Samuel E. Gandy, MD PhD - Publications

Neurology and Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY, United States 

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Year Citation  Score
2017 Pullman MY, Dickstein DL, DeKosky ST, Gandy S. Antemortem biomarker support for a diagnosis of clinically probable chronic traumatic encephalopathy. Molecular Psychiatry. 22: 638-639. PMID 28070125 DOI: 10.1038/mp.2016.236  0.32
2017 Gandy S, Dickstein D, Pullman M, Short J, Kostakoglu L, Knesaurek K, Jordan B, Gordon W, Dams-O'Connor K, Tang C, Wong E, DeKosky S, Stone J, Farmer G, Peskind ER, et al. [P4-232]: TAU IMAGING WITH [18 F]T807/AV-1451 IN ATHLETES WITH POST-CONCUSSIVE COMPLAINT AND CONTROLS Alzheimer's & Dementia. 13: P1361-P1361. DOI: 10.1016/j.jalz.2017.06.2100  0.32
2016 Dickstein DL, Pullman MY, Fernandez C, Short JA, Kostakoglu L, Knesaurek K, Soleimani L, Jordan BD, Gordon WA, Dams-O'Connor K, Delman BN, Wong E, Tang CY, DeKosky ST, Stone JR, ... ... Gandy S, et al. Cerebral [(18) F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy. Translational Psychiatry. 6: e900. PMID 27676441 DOI: 10.1038/tp.2016.175  0.36
2016 Bates KA, Sohrabi HR, Rainey-Smith SR, Weinborn M, Bucks Rs RS, Rodrigues M, Beilby J, Howard M, Taddei K, Martins G, A AP, Shah T, Dhaliwal SS, Foster JK, Martins IJ, ... ... Gandy S, et al. Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. The International Journal of Neuroscience. 1-31. PMID 27113638 DOI: 10.1080/00207454.2016.1182527  0.84
2016 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APPE693Q and fibrillogenic APPKM670/671NL/PSEN1?exon9 mouse models identifies shared features with human Alzheimer’s brain molecular pathology Molecular Psychiatry. DOI: 10.1038/mp.2015.215  0.84
2015 Hunsberger JG, Rao M, Kurtzberg J, Bulte JW, Atala A, LaFerla FM, Greely HT, Sawa A, Gandy S, Schneider LS, Doraiswamy PM. Accelerating stem cell trials for Alzheimer's disease. The Lancet. Neurology. PMID 26704439 DOI: 10.1016/S1474-4422(15)00332-4  0.84
2015 Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Scientific Reports. 5: 17042. PMID 26608390 DOI: 10.1038/srep17042  0.84
2015 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26552589 DOI: 10.1038/mp.2015.167  0.84
2015 Gandy S, Sano M. Alzheimer disease: Solanezumab-prospects for meaningful interventions in AD? Nature Reviews. Neurology. 11: 669-70. PMID 26526537 DOI: 10.1038/nrneurol.2015.218  0.84
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/pnas.1510011112  0.84
2015 Carman AJ, Ferguson R, Cantu R, Comstock RD, Dacks PA, DeKosky ST, Gandy S, Gilbert J, Gilliland C, Gioia G, Giza C, Greicius M, Hainline B, Hayes RL, Hendrix J, et al. Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions. Nature Reviews. Neurology. 11: 230-44. PMID 25776822 DOI: 10.1038/nrneurol.2015.30  0.84
2015 Zetterberg H, Gandy S. Repetitive concussions--How dangerous are they? Molecular and Cellular Neurosciences. 66: 73-4. PMID 25655012 DOI: 10.1016/j.mcn.2015.02.004  0.84
2015 Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. Molecular Psychiatry. 20: 109-17. PMID 25349165 DOI: 10.1038/mp.2014.135  0.84
2014 Gandy S, DeKosky ST. [18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy. F1000research. 3: 229. PMID 25469232 DOI: 10.12688/f1000research.5372.1  0.84
2014 Gandy S, Ikonomovic MD, Mitsis E, Elder G, Ahlers ST, Barth J, Stone JR, DeKosky ST. Chronic traumatic encephalopathy: clinical-biomarker correlations and current concepts in pathogenesis. Molecular Neurodegeneration. 9: 37. PMID 25231386 DOI: 10.1186/1750-1326-9-37  0.84
2014 Mitsis EM, Riggio S, Kostakoglu L, Dickstein DL, Machac J, Delman B, Goldstein M, Jennings D, D'Antonio E, Martin J, Naidich TP, Aloysi A, Fernandez C, Seibyl J, DeKosky ST, ... ... Gandy S, et al. Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury. Translational Psychiatry. 4: e441. PMID 25226550 DOI: 10.1038/tp.2014.91  0.84
2014 Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Molecular Psychiatry. 19: 1235-42. PMID 25113378 DOI: 10.1038/mp.2014.87  0.84
2014 DeKosky ST, Gandy S. Alzheimer disease risk factors--reply. Jama Neurology. 71: 1051-2. PMID 25111207 DOI: 10.1001/jamaneurol.2014.636  0.84
2014 Knight EM, Gandy S. Immunomodulation and AD--down but not out. Journal of Clinical Immunology. 34: S70-3. PMID 24781637 DOI: 10.1007/s10875-014-0039-y  0.84
2014 Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS. Alzheimer's disease research and development: a call for a new research roadmap. Annals of the New York Academy of Sciences. 1313: 1-16. PMID 24754377 DOI: 10.1111/nyas.12424  0.84
2014 Mitsis EM, Bender HA, Kostakoglu L, Machac J, Martin J, Woehr JL, Sewell MC, Aloysi A, Goldstein MA, Li C, Sano M, Gandy S. A consecutive case series experience with [18 F] florbetapir PET imaging in an urban dementia center: impact on quality of life, decision making, and disposition. Molecular Neurodegeneration. 9: 10. PMID 24484858 DOI: 10.1186/1750-1326-9-10  0.84
2014 Dekosky ST, Gandy S. Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns? Jama Neurology. 71: 273-5. PMID 24473699 DOI: 10.1001/jamaneurol.2013.6031  0.84
2014 Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, et al. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. Plos One. 9: e84547. PMID 24416243 DOI: 10.1371/journal.pone.0084547  0.84
2014 Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model. The Journal of Comparative Neurology. 522: 2319-35. PMID 24415002 DOI: 10.1002/cne.23536  0.84
2014 Gandy S. Alzheimer's disease: new data highlight nonneuronal cell types and the necessity for presymptomatic prevention strategies. Biological Psychiatry. 75: 553-7. PMID 24373429 DOI: 10.1016/j.biopsych.2013.11.019  0.84
2013 Bharadwaj PR, Bates KA, Porter T, Teimouri E, Perry G, Steele JW, Gandy S, Groth D, Martins RN, Verdile G. Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases. Translational Psychiatry. 3: e332. PMID 24301650 DOI: 10.1038/tp.2013.97  0.84
2013 Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/jbc.M113.504365  0.84
2013 Gandy S, Heppner FL. Microglia as dynamic and essential components of the amyloid hypothesis. Neuron. 78: 575-7. PMID 23719156 DOI: 10.1016/j.neuron.2013.05.007  0.84
2013 Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7099-107. PMID 23595767 DOI: 10.1523/JNEUROSCI.5270-12.2013  0.6
2013 DeKosky ST, Blennow K, Ikonomovic MD, Gandy S. Acute and chronic traumatic encephalopathies: pathogenesis and biomarkers. Nature Reviews. Neurology. 9: 192-200. PMID 23558985 DOI: 10.1038/nrneurol.2013.36  0.84
2013 Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biological Psychiatry. 73: 393-5. PMID 23399469 DOI: 10.1016/j.biopsych.2013.01.013  0.84
2013 Steele JW, Gandy S. Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy. 9: 617-8. PMID 23380933 DOI: 10.4161/auto.23487  0.84
2013 Gandy S, DeKosky ST. Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress. Annual Review of Medicine. 64: 367-83. PMID 23327526 DOI: 10.1146/annurev-med-092611-084441  0.84
2013 Gandy S, DeKosky ST. 2012: the year in dementia. The Lancet. Neurology. 12: 4-6. PMID 23237888 DOI: 10.1016/S1474-4422(12)70284-3  0.84
2013 Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Gandy S, et al. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 18: 882-8. PMID 22869031 DOI: 10.1038/mp.2012.115  0.84
2013 Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Gandy S, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 18: 889-97. PMID 22850627 DOI: 10.1038/mp.2012.106  0.84
2012 Kim SH, Knight EM, Saunders EL, Cuevas AK, Popovech M, Chen LC, Gandy S. Rapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution. F1000research. 1: 70. PMID 24358824 DOI: 10.12688/f1000research.1-70.v1  0.84
2012 De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Acute blast injury reduces brain abeta in two rodent species. Frontiers in Neurology. 3: 177. PMID 23267342 DOI: 10.3389/fneur.2012.00177  0.84
2012 Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease. Molecular Neurodegeneration. 7: 58. PMID 23173713 DOI: 10.1186/1750-1326-7-58  0.84
2012 Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14080-6. PMID 23055476 DOI: 10.1523/JNEUROSCI.3359-12.2012  0.84
2012 Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D. Dynamin 1 regulates amyloid generation through modulation of BACE-1. Plos One. 7: e45033. PMID 23024787 DOI: 10.1371/journal.pone.0045033  0.84
2012 Gandy S. Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease. The New England Journal of Medicine. 367: 864-6. PMID 22931321 DOI: 10.1056/NEJMe1207995  0.84
2012 Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, et al. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's Disease : Jad. 32: 949-67. PMID 22903131 DOI: 10.3233/JAD-2012-120178  0.84
2012 Sohrabi HR, Bates KA, Weinborn MG, Johnston AN, Bahramian A, Taddei K, Laws SM, Rodrigues M, Morici M, Howard M, Martins G, Mackay-Sim A, Gandy SE, Martins RN. Olfactory discrimination predicts cognitive decline among community-dwelling older adults. Translational Psychiatry. 2: e118. PMID 22832962 DOI: 10.1038/tp.2012.43  0.84
2012 Gandy S, Dekosky ST. APOE ε4 status and traumatic brain injury on the gridiron or the battlefield. Science Translational Medicine. 4: 134ed4. PMID 22593171 DOI: 10.1126/scitranslmed.3004274  0.84
2012 Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular Neurodegeneration. 7: 16. PMID 22534039 DOI: 10.1186/1750-1326-7-16  0.84
2012 Caesar I, Gandy S. Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease. Bmc Medicine. 10: 36. PMID 22502767 DOI: 10.1186/1741-7015-10-36  0.84
2012 Keilani S, Lun Y, Stevens AC, Williams HN, Sjoberg ER, Khanna R, Valenzano KJ, Checler F, Buxbaum JD, Yanagisawa K, Lockhart DJ, Wustman BA, Gandy S. Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5223-36. PMID 22496568 DOI: 10.1523/JNEUROSCI.4860-11.2012  0.84
2012 Gandy S. The editorialist replies New England Journal of Medicine. 367: 2051-2052. DOI: 10.1056/NEJMc1211767  0.84
2011 Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T. Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Molecular Neurodegeneration. 6: 76. PMID 22067061 DOI: 10.1186/1750-1326-6-76  0.84
2011 Ehrlich ME, Gandy S. Chromatin plasticity and the pathogenesis of Huntington disease. Proceedings of the National Academy of Sciences of the United States of America. 108: 16867-8. PMID 21969556 DOI: 10.1073/pnas.1113321108  0.84
2011 Gandy S. Perspective: prevention is better than cure. Nature. 475: S15. PMID 21760576 DOI: 10.1038/475S15a  0.84
2011 Costanza A, Weber K, Gandy S, Bouras C, Hof PR, Giannakopoulos P, Canuto A. Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathology and Applied Neurobiology. 37: 570-84. PMID 21696410 DOI: 10.1111/j.1365-2990.2011.01186.x  0.84
2011 Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Gandy S, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/ana.22343  0.84
2011 Sohrabi HR, Weinborn M, Badcock J, Bates KA, Clarnette R, Trivedi D, Verdile G, Sutton T, Lenzo NP, Gandy SE, Martins RN. New lexicon and criteria for the diagnosis of Alzheimer's disease. The Lancet. Neurology. 10: 299-300; author repl. PMID 21435594 DOI: 10.1016/S1474-4422(11)70056-4  0.84
2011 Steele JW, Gandy S. Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation? Annals of Neurology. 69: 221-5. PMID 21387363 DOI: 10.1002/ana.22359  0.84
2011 Gandy S, Wustman B. New pathway links γ-secretase to inflammation and memory while sparing notch. Annals of Neurology. 69: 5-7. PMID 21280069 DOI: 10.1002/ana.22310  0.84
2011 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-β metabolism: Evidence for involvement of SorL1 and the retromer complex (Journal of Neuroscience (2010) (13110-13115)) Journal of Neuroscience. 31.  0.84
2010 Lane RF, Gatson JW, Small SA, Ehrlich ME, Gandy S. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Molecular Neurodegeneration. 5: 62. PMID 21192821 DOI: 10.1186/1750-1326-5-62  0.84
2010 Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Molecular Neurodegeneration. 5: 40. PMID 20937087 DOI: 10.1186/1750-1326-5-40  0.84
2010 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13110-5. PMID 20881129 DOI: 10.1523/JNEUROSCI.3872-10.2010  0.6
2010 DeKosky ST, Ikonomovic MD, Gandy S. Traumatic brain injury--football, warfare, and long-term effects. The New England Journal of Medicine. 363: 1293-6. PMID 20879875 DOI: 10.1056/NEJMp1007051  0.84
2010 Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/ana.22052  0.84
2010 Sharman MJ, Morici M, Hone E, Berger T, Taddei K, Martins IJ, Lim WL, Singh S, Wenk MR, Ghiso J, Buxbaum JD, Gandy S, Martins RN. APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. Journal of Alzheimer's Disease : Jad. 21: 403-9. PMID 20555142 DOI: 10.3233/JAD-2010-100141  0.84
2010 Jenner AM, Lim WL, Ng MP, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience. 169: 109-15. PMID 20416362 DOI: 10.1016/j.neuroscience.2010.04.026  0.84
2010 Kim SH, Fraser PE, Westaway D, St George-Hyslop PH, Ehrlich ME, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3870-5. PMID 20237257 DOI: 10.1523/JNEUROSCI.4717-09.2010  0.84
2010 Kajiwara Y, Franciosi S, Takahashi N, Krug L, Schmeidler J, Taddei K, Haroutunian V, Fried U, Ehrlich M, Martins RN, Gandy S, Buxbaum JD. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration. 5: 1. PMID 20205790 DOI: 10.1186/1750-1326-5-1  0.84
2010 Gandy S. Testing the amyloid hypothesis of Alzheimer's disease in vivo. The Lancet. Neurology. 9: 333-5. PMID 20189880 DOI: 10.1016/S1474-4422(10)70055-7  0.84
2010 Sharman MJ, Shui G, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum JD, Gandy S, Wenk MR, Martins RN. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's Disease : Jad. 20: 105-11. PMID 20164599 DOI: 10.3233/JAD-2010-1348  0.84
2010 Lublin AL, Gandy S. Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. The Mount Sinai Journal of Medicine, New York. 77: 43-9. PMID 20101723 DOI: 10.1002/msj.20160  0.84
2010 Dickstein DL, Walsh J, Brautigam H, Stockton SD, Gandy S, Hof PR. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. The Mount Sinai Journal of Medicine, New York. 77: 82-102. PMID 20101718 DOI: 10.1002/msj.20155  0.84
2010 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia Neuroforum. 16: 164-167.  0.84
2009 Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51  0.84
2009 Kaufer D, Gandy S. APOE {epsilon}4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics. Neurology. 73: 2052-3. PMID 19923549 DOI: 10.1212/WNL.0b013e3181c6784a  0.84
2009 Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, ... ... Gandy S, et al. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. The Journal of Biological Chemistry. 284: 36024-33. PMID 19864413 DOI: 10.1074/jbc.M109.057497  0.84
2009 Franciosi S, Gama Sosa MA, English DF, Oler E, Oung T, Janssen WG, De Gasperi R, Schmeidler J, Dickstein DL, Schmitz C, Gandy S, Hof PR, Buxbaum JD, Elder GA. Novel cerebrovascular pathology in mice fed a high cholesterol diet. Molecular Neurodegeneration. 4: 42. PMID 19852847 DOI: 10.1186/1750-1326-4-42  0.84
2009 Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration. 4: 40. PMID 19845940 DOI: 10.1186/1750-1326-4-40  0.84
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1038/nn.2432  0.84
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/cb900112v  0.84
2009 Sohrabi HR, Bates KA, Rodrigues M, Taddei K, Laws SM, Lautenschlager NT, Dhaliwal SS, Johnston AN, Mackay-Sim A, Gandy S, Foster JK, Martins RN. Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's Disease : Jad. 17: 135-42. PMID 19494438 DOI: 10.3233/JAD-2009-1020  0.84
2009 Gandy S. An interview with Samuel Gandy, MD, PhD: Alzheimer's disease by Norman Sussman. Cns Spectrums. 14: 248-51. PMID 19489174  0.84
2009 Bates KA, Sohrabi HR, Rodrigues M, Beilby J, Dhaliwal SS, Taddei K, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager NT, ... ... Gandy SE, et al. Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers. Journal of Alzheimer's Disease : Jad. 17: 305-18. PMID 19363264 DOI: 10.3233/JAD-2009-1050  0.84
2009 Boyd JL, Casson I, DeKosky S, Feuer H, Gandy S, Khachaturian Z, Kinoshita J, Marchesi V, McKee A, Nowinski C, Perl D, Purohit D, Relkin N, Smith MA, Strobel G, et al. Alzheimer research forum live discussion: Sports concussions, dementia, and ApoE genotyping: What can scientists tell the public? What's up for research? Journal of Alzheimer's Disease. 16: 657-666. PMID 19276560 DOI: 10.3233/JAD-2009-1014  0.84
2009 Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Nairn AC, Nakaya T, Yamamoto T, Suzuki T. Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. Journal of Neurochemistry. 109: 465-75. PMID 19222704 DOI: 10.1111/j.1471-4159.2009.05988.x  0.84
2009 Amadio M, Pascale A, Wang J, Ho L, Quattrone A, Gandy S, Haroutunian V, Racchi M, Pasinetti GM. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing. Journal of Alzheimer's Disease : Jad. 16: 409-19. PMID 19221430 DOI: 10.3233/JAD-2009-0967  0.84
2009 da Cruz e Silva OA, Rebelo S, Vieira SI, Gandy S, da Cruz e Silva EF, Greengard P. Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. Journal of Neurochemistry. 108: 319-30. PMID 19012746 DOI: 10.1111/j.1471-4159.2008.05770.x  0.84
2009 Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging. 30: 1587-600. PMID 18406011 DOI: 10.1016/j.neurobiolaging.2007.12.013  0.84
2008 Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S, Pasinetti GM. Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration. Annals of the New York Academy of Sciences. 1147: 335-47. PMID 19076455 DOI: 10.1196/annals.1427.024  0.84
2008 Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. The Journal of Biological Chemistry. 283: 35763-71. PMID 18845544 DOI: 10.1074/jbc.M801353200  0.84
2008 Beeri MS, Schmeidler J, Silverman JM, Gandy S, Wysocki M, Hannigan CM, Purohit DP, Lesser G, Grossman HT, Haroutunian V. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology. 71: 750-7. PMID 18765651 DOI: 10.1212/01.wnl.0000324925.95210.6d  0.84
2008 Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, et al. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation. 5: 36. PMID 18715507 DOI: 10.1186/1742-2094-5-36  0.84
2007 Ikin AF, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashiyama S, Mustelin T, Burgoyne RD, Gandy S. Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding. Molecular Neurodegeneration. 2: 23. PMID 18067682 DOI: 10.1186/1750-1326-2-23  0.84
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/j.1471-4159.2007.04587.x  0.84
2007 Verdile G, Gandy SE, Martins RN. The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochemical Research. 32: 609-23. PMID 16944319 DOI: 10.1007/s11064-006-9131-x  0.84
2006 Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. Plos One. 1: e51. PMID 17183681 DOI: 10.1371/journal.pone.0000051  0.84
2006 Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). Journal of Alzheimer's Disease : Jad. 10: 417-22. PMID 17183154  0.84
2006 Greenberg SM, Rosand J, Schneider AT, Creed Pettigrew L, Gandy SE, Rovner B, Fitzsimmons BF, Smith EE, Edip Gurol M, Schwab K, Laurin J, Garceau D. A phase 2 study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Disease and Associated Disorders. 20: 269-74. PMID 17132972 DOI: 10.1097/01.wad.0000213845.28624.f4  0.84
2006 Gandy S, Doeven MK, Poolman B. Alzheimer disease: presenilin springs a leak. Nature Medicine. 12: 1121-3. PMID 17024202 DOI: 10.1038/nm1006-1121  0.84
2006 Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron. 52: 15-31. PMID 17015224 DOI: 10.1016/j.neuron.2006.09.001  0.84
2006 Strobel G, Smith M, Gandy S, Breitner J, Wise P, Toran-Allerand D, Atwood C, Gregory C, Li R, McAsey M, Brinton R, Barbee J, Struble R, Zandi P, Zhao L, et al. Alzheimer research forum live discussion: Not dead yet: Estrogen deserves another chance Journal of Alzheimer's Disease. 10: 121-130. PMID 16988489 DOI: 10.3233/jad-2006-10116  0.84
2006 Martins IJ, Hone E, Foster JK, Sünram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry. 11: 721-36. PMID 16786033 DOI: 10.1038/  0.84
2006 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. The Journal of Biological Chemistry. 281: 21745-54. PMID 16751189 DOI: 10.1074/jbc.M602909200  0.84
2006 Carter TL, Pedrini S, Ghiso J, Ehrlich ME, Gandy S. Brain neprilysin activity and susceptibility to transgene-induced Alzheimer amyloidosis. Neuroscience Letters. 392: 235-9. PMID 16233955 DOI: 10.1016/j.neulet.2005.09.022  0.84
2005 Balakrishnan K, Verdile G, Mehta PD, Beilby J, Nolan D, Galvão DA, Newton R, Gandy SE, Martins RN. Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's Disease : Jad. 8: 269-82. PMID 16340084 DOI: 10.3233/JAD-2005-8305  0.84
2005 Lautenschlager NT, Wu JS, Laws SM, Almeida OP, Clarnette RM, Joesbury K, Wagenpfeil S, Martins G, Paton A, Gandy SE, Förstl H, Martins RN. Neurological soft signs are associated with APOE genotype, age and cognitive performance. Journal of Alzheimer's Disease : Jad. 7: 325-30. PMID 16131735 DOI: 10.3233/JAD-2005-7409  0.84
2005 Hone E, Martins IJ, Jeoung M, Ji TH, Gandy SE, Martins RN. Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. Journal of Alzheimer's Disease : Jad. 7: 303-14. PMID 16131732 DOI: 10.3233/JAD-2005-7406  0.84
2004 Verdile G, Fuller S, Atwood CS, Laws SM, Gandy SE, Martins RN. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 50: 397-409. PMID 15304237 DOI: 10.1016/j.phrs.2003.12.028  0.84
2004 Burkhardt MS, Foster JK, Laws SM, Baker LD, Craft S, Gandy SE, Stuckey BG, Clarnette R, Nolan D, Hewson-Bower B, Martins RN. Oestrogen replacement therapy may improve memory functioning in the absence of APOE epsilon4. Journal of Alzheimer's Disease : Jad. 6: 221-8. PMID 15201477 DOI: 10.3233/JAD-2004-6302  0.84
2004 Laudon H, Karlström H, Mathews PM, Farmery MR, Gandy SE, Lundkvist J, Lendahl U, Näslund J. Functional domains in presenilin 1: the Tyr-288 residue controls gamma-secretase activity and endoproteolysis. The Journal of Biological Chemistry. 279: 23925-32. PMID 15051718 DOI: 10.1074/jbc.M401277200  0.84
2004 Laudon H, Mathews PM, Karlström H, Bergman A, Farmery MR, Nixon RA, Winblad B, Gandy SE, Lendahl U, Lundkvist J, Näslund J. Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein. Journal of Neurochemistry. 89: 44-53. PMID 15030388 DOI: 10.1046/j.1471-4159.2003.02298.x  0.84
2003 Dean B, Laws SM, Hone E, Taddei K, Scarr E, Thomas EA, Harper C, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia. Biological Psychiatry. 54: 616-22. PMID 13129656 DOI: 10.1016/S0006-3223(03)00075-1  0.84
2003 Thomas EA, Laws SM, Sutcliffe JG, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological Psychiatry. 54: 136-41. PMID 12873803 DOI: 10.1016/S0006-3223(02)01976-5  0.84
2003 Kwok JB, Halliday GM, Brooks WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vickers J, Wang R, Naslund J, Takashima A, Gandy SE, Schofield PR. Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. The Journal of Biological Chemistry. 278: 6748-54. PMID 12493737 DOI: 10.1074/jbc.M211827200  0.84
2002 Laws SM, Hone E, Taddei K, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E. Molecular Psychiatry. 7: 886-90. PMID 12232782 DOI: 10.1038/  0.84
2002 Taddei K, Fisher C, Laws SM, Martins G, Paton A, Clarnette RM, Chung C, Brooks WS, Hallmayer J, Miklossy J, Relkin N, St George-Hyslop PH, Gandy SE, Martins RN. Association between presenilin-1 Glu318Gly mutation and familial Alzheimer's disease in the Australian population. Molecular Psychiatry. 7: 776-81. PMID 12192622 DOI: 10.1038/  0.84
2002 Laws SM, Clarnette RM, Taddei K, Martins G, Paton A, Hallmayer J, Almeida OP, Groth DM, Gandy SE, Förstl H, Martins RN. APOE-epsilon4 and APOE -491A polymorphisms in individuals with subjective memory loss. Molecular Psychiatry. 7: 768-75. PMID 12192621 DOI: 10.1038/  0.84
2002 Hedley R, Hallmayer J, Groth DM, Brooks WS, Gandy SE, Martins RN. Association of interleukin-1 polymorphisms with Alzheimer's disease in Australia. Annals of Neurology. 51: 795-7. PMID 12112093 DOI: 10.1002/ana.10196  0.84
2002 Yang DS, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt SD, Ramabhadran TV, Nixon RA, Mathews PM, Gandy SE, Mount HT, St George-Hyslop P, et al. Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. The Journal of Biological Chemistry. 277: 28135-42. PMID 12032140 DOI: 10.1074/jbc.M110871200  0.84
2000 Petanceska SS, Nagy V, Frail D, Gandy S. Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain Experimental Gerontology. 35: 1317-1325. PMID 11113610 DOI: 10.1016/S0531-5565(00)00157-1  0.84
2000 Boyt AA, Taddei TK, Hallmayer J, Helmerhorst E, Gandy SE, Craft S, Martins RN. The effect of insulin and glucose on the plasma concentration of Alzheimer's amyloid precursor protein. Neuroscience. 95: 727-34. PMID 10670439 DOI: 10.1016/S0306-4522(99)00458-3  0.84
1999 Yang DS, Small DH, Seydel U, Smith JD, Hallmayer J, Gandy SE, Martins RN. Apolipoprotein E promotes the binding and uptake of beta-amyloid into Chinese hamster ovary cells in an isoform-specific manner. Neuroscience. 90: 1217-26. PMID 10338292 DOI: 10.1016/S0306-4522(98)00561-2  0.84
1999 Laws SM, Taddei K, Martins G, Paton A, Fisher C, Clarnette R, Hallmayer J, Brooks WS, Gandy SE, Martins RN. The -491AA polymorphism in the APOE gene is associated with increased plasma apoE levels in Alzheimer's disease. Neuroreport. 10: 879-82. PMID 10208564 DOI: 10.1097/00001756-199903170-00038  0.84
1999 Boyt AA, Taddei K, Hallmayer J, Mamo J, Heimerhorst E, Gandy SE, Martins RN. Relationship between lipid metabolism and plasma concentration of amyloid precursor protein and apolipoprotein E Alzheimer's Reports. 2: 339-346.  0.84
1999 Laws SM, Taddei K, Fisher C, Small D, Clarnette R, Hallmayer J, Brooks WS, Kwok JBJ, Schofield PR, Gandy SE, Martins RN. Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease Alzheimer's Reports. 2: 219-223.  0.84
1998 Taddei K, Yang D, Fisher C, Clarnette R, Hallmayer J, Barnetson R, Maller R, Brooks WS, Whyte S, Nicholson GA, Masters CL, Broe GA, Gandy SE, Martins RN. No association of presenilin-1 intronic polymorphism and Alzheimer's disease in Australia. Neuroscience Letters. 246: 178-80. PMID 9792621 DOI: 10.1016/S0304-3940(98)00248-1  0.84
1998 Calingasan NY, Park LC, Gandy SE, Gibson GE. Disturbances of the blood-brain barrier without expression of amyloid precursor protein- containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs. Developmental Neuroscience. 20: 454-61. PMID 9778584 DOI: 10.1159/000017343  0.84
1998 Calingasan NY, Park LC, Calo LL, Trifiletti RR, Gandy SE, Gibson GE. Induction of nitric oxide synthase and microglial responses precede selective cell death induced by chronic impairment of oxidative metabolism. The American Journal of Pathology. 153: 599-610. PMID 9708819 DOI: 10.1016/S0002-9440(10)65602-7  0.84
1998 Fraser PE, Levesque G, Yu G, Mills LR, Thirlwell J, Frantseva M, Gandy SE, Seeger M, Carlen PL, St George-Hyslop P. Presenilin 1 is actively degraded by the 26S proteasome. Neurobiology of Aging. 19: S19-21. PMID 9562462 DOI: 10.1016/S0197-4580(98)00029-3  0.84
1997 Walker LC, Parker CA, Lipinski WJ, Callahan MJ, Carroll RT, Gandy SE, Smith JD, Jucker M, Bisgaier CL. Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. The American Journal of Pathology. 151: 1371-7. PMID 9358763  0.84
1997 Gibson GE, Calingasan NY, Baker H, Gandy S, Sheu KFR. Importance of vascular changes in selective neurodegeneration with thiamine deficiency Annals of the New York Academy of Sciences. 826: 516-519. PMID 9329737 DOI: 10.1111/j.1749-6632.1997.tb48517.x  0.84
1997 Calingasan NY, Gandy SE, Gibson GE. Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Neuroreport. 8: 2631-4. PMID 9261840  0.84
1997 Kwok JB, Taddei K, Hallupp M, Fisher C, Brooks WS, Broe GA, Hardy J, Fulham MJ, Nicholson GA, Stell R, St George Hyslop PH, Fraser PE, Kakulas B, Clarnette R, Relkin N, ... Gandy SE, et al. Two novel (M233T and R278T) presenilin-1 mutations in early-onset Alzheimer's disease pedigrees and preliminary evidence for association of presenilin-1 mutations with a novel phenotype. Neuroreport. 8: 1537-42. PMID 9172170  0.84
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/bi962618k  0.84
1997 Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T. The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. Molecular Medicine (Cambridge, Mass.). 3: 111-23. PMID 9085254  0.84
1997 Taddei K, Clarnette R, Gandy SE, Martins RN. Increased plasma apolipoprotein E (apoE) levels in Alzheimer's disease. Neuroscience Letters. 223: 29-32. PMID 9058415 DOI: 10.1016/S0304-3940(97)13394-8  0.84
1997 Yang DS, Smith JD, Zhou Z, Gandy SE, Martins RN. Characterization of the binding of amyloid-beta peptide to cell culture-derived native apolipoprotein E2, E3, and E4 isoforms and to isoforms from human plasma. Journal of Neurochemistry. 68: 721-5. PMID 9003062 DOI: 10.1046/j.1471-4159.1997.68020721.x  0.84
1997 Tjernberg LO, Näslund J, Thyberg J, Gandy SE, Terenius L, Nordstedt C. Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis. The Journal of Biological Chemistry. 272: 1870-5. PMID 8999874 DOI: 10.1074/jbc.272.3.1870  0.84
1996 Van Setten GB, Nilsson L, Hahne S, Johnston JA, Kvanta A, Gandy SE, Näslund J, Nordstedt C. Beta-amyloid protein protein precursor expression in lacrimal glands and tear fluid. Investigative Ophthalmology & Visual Science. 37: 2585-93. PMID 8977472  0.84
1996 Wang R, Sweeney D, Gandy SE, Sisodia SS. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. The Journal of Biological Chemistry. 271: 31894-902. PMID 8943233 DOI: 10.1074/jbc.271.50.31894  0.84
1996 Doan A, Thinakaran G, Borchelt DR, Slunt HH, Ratovitsky T, Podlisny M, Selkoe DJ, Seeger M, Gandy SE, Price DL, Sisodia SS. Protein topology of presenilin 1. Neuron. 17: 1023-30. PMID 8938133 DOI: 10.1016/S0896-6273(00)80232-9  0.84
1996 Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5  0.84
1996 Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7513-25. PMID 8922407  0.84
1996 Relkin NR, Edgar MA, Gouras GK, Gandy SE, Goldsmith HS. Decreased senile plaque density in Alzheimer neocortex adjacent to an omental transposition. Neurological Research. 18: 291-4; discussion 29. PMID 8875444  0.84
1996 Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408  0.84
1996 Thinakaran G, Borchelt DR, Lee MK, Slunt HH, Spitzer L, Kim G, Ratovitsky T, Davenport F, Nordstedt C, Seeger M, Hardy J, Levey AI, Gandy SE, Jenkins NA, Copeland NG, et al. Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo. Neuron. 17: 181-90. PMID 8755489 DOI: 10.1016/S0896-6273(00)80291-3  0.84
1995 Näslund J, Thyberg J, Tjernberg LO, Wernstedt C, Karlström AR, Bogdanovic N, Gandy SE, Lannfelt L, Terenius L, Nordstedt C. Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron. 15: 219-28. PMID 7619525 DOI: 10.1016/0896-6273(95)90079-9  0.84
1995 Calingasan NY, Gandy SE, Baker H, Sheu KF, Kim KS, Wisniewski HM, Gibson GE. Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain Research. 677: 50-60. PMID 7606469 DOI: 10.1016/0006-8993(95)00136-E  0.84
1995 Price DL, Sisodia SS, Gandy SE. Amyloid beta amyloidosis in Alzheimer's disease. Current Opinion in Neurology. 8: 268-74. PMID 7582041  0.84
1995 Martins RN, Clarnette R, Fisher C, Broe GA, Brooks WS, Montgomery P, Gandy SE. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport. 6: 1513-6. PMID 7579137  0.84
1994 Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, Greengard P, De Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3122-38. PMID 8182461  0.84
1994 Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. The Journal of Biological Chemistry. 269: 13065-8. PMID 8175728  0.84
1994 Nordstedt C, Näslund J, Thyberg J, Messamore E, Gandy SE, Terenius L. Human neutrophil phagocytic granules contain a truncated soluble form of the Alzheimer beta/A4 amyloid precursor protein (APP). The Journal of Biological Chemistry. 269: 9805-10. PMID 8144573  0.84
1994 Näslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proceedings of the National Academy of Sciences of the United States of America. 91: 8378-82. PMID 8078890 DOI: 10.1073/PNAS.91.18.8378  0.84
1994 Zhang H, Komano H, Fuller RS, Gandy SE, Frail DE. Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity. The Journal of Biological Chemistry. 269: 27799-802. PMID 7961704  0.84
1994 Gandy S, Greengard P. Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease International Review of Neurobiology. 36: 29-50. PMID 7822119 DOI: 10.1016/S0074-7742(08)60302-5  0.84
1994 Gandy S, Greengard P. Regulated cleavage of the Alzheimer amyloid precursor protein: Molecular and cellular basis Biochimie. 76: 300-303. PMID 7819339 DOI: 10.1016/0300-9084(94)90162-7  0.84
1994 Ouimet CC, Baerwald KD, Gandy SE, Greengard P. Immunocytochemical localization of amyloid precursor protein in rat brain. The Journal of Comparative Neurology. 348: 244-60. PMID 7814690 DOI: 10.1002/cne.903480207  0.84
1993 Ramabhadran TV, Gandy SE, Ghiso J, Czernik AJ, Ferris D, Bhasin R, Goldgaber D, Frangione B, Greengard P. Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart. The Journal of Biological Chemistry. 268: 2009-12. PMID 8420974  0.84
1993 Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P. Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. The Journal of Biological Chemistry. 268: 608-12. PMID 8416966  0.84
1993 Gandy SE, Caporaso GL, Buxbaum JD, de Cruz Silva O, Iverfeldt K, Nordstedt C, Suzuki T, Czernik AJ, Nairn AC, Greengard P. Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. Annals of the New York Academy of Sciences. 695: 117-21. PMID 8239268 DOI: 10.1111/j.1749-6632.1993.tb23038.x  0.84
1992 Suzuki T, Nairn AC, Gandy SE, Greengard P. Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C. Neuroscience. 48: 755-61. PMID 1630623 DOI: 10.1016/0306-4522(92)90264-3  0.84
1992 Gandy S, Greengard P. Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities Trends in Pharmacological Sciences. 13: 108-113. PMID 1574806 DOI: 10.1016/0165-6147(92)90039-9  0.84
1992 Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 3055-9. PMID 1557413 DOI: 10.1073/PNAS.89.7.3055  0.84
1992 Caporaso GL, Gandy SE, Buxbaum JD, Greengard P. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 2252-6. PMID 1549591 DOI: 10.1073/PNAS.89.6.2252  0.84
1992 Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P. The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiology of Aging. 13: 601-3. PMID 1461349 DOI: 10.1016/0197-4580(92)90063-4  0.84
1992 Gandy SE, Caporaso GL, Ramabhadran TV, Suzuki T, Buxbaum JD, Nordstedt C, Iverfeldt K, Czernik AJ, Nairn AC, Greengard P. Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. Annals of the New York Academy of Sciences. 674: 203-17. PMID 1363189 DOI: 10.1111/j.1749-6632.1992.tb27489.x  0.84
1992 Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy SE, Greengard P. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10075-8. PMID 1359534 DOI: 10.1073/PNAS.89.21.10075  0.84
1992 Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P. Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. Journal of Neurochemistry. 58: 383-6. PMID 1345769 DOI: 10.1111/j.1471-4159.1992.tb09322.x  0.84
1991 Cedarbaum JM, Gandy SE, McDowell FH. "Early" initiation of levodopa treatment does not promote the development of motor response fluctuations, dyskinesias, or dementia in Parkinson's disease. Neurology. 41: 622-9. PMID 2027475  0.84
1991 Nordstedt C, Gandy SE, Alafuzoff I, Caporaso GL, Iverfeldt K, Grebb JA, Winblad B, Greengard P. Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. Proceedings of the National Academy of Sciences of the United States of America. 88: 8910-4. PMID 1924350 DOI: 10.1073/PNAS.88.20.8910  0.84
1990 Gandy SE, Grebb JA, Rosen N, Albert KA, Devinsky O, Blumberg H, Anderson N, Cedarbaum JM, Porter RJ, Sedvall G. General assay for phosphoproteins in cerebrospinal fluid: a candidate marker for paraneoplastic cerebellar degeneration. Annals of Neurology. 28: 829-33. PMID 2285268 DOI: 10.1002/ana.410280616  0.84
1990 Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhadran TV, Unterbeck AJ, Greengard P. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 87: 6003-6. PMID 2116015 DOI: 10.1073/pnas.87.15.6003  0.84
1989 Heier LA, Zimmerman RD, Amster JL, Gandy SE, Deck MD. Magnetic resonance imaging of arachnoid cysts. Clinical Imaging. 13: 281-91. PMID 2598110 DOI: 10.1016/0899-7071(89)90061-2  0.84
1988 Feldmann E, Gandy SE, Becker R, Zimmerman R, Thaler HT, Posner JB, Plum F. MRI demonstrates descending transtentorial herniation. Neurology. 38: 697-701. PMID 3362364  0.84
1988 Gandy S, Czernik AJ, Greengard P. Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II Proceedings of the National Academy of Sciences of the United States of America. 85: 6218-6221. PMID 3137567 DOI: 10.1073/PNAS.85.16.6218  0.84
1988 Kelly AB, Zimmerman RD, Snow RB, Gandy SE, Heier LA, Deck MD. Head trauma: comparison of MR and CT--experience in 100 patients. Ajnr. American Journal of Neuroradiology. 9: 699-708. PMID 3135716  0.84
1987 Gandy SE, Heier LA. Clinical and magnetic resonance features of primary intracranial arachnoid cysts. Annals of Neurology. 21: 342-8. PMID 3579219 DOI: 10.1002/ana.410210405  0.84
1987 Goldman SA, Gandy SE. Squamous cell carcinoma as a late complication of intracerebroventricular epidermoid cyst. Case report. Journal of Neurosurgery. 66: 618-20. PMID 3559730 DOI: 10.3171/jns.1987.66.4.0618  0.84
1986 Snow RB, Zimmerman RD, Gandy SE, Deck MD. Comparison of magnetic resonance imaging and computed tomography in the evaluation of head injury. Neurosurgery. 18: 45-52. PMID 3945377  0.84
1985 Murray GJ, Youle RJ, Gandy SE, Zirzow GC, Barranger JA. Purification of beta-glucocerebrosidase by preparative-scale high-performance liquid chromatography: the use of ethylene glycol-containing buffers for chromatography of hydrophobic glycoprotein enzymes. Analytical Biochemistry. 147: 301-10. PMID 4014675 DOI: 10.1016/0003-2697(85)90276-3  0.84
1984 Gandy SE, Snow RB, Zimmerman RD, Deck MD. Cranial nuclear magnetic resonance imaging in head trauma. Annals of Neurology. 16: 254-7. PMID 6476797 DOI: 10.1002/ana.410160217  0.84
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