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Todd Golde, MD PhD - Publications

Affiliations: 
Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Alzheimer's disease
Website:
http://www.neuroscience.ufl.edu/faculty+research/golde.html

264 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Colon-Perez LM, Ibanez KR, Suarez M, Torroella K, Acuna K, Ofori E, Levites Y, Vaillancourt DE, Golde TE, Chakrabarty P, Febo M. Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis. Neuroimage. 202: 116138. PMID 31472250 DOI: 10.1016/j.neuroimage.2019.116138  0.76
2019 Ofori E, DeKosky ST, Febo M, Colon-Perez L, Chakrabarty P, Duara R, Adjouadi M, Golde TE, Vaillancourt DE. Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease. Neuroimage. Clinical. 24: 101985. PMID 31470214 DOI: 10.1016/j.nicl.2019.101985  0.44
2019 Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, ... ... Golde TE, et al. An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. The Journal of Experimental Medicine. PMID 31467037 DOI: 10.1084/jem.20190430  0.76
2019 Koller EJ, De La Cruz EG, Machula T, Ibanez KR, Lin WL, Williams T, Riffe CJ, Ryu D, Strang KH, Liu X, Janus C, Golde TE, Dickson D, Giasson BI, Chakrabarty P. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy. Human Molecular Genetics. PMID 31261380 DOI: 10.1093/hmg/ddz151  0.44
2019 Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. The Journal of Biological Chemistry. PMID 31167792 DOI: 10.1074/jbc.RA119.008041  0.68
2019 Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Reports. 27: 1345-1355.e6. PMID 31042463 DOI: 10.1016/j.celrep.2019.03.087  0.68
2019 Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin WL, Deture M, Rodríguez-Lebrón E, Dickson DW, Chakrabarty P, Levites Y, Giasson BI, Golde TE. rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies. The Journal of Experimental Medicine. PMID 30770411 DOI: 10.1084/jem.20182184  0.76
2019 Strang KH, Golde TE, Giasson BI. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30742061 DOI: 10.1038/s41374-019-0197-x  0.36
2019 Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ. Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph. Alzheimer's Research & Therapy. 11: 16. PMID 30711010 DOI: 10.1186/s13195-019-0469-0  0.44
2018 Strang KH, Sorrentino ZA, Riffe CJ, Gorion KM, Vijayaraghavan N, Golde TE, Giasson BI. Phosphorylation of serine 305 in tau inhibits aggregation. Neuroscience Letters. 692: 187-192. PMID 30423399 DOI: 10.1016/j.neulet.2018.11.011  0.36
2018 Lessard CB, Malnik SL, Zhou Y, Ladd TB, Cruz PE, Ran Y, Mahan TE, Chakrabaty P, Holtzman DM, Ulrich JD, Colonna M, Golde TE. High-affinity interactions and signal transduction between Aβ oligomers and TREM2. Embo Molecular Medicine. PMID 30341064 DOI: 10.15252/emmm.201809027  0.68
2018 Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/s41380-018-0258-3  0.68
2018 Hamm M, Ladd TB, Levites Y, Golde TE, Giasson BI, Lewis J. Designing antibodies against LRRK2-targeted tau epitopes. Plos One. 13: e0204367. PMID 30261006 DOI: 10.1371/journal.pone.0204367  0.76
2018 Sorrentino ZA, Xia Y, Funk C, Riffe CJ, Rutherford NJ, Diaz CC, Sacino AN, Price ND, Golde TE, Giasson BI, Chakrabarty P. Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration. Neurobiology of Disease. PMID 30195075 DOI: 10.1016/j.nbd.2018.09.005  0.44
2018 Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, ... ... Golde TE, et al. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease. The Journal of Experimental Medicine. PMID 30158114 DOI: 10.1084/jem.20180484  0.76
2018 Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, ... ... Golde TE, et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathologica. PMID 30136084 DOI: 10.1007/s00401-018-1900-5  0.76
2018 Croft CL, Moore BD, Ran Y, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. Plos One. 13: e0195211. PMID 29608591 DOI: 10.1371/journal.pone.0195211  0.76
2018 Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. 293: 4579. PMID 29572329 DOI: 10.1074/jbc.AAC118.002657  0.44
2018 Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, et al. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimer's Research & Therapy. 10: 22. PMID 29458411 DOI: 10.1186/s13195-018-0349-z  0.76
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Golde TE, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/s13073-018-0516-7  0.76
2017 Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. PMID 29259137 DOI: 10.1074/jbc.M117.815357  0.44
2017 Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, ... ... Golde TE, et al. Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine. PMID 29208777 DOI: 10.1084/jem.20170600  0.76
2017 Strickland MR, Koller EJ, Deng DZ, Ceballos-Diaz C, Golde TE, Chakrabarty P. Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration. Neurobiology of Disease. 110: 133-141. PMID 29196213 DOI: 10.1016/j.nbd.2017.11.007  0.68
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Golde TE, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/s13073-017-0486-1  0.76
2017 Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, ... ... Golde TE, et al. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29107053 DOI: 10.1016/j.jalz.2017.09.012  0.76
2017 Dhillon JS, Riffe C, Moore BD, Ran Y, Chakrabarty P, Golde TE, Giasson BI. A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies. Plos One. 12: e0184731. PMID 28910367 DOI: 10.1371/journal.pone.0184731  0.68
2017 Strang KH, Goodwin MS, Riffe C, Moore BD, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta Neuropathologica Communications. 5: 58. PMID 28760159 DOI: 10.1186/s40478-017-0458-0  0.76
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Golde TE, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/ng.3916  0.56
2017 Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario AM, Golde TE, Li Q. Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice. Scientific Reports. 7: 3222. PMID 28607377 DOI: 10.1038/s41598-017-03397-2  0.68
2017 McFarland NR, McFarland KN, Golde TE. Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy? Jama Neurology. PMID 28586798 DOI: 10.1001/jamaneurol.2017.0843  0.6
2017 Sorrentino ZA, Brooks MMT, Hudson V, Rutherford NJ, Golde TE, Giasson BI, Chakrabarty P. Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity. Molecular Neurodegeneration. 12: 40. PMID 28552073 DOI: 10.1186/s13024-017-0182-z  0.44
2017 Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE. γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct. Embo Molecular Medicine. PMID 28539479 DOI: 10.15252/emmm.201607265  0.68
2017 Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, et al. A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Plos One. 12: e0173565. PMID 28467418 DOI: 10.1371/journal.pone.0173565  0.44
2017 Koller EJ, Brooks MM, Golde TE, Giasson BI, Chakrabarty P. Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice. Molecular Neurodegeneration. 12: 1. PMID 28049533 DOI: 10.1186/s13024-016-0142-z  0.44
2016 Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, ... ... Golde TE, et al. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27939925 DOI: 10.1016/j.jalz.2016.10.005  0.76
2016 Leclerc JL, Santiago-Moreno J, Dang A, Lampert AS, Cruz PE, Rosario AM, Golde TE, Doré S. Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27864463 DOI: 10.1177/0271678X16679170  0.68
2016 Allen M, Carrasquillo MM, Funk C, Heavner BD, Zou F, Younkin CS, Burgess JD, Chai HS, Crook J, Eddy JA, Li H, Logsdon B, Peters MA, Dang KK, Wang X, ... ... Golde TE, et al. Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases. Scientific Data. 3: 160089. PMID 27727239 DOI: 10.1038/sdata.2016.89  0.76
2016 Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE. Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 27531960 DOI: 10.1073/pnas.1608045113  0.76
2016 Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochemical and Biophysical Research Communications. PMID 27425247 DOI: 10.1016/j.bbrc.2016.07.015  0.64
2016 Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology. Journal of Neurochemistry. PMID 27424880 DOI: 10.1111/jnc.13743  0.68
2016 Rosario AM, Cruz PE, Ceballos-Diaz C, Strickland MR, Siemienski Z, Pardo M, Schob KL, Li A, Aslanidi GV, Srivastava A, Golde TE, Chakrabarty P. Microglia-specific targeting by novel capsid-modified AAV6 vectors. Molecular Therapy. Methods & Clinical Development. 3: 16026. PMID 27308302 DOI: 10.1038/mtm.2016.26  0.68
2016 Allen M, Burgess JD, Ballard T, Serie D, Wang X, Younkin CS, Sun Z, Kouri N, Baheti S, Wang C, Carrasquillo MM, Nguyen T, Lincoln S, Malphrus K, Murray M, ... Golde TE, et al. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. Acta Neuropathologica. PMID 27115769 DOI: 10.1007/s00401-016-1576-7  1
2015 Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). Plos One. 10: e0144758. PMID 26678856 DOI: 10.1371/journal.pone.0144758  1
2015 Bean LA, Kumar A, Rani A, Guidi M, Rosario AM, Cruz PE, Golde TE, Foster TC. Re-Opening the Critical Window for Estrogen Therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 16077-16093. PMID 26658861 DOI: 10.1523/JNEUROSCI.1890-15.2015  0.68
2015 Xu G, Ran Y, Fromholt SE, Fu C, Yachnis AT, Golde TE, Borchelt DR. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathologica Communications. 3: 72. PMID 26566997 DOI: 10.1186/s40478-015-0252-9  0.36
2015 Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathologica. PMID 26541429 DOI: 10.1007/s00401-015-1505-1  0.68
2015 Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, Levites Y, Rincon-Limas DE. Anti-Aβ single chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease. Human Molecular Genetics. PMID 26253732 DOI: 10.1093/hmg/ddv321  1
2015 Ling IF, Golde TE, Galasko DR, Koo EH. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimer's Research & Therapy. 7: 55. PMID 26244059 DOI: 10.1186/s13195-015-0137-y  1
2015 Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI. Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice. Molecular Neurodegeneration. 10: 32. PMID 26223783 DOI: 10.1186/s13024-015-0029-4  0.68
2015 Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Molecular Neurodegeneration. 10: 29. PMID 26169917 DOI: 10.1186/s13024-015-0021-z  0.68
2015 Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. IFN-γ promotes τ phosphorylation without affecting mature tangles. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26156074 DOI: 10.1096/fj.15-275834  0.68
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice. Molecular Neurodegeneration. 10: 25. PMID 26152284 DOI: 10.1186/s13024-015-0026-7  0.68
2015 Ran Y, Ladd GZ, Ceballos-Diaz C, Jung JI, Greenbaum D, Felsenstein KM, Golde TE. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. Plos One. 10: e0128619. PMID 26046535 DOI: 10.1371/journal.pone.0128619  0.68
2015 Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, Stanculescu A, Bocchetta M, Rizzo P, Band V, Band H, Kim HM, Park SK, Kang KW, Avantaggiati ML, ... ... Golde T, et al. p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex via MAML1. Journal of Cellular Physiology. PMID 26033683 DOI: 10.1002/jcp.25052  1
2015 Chakrabarty P, Hudson Iii VJ, Sacino AN, Brooks MM, D'Alton S, Lewis J, Golde TE, Giasson BI. Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission. Acta Neuropathologica. 130: 303-5. PMID 25982997 DOI: 10.1007/s00401-015-1444-x  0.68
2015 Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM. The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity. The Embo Journal. 34: 1674-86. PMID 25964433 DOI: 10.15252/embj.201488795  0.68
2015 Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, ... Golde TE, et al. A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6265-76. PMID 25904780 DOI: 10.1523/JNEUROSCI.5109-14.2015  1
2015 Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, ... Golde TE, et al. IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron. 85: 519-33. PMID 25619653 DOI: 10.1016/j.neuron.2014.11.020  0.68
2015 Ofori E, Pasternak O, Planetta PJ, Burciu R, Snyder A, Febo M, Golde TE, Okun MS, Vaillancourt DE. Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study. Neurobiology of Aging. 36: 1097-104. PMID 25467638 DOI: 10.1016/j.neurobiolaging.2014.10.029  1
2015 Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 53-62. PMID 25228069 DOI: 10.1038/mt.2014.180  0.68
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice Molecular Neurodegeneration. DOI: 10.1186/s13024-015-0026-7  0.68
2014 Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. Plos One. 9: e111553. PMID 25350374 DOI: 10.1371/journal.pone.0111553  1
2014 Kim JY, Grunke SD, Levites Y, Golde TE, Jankowsky JL. Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction. Journal of Visualized Experiments : Jove. 51863. PMID 25286085 DOI: 10.3791/51863  0.68
2014 Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI. Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12368-78. PMID 25209277 DOI: 10.1523/JNEUROSCI.2102-14.2014  0.68
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10732-7. PMID 25002524 DOI: 10.1073/pnas.1321785111  0.68
2014 Rutherford NJ, Moore BD, Golde TE, Giasson BI. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. Journal of Neurochemistry. 131: 859-67. PMID 24984882 DOI: 10.1111/jnc.12806  0.68
2014 Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM. NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Frontiers in Immunology. 5: 249. PMID 24904593 DOI: 10.3389/fimmu.2014.00249  0.68
2014 March A, Borchelt D, Golde T, Janus C. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning. Comparative Medicine. 64: 4-12. PMID 24672832  0.68
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathologica. 127: 645-65. PMID 24659240 DOI: 10.1007/s00401-014-1268-0  0.68
2014 Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3826-40. PMID 24623762 DOI: 10.1523/JNEUROSCI.5171-13.2014  0.68
2014 Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 53: 1947-57. PMID 24620716 DOI: 10.1021/bi401521t  0.68
2014 Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA. Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. Frontiers in Immunology. 5: 54. PMID 24611064 DOI: 10.3389/fimmu.2014.00054  0.68
2014 Golde TE. Open questions for Alzheimer's disease immunotherapy. Alzheimer's Research & Therapy. 6: 3. PMID 24393284 DOI: 10.1186/alzrt233  0.68
2014 Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE. γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells. The Journal of Biological Chemistry. 289: 3276-87. PMID 24352661 DOI: 10.1074/jbc.M113.512921  0.68
2014 Janus C, Golde T. The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice. Behavioural Brain Research. 259: 253-60. PMID 24239696 DOI: 10.1016/j.bbr.2013.11.010  0.68
2013 Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathologica Communications. 1: 38. PMID 24252149 DOI: 10.1186/2051-5960-1-38  0.68
2013 Golde TE, Lewis J, McFarland NR. Anti-tau antibodies: hitting the target. Neuron. 80: 254-6. PMID 24139027 DOI: 10.1016/j.neuron.2013.10.009  0.68
2013 Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, ... ... Golde TE, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/JCI69003  0.68
2013 Chakrabarty P, Rosario A, Cruz P, Siemienski Z, Ceballos-Diaz C, Crosby K, Jansen K, Borchelt DR, Kim JY, Jankowsky JL, Golde TE, Levites Y. Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. Plos One. 8: e67680. PMID 23825679 DOI: 10.1371/journal.pone.0067680  0.68
2013 Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. γ-Secretase inhibitors and modulators. Biochimica Et Biophysica Acta. 1828: 2898-907. PMID 23791707 DOI: 10.1016/j.bbamem.2013.06.005  0.68
2013 Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/j.brainres.2013.06.006  0.68
2013 Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, Andrzejewski C, Fauq AH, Golde TE, Miele L, Minter LM. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. The Journal of Experimental Medicine. 210: 1311-29. PMID 23733784 DOI: 10.1084/jem.20112615  0.68
2013 Galasko D, Golde TE, Scheltens P. Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full? Alzheimer's Research & Therapy. 5: 26. PMID 23731836 DOI: 10.1186/alzrt180  0.68
2013 Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Steroids as γ-secretase modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3775-85. PMID 23716494 DOI: 10.1096/fj.12-225649  0.68
2013 Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular Neurodegeneration. 8: 17. PMID 23714769 DOI: 10.1186/1750-1326-8-17  0.68
2013 Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE, Felsenstein KM. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-d. PMID 23704553 DOI: 10.1126/science.1234089  0.68
2013 Golde TE, Streit WJ, Chakrabarty P. Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 24. PMID 23692967 DOI: 10.1186/alzrt178  0.68
2013 Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/s00401-013-1123-8  0.68
2013 Kim J, Chakrabarty P, Hanna A, March A, Dickson DW, Borchelt DR, Golde T, Janus C. Normal cognition in transgenic BRI2-Aβ mice. Molecular Neurodegeneration. 8: 15. PMID 23663320 DOI: 10.1186/1750-1326-8-15  0.68
2013 Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/JCI66029  0.68
2013 Galasko D, Golde TE. Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems. Alzheimer's Research & Therapy. 5: 10. PMID 23470193 DOI: 10.1186/alzrt164  0.68
2013 Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3765-79. PMID 23447589 DOI: 10.1523/JNEUROSCI.4251-12.2013  0.68
2013 Chu J, Li JG, Ceballos-Diaz C, Golde T, Praticò D. The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence. Biological Psychiatry. 74: 321-8. PMID 23352590 DOI: 10.1016/j.biopsych.2012.12.012  0.68
2013 Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. The European Journal of Neuroscience. 37: 1203-20. PMID 23347239 DOI: 10.1111/ejn.12126  0.68
2012 Tebbenkamp AT, Crosby KW, Siemienski ZB, Brown HH, Golde TE, Borchelt DR. Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model. Plos One. 7: e50750. PMID 23236391 DOI: 10.1371/journal.pone.0050750  0.68
2012 Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proceedings of the National Academy of Sciences of the United States of America. 109: 21486-91. PMID 23236186 DOI: 10.1073/pnas.1216016110  0.68
2012 Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of Medicinal Chemistry. 55: 10749-65. PMID 23181502 DOI: 10.1021/jm301630s  0.68
2012 Verbeeck C, Deng Q, Dejesus-Hernandez M, Taylor G, Ceballos-Diaz C, Kocerha J, Golde T, Das P, Rademakers R, Dickson DW, Kukar T. Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis. Molecular Neurodegeneration. 7: 53. PMID 23046583 DOI: 10.1186/1750-1326-7-53  0.68
2012 Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP). The Journal of Biological Chemistry. 287: 40629-40. PMID 23043097 DOI: 10.1074/jbc.M112.418442  0.68
2012 Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D. 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Annals of Neurology. 72: 442-54. PMID 23034916 DOI: 10.1002/ana.23642  0.68
2012 Cao L, Schrank BR, Rodriguez S, Benz EG, Moulia TW, Rickenbacher GT, Gomez AC, Levites Y, Edwards SR, Golde TE, Hyman BT, Barnea G, Albers MW. Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature Communications. 3: 1009. PMID 22910355 DOI: 10.1038/ncomms2013  0.68
2012 Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, et al. β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. Embo Molecular Medicine. 4: 980-91. PMID 22903875 DOI: 10.1002/emmm.201101084  0.68
2012 Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/JNEUROSCI.0757-12.2012  0.68
2012 Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE. Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular Neurodegeneration. 7: 39. PMID 22892055 DOI: 10.1186/1750-1326-7-39  0.68
2012 Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE. Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition. Molecular Neurodegeneration. 7: 36. PMID 22838967 DOI: 10.1186/1750-1326-7-36  0.68
2012 Hanna A, Iremonger K, Das P, Dickson D, Golde T, Janus C. Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis. Alzheimer's Research & Therapy. 4: 21. PMID 22697412 DOI: 10.1186/alzrt124  0.68
2012 Moore BD, Chakrabarty P, Levites Y, Kukar TL, Baine AM, Moroni T, Ladd TB, Das P, Dickson DW, Golde TE. Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains. Alzheimer's Research & Therapy. 4: 18. PMID 22621179 DOI: 10.1186/alzrt121  0.68
2012 Galasko D, Golde T, Wilcock G. Recent Alzheimer's disease research highlights. Alzheimer's Research & Therapy. 4: 14. PMID 22594696 DOI: 10.1186/alzrt117  0.68
2012 Golde TE, Ran Y, Felsenstein KM. Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease. The Embo Journal. 31: 2237-9. PMID 22505028 DOI: 10.1038/emboj.2012.111  0.68
2012 Gu JW, Rizzo P, Pannuti A, Golde T, Osborne B, Miele L. Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy. Vascular Cell. 4: 7. PMID 22487493 DOI: 10.1186/2045-824X-4-7  0.68
2012 Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratico D. Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Molecular Neurodegeneration. 7: 1. PMID 22222029 DOI: 10.1186/1750-1326-7-1  0.68
2011 Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. Plos One. 6: e27221. PMID 22174738 DOI: 10.1371/journal.pone.0027221  0.68
2011 Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. Plos One. 6: e27019. PMID 22069482 DOI: 10.1371/journal.pone.0027019  0.68
2011 Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 39794-803. PMID 21868380 DOI: 10.1074/jbc.M111.277228  0.68
2011 Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, ... Golde TE, et al. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. The Journal of Biological Chemistry. 286: 39804-12. PMID 21868378 DOI: 10.1074/jbc.M111.274696  0.68
2011 Chakrabarty P, Ceballos-Diaz C, Lin WL, Beccard A, Jansen-West K, McFarland NR, Janus C, Dickson D, Das P, Golde TE. Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification. Nature Neuroscience. 14: 694-6. PMID 21572432 DOI: 10.1038/nn.2829  0.68
2011 Golde TE, Lamb BT, Galasko D. Right sizing funding for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 17. PMID 21554753 DOI: 10.1186/alzrt76  0.68
2011 Wang A, Das P, Switzer RC, Golde TE, Jankowsky JL. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4124-36. PMID 21411653 DOI: 10.1523/JNEUROSCI.5077-10.2011  0.68
2011 Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE. Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo. Molecular Neurodegeneration. 6: 16. PMID 21324189 DOI: 10.1186/1750-1326-6-16  0.68
2011 Golde TE, Schneider LS, Koo EH. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 69: 203-13. PMID 21262461 DOI: 10.1016/j.neuron.2011.01.002  0.68
2010 Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G. Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16160-9. PMID 21123562 DOI: 10.1523/JNEUROSCI.4436-10.2010  0.68
2010 Lewis J, Golde TE. Sorting out frontotemporal dementia? Neuron. 68: 601-3. PMID 21092851 DOI: 10.1016/j.neuron.2010.11.014  0.68
2010 Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, et al. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15374-82. PMID 21084594 DOI: 10.1523/JNEUROSCI.3155-10.2010  0.68
2010 Grudzien P, Lo S, Albain KS, Robinson P, Rajan P, Strack PR, Golde TE, Miele L, Foreman KE. Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer Research. 30: 3853-67. PMID 21036696  0.68
2010 Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of Neuroscience Methods. 194: 144-53. PMID 20951738 DOI: 10.1016/j.jneumeth.2010.10.010  0.68
2010 Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L. Targeting Notch to target cancer stem cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3141-52. PMID 20530696 DOI: 10.1158/1078-0432.CCR-09-2823  1
2010 Chakrabarty P, Ceballos-Diaz C, Beccard A, Janus C, Dickson D, Golde TE, Das P. IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 5333-43. PMID 20368278 DOI: 10.4049/jimmunol.0903382  1
2010 De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218  1
2010 Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P. Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 548-59. PMID 19825975 DOI: 10.1096/fj.09-141754  1
2010 Golde TE, Petrucelli L, Lewis J. Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental Neurology. 223: 252-66. PMID 19716367 DOI: 10.1016/j.expneurol.2009.07.035  1
2010 Chakrabarty P, Das P, Golde TE. Current and Future Therapies for Alzheimer Disease Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 711-774. DOI: 10.1002/9780470572702.ch34  1
2009 Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/bi901237k  1
2009 Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neuroscience. 12: 1300-7. PMID 19734892 DOI: 10.1038/nn.2395  1
2009 Donnelly A, Galasko D, Golde T, Mulvany F, Wilcock G. Welcome to Alzheimer's research & therapy. Alzheimer's Research & Therapy. 1: 1. PMID 19671199 DOI: 10.1186/alzrt1  1
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: doi:10.1038/mt.2009.174  1
2009 Golde TE, Wolfe MS, Greenbaum DC. Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins. Seminars in Cell & Developmental Biology. 20: 225-30. PMID 19429495 DOI: 10.1016/j.semcdb.2009.02.003  1
2009 Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19  1
2009 Golde TE, Kukar TL. Medicine. Avoiding unintended toxicity. Science (New York, N.Y.). 324: 603-4. PMID 19407192 DOI: 10.1126/science.1174267  1
2009 Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 7607-12. PMID 19383787 DOI: 10.1073/pnas.0900688106  1
2009 Rizzo P, Osipo C, Pannuti A, Golde T, Osborne B, Miele L. Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer. Advances in Enzyme Regulation. 49: 134-41. PMID 19344631 DOI: 10.1016/j.advenzreg.2009.01.008  1
2009 Parvanova I, Epiphanio S, Fauq A, Golde TE, Prudêncio M, Mota MM. A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. Plos One. 4: e5078. PMID 19337374 DOI: 10.1371/journal.pone.0005078  1
2009 McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiology of Disease. 34: 163-77. PMID 19320056 DOI: 10.1016/j.nbd.2009.01.006  1
2009 Rahimi N, Golde TE, Meyer RD. Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer Research. 69: 2607-14. PMID 19276374 DOI: 10.1158/0008-5472.CAN-08-2905  1
2009 Golde TE, Das P, Levites Y. Quantitative and mechanistic studies of Abeta immunotherapy. Cns & Neurological Disorders Drug Targets. 8: 31-49. PMID 19275635 DOI: 10.2174/187152709787601830  1
2009 Cho OH, Shin HM, Miele L, Golde TE, Fauq A, Minter LM, Osborne BA. Notch regulates cytolytic effector function in CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 3380-9. PMID 19265115 DOI: 10.4049/jimmunol.0802598  1
2009 Golde TE. The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease. Molecular Neurodegeneration. 4: 8. PMID 19193222 DOI: 10.1186/1750-1326-4-8  1
2009 Golde TE, Petrucelli L. "What kills neurons in neurodegenerative diseases?", a review series in an open access journal. Molecular Neurodegeneration. 4: 7. PMID 19193221 DOI: 10.1186/1750-1326-4-7  1
2009 Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 113: 1689-98. PMID 19001083 DOI: 10.1182/blood-2008-03-147967  1
2008 Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 27: 5124-31. PMID 18758481 DOI: 10.1038/onc.2008.226  1
2008 Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ. A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains. Proceedings of the National Academy of Sciences of the United States of America. 105: 10595-600. PMID 18647832 DOI: 10.1073/pnas.0803671105  1
2008 Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood. 112: 1813-21. PMID 18550850 DOI: 10.1182/blood-2008-03-144980  1
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, ... ... Golde TE, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/nature07055  1
2008 Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, ... ... Golde TE, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6030-6. PMID 18524908 DOI: 10.1523/JNEUROSCI.0891-08.2008  1
2008 Jiang P, Ko LW, Jansen KR, Golde TE, Yen SH. Using leucine zipper to facilitate alpha-synuclein assembly. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3165-74. PMID 18492724 DOI: 10.1096/fj.08-108365  1
2008 Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene. 27: 5019-32. PMID 18469855 DOI: 10.1038/onc.2008.149  1
2008 Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/jbc.M802912200  1
2008 Buxbaum JN, Ye Z, Reixach N, Friske L, Levy C, Das P, Golde T, Masliah E, Roberts AR, Bartfai T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 2681-6. PMID 18272491 DOI: 10.1073/pnas.0712197105  1
2008 Kukar T, Golde TE. Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage. Current Topics in Medicinal Chemistry. 8: 47-53. PMID 18220932 DOI: 10.2174/156802608783334042  1
2008 Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH, Osborne BA. Notch signaling is activated by TLR stimulation and regulates macrophage functions. European Journal of Immunology. 38: 174-83. PMID 18085664 DOI: 10.1002/eji.200636999  1
2008 Osipo C, Golde TE, Osborne BA, Miele LA. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 11-7. PMID 18059366 DOI: 10.1038/labinvest.3700700  1
2007 Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Disease and Associated Disorders. 21: 292-9. PMID 18090435 DOI: 10.1097/WAD.0b013e31815d1048  1
2007 Fauq AH, Simpson K, Maharvi GM, Golde T, Das P. A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. Bioorganic & Medicinal Chemistry Letters. 17: 6392-5. PMID 17897827 DOI: 10.1016/j.bmcl.2007.07.062  1
2007 Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. The Journal of Biological Chemistry. 282: 32264-73. PMID 17827153 DOI: 10.1074/jbc.M703649200  1
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  1
2007 Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. The Journal of Biological Chemistry. 282: 26832-44. PMID 17646164 DOI: 10.1074/jbc.M702640200  1
2007 Curry CL, Reed LL, Broude E, Golde TE, Miele L, Foreman KE. Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling. Molecular Cancer Therapeutics. 6: 1983-92. PMID 17604336 DOI: 10.1158/1535-7163.MCT-07-0093  1
2007 Lawlor PA, Bland RJ, Das P, Price RW, Holloway V, Smithson L, Dicker BL, During MJ, Young D, Golde TE. Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels. Molecular Neurodegeneration. 2: 11. PMID 17559680 DOI: 10.1186/1750-1326-2-11  1
2007 Kim J, Onstead L, Randle S, Price R, Smithson L, Zwizinski C, Dickson DW, Golde T, McGowan E. Abeta40 inhibits amyloid deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 627-33. PMID 17234594 DOI: 10.1523/JNEUROSCI.4849-06.2007  1
2007 Golde TE. The pathogenesis of Alzheimer's disease and the role of Abeta42. Cns Spectrums. 12: 4-6. PMID 17192766  1
2007 Golde TE. Chapter 1 Amyloid and Amyloid-Like Protein Aggregates in Neurodegenerative Disease Blue Books of Neurology. 30: 1-32. DOI: 10.1016/S1877-184X(09)70052-8  1
2007 Golde T. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 406.  1
2007 Kennedy GJ, Golde TE, Tariot PN, Cummings JL. Amyloid-based interventions in Alzheimer's disease Cns Spectrums. 12: 1-14.  1
2006 Miele L, Golde T, Osborne B. Notch signaling in cancer. Current Molecular Medicine. 6: 905-18. PMID 17168741 DOI: 10.2174/156652406779010830  1
2006 Golde TE, Dickson D, Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Current Alzheimer Research. 3: 421-30. PMID 17168641 DOI: 10.2174/156720506779025189  1
2006 Levites Y, Jansen K, Smithson LA, Dakin R, Holloway VM, Das P, Golde TE. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11923-8. PMID 17108166 DOI: 10.1523/JNEUROSCI.2795-06.2006  1
2006 Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Molecular Neurodegeneration. 1: 16. PMID 17105660 DOI: 10.1186/1750-1326-1-16  1
2006 Das P, Golde T. Dysfunction of TGF-beta signaling in Alzheimer's disease. The Journal of Clinical Investigation. 116: 2855-7. PMID 17080189 DOI: 10.1172/JCI30284  1
2006 Golde TE. Disease modifying therapy for AD? Journal of Neurochemistry. 99: 689-707. PMID 17076654 DOI: 10.1111/j.1471-4159.2006.04211.x  1
2006 Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2576-8. PMID 17068112 DOI: 10.1096/fj.06-6463fje  1
2006 Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR, Kantarci K, Shiung MM, Golde T, Smith GE, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain : a Journal of Neurology. 129: 3103-14. PMID 17030535 DOI: 10.1093/brain/awl268  1
2006 Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Molecular Neurodegeneration. 1: 3. PMID 16930450 DOI: 10.1186/1750-1326-1-3  1
2006 Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1671-9. PMID 16873890 DOI: 10.1096/fj.06-5762com  1
2006 Das P, Smithson LA, Price RW, Holloway VM, Levites Y, Chakrabarty P, Golde TE. Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy. Journal of Neuroinflammation. 3: 17. PMID 16872492 DOI: 10.1186/1742-2094-3-17  1
2006 Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry. 45: 8649-56. PMID 16834339 DOI: 10.1021/bi060597g  1
2006 Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, Castanedes-Casey M, Genco P, Golde T, Richelson E, Dickson D, McKinney M, Eckman CB. Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. Journal of Hepatology. 44: 1105-14. PMID 16458990 DOI: 10.1016/j.jhep.2005.09.019  1
2006 Murphy MP, Golde TE. Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology. 66: S65-8. PMID 16432148 DOI: 10.1212/01.wnl.0000192108.02654.ac  1
2006 Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochemical and Biophysical Research Communications. 340: 668-74. PMID 16376853 DOI: 10.1016/j.bbrc.2005.12.063  1
2006 Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 116: 193-201. PMID 16341263 DOI: 10.1172/JCI25410  1
2006 Klein RL, Dayton RD, Leidenheimer NJ, Jansen K, Golde TE, Zweig RM. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 517-27. PMID 16325474 DOI: 10.1016/j.ymthe.2005.10.008  1
2006 Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. The Embo Journal. 25: 129-38. PMID 16319921 DOI: 10.1038/sj.emboj.7600902  1
2006 Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of Neurochemistry. 96: 218-27. PMID 16305624 DOI: 10.1111/j.1471-4159.2005.03548.x  1
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/j.1471-4159.2005.03553.x  1
2006 Guojun B, Huaxi X, Golde TE. Zoom in on neurodegeneration Molecular Neurodegeneration. 1. DOI: 10.1186/1750-1326-1-1  1
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, ... ... Golde T, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/j.neuron.2005.06.030  1
2005 Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, ... Golde TE, et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunology. 6: 680-8. PMID 15991363 DOI: 10.1038/ni1209  1
2005 Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene. 24: 6333-44. PMID 15940249 DOI: 10.1038/sj.onc.1208783  1
2005 Golde TE, Bacskai BJ. Bringing amyloid into focus. Nature Biotechnology. 23: 552-4. PMID 15877070 DOI: 10.1038/nbt0505-552  1
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, ... ... Golde TE, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/nm1235  1
2005 Golde TE. The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease. Brain Pathology (Zurich, Switzerland). 15: 84-7. PMID 15779241  1
2005 Golde TE, Janus C. Homing in on intracellular Abeta? Neuron. 45: 639-42. PMID 15748837 DOI: 10.1016/j.neuron.2005.02.013  1
2004 Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochemical and Biophysical Research Communications. 322: 1145-52. PMID 15336962 DOI: 10.1016/j.bbrc.2004.07.136  1
2004 Nyborg AC, Jansen K, Ladd TB, Fauq A, Golde TE. A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin. The Journal of Biological Chemistry. 279: 43148-56. PMID 15252014 DOI: 10.1074/jbc.M405879200  1
2004 Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. The Journal of Biological Chemistry. 279: 15153-60. PMID 14704149 DOI: 10.1074/jbc.M309305200  1
2003 Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ. Androgens modulate beta-amyloid levels in male rat brain. Journal of Neurochemistry. 87: 1052-5. PMID 14622134 DOI: 10.1046/j.1471-4159.2003.02114.x  1
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8532-8. PMID 13679422  1
2003 Martoglio B, Golde TE. Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Human Molecular Genetics. 12: R201-6. PMID 12966028 DOI: 10.1093/hmg/ddg303  1
2003 Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 3019-24. PMID 12960327  1
2003 Das P, Chapoval S, Howard V, David CS, Golde TE. Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies. Neurobiology of Aging. 24: 969-76. PMID 12928057 DOI: 10.1016/S0197-4580(03)00036-8  1
2003 Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. The Journal of Clinical Investigation. 112: 440-9. PMID 12897211 DOI: 10.1172/JCI18162  1
2003 Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39: 409-21. PMID 12895417 DOI: 10.1016/S0896-6273(03)00434-3  1
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of Biological Chemistry. 278: 31831-7. PMID 12805356 DOI: 10.1074/jbc.M303592200  1
2003 Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. The Journal of Biological Chemistry. 278: 31825-30. PMID 12805355 DOI: 10.1074/jbc.M303588200  1
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. The Journal of Biological Chemistry. 278: 30748-54. PMID 12777371 DOI: 10.1074/jbc.M304824200  1
2003 Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Peptide-based, irreversible inhibitors of gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 529-33. PMID 12763025 DOI: 10.1016/S0006-291X(03)00828-3  1
2003 Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Overexpression of nicastrin increases Abeta production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1138-40. PMID 12692078 DOI: 10.1096/fj.02-1050fje  1
2003 Golde TE, Eckman CB. Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Science's Stke : Signal Transduction Knowledge Environment. 2003: RE4. PMID 12621149 DOI: 10.1126/stke.2003.172.re4  1
2002 Das P, Golde TE. Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al. Neurobiology of Aging. 23: 671-4; discussion 68. PMID 12392769  0.76
2002 Tang-Wai D, Lewis P, Boeve B, Hutton M, Golde T, Baker M, Hardy J, Michels V, Ivnik R, Jack C, Petersen R. Familial frontotemporal dementia associated with a novel presenilin-1 mutation. Dementia and Geriatric Cognitive Disorders. 14: 13-21. PMID 12053127  0.44
2002 Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE. Identification of a novel family of presenilin homologues. Human Molecular Genetics. 11: 1037-44. PMID 11978763  1
2002 Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 99: 6334-9. PMID 11972038 DOI: 10.1073/pnas.082545599  1
2002 Murphy MP, Uljon SN, Golde TE, Wang R. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. Biochimica Et Biophysica Acta. 1586: 199-209. PMID 11959461 DOI: 10.1016/S0925-4439(01)00098-9  1
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/pnas.072033799  1
2002 Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of Disease. 9: 269-73. PMID 11895378 DOI: 10.1006/nbdi.2001.0473  1
2002 Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of Disease. 9: 11-23. PMID 11848681 DOI: 10.1006/nbdi.2001.0470  1
2001 McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. Brain Research. Molecular Brain Research. 97: 103-13. PMID 11744168 DOI: 10.1016/S0169-328X(01)00294-7  1
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  1
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  1
2001 Ni CY, Murphy MP, Golde TE, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (New York, N.Y.). 294: 2179-81. PMID 11679632 DOI: 10.1126/science.1065412  1
2001 Golde TE, Eckman CB. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discovery Today. 6: 1049-1055. PMID 11590033 DOI: 10.1016/S1359-6446(01)01965-1  1
2001 Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. The Journal of Biological Chemistry. 276: 38563-9. PMID 11504726 DOI: 10.1074/jbc.M105376200  1
2001 Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG, Eckman CB. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). Journal of Neuroscience Methods. 108: 171-9. PMID 11478976 DOI: 10.1016/S0165-0270(01)00388-0  1
2001 Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochimica Et Biophysica Acta. 1537: 58-62. PMID 11476963 DOI: 10.1016/S0925-4439(01)00054-0  1
2001 Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, Sheppard P, Makoff A, Gower E, Soden PE, Lewis P, ... ... Golde TE, et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4987-95. PMID 11438574  1
2001 Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends in Molecular Medicine. 7: 264-9. PMID 11378516 DOI: 10.1016/S1471-4914(01)02064-0  1
2001 Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, et al. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 16-18. PMID 11099491 DOI: 10.1096/fj.00-0528fje  1
2001 Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, Ziani-Cherif C, Onstead L, Sambamurti K. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. The Journal of Biological Chemistry. 276: 481-7. PMID 11035007 DOI: 10.1074/jbc.M005968200  0.4
2000 Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. An empirical model of gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 233-40. PMID 11193156  1
2000 Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, ... ... Golde T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::AID-ANA18>3.0.CO;2-F  1
2000 Lewis PA, Perez-Tur J, Golde TE, Hardy J. The presenilin 1 C92S mutation increases abeta 42 production. Biochemical and Biophysical Research Communications. 277: 261-3. PMID 11027672 DOI: 10.1006/bbrc.2000.3646  1
2000 McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2383-6. PMID 11024004 DOI: 10.1096/fj.00-0286fje  1
2000 Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochimica Et Biophysica Acta. 1502: 172-87. PMID 10899442 DOI: 10.1016/S0925-4439(00)00043-0  1
2000 Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. The Journal of Biological Chemistry. 275: 26277-84. PMID 10816583 DOI: 10.1074/jbc.M002812200  1
1999 Rennert H, Golde T, Wilson RB, Spitalnik SL, Van Deerlin VM, Leonard DG. A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: a comparative study of RT-PCR cytogenetics, and fluorescence In situ hybridization. Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology. 4: 195-209. PMID 10553020 DOI: 10.154/MODI00400195  1
1999 Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length. The Journal of Biological Chemistry. 274: 11914-23. PMID 10207012 DOI: 10.1074/jbc.274.17.11914  1
1996 Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM, Doms RW. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proceedings of the National Academy of Sciences of the United States of America. 93: 9223-8. PMID 8799182 DOI: 10.1073/pnas.93.17.9223  1
1994 Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Eckman C, Golde TE, Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (New York, N.Y.). 264: 1336-40. PMID 8191290  1
1994 Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG. Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. Annals of Neurology. 36: 903-11. PMID 7998778 DOI: 10.1002/ana.410360616  1
1993 Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science (New York, N.Y.). 259: 514-6. PMID 8424174  1
1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 9513-7. PMID 8415732  1
1993 Kalaria RN, Golde T, Kroon SN, Perry G. Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease. The American Journal of Pathology. 143: 886-93. PMID 8362984  0.4
1993 Golde TE, Cai XD, Shoji M, Younkin SG. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 103-8. PMID 8239266 DOI: 10.1111/j.1749-6632.1993.tb23036.x  1
1992 Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847  1
1992 Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science (New York, N.Y.). 255: 726-8. PMID 1738846  1
1992 Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (New York, N.Y.). 258: 126-9. PMID 1439760  1
1992 Gillespie SL, Golde TE, Younkin SG. Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochemical and Biophysical Research Communications. 187: 1285-90. PMID 1417805 DOI: 10.1016/0006-291X(92)90442-N  1
1992 Estus S, Golde TE, Younkin SG. Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives. Annals of the New York Academy of Sciences. 674: 138-48. PMID 1288359  1
1991 Kalaria RN, Golde TE, Cohen ML, Younkin SG. Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier. Annals of the New York Academy of Sciences. 640: 145-8. PMID 1776732  1
1990 Golde TE, Estus S, Usiak M, Younkin LH, Younkin SG. Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron. 4: 253-67. PMID 2106330 DOI: 10.1016/0896-6273(90)90100-T  1
1990 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Advances in Neurology. 51: 181-4. PMID 2104687  1
1989 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Progress in Clinical and Biological Research. 317: 971-84. PMID 2513588  1
1988 Cohen ML, Golde TE, Usiak MF, Younkin LH, Younkin SG. In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 85: 1227-31. PMID 3277188  1
1988 Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the IgA heavy chain gene in the genus Mus. Genetics. 119: 925-31. PMID 2842228  1
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  1
1986 Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the mouse IgA gene: nucleotide sequence comparison of IgA in BALB/c and Mus pahari. Current Topics in Microbiology and Immunology. 127: 141-8. PMID 3731840  1
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