Aaron D. Gitler - Publications

University of Pennsylvania, Philadelphia, PA, United States 
 Stanford University, Palo Alto, CA 

103 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Fumagalli L, Young FL, Boeynaems S, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, ... ... Gitler AD, et al. -derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility. Science Advances. 7. PMID 33837088 DOI: 10.1126/sciadv.abg3013  0.36
2021 Blum JA, Klemm S, Shadrach JL, Guttenplan KA, Nakayama L, Kathiria A, Hoang PT, Gautier O, Kaltschmidt JA, Greenleaf WJ, Gitler AD. Single-cell transcriptomic analysis of the adult mouse spinal cord reveals molecular diversity of autonomic and skeletal motor neurons. Nature Neuroscience. PMID 33589834 DOI: 10.1038/s41593-020-00795-0  0.6
2020 Kim G, Gautier O, Tassoni-Tsuchida E, Ma XR, Gitler AD. ALS Genetics: Gains, Losses, and Implications for Future Therapies. Neuron. PMID 32931756 DOI: 10.1016/J.Neuron.2020.08.022  0.6
2020 Gautier O, Gitler AD. Neurodegenerative gene's function is not all about those bases. Nature. 585: 34-35. PMID 32814910 DOI: 10.1038/D41586-020-02382-6  0.6
2020 Gitler AD, Shorter J, Ha T, Myong S. Just Took a DNA Test, Turns Out 100% Not That Phase. Molecular Cell. 78: 193-194. PMID 32302539 DOI: 10.1016/J.Molcel.2020.03.029  1
2019 Gittings LM, Boeynaems S, Lightwood D, Clargo A, Topia S, Nakayama L, Troakes C, Mann DMA, Gitler AD, Lashley T, Isaacs AM. Symmetric dimethylation of poly-GR correlates with disease duration in C9orf72 FTLD and ALS and reduces poly-GR phase separation and toxicity. Acta Neuropathologica. PMID 31832771 DOI: 10.1007/S00401-019-02104-X  0.36
2019 Boeynaems S, Gitler AD. Axons Gonna Ride 'til They Can't No More. Neuron. 104: 179-181. PMID 31647889 DOI: 10.1016/J.Neuron.2019.09.029  0.36
2019 Boeynaems S, Holehouse AS, Weinhardt V, Kovacs D, Van Lindt J, Larabell C, Van Den Bosch L, Das R, Tompa PS, Pappu RV, Gitler AD. Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties. Proceedings of the National Academy of Sciences of the United States of America. PMID 30926670 DOI: 10.1073/Pnas.1821038116  0.36
2018 Boeynaems S, Gitler AD. Pour Some Sugar on TDP(-43). Molecular Cell. 71: 649-651. PMID 30193092 DOI: 10.1016/J.Molcel.2018.08.032  0.36
2018 Boeynaems S, Gitler AD. Phosphorylation Leads the Way for Protein Aggregate Disassembly. Developmental Cell. 45: 279-281. PMID 29738705 DOI: 10.1016/J.Devcel.2018.04.017  0.36
2018 Guo L, Kim HJ, Wang H, Monaghan J, Freyermuth F, Sung JC, O'Donovan K, Fare CM, Diaz Z, Singh N, Zhang ZC, Coughlin M, Sweeny EA, DeSantis ME, Jackrel ME, ... ... Gitler AD, et al. Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains. Cell. 173: 677-692.e20. PMID 29677512 DOI: 10.1016/J.Cell.2018.03.002  1
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Gitler AD, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.36
2018 Kramer NJ, Haney MS, Morgens DW, Jovičić A, Couthouis J, Li A, Ousey J, Ma R, Bieri G, Tsui CK, Shi Y, Hertz NT, Tessier-Lavigne M, Ichida JK, Bassik MC, ... Gitler AD, et al. CRISPR-Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity. Nature Genetics. PMID 29507424 DOI: 10.1038/S41588-018-0070-7  0.56
2017 Gitler AD, Dhillon P, Shorter J. Neurodegenerative disease: models, mechanisms, and a new hope. Disease Models & Mechanisms. 10: 499-502. PMID 28468935 DOI: 10.1242/Dmm.030205  1
2017 Becker LA, Huang B, Bieri G, Ma R, Knowles DA, Jafar-Nejad P, Messing J, Kim HJ, Soriano A, Auburger G, Pulst SM, Taylor JP, Rigo F, Gitler AD. Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice. Nature. PMID 28405022 DOI: 10.1038/Nature22038  0.36
2017 Gitler AD, Jarosz DF. Old moms say, no Sir. Science (New York, N.Y.). 355: 1126-1127. PMID 28302810 DOI: 10.1126/Science.Aam9740  0.92
2017 Jovičić A, Gitler AD. Distinct repertoires of microRNAs present in mouse astrocytes compared to astrocyte-secreted exosomes. Plos One. 12: e0171418. PMID 28152040 DOI: 10.1371/Journal.Pone.0171418  0.56
2016 Shorter J, Gitler AD. Susan Lee Lindquist (1949-2016). Nature. 540: 40. PMID 27905439 DOI: 10.1038/540040A  1
2016 Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, ... ... Gitler AD, et al. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science (New York, N.Y.). 353: 708-12. PMID 27516603 DOI: 10.1126/Science.Aaf7791  1
2016 Dikiy I, Fauvet B, Jovičić A, Mahul-Mellier AL, Desobry C, El-Turk F, Gitler AD, Lashuel HA, Eliezer D. Semisynthetic and in vitro phosphorylation of alpha-synuclein at Y39 promotes functional partly-helical membrane-bound states resembling those induced by PD mutations. Acs Chemical Biology. PMID 27356045 DOI: 10.1021/Acschembio.6B00539  1
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/J.Neuron.2016.05.021  1
2016 Jovičić A, Paul JW, Gitler AD. Nuclear transport dysfunction: a common theme in amyotrophic lateral sclerosis and frontotemporal dementia. Journal of Neurochemistry. PMID 27087014 DOI: 10.1111/Jnc.13642  0.56
2016 Williams KL, Topp S, Yang S, Smith B, Fifita JA, Warraich ST, Zhang KY, Farrawell N, Vance C, Hu X, Chesi A, Leblond CS, Lee A, Rayner SL, Sundaramoorthy V, ... ... Gitler AD, et al. CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia. Nature Communications. 7: 11253. PMID 27080313 DOI: 10.1038/Ncomms11253  1
2016 Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, ... ... Gitler AD, et al. Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD. Scientific Reports. 6: 20877. PMID 26869068 DOI: 10.1038/Srep20877  1
2016 Brahic M, Bousset L, Bieri G, Melki R, Gitler AD. Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1. Acta Neuropathologica. PMID 26820848 DOI: 10.1007/S00401-016-1538-0  1
2015 Margulis NG, Wilson JD, Bentivoglio CM, Dhungel N, Gitler AD, Barlowe C. Analysis of COPII vesicles indicates a role for the Emp47-Ssp120 complex in transport of cell surface glycoproteins. Traffic (Copenhagen, Denmark). PMID 26650540 DOI: 10.1111/Tra.12356  1
2015 Coyne AN, Yamada SB, Siddegowda BB, Estes PS, Zaepfel BL, Johannesmeyer JS, Lockwood DB, Pham LT, Hart MP, Cassel JA, Freibaum B, Boehringer AV, Taylor JP, Reitz AB, Gitler AD, et al. Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation. Human Molecular Genetics. PMID 26385636 DOI: 10.1093/Hmg/Ddv389  1
2015 Jovičić A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nature Neuroscience. 18: 1226-9. PMID 26308983 DOI: 10.1038/Nn.4085  0.56
2015 Figley MD, Gitler AD. Neurodegeneration: A Leg Up on TDP-43. Current Biology : Cb. 25: R728-31. PMID 26294190 DOI: 10.1016/J.Cub.2015.06.064  1
2015 Becker LA, Gitler AD. It's all starting to come together. Elife. 4. PMID 26244628 DOI: 10.7554/Elife.09853  1
2015 Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, Leblond CS, Couthouis J, Lu YF, Wang Q, Krueger BJ, Ren Z, Keebler J, Han Y, Levy SE, Boone BE, ... ... Gitler AD, et al. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science (New York, N.Y.). 347: 1436-41. PMID 25700176 DOI: 10.1126/Science.Aaa3650  1
2015 Dhungel N, Eleuteri S, Li LB, Kramer NJ, Chartron JW, Spencer B, Kosberg K, Fields JA, Stafa K, Adame A, Lashuel H, Frydman J, Shen K, Masliah E, Gitler AD. Parkinson's disease genes VPS35 and EIF4G1 interact genetically and converge on α-synuclein. Neuron. 85: 76-87. PMID 25533483 DOI: 10.1016/J.Neuron.2014.11.027  1
2015 Jovičič A, Mertens J, Boeynaems S, Bogaert E, Chai N, Yamada SB, Paul JW, Sun S, Herdy JR, Bieri G, Kramer NJ, Gage FH, Van Den Bosch L, Robberecht W, Gitler AD. Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS Nature Neuroscience. 18: 1226-1229. DOI: 10.1038/nn.4085  1
2014 Couthouis J, Raphael AR, Daneshjou R, Gitler AD. Targeted exon capture and sequencing in sporadic amyotrophic lateral sclerosis. Plos Genetics. 10: e1004704. PMID 25299611 DOI: 10.1371/Journal.Pgen.1004704  1
2014 Paul JW, West JP, Gitler AD. Cell Biology. Clogging information flow in ALS. Science (New York, N.Y.). 345: 1118-9. PMID 25190778 DOI: 10.1126/Science.1259461  1
2014 Figley MD, Bieri G, Kolaitis RM, Taylor JP, Gitler AD. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8083-97. PMID 24920614 DOI: 10.1523/JNEUROSCI.0543-14.2014  1
2014 Guo L, Giasson BI, Glavis-Bloom A, Brewer MD, Shorter J, Gitler AD, Yang X. A cellular system that degrades misfolded proteins and protects against neurodegeneration. Molecular Cell. 55: 15-30. PMID 24882209 DOI: 10.1016/J.Molcel.2014.04.030  1
2014 Raphael AR, Couthouis J, Sakamuri S, Siskind C, Vogel H, Day JW, Gitler AD. Congenital muscular dystrophy and generalized epilepsy caused by GMPPB mutations. Brain Research. 1575: 66-71. PMID 24780531 DOI: 10.1016/J.Brainres.2014.04.028  1
2014 Fares MB, Ait-Bouziad N, Dikiy I, Mbefo MK, Jovičić A, Kiely A, Holton JL, Lee SJ, Gitler AD, Eliezer D, Lashuel HA. The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear localization in cells. Human Molecular Genetics. 23: 4491-509. PMID 24728187 DOI: 10.1093/Hmg/Ddu165  1
2014 Akimoto C, Volk AE, van Blitterswijk M, Van den Broeck M, Leblond CS, Lumbroso S, Camu W, Neitzel B, Onodera O, van Rheenen W, Pinto S, Weber M, Smith B, Proven M, Talbot K, ... ... Gitler AD, et al. A blinded international study on the reliability of genetic testing for GGGGCC-repeat expansions in C9orf72 reveals marked differences in results among 14 laboratories. Journal of Medical Genetics. 51: 419-24. PMID 24706941 DOI: 10.1136/Jmedgenet-2014-102360  1
2014 Couthouis J, Raphael AR, Siskind C, Findlay AR, Buenrostro JD, Greenleaf WJ, Vogel H, Day JW, Flanigan KM, Gitler AD. Exome sequencing identifies a DNAJB6 mutation in a family with dominantly-inherited limb-girdle muscular dystrophy. Neuromuscular Disorders : Nmd. 24: 431-5. PMID 24594375 DOI: 10.1016/J.Nmd.2014.01.014  1
2014 Jovičić A, Gitler AD. TDP-43 in ALS: stay on target…almost there. Neuron. 81: 463-5. PMID 24507183 DOI: 10.1016/J.Neuron.2014.01.034  1
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/Ng.2853  1
2014 Figley MD, Thomas A, Gitler AD. Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 35: 936.e1-4. PMID 24269018 DOI: 10.1016/J.Neurobiolaging.2013.09.024  1
2013 Figley MD, Gitler AD. Yeast genetic screen reveals novel therapeutic strategy for ALS. Rare Diseases (Austin, Tex.). 1: e24420. PMID 25002991 DOI: 10.4161/rdis.24420  1
2013 Aguzzi A, Gitler AD. A template for new drugs against Alzheimer's disease. Cell. 154: 1182-4. PMID 24034239 DOI: 10.1016/J.Cell.2013.08.049  1
2013 Staahl BT, Tang J, Wu W, Sun A, Gitler AD, Yoo AS, Crabtree GR. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10348-61. PMID 23785148 DOI: 10.1523/Jneurosci.1258-13.2013  1
2013 Chesi A, Staahl BT, Jovičić A, Couthouis J, Fasolino M, Raphael AR, Yamazaki T, Elias L, Polak M, Kelly C, Williams KL, Fifita JA, Maragakis NJ, Nicholson GA, King OD, ... ... Gitler AD, et al. Exome sequencing to identify de novo mutations in sporadic ALS trios. Nature Neuroscience. 16: 851-5. PMID 23708140 DOI: 10.1038/Nn.3412  1
2013 Li YR, King OD, Shorter J, Gitler AD. Stress granules as crucibles of ALS pathogenesis. The Journal of Cell Biology. 201: 361-72. PMID 23629963 DOI: 10.1083/Jcb.201302044  1
2013 Kim HJ, Kim NC, Wang YD, Scarborough EA, Moore J, Diaz Z, MacLea KS, Freibaum B, Li S, Molliex A, Kanagaraj AP, Carter R, Boylan KB, Wojtas AM, Rademakers R, ... ... Gitler AD, et al. Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS. Nature. 495: 467-73. PMID 23455423 DOI: 10.1038/Nature11922  1
2013 Chuang RS, Gitler AD. Parallel PARKing: Parkinson's genes function in common pathway. Neuron. 77: 377-9. PMID 23395366 DOI: 10.1016/J.Neuron.2013.01.014  1
2012 Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics. 44: 1302-9. PMID 23104007 DOI: 10.1038/Ng.2434  1
2012 Gitler AD. TDP-43 and FUS/TLS yield a target-rich haul in ALS. Nature Neuroscience. 15: 1467-9. PMID 23103989 DOI: 10.1038/Nn.3243  1
2012 Weisberg SJ, Lyakhovetsky R, Werdiger AC, Gitler AD, Soen Y, Kaganovich D. Compartmentalization of superoxide dismutase 1 (SOD1G93A) aggregates determines their toxicity. Proceedings of the National Academy of Sciences of the United States of America. 109: 15811-6. PMID 22967507 DOI: 10.1073/Pnas.1205829109  1
2012 Gitler AD, Lehmann R. Modeling human disease. Science (New York, N.Y.). 337: 269. PMID 22822114 DOI: 10.1126/Science.1227179  1
2012 Hart MP, Gitler AD. ALS-associated ataxin 2 polyQ expansions enhance stress-induced caspase 3 activation and increase TDP-43 pathological modifications. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 9133-42. PMID 22764223 DOI: 10.1523/Jneurosci.0996-12.2012  1
2012 Hart MP, Brettschneider J, Lee VM, Trojanowski JQ, Gitler AD. Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions. Acta Neuropathologica. 124: 221-30. PMID 22526021 DOI: 10.1007/S00401-012-0985-5  1
2012 Chesi A, Kilaru A, Fang X, Cooper AA, Gitler AD. The role of the Parkinson's disease gene PARK9 in essential cellular pathways and the manganese homeostasis network in yeast. Plos One. 7: e34178. PMID 22457822 DOI: 10.1371/Journal.Pone.0034178  1
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Gitler AD, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/Hmg/Dds116  1
2012 King OD, Gitler AD, Shorter J. The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Research. 1462: 61-80. PMID 22445064 DOI: 10.1016/J.Brainres.2012.01.016  1
2012 Gispert S, Kurz A, Waibel S, Bauer P, Liepelt I, Geisen C, Gitler AD, Becker T, Weber M, Berg D, Andersen PM, Krüger R, Riess O, Ludolph AC, Auburger G. The modulation of Amyotrophic Lateral Sclerosis risk by ataxin-2 intermediate polyglutamine expansions is a specific effect. Neurobiology of Disease. 45: 356-61. PMID 21889984 DOI: 10.1016/J.Nbd.2011.08.021  1
2011 Liu-Yesucevitz L, Bassell GJ, Gitler AD, Hart AC, Klann E, Richter JD, Warren ST, Wolozin B. Local RNA translation at the synapse and in disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16086-93. PMID 22072660 DOI: 10.1523/Jneurosci.4105-11.2011  1
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, ... ... Gitler AD, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/Pnas.1109434108  1
2011 Gitler AD. Neuroscience. Another reason to exercise. Science (New York, N.Y.). 334: 606-7. PMID 22053033 DOI: 10.1126/Science.1214714  1
2011 Gitler AD, Shorter J. RNA-binding proteins with prion-like domains in ALS and FTLD-U. Prion. 5: 179-87. PMID 21847013 DOI: 10.4161/Pri.5.3.17230  1
2011 Fleming MS, Gitler AD. High-throughput yeast plasmid overexpression screen. Journal of Visualized Experiments : Jove. PMID 21841759 DOI: 10.3791/2836  1
2011 Bonini NM, Gitler AD. Model organisms reveal insight into human neurodegenerative disease: ataxin-2 intermediate-length polyglutamine expansions are a risk factor for ALS. Journal of Molecular Neuroscience : Mn. 45: 676-83. PMID 21660502 DOI: 10.1007/S12031-011-9548-9  1
2011 Lee T, Li YR, Chesi A, Hart MP, Ramos D, Jethava N, Hosangadi D, Epstein J, Hodges B, Bonini NM, Gitler AD. Evaluating the prevalence of polyglutamine repeat expansions in amyotrophic lateral sclerosis. Neurology. 76: 2062-5. PMID 21562248 DOI: 10.1212/Wnl.0B013E31821F4447  1
2011 Sun Z, Diaz Z, Fang X, Hart MP, Chesi A, Shorter J, Gitler AD. Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS. Plos Biology. 9: e1000614. PMID 21541367 DOI: 10.1371/Journal.Pbio.1000614  1
2011 Konopka CA, Locke MN, Gallagher PS, Pham N, Hart MP, Walker CJ, Gitler AD, Gardner RG. A yeast model for polyalanine-expansion aggregation and toxicity. Molecular Biology of the Cell. 22: 1971-84. PMID 21508314 DOI: 10.1091/Mbc.E11-01-0037  1
2011 Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. Plos One. 6: e17951. PMID 21479228 DOI: 10.1371/Journal.Pone.0017951  1
2011 Lee T, Li YR, Ingre C, Weber M, Grehl T, Gredal O, de Carvalho M, Meyer T, Tysnes OB, Auburger G, Gispert S, Bonini NM, Andersen PM, Gitler AD. Ataxin-2 intermediate-length polyglutamine expansions in European ALS patients. Human Molecular Genetics. 20: 1697-700. PMID 21292779 DOI: 10.1093/Hmg/Ddr045  1
2011 Armakola M, Hart MP, Gitler AD. TDP-43 toxicity in yeast. Methods (San Diego, Calif.). 53: 238-45. PMID 21115123 DOI: 10.1016/J.Ymeth.2010.11.006  1
2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, ... ... Gitler AD, et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 466: 1069-75. PMID 20740007 DOI: 10.1038/Nature09320  1
2010 Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ. GTPase activity plays a key role in the pathobiology of LRRK2. Plos Genetics. 6: e1000902. PMID 20386743 DOI: 10.1371/Journal.Pgen.1000902  1
2010 Cushman M, Johnson BS, King OD, Gitler AD, Shorter J. Prion-like disorders: blurring the divide between transmissibility and infectivity. Journal of Cell Science. 123: 1191-201. PMID 20356930 DOI: 10.1242/Jcs.051672  1
2009 Johnson BS, Snead D, Lee JJ, McCaffery JM, Shorter J, Gitler AD. TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. The Journal of Biological Chemistry. 284: 20329-39. PMID 19465477 DOI: 10.1074/Jbc.M109.010264  1
2009 Gitler AD. Disease models and mechanisms in the classroom. Disease Models & Mechanisms. 2: 103-6. PMID 19259378 DOI: 10.1242/Dmm.002600  1
2009 Yeger-Lotem E, Riva L, Su LJ, Gitler AD, Cashikar AG, King OD, Auluck PK, Geddie ML, Valastyan JS, Karger DR, Lindquist S, Fraenkel E. Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nature Genetics. 41: 316-23. PMID 19234470 DOI: 10.1038/Ng.337  1
2009 Gitler AD, Chesi A, Geddie ML, Strathearn KE, Hamamichi S, Hill KJ, Caldwell KA, Caldwell GA, Cooper AA, Rochet JC, Lindquist S. Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nature Genetics. 41: 308-15. PMID 19182805 DOI: 10.1038/Ng.300  1
2009 Rappley I, Gitler AD, Selvy PE, LaVoie MJ, Levy BD, Brown HA, Lindquist S, Selkoe DJ. Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry. 48: 1077-83. PMID 19146388 DOI: 10.1021/Bi801871H  1
2008 Sun Z, Gitler AD. Discovery and characterization of three novel synuclein genes in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 2490-5. PMID 18521955 DOI: 10.1002/Dvdy.21569  1
2008 Johnson BS, McCaffery JM, Lindquist S, Gitler AD. A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 105: 6439-44. PMID 18434538 DOI: 10.1073/Pnas.0802082105  1
2008 Gitler AD, Bevis BJ, Shorter J, Strathearn KE, Hamamichi S, Su LJ, Caldwell KA, Caldwell GA, Rochet JC, McCaffery JM, Barlowe C, Lindquist S. The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 105: 145-50. PMID 18162536 DOI: 10.1073/Pnas.0710685105  1
2008 Gitler AD. Beer and bread to brains and beyond: can yeast cells teach us about neurodegenerative disease? Neuro-Signals. 16: 52-62. PMID 18097160 DOI: 10.1159/000109759  1
2007 Alberti S, Gitler AD, Lindquist S. A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (Chichester, England). 24: 913-9. PMID 17583893 DOI: 10.1002/Yea.1502  1
2007 Gitler AD, Shorter J. Prime time for alpha-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2433-4. PMID 17344380 DOI: 10.1523/Jneurosci.0094-07.2007  1
2006 Wu J, O'Donnell M, Gitler AD, Klein PS. Kermit 2/XGIPC, an IGF1 receptor interacting protein, is required for IGF signaling in Xenopus eye development. Development (Cambridge, England). 133: 3651-60. PMID 16914488 DOI: 10.1242/Dev.02547  1
2006 Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, et al. Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (New York, N.Y.). 313: 324-8. PMID 16794039 DOI: 10.1126/Science.1129462  1
2005 Engleka KA, Gitler AD, Zhang M, Zhou DD, High FA, Epstein JA. Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Developmental Biology. 280: 396-406. PMID 15882581 DOI: 10.1016/J.Ydbio.2005.02.002  1
2005 Lindquist S, Fraenkel E, Outeiro T, Gitler A, Su J, Cashikar A, Jagadish S. Yeast cells as a discovery platform for neurodegenerative disease Lecture Notes in Bioinformatics (Subseries of Lecture Notes in Computer Science). 3500: 102.  1
2004 Torres-Vázquez J, Gitler AD, Fraser SD, Berk JD, Van N Pham, Fishman MC, Childs S, Epstein JA, Weinstein BM. Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7: 117-23. PMID 15239959 DOI: 10.1016/J.Devcel.2004.06.008  1
2004 Gitler AD, Lu MM, Epstein JA. PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Developmental Cell. 7: 107-16. PMID 15239958 DOI: 10.1016/J.Devcel.2004.06.002  1
2004 Gitler AD, Kong Y, Choi JK, Zhu Y, Pear WS, Epstein JA. Tie2-Cre-induced inactivation of a conditional mutant Nf1 allele in mouse results in a myeloproliferative disorder that models juvenile myelomonocytic leukemia. Pediatric Research. 55: 581-4. PMID 14739366 DOI: 10.1203/01.Pdr.0000113462.98851.2E  1
2003 Gitler AD, Lu MM, Jiang YQ, Epstein JA, Gruber PJ. Molecular markers of cardiac endocardial cushion development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 228: 643-50. PMID 14648841 DOI: 10.1002/Dvdy.10418  1
2003 Kook H, Lepore JJ, Gitler AD, Lu MM, Wing-Man Yung W, Mackay J, Zhou R, Ferrari V, Gruber P, Epstein JA. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. The Journal of Clinical Investigation. 112: 863-71. PMID 12975471 DOI: 10.1172/Jci19137  1
2003 Kochilas LK, Potluri V, Gitler A, Balasubramanian K, Chin AJ. Cloning and characterization of zebrafish tbx1. Gene Expression Patterns : Gep. 3: 645-51. PMID 12972000 DOI: 10.1016/S1567-133X(03)00108-X  1
2003 Gitler AD, Epstein JA. Regulating heart development: the role of Nf1. Cell Cycle (Georgetown, Tex.). 2: 96-8. PMID 12695655 DOI: 10.4161/Cc.2.2.299  1
2003 Gitler AD, Zhu Y, Ismat FA, Lu MM, Yamauchi Y, Parada LF, Epstein JA. Nf1 has an essential role in endothelial cells. Nature Genetics. 33: 75-9. PMID 12469121 DOI: 10.1038/Ng1059  1
2002 Gitler AD, Brown CB, Kochilas L, Li J, Epstein JA. Neural crest migration and mouse models of congenital heart disease. Cold Spring Harbor Symposia On Quantitative Biology. 67: 57-62. PMID 12858524 DOI: 10.1101/Sqb.2002.67.57  1
2002 Chen F, Kook H, Milewski R, Gitler AD, Lu MM, Li J, Nazarian R, Schnepp R, Jen K, Biben C, Runke G, Mackay JP, Novotny J, Schwartz RJ, Harvey RP, et al. Hop is an unusual homeobox gene that modulates cardiac development. Cell. 110: 713-23. PMID 12297045 DOI: 10.1016/S0092-8674(02)00932-7  1
2000 Lu MM, Chen F, Gitler A, Li J, Jin F, Ma XK, Epstein JA. Cloning and expression analysis of murine lupin, a member of a novel gene family that is conserved through evolution and associated with Lupus inclusions Development Genes and Evolution. 210: 512-517. PMID 11180800 DOI: 10.1007/S004270000093  1
1999 Gunatilaka AA, Paul VJ, Park PU, Puglisi MP, Gitler AD, Eggleston DS, Haltiwanger RC, Kingston DG. Apakaochtodenes A and B: two tetrahalogenated monoterpenes from the red marine alga Portieria hornemannii. Journal of Natural Products. 62: 1376-8. PMID 10543896 DOI: 10.1021/Np9901128  1
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