Fred W. Keeley - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Biochemistry

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Reichheld SE, Muiznieks LD, Lu R, Sharpe S, Keeley FW. Sequence variants of human tropoelastin affecting assembly, structural characteristics and functional properties of polymeric elastin in health and disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 31254613 DOI: 10.1016/J.Matbio.2019.06.010  0.5
2019 Srivastava A, Xue Z, Muiznieks LD, Keeley FW, Pomes R. Solvent Effects on the Self-Assembly and Mechanical Properties of Elastin-Like Peptides Biophysical Journal. 116: 202a. DOI: 10.1016/J.Bpj.2018.11.1115  0.409
2018 Muiznieks LD, Sharpe S, Pomès R, Keeley FW. Role of Liquid-Liquid Phase Separation in Assembly of Elastin and Other Extracellular Matrix Proteins. Journal of Molecular Biology. PMID 29886015 DOI: 10.1016/J.Jmb.2018.06.010  0.412
2017 Reichheld SE, Muiznieks LD, Keeley FW, Sharpe S. Direct observation of structure and dynamics during phase separation of an elastomeric protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 28507126 DOI: 10.1073/Pnas.1701877114  0.449
2017 Muiznieks LD, Keeley FW, Pomès R. Controlling the Biophysical Properties and Functionality of Phase-Separated Elastin-Based Droplets through Amino Acid Sequence Mutations Biophysical Journal. 112: 480a-481a. DOI: 10.1016/J.Bpj.2016.11.2601  0.362
2016 Miao M, Reichheld SE, Muiznieks LD, Sitarz EE, Sharpe S, Keeley FW. Single Nucleotide Polymorphisms and Domain/Splice Variants Modulate Assembly and Elastomeric Properties of Human Elastin. Implications for Tissue Specificity and Durability of Elastic Tissue. Biopolymers. PMID 27997981 DOI: 10.1002/Bip.23007  0.475
2016 Muiznieks LD, Keeley FW. Phase separation and mechanical properties of an elastomeric biomaterial from spider wrapping silk and elastin block copolymers. Biopolymers. PMID 27272259 DOI: 10.1002/Bip.22888  0.414
2016 Muiznieks LD, Miao M, Sitarz EE, Keeley FW. Contribution of domain 30 of tropoelastin to elastic fiber formation and material elasticity. Biopolymers. 105: 267-75. PMID 26763595 DOI: 10.1002/bip.22804  0.353
2016 Muiznieks LD, Keeley FW. Biomechanical Design of Elastic Protein Biomaterials: A Balance of Protein Structure and Conformational Disorder Acs Biomaterials Science & Engineering. 3: 661-679. DOI: 10.1021/Acsbiomaterials.6B00469  0.393
2015 Muiznieks LD, Reichheld SE, Sitarz EE, Miao M, Keeley FW. Proline-poor hydrophobic domains modulate the assembly and material properties of polymeric elastin. Biopolymers. 103: 563-73. PMID 25924982 DOI: 10.1002/Bip.22663  0.523
2014 Heinz A, Schräder CU, Baud S, Keeley FW, Mithieux SM, Weiss AS, Neubert RH, Schmelzer CE. Molecular-level characterization of elastin-like constructs and human aortic elastin. Matrix Biology : Journal of the International Society For Matrix Biology. 38: 12-21. PMID 25068896 DOI: 10.1016/J.Matbio.2014.07.006  0.366
2014 Muiznieks LD, Cirulis JT, van der Horst A, Reinhardt DP, Wuite GJ, Pomès R, Keeley FW. Modulated growth, stability and interactions of liquid-like coacervate assemblies of elastin. Matrix Biology : Journal of the International Society For Matrix Biology. 36: 39-50. PMID 24727034 DOI: 10.1016/J.Matbio.2014.03.008  0.397
2014 Reichheld SE, Muiznieks LD, Stahl R, Simonetti K, Sharpe S, Keeley FW. Conformational transitions of the cross-linking domains of elastin during self-assembly. The Journal of Biological Chemistry. 289: 10057-68. PMID 24550393 DOI: 10.1074/Jbc.M113.533893  0.482
2013 Miao M, Reichheld SE, Muiznieks LD, Huang Y, Keeley FW. Elastin binding protein and FKBP65 modulate in vitro self-assembly of human tropoelastin. Biochemistry. 52: 7731-41. PMID 24106871 DOI: 10.1021/Bi400760F  0.478
2013 Miao M, Sitarz E, Bellingham CM, Won E, Muiznieks LD, Keeley FW. Sequence and domain arrangements influence mechanical properties of elastin-like polymeric elastomers. Biopolymers. 99: 392-407. PMID 23529691 DOI: 10.1002/Bip.22192  0.806
2013 Heinz A, Ruttkies CKH, Jahreis G, Schräder CU, Wichapong K, Sippl W, Keeley FW, Neubert RHH, Schmelzer CEH. In vitro cross-linking of elastin peptides and molecular characterization of the resultant biomaterials Biochimica Et Biophysica Acta - General Subjects. 1830: 2994-3004. PMID 23375722 DOI: 10.1016/J.Bbagen.2013.01.014  0.351
2013 Muiznieks LD, Keeley FW. Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective. Biochimica Et Biophysica Acta. 1832: 866-75. PMID 23220448 DOI: 10.1016/J.Bbadis.2012.11.022  0.401
2013 Muiznieks LD, Sitarz E, Reichheld S, Miao M, Keeley FW. Sequence and Structural Modulators of Elastin Assembly and Mechanical Properties Biophysical Journal. 104: 49a. DOI: 10.1016/J.Bpj.2012.11.312  0.502
2013 Miao M, Sitarz E, Bellingham CM, Won E, Muiznieks LD, Keeley FW. Erratum: “Sequence and domain arrangements influence mechanical properties of elastin-like polymeric elastomers,” Biopolymers 99, 392-407 (2013) Biopolymers. 101: 129-129. DOI: 10.1002/Bip.22414  0.767
2012 He D, Miao M, Sitarz EE, Muiznieks LD, Reichheld S, Stahl RJ, Keeley FW, Parkinson J. Polymorphisms in the human tropoelastin gene modify in vitro self-assembly and mechanical properties of elastin-like polypeptides. Plos One. 7: e46130. PMID 23049958 DOI: 10.1371/Journal.Pone.0046130  0.423
2011 Yeo GC, Keeley FW, Weiss AS. Coacervation of tropoelastin. Advances in Colloid and Interface Science. 167: 94-103. PMID 21081222 DOI: 10.1016/J.Cis.2010.10.003  0.443
2011 van der Horst A, Miao M, Forde NR, Keeley FW, Wuite GJ. Exploring the Mechanics and Organization of Elastin Coacervate Structures Using Micromanipulation Tools Biophysical Journal. 100: 62a. DOI: 10.1016/J.Bpj.2010.12.535  0.446
2010 Muiznieks LD, Keeley FW. Proline periodicity modulates the self-assembly properties of elastin-like polypeptides. The Journal of Biological Chemistry. 285: 39779-89. PMID 20947499 DOI: 10.1016/J.Bpj.2010.12.1299  0.487
2010 Akhtar K, Broekelmann TJ, Miao M, Keeley FW, Starcher BC, Pierce RA, Mecham RP, Adair-Kirk TL. Oxidative and nitrosative modifications of tropoelastin prevent elastic fiber assembly in vitro. The Journal of Biological Chemistry. 285: 37396-404. PMID 20847053 DOI: 10.1074/Jbc.M110.126789  0.301
2010 Cirulis JT, Keeley FW. Kinetics and morphology of self-assembly of an elastin-like polypeptide based on the alternating domain arrangement of human tropoelastin. Biochemistry. 49: 5726-33. PMID 20527981 DOI: 10.1021/Bi100468V  0.506
2010 Hrabchak C, Rouleau J, Moss I, Woodhouse K, Akens M, Bellingham C, Keeley F, Dennis M, Yee A. Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits. Acta Biomaterialia. 6: 2108-15. PMID 20026437 DOI: 10.1016/J.Actbio.2009.12.034  0.772
2010 Hubmacher D, Cirulis JT, Miao M, Keeley FW, Reinhardt DP. Functional consequences of homocysteinylation of the elastic fiber proteins fibrillin-1 and tropoelastin. The Journal of Biological Chemistry. 285: 1188-98. PMID 19889633 DOI: 10.1074/Jbc.M109.021246  0.375
2010 Downing BP, van der Horst A, Miao M, Keeley FW, Forde NR. Probing the Mechanical Properties of Single Scleroproteins with Optical Tweezers Biophysical Journal. 98: 593a. DOI: 10.1016/J.Bpj.2009.12.3225  0.408
2009 Miao M, Stahl RJ, Petersen LF, Reintsch WE, Davis EC, Keeley FW. Characterization of an unusual tropoelastin with truncated C-terminus in the frog. Matrix Biology : Journal of the International Society For Matrix Biology. 28: 432-41. PMID 19638308 DOI: 10.1016/J.Matbio.2009.07.003  0.417
2009 Cirulis JT, Keeley FW, James DF. Viscoelastic properties and gelation of an elastin-like polypeptide Journal of Rheology. 53: 1215-1228. DOI: 10.1122/1.3177005  0.39
2008 Cirulis JT, Bellingham CM, Davis EC, Hubmacher D, Reinhardt DP, Mecham RP, Keeley FW. Fibrillins, fibulins, and matrix-associated glycoprotein modulate the kinetics and morphology of in vitro self-assembly of a recombinant elastin-like polypeptide. Biochemistry. 47: 12601-13. PMID 18973305 DOI: 10.1021/Bi8005384  0.794
2007 Hill CH, Ashwell CM, Nolin SJ, Keeley F, Billingham C, Hinek A, Starcher B. Dietary iron deficiency compromises normal development of elastic fibers in the aorta and lungs of chicks. The Journal of Nutrition. 137: 1895-900. PMID 17634261 DOI: 10.1093/Jn/137.8.1895  0.303
2007 He D, Chung M, Chan E, Alleyne T, Ha KC, Miao M, Stahl RJ, Keeley FW, Parkinson J. Comparative genomics of elastin: Sequence analysis of a highly repetitive protein. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 524-40. PMID 17628459 DOI: 10.1016/J.Matbio.2007.05.005  0.349
2007 Miao M, Bruce AE, Bhanji T, Davis EC, Keeley FW. Differential expression of two tropoelastin genes in zebrafish. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 115-24. PMID 17112714 DOI: 10.1016/J.Matbio.2006.09.011  0.323
2007 Vieth S, Bellingham CM, Keeley FW, Hodge SM, Rousseau D. Microstructural and tensile properties of elastin-based polypeptides crosslinked with genipin and pyrroloquinoline quinone. Biopolymers. 85: 199-206. PMID 17066474 DOI: 10.1002/Bip.20619  0.769
2006 Rauscher S, Baud S, Miao M, Keeley FW, Pomès R. Proline and glycine control protein self-organization into elastomeric or amyloid fibrils. Structure (London, England : 1993). 14: 1667-76. PMID 17098192 DOI: 10.1016/J.Str.2006.09.008  0.402
2006 Chung MI, Miao M, Stahl RJ, Chan E, Parkinson J, Keeley FW. Sequences and domain structures of mammalian, avian, amphibian and teleost tropoelastins: Clues to the evolutionary history of elastins. Matrix Biology : Journal of the International Society For Matrix Biology. 25: 492-504. PMID 16982180 DOI: 10.1016/J.Matbio.2006.08.258  0.431
2006 Kumashiro KK, Ho JP, Niemczura WP, Keeley FW. Cooperativity between the hydrophobic and cross-linking domains of elastin. The Journal of Biological Chemistry. 281: 23757-65. PMID 16777851 DOI: 10.1074/Jbc.M510833200  0.416
2005 Miao M, Cirulis JT, Lee S, Keeley FW. Structural determinants of cross-linking and hydrophobic domains for self-assembly of elastin-like polypeptides. Biochemistry. 44: 14367-75. PMID 16245953 DOI: 10.1021/Bi0510173  0.521
2005 Broekelmann TJ, Kozel BA, Ishibashi H, Werneck CC, Keeley FW, Zhang L, Mecham RP. Tropoelastin interacts with cell-surface glycosaminoglycans via its COOH-terminal domain. The Journal of Biological Chemistry. 280: 40939-47. PMID 16192266 DOI: 10.1074/Jbc.M507309200  0.311
2004 Woodhouse KA, Klement P, Chen V, Gorbet MB, Keeley FW, Stahl R, Fromstein JD, Bellingham CM. Investigation of recombinant human elastin polypeptides as non-thrombogenic coatings. Biomaterials. 25: 4543-53. PMID 15120499 DOI: 10.1016/J.Biomaterials.2003.11.043  0.738
2004 Bellingham CM, Keeley FW. Self-ordered polymerization of elastin-based biomaterials Current Opinion in Solid State and Materials Science. 8: 135-139. DOI: 10.1016/j.cossms.2004.01.007  0.786
2004 Bellingham CM, Lillie MA, Gosline JM, Woodhouse KA, Stahl R, Sitarz EE, Keeley FW. Recombinant human elastin polypeptides self-assemble into materials with elastin-like properties Transactions - 7th World Biomaterials Congress. 1005.  0.775
2003 Bellingham CM, Lillie MA, Gosline JM, Wright GM, Starcher BC, Bailey AJ, Woodhouse KA, Keeley FW. Recombinant human elastin polypeptides self-assemble into biomaterials with elastin-like properties. Biopolymers. 70: 445-55. PMID 14648756 DOI: 10.1002/Bip.10512  0.81
2003 Miao M, Bellingham CM, Stahl RJ, Sitarz EE, Lane CJ, Keeley FW. Sequence and structure determinants for the self-aggregation of recombinant polypeptides modeled after human elastin. The Journal of Biological Chemistry. 278: 48553-62. PMID 14500713 DOI: 10.1074/Jbc.M308465200  0.802
2003 Visconti RP, Barth JL, Keeley FW, Little CD. Codistribution analysis of elastin and related fibrillar proteins in early vertebrate development. Matrix Biology : Journal of the International Society For Matrix Biology. 22: 109-21. PMID 12782138 DOI: 10.1016/S0945-053X(03)00014-3  0.398
2002 Keeley FW, Bellingham CM, Woodhouse KA. Elastin as a self-organizing biomaterial: use of recombinantly expressed human elastin polypeptides as a model for investigations of structure and self-assembly of elastin. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 357: 185-9. PMID 11911775 DOI: 10.1098/Rstb.2001.1027  0.809
2001 Bellingham CM, Woodhouse KA, Robson P, Rothstein SJ, Keeley FW. Self-aggregation characteristics of recombinantly expressed human elastin polypeptides. Biochimica Et Biophysica Acta. 1550: 6-19. PMID 11738083 DOI: 10.1016/S0167-4838(01)00262-X  0.802
2001 Wright GM, Keeley FW, Robson P. The unusual cartilaginous tissues of jawless craniates, cephalochordates and invertebrates Cell and Tissue Research. 304: 165-174. PMID 11396711 DOI: 10.1007/S004410100374  0.384
2000 Robson P, Wright GM, Youson JH, Keeley FW. The structure and organization of lamprin genes: Multiple-copy genes with alternative splicing and convergent evolution with insect structural proteins Molecular Biology and Evolution. 17: 1739-1752. PMID 11070061 DOI: 10.1093/Oxfordjournals.Molbev.A026272  0.327
2000 Robson P, Wright GM, Keeley FW. Distinct non-collagen based cartilages comprising the endoskeleton of the Atlantic hagfish, Myxine glutinosa Anatomy and Embryology. 202: 281-290. PMID 11000279 DOI: 10.1007/S004290000113  0.375
2000 Hew Y, Lau C, Grzelczak Z, Keeley FW. Identification of a GA-rich sequence as a protein-binding site in the 3'-untranslated region of chicken elastin mRNA with a potential role in the developmental regulation of elastin mRNA stability. The Journal of Biological Chemistry. 275: 24857-64. PMID 10829024 DOI: 10.1074/Jbc.M002776200  0.753
1999 Hew Y, Grzelczak Z, Lau C, Keeley FW. Identification of a large region of secondary structure in the 3'-untranslated region of chicken elastin mRNA with implications for the regulation of mRNA stability. The Journal of Biological Chemistry. 274: 14415-21. PMID 10318866 DOI: 10.1074/Jbc.274.20.14415  0.752
1999 Keeley F, Wright G, Youson J, Robson P. Structural, functional and evolutionary relationships between elastin and non-collagenous matrix proteins of lower vertebrates and invertebrates Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 124: S35. DOI: 10.1016/S1095-6433(99)90136-8  0.353
1998 Robson P, Li F, Youson JH, Keeley FW. Identification and characterization of a serpin with differential expression during the life cycle of the sea lamprey Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 120: 253-263. PMID 9787795 DOI: 10.1016/S0305-0491(98)10015-9  0.321
1998 Filosa MF, Adam I, Robson P, Heinig JA, Smith K, Keeley FW, Youson JH. Partial clone of the gene for AS protein of the lamprey Petromyzon marinus, a member of the albumin supergene family whose expression is restricted to the larval and metamorphic phases of the life cycle. The Journal of Experimental Zoology. 282: 301-9. PMID 9755481 DOI: 10.1002/(Sici)1097-010X(19981015)282:3<301::Aid-Jez3>3.0.Co;2-Q  0.303
1997 Robson P, Wright GM, Youson JH, Keeley FW. A family of non-collagen-based cartilages in the skeleton of the sea lamprey, Petromyzon marinus Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology. 118: 71-78. DOI: 10.1016/S0305-0491(97)00026-6  0.378
1996 Strauss BH, Robinson R, Batchelor WB, Chisholm RJ, Ravi G, Natarajan MK, Logan RA, Mehta SR, Levy DE, Ezrin AM, Keeley FW. In vivo collagen turnover following experimental balloon angioplasty injury and the role of matrix metalloproteinases. Circulation Research. 79: 541-50. PMID 8781487 DOI: 10.1161/01.Res.79.3.541  0.326
1996 McBurney KM, Keeley FW, Kibenge FSB, Wright GM. Spatial and temporal distribution of lamprin mRNA during chondrogenesis of trabecular cartilage in the sea lamprey Anatomy and Embryology. 193: 419-426. PMID 8729960 DOI: 10.1007/Bf00185873  0.338
1995 Heinig JA, Keeley FW, Robson P, Sower SA, Youson JH. The appearance of proopiomelanocortin early in vertebrate evolution: cloning and sequencing of POMC from a Lamprey pituitary cDNA library. General and Comparative Endocrinology. 99: 137-44. PMID 8536922 DOI: 10.1006/Gcen.1995.1094  0.313
1995 Johnson DJ, Robson P, Hew Y, Keeley FW. Decreased elastin synthesis in normal development and in long-term aortic organ and cell cultures is related to rapid and selective destabilization of mRNA for elastin. Circulation Research. 77: 1107-13. PMID 7586222 DOI: 10.1161/01.Res.77.6.1107  0.741
1995 Hinek A, Keeley FW, Callahan J. Recycling of the 67-kDa elastin binding protein in arterial myocytes is imperative for secretion of tropoelastin Experimental Cell Research. 220: 312-324. PMID 7556439 DOI: 10.1006/Excr.1995.1321  0.342
1993 Hinek A, Rabinovitch M, Keeley F, Okamura-Oho Y, Callahan J. The 67-kD elastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of beta-galactosidase. The Journal of Clinical Investigation. 91: 1198-205. PMID 8383699 DOI: 10.1172/Jci116280  0.364
1993 Johnson DJ, Labourene J, Rabinovitch M, Keeley FW. Relative efficiency of incorporation of newly synthesized elastin and collagen into aorta, pulmonary artery and pulmonary vein of growing pigs Connective Tissue Research. 29: 213-221. PMID 8222648 DOI: 10.3109/03008209309016828  0.343
1993 Robson P, Wright GM, Sitarz E, Maiti A, Rawat M, Youson JH, Keeley FW. Characterization of lamprin, an unusual matrix protein from lamprey cartilage: Implications for evolution, structure, and assembly of elastin and other fibrillar proteins Journal of Biological Chemistry. 268: 1440-1447. PMID 7678258  0.373
1991 Hinek A, Mecham RP, Keeley F, Rabinovitch M. Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate Journal of Clinical Investigation. 88: 2083-2094. PMID 1661296 DOI: 10.1172/Jci115538  0.3
1985 Keeley FW, Sitarz EE. Identification and quantitation of α2-HS-glycoprotein in the mineralized matrix of calcified plaques of atherosclerotic human aorta Atherosclerosis. 55: 63-69. PMID 3924066 DOI: 10.1016/0021-9150(85)90166-2  0.306
1984 Wright GM, Keeley FW, Youson JH, Babineau DL. Cartilage in the Atlantic hagfish, Myxine glutinosa American Journal of Anatomy. 169: 407-424. PMID 6731333 DOI: 10.1002/Aja.1001690404  0.338
1983 Wright GM, Keeley FW, Youson JH. Lamprin: A new vertebrate protein comprising the major structural protein of adult lamprey cartilage Experientia. 39: 495-497. DOI: 10.1007/Bf01965172  0.322
1977 Keeley FW. The extraction and partial characterization of proteins released by decalcification from calcified human aortic plaques Bba - Protein Structure. 494: 384-394. PMID 410453 DOI: 10.1016/0005-2795(77)90167-2  0.306
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