Himes B, Zabierowski SE, Yashiro-Ohtani Y, Nathanson KL, Bengston A, Pollock PM, Weeraratna AT, ... ... Pear WS, et al. Active Notch1 confers a transformed phenotype to primary human melanocytes. Cancer Research. 69: 5312-20. PMID 19549918 DOI: 10.1158/0008-5472.Can-08-3767 |
0.392 |
|
| 2009 |
High FA, Jain R, Stoller JZ, Antonucci NB, Lu MM, Loomes KM, Kaestner KH, Pear WS, Epstein JA. Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development. The Journal of Clinical Investigation. 119: 1986-96. PMID 19509466 DOI: 10.1172/Jci38922 |
0.35 |
|
| 2009 |
Maillard I, Chen YX, Friedman A, Yang Y, Tubbs AT, Shestova O, Pear WS, Hua X. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood. 113: 1661-9. PMID 19228930 DOI: 10.1182/Blood-2008-01-135012 |
0.418 |
|
| 2009 |
Chiang MY, Childs ME, Romany C, Shestova O, Aster J, Pear WS. C-Myc, but Not Akt, Can Substitute for Notch in Lymphomagenesis. Blood. 114: 7-7. DOI: 10.1182/Blood.V114.22.7.7 |
0.516 |
|
| 2009 |
Chiang MY, Shestova O, Childs ME, Romany C, Aster J, Pear WS. Divergent Effects of Notch Signaling On Leukemia Stem Cells and Hematopoietic Stem Cells. Blood. 114: 395-395. DOI: 10.1182/Blood.V114.22.395.395 |
0.542 |
|
| 2009 |
Ohashi S, Nakagawa M, Natsuizaka M, Stairs DB, Grugan KD, Kalabis J, Wong G, Yang Y, Klein-Szanto AJ, Herlyn M, Pear WS, Katz JP, Nakagawa H. 540 Epithelial Reconstitution Reveals Regulation of Differentiation and Cell Fate Decisions Through a Novel Interplay Between the Notch Signaling and Essential Cancer Genes in Esophageal Carcinogenesis Gastroenterology. 136: A-83. DOI: 10.1016/S0016-5085(09)60375-9 |
0.438 |
|
| 2009 |
Ohashi S, Kalman RA, Natsuizaka M, Grugan KD, Stairs DB, Kalabis J, Andl C, Yang Y, Rhoades B, Pear WS, Katz JP, Nakagawa H. 278 Genetic Ablation of the Notch Signaling Promotes TGF-β-Induced Epithelial-Mesenchymal Transition Involving Posttranscriptional Regulation of ZEB1 and ZEB2 By MicroRNA-200 Family Members Gastroenterology. 136: A-54. DOI: 10.1016/S0016-5085(09)60243-2 |
0.326 |
|
| 2008 |
Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell. 3: 314-26. PMID 18786418 DOI: 10.1016/J.Stem.2008.07.010 |
0.558 |
|
| 2008 |
Chiang MY, Xu L, Shestova O, Histen G, L'heureux S, Romany C, Childs ME, Gimotty PA, Aster JC, Pear WS. Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia. The Journal of Clinical Investigation. 118: 3181-94. PMID 18677410 DOI: 10.1172/Jci35090 |
0.513 |
|
| 2008 |
Dedhia P, Kambayashi T, Pear WS. Notch2 paves the way to mast cells by Hes1 and Gata3. Proceedings of the National Academy of Sciences of the United States of America. 105: 7629-30. PMID 18515423 DOI: 10.1073/Pnas.0803439105 |
0.373 |
|
| 2008 |
Maillard I, Koch U, Dumortier A, Shestova O, Xu L, Sai H, Pross SE, Aster JC, Bhandoola A, Radtke F, Pear WS. Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell. 2: 356-66. PMID 18397755 DOI: 10.1182/Blood.V106.11.267.267 |
0.496 |
|
| 2008 |
Cepko C, Pear W. Retrovirus infection of cells in vitro and in vivo. Current Protocols in Molecular Biology. Unit9.14. PMID 18265282 DOI: 10.1002/0471142727.Mb0914S36 |
0.372 |
|
| 2008 |
Pear W. Transient transfection methods for preparation of high-titer retroviral supernatants. Current Protocols in Molecular Biology. Unit9.11. PMID 18265279 DOI: 10.1002/0471142727.Mb0911S36 |
0.343 |
|
| 2008 |
High FA, Lu MM, Pear WS, Loomes KM, Kaestner KH, Epstein JA. Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proceedings of the National Academy of Sciences of the United States of America. 105: 1955-9. PMID 18245384 DOI: 10.1073/Pnas.0709663105 |
0.32 |
|
| 2008 |
Aster JC, Pear WS, Blacklow SC. Notch signaling in leukemia. Annual Review of Pathology. 3: 587-613. PMID 18039126 DOI: 10.1097/00062752-200107000-00010 |
0.443 |
|
| 2008 |
Keeshan K, Shestova O, Ussin L, Pear WS. Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules & Diseases. 40: 119-21. PMID 17988908 DOI: 10.1016/J.Bcmd.2007.06.005 |
0.369 |
|
| 2008 |
Pear WS. Notch and Leukemia: Lessons from Mouse Models. Blood. 112: sci-31-sci-31. DOI: 10.1182/Blood.V112.11.Sci-31.Sci-31 |
0.504 |
|
| 2008 |
Dedhia P, Keeshan K, Vega M, Uljon S, Xu L, Shestova O, Romany C, Blacklow SC, Pear WS. Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia Blood. 112: 2950-2950. DOI: 10.1182/Blood.V112.11.2950.2950 |
0.368 |
|
| 2008 |
Cornejo MG, Mercher T, Growney JD, Jesneck J, Maillard I, Pear WS, Aster J, Gilliland DG. Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells Blood. 112: 1370-1370. DOI: 10.1182/Blood.V112.11.1370.1370 |
0.546 |
|
| 2008 |
Yang Y, Stairs DB, Michaylira CZ, Lee JJ, Kalabis J, Grugan KD, Andl CD, Budo D, Pear WS, Katz JP, Rustgi AK, Nakagawa H. M2010 Notch Signaling Regulates Esophageal Epithelial Homeostasis and Tumor Progression Gastroenterology. 134: A-450. DOI: 10.1016/S0016-5085(08)62103-4 |
0.347 |
|
| 2007 |
Proweller A, Wright AC, Horng D, Cheng L, Lu MM, Lepore JJ, Pear WS, Parmacek MS. Notch signaling in vascular smooth muscle cells is required to pattern the cerebral vasculature. Proceedings of the National Academy of Sciences of the United States of America. 104: 16275-80. PMID 17909179 DOI: 10.1073/Pnas.0707950104 |
0.31 |
|
| 2007 |
Santos MA, Sarmento LM, Rebelo M, Doce AA, Maillard I, Dumortier A, Neves H, Radtke F, Pear WS, Parreira L, Demengeot J. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 15454-9. PMID 17878313 DOI: 10.1073/Pnas.0702891104 |
0.483 |
|
| 2007 |
Wu L, Maillard I, Nakamura M, Pear WS, Griffin JD. The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development. Blood. 110: 3618-23. PMID 17699740 DOI: 10.1182/Blood-2007-06-097030 |
0.563 |
|
| 2007 |
Wouters BJ, Jordà MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, Langerak AW, He Y, Yashiro-Ohtani Y, Zhang P, Hetherington CJ, Verhaak RG, Valk PJ, Löwenberg B, Tenen DG, ... Pear WS, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood. 110: 3706-14. PMID 17671232 DOI: 10.1182/Blood-2007-02-073486 |
0.477 |
|
| 2007 |
Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 27: 100-10. PMID 17658278 DOI: 10.1016/J.Immuni.2007.04.018 |
0.732 |
|
| 2007 |
Spaulding C, Reschly EJ, Zagort DE, Yashiro-Ohtani Y, Beverly LJ, Capobianco A, Pear WS, Kee BL. Notch1 co-opts lymphoid enhancer factor 1 for survival of murine T-cell lymphomas. Blood. 110: 2650-8. PMID 17585052 DOI: 10.1182/Blood-2007-04-084202 |
0.542 |
|
| 2007 |
Maillard I, Pear WS. Immunology. Keeping a tight leash on Notch. Science (New York, N.Y.). 316: 840-2. PMID 17495159 DOI: 10.1126/Science.1143336 |
0.527 |
|
| 2007 |
Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proceedings of the National Academy of Sciences of the United States of America. 104: 2103-8. PMID 17284587 DOI: 10.1073/Pnas.0611092104 |
0.384 |
|
| 2007 |
High FA, Zhang M, Proweller A, Tu L, Parmacek MS, Pear WS, Epstein JA. An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. The Journal of Clinical Investigation. 117: 353-63. PMID 17273555 DOI: 10.1172/Jci30070 |
0.423 |
|
| 2007 |
Thomas M, Calamito M, Srivastava B, Maillard I, Pear WS, Allman D. Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation. Blood. 109: 3342-50. PMID 17179224 DOI: 10.1182/Blood-2006-09-046698 |
0.458 |
|
| 2007 |
Roy M, Pear WS, Aster JC. The multifaceted role of Notch in cancer. Current Opinion in Genetics & Development. 17: 52-9. PMID 17178457 DOI: 10.1016/J.Gde.2006.12.001 |
0.515 |
|
| 2007 |
Talebian L, Li Z, Guo Y, Gaudet J, Speck ME, Sugiyama D, Kaur P, Pear WS, Maillard I, Speck NA. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood. 109: 11-21. PMID 16940420 DOI: 10.1182/Blood-2006-05-021188 |
0.445 |
|
| 2007 |
Maillard I, Chen Y, Tubbs AT, Shestova O, Pear WS, Hua X. Menin Regulates the Function of Lymphoid Progenitors and Hematopoietic Stem Cells. Blood. 110: 1257-1257. DOI: 10.1182/Blood.V110.11.1257.1257 |
0.436 |
|
| 2006 |
Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Tobias JW, Valk P, Carroll M, Aster JC, Delwel R, Pear WS. Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell. 10: 401-11. PMID 17097562 DOI: 10.1016/J.Ccr.2006.09.012 |
0.439 |
|
| 2006 |
Maillard I, Tu L, Sambandam A, Yashiro-Ohtani Y, Millholland J, Keeshan K, Shestova O, Xu L, Bhandoola A, Pear WS. The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. The Journal of Experimental Medicine. 203: 2239-45. PMID 16966428 DOI: 10.1084/Jem.20061020 |
0.489 |
|
| 2006 |
Proweller A, Tu L, Lepore JJ, Cheng L, Lu MM, Seykora J, Millar SE, Pear WS, Parmacek MS. Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Research. 66: 7438-44. PMID 16885339 DOI: 10.1158/0008-5472.Can-06-0793 |
0.437 |
|
| 2006 |
Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Molecular and Cellular Biology. 26: 6261-71. PMID 16880534 DOI: 10.1128/Mcb.02478-05 |
0.46 |
|
| 2006 |
Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, ... Pear WS, et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes & Development. 20: 2096-109. PMID 16847353 DOI: 10.1101/Gad.1450406 |
0.496 |
|
| 2006 |
Reschly EJ, Spaulding C, Vilimas T, Graham WV, Brumbaugh RL, Aifantis I, Pear WS, Kee BL. Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms. Blood. 107: 4115-21. PMID 16449526 DOI: 10.1182/Blood-2005-09-3551 |
0.529 |
|
| 2006 |
Chen YX, Yan J, Keeshan K, Tubbs AT, Wang H, Silva A, Brown EJ, Hess JL, Pear WS, Hua X. The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America. 103: 1018-23. PMID 16415155 DOI: 10.1073/Pnas.0510347103 |
0.396 |
|
| 2006 |
Maillard I, Schwarz BA, Sambandam A, Fang T, Shestova O, Xu L, Bhandoola A, Pear WS. Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood. 107: 3511-9. PMID 16397133 DOI: 10.1182/Blood-2005-08-3454 |
0.675 |
|
| 2006 |
Wu L, Maillard I, Nakamura M, Pear WS, Griffin JD. The MAML1 Transcriptional Co-Activator Is Required for the Development of Marginal Zone B Cells. Blood. 108: 777-777. DOI: 10.1182/Blood.V108.11.777.777 |
0.55 |
|
| 2006 |
Keeshan K, He Y, Wouters BJ, Shestova O, Xu L, Sai H, Rodriguez CG, Maillard I, Valk P, Carroll M, Aster JC, Delwel R, Pear WS. Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia. Blood. 108: 776-776. DOI: 10.1182/Blood.V108.11.776.776 |
0.398 |
|
| 2006 |
Chiang MY, Shestova O, Histin G, Xu M, Pear WS, Aster JC. Sporadic Notch1 Mutations Found in Human T-ALL Drive T Cell Development but Not Leukemogenesis in Murine Models: Implications for Pathogenesis and gamma-Secretase Inhibitor (GSI) Therapy. Blood. 108: 707-707. DOI: 10.1182/Blood.V108.11.707.707 |
0.48 |
|
| 2006 |
Maillard I, High F, Shestova O, Dedhia P, Epstein JA, Pear WS. Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver through a Non-Cell-Autonomous Mechanism. Blood. 108: 440-440. DOI: 10.1182/Blood.V108.11.440.440 |
0.494 |
|
| 2006 |
Wouters BJ, Louwers I, Erpelinck-Verschueren CA, Valk PJ, Tielemans D, Langerak AW, Tenen DG, Pear WS, Lowenberg B, Delwel R. Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations. Blood. 108: 2237-2237. DOI: 10.1182/Blood.V108.11.2237.2237 |
0.416 |
|
| 2005 |
Pear WS, Simon MC. Lasting longer without oxygen: The influence of hypoxia on Notch signaling. Cancer Cell. 8: 435-7. PMID 16338655 DOI: 10.1016/J.Ccr.2005.11.016 |
0.443 |
|
| 2005 |
Radtke F, Schweisguth F, Pear W. The Notch 'gospel'. Embo Reports. 6: 1120-5. PMID 16299468 DOI: 10.1038/Sj.Embor.7400585 |
0.435 |
|
| 2005 |
Tu L, Fang TC, Artis D, Shestova O, Pross SE, Maillard I, Pear WS. Notch signaling is an important regulator of type 2 immunity. The Journal of Experimental Medicine. 202: 1037-42. PMID 16230473 DOI: 10.1084/Jem.20050923 |
0.721 |
|
| 2005 |
Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC, Aster JC, Allman D, Pear WS. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood. 106: 3898-906. PMID 16118316 DOI: 10.1182/Blood-2005-01-0355 |
0.487 |
|
| 2005 |
Sambandam A, Maillard I, Zediak VP, Xu L, Gerstein RM, Aster JC, Pear WS, Bhandoola A. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nature Immunology. 6: 663-70. PMID 15951813 DOI: 10.1038/Ni1216 |
0.5 |
|
| 2005 |
Maillard I, Fang T, Pear WS. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annual Review of Immunology. 23: 945-74. PMID 15771590 DOI: 10.1146/Annurev.Immunol.23.021704.115747 |
0.72 |
|
| 2005 |
Chiang MY, Pear WS. Cancer genetics: activated notch takes center stage in T-cell leukemogenesis. European Journal of Human Genetics : Ejhg. 13: 393-5. PMID 15702128 DOI: 10.1038/Sj.Ejhg.5201380 |
0.435 |
|
| 2005 |
Proweller A, Pear WS, Parmacek MS. Notch signaling represses myocardin-induced smooth muscle cell differentiation. The Journal of Biological Chemistry. 280: 8994-9004. PMID 15634680 DOI: 10.1074/Jbc.M413316200 |
0.449 |
|
| 2005 |
Xu ML, Chiang M, Lee W, Pear WS, Aster JC. Identification of a C-Terminal Negative Regulatory Sequence in NOTCH1 That Influences Signal Strength and Leukemogenic Activity. Blood. 106: 535-535. DOI: 10.1182/Blood.V106.11.535.535 |
0.457 |
|
| 2005 |
Guo Y, Talebian L, Maillard I, Speck CL, Pear WS, Rothenberg EV, Speck NA. Reduction of Core Binding Factor beta (CBFβ) Dosage Blocks T Cell Development. Blood. 106: 2714-2714. DOI: 10.1182/Blood.V106.11.2714.2714 |
0.536 |
|
| 2005 |
Zweidler-McKay PA, Lum JJ, Thompson CB, Pear WS. A Critical Role for the Bcl-2 Pathway in Notch-Mediated B Cell Apoptosis, Where Growth Arrest Is Independent of the E2A, IL-3 and p21Waf1/p27Kip1 Pathways. Blood. 106: 237-237. DOI: 10.1182/Blood.V106.11.237.237 |
0.438 |
|
| 2005 |
Maillard I, Talebian L, Li Z, Guo Y, Sugiyama D, Speck ME, Pear WS, Speck NA. A Hypomorphic Cbfb Allele Reveals a Critical Dosage-Sensitive Function of Core Binding Factors at the Earliest Stages of T Cell Development. Blood. 106: 124-124. DOI: 10.1182/Blood.V106.11.124.124 |
0.504 |
|
| 2005 |
Chiang MY, Hong S, Shestova O, Lee W, Xu M, Pear WS, Aster JC. Synergistic Induction of T Cell Acute Lymphoblastic Leukemia by Functionally Distinct Mutations in NOTCH1. Blood. 106: 1200-1200. DOI: 10.1182/Blood.V106.11.1200.1200 |
0.46 |
|
| 2005 |
Pear WS. Cooking up T cells Blood. 105: 1373-1374. DOI: 10.1182/Blood-2004-12-4629 |
0.409 |
|
| 2005 |
Sambandam A, Maillard I, Zediak VP, Xu L, Gerstein RM, Aster JC, Pear WS, Bhandoola A. Erratum: Notch signaling controls the generation and differentiation of early T lineage progenitors Nature Immunology. 6: 852-852. DOI: 10.1038/Ni0805-852A |
0.455 |
|
| 2004 |
Pear WS, Aster JC. T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling. Current Opinion in Hematology. 11: 426-33. PMID 15548998 DOI: 10.1097/01.Moh.0000143965.90813.70 |
0.514 |
|
| 2004 |
Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Molecular and Cellular Biology. 24: 9265-73. PMID 15485896 DOI: 10.1128/Mcb.24.21.9265-9273.2004 |
0.327 |
|
| 2004 |
Zweidler-McKay PA, Pear WS. Notch and T cell malignancy. Seminars in Cancer Biology. 14: 329-40. PMID 15288258 DOI: 10.1016/J.Semcancer.2004.04.012 |
0.559 |
|
| 2004 |
Maillard I, Weng AP, Carpenter AC, Rodriguez CG, Sai H, Xu L, Allman D, Aster JC, Pear WS. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood. 104: 1696-702. PMID 15187027 DOI: 10.1182/Blood-2004-02-0514 |
0.561 |
|
| 2004 |
Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. Notch 1 signaling regulates peripheral T cell activation. Immunity. 20: 407-15. PMID 15084270 DOI: 10.1016/S1074-7613(04)00081-0 |
0.56 |
|
| 2004 |
Feng B, Cheng S, Pear WS, Liou HC. NF-kB inhibitor blocks B cell development at two checkpoints. Medical Immunology (London, England). 3: 1. PMID 15050028 DOI: 10.1186/1476-9433-3-1 |
0.426 |
|
| 2004 |
Pear WS, Tu L, Stein PL. Lineage choices in the developing thymus: choosing the T and NKT pathways. Current Opinion in Immunology. 16: 167-73. PMID 15023409 DOI: 10.1016/J.Coi.2004.01.011 |
0.48 |
|
| 2004 |
Matte CC, Cormier J, Anderson BE, Athanasiadis I, Liu J, Emerson SG, Pear W, Shlomchik WD. Graft-versus-leukemia in a retrovirally induced murine CML model: mechanisms of T-cell killing. Blood. 103: 4353-61. PMID 14982874 DOI: 10.1182/Blood-2003-10-3735 |
0.435 |
|
| 2004 |
Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research. 55: 581-4. PMID 14739366 DOI: 10.1203/01.Pdr.0000113462.98851.2E |
0.313 |
|
| 2004 |
Pross S, Millholland JM, Sai H, Weng AP, Aster JC, Pear WS, Maillard I. Efficient Inhibition of Notch3 and Notch4 Family Members In Vivo by a Dominant Negative Mutant of Mastermind. Blood. 104: 1617-1617. DOI: 10.1182/Blood.V104.11.1617.1617 |
0.578 |
|
| 2004 |
Maillard I, Sambandan A, Zediak VP, Schwarz B, Xu L, Aster JC, Pear WS, Bhandoola A. Intrathymic and Extrathymic Notch-Dependent T Lineage Checkpoints during Normal Development and after Bone Marrow Transplantation. Blood. 104: 1190-1190. DOI: 10.1182/Blood.V104.11.1190.1190 |
0.555 |
|
| 2003 |
Maillard I, Adler SH, Pear WS. Notch and the immune system. Immunity. 19: 781-91. PMID 14670296 DOI: 10.1016/S1074-7613(03)00325-X |
0.538 |
|
| 2003 |
Adler SH, Chiffoleau E, Xu L, Dalton NM, Burg JM, Wells AD, Wolfe MS, Turka LA, Pear WS. Notch signaling augments T cell responsiveness by enhancing CD25 expression. Journal of Immunology (Baltimore, Md. : 1950). 171: 2896-903. PMID 12960312 DOI: 10.4049/Jimmunol.171.6.2896 |
0.508 |
|
| 2003 |
Wertheim JA, Perera SA, Hammer DA, Ren R, Boettiger D, Pear WS. Localization of BCR-ABL to F-actin regulates cell adhesion but does not attenuate CML development. Blood. 102: 2220-8. PMID 12791659 DOI: 10.1182/Blood-2003-01-0062 |
0.681 |
|
| 2003 |
Maillard I, He Y, Pear WS. From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. Immunity. 18: 587-9. PMID 12753735 DOI: 10.1016/S1074-7613(03)00119-5 |
0.513 |
|
| 2003 |
Pear WS, Radtke F. Notch signaling in lymphopoiesis. Seminars in Immunology. 15: 69-79. PMID 12681943 DOI: 10.1016/S1044-5323(03)00003-4 |
0.534 |
|
| 2003 |
Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell. 3: 203-5. PMID 12676578 DOI: 10.1016/S1535-6108(03)00052-7 |
0.374 |
|
| 2003 |
He Y, Pear WS. Notch signalling in B cells. Seminars in Cell & Developmental Biology. 14: 135-42. PMID 12651097 DOI: 10.1016/S1084-9521(02)00182-9 |
0.509 |
|
| 2003 |
Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Molecular and Cellular Biology. 23: 655-64. PMID 12509463 DOI: 10.1128/Mcb.23.2.655-664.2003 |
0.521 |
|
| 2002 |
Allenspach EJ, Maillard I, Aster JC, Pear WS. Notch signaling in cancer. Cancer Biology & Therapy. 1: 466-76. PMID 12496471 DOI: 10.4161/Cbt.1.5.159 |
0.481 |
|
| 2002 |
Wertheim JA, Miller JP, Xu L, He Y, Pear WS. The biology of chronic myelogenous leukemia:mouse models and cell adhesion. Oncogene. 21: 8612-28. PMID 12476308 DOI: 10.1038/Sj.Onc.1206089 |
0.716 |
|
| 2002 |
Allman D, Aster JC, Pear WS. Notch signaling in hematopoiesis and early lymphocyte development. Immunological Reviews. 187: 75-86. PMID 12366684 DOI: 10.1034/J.1600-065X.2002.18707.X |
0.499 |
|
| 2002 |
Wertheim JA, Forsythe K, Druker BJ, Hammer D, Boettiger D, Pear WS. BCR-ABL-induced adhesion defects are tyrosine kinase-independent. Blood. 99: 4122-30. PMID 12010816 DOI: 10.1182/Blood.V99.11.4122 |
0.708 |
|
| 2002 |
Allman D, Punt JA, Izon DJ, Aster JC, Pear WS. An invitation to T and more: notch signaling in lymphopoiesis. Cell. 109: S1-11. PMID 11983148 DOI: 10.1016/S0092-8674(02)00689-X |
0.501 |
|
| 2002 |
He Y, Wertheim JA, Xu L, Miller JP, Karnell FG, Choi JK, Ren R, Pear WS. The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. Blood. 99: 2957-68. PMID 11929787 DOI: 10.1182/Blood.V99.8.2957 |
0.699 |
|
| 2002 |
Judd BA, Myung PS, Obergfell A, Myers EE, Cheng AM, Watson SP, Pear WS, Allman D, Shattil SJ, Koretzky GA. Differential requirement for LAT and SLP-76 in GPVI versus T cell receptor signaling. The Journal of Experimental Medicine. 195: 705-17. PMID 11901197 DOI: 10.1084/Jem.20011583 |
0.459 |
|
| 2002 |
Izon DJ, Punt JA, Pear WS. Deciphering the role of Notch signaling in lymphopoiesis. Current Opinion in Immunology. 14: 192-9. PMID 11869892 DOI: 10.1016/S0952-7915(02)00321-7 |
0.551 |
|
| 2002 |
Izon DJ, Aster JC, He Y, Weng A, Karnell FG, Patriub V, Xu L, Bakkour S, Rodriguez C, Allman D, Pear WS. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity. 16: 231-43. PMID 11869684 DOI: 10.1016/S1074-7613(02)00271-6 |
0.563 |
|
| 2001 |
Bannish G, Fuentes-Pananá EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis Journal of Experimental Medicine. 194: 1583-1596. PMID 11733573 DOI: 10.1084/Jem.194.11.1583 |
0.447 |
|
| 2001 |
Di Cristofano A, Niki M, Zhao M, Karnell FG, Clarkson B, Pear WS, Van Aelst L, Pandolfi PP. p62(dok), a negative regulator of Ras and mitogen-activated protein kinase (MAPK) activity, opposes leukemogenesis by p210(bcr-abl). The Journal of Experimental Medicine. 194: 275-84. PMID 11489947 DOI: 10.1084/Jem.194.3.275 |
0.356 |
|
| 2001 |
Izon D, Rudd K, DeMuth W, Pear WS, Clendenin C, Lindsley RC, Allman D. A common pathway for dendritic cell and early B cell development. Journal of Immunology (Baltimore, Md. : 1950). 167: 1387-92. PMID 11466357 DOI: 10.4049/Jimmunol.167.3.1387 |
0.403 |
|
| 2001 |
Allman D, Karnell FG, Punt JA, Bakkour S, Xu L, Myung P, Koretzky GA, Pui JC, Aster JC, Pear WS. Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells Journal of Experimental Medicine. 194: 99-106. PMID 11435476 DOI: 10.1084/Jem.194.1.99 |
0.55 |
|
| 2001 |
Izon DJ, Punt JA, Xu L, Karnell FG, Allman D, Myung PS, Boerth NJ, Pui JC, Koretzky GA, Pear WS. Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength. Immunity. 14: 253-64. PMID 11290335 DOI: 10.1016/S1074-7613(01)00107-8 |
0.44 |
|
| 2001 |
Zhang X, Wong R, Hao SX, Pear WS, Ren R. The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. Blood. 97: 277-87. PMID 11133772 DOI: 10.1182/Blood.V97.1.277 |
0.438 |
|
| 2000 |
Varnum-Finney B, Xu L, Brashem-Stein C, Nourigat C, Flowers D, Bakkour S, Pear WS, Bernstein ID. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nature Medicine. 6: 1278-81. PMID 11062542 DOI: 10.1038/81390 |
0.501 |
|
| 2000 |
Judd BA, Myung PS, Leng L, Obergfell A, Pear WS, Shattil SJ, Koretzky GA. Hematopoietic reconstitution of SLP-76 corrects hemostasis and platelet signaling through alpha IIb beta 3 and collagen receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 12056-61. PMID 11050236 DOI: 10.1073/Pnas.97.22.12056 |
0.347 |
|
| 2000 |
Aster JC, Xu L, Karnell FG, Patriub V, Pui JC, Pear WS. Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by Notch1 Molecular and Cellular Biology. 20: 7505-7515. PMID 11003647 DOI: 10.1128/Mcb.20.20.7505-7515.2000 |
0.518 |
|
| 2000 |
Pear WS. Signaling in leukemia: Which messenger to kill? Journal of Clinical Investigation. 105: 419-422. PMID 10683370 DOI: 10.1172/Jci9461 |
0.455 |
|
| 2000 |
Quackenbush RC, Reuther GW, Miller JP, Courtney KD, Pear WS, Pendergast AM. Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases Blood. 95: 2913-2921. DOI: 10.1182/Blood.V95.9.2913.009K32_2913_2921 |
0.394 |
|
| 1999 |
Pui JC, Allman D, Xu L, DeRocco S, Karnell FG, Bakkour S, Lee JY, Kadesch T, Hardy RR, Aster JC, Pear WS. Notch1 expression in early lymphopoiesis influences B versus T lineage determination Immunity. 11: 299-308. PMID 10514008 DOI: 10.1016/S1074-7613(00)80105-3 |
0.545 |
|
| 1999 |
Jehn BM, Bielke W, Pear WS, Osborne BA. Cutting edge: Protective effects of Notch-1 on TCR-induced apoptosis Journal of Immunology. 162: 635-638. PMID 9916679 |
0.396 |
|
| 1998 |
Pear WS, Miller JP, Xu L, Pui JC, Soffer B, Quackenbush RC, Pendergast AM, Bronson R, Aster JC, Scott ML, Baltimore D. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 92: 3780-92. PMID 9808572 DOI: 10.1182/Blood.V92.10.3780.422K15_3780_3792 |
0.347 |
|
| 1997 |
Salgia R, Li JL, Ewaniuk DS, Pear W, Pisick E, Burky SA, Ernst T, Sattler M, Chen LB, Griffin JD. BCR/ABL induces multiple abnormalities of cytoskeletal function. The Journal of Clinical Investigation. 100: 46-57. PMID 9202056 DOI: 10.1172/Jci119520 |
0.446 |
|
| 1996 |
Pear WS, Aster JC, Scott ML, Hasserjian RP, Soffer B, Sklar J, Baltimore D. Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles Journal of Experimental Medicine. 183: 2283-2291. PMID 8642337 DOI: 10.1084/Jem.183.5.2283 |
0.499 |
|
| 1995 |
Gurish MF, Pear WS, Stevens RL, Scott ML, Sokol K, Ghildyal N, Webster MJ, Hu X, Frank Austen K, Baltimore D, Friend DS. Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor Immunity. 3: 175-186. PMID 7648391 DOI: 10.1016/1074-7613(95)90087-X |
0.398 |
|
| 1995 |
Aster J, Pear W, Hasserjian R, Erba H, Davi F, Luo B, Scott M, Baltimore D, Sklar J. Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. Cold Spring Harbor Symposia On Quantitative Biology. 59: 125-36. PMID 7587062 DOI: 10.1101/Sqb.1994.059.01.016 |
0.341 |
|
| 1991 |
Axelson H, Pear WS, Panda CK, Bazin H, Klein G, Sumegi J. Transcriptional deregulation of myc in IgH/myc 6;7 translocation carrying rat immunocytomas Genes Chromosomes and Cancer. 3: 142-148. PMID 1906344 DOI: 10.1002/Gcc.2870030210 |
0.317 |
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