Surendra S. Ambegaokar, PhD - Related publications

Affiliations: 
Neuroscience and Cell Biology University of Texas Medical Branch, Galveston, TX 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Narayanan SE, Sekhar N, Rajamma RG, Marathakam A, Al Mamun A, Uddin MS, Mathew B. Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Current Protein & Peptide Science. PMID 32957903 DOI: 10.2174/1389203721666200921152246   
2020 Ray WJ, Buggia-Prevot V. Novel Targets for Alzheimer's Disease: A View Beyond Amyloid. Annual Review of Medicine. PMID 32867590 DOI: 10.1146/annurev-med-052919-120219   
2020 Muralidar S, Ambi SV, Sekaran S, Thirumalai D, Palaniappan B. Role of tau protein in Alzheimer's disease: The prime pathological player. International Journal of Biological Macromolecules. PMID 32784025 DOI: 10.1016/j.ijbiomac.2020.07.327   
2020 De La-Rocque S, Moretto E, Butnaru I, Schiavo G. Knockin' on heaven's door: Molecular mechanisms of neuronal tau uptake. Journal of Neurochemistry. PMID 32770783 DOI: 10.1111/jnc.15144   
2020 Yeung CHC, Lau KWD, Au Yeung SL, Schooling CM. Amyloid, tau and risk of Alzheimer's disease: a Mendelian randomization study. European Journal of Epidemiology. PMID 32929646 DOI: 10.1007/s10654-020-00683-8   
2020 Liu M, Sui D, Dexheimer T, Hovde S, Deng X, Wang KW, Lin HL, Chien HT, Kweon HK, Kuo NS, Ayoub CA, Jimenez-Harrison D, Andrews PC, Kwok R, Bochar DA, et al. Hyperphosphorylation Renders Tau Prone to Aggregate and to Cause Cell Death. Mol Neurobiol. PMID 32780352 DOI: 10.1007/s12035-020-02034-w   
2020 Gao J, Chen X, Ma T, He B, Li P, Zhao Y, Ma Y, Zhuang J, Yin Y. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. International Journal of Nanomedicine. 15: 6779-6789. PMID 32982233 DOI: 10.2147/IJN.S258311   
2020 Horie K, Barthélemy NR, Mallipeddi N, Li Y, Franklin EE, Perrin RJ, Bateman RJ, Sato C. Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain. Acta Neuropathologica Communications. 8: 149. PMID 32854776 DOI: 10.1186/s40478-020-01019-z   
2020 d'Abramo C, D'Adamio L, Giliberto L. Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use. Journal of Personalized Medicine. 10. PMID 32911755 DOI: 10.3390/jpm10030116   
2020 Kang SS, Ahn EH, Ye K. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease. Experimental & Molecular Medicine. PMID 32859953 DOI: 10.1038/s12276-020-00494-7   
2020 Guha S, Johnson GVW, Nehrke K. The Crosstalk Between Pathological Tau Phosphorylation and Mitochondrial Dysfunction as a Key to Understanding and Treating Alzheimer's Disease. Molecular Neurobiology. PMID 32851560 DOI: 10.1007/s12035-020-02084-0   
2020 Triana-Baltzer G, Van Kolen K, Theunis C, Moughadam S, Slemmon R, Mercken M, Galpern W, Sun H, Kolb H. Development and Validation of a High Sensitivity Assay for Measuring p217 + tau in Cerebrospinal Fluid. Journal of Alzheimer's Disease : Jad. PMID 32831201 DOI: 10.3233/JAD-200463   
2020 Sopko R, Golonzhka O, Arndt J, Quan C, Czerkowicz J, Cameron A, Smith B, Murugesan Y, Gibbons G, Kim SJ, Trojanowski JQ, Lee VMY, Brunden KR, Weinreb PH, Graham DL, et al. Characterization of tau binding by gosuranemab. Neurobiology of Disease. 105120. PMID 32991997 DOI: 10.1016/j.nbd.2020.105120   
2020 Lo Cascio F, Garcia S, Montalbano M, Puangmalai N, McAllen S, Pace A, Palumbo Piccionello A, Kayed R. Modulating Disease-Relevant Tau Oligomeric Strains by Small Molecules. The Journal of Biological Chemistry. PMID 32737202 DOI: 10.1074/jbc.RA120.014630   
2020 Houben S, de Fisenne MA, Ando K, Vanden Dries V, Poncelet L, Yilmaz Z, Mansour S, De Decker R, Brion JP, Leroy K. Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. Frontiers in Molecular Neuroscience. 13: 106. PMID 32765217 DOI: 10.3389/fnmol.2020.00106   
2020 Yan Y, Yan H, Teng Y, Wang Q, Yang P, Zhang L, Cheng H, Fu S. Long noncoding RNA 00507/miRNA-181c-5p/TTBK1/MAPT axis regulates tau hyperphosphorylation in Alzheimer's disease. The Journal of Gene Medicine. e3268. PMID 32891070 DOI: 10.1002/jgm.3268   
2020 Siano G, Varisco M, Scarlatti A, Caiazza MC, Dunville K, Cremisi F, Costa M, Pancrazi L, Di Primio C, Cattaneo A. Gene expression of disease-related genes in Alzheimer's disease is impaired by Tau aggregation. Journal of Molecular Biology. PMID 33058882 DOI: 10.1016/j.jmb.2020.10.009   
2020 Zhang W, Bai S, Yang J, Zhang Y, Liu Y, Nie J, Meng D, Shi R, Yao Z, Wang M, Wang H, Li C. FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro. Neuroscience Letters. 135322. PMID 32860886 DOI: 10.1016/j.neulet.2020.135322   
2020 Anu K R, Das S, Joseph A, Shenoy GG, Alex AT, Mudgal J. Neurodegenerative Pathways in Alzheimer's Disease: A Review. Current Neuropharmacology. PMID 32851951 DOI: 10.2174/1570159X18666200807130637   
2020 Weitzman SA, Narasimhan S, He Z, Changolkar L, McBride JD, Zhang B, Schellenberg GD, Trojanowski JQ, Lee VMY. Insoluble Tau From Human FTDP-17 Cases Exhibit Unique Transmission Properties In Vivo. Journal of Neuropathology and Experimental Neurology. 79: 941-949. PMID 32838419 DOI: 10.1093/jnen/nlaa086   
2020 Liu M, Dexheimer T, Sui D, Hovde S, Deng X, Kwok R, Bochar DA, Kuo MH. Hyperphosphorylated tau aggregation and cytotoxicity modulators screen identified prescription drugs linked to Alzheimer's disease and cognitive functions. Scientific Reports. 10: 16551. PMID 33024171 DOI: 10.1038/s41598-020-73680-2   
2020 Race B, Williams K, Striebel JF, Chesebro B. Prion-associated cerebral amyloid angiopathy is not exacerbated by human phosphorylated tau aggregates in scrapie-infected mice expressing anchorless prion protein. Neurobiology of Disease. 144: 105057. PMID 32829029 DOI: 10.1016/j.nbd.2020.105057   
2020 Montalbano M, McAllen S, Puangmalai N, Sengupta U, Bhatt N, Johnson OD, Kharas MG, Kayed R. RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature Communications. 11: 4305. PMID 32855391 DOI: 10.1038/s41467-020-18022-6   
2020 Saddiki H, Fayosse A, Cognat E, Sabia S, Engelborghs S, Wallon D, Alexopoulos P, Blennow K, Zetterberg H, Parnetti L, Zerr I, Hermann P, Gabelle A, Boada M, Orellana A, ... , et al. Age and the association between apolipoprotein E genotype and Alzheimer disease: A cerebrospinal fluid biomarker-based case-control study. Plos Medicine. 17: e1003289. PMID 32817639 DOI: 10.1371/journal.pmed.1003289   
2020 Darwich NF, Phan JM, Kim B, Suh E, Papatriantafyllou JD, Changolkar L, Nguyen AT, O'Rourke CM, He Z, Porta S, Gibbons GS, Luk KC, Papageorgiou SG, Grossman M, Massimo L, et al. Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau. Science (New York, N.Y.). PMID 33004675 DOI: 10.1126/science.aay8826   
2020 Henríquez G, Gomez A, Guerrero ED, Narayan M. The Potential Role of Natural Polyphenols Against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical studies. Acs Chemical Neuroscience. PMID 32822152 DOI: 10.1021/acschemneuro.0c00381   
2020 Mold MJ, O'Farrell A, Morris B, Exley C. Aluminum and Neurofibrillary Tangle Co-Localization in Familial Alzheimer's Disease and Related Neurological Disorders. Journal of Alzheimer's Disease : Jad. PMID 32925074 DOI: 10.3233/JAD-200838   
2020 Baker JD, Uhrich RL, Strovas TJ, Saxton AD, Kraemer BC. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery. Slas Discovery : Advancing Life Sciences R & D. 2472555220958387. PMID 32981422 DOI: 10.1177/2472555220958387   
2020 Beauchamp LC, Liu XM, Sedjahtera A, Bogeski M, Vella LJ, Bush AI, Adlard PA, Barnham KJ. S-Adenosylmethionine Rescues Cognitive Deficits in the rTg4510 Animal Model by Stabilizing Protein Phosphatase 2A and Reducing Phosphorylated Tau. Journal of Alzheimer's Disease : Jad. PMID 32925070 DOI: 10.3233/JAD-200756   
2020 Corsetti V, Borreca A, Latina V, Giacovazzo G, Pignataro A, Krashia P, Natale F, Cocco S, Rinaudo M, Malerba F, Florio R, Ciarapica R, Coccurello R, D'Amelio M, Ammassari-Teule M, et al. Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models. Brain Communications. 2: fcaa039. PMID 32954296 DOI: 10.1093/braincomms/fcaa039   
2020 Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32975365 DOI: 10.1002/alz.12185   
2020 Mangleburg CG, Wu T, Yalamanchili HK, Guo C, Hsieh YC, Duong DM, Dammer EB, De Jager PL, Seyfried NT, Liu Z, Shulman JM. Integrated analysis of the aging brain transcriptome and proteome in tauopathy. Molecular Neurodegeneration. 15: 56. PMID 32993812 DOI: 10.1186/s13024-020-00405-4   
2020 Goedert M. Tau proteinopathies and the prion concept. Progress in Molecular Biology and Translational Science. 175: 239-259. PMID 32958235 DOI: 10.1016/bs.pmbts.2020.08.003   
2020 Van Kolen K, Malia TJ, Theunis C, Nanjunda R, Teplyakov A, Ernst R, Wu SJ, Luo J, Borgers M, Vandermeeren M, Bottelbergs A, Wintmolders C, Lacy E, Maurin H, Larsen P, et al. Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. Journal of Alzheimer's Disease : Jad. PMID 32894244 DOI: 10.3233/JAD-200544   
2020 Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32962164 DOI: 10.3390/ijms21186867   
2020 Mishra J, Kumar B, Pandey M, Pottoo FH, Fayaz F, Khan FA, Sahoo PK. Carbon Nano Tubes: Novel drug delivery system in amelioration of Alzheimer's disease. Combinatorial Chemistry & High Throughput Screening. PMID 32957874 DOI: 10.2174/1386207323999200918112538   
2020 Arnsten AFT, Datta D, Tredici KD, Braak H. Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33075193 DOI: 10.1002/alz.12192   
2020 Ukmar-Godec T, Fang P, Ibáñez de Opakua A, Henneberg F, Godec A, Pan KT, Cima-Omori MS, Chari A, Mandelkow E, Urlaub H, Zweckstetter M. Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution. Science Advances. 6: eaba3916. PMID 32832664 DOI: 10.1126/sciadv.aba3916   
2020 Park KHJ, Barrett T. Gliosis Precedes Amyloid-β Deposition and Pathological Tau Accumulation in the Neuronal Cell Cycle Re-Entry Mouse Model of Alzheimer's Disease. Journal of Alzheimer's Disease Reports. 4: 243-253. PMID 32904753 DOI: 10.3233/ADR-200170   
2020 von Saucken VE, Jay TR, Landreth GE. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of Disease. 105072. PMID 32890775 DOI: 10.1016/j.nbd.2020.105072   
2020 Ojaghi S, Mohammadi S, Amani M, Ghobadi S, Bijari N, Esmaeili S, Khodarahmi R. Sunset yellow degradation product, as an efficient water-soluble inducer, accelerates 1N4R Tau amyloid oligomerization: In vitro preliminary evidence against the food colorant safety in terms of "Triggered Amyloid Aggregation". Bioorganic Chemistry. 103: 104123. PMID 32781343 DOI: 10.1016/j.bioorg.2020.104123   
2020 Shen XN, Li JQ, Wang HF, Li HQ, Huang YY, Yang YX, Tan L, Dong Q, Yu JT, . Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12104. PMID 33005724 DOI: 10.1002/dad2.12104   
2020 Shen XN, Li JQ, Wang HF, Li HQ, Huang YY, Yang YX, Tan L, Dong Q, Yu JT, . Plasma amyloid, tau, and neurodegeneration biomarker profiles predict Alzheimer's disease pathology and clinical progression in older adults without dementia. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12104. PMID 33005724 DOI: 10.1002/dad2.12104   
2020 Qu X, Guan P, Han L, Wang Z, Huang X. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33034847 DOI: 10.1007/s13311-020-00943-1   
2020 Pampuscenko K, Morkuniene R, Krasauskas L, Smirnovas V, Tomita T, Borutaite V. Distinct Neurotoxic Effects of Extracellular Tau Species in Primary Neuronal-Glial Cultures. Molecular Neurobiology. PMID 33001416 DOI: 10.1007/s12035-020-02150-7   
2020 Thompson TB, Chaggar P, Kuhl E, Goriely A, . Protein-protein interactions in neurodegenerative diseases: A conspiracy theory. Plos Computational Biology. 16: e1008267. PMID 33048932 DOI: 10.1371/journal.pcbi.1008267   
2020 Al Mamun A, Rahman MM, Zaman S, Munira MS, Uddin MS, Rauf A, Banu N, Ashraf GM. Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease. Current Protein & Peptide Science. PMID 32964822 DOI: 10.2174/1389203721666200923153406   
2020 Shi WY, Wang ZT, Sun FR, Ma YH, Xu W, Shen XN, Dong Q, Tan L, Yu JT, Yu Y, . High pulse pressure is a risk factor for prodromal Alzheimer's disease: a longitudinal study. Aging. 12. PMID 32960784 DOI: 10.18632/aging.103678   
2020 Brosseron F, Kleemann K, Kolbe CC, Santarelli F, Castro-Gomez S, Tacik P, Latz E, Jessen F, Heneka MT. Interrelations of Alzheimer´s disease candidate biomarkers neurogranin, fatty acid binding protein 3 and ferritin to neurodegeneration and neuroinflammation. Journal of Neurochemistry. PMID 32894885 DOI: 10.1111/jnc.15175   
2020 Pappas C, Klinedinst BS, Le S, Wang Q, Larsen B, McLimans K, Lockhart SN, Allenspach-Jorn K, Mochel JP, Willette AA, . CSF glucose tracks regional tau progression based on Alzheimer's disease risk factors. Alzheimer's & Dementia (New York, N. Y.). 6: e12080. PMID 32864418 DOI: 10.1002/trc2.12080