| Year |
Citation |
Score |
| 2018 |
Ho Wei L, Arastoo M, Georgiou I, Manning DR, Riobo-Del Galdo NA. Activation of the Gi protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia. Plos One. 13: e0203170. PMID 30148884 DOI: 10.1371/Journal.Pone.0203170 |
0.479 |
|
| 2018 |
Cheng L, Al-Owais MM, Covarrubias M, Koch WJ, Manning DR, Peers C, Riobo-Del Galdo N. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs the cardiac action potential duration. The Journal of Biological Chemistry. PMID 29802197 DOI: 10.1074/Jbc.Ra118.001989 |
0.416 |
|
| 2018 |
Guo X, Riobo-Del Galdo NA, Kim EJ, Grant GR, Manning DR. Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G13. Plos One. 13: e0197442. PMID 29763457 DOI: 10.1371/Journal.Pone.0197442 |
0.517 |
|
| 2015 |
Manning DR, Shen F, Riobo NA. Evaluating the Activity of Smoothened Toward G Proteins Using [³⁵S]Guanosine 5'-(3-O-thio)triphosphate ([³⁵S]GTPγS). Methods in Molecular Biology (Clifton, N.J.). 1322: 35-44. PMID 26179037 DOI: 10.1007/978-1-4939-2772-2_4 |
0.517 |
|
| 2013 |
Shen F, Cheng L, Douglas AE, Riobo NA, Manning DR. Smoothened is a fully competent activator of the heterotrimeric G protein G(i). Molecular Pharmacology. 83: 691-7. PMID 23292797 DOI: 10.1124/mol.112.082511 |
0.438 |
|
| 2011 |
Polizio AH, Chinchilla P, Chen X, Manning DR, Riobo NA. Sonic Hedgehog activates the GTPases Rac1 and RhoA in a Gli-independent manner through coupling of smoothened to Gi proteins. Science Signaling. 4: pt7. PMID 22114142 DOI: 10.1126/Scisignal.2002396 |
0.508 |
|
| 2011 |
Douglas AE, Heim JA, Shen F, Almada LL, Riobo NA, Fernández-Zapico ME, Manning DR. The alpha subunit of the G protein G13 regulates activity of one or more Gli transcription factors independently of smoothened. The Journal of Biological Chemistry. 286: 30714-22. PMID 21757753 DOI: 10.1074/Jbc.M111.219279 |
0.537 |
|
| 2011 |
Polizio AH, Chinchilla P, Chen X, Kim S, Manning DR, Riobo NA. Heterotrimeric Gi proteins link Hedgehog signaling to activation of Rho small GTPases to promote fibroblast migration. The Journal of Biological Chemistry. 286: 19589-96. PMID 21474452 DOI: 10.1074/Jbc.M110.197111 |
0.483 |
|
| 2010 |
Crouthamel M, Abankwa D, Zhang L, DiLizio C, Manning DR, Hancock JF, Wedegaertner PB. An N-terminal polybasic motif of Gαq is required for signaling and influences membrane nanodomain distribution. Molecular Pharmacology. 78: 767-77. PMID 20664004 DOI: 10.1124/Mol.110.066340 |
0.323 |
|
| 2009 |
Zhang L, Brass LF, Manning DR. The Gq and G12 families of heterotrimeric G proteins report functional selectivity. Molecular Pharmacology. 75: 235-41. PMID 18952767 DOI: 10.1124/Mol.108.050906 |
0.517 |
|
| 2007 |
Riobo NA, Manning DR. Pathways of signal transduction employed by vertebrate Hedgehogs. The Biochemical Journal. 403: 369-79. PMID 17419683 DOI: 10.1042/Bj20061723 |
0.429 |
|
| 2006 |
Riobo NA, Saucy B, Dilizio C, Manning DR. Activation of heterotrimeric G proteins by Smoothened. Proceedings of the National Academy of Sciences of the United States of America. 103: 12607-12. PMID 16885213 DOI: 10.1073/Pnas.0600880103 |
0.52 |
|
| 2006 |
Zhang L, DiLizio C, Kim D, Smyth EM, Manning DR. The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Molecular Pharmacology. 69: 1433-40. PMID 16418336 DOI: 10.1124/Mol.105.019703 |
0.52 |
|
| 2005 |
Riobo NA, Manning DR. Receptors coupled to heterotrimeric G proteins of the G12 family. Trends in Pharmacological Sciences. 26: 146-54. PMID 15749160 DOI: 10.1016/J.Tips.2005.01.007 |
0.495 |
|
| 2003 |
Manning DR. Evidence mounts for receptor-independent activation of heterotrimeric G proteins normally in vivo: positioning of the mitotic spindle in C. elegans. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe35. PMID 12928525 DOI: 10.1126/Stke.2003.196.Pe35 |
0.543 |
|
| 2002 |
Yang J, Wu J, Jiang H, Mortensen R, Austin S, Manning DR, Woulfe D, Brass LF. Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. The Journal of Biological Chemistry. 277: 46035-42. PMID 12297509 DOI: 10.1074/Jbc.M208519200 |
0.482 |
|
| 2002 |
Manning DR. Measures of efficacy using G proteins as endpoints: differential engagement of G proteins through single receptors. Molecular Pharmacology. 62: 451-2. PMID 12181420 DOI: 10.1124/Mol.62.3.451 |
0.487 |
|
| 2002 |
Siehler S, Manning DR. Pathways of transduction engaged by sphingosine 1-phosphate through G protein-coupled receptors. Biochimica Et Biophysica Acta. 1582: 94-9. PMID 12069815 DOI: 10.1016/S1388-1981(02)00142-7 |
0.492 |
|
| 2002 |
Windh RT, Manning DR. Analysis of G protein activation in Sf9 and mammalian cells by agonist-promoted [35S]GTP gamma S binding. Methods in Enzymology. 344: 3-14. PMID 11771391 DOI: 10.1016/S0076-6879(02)44702-7 |
0.484 |
|
| 2002 |
Windh RT, Manning DR. Expression of G protein-coupled receptors and G proteins in Sf9 cells: analysis of coupling by radioligand binding. Methods in Enzymology. 343: 417-29. PMID 11665582 DOI: 10.1016/S0076-6879(02)43149-7 |
0.522 |
|
| 2001 |
Siehler S, Wang Y, Fan X, Windh RT, Manning DR. Sphingosine 1-phosphate activates nuclear factor-κB through Edg receptors: Activation through Edg-3 and Edg-5, but not Edg-1, in human embryonic kidney 293 cells Journal of Biological Chemistry. 276: 48733-48739. PMID 11673450 DOI: 10.1074/Jbc.M011072200 |
0.483 |
|
| 2001 |
Chen CA, Manning DR. Regulation of G proteins by covalent modification. Oncogene. 20: 1643-52. PMID 11313912 DOI: 10.1038/Sj.Onc.1204185 |
0.634 |
|
| 2000 |
Yang J, Wu J, Kowalska MA, Dalvi A, Prevost N, O'Brien PJ, Manning D, Poncz M, Lucki I, Blendy JA, Brass LF. Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs. Proceedings of the National Academy of Sciences of the United States of America. 97: 9984-9. PMID 10954748 DOI: 10.1073/Pnas.180194597 |
0.504 |
|
| 2000 |
Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. The Journal of Biological Chemistry. 275: 32129-34. PMID 10906137 DOI: 10.1074/Jbc.M004577200 |
0.498 |
|
| 2000 |
Chen CA, Manning DR. Regulation of galpha i palmitoylation by activation of the 5-hydroxytryptamine-1A receptor. The Journal of Biological Chemistry. 275: 23516-22. PMID 10818105 DOI: 10.1074/Jbc.M003439200 |
0.606 |
|
| 2000 |
Windh RT, Barr AJ, Manning DR. Insect Cell Systems to Study the Communication of Mammalian Receptors and G Proteins Handbook of Experimental Pharmacology. 148: 335-362. DOI: 10.1007/978-3-642-57081-0_13 |
0.539 |
|
| 1999 |
Wang Y, Windh RT, Chen CA, Manning DR. N-Myristoylation and betagamma play roles beyond anchorage in the palmitoylation of the G protein alpha(o) subunit. The Journal of Biological Chemistry. 274: 37435-42. PMID 10601316 DOI: 10.1074/Jbc.274.52.37435 |
0.523 |
|
| 1999 |
Windh RT, Lee MJ, Hla T, An S, Barr AJ, Manning DR. Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. The Journal of Biological Chemistry. 274: 27351-8. PMID 10488065 DOI: 10.1074/Jbc.274.39.27351 |
0.491 |
|
| 1999 |
Shahrestanifar M, Fan X, Manning DR. Lysophosphatidic acid activates NF-κB in fibroblasts. A requirement for multiple inputs Journal of Biological Chemistry. 274: 3828-3833. PMID 9920937 DOI: 10.1074/Jbc.274.6.3828 |
0.366 |
|
| 1997 |
Barr AJ, Manning DR. Agonist-independent activation of G(z) by the 5-hydroxytryptamine(1A) receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists Journal of Biological Chemistry. 272: 32979-32987. PMID 9407078 DOI: 10.1074/Jbc.272.52.32979 |
0.476 |
|
| 1997 |
Cowen DS, Molinoff PB, Manning DR. 5-hydroxytryptamine1A receptor-mediated increases in receptor expression and activation of nuclear factor-kappaB in transfected Chinese hamster ovary cells. Molecular Pharmacology. 52: 221-6. PMID 9271344 DOI: 10.1124/Mol.52.2.221 |
0.39 |
|
| 1997 |
Brass LF, Manning DR, Cichowski K, Abrams CS. Signaling through G proteins in platelets: To the integrins and beyond Thrombosis and Haemostasis. 78: 581-589. PMID 9198220 DOI: 10.1055/S-0038-1657593 |
0.51 |
|
| 1997 |
Barr AJ, Brass LF, Manning DR. Reconstitution of receptors and GTP-binding regulatory proteins (G proteins) in Sf9 cells. A direct evaluation of selectivity in receptor-G protein coupling Journal of Biological Chemistry. 272: 2223-2229. PMID 8999927 DOI: 10.1074/Jbc.272.4.2223 |
0.469 |
|
| 1997 |
Brass LF, Poncz M, Manning DR. G Proteins and the Early Events of Platelet Activation Advances in Molecular and Cell Biology. 18: 179-195. DOI: 10.1016/S1569-2558(08)60415-4 |
0.548 |
|
| 1996 |
Cowen DS, Sowers RS, Manning DR. Activation of a mitogen-activated protein kinase (ERK2) by the 5-hydroxytryptamine1A receptor is sensitive not only to inhibitors of phosphatidylinositol 3-kinase, but to an inhibitor of phosphatidylcholine hydrolysis. The Journal of Biological Chemistry. 271: 22297-300. PMID 8798386 DOI: 10.1074/Jbc.271.37.22297 |
0.465 |
|
| 1995 |
Wolf BA, Wertkin AM, Jolly YC, Yasuda RP, Wolfe BB, Konrad RJ, Manning D, Ravi S, Williamson JR, Lee VM. Muscarinic regulation of Alzheimer's disease amyloid precursor protein secretion and amyloid beta-protein production in human neuronal NT2N cells. The Journal of Biological Chemistry. 270: 4916-22. PMID 7876266 DOI: 10.1074/Jbc.270.9.4916 |
0.32 |
|
| 1995 |
Konrad RJ, Young RA, Record RD, Smith RM, Butkerait P, Manning D, Jarett L, Wolf BA. The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis. The Journal of Biological Chemistry. 270: 12869-76. PMID 7759545 DOI: 10.1074/Jbc.270.21.12869 |
0.388 |
|
| 1995 |
Butkerait P, Zheng Y, Hallak H, Graham TE, Miller HA, Burris KD, Molinoff PB, Manning DR. Expression of the human 5-hydroxytryptamine1A receptor in Sf9 cells. Reconstitution of a coupled phenotype by co-expression of mammalian G protein subunits. The Journal of Biological Chemistry. 270: 18691-9. PMID 7629202 DOI: 10.1074/Jbc.270.31.18691 |
0.43 |
|
| 1993 |
Vardi N, Matesic DF, Manning DR, Liebman PA, Sterling P. Identification of a G-protein in depolarizing rod bipolar cells. Visual Neuroscience. 10: 473-8. PMID 8388245 DOI: 10.1017/S0952523800004697 |
0.413 |
|
| 1993 |
Brass LF, Hoxie JA, Manning DR. Signaling through G proteins and G protein-coupled receptors during platelet activation Thrombosis and Haemostasis. 70: 217-223. PMID 8236108 DOI: 10.1055/S-0038-1646194 |
0.527 |
|
| 1993 |
Brass LF, Hoxie JA, Kieber-Emmons T, Manning DR, Poncz M, Woolkalis M. Agonist receptors and G proteins as mediators of platelet activation Advances in Experimental Medicine and Biology. 344: 17-36. PMID 8209785 DOI: 10.1007/978-1-4615-2994-1_2 |
0.511 |
|
| 1991 |
Lounsbury KM, Casey PJ, Brass LF, Manning DR. Phosphorylation of Gz in human platelets: Selectivity and site of modification Journal of Biological Chemistry. 266: 22051-22056. PMID 1939224 |
0.32 |
|
| 1991 |
Brass LF, Manning DR, Williams AG, Woolkalis MJ, Poncz M. Receptor and G protein-mediated responses to thrombin in HEL cells Journal of Biological Chemistry. 266: 958-965. PMID 1845999 |
0.384 |
|
| 1991 |
Lewis JM, Woolkalis MJ, Gerton GL, Smith RM, Jarett L, Manning DR. Subcellular distribution of the alpha subunit(s) of Gi: visualization by immunofluorescent and immunogold labeling Cell Regulation. 2: 1097-1113. PMID 1801926 DOI: 10.1091/Mbc.2.12.1097 |
0.318 |
|
| 1991 |
Matesic DF, Manning DR, Luthin GR. Tissue-dependent association of muscarinic acetylcholine receptors with guanine nucleotide-binding regulatory proteins Molecular Pharmacology. 40: 347-353. PMID 1716729 |
0.437 |
|
| 1991 |
Manning DR, Brass LF. The role of GTP-binding proteins in platelet activation Thrombosis and Haemostasis. 66: 393-399. PMID 1665593 DOI: 10.1055/S-0038-1646426 |
0.489 |
|
| 1991 |
Brass LF, Manning DR. G proteins and low-molecular-weight GTP-binding proteins in platelets Trends in Cardiovascular Medicine. 1: 92-98. DOI: 10.1016/1050-1738(91)90017-9 |
0.453 |
|
| 1990 |
Gutierrez GE, Mundy GR, Manning DR, Hewlett EL, Katz MS. Transforming growth factor β enhances parathyroid hormone stimulation of adenylate cyclase in clonal osteoblast-like cells Journal of Cellular Physiology. 144: 438-447. PMID 2391378 DOI: 10.1002/Jcp.1041440311 |
0.376 |
|
| 1990 |
Cooper HS, Manning DR, Wax MB. G protein complement of SV40-transformed ciliary epithelial cells Current Eye Research. 9: 493-499. PMID 2166638 DOI: 10.3109/02713689008999615 |
0.48 |
|
| 1990 |
Williams AG, Woolkalis MJ, Poncz M, Manning DR, Gerwirtz AM, Brass LF. Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells Blood. 76: 721-730. PMID 2116927 |
0.402 |
|
| 1990 |
Manning DR. G proteins: Linkages with amine receptors Neuropsychopharmacology. 3: 447-455. PMID 1964050 |
0.45 |
|
| 1989 |
Matesic DF, Manning DR, Wolfe BB, Luthin GR. Pharmacological and biochemical characterization of complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein. The Journal of Biological Chemistry. 264: 21638-45. PMID 2513323 |
0.403 |
|
| 1989 |
Carlson KE, Brass LF, Manning DR. Thrombin and phorbol esters cause the selective phosphorylation of a G protein other than G(i) in human platelets Journal of Biological Chemistry. 264: 13298-13305. PMID 2502548 |
0.457 |
|
| 1988 |
Brass LF, Woolkalis MJ, Manning DR. Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase Journal of Biological Chemistry. 263: 5348-5355. PMID 2833506 |
0.386 |
|
| 1986 |
Mumby SM, Kahn RA, Manning DR, Gilman AG. Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins Proceedings of the National Academy of Sciences of the United States of America. 83: 265-269. PMID 3079909 DOI: 10.1073/Pnas.83.2.265 |
0.331 |
|
| 1986 |
Woolkalis MJ, Nakada MT, Manning DR. Alterations in components of adenylate cyclase associated with transformation of chicken embryo fibroblasts by Rous sarcoma virus Journal of Biological Chemistry. 261: 3408-3413. PMID 3005290 |
0.342 |
|
| 1983 |
Manning DR, Stull JT. Assessment of Ca2+-calmodulin formation in intact vertebrate skeletal muscle Methods in Enzymology. 74-82. PMID 6645972 DOI: 10.1016/S0076-6879(83)02009-1 |
0.485 |
|
| 1983 |
Manning DR, Gilman AG. The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins Journal of Biological Chemistry. 258: 7059-7063. PMID 6304074 |
0.352 |
|
| 1982 |
Manning DR, Stull JT. Myosin light chain phosphorylation-dephosphorylation in mammalian skeletal muscle The American Journal of Physiology. 242. PMID 7065172 DOI: 10.1152/Ajpcell.1982.242.3.C234 |
0.461 |
|
| 1980 |
Manning DR, DiSalvo J, Stull JT. Protein phosphorylation: Quantitative analysis in vivo and in intact cell systems Molecular and Cellular Endocrinology. 19: 1-19. PMID 6248400 DOI: 10.1016/0303-7207(80)90026-X |
0.544 |
|
| 1979 |
Manning DR, Stull JT. Myosin light chain phosphorylation and phosphorylase a activity in rat extensor digitorum longus muscle Biochemical and Biophysical Research Communications. 90: 164-170. PMID 496969 DOI: 10.1016/0006-291X(79)91604-8 |
0.472 |
|
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