| Year |
Citation |
Score |
| 2017 |
Dickerson SM, Kuchta RD. Protein Displacement by Herpes Helicase-Primase and the Key Role of UL42 during Helicase-Coupled DNA Synthesis by the Herpes Polymerase. Biochemistry. PMID 28505413 DOI: 10.1021/Acs.Biochem.6B01128 |
0.548 |
|
| 2017 |
Okochi KD, Monfregola L, Dickerson SM, McCaffrey R, Domaille DW, Yu C, Hafenstine GR, Jin Y, Cha JN, Kuchta RD, Caruthers M, Zhang W. Synthesis of Small Molecule/DNA Hybrids through On-Bead Amide Coupling Approach. The Journal of Organic Chemistry. PMID 28282138 DOI: 10.1021/Acs.Joc.6B02942 |
0.404 |
|
| 2016 |
Vashishtha AK, Kuchta RD. Effects of Acyclovir, Foscarnet, and Ribonucleotides on Herpes Simplex Virus-1 DNA Polymerase: Mechanistic Insights and a Novel Mechanism for Preventing Stable Incorporation of Ribonucleotides into DNA. Biochemistry. 55: 1168-77. PMID 26836009 DOI: 10.1021/Acs.Biochem.6B00065 |
0.582 |
|
| 2015 |
Vashishtha AK, Kuchta RD. Polymerase and exonuclease activities in herpes simplex virus type 1 DNA polymerase are not highly coordinated. Biochemistry. 54: 240-9. PMID 25517265 DOI: 10.1021/Bi500840V |
0.515 |
|
| 2014 |
Rodgers BJ, Elsharif NA, Vashisht N, Mingus MM, Mulvahill MA, Stengel G, Kuchta RD, Purse BW. Functionalized tricyclic cytosine analogues provide nucleoside fluorophores with improved photophysical properties and a range of solvent sensitivities Chemistry - a European Journal. 20: 2010-2015. PMID 24311229 DOI: 10.1002/Chem.201303410 |
0.354 |
|
| 2013 |
Weller SK, Kuchta RD. The DNA helicase-primase complex as a target for herpes viral infection. Expert Opinion On Therapeutic Targets. 17: 1119-32. PMID 23930666 DOI: 10.1517/14728222.2013.827663 |
0.369 |
|
| 2013 |
Olson AC, Patro JN, Urban M, Kuchta RD. The energetic difference between synthesis of correct and incorrect base pairs accounts for highly accurate DNA replication. Journal of the American Chemical Society. 135: 1205-8. PMID 23316816 DOI: 10.1021/Ja309866M |
0.664 |
|
| 2011 |
Lund TJ, Cavanaugh NA, Joubert N, Urban M, Patro JN, Hocek M, Kuchta RD. B family DNA polymerases asymmetrically recognize pyrimidines and purines. Biochemistry. 50: 7243-50. PMID 21761848 DOI: 10.1021/Bi2006916 |
0.761 |
|
| 2011 |
Stengel G, Purse BW, Kuchta RD. Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine analogs. Analytical Biochemistry. 416: 53-60. PMID 21600183 DOI: 10.1016/J.Ab.2011.04.033 |
0.398 |
|
| 2011 |
Chen Y, Bai P, Mackay S, Korza G, Carson JH, Kuchta RD, Weller SK. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. Journal of Virology. 85: 968-78. PMID 21068246 DOI: 10.1128/Jvi.01690-10 |
0.534 |
|
| 2011 |
Stengel G, Kuchta RD. Coordinated leading and lagging strand DNA synthesis by using the herpes simplex virus 1 replication complex and minicircle DNA templates. Journal of Virology. 85: 957-67. PMID 21068232 DOI: 10.1128/Jvi.01688-10 |
0.564 |
|
| 2010 |
Kuchta RD. Nucleotide Analogues as Probes for DNA and RNA Polymerases. Current Protocols in Chemical Biology. 2: 111-124. PMID 21822500 DOI: 10.1002/9780470559277.Ch090203 |
0.455 |
|
| 2010 |
Olson AC, Rosenblum E, Kuchta RD. Regulation of influenza RNA polymerase activity and the switch between replication and transcription by the concentrations of the vRNA 5' end, the cap source, and the polymerase. Biochemistry. 49: 10208-15. PMID 21033726 DOI: 10.1021/Bi101011J |
0.598 |
|
| 2010 |
Johnson LM, Hansen RR, Urban M, Kuchta RD, Bowman CN. Photoinitiator nucleotide for quantifying nucleic Acid hybridization. Biomacromolecules. 11: 1133-8. PMID 20337438 DOI: 10.1021/Bm901441V |
0.441 |
|
| 2010 |
Stengel G, Urban M, Purse BW, Kuchta RD. Incorporation of the fluorescent ribonucleotide analogue tCTP by T7 RNA polymerase. Analytical Chemistry. 82: 1082-9. PMID 20067253 DOI: 10.1021/Ac902456N |
0.38 |
|
| 2010 |
Urban M, Joubert N, Purse BW, Hocek M, Kuchta RD. Mechanisms by which human DNA primase chooses to polymerize a nucleoside triphosphate. Biochemistry. 49: 727-35. PMID 20030400 DOI: 10.1021/Bi9019516 |
0.567 |
|
| 2010 |
Kuchta RD, Stengel G. Mechanism and evolution of DNA primases. Biochimica Et Biophysica Acta. 1804: 1180-9. PMID 19540940 DOI: 10.1016/J.Bbapap.2009.06.011 |
0.58 |
|
| 2009 |
Urban M, Joubert N, Hocek M, Alexander RE, Kuchta RD. Herpes simplex virus-1 DNA primase: a remarkably inaccurate yet selective polymerase. Biochemistry. 48: 10866-81. PMID 19835416 DOI: 10.1021/Bi901476K |
0.38 |
|
| 2009 |
Stengel G, Urban M, Purse BW, Kuchta RD. High density labeling of polymerase chain reaction products with the fluorescent base analogue tCo. Analytical Chemistry. 81: 9079-85. PMID 19810708 DOI: 10.1021/Ac9017555 |
0.522 |
|
| 2009 |
Cavanaugh NA, Ramirez-Aguilar KA, Urban M, Kuchta RD. Herpes simplex virus-1 helicase-primase: roles of each subunit in DNA binding and phosphodiester bond formation. Biochemistry. 48: 10199-207. PMID 19788334 DOI: 10.1021/Bi9010144 |
0.807 |
|
| 2009 |
Patro JN, Urban M, Kuchta RD. Interaction of human DNA polymerase alpha and DNA polymerase I from Bacillus stearothermophilus with hypoxanthine and 8-oxoguanine nucleotides. Biochemistry. 48: 8271-8. PMID 19642651 DOI: 10.1021/Bi900777S |
0.511 |
|
| 2009 |
Stengel G, Purse BW, Wilhelmsson LM, Urban M, Kuchta RD. Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment. Biochemistry. 48: 7547-55. PMID 19580325 DOI: 10.1021/Bi9006995 |
0.566 |
|
| 2009 |
Trostler M, Delier A, Beckman J, Urban M, Patro JN, Spratt TE, Beese LS, Kuchta RD. Discrimination between right and wrong purine dNTPs by DNA polymerase I from Bacillus stearothermophilus. Biochemistry. 48: 4633-41. PMID 19348507 DOI: 10.1021/Bi900104N |
0.76 |
|
| 2009 |
Cavanaugh NA, Urban M, Beckman J, Spratt TE, Kuchta RD. Identifying the features of purine dNTPs that allow accurate and efficient DNA replication by herpes simplex virus I DNA polymerase. Biochemistry. 48: 3554-64. PMID 19166354 DOI: 10.1021/Bi8022202 |
0.763 |
|
| 2009 |
Patro JN, Urban M, Kuchta RD. Role of the 2-amino group of purines during dNTP polymerization by human DNA polymerase alpha. Biochemistry. 48: 180-9. PMID 19072331 DOI: 10.1021/Bi801823Z |
0.527 |
|
| 2009 |
Cavanaugh NA, Kuchta RD. Initiation of new DNA strands by the herpes simplex virus-1 primase-helicase complex and either herpes DNA polymerase or human DNA polymerase alpha. The Journal of Biological Chemistry. 284: 1523-32. PMID 19028696 DOI: 10.1074/Jbc.M805476200 |
0.811 |
|
| 2008 |
Keller KE, Cavanaugh N, Kuchta RD. Interaction of herpes primase with the sugar of a NTP. Biochemistry. 47: 8977-84. PMID 18672908 DOI: 10.1021/Bi8008467 |
0.77 |
|
| 2008 |
Cavanaugh N, Trostler M, Patro J, Beckman J, Kuchta RD. Mechanisms by which DNA polymerases discriminate between right and wrong dNTPs Collection of Czechoslovak Chemical Communications. 10: 186-190. DOI: 10.1135/Css200810186 |
0.78 |
|
| 2007 |
Dankbar DM, Dawson ED, Mehlmann M, Moore CL, Smagala JA, Shaw MW, Cox NJ, Kuchta RD, Rowlen KL. Diagnostic microarray for influenza B viruses. Analytical Chemistry. 79: 2084-90. PMID 17326602 DOI: 10.1021/Ac061960S |
0.316 |
|
| 2007 |
Blair RH, Rosenblum ES, Dawson ED, Kuchta RD, Kuck LR, Rowlen KL. Real-time quantification of RNA polymerase activity using a "broken beacon". Analytical Biochemistry. 362: 213-20. PMID 17222795 DOI: 10.1016/J.Ab.2006.12.012 |
0.339 |
|
| 2007 |
Beckman J, Kincaid K, Hocek M, Spratt T, Engels J, Cosstick R, Kuchta RD. Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity. Biochemistry. 46: 448-60. PMID 17209555 DOI: 10.1021/Bi061243S |
0.77 |
|
| 2007 |
Dawson ED, Moore CL, Dankbar DM, Mehlmann M, Townsend MB, Smagala JA, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Identification of A/H5N1 influenza viruses using a single gene diagnostic microarray. Analytical Chemistry. 79: 378-84. PMID 17194164 DOI: 10.1021/Ac061920O |
0.3 |
|
| 2006 |
Kincaid K, Kuchta RD. A mass spectrometry-based approach for identifying novel DNA polymerase substrates from a pool of dNTP analogues. Nucleic Acids Research. 34: e109. PMID 16945949 DOI: 10.1093/Nar/Gkl632 |
0.52 |
|
| 2006 |
Townsend MB, Dawson ED, Mehlmann M, Smagala JA, Dankbar DM, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance. Journal of Clinical Microbiology. 44: 2863-71. PMID 16891504 DOI: 10.1128/Jcm.00134-06 |
0.3 |
|
| 2006 |
Mehlmann M, Dawson ED, Townsend MB, Smagala JA, Moore CL, Smith CB, Cox NJ, Kuchta RD, Rowlen KL. Robust sequence selection method used to develop the FluChip diagnostic microarray for influenza virus. Journal of Clinical Microbiology. 44: 2857-62. PMID 16891503 DOI: 10.1128/Jcm.00135-06 |
0.328 |
|
| 2006 |
Richards OC, Spagnolo JF, Lyle JM, Vleck SE, Kuchta RD, Kirkegaard K. Intramolecular and intermolecular uridylylation by poliovirus RNA-dependent RNA polymerase. Journal of Virology. 80: 7405-15. PMID 16840321 DOI: 10.1128/Jvi.02533-05 |
0.357 |
|
| 2006 |
Stivers JT, Kuchta RD. Introduction: DNA damage and repair Chemical Reviews. 106: 213-214. DOI: 10.1021/Cr0404949 |
0.457 |
|
| 2005 |
Ramirez-Aguilar KA, Moore CL, Kuchta RD. Herpes simplex virus 1 primase employs watson-crick hydrogen bonding to identify cognate nucleoside triphosphates. Biochemistry. 44: 15585-93. PMID 16300408 DOI: 10.1021/Bi0513711 |
0.388 |
|
| 2005 |
Mehlmann M, Townsend MB, Stears RL, Kuchta RD, Rowlen KL. Optimization of fragmentation conditions for microarray analysis of viral RNA. Analytical Biochemistry. 347: 316-23. PMID 16266686 DOI: 10.1016/J.Ab.2005.09.036 |
0.353 |
|
| 2005 |
Kincaid K, Beckman J, Zivkovic A, Halcomb RL, Engels JW, Kuchta RD. Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha. Nucleic Acids Research. 33: 2620-8. PMID 15879351 DOI: 10.1093/Nar/Gki563 |
0.776 |
|
| 2004 |
Richardson KA, Vega TP, Richardson FC, Moore CL, Rohloff JC, Tomkinson B, Bendele RA, Kuchta RD. Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase. Biochemical Pharmacology. 68: 2337-46. PMID 15548380 DOI: 10.1016/J.Bcp.2004.07.042 |
0.458 |
|
| 2004 |
Moore CL, Zivkovic A, Engels JW, Kuchta RD. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 43: 12367-74. PMID 15379576 DOI: 10.1021/Bi0490791 |
0.485 |
|
| 2004 |
Ramirez-Aguilar KA, Kuchta RD. Herpes simplex virus-1 primase: a polymerase with extraordinarily low fidelity. Biochemistry. 43: 9084-91. PMID 15248765 DOI: 10.1021/Bi049335+ |
0.495 |
|
| 2004 |
Ramirez-Aguilar KA, Kuchta RD. Mechanism of primer synthesis by the herpes simplex virus 1 helicase-primase. Biochemistry. 43: 1754-62. PMID 14769053 DOI: 10.1021/Bi035519X |
0.385 |
|
| 2003 |
Chiaramonte M, Moore CL, Kincaid K, Kuchta RD. Facile polymerization of dNTPs bearing unnatural base analogues by DNA polymerase alpha and Klenow fragment (DNA polymerase I). Biochemistry. 42: 10472-81. PMID 12950174 DOI: 10.1021/Bi034763L |
0.709 |
|
| 2002 |
Ramirez-Aguilar KA, Low-Nam NA, Kuchta RD. Key role of template sequence for primer synthesis by the herpes simplex virus 1 helicase-primase. Biochemistry. 41: 14569-79. PMID 12463757 DOI: 10.1021/Bi026680V |
0.367 |
|
| 2002 |
Moore CL, Chiaramonte M, Higgins T, Kuchta RD. Synthesis of nucleotide analogues that potently and selectively inhibit human DNA primase. Biochemistry. 41: 14066-75. PMID 12437364 DOI: 10.1021/Bi026468R |
0.689 |
|
| 2002 |
Zerbe LK, Kuchta RD. The p58 subunit of human DNA primase is important for primer initiation, elongation, and counting. Biochemistry. 41: 4891-900. PMID 11939784 DOI: 10.1021/Bi016030B |
0.41 |
|
| 2001 |
Chiaramonte M, Koviach JL, Moore C, Iyer VV, Wagner CR, Halcomb RL, Miller W, Melançon P, Kuchta RD. Inhibition of CMP-sialic acid transport into Golgi vesicles by nucleoside monophosphates. Biochemistry. 40: 14260-7. PMID 11714280 DOI: 10.1021/Bi011262W |
0.554 |
|
| 2000 |
Arezi B, Kuchta RD. Eukaryotic DNA primase Trends in Biochemical Sciences. 25: 572-576. PMID 11084371 DOI: 10.1016/S0968-0004(00)01680-7 |
0.549 |
|
| 2000 |
Steet RA, Melancon P, Kuchta RD. 3'-Azidothymidine potently inhibits the biosynthesis of highly branched N-linked oligosaccharides and poly-N-acetyllactosamine chains in cells. The Journal of Biological Chemistry. 275: 26812-20. PMID 10842182 DOI: 10.1074/Jbc.M004038200 |
0.322 |
|
| 2000 |
Richardson FC, Kuchta RD, Mazurkiewicz A, Richardson KA. Polymerization of 2'-fluoro- and 2'-O-methyl-dNTPs by human DNA polymerase alpha, polymerase gamma, and primase. Biochemical Pharmacology. 59: 1045-52. PMID 10704933 DOI: 10.1016/S0006-2952(99)00414-1 |
0.433 |
|
| 1999 |
Zerbe LK, Goodman MF, Efrati E, Kuchta RD. Abasic template lesions are strong chain terminators for DNA primase but not for DNA polymerase α during the synthesis of new DNA strands Biochemistry. 38: 12908-12914. PMID 10504262 DOI: 10.1021/Bi991075M |
0.421 |
|
| 1999 |
Arezi B, Kirk BW, Copeland WC, Kuchta RD. Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: Implications for the role of the p58 subunit Biochemistry. 38: 12899-12907. PMID 10504261 DOI: 10.1021/Bi9908991 |
0.451 |
|
| 1999 |
Kirk BW, Kuchta RD. Human DNA primase: Anion inhibition, manganese stimulation, and their effects on in vitro start-site selection Biochemistry. 38: 10126-10134. PMID 10433721 DOI: 10.1021/Bi990351U |
0.385 |
|
| 1999 |
Kirk BW, Kuchta RD. Arg304 of human DNA primase is a key contributor to catalysis and NTP binding: Primase and the family X polymerases share significant sequence homology Biochemistry. 38: 7727-7736. PMID 10387012 DOI: 10.1021/Bi990247C |
0.382 |
|
| 1997 |
Kirk BW, Harrington C, Perrino FW, Kuchta RD. Eucaryotic DNA primase does not prefer to synthesize primers at pyrimidine rich DNA sequences when nucleoside triphosphates are present at concentrations found in whole cells Biochemistry. 36: 6725-6731. PMID 9184153 DOI: 10.1021/Bi962630C |
0.527 |
|
| 1997 |
Kuchta RD. Inhibition of DNA primase by 9-β-D-arabinofuranosyladenosine triphosphate Biochemistry. 30: 797-803. PMID 1703021 DOI: 10.1021/Bi00217A033 |
0.391 |
|
| 1996 |
Kuchta RD. Isotopic assays of viral polymerases and related proteins Methods in Enzymology. 275: 241-257. PMID 9026642 DOI: 10.1016/S0076-6879(96)75016-4 |
0.31 |
|
| 1996 |
Traynor AJ, Hall ET, Walker G, Miller WH, Melançon P, Kuchta RD. Inhibition of UDP-N-acetylglucosamine import into Golgi membranes by nucleoside monophosphates. Journal of Medicinal Chemistry. 39: 2894-9. PMID 8709123 DOI: 10.1021/Jm960175C |
0.359 |
|
| 1995 |
Ilsley DD, Lee SH, Miller WH, Kuchta RD. Acyclic guanosine analogs inhibit DNA polymerases alpha, delta, and epsilon with very different potencies and have unique mechanisms of action. Biochemistry. 34: 2504-10. PMID 7873530 DOI: 10.1021/Bi00008A014 |
0.461 |
|
| 1995 |
Catalane CE, Kuchta RD. Inactivation of DNA polymerase α-primase by acrolein: Loss of activity depends on the DNA substrate Biochemical and Biophysical Research Communications. 214: 971-977. PMID 7575571 DOI: 10.1006/bbrc.1995.2381 |
0.412 |
|
| 1995 |
Yan JP, Ilsley DD, Frohlick C, Steet R, Hall ET, Kuchta RD, Melançon P. 3′-Azidothymidine (Zidovudine) inhibits glycosylation and dramatically alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations Journal of Biological Chemistry. 270: 22836-22841. PMID 7559416 DOI: 10.1074/Jbc.270.39.22836 |
0.396 |
|
| 1995 |
Thompson HC, Kuchta RD. Arabinofuranosyl nucleotides are not chain-terminators during initiation of new strands of DNA by DNA polymerase alpha-primase. Biochemistry. 34: 11198-203. PMID 7545435 DOI: 10.1021/Bi00035A027 |
0.532 |
|
| 1995 |
Thompson HC, Sheaff RJ, Kuchta RD. Interactions of calf thymus DNA polymerase α with primer/templates Nucleic Acids Research. 23: 4109-4115. PMID 7479073 DOI: 10.1093/Nar/23.20.4109 |
0.491 |
|
| 1994 |
Kuchta RD. Calf thymus DNA polymerase α-primase: "communication" and primer-template movement between the two active sites Biochemistry®. 33: 2247-2254. PMID 8117681 DOI: 10.1021/Bi00174A035 |
0.491 |
|
| 1994 |
Sheaff RJ, Kuchta RD. Misincorporation of nucleotides by calf thymus DNA primase and elongation of primers containing multiple noncognate nucleotides by DNA polymerase α Journal of Biological Chemistry. 269: 19225-19231. PMID 8034683 |
0.464 |
|
| 1993 |
Kuchta RD. DNA polymerase ε: Aphidicolin inhibition and the relationship between polymerase and exonuclease activity Biochemistry. 32: 8568-8574. PMID 8395209 DOI: 10.1021/Bi00084A025 |
0.566 |
|
| 1993 |
Sheaff RJ, Kuchta RD. Mechanism of calf thymus DNA primase: Slow initiation, rapid polymerization, and intelligent termination Biochemistry. 32: 3027-3037. PMID 7681326 DOI: 10.1021/Bi00063A014 |
0.524 |
|
| 1992 |
Kuchta RD, Ilsley D, Kravig KD, Schubert S, Harris B. Inhibition of DNA primase and polymerase alpha by arabinofuranosylnucleoside triphosphates and related compounds. Biochemistry. 31: 4720-4728. PMID 1581321 DOI: 10.1021/Bi00134A027 |
0.574 |
|
| 1992 |
Kuchta RD, Ilsley D, Kravig KD, Schubert S, Harris B. Inhibition of DNA primase and polymerase α by arabinofuranosylnucleoside triphosphates and related compounds Biochemistry. 31: 4720-4728. |
0.451 |
|
| 1991 |
Eger BT, Kuchta RD, Carroll SS, Benkovic PA, Dahlberg ME, Joyce CM, Benkovic SJ. Mechanism of DNA replication fidelity for three mutants of DNA polymerase I: Klenow fragment KF(exo+), KF(polA5), and KF(exo-) Biochemistry. 30: 1441-1448. PMID 1991125 DOI: 10.1021/Bi00219A039 |
0.565 |
|
| 1991 |
Sheaff R, Ilsley D, Kuchta R. Mechanism of DNA polymerase alpha inhibition by aphidicolin. Biochemistry. 30: 8590-7. PMID 1909569 DOI: 10.1021/Bi00099A014 |
0.496 |
|
| 1990 |
Kuchta RD, Reid B, Chang LMS. DNA primase. Processivity and the primase to polymerase α activity switch Journal of Biological Chemistry. 265: 16158-16165. PMID 2398049 |
0.324 |
|
| 1988 |
Kuchta RD, Cowart M, Allen D, Benkovic SJ. Kinetic and structural investigations of the replicative fidelity of the Klenow fragment Biochemical Society Transactions. 16: 947-949. PMID 3224760 DOI: 10.1042/Bst0160947 |
0.321 |
|
| 1988 |
Kuchta RD, Benkovic P, Benkovic SJ. Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity Biochemistry. 27: 6716-6725. PMID 3058205 DOI: 10.1021/Bi00418A012 |
0.556 |
|
| 1987 |
Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow) Biochemistry. 26: 8410-8417. PMID 3327522 DOI: 10.1021/Bi00399A057 |
0.516 |
|
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