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Odete A. Beirão da Cruz e Silva, PhD - Related publications

Medical Sciences University of Aveiro, Aveiro, Aveiro, Portugal 
Alzheimer's disease, Molecular Biomedicine
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Gupta SP, Patil VM. Recent Studies on Design and Development of Drugs Against Alzheimer's Disease (AD) Based on Inhibition of BACE-1 and Other AD-causative Agents. Current Topics in Medicinal Chemistry. PMID 32297584 DOI: 10.2174/1568026620666200416091623   
2020 Angelopoulou E, Paudel YN, Shaikh MF, Piperi C. Flotillin: A Promising Biomarker for Alzheimer's Disease. Journal of Personalized Medicine. 10. PMID 32225073 DOI: 10.3390/jpm10020020   
2020 Harris LD, Jasem S, Licchesi JDF. The Ubiquitin System in Alzheimer's Disease. Advances in Experimental Medicine and Biology. 1233: 195-221. PMID 32274758 DOI: 10.1007/978-3-030-38266-7_8   
2020 Shah H, Patel A, Parikh V, Nagani A, Bhimani B, Shah U, Bambharoliya T. The β-secretase enzyme BACE1: A biochemical enigma for Alzheimer's disease. Cns & Neurological Disorders Drug Targets. PMID 32452328 DOI: 10.2174/1871527319666200526144141   
2020 Klementieva O, Sandt C, Martinsson I, Kansiz M, Gouras GK, Borondics F. Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 1903004. PMID 32195099 DOI: 10.1002/advs.201903004   
2020 Park SY, Kang JY, Lee T, Nam D, Jeon CJ, Kim JB. Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. Cells. 9. PMID 32455709 DOI: 10.3390/cells9051275   
2020 Park SA, Han SM, Kim CE. New fluid biomarkers tracking non-amyloid-β and non-tau pathology in Alzheimer's disease. Experimental & Molecular Medicine. PMID 32284537 DOI: 10.1038/s12276-020-0418-9   
2020 Sato R, Vohra S, Yamamoto S, Suzuki K, Pavel K, Shulga S, Blume Y, Kurita N. Specific interactions between tau protein and curcumin derivatives: Molecular docking and ab initio molecular orbital simulations. Journal of Molecular Graphics & Modelling. 98: 107611. PMID 32276176 DOI: 10.1016/j.jmgm.2020.107611   
2020 Kawahara M, Kato-Negishi M, Tanaka KI. Amyloids: Regulators of Metal Homeostasis in the Synapse. Molecules (Basel, Switzerland). 25. PMID 32210005 DOI: 10.3390/molecules25061441   
2020 Fukumori A, Feilen LP, Steiner H. Substrate recruitment by γ-secretase. Seminars in Cell & Developmental Biology. PMID 32331992 DOI: 10.1016/j.semcdb.2020.03.006   
2020 Hicks DA, Jones AC, Pickering-Brown SM, Hooper NM. The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43. Bioscience Reports. PMID 32301481 DOI: 10.1042/BSR20200435   
2020 Chae CW, Lee HJ, Choi GE, Jung YH, Kim JS, Lim JR, Kim SY, Hwang IK, Seong JK, Han HJ. High glucose-mediated PICALM and mTORC1 modulate processing of amyloid precursor protein via endosomal abnormalities. British Journal of Pharmacology. PMID 32436237 DOI: 10.1111/bph.15131   
2020 Kwon S, Iba M, Kim C, Masliah E. Immunotherapies for Aging-Related Neurodegenerative Diseases-Emerging Perspectives and New Targets. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 32347461 DOI: 10.1007/s13311-020-00853-2   
2020 Curtis ME, Yu D, Praticò D. Dysregulation of the retromer complex system in Down syndrome. Annals of Neurology. PMID 32320094 DOI: 10.1002/ana.25752   
2020 Kou X, Chen D, Chen N. The Regulation of microRNAs in Alzheimer's Disease. Frontiers in Neurology. 11: 288. PMID 32362867 DOI: 10.3389/fneur.2020.00288   
2020 Johnson ECB, Dammer EB, Duong DM, Ping L, Zhou M, Yin L, Higginbotham LA, Guajardo A, White B, Troncoso JC, Thambisetty M, Montine TJ, Lee EB, Trojanowski JQ, Beach TG, et al. Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation. Nature Medicine. PMID 32284590 DOI: 10.1038/s41591-020-0815-6   
2020 Qi B, Yang Y, Cheng Y, Sun D, Wang X, Khanna R, Ju W. Nasal delivery of a CRMP2-derived CBD3 adenovirus improves cognitive function and pathology in APP/PS1 transgenic mice. Molecular Brain. 13: 58. PMID 32272942 DOI: 10.1186/s13041-020-00596-3   
2020 Gutierrez E, Lütjohann D, Kerksiek A, Fabiano M, Oikawa N, Kuerschner L, Thiele C, Walter J. Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism. Life Science Alliance. 3. PMID 32354700 DOI: 10.26508/lsa.201900521   
2020 Malmberg M, Malm T, Gustafsson O, Sturchio A, Graff C, Espay AJ, Wright AP, El Andaloussi S, Lindén A, Ezzat K. Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology. Frontiers in Neuroscience. 14: 256. PMID 32372895 DOI: 10.3389/fnins.2020.00256   
2020 Díaz-Caballero M, Navarro S, Ventura S. Soluble Assemblies in the Fibrillation Pathway of Prion-Inspired Artificial Functional Amyloids are Highly Cytotoxic. Biomacromolecules. PMID 32227922 DOI: 10.1021/acs.biomac.0c00271   
2020 Gee MS, Son SH, Jeon SH, Do J, Kim N, Ju YJ, Lee SJ, Chung EK, Inn KS, Kim NJ, Lee JK. A selective p38α/β MAPK inhibitor alleviates neuropathology and cognitive impairment, and modulates microglia function in 5XFAD mouse. Alzheimer's Research & Therapy. 12: 45. PMID 32317025 DOI: 10.1186/s13195-020-00617-2   
2020 Taglialegna A, Matilla-Cuenca L, Dorado-Morales P, Navarro S, Ventura S, Garnett JA, Lasa I, Valle J. The biofilm-associated surface protein Esp of Enterococcus faecalis forms amyloid-like fibers. Npj Biofilms and Microbiomes. 6: 15. PMID 32221298 DOI: 10.1038/s41522-020-0125-2   
2020 Eke CS, Jammeh E, Li X, Carroll C, Pearson S, Ifeachor E. Early Detection of Alzheimer's Disease with Blood Plasma Proteins using Support Vector Machines. Ieee Journal of Biomedical and Health Informatics. PMID 32340968 DOI: 10.1109/JBHI.2020.2984355   
2020 Gião T, Saavedra J, Cotrina E, Quintana J, Llop J, Arsequell G, Cardoso I. Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32197355 DOI: 10.3390/ijms21062075   
2020 Lim CH, Kaur P, Teo E, Lam VYM, Zhu F, Kibat C, Gruber J, Mathuru AS, Tolwinski NS. Application of optogenetic Amyloid-β distinguishes between metabolic and physical damage in neurodegeneration. Elife. 9. PMID 32228858 DOI: 10.7554/eLife.52589   
2020 Cho HJ, Sharma AK, Zhang Y, Gross ML, Mirica LM. A Multifunctional Chemical Agent as an Attenuator of Amyloid Burden and Neuroinflammation in Alzheimer's Disease. Acs Chemical Neuroscience. PMID 32310630 DOI: 10.1021/acschemneuro.0c00114   
2020 Amponsah AE, Feng B, Guo R, Zhang W, He J, Kong D, Dong T, Ma J, Cui H. Fragmentation of brain apolipoprotein E (ApoE) and its relevance in Alzheimer's disease. Reviews in the Neurosciences. PMID 32364519 DOI: 10.1515/revneuro-2019-0115   
2020 Patil GV, Joshi RS, Kazi RS, Kulsange SE, Kulkarni MJ. A possible role of glycation in the regulation of amyloid β precursor protein processing leading to amyloid β accumulation. Medical Hypotheses. 142: 109799. PMID 32388478 DOI: 10.1016/j.mehy.2020.109799   
2020 Deng L, Haynes PA, Wu Y, Amirkhani A, Kamath KS, Wu JX, Pushpitha K, Gupta V, Graham S, Gupta VK, Mirzaei M. Amyloid-beta peptide neurotoxicity in human neuronal cells is associated with modulation of insulin-like growth factor transport, lysosomal machinery and extracellular matrix receptor interactions. Neural Regeneration Research. 15: 2131-2142. PMID 32394972 DOI: 10.4103/1673-5374.282261   
2020 Yang J, Wise L, Fukuchi KI. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in Immunology. 11: 724. PMID 32391019 DOI: 10.3389/fimmu.2020.00724   
2020 van Dam L, Dansen TB. Cross-talk between redox signalling and protein aggregation. Biochemical Society Transactions. 48: 379-397. PMID 32311028 DOI: 10.1042/BST20190054   
2020 Ahmad S, Milan MDC, Hansson O, Demirkan A, Agustin R, Sáez ME, Giagtzoglou N, Cabrera-Socorro A, Bakker MHM, Ramirez A, Hankemeier T, Stomrud E, Mattsson-Carlgren N, Scheltens P, van der Flier WM, et al. CDH6 and HAGH protein levels in plasma associate with Alzheimer's disease in APOE ε4 carriers. Scientific Reports. 10: 8233. PMID 32427856 DOI: 10.1038/s41598-020-65038-5   
2020 Uemura N, Uemura MT, Luk KC, Lee VM, Trojanowski JQ. Cell-to-Cell Transmission of Tau and α-Synuclein. Trends in Molecular Medicine. PMID 32371172 DOI: 10.1016/j.molmed.2020.03.012   
2020 Reus LM, Stringer S, Posthuma D, Teunissen CE, Scheltens P, Pijnenburg YAL, Visser PJ, Tijms BM, . Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid. Neurobiology of Aging. PMID 32307133 DOI: 10.1016/j.neurobiolaging.2020.03.012   
2020 Walsh DM, Selkoe DJ. Amyloid β-protein and beyond: the path forward in Alzheimer's disease. Current Opinion in Neurobiology. 61: 116-124. PMID 32197217 DOI: 10.1016/j.conb.2020.02.003   
2020 Xu G, Fromholt SE, Chakrabarty P, Zhu F, Liu X, Pace MC, Koh J, Golde TE, Levites Y, Lewis J, Borchelt DR. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathologica Communications. 8: 43. PMID 32252825 DOI: 10.1186/s40478-020-00911-y   
2020 van Gils JHM, van Dijk E, Peduzzo A, Hofmann A, Vettore N, Schützmann MP, Groth G, Mouhib H, Otzen DE, Buell AK, Abeln S. The hydrophobic effect characterises the thermodynamic signature of amyloid fibril growth. Plos Computational Biology. 16: e1007767. PMID 32365068 DOI: 10.1371/journal.pcbi.1007767   
2020 Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of Aging. 92: 82-91. PMID 32408056 DOI: 10.1016/j.neurobiolaging.2020.03.024   
2020 Malpas CB, Sharmin S, Kalincik T. The histopathological staging of tau, but not amyloid, corresponds to antemortem cognitive status, dementia stage, functional abilities, and neuropsychiatric symptoms. The International Journal of Neuroscience. 1-13. PMID 32303140 DOI: 10.1080/00207454.2020.1758087   
2020 Debasmita T, Alice M, Federica C, Alessandro R, Pamela G, Federica F, Lucia B, Diego A, Juárez-Hernández Leon J, Carlo M, Laura C, Mario S, Wilhelmus Micha MM, Benjamin D, Maria P, et al. Increased transcription of transglutaminase 1 mediates neuronal death in in vitro models of neuronal stress and Aβ1-42-mediated toxicity. Neurobiology of Disease. 104849. PMID 32222473 DOI: 10.1016/j.nbd.2020.104849   
2020 Weidling IW, Swerdlow RH. Mitochondria in Alzheimer's disease and their potential role in Alzheimer's proteostasis. Experimental Neurology. 330: 113321. PMID 32339611 DOI: 10.1016/j.expneurol.2020.113321   
2020 Kim BH, Choi YH, Yang JJ, Kim S, Nho K, Lee JM, . Identification of Novel Genes Associated with Cortical Thickness in Alzheimer's Disease: Systems Biology Approach to Neuroimaging Endophenotype. Journal of Alzheimer's Disease : Jad. PMID 32310165 DOI: 10.3233/JAD-191175   
2020 Lim KH, Joo JY. Predictive Potential of Circulating Ube2h mRNA as an E2 Ubiquitin-Conjugating Enzyme for Diagnosis or Treatment of Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32403399 DOI: 10.3390/ijms21093398   
2020 Li JP, Zhang X. Implications of Heparan Sulfate and Heparanase in Amyloid Diseases. Advances in Experimental Medicine and Biology. 1221: 631-645. PMID 32274729 DOI: 10.1007/978-3-030-34521-1_25   
2020 Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM. Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. International Immunopharmacology. 84: 106479. PMID 32353686 DOI: 10.1016/j.intimp.2020.106479   
2020 Kelliny S, Lam HY, Parikh A, Wang Y, Bobrovskaya L, Upton R, Zhou XF. Preclinical Study of the Pharmacokinetics of p75ECD-Fc, a Novel Human Recombinant Protein for Treatment of Alzheimer's Disease, in Sprague Dawley rats. Current Drug Metabolism. PMID 32357812 DOI: 10.2174/1389200221666200502015203   
2020 Dear AJ, Michaels TCT, Meisl G, Klenerman D, Wu S, Perrett S, Linse S, Dobson CM, Knowles TPJ. Kinetic diversity of amyloid oligomers. Proceedings of the National Academy of Sciences of the United States of America. PMID 32414930 DOI: 10.1073/pnas.1922267117   
2020 Tsatsanis A, Wong BX, Gunn AP, Ayton S, Bush AI, Devos D, Duce JA. Amyloidogenic processing of Alzheimer's disease β-amyloid precursor protein induces cellular iron retention. Molecular Psychiatry. PMID 32444869 DOI: 10.1038/s41380-020-0762-0   
2020 Kumar D, Ambasta RK, Kumar P. Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies. Ageing Research Reviews. 101078. PMID 32407951 DOI: 10.1016/j.arr.2020.101078   
2020 Llorach-Pares L, Rodriguez-Urgelles E, Nonell-Canals A, Alberch J, Avila C, Sanchez-Martinez M, Giralt A. Meridianins and Lignarenone B as Potential GSK3β Inhibitors and Inductors of Structural Neuronal Plasticity. Biomolecules. 10. PMID 32326204 DOI: 10.3390/biom10040639