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Patrick L. McGeer, MD, University of British Columbia 1958,PhD,Princeton 1951, OC, OBC, FRSC, FRCP(C) - Publications

Affiliations: 
Medicine University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=19
Website:
http://en.wikipedia.org/wiki/Pat_McGeer

157 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Sabbagh MN, Shi J, Lee M, Arnold L, Al-Hasan Y, Heim J, McGeer P. Salivary beta amyloid protein levels are detectable and differentiate patients with Alzheimer's disease dementia from normal controls: preliminary findings. Bmc Neurology. 18: 155. PMID 30257642 DOI: 10.1186/S12883-018-1160-Y  0.318
2018 McGeer PL, McGeer E. Conquering Alzheimer's Disease by Self Treatment. Journal of Alzheimer's Disease : Jad. PMID 29562519 DOI: 10.3233/Jad-179913  0.339
2017 McGeer PL, Guo JP, Lee M, Kennedy K, McGeer EG. Alzheimer's Disease Can Be Spared by Nonsteroidal Anti-Inflammatory Drugs. Journal of Alzheimer's Disease : Jad. PMID 29103042 DOI: 10.3233/Jad-170706  0.347
2017 De Lorenzi E, Chiari M, Colombo R, Cretich M, Sola L, Vanna R, Gagni P, Bisceglia F, Morasso C, Lin JS, Lee M, McGeer PL, Barron AE. Evidence that the Human Innate Immune Peptide LL-37 may be a Binding Partner of Amyloid-β and Inhibitor of Fibril Assembly. Journal of Alzheimer's Disease : Jad. PMID 28731438 DOI: 10.3233/Jad-170223  0.301
2017 Sabbagh MN, Shi J, Arnold L, McGeer P. [P2-255]: SALIVARY AMYLOID-BETA PROTEIN LEVELS CAN DIAGNOSE ALZHEIMER DISEASE AND PREDICT ITS FUTURE ONSET Alzheimer's & Dementia. 13: P710-P711. DOI: 10.1016/J.Jalz.2017.06.907  0.303
2016 McGeer PL, Lee M, McGeer EG. A review of human diseases caused or exacerbated by aberrant complement activation. Neurobiology of Aging. 52: 12-22. PMID 28104543 DOI: 10.1016/J.Neurobiolaging.2016.12.017  0.302
2016 Lee M, Guo JP, Kennedy K, McGeer EG, McGeer PL. A Method for Diagnosing Alzheimer's Disease Based on Salivary Amyloid-β Protein 42 Levels. Journal of Alzheimer's Disease : Jad. PMID 27792013 DOI: 10.3233/Jad-160748  0.337
2016 McGeer PL, Rogers J, McGeer EG. Inflammation, Antiinflammatory Agents, and Alzheimer's Disease: The Last 22 Years. Journal of Alzheimer's Disease : Jad. 54: 853-857. PMID 27716676 DOI: 10.3233/Jad-160488  0.359
2016 Lee M, McGeer EG, McGeer PL. Quercetin, not caffeine, is a major neuroprotective component in coffee. Neurobiology of Aging. 46: 113-123. PMID 27479153 DOI: 10.1016/J.Neurobiolaging.2016.06.015  0.336
2015 Lee M, Wathier M, Love JA, McGeer E, McGeer PL. Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid. Neurobiology of Aging. PMID 26248865 DOI: 10.1016/J.Neurobiolaging.2015.06.018  0.311
2015 Zhu A, Wu Z, Meng J, McGeer PL, Zhu Y, Nakanishi H, Wu S. The Neuroprotective Effects of Ratanasampil on Oxidative Stress-Mediated Neuronal Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity. 2015: 792342. PMID 26064424 DOI: 10.1155/2015/792342  0.302
2015 O'Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P, Lyons T, Page D, Hanna D, Meara JR, Spanswick D, Guo JP, McGeer EG, McGeer PL, Hobson P. Lack of support for bexarotene as a treatment for Alzheimer's disease. Neuropharmacology. PMID 26025659 DOI: 10.1016/J.Neuropharm.2015.04.020  0.327
2015 Hashioka S, McGeer EG, Miyaoka T, Wake R, Horiguchi J, McGeer PL. Interferon-γ-induced neurotoxicity of human astrocytes. Cns & Neurological Disorders Drug Targets. 14: 251-6. PMID 25687700 DOI: 10.2174/1871527314666150217122305  0.343
2015 Lee M, Shi X, Barron AE, McGeer E, McGeer PL. Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation. Biochemical Pharmacology. 94: 130-41. PMID 25686659 DOI: 10.1016/J.Bcp.2015.02.003  0.326
2015 McGeer PL, McGeer EG. Targeting microglia for the treatment of Alzheimer's disease. Expert Opinion On Therapeutic Targets. 19: 497-506. PMID 25435348 DOI: 10.1517/14728222.2014.988707  0.338
2015 Lee M, McGeer E, McGeer PL. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of Aging. 36: 42-52. PMID 25169677 DOI: 10.1016/J.Neurobiolaging.2014.07.024  0.351
2013 McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathologica. 126: 479-97. PMID 24052108 DOI: 10.1007/S00401-013-1177-7  0.363
2013 Jantaratnotai N, Ling A, Cheng J, Schwab C, McGeer PL, McLarnon JG. Upregulation and expression patterns of the angiogenic transcription factor ets-1 in Alzheimer's disease brain. Journal of Alzheimer's Disease : Jad. 37: 367-77. PMID 23948889 DOI: 10.3233/Jad-122191  0.328
2013 Lee M, McGeer E, Kodela R, Kashfi K, McGeer PL. NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disorders. Glia. 61: 1724-34. PMID 23918470 DOI: 10.1002/Glia.22553  0.314
2013 Schwab C, Yu S, Wong W, McGeer EG, McGeer PL. GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 1073-88. PMID 23114513 DOI: 10.3233/Jad-2012-121330  0.367
2013 Lee M, McGeer E, McGeer PL. Neurotoxins released from interferon-gamma-stimulated human astrocytes. Neuroscience. 229: 164-75. PMID 23098801 DOI: 10.1016/J.Neuroscience.2012.10.033  0.34
2012 Schwab C, Yu S, McGeer PL. Optineurin is colocalized with ubiquitin in Marinesco bodies. Acta Neuropathologica. 123: 289-92. PMID 22101367 DOI: 10.1007/S00401-011-0915-Y  0.339
2012 Schwab C, Yu S, McGeer EG, McGeer PL. Optineurin in Huntington's disease intranuclear inclusions. Neuroscience Letters. 506: 149-54. PMID 22085693 DOI: 10.1016/J.Neulet.2011.10.070  0.313
2012 Lee M, Kwon BM, Kwon BM, Suk K, McGeer E, McGeer PL. Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 173-86. PMID 21796424 DOI: 10.1007/S11481-011-9300-9  0.308
2012 Lee M, Guo J, Schwab C, McGeer E, McGeer P. P2-434: Aurin tricarboxylic acid may help Alzheimer's disease and other conditions by blocking the MAC of complement Alzheimer's & Dementia. 8: P418-P418. DOI: 10.1016/J.Jalz.2012.05.2059  0.308
2011 Lee M, Kang Y, Suk K, Schwab C, Yu S, McGeer PL. Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein. The Journal of Biological Chemistry. 286: 41230-45. PMID 21990352 DOI: 10.1074/Jbc.M111.270470  0.327
2011 Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of Biological Chemistry. 286: 15095-105. PMID 21393248 DOI: 10.1074/Jbc.M110.199356  0.335
2010 Morawski M, Hartlage-Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, McGeer PL, Arendt T, Demuth HU, Rossner S. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathologica. 120: 195-207. PMID 20383514 DOI: 10.1007/S00401-010-0685-Y  0.367
2010 Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL. Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2533-45. PMID 20228251 DOI: 10.1096/Fj.09-149997  0.323
2010 McGeer EG, McGeer PL. Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. Journal of Alzheimer's Disease : Jad. 19: 355-61. PMID 20061650 DOI: 10.3233/Jad-2010-1219  0.353
2010 Guo JP, Yu S, McGeer PL. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy. Journal of Alzheimer's Disease : Jad. 19: 1359-70. PMID 20061605 DOI: 10.3233/Jad-2010-1331  0.325
2010 Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging. 31: 1503-15. PMID 18950899 DOI: 10.1016/J.Neurobiolaging.2008.08.019  0.305
2009 Lee M, Schwab C, Yu S, McGeer E, McGeer PL. Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide. Neurobiology of Aging. 30: 1523-34. PMID 19631409 DOI: 10.1016/J.Neurobiolaging.2009.06.001  0.303
2009 Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutink P, Höglinger G, Jamrozik Z, Jellinger KA, Kazantsev A, ... ... McGeer PL, et al. Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 16: 297-309. PMID 19364361 DOI: 10.1111/J.1468-1331.2008.02513.X  0.324
2009 Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL. TDP-43 pathology in familial British dementia. Acta Neuropathologica. 118: 303-11. PMID 19283396 DOI: 10.1007/S00401-009-0514-3  0.337
2008 Schwab C, Arai T, Hasegawa M, Yu S, McGeer PL. Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. Journal of Neuropathology and Experimental Neurology. 67: 1159-65. PMID 19018245 DOI: 10.1097/Nen.0B013E31818E8951  0.327
2008 Miklossy J, Steele JC, Yu S, McCall S, Sandberg G, McGeer EG, McGeer PL. Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). Acta Neuropathologica. 116: 625-37. PMID 18843496 DOI: 10.1007/S00401-008-0439-2  0.342
2008 Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, ... ... McGeer PL, et al. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation. 5: 36. PMID 18715507 DOI: 10.1186/1742-2094-5-36  0.35
2008 Hashioka S, Miklossy J, Schwab C, Klegeris A, McGeer PL. Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain. Journal of Alzheimer's Disease : Jad. 14: 345-52. PMID 18599961 DOI: 10.3233/Jad-2008-14309  0.352
2008 McGeer PL, McGeer EG. The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease. Experimental Neurology. 212: 235-8. PMID 18514193 DOI: 10.1016/J.Expneurol.2008.04.008  0.307
2008 McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 474-83. PMID 18044695 DOI: 10.1002/Mds.21751  0.312
2008 Miklossy J, Fein LA, McCall S, Kasas S, McGeer PL. P1-378: Concurrent Alzheimer's disease and Lyme neuroborreliosis: Persisting atypical cystic Forms of Borrelia burgdorferi in the brain and recovery of cognitive decline following antibiotic treatment Alzheimer's & Dementia. 4: T329-T330. DOI: 10.1016/J.Jalz.2008.05.960  0.309
2007 McGeer EG, McGeer PL. The role of anti-inflammatory agents in Parkinson's disease. Cns Drugs. 21: 789-97. PMID 17850169 DOI: 10.2165/00023210-200721100-00001  0.338
2007 Miklossy J, Qing H, Guo JP, Yu S, Wszolek ZK, Calne D, McGeer EG, McGeer PL. Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation. Acta Neuropathologica. 114: 243-54. PMID 17639429 DOI: 10.1007/S00401-007-0230-9  0.347
2007 Klegeris A, Choi HB, McLarnon JG, McGeer PL. Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. Journal of Neuroscience Research. 85: 2207-15. PMID 17526017 DOI: 10.1002/Jnr.21361  0.306
2007 Klegeris A, McGeer EG, McGeer PL. Therapeutic approaches to inflammation in neurodegenerative disease. Current Opinion in Neurology. 20: 351-7. PMID 17495632 DOI: 10.1097/Wco.0B013E3280Adc943  0.307
2007 Klegeris A, Schulzer M, Harper DG, McGeer PL. Increase in core body temperature of Alzheimer's disease patients as a possible indicator of chronic neuroinflammation: a meta-analysis. Gerontology. 53: 7-11. PMID 16940734 DOI: 10.1159/000095386  0.352
2007 McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiology of Aging. 28: 639-47. PMID 16697488 DOI: 10.1016/J.Neurobiolaging.2006.03.013  0.319
2006 Miklossy J, Arai T, Guo JP, Klegeris A, Yu S, McGeer EG, McGeer PL. LRRK2 expression in normal and pathologic human brain and in human cell lines. Journal of Neuropathology and Experimental Neurology. 65: 953-63. PMID 17021400 DOI: 10.1097/01.Jnen.0000235121.98052.54  0.368
2006 McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. Journal of Alzheimer's Disease : Jad. 9: 271-6. PMID 16914866 DOI: 10.3233/Jad-2006-9S330  0.346
2006 Guo JP, Arai T, Miklossy J, McGeer PL. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 1953-8. PMID 16446437 DOI: 10.1073/Pnas.0509386103  0.324
2006 Arai T, Miklossy J, Klegeris A, Guo JP, McGeer PL. Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 65: 19-25. PMID 16410745 DOI: 10.1097/01.Jnen.0000196133.74087.Cb  0.376
2005 McGeer EG, McGeer PL. Abeta immunotherapy and other means to remove amyloid. Current Drug Targets. Cns and Neurological Disorders. 4: 569-73. PMID 16266289 DOI: 10.2174/156800705774322067  0.319
2005 McGeer EG, Klegeris A, McGeer PL. Inflammation, the complement system and the diseases of aging. Neurobiology of Aging. 26: 94-7. PMID 16198446 DOI: 10.1016/J.Neurobiolaging.2005.08.008  0.344
2004 McGeer PL, McGeer EG. Inflammation and the degenerative diseases of aging. Annals of the New York Academy of Sciences. 1035: 104-16. PMID 15681803 DOI: 10.1196/Annals.1332.007  0.353
2004 McGeer PL, McGeer E. Immunotherapy for Alzheimer's disease. Science of Aging Knowledge Environment : Sage Ke. 2004: pe29. PMID 15243154 DOI: 10.1126/Sageke.2004.27.Pe29  0.351
2004 Klegeris A, Maguire J, McGeer PL. S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity. Journal of Neuroimmunology. 152: 73-7. PMID 15223239 DOI: 10.1016/J.Jneuroim.2004.04.001  0.308
2004 McGeer PL, McGeer EG. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism & Related Disorders. 10: S3-7. PMID 15109580 DOI: 10.1016/J.Parkreldis.2004.01.005  0.301
2004 Akiyama H, McGeer PL. Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease. Nature Medicine. 10: 117-8; author reply . PMID 14760408 DOI: 10.1038/Nm0204-117  0.304
2004 Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Schwab C, McGeer PL. Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. Acta Neuropathologica. 107: 53-8. PMID 14586629 DOI: 10.1007/S00401-003-0783-1  0.363
2004 Miklossy J, Arai T, Schwab C, Steele JC, McGeer PL. P3-368 Neuronal and glial fibrillary tangles in parkinsonism dementia of Guam are more extensive and severe than in Alzheimer disease and other tauopathies Neurobiology of Aging. 25: S460. DOI: 10.1016/S0197-4580(04)81517-3  0.34
2003 McGeer EG, McGeer PL. Inflammatory processes in Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 741-9. PMID 12921904 DOI: 10.1016/S0278-5846(03)00124-6  0.378
2003 Schwab C, Hosokawa M, Akiyama H, McGeer PL. Familial British dementia: colocalization of furin and ABri amyloid. Acta Neuropathologica. 106: 278-84. PMID 12883829 DOI: 10.1007/S00401-003-0735-9  0.353
2003 McGeer EG, McGeer PL. Clinically tested drugs for Alzheimer's disease. Expert Opinion On Investigational Drugs. 12: 1143-51. PMID 12831349 DOI: 10.1517/13543784.12.7.1143  0.34
2003 McGeer PL, McGeer E. Is there a future for vaccination as a treatment for Alzheimer's disease? Neurobiology of Aging. 24: 391-5. PMID 12600715 DOI: 10.1016/S0197-4580(02)00157-4  0.305
2002 McGeer PL, McGeer EG. Innate immunity, local inflammation, and degenerative disease. Science of Aging Knowledge Environment : Sage Ke. 2002: re3. PMID 14602998 DOI: 10.1126/Sageke.2002.29.Re3  0.357
2002 McGeer PL, McGeer EG. Local neuroinflammation and the progression of Alzheimer's disease. Journal of Neurovirology. 8: 529-38. PMID 12476347 DOI: 10.1080/13550280290100969  0.352
2002 McGeer PL, McGeer EG. The possible role of complement activation in Alzheimer disease. Trends in Molecular Medicine. 8: 519-23. PMID 12421685 DOI: 10.1016/S1471-4914(02)02422-X  0.352
2001 McGeer EG, McGeer PL. Chronic inflammation in Alzheimer's disease offers therapeutic opportunities. Expert Review of Neurotherapeutics. 1: 53-60. PMID 19811046 DOI: 10.1586/14737175.1.1.53  0.367
2001 McGeer EG, Yasojima K, Schwab C, McGeer PL. The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases. Neurobiology of Aging. 22: 843-8. PMID 11754991 DOI: 10.1016/S0197-4580(01)00288-3  0.374
2001 McGeer PL, McGeer EG. Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Archives of Neurology. 58: 1790-2. PMID 11708985 DOI: 10.1001/Archneur.58.11.1790  0.309
2001 Arai T, Ikeda K, Akiyama H, Shikamoto Y, Tsuchiya K, Yagishita S, Beach T, Rogers J, Schwab C, McGeer PL. Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathologica. 101: 167-73. PMID 11271372 DOI: 10.1007/S004010000283  0.355
2001 Yasojima K, Akiyama H, McGeer EG, McGeer PL. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neuroscience Letters. 297: 97-100. PMID 11121879 DOI: 10.1016/S0304-3940(00)01675-X  0.346
2000 Yasojima K, Schwab C, McGeer EG, McGeer PL. Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Research. 887: 80-9. PMID 11134592 DOI: 10.1016/S0006-8993(00)02970-X  0.373
2000 McGeer PL, McGeer EG, Yasojima K. Alzheimer disease and neuroinflammation. Journal of Neural Transmission. Supplementum. 59: 53-7. PMID 10961418 DOI: 10.1007/978-3-7091-6781-6_8  0.367
2000 Schwab C, DeMaggio AJ, Ghoshal N, Binder LI, Kuret J, McGeer PL. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiology of Aging. 21: 503-10. PMID 10924763 DOI: 10.1016/S0197-4580(00)00110-X  0.336
2000 Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, ... ... McGeer PL, et al. Inflammation and Alzheimer's disease. Neurobiology of Aging. 21: 383-421. PMID 10858586 DOI: 10.1016/S0197-4580(00)00124-X  0.358
2000 Yasojima K, Kuret J, DeMaggio AJ, McGeer E, McGeer PL. Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain Research. 865: 116-20. PMID 10814741 DOI: 10.1016/S0006-8993(00)02200-9  0.355
1999 Schwab C, Schulzer M, Steele JC, McGeer PL. On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam. Neurobiology of Aging. 20: 57-63. PMID 10466894 DOI: 10.1016/S0197-4580(99)00005-6  0.317
1999 Klegeris A, Walker DG, McGeer PL. Toxicity of human THP-1 monocytic cells towards neuron-like cells is reduced by non-steroidal anti-inflammatory drugs (NSAIDs). Neuropharmacology. 38: 1017-25. PMID 10428420 DOI: 10.1016/S0028-3908(99)00014-3  0.327
1999 Yasojima K, McGeer EG, McGeer PL. Complement regulators C1 inhibitor and CD59 do not significantly inhibit complement activation in Alzheimer disease. Brain Research. 833: 297-301. PMID 10375708 DOI: 10.1016/S0006-8993(99)01514-0  0.302
1999 Yasojima K, Schwab C, McGeer EG, McGeer PL. Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Research. 830: 226-36. PMID 10366679 DOI: 10.1016/S0006-8993(99)01389-X  0.352
1999 McGeer PL, McGeer EG. Inflammation of the brain in Alzheimer's disease: implications for therapy. Journal of Leukocyte Biology. 65: 409-15. PMID 10204568 DOI: 10.1002/Jlb.65.4.409  0.368
1999 Yasojima K, Schwab C, McGeer EG, McGeer PL. Up-regulated production and activation of the complement system in Alzheimer's disease brain. The American Journal of Pathology. 154: 927-36. PMID 10079271 DOI: 10.1016/S0002-9440(10)65340-0  0.334
1999 Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 25: 324-31. PMID 10028915 DOI: 10.1002/(Sici)1098-1136(19990215)25:4<324::Aid-Glia2>3.0.Co;2-5  0.316
1998 Schwab C, Akiyama H, McGeer EG, McGeer PL. Extracellular neurofibrillary tangles are immunopositive for the 40 carboxy-terminal sequence of beta-amyloid protein. Journal of Neuropathology and Experimental Neurology. 57: 1131-7. PMID 9862635 DOI: 10.1097/00005072-199812000-00004  0.323
1998 Walker DG, Kim SU, McGeer PL. Expression of complement C4 and C9 genes by human astrocytes. Brain Research. 809: 31-8. PMID 9795119 DOI: 10.1016/S0006-8993(98)00811-7  0.303
1998 McGeer PL, McGeer EG. Glial cell reactions in neurodegenerative diseases: pathophysiology and therapeutic interventions. Alzheimer Disease and Associated Disorders. 12: S1-6. PMID 9769023 DOI: 10.1097/00002093-199803001-00001  0.377
1998 McGeer EG, McGeer PL. The importance of inflammatory mechanisms in Alzheimer disease. Experimental Gerontology. 33: 371-8. PMID 9762518 DOI: 10.1016/S0531-5565(98)00013-8  0.379
1998 Takami K, Matsuo A, Terai K, Walker DG, McGeer EG, McGeer PL. Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease. Brain Research. 802: 89-97. PMID 9748519 DOI: 10.1016/S0006-8993(98)00552-6  0.347
1998 McGeer PL, Kawamata T, McGeer EG. Localization and possible functions of presenilins in brain. Reviews in the Neurosciences. 9: 1-15. PMID 9683324 DOI: 10.1515/Revneuro.1998.9.1.1  0.351
1998 McGeer EG, McGeer PL. The future use of complement inhibitors for the treatment of neurological diseases. Drugs. 55: 739-46. PMID 9617589 DOI: 10.2165/00003495-199855060-00001  0.309
1998 Walker DG, Beach TG, Xu R, Lile J, Beck KD, McGeer EG, McGeer PL. Expression of the proto-oncogene Ret, a component of the GDNF receptor complex, persists in human substantia nigra neurons in Parkinson's disease. Brain Research. 792: 207-17. PMID 9593897 DOI: 10.1016/S0006-8993(98)00131-0  0.323
1997 Wszolek ZK, Vieregge P, Uitti RJ, Gasser T, Yasuhara O, McGeer P, Berry K, Calne DB, Vingerhoets FJ, Klein C, Pfeiffer RF. German-Canadian family (family A) with parkinsonism, amyotrophy, and dementia - Longitudinal observations. Parkinsonism & Related Disorders. 3: 125-39. PMID 18591067 DOI: 10.1016/S1353-8020(97)00013-8  0.329
1997 Shen Y, Li R, McGeer EG, McGeer PL. Neuronal expression of mRNAs for complement proteins of the classical pathway in Alzheimer brain. Brain Research. 769: 391-5. PMID 9374212 DOI: 10.1016/S0006-8993(97)00850-0  0.334
1997 Webster S, Lue LF, Brachova L, Tenner AJ, McGeer PL, Terai K, Walker DG, Bradt B, Cooper NR, Rogers J. Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiology of Aging. 18: 415-21. PMID 9330973 DOI: 10.1016/S0197-4580(97)00042-0  0.37
1997 Yasuhara O, Matsuo A, Terai K, Walker DG, Berger AE, Akiguchi I, Kimura J, McGeer PL. Expression of interleukin-1 receptor antagonist protein in post-mortem human brain tissues of Alzheimer's disease and control cases. Acta Neuropathologica. 93: 414-20. PMID 9113207 DOI: 10.1007/S004010050633  0.345
1997 Takami K, Terai K, Matsuo A, Walker DG, McGeer PL. Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer's disease brains. Brain Research. 748: 122-30. PMID 9067452 DOI: 10.1016/S0006-8993(96)01274-7  0.35
1997 Klegeris A, Walker DG, McGeer PL. Interaction of Alzheimer beta-amyloid peptide with the human monocytic cell line THP-1 results in a protein kinase C-dependent secretion of tumor necrosis factor-alpha. Brain Research. 747: 114-21. PMID 9042534 DOI: 10.1016/S0006-8993(96)01229-2  0.318
1997 McGeer EG, McGeer PL. Inflammatory Cytokines in the CNS Cns Drugs. 7: 214-228. DOI: 10.2165/00023210-199707030-00005  0.329
1996 Matsuo A, Walker DG, Terai K, McGeer PL. Expression of CD43 in human microglia and its downregulation in Alzheimer's disease. Journal of Neuroimmunology. 71: 81-6. PMID 8982106 DOI: 10.1016/S0165-5728(96)00134-8  0.328
1996 Schwab C, Steele JC, McGeer PL. Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Research. 707: 196-205. PMID 8919296 DOI: 10.1016/0006-8993(95)01257-5  0.344
1996 Yasuhara O, Schwab C, Matsuo A, Kim SU, Steele JC, Akiguchi I, Kimura J, McGeer EG, McGeer PL. Midkine-like immunoreactivity in extracellular neurofibrillary tangles in brains of patients with parkinsonism-dementia complex of Guam. Neuroscience Letters. 205: 107-10. PMID 8907328 DOI: 10.1016/0304-3940(96)12385-5  0.368
1996 Rogers J, Webster S, Lue LF, Brachova L, Civin WH, Emmerling M, Shivers B, Walker D, McGeer P. Inflammation and Alzheimer's disease pathogenesis. Neurobiology of Aging. 17: 681-6. PMID 8892340 DOI: 10.1016/0197-4580(96)00115-7  0.353
1996 Schwab C, Steele JC, Akiyama H, McGeer PL. Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam. Acta Neuropathologica. 92: 378-85. PMID 8891070 DOI: 10.1007/S004010050533  0.346
1996 McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology. 47: 425-32. PMID 8757015 DOI: 10.1212/Wnl.47.2.425  0.311
1996 Yasuhara O, Akiguchi I, Nakamura S, Kinoshita A, Ikemoto A, Kawamoto Y, Kimura J, Funakoshi A, Tateishi K, McGeer PL. Pancreastatin-like immunoreactivity in globular dystrophic neurites of senile plaques in brains of patients with Alzheimer's disease. Neuroscience Letters. 208: 167-70. PMID 8733296 DOI: 10.1016/0304-3940(96)12573-8  0.373
1996 Jefferies WA, Food MR, Gabathuler R, Rothenberger S, Yamada T, Yasuhara O, McGeer PL. Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin. Brain Research. 712: 122-6. PMID 8705294 DOI: 10.1016/0006-8993(95)01407-1  0.343
1996 McGeer PL, McGeer EG. Anti-inflammatory drugs in the fight against Alzheimer's disease. Annals of the New York Academy of Sciences. 777: 213-20. PMID 8624086 DOI: 10.1111/J.1749-6632.1996.Tb34421.X  0.35
1996 McGeer P, Schulzer M, McGeer E. 807 Evidence supporting the inflammatory hypothesis of Alzheimer disease Neurobiology of Aging. 17: S201. DOI: 10.1016/S0197-4580(96)80809-8  0.328
1996 Takami K, Walker D, McGeer P. 71 Expression of presenilin-1 and -2 mRNAs in rat and Alzheimer brains Neurobiology of Aging. 17: S18. DOI: 10.1016/S0197-4580(96)80073-X  0.301
1995 McGeer PL, McGeer EG. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Research. Brain Research Reviews. 21: 195-218. PMID 8866675 DOI: 10.1016/0165-0173(95)00011-9  0.363
1995 Schwab C, Steele JC, Akiyama H, McGeer EG, McGeer PL. Relationship of amyloid beta/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia. Acta Neuropathologica. 90: 287-98. PMID 8525803 DOI: 10.1007/Bf00296513  0.355
1995 Yasuhara O, Matsuo A, Tooyama I, Kimura H, McGeer EG, McGeer PL. Pick's disease immunohistochemistry: new alterations and Alzheimer's disease comparisons. Acta Neuropathologica. 89: 322-30. PMID 7610763 DOI: 10.1007/Bf00309625  0.366
1994 Yasuhara O, Akiyama H, McGeer EG, McGeer PL. Immunohistochemical localization of hyaluronic acid in rat and human brain. Brain Research. 635: 269-82. PMID 8173963 DOI: 10.1016/0006-8993(94)91448-6  0.328
1994 Akiyama H, Tooyama I, Kondo H, Ikeda K, Kimura H, McGeer EG, McGeer PL. Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Research. 635: 257-68. PMID 8173962 DOI: 10.1016/0006-8993(94)91447-8  0.313
1994 Akiyama H, Ikeda K, Katoh M, McGeer EG, McGeer PL. Expression of MRP14, 27E10, interferon-alpha and leukocyte common antigen by reactive microglia in postmortem human brain tissue. Journal of Neuroimmunology. 50: 195-201. PMID 8120141 DOI: 10.1016/0165-5728(94)90046-9  0.348
1994 Yasuhara O, Kawamata T, Aimi Y, McGeer EG, McGeer PL. Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases. Neuroscience Letters. 171: 73-6. PMID 8084503 DOI: 10.1016/0304-3940(94)90608-4  0.323
1994 Yasuhara O, Aimi Y, McGeer EG, McGeer PL. Accumulation of amyloid precursor protein in brain lesions of patients with Pick disease. Neuroscience Letters. 171: 63-6. PMID 8084502 DOI: 10.1016/0304-3940(94)90605-X  0.346
1994 Yasuhara O, Kawamata T, Aimi Y, McGeer EG, McGeer PL. Expression of chromogranin A in lesions in the central nervous system from patients with neurological diseases. Neuroscience Letters. 170: 13-6. PMID 8041489 DOI: 10.1016/0304-3940(94)90227-5  0.359
1994 Moroo I, Yamada T, Makino H, Tooyama I, McGeer PL, McGeer EG, Hirayama K. Loss of insulin receptor immunoreactivity from the substantia nigra pars compacta neurons in Parkinson's disease. Acta Neuropathologica. 87: 343-8. PMID 8017169 DOI: 10.1007/Bf00313602  0.321
1994 Yasuhara O, Walker DG, McGeer PL. Hageman factor and its binding sites are present in senile plaques of Alzheimer's disease. Brain Research. 654: 234-40. PMID 7987673 DOI: 10.1016/0006-8993(94)90484-7  0.344
1994 McGeer PL, Rogers J, McGeer EG. Neuroimmune mechanisms in Alzheimer disease pathogenesis. Alzheimer Disease and Associated Disorders. 8: 149-58. PMID 7986484 DOI: 10.1097/00002093-199408030-00001  0.33
1994 Tooyama I, McGeer EG, Kawamata T, Kimura H, McGeer PL. Retention of basic fibroblast growth factor immunoreactivity in dopaminergic neurons of the substantia nigra during normal aging in humans contrasts with loss in Parkinson's disease. Brain Research. 656: 165-8. PMID 7804831 DOI: 10.1016/0006-8993(94)91378-1  0.309
1994 McGeer PL, Klegeris A, Walker DG, Yasuhara O, McGeer EG. Pathological proteins in senile plaques. The Tohoku Journal of Experimental Medicine. 174: 269-77. PMID 7761992 DOI: 10.1620/Tjem.174.269  0.33
1994 Yasuhara O, Aimi Y, McGeer EG, McGeer PL. Expression of the complement membrane attack complex and its inhibitors in Pick disease brain. Brain Research. 652: 346-9. PMID 7525023 DOI: 10.1016/0006-8993(94)90246-1  0.34
1993 McGeer PL, Kawamata T, Walker DG, Akiyama H, Tooyama I, McGeer EG. Microglia in degenerative neurological disease. Glia. 7: 84-92. PMID 8423066 DOI: 10.1002/Glia.440070114  0.355
1993 Tooyama I, Kremer HP, Hayden MR, Kimura H, McGeer EG, McGeer PL. Acidic and basic fibroblast growth factor-like immunoreactivity in the striatum and midbrain in Huntington's disease. Brain Research. 610: 1-7. PMID 7686078 DOI: 10.1016/0006-8993(93)91209-B  0.327
1992 Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, Civin WH, Brachova L, Bradt B, Ward P. Complement activation by beta-amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 89: 10016-20. PMID 1438191 DOI: 10.1073/Pnas.89.21.10016  0.322
1992 Walker DG, McGeer PL. Complement gene expression in human brain: comparison between normal and Alzheimer disease cases. Brain Research. Molecular Brain Research. 14: 109-16. PMID 1323007 DOI: 10.1016/0169-328X(92)90017-6  0.331
1992 Tooyama I, Yamada T, Kim SU, McGeer PL. Immunohistochemical study of A2B5-positive ganglioside in postmortem human brain tissue of Alzheimer disease, amyotrophic lateral sclerosis, progressive supranuclear palsy and control cases. Neuroscience Letters. 136: 91-4. PMID 1321969 DOI: 10.1016/0304-3940(92)90655-Q  0.329
1992 Yamada T, McGeer PL, McGeer EG. Some immunohistochemical features of argyrophilic grain dementia with normal cortical choline acetyltransferase levels but extensive subcortical pathology and markedly reduced dopamine. Journal of Geriatric Psychiatry and Neurology. 5: 3-13. PMID 1315137 DOI: 10.1177/002383099200500102  0.33
1992 Shigematsu K, McGeer PL, McGeer EG. Localization of amyloid precursor protein in selective postsynaptic densities of rat cortical neurons. Brain Research. 592: 353-7. PMID 1280522 DOI: 10.1016/0006-8993(92)91697-D  0.305
1991 Yamada T, McGeer PL, Baimbridge KG, McGeer EG. Relative sparing in Parkinson's disease of substantia nigra dopamine neurons containing calbindin-D28K. Brain Research. 526: 303-7. PMID 2257487 DOI: 10.1016/0006-8993(90)91236-A  0.315
1991 McGeer PL, Walker DG, Akiyama H, Kawamata T, Guan AL, Parker CJ, Okada N, McGeer EG. Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain. Brain Research. 544: 315-9. PMID 1710165 DOI: 10.1016/0006-8993(91)90071-3  0.355
1991 Yasuhara O, Tooyama I, Akiyama H, Akiguchi I, Kimura J, McGeer PL, Hara Y, Kimura H. Reactive Astrocytes Express Acidic Fibroblast Growth Factor in Alzheimer's Disease Brain Dementia and Geriatric Cognitive Disorders. 2: 64-70. DOI: 10.1159/000107178  0.346
1990 McGeer PL, McGeer EG. Cholinergic enzyme systems in Parkinson's disease. Archives of Neurology. 25: 265-8. PMID 4157296 DOI: 10.1001/Archneur.1971.00490030091011  0.332
1990 Akiyama H, Kaneko T, Mizuno N, McGeer PL. Distribution of phosphate-activated glutaminase in the human cerebral cortex Journal of Comparative Neurology. 297: 239-252. PMID 2196285 DOI: 10.1002/Cne.902970207  0.304
1990 Zhu SG, McGeer EG, McGeer PL. gamma-Glutamyltransferase activity is unchanged in acutely quinolinate-lesioned rat neostriatum but is elevated in Huntington's disease caudate. Experimental Neurology. 107: 106-9. PMID 1967236 DOI: 10.1016/0014-4886(90)90067-3  0.314
1989 McGeer PL, Itagaki S, Akiyama H, McGeer EG. Rate of cell death in parkinsonism indicates active neuropathological process. Annals of Neurology. 24: 574-6. PMID 3239957 DOI: 10.1002/Ana.410240415  0.321
1989 McGeer PL, Itagaki S, Tago H, McGeer EG. Occurrence of HLA-DR reactive microglia in Alzheimer's disease. Annals of the New York Academy of Sciences. 540: 319-23. PMID 3061340 DOI: 10.1111/J.1749-6632.1988.Tb27086.X  0.322
1989 McGeer EG, Singh EA, McGeer PL. Peripheral-type benzodiazepine binding in Alzheimer disease. Alzheimer Disease and Associated Disorders. 2: 331-6. PMID 2848549 DOI: 10.1097/00002093-198802040-00001  0.33
1989 Itagaki S, McGeer PL, Akiyama H, Zhu S, Selkoe D. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. Journal of Neuroimmunology. 24: 173-182. PMID 2808689 DOI: 10.1016/0165-5728(89)90115-X  0.324
1988 McGeer PL, McGeer EG, Itagaki S, Mizukawa K. Anatomy and pathology of the basal ganglia. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 14: 363-72. PMID 2890425 DOI: 10.1017/S0317167100037756  0.341
1987 McGeer PL, Itagaki S, Tago H, McGeer EG. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR. Neuroscience Letters. 79: 195-200. PMID 3670729 DOI: 10.1016/0304-3940(87)90696-3  0.31
1987 McGeer PL, McGeer EG, Kamo H, Wong K. Positron emission tomography and the possible origins of cytopathology in Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 10: 501-18. PMID 3541048 DOI: 10.1016/0278-5846(86)90021-7  0.336
1987 McGeer EG, Singh EA, McGeer PL. Sodium-dependent glutamate binding in senile dementia. Neurobiology of Aging. 8: 219-23. PMID 2885768 DOI: 10.1016/0197-4580(87)90005-4  0.307
1987 Beach TG, Tago H, Nagai T, Kimura H, McGeer PL, McGeer EG. Perfusion-fixation of the human brain for immunohistochemistry: comparison with immersion-fixation. Journal of Neuroscience Methods. 19: 183-92. PMID 2437408 DOI: 10.1016/S0165-0270(87)80001-8  0.307
1987 McGeer EG, Singh EA, McGeer PL. γ-GLUTAMYLTRANSFERASE Alzheimer Disease & Associated Disorders. 1: 38-42. DOI: 10.1097/00002093-198701000-00005  0.315
1986 McGeer E, McGeer PL. Possible destruction of cholinoceptive neurons by overstimulation of cholinergic tracts. Canadian Journal of Physiology and Pharmacology. 64: 363-8. PMID 2871914 DOI: 10.1139/Y86-059  0.305
1983 Nagai T, McGeer PL, Peng JH, McGeer EG, Dolman CE. Choline acetyltransferase immunohistochemistry in brains of Alzheimer's disease patients and controls. Neuroscience Letters. 36: 195-9. PMID 6866327 DOI: 10.1016/0304-3940(83)90264-1  0.35
1982 Wong PT, McGeer PL, Rossor M, McGeer EG. Ornithine aminotransferase in Huntington's disease. Brain Research. 231: 466-71. PMID 6459816 DOI: 10.1016/0006-8993(82)90385-7  0.329
1980 Kimura H, McGeer PL, Peng F, McGeer EG. Choline acetyltransferase-containing neurons in rodent brain demonstrated by immunohistochemistry. Science (New York, N.Y.). 208: 1057-9. PMID 6990490 DOI: 10.1126/Science.6990490  0.302
1971 McGeer PL, McGeer EG, Wada JA, Jung E. Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase. Brain Research. 32: 425-31. PMID 4944072 DOI: 10.1016/0006-8993(71)90334-9  0.306
1967 McGeer EG, Gibson S, McGeer PL. Some Characteristics Of Brain Tyrosine Hydroxylase Biochemistry and Cell Biology. 45: 53-68. DOI: 10.1007/978-1-4613-4574-9_4  0.308
1956 Rathmann GB, Curtis AJ, Mcgeer PL, Smyth CP. Microwave absorption and molecular structure in liquids. XIII. The critical wavelengths of some aliphatic ethers and long-chain ketones The Journal of Chemical Physics. 25: 413-416. DOI: 10.1063/1.1742936  0.712
1952 Curtis AJ, McGeer PL, Rathmann GB, Smyth CP. Microwave Absorption and Molecular Structure in Liquids. VII. Effects of Viscosity and Dipole—Dipole Forces1 Journal of the American Chemical Society. 74: 644-648. DOI: 10.1021/Ja01123A018  0.431
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