Giles E. Hardingham - Publications

University of Edinburgh, Edinburgh, Scotland, United Kingdom 
NMDA receptors

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jiwaji Z, Márkus NM, McQueen J, Emelianova K, He X, Dando O, Chandran S, Hardingham GE. General anesthesia alters CNS and astrocyte expression of activity-dependent and activity-independent genes. Frontiers in Network Physiology. 3: 1216366. PMID 37670849 DOI: 10.3389/fnetp.2023.1216366  0.335
2023 Baxter PS, Dando O, Hardingham GE. Differential splicing choices made by neurons and astrocytes and their importance when investigating signal-dependent alternative splicing in neural cells. Frontiers in Molecular Neuroscience. 16: 1214439. PMID 37465362 DOI: 10.3389/fnmol.2023.1214439  0.375
2020 Booker SA, Simões de Oliveira L, Anstey NJ, Kozic Z, Dando OR, Jackson AD, Baxter PS, Isom LL, Sherman DL, Hardingham GE, Brophy PJ, Wyllie DJA, Kind PC. Input-Output Relationship of CA1 Pyramidal Neurons Reveals Intact Homeostatic Mechanisms in a Mouse Model of Fragile X Syndrome. Cell Reports. 32: 107988. PMID 32783927 DOI: 10.1016/J.Celrep.2020.107988  0.389
2020 Qiu J, Dando O, Febery JA, Fowler JH, Chandran S, Hardingham GE. Neuronal Activity and Its Role in Controlling Antioxidant Genes. International Journal of Molecular Sciences. 21. PMID 32178355 DOI: 10.3390/Ijms21061933  0.467
2020 Hardingham GE. Targeting Synaptic NMDA Receptor Co-agonism as a Therapy for Alzheimer's Disease? Cell Metabolism. 31: 439-440. PMID 32130875 DOI: 10.1016/J.Cmet.2020.02.009  0.366
2019 Zhao C, Devlin AC, Chouhan AK, Selvaraj BT, Stavrou M, Burr K, Brivio V, He X, Mehta AR, Story D, Shaw CE, Dando O, Hardingham GE, Miles GB, Chandran S. Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology. Glia. PMID 31841614 DOI: 10.1002/Glia.23761  0.341
2019 Bas-Orth C, Schneider J, Lewen A, McQueen J, Hasenpusch-Theil K, Theil T, Hardingham GE, Bading H, Kann O. The mitochondrial calcium uniporter is crucial for the generation of fast cortical network rhythms. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19887777. PMID 31722597 DOI: 10.1177/0271678X19887777  0.607
2019 Booker SA, Domanski APF, Dando OR, Jackson AD, Isaac JTR, Hardingham GE, Wyllie DJA, Kind PC. Altered dendritic spine function and integration in a mouse model of fragile X syndrome. Nature Communications. 10: 4813. PMID 31645626 DOI: 10.1038/S41467-019-11891-6  0.356
2019 Hardingham G. NMDA receptor C-terminal signaling in development, plasticity, and disease. F1000research. 8. PMID 31508206 DOI: 10.12688/F1000Research.19925.1  0.434
2019 Marwick KFM, Skehel PA, Hardingham GE, Wyllie DJA. The human NMDA receptor GluN2A variant influences channel blocker potency. Pharmacology Research & Perspectives. 7: e00495. PMID 31249692 DOI: 10.1002/Prp2.495  0.387
2019 Marwick KFM, Hansen KB, Skehel PA, Hardingham GE, Wyllie DJA. Functional assessment of triheteromeric NMDA receptors containing a human variant associated with epilepsy. The Journal of Physiology. PMID 30604514 DOI: 10.1113/Jp277292  0.38
2018 Johnstone M, Vasistha NA, Barbu MC, Dando O, Burr K, Christopher E, Glen S, Robert C, Fetit R, Macleod KG, Livesey MR, Clair DS, Blackwood DHR, Millar K, Carragher NO, ... Hardingham GE, et al. Reversal of proliferation deficits caused by chromosome 16p13.11 microduplication through targeting NFκB signaling: an integrated study of patient-derived neuronal precursor cells, cerebral organoids and in vivo brain imaging. Molecular Psychiatry. PMID 30401811 DOI: 10.1038/S41380-018-0292-1  0.306
2018 McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, Wyllie DJA, O'Dell TJ, Grant SGN, Hardingham GE, Komiyama NH. The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences. Cell Reports. 25: 841-851.e4. PMID 30355491 DOI: 10.1016/J.Celrep.2018.09.089  0.392
2018 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Hardingham GE, et al. Author Correction: Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 9: 16176. PMID 29405195 DOI: 10.1038/Ncomms16176  0.389
2018 Selvaraj BT, Livesey MR, Zhao C, Gregory JM, James OT, Cleary EM, Chouhan AK, Gane AB, Perkins EM, Dando O, Lillico SG, Lee YB, Nishimura AL, Poreci U, Thankamony S, ... ... Hardingham GE, et al. C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity. Nature Communications. 9: 347. PMID 29367641 DOI: 10.1038/S41467-017-02729-0  0.396
2017 Hardingham GE, Pruunsild P, Greenberg ME, Bading H. Lineage divergence of activity-driven transcription and evolution of cognitive ability. Nature Reviews. Neuroscience. PMID 29167525 DOI: 10.1038/Nrn.2017.138  0.691
2017 Hardingham GE, Pruunsild P, Greenberg ME, Bading H. Lineage divergence of activity-driven transcription and evolution of cognitive ability. Nature Reviews. Neuroscience. PMID 29167525 DOI: 10.1038/Nrn.2017.138  0.691
2017 Burnside SW, Hardingham GE. Transcriptional regulators of redox balance and other homeostatic processes with the potential to alter neurodegenerative disease trajectory. Biochemical Society Transactions. PMID 29150527 DOI: 10.1042/Bst20170013  0.35
2017 Marwick KFM, Hardingham GE. Transfection in Primary Cultured Neuronal Cells. Methods in Molecular Biology (Clifton, N.J.). 1677: 137-144. PMID 28986870 DOI: 10.1007/978-1-4939-7321-7_6  0.365
2017 Baxter PS, Bell KFS, Hasel P, Kaindl AM, Fricker M, Thomson D, Cregan SP, Gillingwater TH, Hardingham GE. Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nature Communications. 8: 16158. PMID 28891555 DOI: 10.1038/Ncomms16158  0.424
2017 Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK. Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome. Neuron. 95: 550-563.e5. PMID 28772121 DOI: 10.1016/J.Neuron.2017.07.013  0.373
2017 Pardo L, Valor LM, Eraso-Pichot A, Barco A, Golbano A, Hardingham GE, Masgrau R, Galea E. CREB Regulates Distinct Adaptive Transcriptional Programs in Astrocytes and Neurons. Scientific Reports. 7: 6390. PMID 28743894 DOI: 10.1038/S41598-017-06231-X  0.46
2017 McQueen J, Ryan TJ, McKay S, Marwick KF, Baxter PE, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJ, Grant SG, McColl B, Komiyama N, Hardingham GE. Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of DAPK1. Elife. 6. PMID 28731405 DOI: 10.7554/Elife.17161  0.429
2017 Hasel P, Dando O, Jiwaji Z, Baxter P, Todd AC, Heron S, Márkus NM, McQueen J, Hampton DW, Torvell M, Tiwari SS, McKay S, Eraso-Pichot A, Zorzano A, Masgrau R, ... ... Hardingham GE, et al. Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism. Nature Communications. 8: 15132. PMID 28462931 DOI: 10.1038/Ncomms15132  0.435
2017 McQueen J, Ryan TJ, McKay S, Marwick K, Baxter P, Carpanini SM, Wishart TM, Gillingwater TH, Manson JC, Wyllie DJA, Grant SGN, McColl BW, Komiyama NH, Hardingham GE. Author response: Pro-death NMDA receptor signaling is promoted by the GluN2B C-terminus independently of Dapk1 Elife. DOI: 10.7554/Elife.17161.024  0.404
2017 Jiwaji Z, Hasel P, Chandran S, Hardingham G. The role of neuronal activity in regulating metabolism in mouse and human astrocytes The Lancet. 389: S51. DOI: 10.1016/S0140-6736(17)30447-6  0.385
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Hardingham GE, et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife. 5. PMID 27692071 DOI: 10.7554/Elife.20337  0.439
2016 Baxter P, Hardingham GE. Adaptive regulation of the brain's antioxidant defences by neurons and astrocytes. Free Radical Biology & Medicine. PMID 27365123 DOI: 10.1016/J.Freeradbiomed.2016.06.027  0.436
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJ, Hardingham GE, Chandran S. Hypothermic Preconditioning Reverses Tau Ontogenesis in Human Cortical Neurons and is Mimicked by Protein Phosphatase 2A Inhibition. Ebiomedicine. 3: 141-54. PMID 26870825 DOI: 10.1016/J.Ebiom.2015.12.010  0.331
2016 Márkus NM, Hasel P, Qiu J, Bell KF, Heron S, Kind PC, Dando O, Simpson TI, Hardingham GE. Expression of mRNA Encoding Mcu and Other Mitochondrial Calcium Regulatory Genes Depends on Cell Type, Neuronal Subtype, and Ca2+ Signaling. Plos One. 11: e0148164. PMID 26828201 DOI: 10.1371/Journal.Pone.0148164  0.389
2016 Marwick K, Skehel P, Hardingham G, Wyllie D. Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons. Lancet (London, England). S65. PMID 26312887 DOI: 10.1016/S0140-6736(15)60380-4  0.382
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Hardingham GE, et al. Author response: Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons Elife. DOI: 10.7554/Elife.20337.021  0.413
2016 Rzechorzek NM, Connick P, Livesey MR, Borooah S, Patani R, Burr K, Story D, Wyllie DJA, Hardingham GE, Chandran S. Hypothermic modulation of human cortical neurons to explore a role for tau protein in neuroprotection The Lancet. 387: S88. DOI: 10.1016/S0140-6736(16)00475-X  0.348
2015 Livesey MR, Magnani D, Hardingham GE, Chandran S, Wyllie DJ. Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. The Journal of Physiology. PMID 26608229 DOI: 10.1113/Jp270660  0.37
2015 Bell KF, Al-Mubarak B, Martel MA, McKay S, Wheelan N, Hasel P, Márkus NM, Baxter P, Deighton RF, Serio A, Bilican B, Chowdhry S, Meakin PJ, Ashford ML, Wyllie DJ, ... ... Hardingham GE, et al. Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2. Nature Communications. 6: 7066. PMID 25967870 DOI: 10.1038/Ncomms8066  0.425
2015 Baxter PS, Bell KF, Hasel P, Kaindl AM, Fricker M, Thomson D, Cregan SP, Gillingwater TH, Hardingham GE. Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system. Nature Communications. 6: 6761. PMID 25854456 DOI: 10.1038/Ncomms7761  0.492
2014 Hasel P, Mckay S, Qiu J, Hardingham GE. Selective dendritic susceptibility to bioenergetic, excitotoxic and redox perturbations in cortical neurons. Biochimica Et Biophysica Acta. PMID 25541281 DOI: 10.1016/J.Bbamcr.2014.12.021  0.395
2014 Deighton RF, Márkus NM, Al-Mubarak B, Bell KF, Papadia S, Meakin PJ, Chowdhry S, Hayes JD, Hardingham GE. Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes. Proceedings of the National Academy of Sciences of the United States of America. 111: E1818-20. PMID 24753562 DOI: 10.1073/Pnas.1402097111  0.465
2014 Livesey MR, Bilican B, Qiu J, Rzechorzek NM, Haghi G, Burr K, Hardingham GE, Chandran S, Wyllie DJ. Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4070-5. PMID 24623784 DOI: 10.1523/Jneurosci.5410-13.2014  0.375
2014 Bilican B, Livesey MR, Haghi G, Qiu J, Burr K, Siller R, Hardingham GE, Wyllie DJ, Chandran S. Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells. Plos One. 9: e85932. PMID 24465796 DOI: 10.1371/Journal.Pone.0085932  0.373
2014 Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, ... ... Hardingham GE, et al. Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. Antioxidants & Redox Signaling. 20: 2907-22. PMID 24219064 DOI: 10.1089/Ars.2013.5455  0.364
2013 Qiu J, Tan YW, Hagenston AM, Martel MA, Kneisel N, Skehel PA, Wyllie DJ, Bading H, Hardingham GE. Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals. Nature Communications. 4: 2034. PMID 23774321 DOI: 10.1038/Ncomms3034  0.645
2013 Gupta K, Hardingham GE, Chandran S. NMDA receptor-dependent glutamate excitotoxicity in human embryonic stem cell-derived neurons. Neuroscience Letters. 543: 95-100. PMID 23518152 DOI: 10.1016/J.Neulet.2013.03.010  0.715
2013 McKay S, Bengtson CP, Bading H, Wyllie DJ, Hardingham GE. Recovery of NMDA receptor currents from MK-801 blockade is accelerated by Mg2+ and memantine under conditions of agonist exposure. Neuropharmacology. 74: 119-25. PMID 23402996 DOI: 10.1016/J.Neuropharm.2013.01.024  0.642
2013 Wyllie DJ, Livesey MR, Hardingham GE. Influence of GluN2 subunit identity on NMDA receptor function. Neuropharmacology. 74: 4-17. PMID 23376022 DOI: 10.1016/J.Neuropharm.2013.01.016  0.408
2013 Gupta K, Chandran S, Hardingham GE. Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration. British Journal of Clinical Pharmacology. 75: 907-18. PMID 23126226 DOI: 10.1111/Bcp.12022  0.666
2013 Soriano FX, Chawla S, Skehel P, Hardingham GE. SMRT-mediated co-shuttling enables export of class IIa HDACs independent of their CaM kinase phosphorylation sites. Journal of Neurochemistry. 124: 26-35. PMID 23083128 DOI: 10.1111/Jnc.12058  0.708
2012 Camacho A, Rodriguez-Cuenca S, Blount M, Prieur X, Barbarroja N, Fuller M, Hardingham GE, Vidal-Puig A. Ablation of PGC1 beta prevents mTOR dependent endoplasmic reticulum stress response. Experimental Neurology. 237: 396-406. PMID 22771762 DOI: 10.1016/J.Expneurol.2012.06.031  0.328
2012 McMahon AC, Barnett MW, O'Leary TS, Stoney PN, Collins MO, Papadia S, Choudhary JS, Komiyama NH, Grant SG, Hardingham GE, Wyllie DJ, Kind PC. SynGAP isoforms exert opposing effects on synaptic strength. Nature Communications. 3: 900. PMID 22692543 DOI: 10.1038/Ncomms1900  0.359
2012 Patani R, Lewis PA, Trabzuni D, Puddifoot CA, Wyllie DJ, Walker R, Smith C, Hardingham GE, Weale M, Hardy J, Chandran S, Ryten M. Investigating the utility of human embryonic stem cell-derived neurons to model ageing and neurodegenerative disease using whole-genome gene expression and splicing analysis. Journal of Neurochemistry. 122: 738-51. PMID 22681703 DOI: 10.1111/J.1471-4159.2012.07825.X  0.37
2012 Puddifoot C, Martel MA, Soriano FX, Camacho A, Vidal-Puig A, Wyllie DJ, Hardingham GE. PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6995-7000. PMID 22593067 DOI: 10.1523/Jneurosci.6407-11.2012  0.476
2012 Edman S, McKay S, Macdonald LJ, Samadi M, Livesey MR, Hardingham GE, Wyllie DJ. TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology. 63: 441-9. PMID 22579927 DOI: 10.1016/J.Neuropharm.2012.04.027  0.373
2012 Martel MA, Ryan TJ, Bell KF, Fowler JH, McMahon A, Al-Mubarak B, Komiyama NH, Horsburgh K, Kind PC, Grant SG, Wyllie DJ, Hardingham GE. The subtype of GluN2 C-terminal domain determines the response to excitotoxic insults. Neuron. 74: 543-56. PMID 22578505 DOI: 10.1016/J.Neuron.2012.03.021  0.392
2012 Bilican B, Serio A, Barmada SJ, Nishimura AL, Sullivan GJ, Carrasco M, Phatnani HP, Puddifoot CA, Story D, Fletcher J, Park IH, Friedman BA, Daley GQ, Wyllie DJ, Hardingham GE, et al. Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability. Proceedings of the National Academy of Sciences of the United States of America. 109: 5803-8. PMID 22451909 DOI: 10.1073/Pnas.1202922109  0.368
2012 Gupta K, Patani R, Baxter P, Serio A, Story D, Tsujita T, Hayes JD, Pedersen RA, Hardingham GE, Chandran S. Human embryonic stem cell derived astrocytes mediate non-cell-autonomous neuroprotection through endogenous and drug-induced mechanisms. Cell Death and Differentiation. 19: 779-87. PMID 22095276 DOI: 10.1038/Cdd.2011.154  0.701
2012 McKay S, Griffiths NH, Butters PA, Thubron EB, Hardingham GE, Wyllie DJ. Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. British Journal of Pharmacology. 166: 924-37. PMID 22022974 DOI: 10.1111/J.1476-5381.2011.01748.X  0.419
2011 Bell KF, Fowler JH, Al-Mubarak B, Horsburgh K, Hardingham GE. Activation of Nrf2-regulated glutathione pathway genes by ischemic preconditioning. Oxidative Medicine and Cellular Longevity. 2011: 689524. PMID 21904646 DOI: 10.1155/2011/689524  0.428
2011 Soriano FX, Hardingham GE. In cortical neurons HDAC3 activity suppresses RD4-dependent SMRT export. Plos One. 6: e21056. PMID 21695276 DOI: 10.1371/Journal.Pone.0021056  0.408
2011 Baxter PS, Martel MA, McMahon A, Kind PC, Hardingham GE. Pituitary adenylate cyclase-activating peptide induces long-lasting neuroprotection through the induction of activity-dependent signaling via the cyclic AMP response element-binding protein-regulated transcription co-activator 1. Journal of Neurochemistry. 118: 365-78. PMID 21623792 DOI: 10.1111/J.1471-4159.2011.07330.X  0.474
2011 Patani R, Hollins AJ, Wishart TM, Puddifoot CA, Alvarez S, de Lera AR, Wyllie DJ, Compston DA, Pedersen RA, Gillingwater TH, Hardingham GE, Allen ND, Chandran S. Retinoid-independent motor neurogenesis from human embryonic stem cells reveals a medial columnar ground state. Nature Communications. 2: 214. PMID 21364553 DOI: 10.1038/Ncomms1216  0.325
2011 Bell KF, Hardingham GE. The influence of synaptic activity on neuronal health. Current Opinion in Neurobiology. 21: 299-305. PMID 21292474 DOI: 10.1016/J.Conb.2011.01.002  0.439
2011 Bell KF, Al-Mubarak B, Fowler JH, Baxter PS, Gupta K, Tsujita T, Chowdhry S, Patani R, Chandran S, Horsburgh K, Hayes JD, Hardingham GE. Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning. Proceedings of the National Academy of Sciences of the United States of America. 108: E1-2; author reply E. PMID 21177433 DOI: 10.1073/Pnas.1015229108  0.672
2011 Hardingham GE, Lipton SA. Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes. Antioxidants & Redox Signaling. 14: 1421-4. PMID 20977364 DOI: 10.1089/Ars.2010.3573  0.362
2011 Bell KF, Hardingham GE. CNS peroxiredoxins and their regulation in health and disease. Antioxidants & Redox Signaling. 14: 1467-77. PMID 20868292 DOI: 10.1089/Ars.2010.3567  0.363
2011 Soriano FX, Léveillé F, Papadia S, Bell KF, Puddifoot C, Hardingham GE. Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptor-γ coactivator-1α and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxidants & Redox Signaling. 14: 1425-36. PMID 20849372 DOI: 10.1089/Ars.2010.3568  0.5
2010 Hardingham GE, Bading H. Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders. Nature Reviews. Neuroscience. 11: 682-96. PMID 20842175 DOI: 10.1038/Nrn2911  0.709
2010 Fricker M, Papadia S, Hardingham GE, Tolkovsky AM. Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons. Journal of Neurochemistry. 114: 772-83. PMID 20477944 DOI: 10.1111/J.1471-4159.2010.06804.X  0.372
2010 Hardingham GE, Patani R, Baxter P, Wyllie DJ, Chandran S. Human embryonic stem cell-derived neurons as a tool for studying neuroprotection and neurodegeneration. Molecular Neurobiology. 42: 97-102. PMID 20431962 DOI: 10.1007/S12035-010-8136-2  0.371
2010 Léveillé F, Papadia S, Fricker M, Bell KF, Soriano FX, Martel MA, Puddifoot C, Habel M, Wyllie DJ, Ikonomidou C, Tolkovsky AM, Hardingham GE. Suppression of the intrinsic apoptosis pathway by synaptic activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2623-35. PMID 20164347 DOI: 10.1523/Jneurosci.5115-09.2010  0.465
2009 Léveillé F, Soriano FX, Papadia S, Hardingham GE. Excitotoxic insults lead to peroxiredoxin hyperoxidation. Oxidative Medicine and Cellular Longevity. 2: 110-3. PMID 20357934 DOI: 10.4161/Oxim.2.2.8300  0.498
2009 Hardingham GE. Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochemical Society Transactions. 37: 1147-60. PMID 19909238 DOI: 10.1042/Bst0371147  0.455
2009 Al-Mubarak B, Soriano FX, Hardingham GE. Synaptic NMDAR activity suppresses FOXO1 expression via a cis-acting FOXO binding site: FOXO1 is a FOXO target gene. Channels (Austin, Tex.). 3: 233-8. PMID 19690465 DOI: 10.4161/Chan.3.4.9381  0.485
2009 Soriano FX, Papadia S, Bell KF, Hardingham GE. Role of histone acetylation in the activity-dependent regulation of sulfiredoxin and sestrin 2. Epigenetics : Official Journal of the Dna Methylation Society. 4: 152-8. PMID 19430206 DOI: 10.4161/Epi.4.3.8753  0.419
2009 Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE. Transcriptional regulation of the AP-1 and Nrf2 target gene sulfiredoxin. Molecules and Cells. 27: 279-82. PMID 19326073 DOI: 10.1007/S10059-009-0050-Y  0.398
2009 Martel MA, Soriano FX, Baxter P, Rickman C, Duncan R, Wyllie DJ, Hardingham GE. Inhibiting pro-death NMDA receptor signaling dependent on the NR2 PDZ ligand may not affect synaptic function or synaptic NMDA receptor signaling to gene expression. Channels (Austin, Tex.). 3: 12-5. PMID 19221512 DOI: 10.4161/Chan.3.1.7864  0.518
2009 Wahl AS, Buchthal B, Rode F, Bomholt SF, Freitag HE, Hardingham GE, Rønn LC, Bading H. Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors. Neuroscience. 158: 344-52. PMID 18616988 DOI: 10.1016/J.Neuroscience.2008.06.018  0.704
2009 Martel MA, Wyllie DJ, Hardingham GE. In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience. 158: 334-43. PMID 18378405 DOI: 10.1016/J.Neuroscience.2008.01.080  0.481
2008 Soriano FX, Martel MA, Papadia S, Vaslin A, Baxter P, Rickman C, Forder J, Tymianski M, Duncan R, Aarts M, Clarke P, Wyllie DJ, Hardingham GE. Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10696-710. PMID 18923045 DOI: 10.1523/Jneurosci.1207-08.2008  0.759
2008 Soriano FX, Léveillé F, Papadia S, Higgins LG, Varley J, Baxter P, Hayes JD, Hardingham GE. Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione. Journal of Neurochemistry. 107: 533-43. PMID 18761713 DOI: 10.1111/J.1471-4159.2008.05648.X  0.428
2008 Ramage L, Martel MA, Hardingham GE, Salter DM. NMDA receptor expression and activity in osteoarthritic human articular chondrocytes. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 16: 1576-84. PMID 18554934 DOI: 10.1016/J.Joca.2008.04.023  0.496
2008 Papadia S, Soriano FX, Léveillé F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, ... ... Hardingham GE, et al. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nature Neuroscience. 11: 476-87. PMID 18344994 DOI: 10.1038/Nn2071  0.455
2008 Ramage L, Hardingham G, Salter D. 161 NMDA RECEPTOR FUNCTION IN OSTEOARTHRITIC CHONDROCYTES IS DEPENDENT ON β1 INTEGRINS Osteoarthritis and Cartilage. 16: S82. DOI: 10.1016/S1063-4584(08)60207-1  0.342
2007 Papadia S, Hardingham GE. The dichotomy of NMDA receptor signaling. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 13: 572-9. PMID 18000068 DOI: 10.1177/10738584070130060401  0.461
2007 Soriano FX, Hardingham GE. Compartmentalized NMDA receptor signalling to survival and death. The Journal of Physiology. 584: 381-7. PMID 17690142 DOI: 10.1113/Jphysiol.2007.138875  0.45
2007 Hardingham NR, Hardingham GE, Fox KD, Jack JJ. Presynaptic efficacy directs normalization of synaptic strength in layer 2/3 rat neocortex after paired activity. Journal of Neurophysiology. 97: 2965-75. PMID 17267749 DOI: 10.1152/Jn.01352.2006  0.323
2007 Salter D, Ramage L, Hardingham G. NMDA RECEPTORS ON CHONDROCYTES MODULATE MECHANOTRANSDUCTION Osteoarthritis and Cartilage. 15: C8. DOI: 10.1016/S1063-4584(07)61621-5  0.372
2007 Ramage L, Hardingham G, Salter D. P214 NMDA receptor signalling in human osteoarthritic chondrocytes. Osteoarthritis and Cartilage. 15: B142. DOI: 10.1016/S1063-4584(07)61569-6  0.382
2006 Hardingham GE. Pro-survival signalling from the NMDA receptor. Biochemical Society Transactions. 34: 936-8. PMID 17052231 DOI: 10.1042/Bst0340936  0.427
2006 Hardingham NR, Bannister NJ, Read JC, Fox KD, Hardingham GE, Jack JJ. Extracellular calcium regulates postsynaptic efficacy through group 1 metabotropic glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6337-45. PMID 16763042 DOI: 10.1523/Jneurosci.5128-05.2006  0.408
2006 Soriano FX, Papadia S, Hofmann F, Hardingham NR, Bading H, Hardingham GE. Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4509-18. PMID 16641230 DOI: 10.1523/Jneurosci.0455-06.2006  0.676
2006 Hardingham GE. 2B synaptic or extrasynaptic determines signalling from the NMDA receptor. The Journal of Physiology. 572: 614-5. PMID 16581856 DOI: 10.1113/Jphysiol.2006.109603  0.459
2006 McKenzie G, Ward G, Stallwood Y, Briend E, Papadia S, Lennard A, Turner M, Champion B, Hardingham GE. Cellular Notch responsiveness is defined by phosphoinositide 3-kinase-dependent signals. Bmc Cell Biology. 7: 10. PMID 16507111 DOI: 10.1186/1471-2121-7-10  0.389
2006 Ramage L, Martel M, Hardingham G, Salter D. P186 EXPRESSION OF FUNCTIONAL NMDA RECEPTORS IN HUMAN OA CHONDROCYTES Osteoarthritis and Cartilage. 14: S108. DOI: 10.1016/S1063-4584(07)60638-4  0.436
2005 Papadia S, Stevenson P, Hardingham NR, Bading H, Hardingham GE. Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4279-87. PMID 15858054 DOI: 10.1523/Jneurosci.5019-04.2005  0.7
2005 McKenzie GJ, Stevenson P, Ward G, Papadia S, Bading H, Chawla S, Privalsky M, Hardingham GE. Nuclear Ca2+ and CaM kinase IV specify hormonal- and Notch-responsiveness. Journal of Neurochemistry. 93: 171-85. PMID 15773917 DOI: 10.1111/J.1471-4159.2005.03010.X  0.79
2003 Pokorska A, Vanhoutte P, Arnold FJ, Silvagno F, Hardingham GE, Bading H. Synaptic activity induces signalling to CREB without increasing global levels of cAMP in hippocampal neurons. Journal of Neurochemistry. 84: 447-52. PMID 12558964 DOI: 10.1046/J.1471-4159.2003.01504.X  0.722
2003 Hardingham GE, Bading H. The Yin and Yang of NMDA receptor signalling. Trends in Neurosciences. 26: 81-9. PMID 12536131 DOI: 10.1016/S0166-2236(02)00040-1  0.672
2002 Hardingham GE, Bading H. Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated. Biochimica Et Biophysica Acta. 1600: 148-53. PMID 12445470 DOI: 10.1016/S1570-9639(02)00455-7  0.734
2002 Hardingham GE, Fukunaga Y, Bading H. Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nature Neuroscience. 5: 405-14. PMID 11953750 DOI: 10.1038/Nn835  0.716
2001 Hardingham GE, Arnold FJ, Bading H. A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Nature Neuroscience. 4: 565-6. PMID 11369935 DOI: 10.1038/88380  0.657
2001 Hardingham GE, Arnold FJ, Bading H. Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity. Nature Neuroscience. 4: 261-7. PMID 11224542 DOI: 10.1038/85109  0.707
2000 Hardingham GE, Bading H. Calcium signal processing in neuronal nuclei controls synaptically-evoked gene expression Biochemical Society Transactions. 28: A275-A275. DOI: 10.1042/Bst028A275C  0.686
1999 Hardingham GE, Bading H. Calcium as a versatile second messenger in the control of gene expression. Microscopy Research and Technique. 46: 348-55. PMID 10504212 DOI: 10.1002/(Sici)1097-0029(19990915)46:6<348::Aid-Jemt3>3.0.Co;2-A  0.669
1999 Hardingham GE, Chawla S, Cruzalegui FH, Bading H. Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels. Neuron. 22: 789-98. PMID 10230798 DOI: 10.1016/S0896-6273(00)80737-0  0.788
1999 Cruzalegui FH, Hardingham GE, Bading H. c-Jun functions as a calcium-regulated transcriptional activator in the absence of JNK/SAPK1 activation. The Embo Journal. 18: 1335-44. PMID 10064599 DOI: 10.1093/Emboj/18.5.1335  0.692
1999 Hardingham GE, Chawla S, Cruzalegui FH, Bading H. CONTROL OF RECRUITMENT AND ACTIVATION OF CBP DETERMINES GENE REGULATION BY NMDA RECEPTORS AND L-TYPE CALCIUM CHANNELS Biochemical Society Transactions. 27: A93-A93. DOI: 10.1042/Bst027A093B  0.784
1998 Hardingham GE, Bading H. Nuclear calcium: a key regulator of gene expression. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 11: 345-58. PMID 10191498 DOI: 10.1023/A:1009257909785  0.679
1998 Chawla S, Hardingham GE, Quinn DR, Bading H. CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV. Science (New York, N.Y.). 281: 1505-9. PMID 9727976 DOI: 10.1126/Science.281.5382.1505  0.79
1998 Hardingham GE, Cruzalegui FH, Chawla S, Bading H. Mechanisms controlling gene expression by nuclear calcium signals. Cell Calcium. 23: 131-4. PMID 9601608 DOI: 10.1016/S0143-4160(98)90111-7  0.801
1997 Bading H, Hardingham GE, Johnson CM, Chawla S. Gene regulation by nuclear and cytoplasmic calcium signals. Biochemical and Biophysical Research Communications. 236: 541-3. PMID 9245684 DOI: 10.1006/Bbrc.1997.7037  0.809
1997 Hardingham GE, Chawla S, Johnson CM, Bading H. Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression. Nature. 385: 260-5. PMID 9000075 DOI: 10.1038/385260A0  0.788
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