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Todd Golde, MD PhD - Publications

Affiliations: 
Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Alzheimer's disease
Website:
http://www.neuroscience.ufl.edu/faculty+research/golde.html
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Year Citation  Score
2024 Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, Perez-Nievas BG, Hanger DP, Noble W, Jimenez-Sanchez M. Reactive astrocytes secrete the chaperone HSPB1 to mediate neuroprotection. Science Advances. 10: eadk9884. PMID 38507480 DOI: 10.1126/sciadv.adk9884  0.766
2024 Guo Q, Ping L, Dammer EB, Yin L, Xu K, Shantaraman A, Fox EJ, Golde TE, Johnson ECB, Roberts BR, Lah JJ, Levey AI, Seyfried NT. Heparin-enriched plasma proteome is significantly altered in Alzheimer's Disease. Research Square. PMID 38464223 DOI: 10.21203/rs.3.rs-3933136/v1  0.307
2024 Wojtas AM, Dammer EB, Guo Q, Ping L, Shantaraman A, Duong DM, Yin L, Fox EJ, Seifar F, Lee EB, Johnson ECB, Lah JJ, Levey AI, Levites Y, Rangaraju S, ... Golde TE, et al. Proteomic Changes in the Human Cerebrovasculature in Alzheimer's Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid. Medrxiv : the Preprint Server For Health Sciences. PMID 38260316 DOI: 10.1101/2024.01.10.24301099  0.35
2023 Golde TE, Levey AI. Immunotherapies for Alzheimer's disease. Science (New York, N.Y.). 382: 1242-1244. PMID 38096276 DOI: 10.1126/science.adj9255  0.34
2023 Levites Y, Dammer EB, Ran Y, Tsering W, Duong D, Abreha M, Gadhavi J, Lolo K, Trejo-Lopez J, Phillips JL, Iturbe A, Erqiuzi A, Moore BD, Ryu D, Natu A, ... ... Golde TE, et al. Aβ Amyloid Scaffolds the Accumulation of Matrisome and Additional Proteins in Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 38076912 DOI: 10.1101/2023.11.29.568318  0.774
2023 Moore BD, Ran Y, Goodwin MS, Komatineni K, McFarland KN, Dillon K, Charles C, Ryu D, Liu X, Prokop S, Giasson BI, Golde TE, Levites Y. A C1qTNF3 collagen domain fusion chaperones diverse secreted proteins and anti-Aβ scFvs: Applications for gene therapies. Molecular Therapy. Methods & Clinical Development. 31: 101146. PMID 38027063 DOI: 10.1016/j.omtm.2023.101146  0.613
2023 Min Y, Wang X, İş Ö, Patel TA, Gao J, Reddy JS, Quicksall ZS, Nguyen T, Lin S, Tutor-New FQ, Chalk JL, Mitchell AO, Crook JE, Nelson PT, Van Eldik LJ, ... Golde TE, et al. Cross species systems biology discovers glial DDR2, STOM, and KANK2 as therapeutic targets in progressive supranuclear palsy. Nature Communications. 14: 6801. PMID 37919278 DOI: 10.1038/s41467-023-42626-3  0.511
2023 Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp MD, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG, Noble W. P2XR influences tau aggregate burden in human tauopathies and shows distinct signalling in microglia and astrocytes. Brain, Behavior, and Immunity. 114: 414-429. PMID 37716378 DOI: 10.1016/j.bbi.2023.09.011  0.815
2022 Croft CL, Paterno G, Vause AR, Rowe LA, Ryu DH, Goodwin MS, Moran CA, Cruz PE, Giasson BI, Golde TE. Optical pulse labeling studies reveal exogenous seeding slows α-synuclein clearance. Npj Parkinson's Disease. 8: 173. PMID 36535953 DOI: 10.1038/s41531-022-00434-4  0.693
2022 Khalil B, Chhangani D, Wren MC, Smith CL, Lee JH, Li X, Puttinger C, Tsai CW, Fortin G, Morderer D, Gao J, Liu F, Lim CK, Chen J, Chou CC, ... ... Golde TE, et al. Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy. Molecular Neurodegeneration. 17: 80. PMID 36482422 DOI: 10.1186/s13024-022-00585-1  0.708
2022 Chen K, Martens YA, Meneses A, Ryu DH, Lu W, Raulin AC, Li F, Zhao J, Chen Y, Jin Y, Linares C, Goodwin M, Li Y, Liu CC, Kanekiyo T, ... ... Golde TE, et al. LRP1 is a neuronal receptor for α-synuclein uptake and spread. Molecular Neurodegeneration. 17: 57. PMID 36056345 DOI: 10.1186/s13024-022-00560-w  0.414
2022 Ibanez KR, McFarland KN, Phillips J, Allen M, Lessard CB, Zobel L, De La Cruz EG, Shah S, Vo Q, Wang X, Quicksall Z, Ryu D, Funk C, Ertekin-Taner N, Prokop S, ... Golde TE, et al. Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways. Alzheimer's Research & Therapy. 14: 104. PMID 35897046 DOI: 10.1186/s13195-022-01044-1  0.761
2022 Xia Y, Prokop S, Bell BM, Gorion KM, Croft CL, Nasif L, Xu G, Riffe CJ, Manaois AN, Strang KH, Quintin SS, Paterno G, Tansey MG, Borchelt DR, Golde TE, et al. Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. Communications Biology. 5: 446. PMID 35550593 DOI: 10.1038/s42003-022-03373-1  0.819
2022 Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, et al. Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. Free Neuropathology. 3. PMID 35494163 DOI: 10.17879/freeneuropathology-2022-3766  0.828
2022 Heath L, Earls JC, Magis AT, Kornilov SA, Lovejoy JC, Funk CC, Rappaport N, Logsdon BA, Mangravite LM, Kunkle BW, Martin ER, Naj AC, Ertekin-Taner N, Golde TE, Hood L, et al. Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Scientific Reports. 12: 6117. PMID 35413975 DOI: 10.1038/s41598-022-09825-2  0.532
2022 Marino M, Zhou L, Rincon MY, Callaerts-Vegh Z, Verhaert J, Wahis J, Creemers E, Yshii L, Wierda K, Saito T, Marneffe C, Voytyuk I, Wouters Y, Dewilde M, Duqué SI, ... ... Golde TE, et al. AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model. Embo Molecular Medicine. 14: e09824. PMID 35352880 DOI: 10.15252/emmm.201809824  0.325
2022 Aravindraja C, Sakthivel R, Liu X, Goodwin M, Veena P, Godovikova V, Fenno JC, Levites Y, Golde TE, Kesavalu L. Intracerebral but Not Peripheral Infection of Live Exacerbates Alzheimer's Disease Like Amyloid Pathology in APP-TgCRND8 Mice. International Journal of Molecular Sciences. 23. PMID 35328748 DOI: 10.3390/ijms23063328  0.375
2022 Golde TE. Alzheimer's disease - the journey of a healthy brain into organ failure. Molecular Neurodegeneration. 17: 18. PMID 35248124 DOI: 10.1186/s13024-022-00523-1  0.352
2022 Golde TE. Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 19: 209-227. PMID 35229269 DOI: 10.1007/s13311-022-01201-2  0.345
2022 Golde TE. Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 19: 209-227. PMID 35229269 DOI: 10.1007/s13311-022-01201-2  0.345
2022 Golde TE. Disease-Modifying Therapies for Alzheimer's Disease: More Questions than Answers. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 19: 209-227. PMID 35229269 DOI: 10.1007/s13311-022-01201-2  0.345
2021 Wang X, Allen M, İş Ö, Reddy JS, Tutor-New FQ, Castanedes Casey M, Carrasquillo MM, Oatman SR, Min Y, Asmann YW, Funk C, Nguyen T, Ho CC, Malphrus KG, Seyfried NT, ... ... Golde TE, et al. Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions. The Journal of Clinical Investigation. PMID 34813500 DOI: 10.1172/JCI149904  0.675
2021 McFarland KN, Ceballos C, Rosario A, Ladd T, Moore B, Golde G, Wang X, Allen M, Ertekin-Taner N, Funk CC, Robinson M, Baloni P, Rappaport N, Chakrabarty P, Golde TE. Microglia show differential transcriptomic response to Aβ peptide aggregates ex vivo and in vivo. Life Science Alliance. 4. PMID 34127518 DOI: 10.26508/lsa.202101108  0.588
2021 Levites Y, Funk C, Wang X, Chakrabarty P, McFarland KN, Bramblett B, O'Neal V, Liu X, Ladd T, Robinson M, Allen M, Carrasquillo MM, Dickson D, Cruz P, Ryu D, ... ... Golde TE, et al. Modulating innate immune activation states impacts the efficacy of specific Aβ immunotherapy. Molecular Neurodegeneration. 16: 32. PMID 33957936 DOI: 10.1186/s13024-021-00453-4  0.583
2021 Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G, Cruz PE, Lewis J, Giasson BI, Golde TE. Photodynamic studies reveal rapid formation and appreciable turnover of tau inclusions. Acta Neuropathologica. PMID 33496840 DOI: 10.1007/s00401-021-02264-9  0.745
2021 Li HD, Funk CC, McFarland K, Dammer EB, Allen M, Carrasquillo MM, Levties Y, Chakrabarty P, Burgess JD, Wang X, Dickson D, Seyfried NT, Duong DM, Lah JJ, Younkin SG, ... ... Golde TE, et al. Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33480174 DOI: 10.1002/alz.12254  0.683
2020 Barker W, Quinonez C, Greig MT, Behar R, Chirinos C, Rodriguez RA, Rosselli M, Rodriguez MJ, Cid RC, Rundek T, McFarland K, Hanson K, Smith G, DeKosky S, Vaillancourt D, ... ... Golde T, et al. Utility of Plasma Neurofilament Light in the 1Florida Alzheimer's Disease Research Center (ADRC). Journal of Alzheimer's Disease : Jad. PMID 33216030 DOI: 10.3233/JAD-200901  0.467
2020 Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, ... ... Golde TE, et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Jama Neurology. PMID 33074286 DOI: 10.1001/jamaneurol.2020.3536  0.511
2020 De Mena L, Smith MA, Martin J, Dunton KL, Ceballos-Diaz C, Jansen-West KR, Cruz PE, Dillon KD, Rincon-Limas DE, Golde TE, Moore BD, Levites Y. Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila. Alzheimer's Research & Therapy. 12: 132. PMID 33069251 DOI: 10.1186/s13195-020-00698-z  0.372
2020 Funk CC, Casella AM, Jung S, Richards MA, Rodriguez A, Shannon P, Donovan-Maiye R, Heavner B, Chard K, Xiao Y, Glusman G, Ertekin-Taner N, Golde TE, Toga A, Hood L, et al. Atlas of Transcription Factor Binding Sites from ENCODE DNase Hypersensitivity Data across 27 Tissue Types. Cell Reports. 32: 108029. PMID 32814038 DOI: 10.1016/J.Celrep.2020.108029  0.428
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Golde TE, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908  0.599
2020 Liu G, Fiock KL, Levites Y, Golde TE, Hefti MM, Lee G. Fyn depletion ameliorates tau-induced neuropathology. Acta Neuropathologica Communications. 8: 108. PMID 32665013 DOI: 10.1186/S40478-020-00979-6  0.375
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, ... ... Golde TE, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/S41591-020-0815-6  0.58
2020 Xu G, Fromholt SE, Chakrabarty P, Zhu F, Liu X, Pace MC, Koh J, Golde TE, Levites Y, Lewis J, Borchelt DR. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathologica Communications. 8: 43. PMID 32252825 DOI: 10.1186/S40478-020-00911-Y  0.415
2020 Goodwin MS, Croft CL, Futch HS, Ryu D, Ceballos-Diaz C, Liu X, Paterno G, Mejia C, Deng D, Menezes K, Londono L, Arjona K, Parianos M, Truong V, Rostonics E, ... ... Golde TE, et al. Utilizing minimally purified secreted rAAV for rapid and cost-effective manipulation of gene expression in the CNS. Molecular Neurodegeneration. 15: 15. PMID 32122372 DOI: 10.1186/S13024-020-00361-Z  0.675
2020 Koller EJ, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz PE, Ryu D, Golde TE, Sullivan PM, Lewis J, Borchelt DR, Chakrabarty P. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. Molecular Neurobiology. PMID 31903524 DOI: 10.1007/S12035-019-01859-4  0.383
2019 Croft CL, Futch HS, Moore BD, Golde TE. Organotypic brain slice cultures to model neurodegenerative proteinopathies. Molecular Neurodegeneration. 14: 45. PMID 31791377 DOI: 10.1186/S13024-019-0346-0  0.731
2019 Forner S, Martini AC, Prieto GA, Dang CT, Rodriguez-Ortiz CJ, Reyes-Ruiz JM, Trujillo-Estrada L, da Cunha C, Andrews EJ, Phan J, Vu Ha J, Chang AVZD, Levites Y, Cruz PE, Ager R, ... ... Golde T, et al. Intra- and extracellular β-amyloid overexpression via adeno-associated virus-mediated gene transfer impairs memory and synaptic plasticity in the hippocampus. Scientific Reports. 9: 15936. PMID 31685865 DOI: 10.1038/S41598-019-52324-0  0.453
2019 Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, ... ... Golde TE, et al. An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes. The Journal of Experimental Medicine. PMID 31467037 DOI: 10.1084/Jem.20190430  0.682
2019 Curiel Cid RE, Loewenstein DA, Rosselli M, Matias-Guiu JA, Piña D, Adjouadi M, Cabrerizo M, Bauer RM, Chan A, DeKosky ST, Golde T, Greig-Custo MT, Lizarraga G, Peñate A, Duara R. A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 550-559. PMID 31417955 DOI: 10.1016/J.Dadm.2019.05.003  0.331
2019 Koller EJ, De La Cruz EG, Machula T, Ibanez KR, Lin WL, Williams T, Riffe CJ, Ryu D, Strang KH, Liu X, Janus C, Golde TE, Dickson D, Giasson BI, Chakrabarty P. Combining P301L and S320F tau variants produces a novel accelerated model of tauopathy. Human Molecular Genetics. PMID 31261380 DOI: 10.1093/Hmg/Ddz151  0.351
2019 Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Reports. 27: 1345-1355.e6. PMID 31042463 DOI: 10.1016/J.Celrep.2019.03.087  0.382
2019 Duara R, Loewenstein DA, Lizarraga G, Adjouadi M, Barker WW, Greig-Custo MT, Rosselli M, Penate A, Shea YF, Behar R, Ollarves A, Robayo C, Hanson K, Marsiske M, Burke S, ... ... Golde T, et al. Effect of age, ethnicity, sex, cognitive status and APOE genotype on amyloid load and the threshold for amyloid positivity. Neuroimage. Clinical. 22: 101800. PMID 30991618 DOI: 10.1016/J.Nicl.2019.101800  0.572
2019 Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin WL, Deture M, Rodríguez-Lebrón E, Dickson DW, Chakrabarty P, Levites Y, Giasson BI, Golde TE. rAAV-based brain slice culture models of Alzheimer's and Parkinson's disease inclusion pathologies. The Journal of Experimental Medicine. PMID 30770411 DOI: 10.1084/Jem.20182184  0.755
2019 Strang KH, Golde TE, Giasson BI. MAPT mutations, tauopathy, and mechanisms of neurodegeneration. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30742061 DOI: 10.1038/S41374-019-0197-X  0.315
2019 Duara R, Loewenstein DA, Lizarraga G, Adjouadi M, Barker WW, Greig-Custo MT, Rosselli M, Curiel RE, Hanson K, Marsiske M, Ertekin-Taner N, Vaillancourt D, DeKosky S, de Santi S, Golde TE. P2-427: THE RELATIONSHIP BETWEEN HISPANIC ETHNICITY, AMYLOID LOAD AND APOE4 CARRIER STATUS Alzheimer's & Dementia. 15: P775-P776. DOI: 10.1016/J.Jalz.2019.06.2834  0.501
2018 Strang KH, Sorrentino ZA, Riffe CJ, Gorion KM, Vijayaraghavan N, Golde TE, Giasson BI. Phosphorylation of serine 305 in tau inhibits aggregation. Neuroscience Letters. 692: 187-192. PMID 30423399 DOI: 10.1016/J.Neulet.2018.11.011  0.302
2018 Lessard CB, Malnik SL, Zhou Y, Ladd TB, Cruz PE, Ran Y, Mahan TE, Chakrabaty P, Holtzman DM, Ulrich JD, Colonna M, Golde TE. High-affinity interactions and signal transduction between Aβ oligomers and TREM2. Embo Molecular Medicine. PMID 30341064 DOI: 10.15252/Emmm.201809027  0.499
2018 Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3  0.302
2018 Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, ... ... Golde TE, et al. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease. The Journal of Experimental Medicine. PMID 30158114 DOI: 10.1084/Jem.20180484  0.693
2018 Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, ... ... Golde TE, et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathologica. PMID 30136084 DOI: 10.1007/S00401-018-1900-5  0.646
2018 Croft CL, Moore BD, Ran Y, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Novel monoclonal antibodies targeting the microtubule-binding domain of human tau. Plos One. 13: e0195211. PMID 29608591 DOI: 10.1371/Journal.Pone.0195211  0.753
2018 Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. 293: 4579. PMID 29572329 DOI: 10.1074/jbc.AAC118.002657  0.728
2018 Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, et al. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimer's Research & Therapy. 10: 22. PMID 29458411 DOI: 10.1186/S13195-018-0349-Z  0.657
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Golde TE, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7  0.647
2017 Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE, Giasson BI. Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies. The Journal of Biological Chemistry. PMID 29259137 DOI: 10.1074/Jbc.M117.815357  0.757
2017 Moore BD, Martin J, de Mena L, Sanchez J, Cruz PE, Ceballos-Diaz C, Ladd TB, Ran Y, Levites Y, Kukar TL, Kurian JJ, McKenna R, Koo EH, Borchelt DR, Janus C, ... ... Golde TE, et al. Short Aβ peptides attenuate Aβ42 toxicity in vivo. The Journal of Experimental Medicine. PMID 29208777 DOI: 10.1084/Jem.20170600  0.73
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Golde TE, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1  0.648
2017 Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, ... ... Golde TE, et al. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29107053 DOI: 10.1016/J.Jalz.2017.09.012  0.677
2017 Strang KH, Goodwin MS, Riffe C, Moore BD, Chakrabarty P, Levites Y, Golde TE, Giasson BI. Generation and characterization of new monoclonal antibodies targeting the PHF1 and AT8 epitopes on human tau. Acta Neuropathologica Communications. 5: 58. PMID 28760159 DOI: 10.1186/S40478-017-0458-0  0.326
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Golde TE, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.628
2017 Futch HS, Croft CL, Truong VQ, Krause EG, Golde TE. Targeting psychologic stress signaling pathways in Alzheimer's disease. Molecular Neurodegeneration. 12: 49. PMID 28633663 DOI: 10.1186/S13024-017-0190-Z  0.753
2017 Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario AM, Golde TE, Li Q. Amyloid β peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice. Scientific Reports. 7: 3222. PMID 28607377 DOI: 10.1038/S41598-017-03397-2  0.389
2017 Loewenstein DA, Curiel RE, DeKosky S, Rosselli M, Bauer R, Grieg-Custo M, Penate A, Li C, Lizagarra G, Golde T, Adjouadi M, Duara R. Recovery from Proactive Semantic Interference and MRI Volume: A Replication and Extension Study. Journal of Alzheimer's Disease : Jad. PMID 28598850 DOI: 10.3233/Jad-170276  0.419
2017 McFarland NR, McFarland KN, Golde TE. Parkinson Disease and Autoimmune Disorders-What Can We Learn From Genome-wide Pleiotropy? Jama Neurology. PMID 28586798 DOI: 10.1001/Jamaneurol.2017.0843  0.558
2017 Croft CL, Cruz PE, Goodwin MS, Ceballos-Diaz C, Strang K, Chakrabarty P, Levites Y, Giasson BI, Golde TE. [P4-094]: TARGETING TAU AGGREGATION IN BRAIN SLICE CULTURE MODELS OF TAUOPATHIES Alzheimer's & Dementia. 13: P1294-P1294. DOI: 10.1016/J.Jalz.2017.06.1959  0.724
2016 Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, ... ... Golde TE, et al. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27939925 DOI: 10.1016/J.Jalz.2016.10.005  0.64
2016 Allen M, Carrasquillo MM, Funk C, Heavner BD, Zou F, Younkin CS, Burgess JD, Chai HS, Crook J, Eddy JA, Li H, Logsdon B, Peters MA, Dang KK, Wang X, ... ... Golde TE, et al. Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases. Scientific Data. 3: 160089. PMID 27727239 DOI: 10.1038/Sdata.2016.89  0.663
2016 Fernandez-Funez P, Sanchez-Garcia J, de Mena L, Zhang Y, Levites Y, Khare S, Golde TE, Rincon-Limas DE. Holdase activity of secreted Hsp70 masks amyloid-β42 neurotoxicity in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 27531960 DOI: 10.1073/Pnas.1608045113  0.36
2016 Park SA, Chevallier N, Tejwani K, Hung MM, Maruyama H, Golde TE, Koo EH. Deficiency in either COX-1 or COX-2 genes does not affect amyloid beta protein burden in amyloid precursor protein transgenic mice. Biochemical and Biophysical Research Communications. PMID 27425247 DOI: 10.1016/J.Bbrc.2016.07.015  0.41
2016 Golde TE. Alzheimer disease: Host immune defence, amyloid-β peptide and Alzheimer disease. Nature Reviews. Neurology. PMID 27418376 DOI: 10.1038/nrneurol.2016.105  0.316
2016 Golde TE. Overcoming translational barriers impeding development of Alzheimer's disease modifying therapies. Journal of Neurochemistry. PMID 27145445 DOI: 10.1111/jnc.13583  0.348
2016 Allen M, Burgess JD, Ballard T, Serie D, Wang X, Younkin CS, Sun Z, Kouri N, Baheti S, Wang C, Carrasquillo MM, Nguyen T, Lincoln S, Malphrus K, Murray M, ... Golde TE, et al. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. Acta Neuropathologica. PMID 27115769 DOI: 10.1007/S00401-016-1576-7  0.578
2016 DeKosky ST, Golde T. Cerebrospinal Biomarkers in Alzheimer Disease-Potential Roles as Markers of Prognosis and Neuroplasticity. Jama Neurology. PMID 27019279 DOI: 10.1001/Jamaneurol.2016.0090  0.446
2016 Golde TE, Ertekin-Taner N, Chakrabarty P, Allen M, Carrasquillo MM, Dickson DW, Younkin SG, Levites Y, Price ND, Funk C, Heavner BD, Logsdon B, Mangravite LM, Li H, Burgess JD, et al. F2-01-04: From Systems Level Transcriptomics to new Immune Targets for Alzheimer’s Disease Alzheimer's & Dementia. 12: P215-P216. DOI: 10.1016/J.Jalz.2016.06.383  0.572
2015 Xu G, Ran Y, Fromholt SE, Fu C, Yachnis AT, Golde TE, Borchelt DR. Murine Aβ over-production produces diffuse and compact Alzheimer-type amyloid deposits. Acta Neuropathologica Communications. 3: 72. PMID 26566997 DOI: 10.1186/S40478-015-0252-9  0.374
2015 Fernandez-Funez P, Zhang Y, Sanchez-Garcia J, de Mena L, Khare S, Golde TE, Levites Y, Rincon-Limas DE. Anti-Aβ single chain variable fragment antibodies exert synergistic neuroprotective activities in Drosophila models of Alzheimer's disease. Human Molecular Genetics. PMID 26253732 DOI: 10.1093/Hmg/Ddv321  0.338
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice. Molecular Neurodegeneration. 10: 25. PMID 26152284 DOI: 10.1186/S13024-015-0026-7  0.62
2015 Park HJ, Ran Y, Jung JI, Holmes O, Price AR, Smithson L, Ceballos-Diaz C, Han C, Wolfe MS, Daaka Y, Ryabinin AE, Kim SH, Hauger RL, Golde TE, Felsenstein KM. The stress response neuropeptide CRF increases amyloid-β production by regulating γ-secretase activity. The Embo Journal. 34: 1674-86. PMID 25964433 DOI: 10.15252/Embj.201488795  0.316
2015 Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, ... Golde TE, et al. A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6265-76. PMID 25904780 DOI: 10.1523/Jneurosci.5109-14.2015  0.391
2015 Ceballos-Diaz C, Rosario AM, Park HJ, Chakrabarty P, Sacino A, Cruz PE, Siemienski Z, Lara N, Moran C, Ravelo N, Golde TE, McFarland NR. Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice Molecular Neurodegeneration. DOI: 10.1186/s13024-015-0026-7  0.575
2015 Prasad T, Zhu P, Verma A, Chakrabarty P, Rosario AM, Golde TE, Li Q. 391. Increased Levels of Amyloid β Peptides in RPE via AAV-Mediated Gene Transfer Mimics AMD-Like Pathology in Mice Molecular Therapy. 23: S155. DOI: 10.1016/S1525-0016(16)34000-X  0.376
2015 Golde T, Levites Y, Cruz PE, Rosario AM, Chakrabarty P, Moran C, Liu X, Ceballos-Diaz C, Moore B, Price ND, Funk C. O1-11-03: Modulating chemokine signaling in preclinical Alzheimer's disease models Alzheimer's & Dementia. 11: P157-P157. DOI: 10.1016/J.Jalz.2015.07.089  0.344
2015 Moore B, Martin J, de Mena L, Sanchez J, Rincon-Limas DE, Fernandez-Funez P, Golde T. P1-084: Exploring the toxicity of short amyloid-beta peptides in vivo Alzheimer's & Dementia. 11: P371-P371. DOI: 10.1016/J.Jalz.2015.06.281  0.38
2014 Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3826-40. PMID 24623762 DOI: 10.1523/Jneurosci.5171-13.2014  0.369
2014 Jung JI, Ran Y, Cruz PE, Rosario AM, Ladd TB, Kukar TL, Koo EH, Felsenstein KM, Golde TE. Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry. 53: 1947-57. PMID 24620716 DOI: 10.1021/Bi401521T  0.713
2014 Golde TE. Open questions for Alzheimer's disease immunotherapy. Alzheimer's Research & Therapy. 6: 3. PMID 24393284 DOI: 10.1186/alzrt233  0.342
2014 Chakrabarty P, Tianbai L, Moore B, Rosario A, Cruz P, Ladd T, Ceballos-Diaz C, Golde T. P1-095: MODULATING INNATE IMMUNITY IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P336-P337. DOI: 10.1016/J.Jalz.2014.05.331  0.339
2013 Golde TE, Lewis J, McFarland NR. Anti-tau antibodies: hitting the target. Neuron. 80: 254-6. PMID 24139027 DOI: 10.1016/J.Neuron.2013.10.009  0.627
2013 Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, ... ... Golde TE, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/Jci69003  0.405
2013 Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L. γ-Secretase inhibitors and modulators. Biochimica Et Biophysica Acta. 1828: 2898-907. PMID 23791707 DOI: 10.1016/J.Bbamem.2013.06.005  0.359
2013 Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/J.Brainres.2013.06.006  0.321
2013 Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Steroids as γ-secretase modulators. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3775-85. PMID 23716494 DOI: 10.1096/Fj.12-225649  0.681
2013 Price AR, Xu G, Siemienski ZB, Smithson LA, Borchelt DR, Golde TE, Felsenstein KM. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-d. PMID 23704553 DOI: 10.1126/science.1234089  0.376
2013 Golde TE, Streit WJ, Chakrabarty P. Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimer's Research & Therapy. 5: 24. PMID 23692967 DOI: 10.1186/Alzrt178  0.327
2013 Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8  0.354
2013 Kim J, Chakrabarty P, Hanna A, March A, Dickson DW, Borchelt DR, Golde T, Janus C. Normal cognition in transgenic BRI2-Aβ mice. Molecular Neurodegeneration. 8: 15. PMID 23663320 DOI: 10.1186/1750-1326-8-15  0.651
2013 Melnikova T, Fromholt S, Kim H, Lee D, Xu G, Price A, Moore BD, Golde TE, Felsenstein KM, Savonenko A, Borchelt DR. Reversible pathologic and cognitive phenotypes in an inducible model of Alzheimer-amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3765-79. PMID 23447589 DOI: 10.1523/Jneurosci.4251-12.2013  0.337
2013 Chu J, Li JG, Ceballos-Diaz C, Golde T, Praticò D. The influence of 5-lipoxygenase on Alzheimer's disease-related tau pathology: in vivo and in vitro evidence. Biological Psychiatry. 74: 321-8. PMID 23352590 DOI: 10.1016/J.Biopsych.2012.12.012  0.486
2013 Golde TE, Felsenstein K, Chakrabarty P, Li A, Moore B, In JJ, Cruz P, Price A, Borchelt D, Janus C, Cebballos-Diaz C, Rosario A. Harnessing endogenous pathways and metabolites to treat or prevent neurodegenerative disease Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O36  0.318
2013 Blair L, Nordhues B, Hill S, Scaglione KM, O'Leary J, Breydo L, Bo Z, Li P, Wang L, Cotman C, Paulson H, Muschol M, Uversky V, Klengel T, Binder E, ... ... Golde T, et al. The Hsp90 co-chaperone FKBP51 produces neurotoxic tau oligomers: Implication for aging and Alzheimer's disease Alzheimers & Dementia. 9: 173. DOI: 10.1016/J.Jalz.2013.05.279  0.434
2013 Pratico D, Golde T, Chu J. P4-024: Involvement of 5lipoxygenase in Alzheimer's disease tau neuropathology Alzheimer's & Dementia. 9: P713-P713. DOI: 10.1016/J.Jalz.2013.05.1412  0.431
2013 Sahara N, Levites Y, Sinyavskiy G, Rosario A, Cruz P, Golde T. O2-08-04: Extracellular versus intracellular anti-tau immunotherapy effects in rTg4510 tau transgenic mice Alzheimer's & Dementia. 9: P330-P331. DOI: 10.1016/J.Jalz.2013.04.180  0.358
2012 Verbeeck C, Deng Q, Dejesus-Hernandez M, Taylor G, Ceballos-Diaz C, Kocerha J, Golde T, Das P, Rademakers R, Dickson DW, Kukar T. Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis. Molecular Neurodegeneration. 7: 53. PMID 23046583 DOI: 10.1186/1750-1326-7-53  0.687
2012 Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH. Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP). The Journal of Biological Chemistry. 287: 40629-40. PMID 23043097 DOI: 10.1074/jbc.M112.418442  0.387
2012 Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Praticò D. 5-Lipoxygenase gene transfer worsens memory, amyloid, and tau brain pathologies in a mouse model of Alzheimer disease. Annals of Neurology. 72: 442-54. PMID 23034916 DOI: 10.1002/ana.23642  0.408
2012 Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, et al. β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. Embo Molecular Medicine. 4: 980-91. PMID 22903875 DOI: 10.1002/Emmm.201101084  0.326
2012 Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H. Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11390-5. PMID 22895721 DOI: 10.1523/Jneurosci.0757-12.2012  0.352
2012 Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE. Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology. Molecular Neurodegeneration. 7: 39. PMID 22892055 DOI: 10.1186/1750-1326-7-39  0.678
2012 Chakrabarty P, Tianbai L, Herring A, Ceballos-Diaz C, Das P, Golde TE. Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition. Molecular Neurodegeneration. 7: 36. PMID 22838967 DOI: 10.1186/1750-1326-7-36  0.387
2012 Hanna A, Iremonger K, Das P, Dickson D, Golde T, Janus C. Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis. Alzheimer's Research & Therapy. 4: 21. PMID 22697412 DOI: 10.1186/Alzrt124  0.365
2012 Moore BD, Chakrabarty P, Levites Y, Kukar TL, Baine AM, Moroni T, Ladd TB, Das P, Dickson DW, Golde TE. Overlapping profiles of Aβ peptides in the Alzheimer's disease and pathological aging brains. Alzheimer's Research & Therapy. 4: 18. PMID 22621179 DOI: 10.1186/Alzrt121  0.714
2012 Galasko D, Golde T, Wilcock G. Recent Alzheimer's disease research highlights. Alzheimer's Research & Therapy. 4: 14. PMID 22594696 DOI: 10.1186/Alzrt117  0.447
2012 Golde TE, Ran Y, Felsenstein KM. Shifting a complex debate on γ-secretase cleavage and Alzheimer's disease. The Embo Journal. 31: 2237-9. PMID 22505028 DOI: 10.1038/Emboj.2012.111  0.379
2012 Chu J, Giannopoulos PF, Ceballos-Diaz C, Golde TE, Pratico D. Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice. Molecular Neurodegeneration. 7: 1. PMID 22222029 DOI: 10.1186/1750-1326-7-1  0.416
2012 Felsenstein K, Jung J, Ladd T, Price A, Moore B, Tang Y, Shapiro G, Hochhaus G, Golde T. O1-11-03: Endogenous cholesterol metabolites as potential Alzheimer's therapeutics Alzheimer's & Dementia. 8: P104-P105. DOI: 10.1016/J.Jalz.2012.05.265  0.319
2012 Park H, Shults C, Shyqyriu E, Vaziri S, Felsenstein K, Ceballos-Diaz C, Ladd T, Jung J, Kim S, Golde T. P4-003: Corticotropin-releasing hormone alters Aβ42 production via gamma-secretase Alzheimer's & Dementia. 8: P639-P639. DOI: 10.1016/J.Jalz.2012.05.1704  0.325
2011 Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. The Journal of Biological Chemistry. 286: 39794-803. PMID 21868380 DOI: 10.1074/Jbc.M111.277228  0.677
2011 Kukar TL, Ladd TB, Robertson P, Pintchovski SA, Moore B, Bann MA, Ren Z, Jansen-West K, Malphrus K, Eggert S, Maruyama H, Cottrell BA, Das P, Basi GS, Koo EH, ... Golde TE, et al. Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. The Journal of Biological Chemistry. 286: 39804-12. PMID 21868378 DOI: 10.1074/Jbc.M111.274696  0.732
2011 Chakrabarty P, Ceballos-Diaz C, Lin WL, Beccard A, Jansen-West K, McFarland NR, Janus C, Dickson D, Das P, Golde TE. Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification. Nature Neuroscience. 14: 694-6. PMID 21572432 DOI: 10.1038/Nn.2829  0.568
2011 Wang A, Das P, Switzer RC, Golde TE, Jankowsky JL. Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4124-36. PMID 21411653 DOI: 10.1523/JNEUROSCI.5077-10.2011  0.418
2011 Chakrabarty P, Herring A, Ceballos-Diaz C, Das P, Golde TE. Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo. Molecular Neurodegeneration. 6: 16. PMID 21324189 DOI: 10.1186/1750-1326-6-16  0.383
2011 Golde TE, Schneider LS, Koo EH. Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron. 69: 203-13. PMID 21262461 DOI: 10.1016/J.Neuron.2011.01.002  0.343
2011 Chakrabarty P, Ceballos-Diaz C, Beccard A, Cruz P, Dickson D, Das P, Golde T. P2-326: Towards a comprehensive analysis of the role of inflammatory mediators on Alzheimer's like pathology in pre-clinical mouse models Alzheimer's & Dementia. 7: S413-S414. DOI: 10.1016/J.Jalz.2011.05.1202  0.368
2010 Meckler X, Roseman J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, Thinakaran G. Reduced Alzheimer's disease ß-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16160-9. PMID 21123562 DOI: 10.1523/Jneurosci.4436-10.2010  0.376
2010 Chakrabarty P, Ceballos-Diaz C, Beccard A, Janus C, Dickson D, Golde TE, Das P. IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 184: 5333-43. PMID 20368278 DOI: 10.4049/Jimmunol.0903382  0.401
2010 De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218  0.393
2010 Chakrabarty P, Jansen-West K, Beccard A, Ceballos-Diaz C, Levites Y, Verbeeck C, Zubair AC, Dickson D, Golde TE, Das P. Massive gliosis induced by interleukin-6 suppresses Abeta deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 548-59. PMID 19825975 DOI: 10.1096/Fj.09-141754  0.413
2010 Golde TE, Petrucelli L, Lewis J. Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental Neurology. 223: 252-66. PMID 19716367 DOI: 10.1016/J.Expneurol.2009.07.035  0.45
2010 Wang A, Das P, Switzer RC, Golde TE, Jankowsky JL. O4-08-05: Robust Amyloid Clearance in a Mouse Model of AD Provides Novel Insights into the Mechanism of Abeta Immunotherapy Alzheimer's & Dementia. 6: e19-e19. DOI: 10.1016/j.jalz.2010.08.058  0.36
2010 Chakrabarty P, Beccard A, Cellallos-Diaz C, Golde T, Das P. P1-320: AAV-mediated expression of anti-inflammatory cytokines IL-10 and IL-4 significantly exacerbate amyloid pathology in the brains of APP TgCRND8 mice Alzheimer's & Dementia. 6: S266-S266. DOI: 10.1016/J.Jalz.2010.05.873  0.324
2010 Kukar T, Ladd T, Robertson P, Moore B, Jansen-West K, Eggert S, Koo E, Golde T. O2-03-01: Insight into the mechanism of gamma-secretase cleavage: Juxtamembrane amino acids are key to the length of secreted amyloid beta peptide Alzheimer's & Dementia. 6: S100-S100. DOI: 10.1016/J.Jalz.2010.05.314  0.692
2010 Abisambra JF, Blair LJ, Jones JR, Kraft C, Hill S, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Jansen-West K, Muschol M, Banko J, Golde T, Weeber EJ, et al. P3-425: Chaperone-mediated modulation of tau aggregation correlates with modifications in tau pathology and synaptic plasticity Alzheimer's & Dementia. 6: S577-S577. DOI: 10.1016/J.Jalz.2010.05.1968  0.367
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-2040. PMID 28178451 DOI: 10.1038/mt.2009.174  0.422
2009 Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 48: 10894-904. PMID 19821615 DOI: 10.1021/Bi901237K  0.711
2009 Donnelly A, Galasko D, Golde T, Mulvany F, Wilcock G. Welcome to Alzheimer's research & therapy. Alzheimer's Research & Therapy. 1: 1. PMID 19671199 DOI: 10.1186/Alzrt1  0.35
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: 10.1038/Mt.2009.174  0.35
2009 Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19  0.39
2009 Golde TE, Kukar TL. Medicine. Avoiding unintended toxicity. Science (New York, N.Y.). 324: 603-4. PMID 19407192 DOI: 10.1126/science.1174267  0.6
2009 McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiology of Disease. 34: 163-77. PMID 19320056 DOI: 10.1016/J.Nbd.2009.01.006  0.347
2009 Golde TE, Das P, Levites Y. Quantitative and mechanistic studies of Abeta immunotherapy. Cns & Neurological Disorders Drug Targets. 8: 31-49. PMID 19275635 DOI: 10.2174/187152709787601830  0.41
2008 Spilman P, Lessard P, Sattavat M, Bush C, Tousseyn T, Huang EJ, Giles K, Golde T, Das P, Fauq A, Prusiner SB, Dearmond SJ. A gamma-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains. Proceedings of the National Academy of Sciences of the United States of America. 105: 10595-600. PMID 18647832 DOI: 10.1073/Pnas.0803671105  0.361
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, ... ... Golde TE, et al. Substrate-targeting gamma-secretase modulators. Nature. 453: 925-9. PMID 18548070 DOI: 10.1038/Nature07055  0.806
2008 Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, ... ... Golde TE, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6030-6. PMID 18524908 DOI: 10.1523/Jneurosci.0891-08.2008  0.744
2008 Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. The Journal of Biological Chemistry. 283: 17049-54. PMID 18426795 DOI: 10.1074/Jbc.M802912200  0.722
2008 Buxbaum JN, Ye Z, Reixach N, Friske L, Levy C, Das P, Golde T, Masliah E, Roberts AR, Bartfai T. Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 2681-6. PMID 18272491 DOI: 10.1073/Pnas.0712197105  0.511
2008 Kukar T, Golde TE. Possible mechanisms of action of NSAIDs and related compounds that modulate gamma-secretase cleavage. Current Topics in Medicinal Chemistry. 8: 47-53. PMID 18220932 DOI: 10.2174/156802608783334042  0.716
2008 Golde TE. S2-02-05: Anti-abeta antibodies in Alzheimer's disease mouse models Alzheimer's & Dementia. 4: T125-T125. DOI: 10.1016/j.jalz.2008.05.280  0.302
2008 Zou F, Kim J, Miller VM, Levites Y, Ma L, Cangemi D, Bisceglio G, Younkin S, Pankratz VS, Petersen RC, Graff-Radford N, Dickson D, Rosenberry T, Golde T, Younkin SG. P3-276: BRI2 (ITM2B) shows genetic association with late-onset Alzheimer's disease Alzheimer's & Dementia. 4: T603-T603. DOI: 10.1016/J.Jalz.2008.05.1844  0.677
2008 Miller VM, Kim J, Zou F, Levites Y, Jansen-West K, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price R, Smithson L, Rangachari V, Sonoda L, Wagg K, ... ... Golde TE, et al. P2-347: BRI2 (ITM2B) inhibits Aβ deposition Alzheimer's & Dementia. 4: T474-T475. DOI: 10.1016/J.Jalz.2008.05.1424  0.661
2008 Kukar TL, Ladd TB, Bann MA, Fraering PC, Maharvi GM, Moore B, Rangachari V, Welzel A, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, ... ... Golde TE, et al. P2-338: Substrate-targeting gamma-secretase modulators Alzheimer's & Dementia. 4: T472-T472. DOI: 10.1016/J.Jalz.2008.05.1415  0.626
2008 Levites Y, Jansen K, Ceballos C, Golde TE. P2-303: Anti-amyloid single chain fragments as a tool to target Abeta deposition in APP mouse models Alzheimer's & Dementia. 4: T461-T461. DOI: 10.1016/J.Jalz.2008.05.1380  0.332
2007 Galasko DR, Graff-Radford N, May S, Hendrix S, Cottrell BA, Sagi SA, Mather G, Laughlin M, Zavitz KH, Swabb E, Golde TE, Murphy MP, Koo EH. Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Disease and Associated Disorders. 21: 292-9. PMID 18090435 DOI: 10.1097/Wad.0B013E31815D1048  0.38
2007 Kukar T, Prescott S, Eriksen JL, Holloway V, Murphy MP, Koo EH, Golde TE, Nicolle MM. Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. Bmc Neuroscience. 8: 54. PMID 17650315 DOI: 10.1186/1471-2202-8-54  0.81
2007 Ostrowski SM, Wilkinson BL, Golde TE, Landreth G. Statins reduce amyloid-beta production through inhibition of protein isoprenylation. The Journal of Biological Chemistry. 282: 26832-44. PMID 17646164 DOI: 10.1074/Jbc.M702640200  0.343
2007 Lawlor PA, Bland RJ, Das P, Price RW, Holloway V, Smithson L, Dicker BL, During MJ, Young D, Golde TE. Novel rat Alzheimer's disease models based on AAV-mediated gene transfer to selectively increase hippocampal Abeta levels. Molecular Neurodegeneration. 2: 11. PMID 17559680 DOI: 10.1186/1750-1326-2-11  0.405
2007 Kim J, Onstead L, Randle S, Price R, Smithson L, Zwizinski C, Dickson DW, Golde T, McGowan E. Abeta40 inhibits amyloid deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 627-33. PMID 17234594 DOI: 10.1523/Jneurosci.4849-06.2007  0.743
2007 Golde TE. The pathogenesis of Alzheimer's disease and the role of Abeta42. Cns Spectrums. 12: 4-6. PMID 17192766  0.377
2007 Ahmed RR, Murphy MP, Rochette MJ, Golde TE. Beta‐secretase regulation in aging and disease The Faseb Journal. 21. DOI: 10.1096/fasebj.21.5.a278-b  0.316
2007 Golde TE. Chapter 1 Amyloid and Amyloid-Like Protein Aggregates in Neurodegenerative Disease Blue Books of Neurology. 30: 1-32. DOI: 10.1016/S1877-184X(09)70052-8  0.375
2007 Kennedy GJ, Golde TE, Tariot PN, Cummings JL. Amyloid-based interventions in Alzheimer's disease Cns Spectrums. 12: 1-14.  0.313
2006 Golde TE, Dickson D, Hutton M. Filling the gaps in the abeta cascade hypothesis of Alzheimer's disease. Current Alzheimer Research. 3: 421-30. PMID 17168641 DOI: 10.2174/156720506779025189  0.443
2006 Levites Y, Jansen K, Smithson LA, Dakin R, Holloway VM, Das P, Golde TE. Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11923-8. PMID 17108166 DOI: 10.1523/Jneurosci.2795-06.2006  0.439
2006 Das P, Golde T. Dysfunction of TGF-beta signaling in Alzheimer's disease. The Journal of Clinical Investigation. 116: 2855-7. PMID 17080189 DOI: 10.1172/Jci30284  0.484
2006 Golde TE. Disease modifying therapy for AD? Journal of Neurochemistry. 99: 689-707. PMID 17076654 DOI: 10.1111/j.1471-4159.2006.04211.x  0.381
2006 Levites Y, Smithson LA, Price RW, Dakin RS, Yuan B, Sierks MR, Kim J, McGowan E, Reed DK, Rosenberry TL, Das P, Golde TE. Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2576-8. PMID 17068112 DOI: 10.1096/Fj.06-6463Fje  0.717
2006 Boeve BF, Baker M, Dickson DW, Parisi JE, Giannini C, Josephs KA, Hutton M, Pickering-Brown SM, Rademakers R, Tang-Wai D, Jack CR, Kantarci K, Shiung MM, Golde T, Smith GE, et al. Frontotemporal dementia and parkinsonism associated with the IVS1+1G->A mutation in progranulin: a clinicopathologic study. Brain : a Journal of Neurology. 129: 3103-14. PMID 17030535 DOI: 10.1093/Brain/Awl268  0.338
2006 Nyborg AC, Ladd TB, Jansen K, Kukar T, Golde TE. Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 1671-9. PMID 16873890 DOI: 10.1096/Fj.06-5762Com  0.637
2006 Murphy MP, Golde TE. Inclusion-body myositis and Alzheimer disease: two sides of the same coin, or different currencies altogether? Neurology. 66: S65-8. PMID 16432148 DOI: 10.1212/01.wnl.0000192108.02654.ac  0.422
2006 Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 116: 193-201. PMID 16341263 DOI: 10.1172/Jci25410  0.677
2006 Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. Journal of Neurochemistry. 96: 355-65. PMID 16300630 DOI: 10.1111/J.1471-4159.2005.03553.X  0.716
2006 Fowlkes KL, Mastrangelo MA, Narrow WC, Levites Y, Golde TE, Federoff HJ, Bowers WJ. 247. Devising Aβ-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery Molecular Therapy. 13: S94-S95. DOI: 10.1016/J.Ymthe.2006.08.274  0.375
2006 Duara R, Loewenstein DA, Lizarraga G, Adjouadi M, Barker WW, Greig-Custo MT, Penate A, Hanson K, Marsiske M, Burke SL, Ertekin-Taner N, Vaillancourt D, DeKosky S, de Santi S, Golde TE. P3-378: EFFECT OF AGE, GENDER, ETHNICITY, COGNITION AND APOE GENOTYPE ON AMYLOID LOAD AMONG NORMAL, MCI AND MILD DEMENTIA SUBJECTS USING [F-18] FLORBETABEN Alzheimer's & Dementia. 14: P1237-P1238. DOI: 10.1016/J.Jalz.2018.06.1740  0.485
2006 Kim J, Onstead L, Smithson L, Price R, Randle S, Yu C, Dickson D, Golde T, McGowan E. P1-113: The Abeta42/Abeta40 ratio, not total Abeta level, controls amyloid deposition in transgenic mice Alzheimer's & Dementia. 2: S128-S129. DOI: 10.1016/J.Jalz.2006.05.489  0.737
2006 Golde TE, Jansen KR, Nyborg AC, Das P, Chakrabarty P, Smithson LA, Kim J, Levties Y. P1-005: RAAV vectors to rapidly modify and model AD pathology in mice, rats, and guinea pigs Alzheimer's & Dementia. 2: S95-S95. DOI: 10.1016/J.Jalz.2006.05.380  0.554
2006 Janus C, Kim J, Hanna A, Wilson J, Price R, Dickson D, Golde T, McGowan E. O4-05-05: Dissociation between amyloid pathology and memory impairment Alzheimer's & Dementia. 2: S85-S86. DOI: 10.1016/J.Jalz.2006.05.331  0.665
2006 Kukar T, Ladd T, Bann M, Fraering P, Kache R, Fauq A, Wolfe M, Koo EH, Golde TE. P4-289: Mechanistic insights into the in vitro and in vivo modulation of Aβ42 levels and amyloid pathology by NSAIDS and related compounds Alzheimer's & Dementia. 2: S601-S602. DOI: 10.1016/J.Jalz.2006.05.2028  0.705
2006 Das P, Hrncic R, Golde T. P4-258: Heterologous amyloid vaccines induce a generic anti-amyloid response Alzheimer's & Dementia. 2: S592-S592. DOI: 10.1016/J.Jalz.2006.05.1997  0.355
2005 McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, ... ... Golde T, et al. Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron. 47: 191-9. PMID 16039562 DOI: 10.1016/J.Neuron.2005.06.030  0.829
2005 Kukar T, Murphy MP, Eriksen JL, Sagi SA, Weggen S, Smith TE, Ladd T, Khan MA, Kache R, Beard J, Dodson M, Merit S, Ozols VV, Anastasiadis PZ, Das P, ... ... Golde TE, et al. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nature Medicine. 11: 545-50. PMID 15834426 DOI: 10.1038/Nm1235  0.821
2005 Golde TE. The Abeta hypothesis: leading us to rationally-designed therapeutic strategies for the treatment or prevention of Alzheimer disease. Brain Pathology (Zurich, Switzerland). 15: 84-7. PMID 15779241  0.435
2004 Akbari Y, Hitt BD, Murphy MP, Dagher NN, Tseng BP, Green KN, Golde TE, LaFerla FM. Presenilin regulates capacitative calcium entry dependently and independently of gamma-secretase activity. Biochemical and Biophysical Research Communications. 322: 1145-52. PMID 15336962 DOI: 10.1016/J.Bbrc.2004.07.136  0.311
2004 Pickford F, Onstead-Cardinale L, Eriksen J, Murphy P, Pritam D, Kim J, Dolios G, Wang R, Dickson DW, Golde T, McGowan E. P2-090 ABETA42 is required for amyloid deposition in transgenic mice Neurobiology of Aging. 25: S249. DOI: 10.1016/S0197-4580(04)80837-6  0.767
2004 Golde TE, Eriksen J, Nicolle M, Murphy MP, Kukar T, Monnier T, Prescott S, Wright S, Chevallier N, Sagi S, Das P, Koo EH. O3-06-02 Selective Abeta42 modifying agents: effects on Abeta deposition and behavior in TG2576 mice Neurobiology of Aging. 25: S64. DOI: 10.1016/S0197-4580(04)80215-X  0.781
2003 Ramsden M, Nyborg AC, Murphy MP, Chang L, Stanczyk FZ, Golde TE, Pike CJ. Androgens modulate beta-amyloid levels in male rat brain. Journal of Neurochemistry. 87: 1052-5. PMID 14622134 DOI: 10.1046/J.1471-4159.2003.02114.X  0.483
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8532-8. PMID 13679422  0.511
2003 Martoglio B, Golde TE. Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs. Human Molecular Genetics. 12: R201-6. PMID 12966028 DOI: 10.1093/hmg/ddg303  0.331
2003 Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. The Journal of Clinical Investigation. 112: 440-9. PMID 12897211 DOI: 10.1172/Jci18162  0.711
2003 Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE, Kayed R, Metherate R, Mattson MP, Akbari Y, LaFerla FM. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron. 39: 409-21. PMID 12895417 DOI: 10.1016/S0896-6273(03)00434-3  0.533
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. The Journal of Biological Chemistry. 278: 31831-7. PMID 12805356 DOI: 10.1074/Jbc.M303592200  0.648
2003 Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. The Journal of Biological Chemistry. 278: 31825-30. PMID 12805355 DOI: 10.1074/Jbc.M303588200  0.657
2003 Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Golde TE, Koo EH. Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. The Journal of Biological Chemistry. 278: 30748-54. PMID 12777371 DOI: 10.1074/Jbc.M304824200  0.689
2003 Piper SC, Amtul Z, Galiñanes-Garcia L, Howard VG, Ziani-Cherif C, McLendon C, Rochette MJ, Fauq A, Golde TE, Murphy MP. Peptide-based, irreversible inhibitors of gamma-secretase activity. Biochemical and Biophysical Research Communications. 305: 529-33. PMID 12763025 DOI: 10.1016/S0006-291X(03)00828-3  0.407
2003 Murphy MP, Das P, Nyborg AC, Rochette MJ, Dodson MW, Loosbrock NM, Souder TM, McLendon C, Merit SL, Piper SC, Jansen KR, Golde TE. Overexpression of nicastrin increases Abeta production. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1138-40. PMID 12692078 DOI: 10.1096/fj.02-1050fje  0.478
2003 Golde TE. Alzheimer disease therapy: can the amyloid cascade be halted? The Journal of Clinical Investigation. 111: 11-8. PMID 12511580 DOI: 10.1172/JCI17527  0.333
2003 Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-β Immunization Effectively Reduces Amyloid Deposition in FcRγ-/-Knock-Out Mice The Journal of Neuroscience. 23: 8532-8538. DOI: 10.1523/Jneurosci.23-24-08532.2003  0.492
2002 Tang-Wai D, Lewis P, Boeve B, Hutton M, Golde T, Baker M, Hardy J, Michels V, Ivnik R, Jack C, Petersen R. Familial frontotemporal dementia associated with a novel presenilin-1 mutation. Dementia and Geriatric Cognitive Disorders. 14: 13-21. PMID 12053127 DOI: 10.1159/000058328  0.334
2002 Sugarman MC, Yamasaki TR, Oddo S, Echegoyen JC, Murphy MP, Golde TE, Jannatipour M, Leissring MA, LaFerla FM. Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. 99: 6334-9. PMID 11972038 DOI: 10.1073/Pnas.082545599  0.44
2002 Murphy MP, Uljon SN, Golde TE, Wang R. FAD-linked mutations in presenilin 1 alter the length of Abeta peptides derived from betaAPP transmembrane domain mutants. Biochimica Et Biophysica Acta. 1586: 199-209. PMID 11959461 DOI: 10.1016/S0925-4439(01)00098-9  0.474
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/Pnas.072033799  0.38
2002 Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of Disease. 9: 269-73. PMID 11895378 DOI: 10.1006/Nbdi.2001.0473  0.538
2002 Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of Disease. 9: 11-23. PMID 11848681 DOI: 10.1006/Nbdi.2001.0470  0.511
2002 Golde TE, Eriksen JL, Weggen S, Sagi SA, Koo EH. Nonsteroidal antiinflammatory drugs as therapeutic agents for Alzheimer's disease Drug Development Research. 56: 415-420. DOI: 10.1002/Ddr.10093  0.703
2001 McPhie DL, Golde T, Eckman CB, Yager D, Brant JB, Neve RL. beta-Secretase cleavage of the amyloid precursor protein mediates neuronal apoptosis caused by familial Alzheimer's disease mutations. Brain Research. Molecular Brain Research. 97: 103-13. PMID 11744168 DOI: 10.1016/S0169-328X(01)00294-7  0.408
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  0.642
2001 Weggen S, Eriksen JL, Das P, Sagi SA, Wang R, Pietrzik CU, Findlay KA, Smith TE, Murphy MP, Bulter T, Kang DE, Marquez-Sterling N, Golde TE, Koo EH. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature. 414: 212-6. PMID 11700559 DOI: 10.1038/35102591  0.748
2001 Ni CY, Murphy MP, Golde TE, Carpenter G. gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science (New York, N.Y.). 294: 2179-81. PMID 11679632 DOI: 10.1126/Science.1065412  0.317
2001 Golde TE, Eckman CB. Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease. Drug Discovery Today. 6: 1049-1055. PMID 11590033 DOI: 10.1016/S1359-6446(01)01965-1  0.401
2001 Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B. Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion. The Journal of Biological Chemistry. 276: 38563-9. PMID 11504726 DOI: 10.1074/Jbc.M105376200  0.357
2001 Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG, Eckman CB. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). Journal of Neuroscience Methods. 108: 171-9. PMID 11478976 DOI: 10.1016/S0165-0270(01)00388-0  0.586
2001 Lewis PA, Piper S, Baker M, Onstead L, Murphy MP, Hardy J, Wang R, McGowan E, Golde TE. Expression of BRI-amyloid beta peptide fusion proteins: a novel method for specific high-level expression of amyloid beta peptides. Biochimica Et Biophysica Acta. 1537: 58-62. PMID 11476963 DOI: 10.1016/S0925-4439(01)00054-0  0.654
2001 Mudher A, Chapman S, Richardson J, Asuni A, Gibb G, Pollard C, Killick R, Iqbal T, Raymond L, Varndell I, Sheppard P, Makoff A, Gower E, Soden PE, Lewis P, ... ... Golde TE, et al. Dishevelled regulates the metabolism of amyloid precursor protein via protein kinase C/mitogen-activated protein kinase and c-Jun terminal kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 4987-95. PMID 11438574 DOI: 10.1523/Jneurosci.21-14-04987.2001  0.417
2001 Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends in Molecular Medicine. 7: 264-9. PMID 11378516 DOI: 10.1016/S1471-4914(01)02064-0  0.617
2001 Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, et al. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 16-18. PMID 11099491 DOI: 10.1096/Fj.00-0528Fje  0.621
2001 Pinnix I, Musunuru U, Tun H, Sridharan A, Golde T, Eckman C, Ziani-Cherif C, Onstead L, Sambamurti K. A novel gamma -secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. The Journal of Biological Chemistry. 276: 481-7. PMID 11035007 DOI: 10.1074/Jbc.M005968200  0.366
2000 Murphy MP, Wang R, Fraser PE, Fauq A, Golde TE. An empirical model of gamma-secretase activity. Annals of the New York Academy of Sciences. 920: 233-40. PMID 11193156 DOI: 10.1111/J.1749-6632.2000.Tb06928.X  0.452
2000 Houlden H, Baker M, McGowan E, Lewis P, Hutton M, Crook R, Wood NW, Kumar-Singh S, Geddes J, Swash M, Scaravilli F, Holton JL, Lashley T, Tomita T, Hashimoto T, ... ... Golde T, et al. Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Annals of Neurology. 48: 806-8. PMID 11079548 DOI: 10.1002/1531-8249(200011)48:5<806::Aid-Ana18>3.0.Co;2-F  0.635
2000 McLendon C, Xin T, Ziani-Cherif C, Murphy MP, Findlay KA, Lewis PA, Pinnix I, Sambamurti K, Wang R, Fauq A, Golde TE. Cell-free assays for gamma-secretase activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 14: 2383-6. PMID 11024004 DOI: 10.1096/Fj.00-0286Fje  0.502
2000 Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochimica Et Biophysica Acta. 1502: 172-87. PMID 10899442 DOI: 10.1016/S0925-4439(00)00043-0  0.62
2000 Murphy MP, Uljon SN, Fraser PE, Fauq A, Lookingbill HA, Findlay KA, Smith TE, Lewis PA, McLendon DC, Wang R, Golde TE. Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage. The Journal of Biological Chemistry. 275: 26277-84. PMID 10816583 DOI: 10.1074/Jbc.M002812200  0.473
2000 Golde TE, Findlay KA, Smith TE, Thompson S, McLendon DC, Wang R, Murphy MP. Presenilns regulators of γ-secretase cleavage Neurobiology of Aging. 21: 67. DOI: 10.1016/S0197-4580(00)82523-3  0.325
2000 Lewis PA, McGowan E, Hardy JA, Golde TE. Specific production of Aß peptides from BRI-Aß fusion proteins Neurobiology of Aging. 21: 199. DOI: 10.1016/S0197-4580(00)82238-1  0.465
2000 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Aβ42 deposition is selectively altered in brains of Aβ1–42 immunized TG2576 mice Neurobiology of Aging. 21: 152-153. DOI: 10.1016/S0197-4580(00)82023-0  0.586
1999 Murphy MP, Hickman LJ, Eckman CB, Uljon SN, Wang R, Golde TE. gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length. The Journal of Biological Chemistry. 274: 11914-23. PMID 10207012 DOI: 10.1074/Jbc.274.17.11914  0.495
1994 Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Eckman C, Golde TE, Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (New York, N.Y.). 264: 1336-40. PMID 8191290 DOI: 10.1126/Science.8191290  0.486
1994 Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG. Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. Annals of Neurology. 36: 903-11. PMID 7998778 DOI: 10.1002/Ana.410360616  0.539
1994 Cheung TT, Ghiso J, Shojif M, Cai X, Golde T, Gandy S, Frangione B, Younkin S. Characterization by radiosequencing of the carboxyl-terminal derivatives produced from normal and mutant amyloid β protein precursors Amyloid. 1: 30-38. DOI: 10.3109/13506129409148622  0.573
1993 Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science (New York, N.Y.). 259: 514-6. PMID 8424174 DOI: 10.1126/Science.8424174  0.504
1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 9513-7. PMID 8415732 DOI: 10.1073/Pnas.90.20.9513  0.549
1993 Kalaria RN, Golde T, Kroon SN, Perry G. Serine protease inhibitor antithrombin III and its messenger RNA in the pathogenesis of Alzheimer's disease. The American Journal of Pathology. 143: 886-93. PMID 8362984  0.361
1993 Golde TE, Cai XD, Shoji M, Younkin SG. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 103-8. PMID 8239266 DOI: 10.1111/J.1749-6632.1993.Tb23036.X  0.499
1992 Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847 DOI: 10.1126/Science.1738847  0.485
1992 Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science (New York, N.Y.). 255: 726-8. PMID 1738846 DOI: 10.1126/Science.1738846  0.307
1992 Gillespie SL, Golde TE, Younkin SG. Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochemical and Biophysical Research Communications. 187: 1285-90. PMID 1417805 DOI: 10.1016/0006-291X(92)90442-N  0.511
1992 Estus S, Golde TE, Younkin SG. Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives. Annals of the New York Academy of Sciences. 674: 138-48. PMID 1288359 DOI: 10.1111/J.1749-6632.1992.Tb27483.X  0.563
1991 Kalaria RN, Golde TE, Cohen ML, Younkin SG. Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier. Annals of the New York Academy of Sciences. 640: 145-8. PMID 1776732 DOI: 10.1111/J.1749-6632.1991.Tb00206.X  0.631
1990 Golde TE, Estus S, Usiak M, Younkin LH, Younkin SG. Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron. 4: 253-67. PMID 2106330 DOI: 10.1016/0896-6273(90)90100-T  0.507
1990 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. Analysis of the beta-amyloid protein precursor of Alzheimer's disease: mRNAs and protein products. Advances in Neurology. 51: 181-4. PMID 2104687  0.624
1989 Palmert MR, Podlisny MB, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Whitehouse PJ, Witker DS, Oltersdorf T. The beta amyloid protein precursor: mRNAs, membrane-associated forms, and soluble derivatives. Progress in Clinical and Biological Research. 317: 971-84. PMID 2513588  0.621
1989 Golde TE, Younkin SG. CONSTRUCTION OF RETROVIRAL VECTORS DESIGNED TO INCREASE EXPRESSION OF THE β AMYLOID PROTEIN AND ITS PRECURSOR Journal of Neuropathology and Experimental Neurology. 48: 341. DOI: 10.1097/00005072-198905000-00128  0.475
1988 Cohen ML, Golde TE, Usiak MF, Younkin LH, Younkin SG. In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 85: 1227-31. PMID 3277188 DOI: 10.1073/Pnas.85.4.1227  0.658
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  0.742
1988 PALMERT MR, GOLDE TE, COHEN ML, KOVACS DM, TANZI RE, GUSELLA JF, USIAK MF, YOUNKIN LH, YOUNKIN SG. AMYLOID PROTEIN PRECURSOR mRNA LACKING THE KUNITZ PROTEASE INHIBITOR SEQUENCE INCREASES IN AD NUCLEUS BASALIS AND LOCUS CERULEUS NEURONS Alzheimer Disease & Associated Disorders. 2: 401. DOI: 10.1097/00002093-198802040-00031  0.725
1987 Cohen M, Golde T, Usiak M, Younkin S. IN SITU HYBRIDIZATION IN HUMAN NUCLEUS BASALIS OF MEYNERT Journal of Neuropathology and Experimental Neurology. 46: 365. DOI: 10.1097/00005072-198705000-00106  0.494
Low-probability matches (unlikely to be authored by this person)
2020 Itzhaki RF, Golde TE, Heneka MT, Readhead B. Do infections have a role in the pathogenesis of Alzheimer disease? Nature Reviews. Neurology. PMID 32152461 DOI: 10.1038/S41582-020-0323-9  0.296
2011 Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. Plos One. 6: e27221. PMID 22174738 DOI: 10.1371/Journal.Pone.0027221  0.295
2002 Golde TE. Inflammation takes on Alzheimer disease. Nature Medicine. 8: 936-8. PMID 12205453 DOI: 10.1038/nm0902-936  0.29
1993 Cal X, Golde TE, Cheung TT, Younkin SG. EXCESS AMYLOID ß PROTEIN IS RELEASED FROM A MUTANT AMYLOID ß PROTEIN PRECURSOR LINKED TO FAMILIAL ALZHEIMERʼS DISEASE Journal of Neuropathology and Experimental Neurology. 52: 334. DOI: 10.1097/00005072-199305000-00295  0.289
2015 Chakrabarty P, Hudson Iii VJ, Sacino AN, Brooks MM, D'Alton S, Lewis J, Golde TE, Giasson BI. Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission. Acta Neuropathologica. 130: 303-5. PMID 25982997 DOI: 10.1007/S00401-015-1444-X  0.289
2013 Sacino AN, Brooks M, McGarvey NH, McKinney AB, Thomas MA, Levites Y, Ran Y, Golde TE, Giasson BI. Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein. Acta Neuropathologica Communications. 1: 38. PMID 24252149 DOI: 10.1186/2051-5960-1-38  0.287
2005 Golde TE, Janus C. Homing in on intracellular Abeta? Neuron. 45: 639-42. PMID 15748837 DOI: 10.1016/J.Neuron.2005.02.013  0.285
1992 Shoji M, Golde TE, Ghiso J, Cheung TT, Estus S, Shaffer LM, Cai XD, McKay DM, Tintner R, Frangione B. Production of the Alzheimer amyloid beta protein by normal proteolytic processing. Science (New York, N.Y.). 258: 126-9. PMID 1439760  0.285
2015 Golde T. F5-03-02: Developing a more robust therapeutic discovery pipeline for neurodegenerative disease Alzheimer's & Dementia. 11: P306-P306. DOI: 10.1016/J.Jalz.2015.07.432  0.283
2011 Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization. Plos One. 6: e27019. PMID 22069482 DOI: 10.1371/Journal.Pone.0027019  0.282
2023 Weber DM, Taylor SW, Lagier RJ, Kim JC, Goldman SM, Clarke NJ, Vaillancourt DE, Duara R, McFarland KN, Wang WE, Golde TE, Racke MK. Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer's disease assessment. Medrxiv : the Preprint Server For Health Sciences. PMID 38168329 DOI: 10.1101/2023.12.12.23299878  0.28
2018 Loewenstein DA, Curiel RE, DeKosky S, Bauer RM, Rosselli M, Guinjoan SM, Adjouadi M, Peñate A, Barker WW, Goenaga S, Golde T, Greig-Custo MT, Hanson KS, Li C, Lizarraga G, et al. Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment. Neurology. PMID 30076274 DOI: 10.1212/Wnl.0000000000006128  0.279
2005 Golde TE, Bacskai BJ. Bringing amyloid into focus. Nature Biotechnology. 23: 552-4. PMID 15877070 DOI: 10.1038/Nbt0505-552  0.277
2020 Goodwin MS, Sinyavskaya O, Burg F, O'Neal V, Ceballos-Diaz C, Cruz PE, Lewis J, Giasson BI, Davies P, Golde TE, Levites Y. Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33128896 DOI: 10.1016/j.ymthe.2020.10.007  0.276
2018 Hossain F, Sorrentino C, Bilyeu AU, Matossian M, Crabtree J, Pannuti A, Burow M, Golde T, Osborne B, Miele L. Abstract P6-07-06: Targeting cancer stem-like cells metabolism via non-canonical notch signaling pathways in triple negative breast cancer Cancer Research. 78. DOI: 10.1158/1538-7445.Sabcs17-P6-07-06  0.276
2014 Jung JI, Premraj S, Cruz PE, Ladd TB, Kwak Y, Koo EH, Felsenstein KM, Golde TE, Ran Y. Independent relationship between amyloid precursor protein (APP) dimerization and γ-secretase processivity. Plos One. 9: e111553. PMID 25350374 DOI: 10.1371/Journal.Pone.0111553  0.275
2015 Levites Y, Golde T, Cruz PE, Rosario AM, Sinyavskiy GD. O3-04-06: Functionalized intrabodies as potential tau targeting therapy Alzheimer's & Dementia. 11: P227-P227. DOI: 10.1016/J.Jalz.2015.07.259  0.273
2007 Golde T. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 406.  0.272
2012 Cao L, Schrank BR, Rodriguez S, Benz EG, Moulia TW, Rickenbacher GT, Gomez AC, Levites Y, Edwards SR, Golde TE, Hyman BT, Barnea G, Albers MW. Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature Communications. 3: 1009. PMID 22910355 DOI: 10.1038/Ncomms2013  0.269
2011 Levites Y, Jansen K, Ceballos-Diaz C, Cruz P, Adekar S, Dessain S, Golde T. P2-473: Novel methods to develop human monoclonal anti-amyloid antibodies that target Aβ aggregates Alzheimer's & Dementia. 7: S464-S464. DOI: 10.1016/J.Jalz.2011.05.1345  0.268
2014 Janus C, Golde T. The effect of brief neonatal cryoanesthesia on physical development and adult cognitive function in mice. Behavioural Brain Research. 259: 253-60. PMID 24239696 DOI: 10.1016/J.Bbr.2013.11.010  0.267
2013 Felsenstein K, Jung J, Ladd T, Ran Y, Price A, Galasko D, Koo E, Shapiro G, Tang Y, Hochhaus G, Golde T. S1-01-04: Cholesterol metabolites as endogenous gamma-secretase modulators Alzheimer's & Dementia. 9: P121-P122. DOI: 10.1016/J.Jalz.2013.04.035  0.266
2015 Chakrabarty P, Brooks M, Hudson V, Levites Y, Giasson BI, Golde T. O2-05-01: IL-10 modifies disease progression and pathology in a mouse model of alpha synucleinopathy Alzheimer's & Dementia. 11: P182-P183. DOI: 10.1016/J.Jalz.2015.07.154  0.266
2015 Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP). Plos One. 10: e0144758. PMID 26678856 DOI: 10.1371/Journal.Pone.0144758  0.266
2019 Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells. The Journal of Biological Chemistry. PMID 31167792 DOI: 10.1074/Jbc.Ra119.008041  0.265
2013 Galasko D, Golde TE, Scheltens P. Progress in Alzheimer's disease research circa 2013: Is the glass half empty or half full? Alzheimer's Research & Therapy. 5: 26. PMID 23731836 DOI: 10.1186/Alzrt180  0.264
2017 Hossain F, Sorrentino C, Bilyeu A, Crabtree J, Pannuti A, Golde T, Osborne B, Miele L. Abstract 2904: Targeting cancer stem-like cells in triple negative breast cancer cells through non-canonical notch signaling Cancer Research. 77: 2904-2904. DOI: 10.1158/1538-7445.Am2017-2904  0.263
2015 Chakrabarty P, Li A, Ceballos-Diaz C, Eddy JA, Funk CC, Moore B, DiNunno N, Rosario AM, Cruz PE, Verbeeck C, Sacino A, Nix S, Janus C, Price ND, Das P, ... Golde TE, et al. IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior. Neuron. 85: 519-33. PMID 25619653 DOI: 10.1016/J.Neuron.2014.11.020  0.263
2010 Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, et al. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15374-82. PMID 21084594 DOI: 10.1523/Jneurosci.3155-10.2010  0.26
2009 Golde TE, Miller VM. Proteinopathy-induced neuronal senescence: a hypothesis for brain failure in Alzheimer's and other neurodegenerative diseases. Alzheimer's Research & Therapy. 1: 5. PMID 19822029 DOI: 10.1186/alzrt5  0.258
2015 Yun J, Espinoza I, Pannuti A, Romero D, Martinez L, Caskey M, Stanculescu A, Bocchetta M, Rizzo P, Band V, Band H, Kim HM, Park SK, Kang KW, Avantaggiati ML, ... ... Golde T, et al. p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating with the Notch Transcriptional Complex via MAML1. Journal of Cellular Physiology. PMID 26033683 DOI: 10.1002/Jcp.25052  0.257
2013 Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/Jci66029  0.257
2018 Hossain F, Bilyeu ADU, Sorrentino C, Crabtree J, Pannuti A, Matossian M, Burow M, Golde T, Osborne B, Miele L. Abstract 157: Targeting cancer stem-like cells in triple negative breast cancer Cancer Research. 78: 157-157. DOI: 10.1158/1538-7445.Am2018-157  0.255
2006 Nguyen JH, Yamamoto S, Steers J, Sevlever D, Lin W, Shimojima N, Castanedes-Casey M, Genco P, Golde T, Richelson E, Dickson D, McKinney M, Eckman CB. Matrix metalloproteinase-9 contributes to brain extravasation and edema in fulminant hepatic failure mice. Journal of Hepatology. 44: 1105-14. PMID 16458990 DOI: 10.1016/J.Jhep.2005.09.019  0.255
2019 Hossain F, Ucar D, Majumder S, Xu K, Ran Y, Minter L, Xi Y, Burow M, Golde T, Osborne B, Miele L. Abstract P6-22-01: Repurposing sulindac sulfide as a notch inhibitor to target cancer stem-like cells in triple negative breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-P6-22-01  0.254
2019 Colon-Perez LM, Ibanez KR, Suarez M, Torroella K, Acuna K, Ofori E, Levites Y, Vaillancourt DE, Golde TE, Chakrabarty P, Febo M. Neurite orientation dispersion and density imaging reveals white matter and hippocampal microstructure changes produced by Interleukin-6 in the TgCRND8 mouse model of amyloidosis. Neuroimage. 202: 116138. PMID 31472250 DOI: 10.1016/J.Neuroimage.2019.116138  0.253
2006 Das P, Smithson LA, Price RW, Holloway VM, Levites Y, Chakrabarty P, Golde TE. Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Abeta immunotherapy. Journal of Neuroinflammation. 3: 17. PMID 16872492 DOI: 10.1186/1742-2094-3-17  0.25
2011 Golde TE, Lamb BT, Galasko D. Right sizing funding for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 17. PMID 21554753 DOI: 10.1186/Alzrt76  0.25
2012 Liu Y, Zhang W, Li L, Salvador LA, Chen T, Chen W, Felsenstein KM, Ladd TB, Price AR, Golde TE, He J, Xu Y, Li Y, Luesch H. Cyanobacterial peptides as a prototype for the design of potent β-secretase inhibitors and the development of selective chemical probes for other aspartic proteases. Journal of Medicinal Chemistry. 55: 10749-65. PMID 23181502 DOI: 10.1021/Jm301630S  0.249
2006 Nyborg AC, Ladd TB, Zwizinski CW, Lah JJ, Golde TE. Sortilin, SorCS1b, and SorLA Vps10p sorting receptors, are novel gamma-secretase substrates. Molecular Neurodegeneration. 1: 3. PMID 16930450 DOI: 10.1186/1750-1326-1-3  0.247
2009 Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 7607-12. PMID 19383787 DOI: 10.1073/Pnas.0900688106  0.245
2000 Lewis PA, Perez-Tur J, Golde TE, Hardy J. The presenilin 1 C92S mutation increases abeta 42 production. Biochemical and Biophysical Research Communications. 277: 261-3. PMID 11027672 DOI: 10.1006/Bbrc.2000.3646  0.244
2014 Ran Y, Cruz PE, Ladd TB, Fauq AH, Jung JI, Matthews J, Felsenstein KM, Golde TE. γ-Secretase processing and effects of γ-secretase inhibitors and modulators on long Aβ peptides in cells. The Journal of Biological Chemistry. 289: 3276-87. PMID 24352661 DOI: 10.1074/Jbc.M113.512921  0.244
2020 Hossain F, Ucar DA, Majumder S, Matossian M, Monticone G, Xu K, Ran Y, Minter L, Xi Y, Burow M, Golde T, Osborne B, Miele L. Abstract P5-04-19: Sulindac sulfide as a non-immune suppressive gamma secretase modifier to target triple negative breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs19-P5-04-19  0.243
2006 Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of Neurochemistry. 96: 218-27. PMID 16305624 DOI: 10.1111/J.1471-4159.2005.03548.X  0.243
2006 Miele L, Golde T, Osborne B. Notch signaling in cancer. Current Molecular Medicine. 6: 905-18. PMID 17168741 DOI: 10.2174/156652406779010830  0.242
2006 Nyborg AC, Levites Y, Ladd TB, Zwizinski CW, Jansen K, Golde TE. O3-03-03: Sortilin, SorLA, SorCS1: Just novel gamma-secretase substrates or more intimately involved in AD pathogenesis? Alzheimer's & Dementia. 2: S57-S57. DOI: 10.1016/J.Jalz.2006.05.207  0.242
2016 Moore BD, Martin J, de Mena L, Levites Y, Ceballos-Diaz C, Cruz PE, Janus C, Rincon-Limas DE, Fernandez-Funez P, Golde TE. P1-165: Evidence to Support γ-Secretase Modulators: Short Aβ Peptides are Protective in Vivo Alzheimer's & Dementia. 12: P466-P466. DOI: 10.1016/J.Jalz.2016.06.913  0.241
2018 Hamm M, Ladd TB, Levites Y, Golde TE, Giasson BI, Lewis J. Designing antibodies against LRRK2-targeted tau epitopes. Plos One. 13: e0204367. PMID 30261006 DOI: 10.1371/Journal.Pone.0204367  0.241
2020 Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y. γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not. Alzheimer's Research & Therapy. 12: 61. PMID 32430033 DOI: 10.1186/S13195-020-00622-5  0.236
2010 Golde TE. PL-02-03: Obstacles to translating preclinical advances into successful therapies for Alzheimer's disease Alzheimer's & Dementia. 6: S86-S86. DOI: 10.1016/j.jalz.2010.05.260  0.235
2019 Hossain F, Ucar DA, Majumder S, Matossian M, Xu K, Ran Y, Minter L, Xi Y, Burow M, Golde T, Osborne B, Miele L. Abstract 3439: Sulindac sulfide as a gamma secretase modifier to target triple negative breast cancer Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3439  0.232
2019 X Cai L, Tanada Y, D Bello G, C Fleming J, F Alkassis F, Ladd T, Golde T, Koh J, Chen S, Kasahara H. Cardiac MLC2 kinase is localized to the Z-disc and interacts with α-actinin2. Scientific Reports. 9: 12580. PMID 31467300 DOI: 10.1038/S41598-019-48884-W  0.232
2018 Dawson TM, Golde TE, Lagier-Tourenne C. Animal models of neurodegenerative diseases. Nature Neuroscience. 21: 1370-1379. PMID 30250265 DOI: 10.1038/S41593-018-0236-8  0.23
2013 Galasko D, Golde TE. Biomarkers for Alzheimer's disease in plasma, serum and blood - conceptual and practical problems. Alzheimer's Research & Therapy. 5: 10. PMID 23470193 DOI: 10.1186/alzrt164  0.229
2009 Grudzien P, Strack P, Golde T, Miele L, Foreman K. Inhibition of Notch signaling reduces the stem-like cell population in T47D breast cancer cells and prevents mammosphere formation. Cancer Research. 69: 106. DOI: 10.1158/0008-5472.Sabcs-106  0.227
2022 Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (part 2): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases. Molecular Neurodegeneration. 17: 69. PMID 36316783 DOI: 10.1186/s13024-022-00571-7  0.226
2022 Rossi SL, Subramanian P, Bu G, Di Polo A, Golde TE, Bovenkamp DE. Common features of neurodegenerative disease: exploring the brain-eye connection and beyond (Part 1): the 2021 pre-symposium of the 15th international conference on Alzheimer's and Parkinson's diseases. Molecular Neurodegeneration. 17: 68. PMID 36310167 DOI: 10.1186/s13024-022-00570-8  0.226
2016 Rosario AM, Cruz PE, Ceballos-Diaz C, Strickland MR, Siemienski Z, Pardo M, Schob KL, Li A, Aslanidi GV, Srivastava A, Golde TE, Chakrabarty P. Microglia-specific targeting by novel capsid-modified AAV6 vectors. Molecular Therapy. Methods & Clinical Development. 3: 16026. PMID 27308302 DOI: 10.1038/Mtm.2016.26  0.226
2006 Futch HS, Kuhn MZ, Levites Y, Moore BD, Janus C, Golde TE. P2-063: A NOVEL IMMUNOTHERAPEUTIC APPROACH TO SIMULTANEOUSLY TARGET BEHAVIORAL STRESS AND DOWNSTREAM PATHOLOGIES IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P690-P691. DOI: 10.1016/J.Jalz.2018.06.748  0.225
2003 Das P, Chapoval S, Howard V, David CS, Golde TE. Immune responses against Abeta1-42 in HLA class II transgenic mice: implications for Abeta1-42 immune-mediated therapies. Neurobiology of Aging. 24: 969-76. PMID 12928057 DOI: 10.1016/S0197-4580(03)00036-8  0.22
2006 Levites Y, Das P, Smithson LA, Golde TE. P4-291: Anti-Abeta immunotherapy: Quantitative evaluation of acute effects in young TG2576 mice Alzheimer's & Dementia. 2: S602-S602. DOI: 10.1016/J.Jalz.2006.05.2030  0.22
2014 Rutherford NJ, Moore BD, Golde TE, Giasson BI. Divergent effects of the H50Q and G51D SNCA mutations on the aggregation of α-synuclein. Journal of Neurochemistry. 131: 859-67. PMID 24984882 DOI: 10.1111/Jnc.12806  0.218
2021 Trudler D, Nazor KL, Eisele YS, Grabauskas T, Dolatabadi N, Parker J, Sultan A, Zhong Z, Goodwin MS, Levites Y, Golde TE, Kelly JW, Sierks MR, Schork NJ, Karin M, et al. Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33833060 DOI: 10.1073/pnas.2025847118  0.218
2006 Klein RL, Dayton RD, Leidenheimer NJ, Jansen K, Golde TE, Zweig RM. Efficient neuronal gene transfer with AAV8 leads to neurotoxic levels of tau or green fluorescent proteins. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 517-27. PMID 16325474 DOI: 10.1016/j.ymthe.2005.10.008  0.216
2020 Zu T, Guo S, Bardhi O, Ryskamp DA, Li J, Khoramian Tusi S, Engelbrecht A, Klippel K, Chakrabarty P, Nguyen L, Golde TE, Sonenberg N, Ranum LPW. Metformin inhibits RAN translation through PKR pathway and mitigates disease in ALS/FTD mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 32690681 DOI: 10.1073/Pnas.2005748117  0.216
2012 Gu JW, Rizzo P, Pannuti A, Golde T, Osborne B, Miele L. Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy. Vascular Cell. 4: 7. PMID 22487493 DOI: 10.1186/2045-824X-4-7  0.214
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, Lee S, Regenhardt RW, McGarvey NH, Ayers JI, Notterpek L, Borchelt DR, Golde TE, Giasson BI. Intramuscular injection of α-synuclein induces CNS α-synuclein pathology and a rapid-onset motor phenotype in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10732-7. PMID 25002524 DOI: 10.1073/Pnas.1321785111  0.211
2013 Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular Neurodegeneration. 8: 17. PMID 23714769 DOI: 10.1186/1750-1326-8-17  0.211
2010 Chakrabarty P, Das P, Golde TE. Current and Future Therapies for Alzheimer Disease Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 711-774. DOI: 10.1002/9780470572702.ch34  0.21
2015 Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. IFN-γ promotes τ phosphorylation without affecting mature tangles. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26156074 DOI: 10.1096/Fj.15-275834  0.209
2017 Hossain F, Peng Y, Pannuti A, Backus K, Golde T, Osborne B, Miele L. Abstract P5-07-06: A novel non-canonical Notch1-IKKα-mTORC2-AKT pathway maintains survival in triple negative breast cancer cells and cancer stem-like cells Cancer Research. 77. DOI: 10.1158/1538-7445.Sabcs16-P5-07-06  0.208
2002 Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE. Identification of a novel family of presenilin homologues. Human Molecular Genetics. 11: 1037-44. PMID 11978763 DOI: 10.1093/Hmg/11.9.1037  0.205
2019 Magno L, Lessard CB, Martins M, Lang V, Cruz P, Asi Y, Katan M, Bilsland J, Lashley T, Chakrabarty P, Golde TE, Whiting PJ. Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph. Alzheimer's Research & Therapy. 11: 16. PMID 30711010 DOI: 10.1186/S13195-019-0469-0  0.205
2014 Sacino AN, Brooks M, McKinney AB, Thomas MA, Shaw G, Golde TE, Giasson BI. Brain injection of α-synuclein induces multiple proteinopathies, gliosis, and a neuronal injury marker. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 12368-78. PMID 25209277 DOI: 10.1523/Jneurosci.2102-14.2014  0.204
2018 Futch H, Grippin A, Kuhn Z, Hoang-Minh L, Truong V, Nelson J, Hao N, Cruz P, Ran Y, Reynolds B, Mitchell D, Golde T. DDIS-06. AAV TOOLKIT ENABLING PRECISION COMBINATORIAL VIROTHERAPY FOR GLIOBLASTOMA Neuro-Oncology. 20: vi70-vi70. DOI: 10.1093/Neuonc/Noy148.285  0.203
2023 Herdt AR, Peng H, Dickson DW, Golde TE, Eckman EA, Lee CW. Brain Targeted AAV1-GALC Gene Therapy Reduces Psychosine and Extends Lifespan in a Mouse Model of Krabbe Disease. Genes. 14. PMID 37628569 DOI: 10.3390/genes14081517  0.203
2009 Rizzo P, Osipo C, Pannuti A, Golde T, Osborne B, Miele L. Targeting Notch signaling cross-talk with estrogen receptor and ErbB-2 in breast cancer. Advances in Enzyme Regulation. 49: 134-41. PMID 19344631 DOI: 10.1016/J.Advenzreg.2009.01.008  0.201
2019 Ofori E, DeKosky ST, Febo M, Colon-Perez L, Chakrabarty P, Duara R, Adjouadi M, Golde TE, Vaillancourt DE. Free-water imaging of the hippocampus is a sensitive marker of Alzheimer's disease. Neuroimage. Clinical. 24: 101985. PMID 31470214 DOI: 10.1016/J.Nicl.2019.101985  0.2
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice. Acta Neuropathologica. 127: 645-65. PMID 24659240 DOI: 10.1007/S00401-014-1268-0  0.199
1999 Rennert H, Golde T, Wilson RB, Spitalnik SL, Van Deerlin VM, Leonard DG. A novel, non-nested reverse-transcriptase polymerase chain reaction (RT-PCR) test for the detection of the t(15;17) translocation: a comparative study of RT-PCR cytogenetics, and fluorescence In situ hybridization. Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology. 4: 195-209. PMID 10553020 DOI: 10.1016/S1084-8592(99)80023-X  0.199
2019 Liu G, Levites Y, Golde TE, Lee G. P4-157: ROLE OF FYN IN A MOUSE MODEL OF TAU P301L TAUOPATHY Alzheimer's & Dementia. 15: P1334-P1335. DOI: 10.1016/J.Jalz.2019.06.3819  0.198
1996 Cook DG, Sung JC, Golde TE, Felsenstein KM, Wojczyk BS, Tanzi RE, Trojanowski JQ, Lee VM, Doms RW. Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites. Proceedings of the National Academy of Sciences of the United States of America. 93: 9223-8. PMID 8799182 DOI: 10.1073/Pnas.93.17.9223  0.196
2017 Dhillon JS, Riffe C, Moore BD, Ran Y, Chakrabarty P, Golde TE, Giasson BI. A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies. Plos One. 12: e0184731. PMID 28910367 DOI: 10.1371/Journal.Pone.0184731  0.194
2004 Nyborg AC, Kornilova AY, Jansen K, Ladd TB, Wolfe MS, Golde TE. Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. The Journal of Biological Chemistry. 279: 15153-60. PMID 14704149 DOI: 10.1074/jbc.M309305200  0.192
2017 Strickland MR, Koller EJ, Deng DZ, Ceballos-Diaz C, Golde TE, Chakrabarty P. Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration. Neurobiology of Disease. 110: 133-141. PMID 29196213 DOI: 10.1016/J.Nbd.2017.11.007  0.192
2023 Ofori E, Vaillancourt DE, Greig-Custo MT, Barker W, Hanson K, DeKosky ST, Garvan CS, Adjouadi M, Golde T, Loewenstein DA, Stecher C, Fowers R, Duara R. Free-water imaging reveals unique brain microstructural deficits in hispanic individuals with Dementia. Brain Imaging and Behavior. PMID 37903991 DOI: 10.1007/s11682-023-00819-w  0.189
2017 Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE. γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct. Embo Molecular Medicine. PMID 28539479 DOI: 10.15252/Emmm.201607265  0.188
2015 Jung JI, Price AR, Ladd TB, Ran Y, Park HJ, Ceballos-Diaz C, Smithson LA, Hochhaus G, Tang Y, Akula R, Ba S, Koo EH, Shapiro G, Felsenstein KM, Golde TE. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Molecular Neurodegeneration. 10: 29. PMID 26169917 DOI: 10.1186/S13024-015-0021-Z  0.187
2015 Rutherford NJ, Sacino AN, Brooks M, Ceballos-Diaz C, Ladd TB, Howard JK, Golde TE, Giasson BI. Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice. Molecular Neurodegeneration. 10: 32. PMID 26223783 DOI: 10.1186/S13024-015-0029-4  0.185
2018 Sorrentino ZA, Xia Y, Funk C, Riffe CJ, Rutherford NJ, Diaz CC, Sacino AN, Price ND, Golde TE, Giasson BI, Chakrabarty P. Motor neuron loss and neuroinflammation in a model of α-synuclein-induced neurodegeneration. Neurobiology of Disease. PMID 30195075 DOI: 10.1016/J.Nbd.2018.09.005  0.184
2010 Lewis J, Golde TE. Sorting out frontotemporal dementia? Neuron. 68: 601-3. PMID 21092851 DOI: 10.1016/J.Neuron.2010.11.014  0.182
2018 Golde TE, DeKosky ST, Galasko D. Alzheimer's disease: The right drug, the right time. Science (New York, N.Y.). 362: 1250-1251. PMID 30545877 DOI: 10.1126/Science.Aau0437  0.181
2016 Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. Proteolysis of α-Synuclein Fibrils in the Lysosomal Pathway Limits Induction of Inclusion Pathology. Journal of Neurochemistry. PMID 27424880 DOI: 10.1111/Jnc.13743  0.181
2008 Chakrabarty P, Nimcheski K, Golde TE, Jansen K, Verbeeck C, Das P. P3-354: Role of IL-6-mediated chronic neuroinflammation on amyloid pathology Alzheimer's & Dementia. 4: T625-T625. DOI: 10.1016/J.Jalz.2008.05.1924  0.18
2007 Li T, Wen H, Brayton C, Das P, Smithson LA, Fauq A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. The Journal of Biological Chemistry. 282: 32264-73. PMID 17827153 DOI: 10.1074/Jbc.M703649200  0.18
2020 Knopman D, Lemere CA, Lamb BT, Craft S, Gitlin LN, Golde TE, Pericak-Vance M, Sano M, Schellenberg G, Schneider JA, Zheng H, Khachaturian Z, Snyder HM, Carrillo MC. Scientific Advising and Reviewing: On strengthening the bond between the Alzheimer's Association and the scientific community. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32426924 DOI: 10.1002/Alz.12059  0.178
2017 Koller EJ, Brooks MM, Golde TE, Giasson BI, Chakrabarty P. Inflammatory pre-conditioning restricts the seeded induction of α-synuclein pathology in wild type mice. Molecular Neurodegeneration. 12: 1. PMID 28049533 DOI: 10.1186/S13024-016-0142-Z  0.177
2004 Levites Y, Das P, Golde TE. P-346 Anti-A1–16, Aβ35–40 and Aβ35–42 single-chain variable region fragments as potential therapeutic agents for AD Neurobiology of Aging. 25: S573. DOI: 10.1016/S0197-4580(04)81904-3  0.176
2021 Chu WT, Wang WE, Zaborszky L, Golde TE, DeKosky S, Duara R, Loewenstein DA, Adjouadi M, Coombes SA, Vaillancourt DE. Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract. Neurology. PMID 34906980 DOI: 10.1212/WNL.0000000000013206  0.174
2006 Sato T, Nyborg AC, Iwata N, Diehl TS, Saido TC, Golde TE, Wolfe MS. Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry. 45: 8649-56. PMID 16834339 DOI: 10.1021/bi060597g  0.172
2015 Ran Y, Ladd GZ, Ceballos-Diaz C, Jung JI, Greenbaum D, Felsenstein KM, Golde TE. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors. Plos One. 10: e0128619. PMID 26046535 DOI: 10.1371/Journal.Pone.0128619  0.171
2012 Tebbenkamp AT, Crosby KW, Siemienski ZB, Brown HH, Golde TE, Borchelt DR. Analysis of proteolytic processes and enzymatic activities in the generation of huntingtin n-terminal fragments in an HEK293 cell model. Plos One. 7: e50750. PMID 23236391 DOI: 10.1371/Journal.Pone.0050750  0.168
2017 Sorrentino ZA, Brooks MMT, Hudson V, Rutherford NJ, Golde TE, Giasson BI, Chakrabarty P. Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity. Molecular Neurodegeneration. 12: 40. PMID 28552073 DOI: 10.1186/S13024-017-0182-Z  0.168
2014 Felsenstein KM, Park H, Ran Y, Jung J, Holmes O, Smithson L, Ceballos-Diaz C, Wolfe MS, Hauger R, Ryabinin A, Golde TE. O2-06-03: CAN WE TARGET CORTICOTROPIN RELEASING FACTOR (CRF) FOR THERAPEUTIC BENEFIT IN AD? Alzheimer's & Dementia. 10: P175-P175. DOI: 10.1016/J.Jalz.2014.04.188  0.167
2014 Kim JY, Grunke SD, Levites Y, Golde TE, Jankowsky JL. Intracerebroventricular viral injection of the neonatal mouse brain for persistent and widespread neuronal transduction. Journal of Visualized Experiments : Jove. 51863. PMID 25286085 DOI: 10.3791/51863  0.165
2015 Sacino AN, Ayers JI, Brooks MM, Chakrabarty P, Hudson VJ, Howard JK, Golde TE, Giasson BI, Borchelt DR. Non-prion-type transmission in A53T α-synuclein transgenic mice: a normal component of spinal homogenates from naïve non-transgenic mice induces robust α-synuclein pathology. Acta Neuropathologica. PMID 26541429 DOI: 10.1007/S00401-015-1505-1  0.165
2021 Cockey SG, McFarland KN, Koller EJ, Brooks MMT, Gonzalez De La Cruz E, Cruz PE, Ceballos-Diaz C, Rosario AM, Levites YR, Borchelt DR, Golde TE, Giasson BI, Chakrabarty P. Il-10 signaling reduces survival in mouse models of synucleinopathy. Npj Parkinson's Disease. 7: 30. PMID 33741985 DOI: 10.1038/s41531-021-00169-8  0.162
2016 Leclerc JL, Santiago-Moreno J, Dang A, Lampert AS, Cruz PE, Rosario AM, Golde TE, Doré S. Increased brain hemopexin levels improve outcomes after intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27864463 DOI: 10.1177/0271678X16679170  0.16
2003 Golde TE, Eckman CB. Physiologic and pathologic events mediated by intramembranous and juxtamembranous proteolysis. Science's Stke : Signal Transduction Knowledge Environment. 2003: RE4. PMID 12621149 DOI: 10.1126/stke.2003.172.re4  0.157
2009 Golde TE, Petrucelli L. "What kills neurons in neurodegenerative diseases?", a review series in an open access journal. Molecular Neurodegeneration. 4: 7. PMID 19193221 DOI: 10.1186/1750-1326-4-7  0.157
2013 Roderick JE, Gonzalez-Perez G, Kuksin CA, Dongre A, Roberts ER, Srinivasan J, Andrzejewski C, Fauq AH, Golde TE, Miele L, Minter LM. Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia. The Journal of Experimental Medicine. 210: 1311-29. PMID 23733784 DOI: 10.1084/Jem.20112615  0.157
2015 Ling IF, Golde TE, Galasko DR, Koo EH. Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans. Alzheimer's Research & Therapy. 7: 55. PMID 26244059 DOI: 10.1186/S13195-015-0137-Y  0.156
2017 Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, et al. A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Plos One. 12: e0173565. PMID 28467418 DOI: 10.1371/Journal.Pone.0173565  0.149
2006 Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochemical and Biophysical Research Communications. 340: 668-74. PMID 16376853 DOI: 10.1016/J.Bbrc.2005.12.063  0.148
2009 Golde TE. The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease. Molecular Neurodegeneration. 4: 8. PMID 19193222 DOI: 10.1186/1750-1326-4-8  0.147
2020 Febo M, Perez PD, Ceballos-Diaz C, Colon-Perez LM, Zeng H, Ofori E, Golde TE, Vaillancourt DE, Chakrabarty P. Diffusion magnetic resonance imaging-derived free water detects neurodegenerative pattern induced by interferon-γ. Brain Structure & Function. PMID 31894407 DOI: 10.1007/S00429-019-02017-1  0.144
2002 Das P, Golde TE. Open peer commentary regarding Abeta immunization and CNS inflammation by Pasinetti et al. Neurobiology of Aging. 23: 671-4; discussion 68. PMID 12392769  0.143
2013 Chakrabarty P, Rosario A, Cruz P, Siemienski Z, Ceballos-Diaz C, Crosby K, Jansen K, Borchelt DR, Kim JY, Jankowsky JL, Golde TE, Levites Y. Capsid serotype and timing of injection determines AAV transduction in the neonatal mice brain. Plos One. 8: e67680. PMID 23825679 DOI: 10.1371/Journal.Pone.0067680  0.142
2004 Nyborg AC, Jansen K, Ladd TB, Fauq A, Golde TE. A signal peptide peptidase (SPP) reporter activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin. The Journal of Biological Chemistry. 279: 43148-56. PMID 15252014 DOI: 10.1074/jbc.M405879200  0.141
2009 Golde TE, Wolfe MS, Greenbaum DC. Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins. Seminars in Cell & Developmental Biology. 20: 225-30. PMID 19429495 DOI: 10.1016/J.Semcdb.2009.02.003  0.138
2012 Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proceedings of the National Academy of Sciences of the United States of America. 109: 21486-91. PMID 23236186 DOI: 10.1073/Pnas.1216016110  0.137
2013 Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL. Viral transduction of the neonatal brain delivers controllable genetic mosaicism for visualising and manipulating neuronal circuits in vivo. The European Journal of Neuroscience. 37: 1203-20. PMID 23347239 DOI: 10.1111/Ejn.12126  0.135
2004 Nyborg AC, Ladd TB, Jansen K, Kornilova A, Wolfe MS, Golde TE. P4-276 Presenilin homolog, signal peptide peptidase, provides a basis for understanding intramembrane aspartic proteolytic cleavage Neurobiology of Aging. 25: S554. DOI: 10.1016/S0197-4580(04)81834-7  0.135
2006 Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Molecular Neurodegeneration. 1: 16. PMID 17105660 DOI: 10.1186/1750-1326-1-16  0.134
2006 Guojun B, Huaxi X, Golde TE. Zoom in on neurodegeneration Molecular Neurodegeneration. 1. DOI: 10.1186/1750-1326-1-1  0.133
2010 Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. Journal of Neuroscience Methods. 194: 144-53. PMID 20951738 DOI: 10.1016/J.Jneumeth.2010.10.010  0.13
2005 Minter LM, Turley DM, Das P, Shin HM, Joshi I, Lawlor RG, Cho OH, Palaga T, Gottipati S, Telfer JC, Kostura L, Fauq AH, Simpson K, Such KA, Miele L, ... Golde TE, et al. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunology. 6: 680-8. PMID 15991363 DOI: 10.1038/Ni1209X  0.123
2024 Weber DM, Taylor SW, Lagier RJ, Kim JC, Goldman SM, Clarke NJ, Vaillancourt DE, Duara R, McFarland KN, Wang WE, Golde TE, Racke MK. Clinical utility of plasma Aβ42/40 ratio by LC-MS/MS in Alzheimer's disease assessment. Frontiers in Neurology. 15: 1364658. PMID 38595851 DOI: 10.3389/fneur.2024.1364658  0.12
2005 Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE. Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene. 24: 6333-44. PMID 15940249 DOI: 10.1038/Sj.Onc.1208783  0.115
2009 Parvanova I, Epiphanio S, Fauq A, Golde TE, Prudêncio M, Mota MM. A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. Plos One. 4: e5078. PMID 19337374 DOI: 10.1371/journal.pone.0005078  0.11
2009 Sun HS, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, Macdonald JF, Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neuroscience. 12: 1300-7. PMID 19734892 DOI: 10.1038/Nn.2395  0.107
2008 Rizzo P, Osipo C, Foreman K, Golde T, Osborne B, Miele L. Rational targeting of Notch signaling in cancer. Oncogene. 27: 5124-31. PMID 18758481 DOI: 10.1038/Onc.2008.226  0.104
2018 Manfredsson FP, Tansey MG, Golde TE. Challenges in Passive Immunization Strategies to Treat Parkinson Disease. Jama Neurology. PMID 29913004 DOI: 10.1001/Jamaneurol.2018.0346  0.103
2018 Hossain F, Sorrentino C, Ucar DA, Peng Y, Matossian M, Wyczechowska D, Crabtree J, Zabaleta J, Morello S, Del Valle L, Burow M, Collins-Burow B, Pannuti A, Minter LM, Golde TE, et al. Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways. Frontiers in Oncology. 8: 575. PMID 30564555 DOI: 10.3389/Fonc.2018.00575  0.103
2023 Hossain F, Ucar DA, Monticone G, Ran Y, Majumder S, Larter K, Luu H, Wyczechowska D, Heidari S, Xu K, Shanthalingam S, Matossian M, Xi Y, Burow M, Collins-Burow B, ... ... Golde T, et al. Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer. Frontiers in Immunology. 14: 1244159. PMID 37901240 DOI: 10.3389/fimmu.2023.1244159  0.103
2008 Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA. Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood. 112: 1813-21. PMID 18550850 DOI: 10.1182/Blood-2008-03-144980  0.102
1990 Hoofer C, Estus S, Golde TE, Younkln SG. QUANTITATIVE ANALYSIS OF GENE EXPRESSION IN ALZHEIMERʼS DISEASE BY POLYMERASE CHAIN REACTION AMPLIFICATION OF REVERSE TRANSCRIBED mRNAs Journal of Neuropathology and Experimental Neurology. 49: 334. DOI: 10.1097/00005072-199005000-00224  0.101
2010 Pannuti A, Foreman K, Rizzo P, Osipo C, Golde T, Osborne B, Miele L. Targeting Notch to target cancer stem cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 3141-52. PMID 20530696 DOI: 10.1158/1078-0432.Ccr-09-2823  0.099
2015 Ofori E, Pasternak O, Planetta PJ, Burciu R, Snyder A, Febo M, Golde TE, Okun MS, Vaillancourt DE. Increased free water in the substantia nigra of Parkinson's disease: a single-site and multi-site study. Neurobiology of Aging. 36: 1097-104. PMID 25467638 DOI: 10.1016/J.Neurobiolaging.2014.10.029  0.099
2022 Lichlyter DA, Krumm ZA, Golde TA, Doré S. Role of CRF and the hypothalamic-pituitary-adrenal axis in stroke: Revisiting temporal considerations and targeting a new generation of therapeutics. The Febs Journal. PMID 35108458 DOI: 10.1111/febs.16380  0.098
2021 Krumm ZA, Lloyd GM, Francis CP, Nasif LH, Mitchell DA, Golde TE, Giasson BI, Xia Y. Precision therapeutic targets for COVID-19. Virology Journal. 18: 66. PMID 33781287 DOI: 10.1186/s12985-021-01526-y  0.098
2008 Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH, Osborne BA. Notch signaling is activated by TLR stimulation and regulates macrophage functions. European Journal of Immunology. 38: 174-83. PMID 18085664 DOI: 10.1002/Eji.200636999  0.097
2014 Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA. Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells. Frontiers in Immunology. 5: 54. PMID 24611064 DOI: 10.3389/Fimmu.2014.00054  0.096
2018 Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. Iscience. 11: 294-304. PMID 30639851 DOI: 10.1016/J.Isci.2018.12.026  0.094
2015 Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y. Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 53-62. PMID 25228069 DOI: 10.1038/Mt.2014.180  0.093
2023 von Roemeling C, Yegorov O, Yang C, Klippel K, Russell R, Trivedi V, Bhatia A, Doonan B, Carpenter S, Ryu D, Grippen A, Futch H, Ran Y, Hoang-Minh L, Weidert F, ... Golde T, et al. CXCL9 recombinant adeno-associated virus (AAV) virotherapy sensitizes glioblastoma (GBM) to anti-PD-1 immune checkpoint blockade. Research Square. PMID 38014191 DOI: 10.21203/rs.3.rs-3463730/v1  0.091
2009 Rahimi N, Golde TE, Meyer RD. Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells. Cancer Research. 69: 2607-14. PMID 19276374 DOI: 10.1158/0008-5472.Can-08-2905  0.089
2014 March A, Borchelt D, Golde T, Janus C. Differences in memory development among C57BL/6NCrl, 129S2/SvPasCrl, and FVB/NCrl mice after delay and trace fear conditioning. Comparative Medicine. 64: 4-12. PMID 24672832  0.088
2014 Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM. NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome. Frontiers in Immunology. 5: 249. PMID 24904593 DOI: 10.3389/Fimmu.2014.00249  0.087
2007 Curry CL, Reed LL, Broude E, Golde TE, Miele L, Foreman KE. Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling. Molecular Cancer Therapeutics. 6: 1983-92. PMID 17604336 DOI: 10.1158/1535-7163.Mct-07-0093  0.087
2009 Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA. Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. Blood. 113: 1689-98. PMID 19001083 DOI: 10.1182/Blood-2008-03-147967  0.084
2008 Osipo C, Patel P, Rizzo P, Clementz AG, Hao L, Golde TE, Miele L. ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor. Oncogene. 27: 5019-32. PMID 18469855 DOI: 10.1038/Onc.2008.149  0.081
2015 Bean LA, Kumar A, Rani A, Guidi M, Rosario AM, Cruz PE, Golde TE, Foster TC. Re-Opening the Critical Window for Estrogen Therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 16077-16093. PMID 26658861 DOI: 10.1523/Jneurosci.1890-15.2015  0.079
1986 Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the mouse IgA gene: nucleotide sequence comparison of IgA in BALB/c and Mus pahari. Current Topics in Microbiology and Immunology. 127: 141-8. PMID 3731840 DOI: 10.1007/978-3-642-71304-0_17  0.078
2020 Majumder S, Crabtree JS, Golde TE, Minter LM, Osborne BA, Miele L. Targeting Notch in oncology: the path forward. Nature Reviews. Drug Discovery. PMID 33293690 DOI: 10.1038/s41573-020-00091-3  0.076
2003 Palaga T, Miele L, Golde TE, Osborne BA. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 3019-24. PMID 12960327 DOI: 10.4049/Jimmunol.171.6.3019  0.075
2006 Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA. Notch1 augments NF-kappaB activity by facilitating its nuclear retention. The Embo Journal. 25: 129-38. PMID 16319921 DOI: 10.1038/Sj.Emboj.7600902  0.075
2009 Cho OH, Shin HM, Miele L, Golde TE, Fauq A, Minter LM, Osborne BA. Notch regulates cytolytic effector function in CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 3380-9. PMID 19265115 DOI: 10.4049/Jimmunol.0802598  0.075
2008 Jiang P, Ko LW, Jansen KR, Golde TE, Yen SH. Using leucine zipper to facilitate alpha-synuclein assembly. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3165-74. PMID 18492724 DOI: 10.1096/fj.08-108365  0.074
1988 Osborne BA, Golde TE, Schwartz RL, Rudikoff S. Evolution of the IgA heavy chain gene in the genus Mus. Genetics. 119: 925-31. PMID 2842228  0.073
2019 Golde TE. Harnessing Immunoproteostasis to Treat Neurodegenerative Disorders. Neuron. 101: 1003-1015. PMID 30897353 DOI: 10.1016/j.neuron.2019.02.027  0.072
2014 Sacino AN, Brooks M, Thomas MA, McKinney AB, McGarvey NH, Rutherford NJ, Ceballos-Diaz C, Robertson J, Golde TE, Giasson BI. Erratum to: Amyloidogenic α-synuclein seeds do not invariably induce rapid, widespread pathology in mice Acta Neuropathologica. 128: 897-898. DOI: 10.1007/S00401-014-1346-3  0.07
2010 Grudzien P, Lo S, Albain KS, Robinson P, Rajan P, Strack PR, Golde TE, Miele L, Foreman KE. Inhibition of Notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation. Anticancer Research. 30: 3853-67. PMID 21036696  0.065
2008 Osipo C, Golde TE, Osborne BA, Miele LA. Off the beaten pathway: the complex cross talk between Notch and NF-kappaB. Laboratory Investigation; a Journal of Technical Methods and Pathology. 88: 11-7. PMID 18059366 DOI: 10.1038/Labinvest.3700700  0.065
2007 Fauq AH, Simpson K, Maharvi GM, Golde T, Das P. A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. Bioorganic & Medicinal Chemistry Letters. 17: 6392-5. PMID 17897827 DOI: 10.1016/j.bmcl.2007.07.062  0.062
2019 Osking Z, Ayers JI, Hildebrandt R, Skruber K, Brown H, Ryu D, Eukovich AR, Golde TE, Borchelt DR, Read TA, Vitriol EA. ALS-Linked SOD1 Mutants Enhance Neurite Outgrowth and Branching in Adult Motor Neurons. Iscience. 19: 448-449. PMID 31425915 DOI: 10.1016/j.isci.2019.08.004  0.057
2020 Mitra A, Shanthalingam S, Sherman HL, Singh K, Canakci M, Torres JA, Lawlor R, Ran Y, Golde TE, Miele L, Thayumanavan S, Minter LM, Osborne BA. CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells. Frontiers in Immunology. 11: 735. PMID 32457739 DOI: 10.3389/Fimmu.2020.00735  0.055
2018 Chandiran K, Lawlor R, Pannuti A, Perez GG, Srinivasan J, Golde TE, Miele L, Osborne BA, Minter LM. Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29. Molecular Immunology. 99: 191-198. PMID 29807327 DOI: 10.1016/J.Molimm.2018.05.002  0.055
2013 Golde T, Schuldt C, Schnauß J, Strehle D, Glaser M, Käs J. Fluorescent beads disintegrate actin networks. Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. 88: 044601. PMID 24229308 DOI: 10.1103/Physreve.88.044601  0.053
2018 Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L. Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses. Frontiers in Immunology. 9: 1288. PMID 29915603 DOI: 10.3389/Fimmu.2018.01288  0.052
2008 Rizzo P, Osipo C, Foreman K, Yun J, Golde T, Osborne B, Miele L. Rational Targeting of Notch in Breast Cancer Aacr Education Book. 2008: 491-495. DOI: 10.1158/Aacr.Edb-08-8135  0.037
2020 Mitra A, Shanthalingam S, Sherman HL, Singh K, Canakci M, Torres JA, Lawlor R, Ran Y, Golde TE, Miele L, Thayumanavan S, Minter LM, Osborne BA. CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells Frontiers in Immunology. 11. DOI: 10.3389/fimmu.2020.00735  0.027
2018 Leclerc JL, Hernandez D, Satyavarapu I, Chakrabarty P, Golde TE, Doré S. Abstract WMP103: Role of the Soluble TLR4 Decoy Receptor on ICH Outcomes Stroke. 49. DOI: 10.1161/Str.49.Suppl_1.Wmp103  0.02
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