Samuel E. Gandy, MD PhD - Publications

Affiliations: 
Neurology and Psychiatry Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=74
Website:
http://www.mountsinai.org/profiles/samuel-e-gandy?id=0000072500003639565131

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Beckmann ND, Lin WJ, Wang M, Cohain AT, Charney AW, Wang P, Ma W, Wang YC, Jiang C, Audrain M, Comella PH, Fakira AK, Hariharan SP, Belbin GM, Girdhar K, ... ... Gandy S, et al. Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease. Nature Communications. 11: 3942. PMID 32770063 DOI: 10.1038/S41467-020-17405-Z  0.496
2020 Kritikos M, Clouston SAP, Diminich ED, Deri Y, Yang X, Carr M, Gandy S, Sano M, Bromet EJ, Luft BJ. Pathway Analysis for Plasma β-Amyloid, Tau and Neurofilament Light (ATN) in World Trade Center Responders at Midlife. Neurology and Therapy. PMID 32350803 DOI: 10.1007/S40120-020-00189-1  0.483
2020 Woo YJ, Roussos P, Haroutunian V, Katsel P, Gandy S, Schadt EE, Zhu J. Comparison of brain connectomes by MRI and genomics and its implication in Alzheimer's disease. Bmc Medicine. 18: 23. PMID 32024511 DOI: 10.1186/S12916-019-1488-1  0.407
2020 El Gaamouch F, Audrain M, Lin WJ, Beckmann N, Jiang C, Hariharan S, Heeger PS, Schadt EE, Gandy S, Ehrlich ME, Salton SR. VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice. Molecular Neurodegeneration. 15: 4. PMID 31924226 DOI: 10.1186/S13024-020-0357-X  0.511
2019 Readhead B, Haure-Mirande JV, Ehrlich ME, Gandy S, Dudley JT. Clarifying the Potential Role of Microbes in Alzheimer's Disease. Neuron. 104: 1036-1037. PMID 31855627 DOI: 10.1016/J.Neuron.2019.11.008  0.433
2019 Hata S, Omori C, Kimura A, Saito H, Kimura N, Gupta V, Pedrini S, Hone E, Chatterjee P, Taddei K, Kasuga K, Ikeuchi T, Waragai M, Nishimura M, Hu A, ... ... Gandy S, et al. Decrease in p3-Alcβ37 and p3-Alcβ40, products of Alcadein β generated by γ-secretase cleavages, in aged monkeys and patients with Alzheimer's disease. Alzheimer's & Dementia (New York, N. Y.). 5: 740-750. PMID 31754625 DOI: 10.1016/J.Trci.2019.09.015  0.462
2019 Clouston SAP, Deri Y, Diminich E, Kew R, Kotov R, Stewart C, Yang X, Gandy S, Sano M, Bromet EJ, Luft BJ. Posttraumatic stress disorder and total amyloid burden and amyloid-β 42/40 ratios in plasma: Results from a pilot study of World Trade Center responders. Alzheimer's & Dementia (Amsterdam, Netherlands). 11: 216-220. PMID 30859121 DOI: 10.1016/J.Dadm.2019.01.003  0.307
2018 Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30464330 DOI: 10.1038/S41380-018-0301-4  0.484
2018 Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden. Molecular Psychiatry. PMID 30283032 DOI: 10.1038/S41380-018-0255-6  0.413
2018 Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S. Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau. Molecular Psychiatry. PMID 30283031 DOI: 10.1038/S41380-018-0258-3  0.441
2018 Wang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, ... ... Gandy S, et al. The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease. Scientific Data. 5: 180185. PMID 30204156 DOI: 10.1038/Sdata.2018.185  0.439
2018 Moreno CL, Guardia LD, Shnyder V, Ortiz-Virumbrales M, Kruglikov I, Zhang B, Schadt EE, Tanzi RE, Noggle S, Buettner C, Gandy S. iPSC-derived familial Alzheimer's PSEN2 cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling. Molecular Neurodegeneration. 13: 33. PMID 29945658 DOI: 10.1186/S13024-018-0265-5  0.424
2018 Martins RN, Villemagne V, Sohrabi HR, Chatterjee P, Shah TM, Verdile G, Fraser P, Taddei K, Gupta VB, Rainey-Smith SR, Hone E, Pedrini S, Lim WL, Martins I, Frost S, ... ... Gandy SE, et al. Alzheimer's Disease: A Journey from Amyloid Peptides and Oxidative Stress, to Biomarker Technologies and Disease Prevention Strategies-Gains from AIBL and DIAN Cohort Studies. Journal of Alzheimer's Disease : Jad. 62: 965-992. PMID 29562546 DOI: 10.3233/Jad-171145  0.477
2018 Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nature Reviews. Neurology. PMID 29377010 DOI: 10.1038/Nrneurol.2017.185  0.33
2017 Ortiz-Virumbrales M, Moreno CL, Kruglikov I, Marazuela P, Sproul A, Jacob S, Zimmer M, Paull D, Zhang B, Schadt EE, Ehrlich ME, Tanzi RE, Arancio O, Noggle S, Gandy S. CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 (N141I) neurons. Acta Neuropathologica Communications. 5: 77. PMID 29078805 DOI: 10.1186/S40478-017-0475-Z  0.355
2017 Asih PR, Tegg ML, Sohrabi H, Carruthers M, Gandy SE, Saad F, Verdile G, Ittner LM, Martins RN. Multiple Mechanisms Linking Type 2 Diabetes and Alzheimer's Disease: Testosterone as a Modifier. Journal of Alzheimer's Disease : Jad. PMID 28655134 DOI: 10.3233/Jad-161259  0.486
2017 Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathologica. PMID 28612290 DOI: 10.1007/S00401-017-1737-3  0.521
2017 Gandy S, Bartfai T, Lees GV, Sano M. Midlife interventions are critical in prevention, delay, or improvement of Alzheimer's disease and vascular cognitive impairment and dementia. F1000research. 6: 413. PMID 28491285 DOI: 10.12688/F1000Research.11140.1  0.359
2016 Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, et al. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease. Genome Medicine. 8: 104. PMID 27799057 DOI: 10.1186/S13073-016-0355-3  0.472
2016 Kaur G, Pawlik M, Gandy SE, Ehrlich ME, Smiley JF, Levy E. Lysosomal dysfunction in the brain of a mouse model with intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein. Molecular Psychiatry. PMID 27777419 DOI: 10.1038/Mp.2016.189  0.496
2016 Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. "White Paper" meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction. F1000research. 5: 353. PMID 27303627 DOI: 10.12688/F1000Research.8300.2  0.306
2016 Knight EM, Kim SH, Kottwitz JC, Hatami A, Albay R, Suzuki A, Lublin A, Alberini CM, Klein WL, Szabo P, Relkin NR, Ehrlich M, Glabe CG, Gandy S, Steele JW. Effective anti-Alzheimer Aβ therapy involves depletion of specific Aβ oligomer subtypes. Neurology® Neuroimmunology & Neuroinflammation. 3: e237. PMID 27218118 DOI: 10.1212/Nxi.0000000000000237  0.689
2016 Bates KA, Sohrabi HR, Rainey-Smith SR, Weinborn M, Bucks Rs RS, Rodrigues M, Beilby J, Howard M, Taddei K, Martins G, A AP, Shah T, Dhaliwal SS, Foster JK, Martins IJ, ... ... Gandy S, et al. Serum high-density lipoprotein is associated with better cognitive function in a cross-sectional study of aging women. The International Journal of Neuroscience. 1-31. PMID 27113638 DOI: 10.1080/00207454.2016.1182527  0.329
2016 Sano M, Gandy S. Sex differences in cognition Does the “fairer sex” need a fairer test? Neurology. 86: 1364-1365. PMID 26984948 DOI: 10.1212/Wnl.0000000000002573  0.343
2016 Ruiz HH, Chi T, Lindtner C, Hsieh W, Ehrlich M, Gandy S, Buettner C. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26928090 DOI: 10.1016/J.Jalz.2016.01.008  0.319
2016 Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathologica Communications. 4: 16. PMID 26916443 DOI: 10.1186/S40478-016-0282-Y  0.479
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin J, Abeliovich H, Arozena AA, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gandy S, et al. Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356 Autophagy. 12: 443-443. PMID 26902590 DOI: 10.1080/15548627.2016.1147886  0.553
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gandy S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.575
2016 Stoeckel LE, Arvanitakis Z, Gandy S, Small D, Kahn CR, Pascual-Leone A, Pawlyk A, Sherwin R, Smith P. “White Paper” meeting summary and catalyst for future inquiry: Complex mechanisms linking neurocognitive dysfunction to insulin resistance and other metabolic dysfunction F1000research. 5: 353. DOI: 10.12688/F1000Research.8300.1  0.305
2015 Hunsberger JG, Rao M, Kurtzberg J, Bulte JW, Atala A, LaFerla FM, Greely HT, Sawa A, Gandy S, Schneider LS, Doraiswamy PM. Accelerating stem cell trials for Alzheimer's disease. The Lancet. Neurology. PMID 26704439 DOI: 10.1016/S1474-4422(15)00332-4  0.376
2015 Brautigam H, Moreno CL, Steele JW, Bogush A, Dickstein DL, Kwok JB, Schofield PR, Thinakaran G, Mathews PM, Hof PR, Gandy S, Ehrlich ME. Physiologically generated presenilin 1 lacking exon 8 fails to rescue brain PS1-/- phenotype and forms complexes with wildtype PS1 and nicastrin. Scientific Reports. 5: 17042. PMID 26608390 DOI: 10.1038/Srep17042  0.762
2015 Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology. Molecular Psychiatry. PMID 26552589 DOI: 10.1038/Mp.2015.167  0.438
2015 Gandy S, Sano M. Alzheimer disease: Solanezumab-prospects for meaningful interventions in AD? Nature Reviews. Neurology. 11: 669-70. PMID 26526537 DOI: 10.1038/Nrneurol.2015.218  0.434
2015 Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 112: 11965-70. PMID 26372964 DOI: 10.1073/Pnas.1510011112  0.49
2015 Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. Molecular Psychiatry. 20: 109-17. PMID 25349165 DOI: 10.1038/Mp.2014.135  0.664
2014 Kim SH, Steele JW, Lee SW, Clemenson GD, Carter TA, Treuner K, Gadient R, Wedel P, Glabe C, Barlow C, Ehrlich ME, Gage FH, Gandy S. Proneurogenic Group II mGluR antagonist improves learning and reduces anxiety in Alzheimer Aβ oligomer mouse. Molecular Psychiatry. 19: 1235-42. PMID 25113378 DOI: 10.1038/Mp.2014.87  0.669
2014 Simon RA, Shirani H, Aslund KO, Bäck M, Haroutunian V, Gandy S, Nilsson KP. Pentameric thiophene-based ligands that spectrally discriminate amyloid-β and tau aggregates display distinct solvatochromism and viscosity-induced spectral shifts. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 12537-43. PMID 25111601 DOI: 10.1002/Chem.201402890  0.456
2014 Knight EM, Gandy S. Immunomodulation and AD--down but not out. Journal of Clinical Immunology. 34: S70-3. PMID 24781637 DOI: 10.1007/s10875-014-0039-y  0.372
2014 Feldman HH, Haas M, Gandy S, Schoepp DD, Cross AJ, Mayeux R, Sperling RA, Fillit H, van de Hoef DL, Dougal S, Nye JS. Alzheimer's disease research and development: a call for a new research roadmap. Annals of the New York Academy of Sciences. 1313: 1-16. PMID 24754377 DOI: 10.1111/Nyas.12424  0.399
2014 Dekosky ST, Gandy S. Environmental exposures and the risk for Alzheimer disease: can we identify the smoking guns? Jama Neurology. 71: 273-5. PMID 24473699 DOI: 10.1001/Jamaneurol.2013.6031  0.331
2014 Sproul AA, Jacob S, Pre D, Kim SH, Nestor MW, Navarro-Sobrino M, Santa-Maria I, Zimmer M, Aubry S, Steele JW, Kahler DJ, Dranovsky A, Arancio O, Crary JF, Gandy S, et al. Characterization and molecular profiling of PSEN1 familial Alzheimer's disease iPSC-derived neural progenitors. Plos One. 9: e84547. PMID 24416243 DOI: 10.1371/Journal.Pone.0084547  0.655
2014 Steele JW, Brautigam H, Short JA, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer's disease mouse model. The Journal of Comparative Neurology. 522: 2319-35. PMID 24415002 DOI: 10.1002/Cne.23536  0.786
2014 Gandy S. Alzheimer's disease: new data highlight nonneuronal cell types and the necessity for presymptomatic prevention strategies. Biological Psychiatry. 75: 553-7. PMID 24373429 DOI: 10.1016/J.Biopsych.2013.11.019  0.455
2013 Bharadwaj PR, Bates KA, Porter T, Teimouri E, Perry G, Steele JW, Gandy S, Groth D, Martins RN, Verdile G. Latrepirdine: molecular mechanisms underlying potential therapeutic roles in Alzheimer's and other neurodegenerative diseases. Translational Psychiatry. 3: e332. PMID 24301650 DOI: 10.1038/Tp.2013.97  0.675
2013 Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D. Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model. The Journal of Biological Chemistry. 288: 32050-63. PMID 24052255 DOI: 10.1074/Jbc.M113.504365  0.418
2013 Gandy S, Heppner FL. Microglia as dynamic and essential components of the amyloid hypothesis. Neuron. 78: 575-7. PMID 23719156 DOI: 10.1016/J.Neuron.2013.05.007  0.394
2013 Lane RF, Steele JW, Cai D, Ehrlich ME, Attie AD, Gandy S. Protein sorting motifs in the cytoplasmic tail of SorCS1 control generation of Alzheimer's amyloid-β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7099-107. PMID 23595767 DOI: 10.1523/Jneurosci.5270-12.2013  0.724
2013 Gandy S, Haroutunian V, DeKosky ST, Sano M, Schadt EE. CR1 and the "vanishing amyloid" hypothesis of Alzheimer's disease. Biological Psychiatry. 73: 393-5. PMID 23399469 DOI: 10.1016/J.Biopsych.2013.01.013  0.41
2013 Steele JW, Gandy S. Latrepirdine (Dimebon®), a potential Alzheimer therapeutic, regulates autophagy and neuropathology in an Alzheimer mouse model. Autophagy. 9: 617-8. PMID 23380933 DOI: 10.4161/Auto.23487  0.725
2013 Gandy S, DeKosky ST. Toward the treatment and prevention of Alzheimer's disease: rational strategies and recent progress. Annual Review of Medicine. 64: 367-83. PMID 23327526 DOI: 10.1146/Annurev-Med-092611-084441  0.538
2013 Gandy S, DeKosky ST. 2012: the year in dementia. The Lancet. Neurology. 12: 4-6. PMID 23237888 DOI: 10.1016/S1474-4422(12)70284-3  0.525
2013 Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Gandy S, et al. Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 18: 882-8. PMID 22869031 DOI: 10.1038/Mp.2012.115  0.663
2013 Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, ... ... Gandy S, et al. Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model. Molecular Psychiatry. 18: 889-97. PMID 22850627 DOI: 10.1038/Mp.2012.106  0.668
2013 Knight E, Szabo P, Ehrlich M, Relkin N, Gandy S. Neat, but not beta-amyloid–affinity-depleted, Baxter Immune Globulin® modulates behavior in transgenic mouse expressing Dutch beta-amyloid oligomers Alzheimers & Dementia. 9: 885. DOI: 10.1016/J.Jalz.2013.08.242  0.329
2013 Mitsis E, Riggio S, D'Antonio E, Goldstein M, DeKosky S, Naidich T, Delman B, Machac J, Elder G, Sano M, Gandy S, Gordon W. Florbetapir scanning excludes Alzheimer's disease in a retired NFL player with delayed cognitive impairment Alzheimers & Dementia. 9: 373. DOI: 10.1016/J.Jalz.2013.05.726  0.385
2013 Mitsis E, Bender H, Kostakoglu L, Machac J, Martin J, Woehr J, Goldstein M, Sano M, Gandy S. Florbetapir F18 PET identification of beta-amyloid in the living brain: A consecutive clinical case series Alzheimers & Dementia. 9: 373. DOI: 10.1016/J.Jalz.2013.05.725  0.324
2012 Kim SH, Knight EM, Saunders EL, Cuevas AK, Popovech M, Chen LC, Gandy S. Rapid doubling of Alzheimer's amyloid-β40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution. F1000research. 1: 70. PMID 24358824 DOI: 10.12688/F1000Research.1-70.V1  0.428
2012 De Gasperi R, Gama Sosa MA, Kim SH, Steele JW, Shaughness MC, Maudlin-Jeronimo E, Hall AA, Dekosky ST, McCarron RM, Nambiar MP, Gandy S, Ahlers ST, Elder GA. Acute blast injury reduces brain abeta in two rodent species. Frontiers in Neurology. 3: 177. PMID 23267342 DOI: 10.3389/Fneur.2012.00177  0.601
2012 Brautigam H, Steele JW, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. The isotropic fractionator provides evidence for differential loss of hippocampal neurons in two mouse models of Alzheimer's disease. Molecular Neurodegeneration. 7: 58. PMID 23173713 DOI: 10.1186/1750-1326-7-58  0.795
2012 Lane RF, St George-Hyslop P, Hempstead BL, Small SA, Strittmatter SM, Gandy S. Vps10 family proteins and the retromer complex in aging-related neurodegeneration and diabetes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14080-6. PMID 23055476 DOI: 10.1523/Jneurosci.3359-12.2012  0.358
2012 Zhu L, Su M, Lucast L, Liu L, Netzer WJ, Gandy SE, Cai D. Dynamin 1 regulates amyloid generation through modulation of BACE-1. Plos One. 7: e45033. PMID 23024787 DOI: 10.1371/Journal.Pone.0045033  0.511
2012 Gandy S. Lifelong management of amyloid-beta metabolism to prevent Alzheimer's disease. The New England Journal of Medicine. 367: 864-6. PMID 22931321 DOI: 10.1056/NEJMe1207995  0.338
2012 Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, et al. Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast. Journal of Alzheimer's Disease : Jad. 32: 949-67. PMID 22903131 DOI: 10.3233/Jad-2012-120178  0.675
2012 Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Sohrabi HR, Martins RN, Gandy S, Urakami K, Suzuki T. Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. Molecular Neurodegeneration. 7: 16. PMID 22534039 DOI: 10.1186/1750-1326-7-16  0.318
2012 Caesar I, Gandy S. Evidence that an APOE ε4 'double whammy' increases risk for Alzheimer's disease. Bmc Medicine. 10: 36. PMID 22502767 DOI: 10.1186/1741-7015-10-36  0.421
2012 Keilani S, Lun Y, Stevens AC, Williams HN, Sjoberg ER, Khanna R, Valenzano KJ, Checler F, Buxbaum JD, Yanagisawa K, Lockhart DJ, Wustman BA, Gandy S. Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5223-36. PMID 22496568 DOI: 10.1523/JNEUROSCI.4860-11.2012  0.446
2012 Sproul AA, Jacob S, Nestor MW, Keilani S, Jean Y, Kahler DJ, Santa-Maria I, Steele J, Crary JF, Troy CM, Gandy S, Noggle SA. S5-01-02: Development of an induced pluripotent stem cell (iPSC) Alzheimer's disease model using PSEN1 mutant fibroblasts Alzheimer's & Dementia. 8: P724-P724. DOI: 10.1016/J.Jalz.2012.05.1945  0.626
2011 Konno T, Hata S, Hamada Y, Horikoshi-Sakuraba Y, Nakaya T, Saito Y, Yamamoto T, Yamamoto T, Maeda M, Ikeuchi T, Gandy S, Akatsu H, Suzuki T. Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system. Molecular Neurodegeneration. 6: 76. PMID 22067061 DOI: 10.1186/1750-1326-6-76  0.335
2011 Gandy S. Perspective: prevention is better than cure. Nature. 475: S15. PMID 21760576 DOI: 10.1038/475S15A  0.367
2011 Costanza A, Weber K, Gandy S, Bouras C, Hof PR, Giannakopoulos P, Canuto A. Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates. Neuropathology and Applied Neurobiology. 37: 570-84. PMID 21696410 DOI: 10.1111/J.1365-2990.2011.01186.X  0.429
2011 Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Gandy S, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/Ana.22343  0.44
2011 Sohrabi HR, Weinborn M, Badcock J, Bates KA, Clarnette R, Trivedi D, Verdile G, Sutton T, Lenzo NP, Gandy SE, Martins RN. New lexicon and criteria for the diagnosis of Alzheimer's disease. The Lancet. Neurology. 10: 299-300; author repl. PMID 21435594 DOI: 10.1016/S1474-4422(11)70056-4  0.351
2011 Steele JW, Gandy S. Apomorphine and Alzheimer Aβ: roles for regulated α cleavage, autophagy, and antioxidation? Annals of Neurology. 69: 221-5. PMID 21387363 DOI: 10.1002/Ana.22359  0.708
2011 Gandy S, Wustman B. New pathway links γ-secretase to inflammation and memory while sparing notch. Annals of Neurology. 69: 5-7. PMID 21280069 DOI: 10.1002/Ana.22310  0.506
2011 Saksena S, Lun Y, Keilani S, Williams H, Stevens A, Sjoberg E, Khanna R, Valenzano K, Lockhart D, Gandy S, Wustman B. Lysosomal dysfunction in gangliosidoses results in secondary accumulation of proteins associated with neurodegeneration Molecular Genetics and Metabolism. 102: S39. DOI: 10.1016/J.Ymgme.2010.11.132  0.332
2011 Hata S, Urakami K, Taniguchi M, Akatsu H, Gandy S, Suzuki T. P3-189: Alternative gamma-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of alcadein Alzheimer's & Dementia. 7: S577-S577. DOI: 10.1016/J.Jalz.2011.05.1630  0.377
2011 Haroutunian V, Beeri MS, Sano M, Gandy S, Purohit D, Maroukian M, Katsel P. Oligomeric abeta associated with dementia in young-old and oldest-old persons Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1161  0.36
2011 Lane R, Attie A, Ehrlich M, Gandy S. P2-240: The diabetes associated protein, SorCS1 regulates APP metabolism Alzheimer's & Dementia. 7: S388-S389. DOI: 10.1016/J.Jalz.2011.05.1123  0.301
2011 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-β metabolism: Evidence for involvement of SorL1 and the retromer complex (Journal of Neuroscience (2010) (13110-13115)) Journal of Neuroscience. 31.  0.617
2010 Lane RF, Gatson JW, Small SA, Ehrlich ME, Gandy S. Protein kinase C and rho activated coiled coil protein kinase 2 (ROCK2) modulate Alzheimer's APP metabolism and phosphorylation of the Vps10-domain protein, SorL1. Molecular Neurodegeneration. 5: 62. PMID 21192821 DOI: 10.1186/1750-1326-5-62  0.468
2010 Vieira SI, Rebelo S, Esselmann H, Wiltfang J, Lah J, Lane R, Small SA, Gandy S, da Cruz E Silva EF, da Cruz E Silva OA. Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated. Molecular Neurodegeneration. 5: 40. PMID 20937087 DOI: 10.1186/1750-1326-5-40  0.813
2010 Lane RF, Raines SM, Steele JW, Ehrlich ME, Lah JA, Small SA, Tanzi RE, Attie AD, Gandy S. Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13110-5. PMID 20881129 DOI: 10.1523/Jneurosci.3872-10.2010  0.725
2010 Gandy S, Simon AJ, Steele JW, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Checler F, Glabe C, Bilker WB, Abel T, Schmeidler J, Ehrlich ME. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomers. Annals of Neurology. 68: 220-30. PMID 20641005 DOI: 10.1002/Ana.22052  0.682
2010 Sharman MJ, Morici M, Hone E, Berger T, Taddei K, Martins IJ, Lim WL, Singh S, Wenk MR, Ghiso J, Buxbaum JD, Gandy S, Martins RN. APOE genotype results in differential effects on the peripheral clearance of amyloid-beta42 in APOE knock-in and knock-out mice. Journal of Alzheimer's Disease : Jad. 21: 403-9. PMID 20555142 DOI: 10.3233/Jad-2010-100141  0.349
2010 Jenner AM, Lim WL, Ng MP, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience. 169: 109-15. PMID 20416362 DOI: 10.1016/J.Neuroscience.2010.04.026  0.346
2010 Kim SH, Fraser PE, Westaway D, St George-Hyslop PH, Ehrlich ME, Gandy S. Group II metabotropic glutamate receptor stimulation triggers production and release of Alzheimer's amyloid(beta)42 from isolated intact nerve terminals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3870-5. PMID 20237257 DOI: 10.1523/Jneurosci.4717-09.2010  0.473
2010 Kajiwara Y, Franciosi S, Takahashi N, Krug L, Schmeidler J, Taddei K, Haroutunian V, Fried U, Ehrlich M, Martins RN, Gandy S, Buxbaum JD. Extensive proteomic screening identifies the obesity-related NYGGF4 protein as a novel LRP1-interactor, showing reduced expression in early Alzheimer's disease. Molecular Neurodegeneration. 5: 1. PMID 20205790 DOI: 10.1186/1750-1326-5-1  0.423
2010 Gandy S. Testing the amyloid hypothesis of Alzheimer's disease in vivo. The Lancet. Neurology. 9: 333-5. PMID 20189880 DOI: 10.1016/S1474-4422(10)70055-7  0.481
2010 Sharman MJ, Shui G, Fernandis AZ, Lim WL, Berger T, Hone E, Taddei K, Martins IJ, Ghiso J, Buxbaum JD, Gandy S, Wenk MR, Martins RN. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry. Journal of Alzheimer's Disease : Jad. 20: 105-11. PMID 20164599 DOI: 10.3233/Jad-2010-1348  0.341
2010 Lublin AL, Gandy S. Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. The Mount Sinai Journal of Medicine, New York. 77: 43-9. PMID 20101723 DOI: 10.1002/Msj.20160  0.474
2010 Dickstein DL, Walsh J, Brautigam H, Stockton SD, Gandy S, Hof PR. Role of vascular risk factors and vascular dysfunction in Alzheimer's disease. The Mount Sinai Journal of Medicine, New York. 77: 82-102. PMID 20101718 DOI: 10.1002/Msj.20155  0.716
2010 Brautigam H, Klingstedt T, Prokop S, Holtzman DM, Heppner FL, Haroutunian V, Dickstein DL, Hof PR, Nilsson PR, Gandy S. O4-08-06: New Conformation-Sensing Imaging Compounds Distinguish Protein Deposits In Apoe ε3/ε3 Alzheimer's Patients From that in Apoe ε4/ε4 Alzheimer's Patients Alzheimer's & Dementia. 6: e19-e20. DOI: 10.1016/J.Jalz.2010.08.059  0.706
2010 Florence Lim WL, Jenner AM, Ern Ng MP, Wenk MR, Shui G, Sharman MJ, Gandy SE, Martins RN. P1-283: The effect of APOE genotype on brain levels of oxysterols in young and old human APOE ∊2, ∊3 and ∊4 knock-in mice Alzheimer's & Dementia. 6: S255-S256. DOI: 10.1016/J.Jalz.2010.05.835  0.314
2010 Lane RF, Raines SM, Levey A, Lah JJ, Small SA, Tanzi RE, Attie AD, Gandy SE. Diabetes-linked SORCS1, a gamma-secretase substrate and regulator of Alzheimer APP metabolism, forms complexes with multiple Alzheimer-linked proteins (APP, PS1, BACE, VPS35, and SORLA) Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.814  0.461
2010 Steele JW, Simon AJ, Lublin AL, Lah JJ, Walker LC, Levey AI, Krafft GA, Levy E, Glabe C, Bilker W, Abel T, Schmeidler J, Ehrlich ME, Gandy S. Evidence for dose-dependent neurotoxicity of amyloid-β oligomers/Aβ-derived diffusible ligands generated from physiological processing of transgenic human APP in situ in mouse brain Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.737  0.651
2010 Hata S, Urakami K, Fagan A, Peskind E, Akatsu H, Maeda M, Levey A, Chung KA, Montine T, Leverenz J, Goate A, Bateman R, Holtzman DM, Gandy S, Suzuki T. P3-171: Gamma-secretase dysfunction in sporadic Alzhemer's disease suggested by p3-Alc peptide, metabolic product of Alcadein Alzheimer's & Dementia. 6: S499-S500. DOI: 10.1016/J.Jalz.2010.05.1669  0.319
2010 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia Neuroforum. 16: 164-167.  0.391
2009 Steele JW, Kim SH, Cirrito JR, Verges DK, Restivo JL, Westaway D, Fraser P, Hyslop PS, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM, Gandy S. Acute dosing of latrepirdine (Dimebon), a possible Alzheimer therapeutic, elevates extracellular amyloid-beta levels in vitro and in vivo. Molecular Neurodegeneration. 4: 51. PMID 20017949 DOI: 10.1186/1750-1326-4-51  0.695
2009 Kaufer D, Gandy S. APOE {epsilon}4 and bapineuzumab: Infusing pharmacogenomics into Alzheimer disease therapeutics. Neurology. 73: 2052-3. PMID 19923549 DOI: 10.1212/Wnl.0B013E3181C6784A  0.496
2009 Hata S, Fujishige S, Araki Y, Kato N, Araseki M, Nishimura M, Hartmann D, Saftig P, Fahrenholz F, Taniguchi M, Urakami K, Akatsu H, Martins RN, Yamamoto K, Maeda M, ... ... Gandy S, et al. Alcadein cleavages by amyloid beta-precursor protein (APP) alpha- and gamma-secretases generate small peptides, p3-Alcs, indicating Alzheimer disease-related gamma-secretase dysfunction. The Journal of Biological Chemistry. 284: 36024-33. PMID 19864413 DOI: 10.1074/Jbc.M109.057497  0.422
2009 Pedrini S, Thomas C, Brautigam H, Schmeidler J, Ho L, Fraser P, Westaway D, Hyslop PS, Martins RN, Buxbaum JD, Pasinetti GM, Dickstein DL, Hof PR, Ehrlich ME, Gandy S. Dietary composition modulates brain mass and solubilizable Abeta levels in a mouse model of aggressive Alzheimer's amyloid pathology. Molecular Neurodegeneration. 4: 40. PMID 19845940 DOI: 10.1186/1750-1326-4-40  0.745
2009 Grathwohl SA, Kälin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, et al. Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nature Neuroscience. 12: 1361-3. PMID 19838177 DOI: 10.1515/Nf-2010-0107  0.516
2009 Aslund A, Sigurdson CJ, Klingstedt T, Grathwohl S, Bolmont T, Dickstein DL, Glimsdal E, Prokop S, Lindgren M, Konradsson P, Holtzman DM, Hof PR, Heppner FL, Gandy S, Jucker M, et al. Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses. Acs Chemical Biology. 4: 673-84. PMID 19624097 DOI: 10.1021/Cb900112V  0.473
2009 Gandy S. An interview with Samuel Gandy, MD, PhD: Alzheimer's disease by Norman Sussman. Cns Spectrums. 14: 248-51. PMID 19489174  0.328
2009 Bates KA, Sohrabi HR, Rodrigues M, Beilby J, Dhaliwal SS, Taddei K, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager NT, ... ... Gandy SE, et al. Association of cardiovascular factors and Alzheimer's disease plasma amyloid-beta protein in subjective memory complainers. Journal of Alzheimer's Disease : Jad. 17: 305-18. PMID 19363264 DOI: 10.3233/Jad-2009-1050  0.477
2009 Boyd JL, Casson I, DeKosky S, Feuer H, Gandy S, Khachaturian Z, Kinoshita J, Marchesi V, McKee A, Nowinski C, Perl D, Purohit D, Relkin N, Smith MA, Strobel G, et al. Alzheimer research forum live discussion: Sports concussions, dementia, and ApoE genotyping: What can scientists tell the public? What's up for research? Journal of Alzheimer's Disease. 16: 657-666. PMID 19276560 DOI: 10.3233/Jad-2009-1014  0.337
2009 Sakuma M, Tanaka E, Taru H, Tomita S, Gandy S, Nairn AC, Nakaya T, Yamamoto T, Suzuki T. Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP. Journal of Neurochemistry. 109: 465-75. PMID 19222704 DOI: 10.1111/J.1471-4159.2009.05988.X  0.347
2009 Amadio M, Pascale A, Wang J, Ho L, Quattrone A, Gandy S, Haroutunian V, Racchi M, Pasinetti GM. nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing. Journal of Alzheimer's Disease : Jad. 16: 409-19. PMID 19221430 DOI: 10.3233/Jad-2009-0967  0.538
2009 da Cruz e Silva OA, Rebelo S, Vieira SI, Gandy S, da Cruz e Silva EF, Greengard P. Enhanced generation of Alzheimer's amyloid-beta following chronic exposure to phorbol ester correlates with differential effects on alpha and epsilon isozymes of protein kinase C. Journal of Neurochemistry. 108: 319-30. PMID 19012746 DOI: 10.1111/J.1471-4159.2008.05770.X  0.805
2009 Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy SE, Gibson GE. Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model. Neurobiology of Aging. 30: 1587-600. PMID 18406011 DOI: 10.1016/J.Neurobiolaging.2007.12.013  0.383
2009 Gandy S, Cirrito J, Steele J, Kim SH, Thinakaran G, Westaway D, Fraser P, St George Hyslop P, Sano M, Bezprozvanny I, Ehrlich ME, Holtzman DM. S4-04-06: Dimebon®: A Clinically Promising Drug for Alzheimer's Disease, Regulates Amyloid-Beta Metabolism in Cultured Cells, In Isolated Nerve Terminals, and In the Interstitial Fluid of the Living Rodent Brain Alzheimer's & Dementia. 5: e5-e5. DOI: 10.1016/J.Jalz.2009.07.133  0.66
2009 Gandy SE, Hata S, Fujishige S, Araki Y, Kato N, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Saftig P, Hartmann D, Fahrenholz F, Yamamoto K, Martins RN, et al. O1-06-07: Misprocessing of Multiple Transmembrane Substrates Reveals Gamma-Secretase Dysfunction in Both Familial and Sporadic Alzheimer's Diseases Alzheimer's & Dementia. 5: e3-e3. DOI: 10.1016/J.Jalz.2009.07.125  0.372
2009 Hata S, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Fagan A, Goate A, Bateman R, Holtzman DM, Nakaya T, Gandy S, Suzuki T. P2-190: p3-Alc peptides produced by covariant processing of Alcadein and APP implicate γ-secretase dysfunction in sporadic Alzheimer's disease Alzheimer's & Dementia. 5: P316-P317. DOI: 10.1016/J.Jalz.2009.04.502  0.402
2008 Qin W, Zhao W, Ho L, Wang J, Walsh K, Gandy S, Pasinetti GM. Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration. Annals of the New York Academy of Sciences. 1147: 335-47. PMID 19076455 DOI: 10.1196/Annals.1427.024  0.497
2008 Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. The Journal of Biological Chemistry. 283: 35763-71. PMID 18845544 DOI: 10.1074/Jbc.M801353200  0.444
2008 Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, et al. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation. 5: 36. PMID 18715507 DOI: 10.1186/1742-2094-5-36  0.451
2008 Bates KA, Sohrabi HR, Rodrigues M, De Ruyck K, Beilby J, Dhaliwal SS, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager NT, ... ... Gandy SE, et al. P1-342: Relationship between cardiovascular disease risk factors and Alzheimer's disease Aβ protein in subjective memory complainers Alzheimer's & Dementia. 4: T319-T319. DOI: 10.1016/J.Jalz.2008.05.923  0.436
2008 Gandy S. PL-02-02: Amyloid precursor sorting and processing: Regulation by transmitters, hormones, and protein phosphorylation mechanisms Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.266  0.391
2007 Ikin AF, Causevic M, Pedrini S, Benson LS, Buxbaum JD, Suzuki T, Lovestone S, Higashiyama S, Mustelin T, Burgoyne RD, Gandy S. Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding. Molecular Neurodegeneration. 2: 23. PMID 18067682 DOI: 10.1186/1750-1326-2-23  0.321
2007 Gandy S, Zhang YW, Ikin A, Schmidt SD, Bogush A, Levy E, Sheffield R, Nixon RA, Liao FF, Mathews PM, Xu H, Ehrlich ME. Alzheimer's presenilin 1 modulates sorting of APP and its carboxyl-terminal fragments in cerebral neurons in vivo. Journal of Neurochemistry. 102: 619-26. PMID 17630980 DOI: 10.1111/J.1471-4159.2007.04587.X  0.381
2007 Verdile G, Gandy SE, Martins RN. The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid. Neurochemical Research. 32: 609-23. PMID 16944319 DOI: 10.1007/S11064-006-9131-X  0.346
2006 Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T. Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP. Plos One. 1: e51. PMID 17183681 DOI: 10.1371/Journal.Pone.0000051  0.394
2006 Qin W, Chachich M, Lane M, Roth G, Bryant M, de Cabo R, Ottinger MA, Mattison J, Ingram D, Gandy S, Pasinetti GM. Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus). Journal of Alzheimer's Disease : Jad. 10: 417-22. PMID 17183154 DOI: 10.3233/Jad-2006-10411  0.394
2006 Gandy S, Doeven MK, Poolman B. Alzheimer disease: presenilin springs a leak. Nature Medicine. 12: 1121-3. PMID 17024202 DOI: 10.1038/Nm1006-1121  0.404
2006 Small SA, Gandy S. Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron. 52: 15-31. PMID 17015224 DOI: 10.1016/j.neuron.2006.09.001  0.341
2006 Martins IJ, Hone E, Foster JK, Sünram-Lea SI, Gnjec A, Fuller SJ, Nolan D, Gandy SE, Martins RN. Apolipoprotein E, cholesterol metabolism, diabetes, and the convergence of risk factors for Alzheimer's disease and cardiovascular disease. Molecular Psychiatry. 11: 721-36. PMID 16786033 DOI: 10.1038/Sj.Mp.4001854  0.331
2006 Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, et al. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. The Journal of Biological Chemistry. 281: 21745-54. PMID 16751189 DOI: 10.1074/Jbc.M602909200  0.416
2005 Balakrishnan K, Verdile G, Mehta PD, Beilby J, Nolan D, Galvão DA, Newton R, Gandy SE, Martins RN. Plasma Abeta42 correlates positively with increased body fat in healthy individuals. Journal of Alzheimer's Disease : Jad. 8: 269-82. PMID 16340084 DOI: 10.3233/Jad-2005-8305  0.308
2005 Hone E, Martins IJ, Jeoung M, Ji TH, Gandy SE, Martins RN. Alzheimer's disease amyloid-beta peptide modulates apolipoprotein E isoform specific receptor binding. Journal of Alzheimer's Disease : Jad. 7: 303-14. PMID 16131732 DOI: 10.3233/Jad-2005-7406  0.393
2004 Ghiso J, Shayo M, Calero M, Ng D, Tomidokoro Y, Gandy S, Rostagno A, Frangione B. Systemic catabolism of Alzheimer's Abeta40 and Abeta42. The Journal of Biological Chemistry. 279: 45897-908. PMID 15322125 DOI: 10.1074/Jbc.M407668200  0.35
2004 Verdile G, Fuller S, Atwood CS, Laws SM, Gandy SE, Martins RN. The role of beta amyloid in Alzheimer's disease: still a cause of everything or the only one who got caught? Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 50: 397-409. PMID 15304237 DOI: 10.1016/J.Phrs.2003.12.028  0.356
2003 Thomas EA, Laws SM, Sutcliffe JG, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype. Biological Psychiatry. 54: 136-41. PMID 12873803 DOI: 10.1016/S0006-3223(02)01976-5  0.347
2003 Kwok JB, Halliday GM, Brooks WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vickers J, Wang R, Naslund J, Takashima A, Gandy SE, Schofield PR. Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. The Journal of Biological Chemistry. 278: 6748-54. PMID 12493737 DOI: 10.1074/Jbc.M211827200  0.348
2003 Lilliehook C, Bozdagi O, Yao J, Gomez-Ramirez M, Zaidi NF, Wasco W, Gandy S, Santucci AC, Haroutunian V, Huntley GW, Buxbaum JD. Altered Aβ Formation and Long-Term Potentiation in a Calsenilin Knock-Out The Journal of Neuroscience. 23: 9097-9106. DOI: 10.1523/Jneurosci.23-27-09097.2003  0.361
2002 Laws SM, Hone E, Taddei K, Harper C, Dean B, McClean C, Masters C, Lautenschlager N, Gandy SE, Martins RN. Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E. Molecular Psychiatry. 7: 886-90. PMID 12232782 DOI: 10.1038/Sj.Mp.4001097  0.331
2000 Petanceska SS, Nagy V, Frail D, Gandy S. Ovariectomy and 17β-estradiol modulate the levels of Alzheimer's amyloid β peptides in brain Experimental Gerontology. 35: 1317-1325. PMID 11113610 DOI: 10.1016/S0531-5565(00)00157-1  0.388
2000 Gandy S, Duff K. Post-menopausal estrogen deprivation and Alzheimer's disease. Experimental Gerontology. 35: 503-11. PMID 10959038 DOI: 10.1016/S0531-5565(00)00116-9  0.422
1998 Calingasan NY, Park LC, Gandy SE, Gibson GE. Disturbances of the blood-brain barrier without expression of amyloid precursor protein- containing neuritic clusters or neuronal loss during late stages of thiamine deficiency in guinea pigs. Developmental Neuroscience. 20: 454-61. PMID 9778584 DOI: 10.1159/000017343  0.341
1997 Calingasan NY, Gandy SE, Gibson GE. Thiamine deficiency alters APP but not presenilin-1 immunoreactivity in vulnerable brain regions. Neuroreport. 8: 2631-4. PMID 9261840  0.366
1997 Suzuki T, Ando K, Isohara T, Oishi M, Lim GS, Satoh Y, Wasco W, Tanzi RE, Nairn AC, Greengard P, Gandy SE, Kirino Y. Phosphorylation of Alzheimer beta-amyloid precursor-like proteins. Biochemistry. 36: 4643-9. PMID 9109675 DOI: 10.1021/Bi962618K  0.432
1997 Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T. The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells. Molecular Medicine (Cambridge, Mass.). 3: 111-23. PMID 9085254  0.384
1997 Tjernberg LO, Näslund J, Thyberg J, Gandy SE, Terenius L, Nordstedt C. Generation of Alzheimer amyloid beta peptide through nonspecific proteolysis. The Journal of Biological Chemistry. 272: 1870-5. PMID 8999874 DOI: 10.1074/Jbc.272.3.1870  0.314
1997 Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T. The Cytoplasmic Domain of Alzheimer’s Amyloid Precursor Protein Is Phosphorylated at Thr654, Ser655, and Thr668 in Adult Rat Brain and Cultured Cells Molecular Medicine. 3: 111-123. DOI: 10.1007/Bf03401803  0.429
1996 Wang R, Sweeney D, Gandy SE, Sisodia SS. The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. The Journal of Biological Chemistry. 271: 31894-902. PMID 8943233 DOI: 10.1074/jbc.271.50.31894  0.344
1996 Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5  0.407
1996 Calingasan NY, Gandy SE, Baker H, Sheu KF, Smith JD, Lamb BT, Gearhart JD, Buxbaum JD, Harper C, Selkoe DJ, Price DL, Sisodia SS, Gibson GE. Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency. The American Journal of Pathology. 149: 1063-71. PMID 8780408  0.367
1996 Zhou Z, Smith JD, Greengard P, Gandy S. Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E Molecular Medicine. 2: 175-180. DOI: 10.1007/BF03401614  0.452
1995 Näslund J, Thyberg J, Tjernberg LO, Wernstedt C, Karlström AR, Bogdanovic N, Gandy SE, Lannfelt L, Terenius L, Nordstedt C. Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer's disease brain. Neuron. 15: 219-28. PMID 7619525 DOI: 10.1016/0896-6273(95)90079-9  0.391
1995 Calingasan NY, Gandy SE, Baker H, Sheu KF, Kim KS, Wisniewski HM, Gibson GE. Accumulation of amyloid precursor protein-like immunoreactivity in rat brain in response to thiamine deficiency. Brain Research. 677: 50-60. PMID 7606469 DOI: 10.1016/0006-8993(95)00136-E  0.381
1995 Price DL, Sisodia SS, Gandy SE. Amyloid beta amyloidosis in Alzheimer's disease. Current Opinion in Neurology. 8: 268-74. PMID 7582041 DOI: 10.1097/00019052-199508000-00004  0.398
1995 Martins RN, Clarnette R, Fisher C, Broe GA, Brooks WS, Montgomery P, Gandy SE. ApoE genotypes in Australia: roles in early and late onset Alzheimer's disease and Down's syndrome. Neuroreport. 6: 1513-6. PMID 7579137  0.311
1994 Caporaso GL, Takei K, Gandy SE, Matteoli M, Mundigl O, Greengard P, De Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 3122-38. PMID 8182461  0.352
1994 Jaffe AB, Toran-Allerand CD, Greengard P, Gandy SE. Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein. The Journal of Biological Chemistry. 269: 13065-8. PMID 8175728  0.359
1994 Nordstedt C, Näslund J, Thyberg J, Messamore E, Gandy SE, Terenius L. Human neutrophil phagocytic granules contain a truncated soluble form of the Alzheimer beta/A4 amyloid precursor protein (APP). The Journal of Biological Chemistry. 269: 9805-10. PMID 8144573  0.333
1994 Näslund J, Schierhorn A, Hellman U, Lannfelt L, Roses AD, Tjernberg LO, Silberring J, Gandy SE, Winblad B, Greengard P. Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging. Proceedings of the National Academy of Sciences of the United States of America. 91: 8378-82. PMID 8078890 DOI: 10.1073/Pnas.91.18.8378  0.476
1994 Zhang H, Komano H, Fuller RS, Gandy SE, Frail DE. Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity. The Journal of Biological Chemistry. 269: 27799-802. PMID 7961704  0.329
1994 Gandy S, Greengard P. Processing of Alzheimer A beta-amyloid precursor protein: cell biology, regulation, and role in Alzheimer disease International Review of Neurobiology. 36: 29-50. PMID 7822119 DOI: 10.1016/S0074-7742(08)60302-5  0.585
1994 Gandy S, Greengard P. Regulated cleavage of the Alzheimer amyloid precursor protein: Molecular and cellular basis Biochimie. 76: 300-303. PMID 7819339 DOI: 10.1016/0300-9084(94)90162-7  0.469
1994 Ouimet CC, Baerwald KD, Gandy SE, Greengard P. Immunocytochemical localization of amyloid precursor protein in rat brain. The Journal of Comparative Neurology. 348: 244-60. PMID 7814690 DOI: 10.1002/cne.903480207  0.406
1994 Caporaso G, Takei K, Gandy S, Matteoli M, Mundigl O, Greengard P, De Camilli P. Morphologic and biochemical analysis of the intracellular trafficking of the Alzheimer beta/A4 amyloid precursor protein The Journal of Neuroscience. 14: 3122-3138. DOI: 10.1523/JNEUROSCI.14-05-03122.1994  0.51
1993 Ramabhadran TV, Gandy SE, Ghiso J, Czernik AJ, Ferris D, Bhasin R, Goldgaber D, Frangione B, Greengard P. Proteolytic processing of human amyloid beta protein precursor in insect cells. Major carboxyl-terminal fragment is identical to its human counterpart. The Journal of Biological Chemistry. 268: 2009-12. PMID 8420974  0.347
1993 Nordstedt C, Caporaso GL, Thyberg J, Gandy SE, Greengard P. Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. The Journal of Biological Chemistry. 268: 608-12. PMID 8416966  0.332
1993 Gandy SE, Caporaso GL, Buxbaum JD, de Cruz Silva O, Iverfeldt K, Nordstedt C, Suzuki T, Czernik AJ, Nairn AC, Greengard P. Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. Annals of the New York Academy of Sciences. 695: 117-21. PMID 8239268 DOI: 10.1111/j.1749-6632.1993.tb23038.x  0.468
1992 Suzuki T, Nairn AC, Gandy SE, Greengard P. Phosphorylation of Alzheimer amyloid precursor protein by protein kinase C. Neuroscience. 48: 755-61. PMID 1630623 DOI: 10.1016/0306-4522(92)90264-3  0.45
1992 Gandy S, Greengard P. Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities Trends in Pharmacological Sciences. 13: 108-113. PMID 1574806 DOI: 10.1016/0165-6147(92)90039-9  0.548
1992 Caporaso GL, Gandy SE, Buxbaum JD, Ramabhadran TV, Greengard P. Protein phosphorylation regulates secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 3055-9. PMID 1557413 DOI: 10.1073/PNAS.89.7.3055  0.52
1992 Caporaso GL, Gandy SE, Buxbaum JD, Greengard P. Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 89: 2252-6. PMID 1549591 DOI: 10.1073/PNAS.89.6.2252  0.498
1992 Gandy SE, Buxbaum JD, Suzuki T, Ramabhadran TV, Caporaso GL, Nairn AC, Greengard P. The nature and metabolism of potentially amyloidogenic carboxyl-terminal fragments of the Alzheimer beta/A4-amyloid precursor protein: some technical notes. Neurobiology of Aging. 13: 601-3. PMID 1461349 DOI: 10.1016/0197-4580(92)90063-4  0.483
1992 Gandy SE, Caporaso GL, Ramabhadran TV, Suzuki T, Buxbaum JD, Nordstedt C, Iverfeldt K, Czernik AJ, Nairn AC, Greengard P. Characterization of alternative routes for processing of the Alzheimer beta/A4-amyloid precursor protein. Differential effects of phorbol esters and chloroquine. Annals of the New York Academy of Sciences. 674: 203-17. PMID 1363189 DOI: 10.1111/J.1749-6632.1992.Tb27489.X  0.48
1992 Buxbaum JD, Oishi M, Chen HI, Pinkas-Kramarski R, Jaffe EA, Gandy SE, Greengard P. Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor. Proceedings of the National Academy of Sciences of the United States of America. 89: 10075-8. PMID 1359534 DOI: 10.1073/PNAS.89.21.10075  0.474
1992 Gandy SE, Bhasin R, Ramabhadran TV, Koo EH, Price DL, Goldgaber D, Greengard P. Alzheimer beta/A4-amyloid precursor protein: evidence for putative amyloidogenic fragment. Journal of Neurochemistry. 58: 383-6. PMID 1345769 DOI: 10.1111/J.1471-4159.1992.Tb09322.X  0.472
1991 Nordstedt C, Gandy SE, Alafuzoff I, Caporaso GL, Iverfeldt K, Grebb JA, Winblad B, Greengard P. Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment. Proceedings of the National Academy of Sciences of the United States of America. 88: 8910-4. PMID 1924350 DOI: 10.1073/PNAS.88.20.8910  0.481
1990 Buxbaum JD, Gandy SE, Cicchetti P, Ehrlich ME, Czernik AJ, Fracasso RP, Ramabhadran TV, Unterbeck AJ, Greengard P. Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 87: 6003-6. PMID 2116015 DOI: 10.1073/pnas.87.15.6003  0.46
1988 Gandy S, Czernik AJ, Greengard P. Phosphorylation of Alzheimer disease amyloid precursor peptide by protein kinase C and Ca2+/calmodulin-dependent protein kinase II Proceedings of the National Academy of Sciences of the United States of America. 85: 6218-6221. PMID 3137567 DOI: 10.1073/PNAS.85.16.6218  0.383
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