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Patrick L. McGeer, MD, University of British Columbia 1958,PhD,Princeton 1951, OC, OBC, FRSC, FRCP(C) - Publications

Medicine University of British Columbia, Vancouver, Vancouver, BC, Canada 

230 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lee M, McGeer EG, McGeer PL. Quercetin, not caffeine, is a major neuroprotective component in coffee. Neurobiology of Aging. 46: 113-123. PMID 27479153 DOI: 10.1016/j.neurobiolaging.2016.06.015  0.56
2016 Lee M, McGeer EG, McGeer PL. Sodium thiosulfate attenuates glial-mediated neuroinflammation in degenerative neurological diseases. Journal of Neuroinflammation. 13: 32. PMID 26856696 DOI: 10.1186/s12974-016-0488-8  0.56
2015 Hashioka S, McGeer PL, Miyaoka T, Wake R, Horiguchi J. Can inhibition of microglial activation cure schizophrenia? Schizophrenia Research. PMID 26254144 DOI: 10.1016/j.schres.2015.07.042  0.56
2015 Lee M, Wathier M, Love JA, McGeer E, McGeer PL. Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid. Neurobiology of Aging. PMID 26248865 DOI: 10.1016/j.neurobiolaging.2015.06.018  0.56
2015 Zhao T, Gao J, Van J, To E, Wang A, Cao S, Cui JZ, Guo JP, Lee M, McGeer PL, Matsubara JA. Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye. Journal of Neuroinflammation. 12: 121. PMID 26104676 DOI: 10.1186/s12974-015-0337-1  0.56
2015 Zhu A, Wu Z, Meng J, McGeer PL, Zhu Y, Nakanishi H, Wu S. The Neuroprotective Effects of Ratanasampil on Oxidative Stress-Mediated Neuronal Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity. 2015: 792342. PMID 26064424 DOI: 10.1155/2015/792342  0.56
2015 O'Hare E, Jeggo R, Kim EM, Barbour B, Walczak JS, Palmer P, Lyons T, Page D, Hanna D, Meara JR, Spanswick D, Guo JP, McGeer EG, McGeer PL, Hobson P. Lack of support for bexarotene as a treatment for Alzheimer's disease. Neuropharmacology. PMID 26025659 DOI: 10.1016/j.neuropharm.2015.04.020  0.56
2015 Hashioka S, McGeer EG, Miyaoka T, Wake R, Horiguchi J, McGeer PL. Interferon-γ-induced neurotoxicity of human astrocytes. Cns & Neurological Disorders Drug Targets. 14: 251-6. PMID 25687700  0.56
2015 Lee M, Shi X, Barron AE, McGeer E, McGeer PL. Human antimicrobial peptide LL-37 induces glial-mediated neuroinflammation. Biochemical Pharmacology. 94: 130-41. PMID 25686659 DOI: 10.1016/j.bcp.2015.02.003  0.56
2015 McGeer PL, McGeer EG. Targeting microglia for the treatment of Alzheimer's disease. Expert Opinion On Therapeutic Targets. 19: 497-506. PMID 25435348 DOI: 10.1517/14728222.2014.988707  0.56
2015 Lee M, McGeer E, McGeer PL. Activated human microglia stimulate neuroblastoma cells to upregulate production of beta amyloid protein and tau: implications for Alzheimer's disease pathogenesis. Neurobiology of Aging. 36: 42-52. PMID 25169677 DOI: 10.1016/j.neurobiolaging.2014.07.024  0.56
2014 Lee M, Narayanan S, McGeer EG, McGeer PL. Aurin tricarboxylic acid protects against red blood cell hemolysis in patients with paroxysmal nocturnal hemoglobinemia. Plos One. 9: e87316. PMID 24489894 DOI: 10.1371/journal.pone.0087316  0.56
2014 Hashioka S, Wang YF, Little JP, Choi HB, Klegeris A, McGeer PL, McLarnon JG. Purinergic responses of calcium-dependent signaling pathways in cultured adult human astrocytes. Bmc Neuroscience. 15: 18. PMID 24447580 DOI: 10.1186/1471-2202-15-18  0.56
2013 McGeer PL, McGeer EG. The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy. Acta Neuropathologica. 126: 479-97. PMID 24052108 DOI: 10.1007/s00401-013-1177-7  0.56
2013 Jantaratnotai N, Ling A, Cheng J, Schwab C, McGeer PL, McLarnon JG. Upregulation and expression patterns of the angiogenic transcription factor ets-1 in Alzheimer's disease brain. Journal of Alzheimer's Disease : Jad. 37: 367-77. PMID 23948889 DOI: 10.3233/JAD-122191  0.56
2013 Lee M, McGeer E, Kodela R, Kashfi K, McGeer PL. NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disorders. Glia. 61: 1724-34. PMID 23918470 DOI: 10.1002/glia.22553  0.56
2013 Wu Z, Sun L, Hashioka S, Yu S, Schwab C, Okada R, Hayashi Y, McGeer PL, Nakanishi H. Differential pathways for interleukin-1β production activated by chromogranin A and amyloid β in microglia. Neurobiology of Aging. 34: 2715-25. PMID 23831373 DOI: 10.1016/j.neurobiolaging.2013.05.018  0.56
2013 Lee M, Guo JP, McGeer EG, McGeer PL. Aurin tricarboxylic acid self-protects by inhibiting aberrant complement activation at the C3 convertase and C9 binding stages. Neurobiology of Aging. 34: 1451-61. PMID 23177218 DOI: 10.1016/j.neurobiolaging.2012.10.023  0.56
2013 Schwab C, Yu S, Wong W, McGeer EG, McGeer PL. GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 1073-88. PMID 23114513 DOI: 10.3233/JAD-2012-121330  0.56
2013 Lee M, McGeer E, McGeer PL. Neurotoxins released from interferon-gamma-stimulated human astrocytes. Neuroscience. 229: 164-75. PMID 23098801 DOI: 10.1016/j.neuroscience.2012.10.033  0.56
2012 Hashioka S, Klegeris A, McGeer PL. Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers. Neuropharmacology. 63: 685-91. PMID 22659089 DOI: 10.1016/j.neuropharm.2012.05.033  0.56
2012 Hashioka S, Klegeris A, McGeer PL. The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ. Journal of Neuroinflammation. 9: 113. PMID 22647614 DOI: 10.1186/1742-2094-9-113  0.56
2012 Jantaratnotai N, McGeer PL, McLarnon JG. Mechanisms of Mg2+ inhibition of BzATP-dependent Ca2+ responses in THP-1 monocytes. Brain Research. 1442: 1-8. PMID 22297175 DOI: 10.1016/j.brainres.2012.01.004  0.56
2012 Lee M, Guo JP, Schwab C, McGeer EG, McGeer PL. Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex. Neurobiology of Aging. 33: 2237-46. PMID 22217416 DOI: 10.1016/j.neurobiolaging.2011.12.005  0.56
2012 Schwab C, Yu S, McGeer PL. Optineurin is colocalized with ubiquitin in Marinesco bodies. Acta Neuropathologica. 123: 289-92. PMID 22101367 DOI: 10.1007/s00401-011-0915-y  0.56
2012 Schwab C, Yu S, McGeer EG, McGeer PL. Optineurin in Huntington's disease intranuclear inclusions. Neuroscience Letters. 506: 149-54. PMID 22085693 DOI: 10.1016/j.neulet.2011.10.070  0.56
2012 Lee M, Kwon BM, Kwon BM, Suk K, McGeer E, McGeer PL. Effects of obovatol on GSH depleted glia-mediated neurotoxicity and oxidative damage. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 173-86. PMID 21796424 DOI: 10.1007/s11481-011-9300-9  0.56
2012 Lee M, McGeer PL. Weak BMAA toxicity compares with that of the dietary supplement β-alanine. Neurobiology of Aging. 33: 1440-7. PMID 21236519 DOI: 10.1016/j.neurobiolaging.2010.11.024  0.56
2011 McGeer PL, McGeer EG. History of innate immunity in neurodegenerative disorders. Frontiers in Pharmacology. 2: 77. PMID 22144960 DOI: 10.3389/fphar.2011.00077  0.56
2011 Lee M, Kang Y, Suk K, Schwab C, Yu S, McGeer PL. Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein. The Journal of Biological Chemistry. 286: 41230-45. PMID 21990352 DOI: 10.1074/jbc.M111.270470  0.56
2011 Jantaratnotai N, Ryu JK, Schwab C, McGeer PL, McLarnon JG. Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain. International Journal of Alzheimer's Disease. 2011: 918280. PMID 21969915 DOI: 10.4061/2011/918280  0.56
2011 Lee M, McGeer EG, McGeer PL. Mechanisms of GABA release from human astrocytes. Glia. 59: 1600-11. PMID 21748804 DOI: 10.1002/glia.21202  0.56
2011 Lee M, Suk K, Kang Y, McGeer E, McGeer PL. Neurotoxic factors released by stimulated human monocytes and THP-1 cells. Brain Research. 1400: 99-111. PMID 21640980 DOI: 10.1016/j.brainres.2011.05.021  0.56
2011 McGeer PL, Steele JC. The ALS/PDC syndrome of Guam: potential biomarkers for an enigmatic disorder. Progress in Neurobiology. 95: 663-9. PMID 21527311 DOI: 10.1016/j.pneurobio.2011.04.001  0.56
2011 Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, et al. Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of Biological Chemistry. 286: 15095-105. PMID 21393248 DOI: 10.1074/jbc.M110.199356  0.56
2011 Hashioka S, Klegeris A, McGeer PL. Proton pump inhibitors reduce interferon-γ-induced neurotoxicity and STAT3 phosphorylation of human astrocytes. Glia. 59: 833-40. PMID 21360757 DOI: 10.1002/glia.21157  0.56
2011 Ryu JK, Jantaratnotai N, Serrano-Perez MC, McGeer PL, McLarnon JG. Block of purinergic P2X7R inhibits tumor growth in a C6 glioma brain tumor animal model. Journal of Neuropathology and Experimental Neurology. 70: 13-22. PMID 21157381 DOI: 10.1097/NEN.0b013e318201d4d4  0.56
2011 Lee M, Schwab C, McGeer PL. Astrocytes are GABAergic cells that modulate microglial activity. Glia. 59: 152-65. PMID 21046567 DOI: 10.1002/glia.21087  0.56
2011 Lee M, Jantaratnotai N, McGeer E, McLarnon JG, McGeer PL. Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels. Brain Research. 1369: 21-35. PMID 21040713 DOI: 10.1016/j.brainres.2010.10.084  0.56
2011 Hashioka S, Klegeris A, Qing H, McGeer PL. STAT3 inhibitors attenuate interferon-γ-induced neurotoxicity and inflammatory molecule production by human astrocytes. Neurobiology of Disease. 41: 299-307. PMID 20888416 DOI: 10.1016/j.nbd.2010.09.018  0.56
2010 Jantaratnotai N, Schwab C, Ryu JK, McGeer PL, McLarnon JG. Converging perturbed microvasculature and microglial clusters characterize Alzheimer disease brain. Current Alzheimer Research. 7: 625-36. PMID 20704556  0.56
2010 Hashioka S, Klegeris A, Schwab C, Yu S, McGeer PL. Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro. Journal of Neuroimmunology. 225: 91-9. PMID 20554027 DOI: 10.1016/j.jneuroim.2010.04.023  0.56
2010 Morawski M, Hartlage-Rübsamen M, Jäger C, Waniek A, Schilling S, Schwab C, McGeer PL, Arendt T, Demuth HU, Rossner S. Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease. Acta Neuropathologica. 120: 195-207. PMID 20383514 DOI: 10.1007/s00401-010-0685-y  0.56
2010 Lee M, Tazzari V, Giustarini D, Rossi R, Sparatore A, Del Soldato P, McGeer E, McGeer PL. Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease. The Journal of Biological Chemistry. 285: 17318-28. PMID 20368333 DOI: 10.1074/jbc.M110.115261  0.56
2010 Liu J, Shi M, Hong Z, Zhang J, Bradner J, Quinn T, Beyer RP, Mcgeer PL, Chen S, Zhang J. Identification of ciliary neurotrophic factor receptor alpha as a mediator of neurotoxicity induced by alpha-synuclein. Proteomics. 10: 2138-50. PMID 20340160 DOI: 10.1002/pmic.200900745  0.56
2010 Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL. Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2533-45. PMID 20228251 DOI: 10.1096/fj.09-149997  0.56
2010 Zou WQ, Langeveld J, Xiao X, Chen S, McGeer PL, Yuan J, Payne MC, Kang HE, McGeehan J, Sy MS, Greenspan NS, Kaplan D, Wang GX, Parchi P, Hoover E, et al. PrP conformational transitions alter species preference of a PrP-specific antibody. The Journal of Biological Chemistry. 285: 13874-84. PMID 20194495 DOI: 10.1074/jbc.M109.088831  0.56
2010 McGeer EG, McGeer PL. Neuroinflammation in Alzheimer's disease and mild cognitive impairment: a field in its infancy. Journal of Alzheimer's Disease : Jad. 19: 355-61. PMID 20061650 DOI: 10.3233/JAD-2010-1219  0.56
2010 Guo JP, Yu S, McGeer PL. Simple in vitro assays to identify amyloid-beta aggregation blockers for Alzheimer's disease therapy. Journal of Alzheimer's Disease : Jad. 19: 1359-70. PMID 20061605 DOI: 10.3233/JAD-2010-1331  0.56
2010 Schwab C, Klegeris A, McGeer PL. Inflammation in transgenic mouse models of neurodegenerative disorders. Biochimica Et Biophysica Acta. 1802: 889-902. PMID 19883753 DOI: 10.1016/j.bbadis.2009.10.013  0.56
2010 Lee M, Sparatore A, Del Soldato P, McGeer E, McGeer PL. Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation. Glia. 58: 103-13. PMID 19544392 DOI: 10.1002/glia.20905  0.56
2010 Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging. 31: 1503-15. PMID 18950899 DOI: 10.1016/j.neurobiolaging.2008.08.019  0.56
2010 Lee M, Del Soldato P, Sparatore A, McGeer P. Reply to Savolainen: High toxicity of hydrogen sulfide by the inhibition of mitochondrial respiration Journal of Biological Chemistry. 285: le10. DOI: 10.1074/jbc.N110.115261  0.56
2010 Zou WQ, Langeveld J, Xiao X, Chen S, McGeer PL, Yuan J, Payne MC, Kang HE, McGeehan J, Sy MS, Greenspan NS, Kaplan D, Wang GX, Parchi P, Hoover E, et al. Reply to Kascsak: Definition of the PrP 3F4 epitope revisited Journal of Biological Chemistry. 285: le6. DOI: 10.1074/jbc.N109.088831  0.56
2009 Hashioka S, McGeer PL, Monji A, Kanba S. Anti-inflammatory effects of antidepressants: possibilities for preventives against Alzheimer's disease. Central Nervous System Agents in Medicinal Chemistry. 9: 12-9. PMID 20021334 DOI: 10.2174/187152409787601897  0.56
2009 Qing H, Zhang Y, Deng Y, McGeer EG, McGeer PL. Lrrk2 interaction with alpha-synuclein in diffuse Lewy body disease. Biochemical and Biophysical Research Communications. 390: 1229-34. PMID 19878656 DOI: 10.1016/j.bbrc.2009.10.126  0.56
2009 Lee M, Schwab C, Yu S, McGeer E, McGeer PL. Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide. Neurobiology of Aging. 30: 1523-34. PMID 19631409 DOI: 10.1016/j.neurobiolaging.2009.06.001  0.56
2009 Qing H, Wong W, McGeer EG, McGeer PL. Lrrk2 phosphorylates alpha synuclein at serine 129: Parkinson disease implications. Biochemical and Biophysical Research Communications. 387: 149-52. PMID 19576176 DOI: 10.1016/j.bbrc.2009.06.142  0.56
2009 Ludolph AC, Kassubek J, Landwehrmeyer BG, Mandelkow E, Mandelkow EM, Burn DJ, Caparros-Lefebvre D, Frey KA, de Yebenes JG, Gasser T, Heutink P, Höglinger G, Jamrozik Z, Jellinger KA, Kazantsev A, ... ... McGeer PL, et al. Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 16: 297-309. PMID 19364361 DOI: 10.1111/j.1468-1331.2008.02513.x  0.56
2009 Schwab C, Arai T, Hasegawa M, Akiyama H, Yu S, McGeer PL. TDP-43 pathology in familial British dementia. Acta Neuropathologica. 118: 303-11. PMID 19283396 DOI: 10.1007/s00401-009-0514-3  0.56
2009 Hashioka S, Klegeris A, McGeer PL. Proton pump inhibitors exert anti-inflammatory effects and decrease human microglial and monocytic THP-1 cell neurotoxicity. Experimental Neurology. 217: 177-83. PMID 19232345 DOI: 10.1016/j.expneurol.2009.02.002  0.56
2009 Hashioka S, Klegeris A, Schwab C, McGeer PL. Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells. Neurobiology of Aging. 30: 1924-35. PMID 18375019 DOI: 10.1016/j.neurobiolaging.2008.02.019  0.56
2009 Hashioka S, McGeer PL. Complexity of microglial activation state: Can modifying microglial activation treat Alzheimer's disease? Future Neurology. 4: 137-139. DOI: 10.2217/14796708.4.2.137  0.56
2009 McGeer PL, McGeer EG, Schwab C. Inflammatory processes exacerbate degenerative neurological disorders Current Hypotheses and Research Milestones in Alzheimer's Disease. 117-124. DOI: 10.1007/978-0-387-87995-6_10  0.56
2008 Schwab C, Arai T, Hasegawa M, Yu S, McGeer PL. Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease. Journal of Neuropathology and Experimental Neurology. 67: 1159-65. PMID 19018245 DOI: 10.1097/NEN.0b013e31818e8951  0.56
2008 McGeer PL. Amyloid-beta vaccination for Alzheimer's dementia. Lancet. 372: 1381; author reply 1. PMID 18940458 DOI: 10.1016/S0140-6736(08)61579-2  0.56
2008 Miklossy J, Steele JC, Yu S, McCall S, Sandberg G, McGeer EG, McGeer PL. Enduring involvement of tau, beta-amyloid, alpha-synuclein, ubiquitin and TDP-43 pathology in the amyotrophic lateral sclerosis/parkinsonism-dementia complex of Guam (ALS/PDC). Acta Neuropathologica. 116: 625-37. PMID 18843496 DOI: 10.1007/s00401-008-0439-2  0.56
2008 Miklossy J, Kasas S, Zurn AD, McCall S, Yu S, McGeer PL. Persisting atypical and cystic forms of Borrelia burgdorferi and local inflammation in Lyme neuroborreliosis. Journal of Neuroinflammation. 5: 40. PMID 18817547 DOI: 10.1186/1742-2094-5-40  0.56
2008 Gnjec A, D'Costa KJ, Laws SM, Hedley R, Balakrishnan K, Taddei K, Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, ... ... McGeer PL, et al. Association of alleles carried at TNFA -850 and BAT1 -22 with Alzheimer's disease. Journal of Neuroinflammation. 5: 36. PMID 18715507 DOI: 10.1186/1742-2094-5-36  0.56
2008 Kamo H, Kiriyama Y, Mizoe A, Murase E, Okajima S, Akiguchi I, Hirasawa Y, McGeer PL. A computer support system for neurological anatomical diagnosis. Clinical Neurology and Neurosurgery. 110: 973-8. PMID 18621473 DOI: 10.1016/j.clineuro.2008.05.022  0.56
2008 Hashioka S, Miklossy J, Schwab C, Klegeris A, McGeer PL. Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain. Journal of Alzheimer's Disease : Jad. 14: 345-52. PMID 18599961  0.56
2008 Villoslada P, Moreno B, Melero I, Pablos JL, Martino G, Uccelli A, Montalban X, Avila J, Rivest S, Acarin L, Appel S, Khoury SJ, McGeer P, Ferrer I, Delgado M, et al. Immunotherapy for neurological diseases. Clinical Immunology (Orlando, Fla.). 128: 294-305. PMID 18534912 DOI: 10.1016/j.clim.2008.04.003  0.56
2008 McGeer PL, McGeer EG. The alpha-synuclein burden hypothesis of Parkinson disease and its relationship to Alzheimer disease. Experimental Neurology. 212: 235-8. PMID 18514193 DOI: 10.1016/j.expneurol.2008.04.008  0.56
2008 Steele JC, McGeer PL. The ALS/PDC syndrome of Guam and the cycad hypothesis. Neurology. 70: 1984-90. PMID 18490618 DOI: 10.1212/01.wnl.0000312571.81091.26  0.56
2008 Schwab C, McGeer PL. Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders. Journal of Alzheimer's Disease : Jad. 13: 359-69. PMID 18487845  0.56
2008 Winkler DF, McGeer PL. Protein labeling and biotinylation of peptides during spot synthesis using biotin p-nitrophenyl ester (biotin-ONp). Proteomics. 8: 961-7. PMID 18324722 DOI: 10.1002/pmic.200700909  0.56
2008 Klegeris A, Li J, Bammler TK, Jin J, Zhu D, Kashima DT, Pan S, Hashioka S, Maguire J, McGeer PL, Zhang J. Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity. Glia. 56: 675-85. PMID 18293395 DOI: 10.1002/glia.20645  0.56
2008 Yuan J, Dong Z, Guo JP, McGeehan J, Xiao X, Wang J, Cali I, McGeer PL, Cashman NR, Bessen R, Surewicz WK, Kneale G, Petersen RB, Gambetti P, Zou WQ. Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cellular and Molecular Life Sciences : Cmls. 65: 631-43. PMID 18193391 DOI: 10.1007/s00018-007-7478-z  0.56
2008 McGeer PL, McGeer EG. Glial reactions in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 474-83. PMID 18044695 DOI: 10.1002/mds.21751  0.56
2008 Klegeris A, Pelech S, Giasson BI, Maguire J, Zhang H, McGeer EG, McGeer PL. Alpha-synuclein activates stress signaling protein kinases in THP-1 cells and microglia. Neurobiology of Aging. 29: 739-52. PMID 17166628 DOI: 10.1016/j.neurobiolaging.2006.11.013  0.56
2008 McGeer PL. Preface Neuroimmune Pharmacology. vii-viii. DOI: 10.1007/978-0-387-72573-4  0.56
2007 McGeer EG, McGeer PL. The role of anti-inflammatory agents in Parkinson's disease. Cns Drugs. 21: 789-97. PMID 17850169 DOI: 10.2165/00023210-200721100-00001  0.56
2007 Miklossy J, Qing H, Guo JP, Yu S, Wszolek ZK, Calne D, McGeer EG, McGeer PL. Lrrk2 and chronic inflammation are linked to pallido-ponto-nigral degeneration caused by the N279K tau mutation. Acta Neuropathologica. 114: 243-54. PMID 17639429 DOI: 10.1007/s00401-007-0230-9  0.56
2007 Zhang W, Dallas S, Zhang D, Guo JP, Pang H, Wilson B, Miller DS, Chen B, Zhang W, McGeer PL, Hong JS, Zhang J. Microglial PHOX and Mac-1 are essential to the enhanced dopaminergic neurodegeneration elicited by A30P and A53T mutant alpha-synuclein. Glia. 55: 1178-88. PMID 17600340 DOI: 10.1002/glia.20532  0.56
2007 Klegeris A, Choi HB, McLarnon JG, McGeer PL. Functional ryanodine receptors are expressed by human microglia and THP-1 cells: Their possible involvement in modulation of neurotoxicity. Journal of Neuroscience Research. 85: 2207-15. PMID 17526017 DOI: 10.1002/jnr.21361  0.56
2007 Klegeris A, McGeer EG, McGeer PL. Therapeutic approaches to inflammation in neurodegenerative disease. Current Opinion in Neurology. 20: 351-7. PMID 17495632 DOI: 10.1097/WCO.0b013e3280adc943  0.56
2007 Hashioka S, Klegeris A, Monji A, Kato T, Sawada M, McGeer PL, Kanba S. Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide. Experimental Neurology. 206: 33-42. PMID 17481608 DOI: 10.1016/j.expneurol.2007.03.022  0.56
2007 Klegeris A, McGeer PL. Complement activation by islet amyloid polypeptide (IAPP) and alpha-synuclein 112. Biochemical and Biophysical Research Communications. 357: 1096-9. PMID 17459337 DOI: 10.1016/j.bbrc.2007.04.055  0.56
2007 Klegeris A, Schulzer M, Harper DG, McGeer PL. Increase in core body temperature of Alzheimer's disease patients as a possible indicator of chronic neuroinflammation: a meta-analysis. Gerontology. 53: 7-11. PMID 16940734 DOI: 10.1159/000095386  0.56
2007 McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: epidemiological, animal model and clinical studies. Neurobiology of Aging. 28: 639-47. PMID 16697488 DOI: 10.1016/j.neurobiolaging.2006.03.013  0.56
2007 McGeer EG, McGeer PL. Neuroinflammation, Alzheimer disease, and other aging disorders Pharmacological Mechanisms in Alzheimer's Therapeutics. 149-166. DOI: 10.1007/978-0-387-71522-3_10  0.56
2006 Miklossy J, Arai T, Guo JP, Klegeris A, Yu S, McGeer EG, McGeer PL. LRRK2 expression in normal and pathologic human brain and in human cell lines. Journal of Neuropathology and Experimental Neurology. 65: 953-63. PMID 17021400 DOI: 10.1097/01.jnen.0000235121.98052.54  0.56
2006 Klegeris A, Giasson BI, Zhang H, Maguire J, Pelech S, McGeer PL. Alpha-synuclein and its disease-causing mutants induce ICAM-1 and IL-6 in human astrocytes and astrocytoma cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2000-8. PMID 17012252 DOI: 10.1096/fj.06-6183com  0.56
2006 Wszolek ZK, Baba Y, Mackenzie IR, Uitti RJ, Strongosky AJ, Broderick DF, Baker MC, Melquist S, Hutton ML, Tsuboi Y, Allanson JE, Carr J, Kumar A, Calne SM, Miklossy J, ... McGeer PL, et al. Autosomal dominant dystonia-plus with cerebral calcifications. Neurology. 67: 620-5. PMID 16924015 DOI: 10.1212/01.wnl.0000230141.40784.09  0.56
2006 McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. Journal of Alzheimer's Disease : Jad. 9: 271-6. PMID 16914866  0.56
2006 Guo JP, Arai T, Miklossy J, McGeer PL. Abeta and tau form soluble complexes that may promote self aggregation of both into the insoluble forms observed in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 1953-8. PMID 16446437 DOI: 10.1073/pnas.0509386103  0.56
2006 Arai T, Miklossy J, Klegeris A, Guo JP, McGeer PL. Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain. Journal of Neuropathology and Experimental Neurology. 65: 19-25. PMID 16410745 DOI: 10.1097/01.jnen.0000196133.74087.cb  0.56
2006 Miklossy J, Doudet DD, Schwab C, Yu S, McGeer EG, McGeer PL. Role of ICAM-1 in persisting inflammation in Parkinson disease and MPTP monkeys. Experimental Neurology. 197: 275-83. PMID 16336966 DOI: 10.1016/j.expneurol.2005.10.034  0.56
2006 Patrick DM, Petric M, Skowronski DM, Guasparini R, Booth TF, Krajden M, McGeer P, Bastien N, Gustafson L, Dubord J, MacDonald D, David ST, Srour LF, Parker R, Andonov A, et al. An outbreak of human coronavirus OC43 infection and serological cross-reactivity with SARS coronavirus Canadian Journal of Infectious Diseases and Medical Microbiology. 17: 330-336.  0.56
2005 McGeer EG, McGeer PL. Abeta immunotherapy and other means to remove amyloid. Current Drug Targets. Cns and Neurological Disorders. 4: 569-73. PMID 16266289 DOI: 10.2174/156800705774322067  0.56
2005 McGeer EG, Klegeris A, McGeer PL. Inflammation, the complement system and the diseases of aging. Neurobiology of Aging. 26: 94-7. PMID 16198446 DOI: 10.1016/j.neurobiolaging.2005.08.008  0.56
2005 Klegeris A, McGeer PL. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Current Alzheimer Research. 2: 355-65. PMID 15974901 DOI: 10.2174/1567205054367883  0.56
2005 Miklossy J, Mackenzie IR, Dorovini-Zis K, Calne DB, Wszolek ZK, Klegeris A, McGeer PL. Severe vascular disturbance in a case of familial brain calcinosis. Acta Neuropathologica. 109: 643-53. PMID 15937691 DOI: 10.1007/s00401-005-1007-7  0.56
2005 McGeer PL, Sibley J. Sparing of age-related macular degeneration in rheumatoid arthritis. Neurobiology of Aging. 26: 1199-203. PMID 15917104 DOI: 10.1016/j.neurobiolaging.2005.02.003  0.56
2005 Klegeris A, McGeer PL. Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity. Glia. 51: 56-64. PMID 15779083 DOI: 10.1002/glia.20186  0.56
2005 Klegeris A, Bissonnette CJ, McGeer PL. Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system. Neurobiology of Aging. 26: 673-82. PMID 15708442 DOI: 10.1016/j.neurobiolaging.2004.06.012  0.56
2005 McGeer EG, McGeer PL. Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 19: 31-7. PMID 15691215 DOI: 10.2165/00063030-200519010-00004  0.56
2005 Stoessl AJ, McGeer PL. Hot spots: can positron emission tomography offer insights into the pathogenesis of PD? Annals of Neurology. 57: 161-2. PMID 15668974 DOI: 10.1002/ana.20382  0.56
2005 Arai T, Guo JP, McGeer PL. Proteolysis of non-phosphorylated and phosphorylated tau by thrombin. The Journal of Biological Chemistry. 280: 5145-53. PMID 15542598 DOI: 10.1074/jbc.M409234200  0.56
2004 McGeer PL, McGeer EG. Inflammation and the degenerative diseases of aging. Annals of the New York Academy of Sciences. 1035: 104-16. PMID 15681803 DOI: 10.1196/annals.1332.007  0.56
2004 Morris HR, Steele JC, Crook R, Wavrant-De Vrièze F, Onstead-Cardinale L, Gwinn-Hardy K, Wood NW, Farrer M, Lees AJ, McGeer PL, Siddique T, Hardy J, Perez-Tur J. Genome-wide analysis of the parkinsonism-dementia complex of Guam. Archives of Neurology. 61: 1889-97. PMID 15596609 DOI: 10.1001/archneur.61.12.1889  0.56
2004 Hosokawa M, Klegeris A, McGeer PL. Human oligodendroglial cells express low levels of C1 inhibitor and membrane cofactor protein mRNAs. Journal of Neuroinflammation. 1: 17. PMID 15327690 DOI: 10.1186/1742-2094-1-17  0.56
2004 McGeer PL, McGeer E. Immunotherapy for Alzheimer's disease. Science of Aging Knowledge Environment : Sage Ke. 2004: pe29. PMID 15243154 DOI: 10.1126/sageke.2004.27.pe29  0.56
2004 Klegeris A, Maguire J, McGeer PL. S- but not R-enantiomers of flurbiprofen and ibuprofen reduce human microglial and THP-1 cell neurotoxicity. Journal of Neuroimmunology. 152: 73-7. PMID 15223239 DOI: 10.1016/j.jneuroim.2004.04.001  0.56
2004 Guo JP, Petric M, Campbell W, McGeer PL. SARS corona virus peptides recognized by antibodies in the sera of convalescent cases. Virology. 324: 251-6. PMID 15207612 DOI: 10.1016/j.virol.2004.04.017  0.56
2004 Schwab C, Hosokawa M, McGeer PL. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease. Experimental Neurology. 188: 52-64. PMID 15191802 DOI: 10.1016/j.expneurol.2004.03.016  0.56
2004 Bissonnette CJ, Klegeris A, McGeer PL, McGeer EG. Interleukin 1alpha and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage. Neuroscience Letters. 361: 40-3. PMID 15135888 DOI: 10.1016/j.neulet.2004.01.005  0.56
2004 McGeer PL, McGeer EG. Inflammation and neurodegeneration in Parkinson's disease. Parkinsonism & Related Disorders. 10: S3-7. PMID 15109580 DOI: 10.1016/j.parkreldis.2004.01.005  0.56
2004 Akiyama H, McGeer PL. Specificity of mechanisms for plaque removal after A beta immunotherapy for Alzheimer disease. Nature Medicine. 10: 117-8; author reply . PMID 14760408 DOI: 10.1038/nm0204-117  0.56
2004 Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Schwab C, McGeer PL. Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. Acta Neuropathologica. 107: 53-8. PMID 14586629 DOI: 10.1007/s00401-003-0783-1  0.56
2004 Zhang XJ, McGeer PL. Correlation of complement receptor type 2 with senile plaque and neurofibrillar tangles in the hippocampal and temporal isocortex brain tissue in patients with Alzheimer disease Chinese Journal of Clinical Rehabilitation. 8: 6212-6214.  0.56
2003 McGeer PL, Schwab C, Parent A, Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Annals of Neurology. 54: 599-604. PMID 14595649 DOI: 10.1002/ana.10728  0.56
2003 McGeer EG, McGeer PL. Inflammatory processes in Alzheimer's disease. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 27: 741-9. PMID 12921904 DOI: 10.1016/S0278-5846(03)00124-6  0.56
2003 Schwab C, Hosokawa M, Akiyama H, McGeer PL. Familial British dementia: colocalization of furin and ABri amyloid. Acta Neuropathologica. 106: 278-84. PMID 12883829 DOI: 10.1007/s00401-003-0735-9  0.56
2003 McGeer EG, McGeer PL. Clinically tested drugs for Alzheimer's disease. Expert Opinion On Investigational Drugs. 12: 1143-51. PMID 12831349 DOI: 10.1517/13543784.12.7.1143  0.56
2003 Klegeris A, Bissonnette CJ, McGeer PL. Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. British Journal of Pharmacology. 139: 775-86. PMID 12813001 DOI: 10.1038/sj.bjp.0705304  0.56
2003 Hosokawa M, Klegeris A, Maguire J, McGeer PL. Expression of complement messenger RNAs and proteins by human oligodendroglial cells. Glia. 42: 417-23. PMID 12730962 DOI: 10.1002/glia.10234  0.56
2003 Klegeris A, McGeer PL. Toxicity of human monocytic THP-1 cells and microglia toward SH-SY5Y neuroblastoma cells is reduced by inhibitors of 5-lipoxygenase and its activating protein FLAP. Journal of Leukocyte Biology. 73: 369-78. PMID 12629151 DOI: 10.1189/jlb.1002482  0.56
2003 McGeer PL, McGeer E. Is there a future for vaccination as a treatment for Alzheimer's disease? Neurobiology of Aging. 24: 391-5. PMID 12600715 DOI: 10.1016/S0197-4580(02)00157-4  0.56
2002 McGeer PL, McGeer EG. Local neuroinflammation and the progression of Alzheimer's disease. Journal of Neurovirology. 8: 529-38. PMID 12476347 DOI: 10.1080/13550280290100969  0.56
2002 McGeer PL, McGeer EG. The possible role of complement activation in Alzheimer disease. Trends in Molecular Medicine. 8: 519-23. PMID 12421685 DOI: 10.1016/S1471-4914(02)02422-X  0.56
2002 Klegeris A, McGeer PL. Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity. Neurobiology of Aging. 23: 787-94. PMID 12392782 DOI: 10.1016/S0197-4580(02)00021-0  0.56
2002 McGeer PL, McGeer EG. Inflammatory processes in amyotrophic lateral sclerosis. Muscle & Nerve. 26: 459-70. PMID 12362410 DOI: 10.1002/mus.10191  0.56
2002 Morris HR, Baker M, Yasojima K, Houlden H, Khan MN, Wood NW, Hardy J, Grossman M, Trojanowski J, Revesz T, Bigio EH, Bergeron C, Janssen JC, McGeer PL, Rossor MN, et al. Analysis of tau haplotypes in Pick's disease. Neurology. 59: 443-5. PMID 12177383 DOI: 10.1212/WNL.59.3.443  0.56
2002 Klegeris A, Singh EA, McGeer PL. Effects of C-reactive protein and pentosan polysulphate on human complement activation. Immunology. 106: 381-8. PMID 12100726 DOI: 10.1046/j.1365-2567.2002.01425.x  0.56
2002 McGeer PL, McGeer EG, Yasojima K. Expression of COX-1 and COX-2 mRNAs in atherosclerotic plaques. Experimental Gerontology. 37: 925-9. PMID 12086701 DOI: 10.1016/S0531-5565(02)00028-1  0.56
2002 Klegeris A, Liutkevicius E, Mikalauskiene G, Duburs G, McGeer PL, Klusa V. Anti-inflammatory effects of cerebrocrast in a model of rat paw edema and on mononuclear THP-1 cells. European Journal of Pharmacology. 441: 203-8. PMID 12063093 DOI: 10.1016/S0014-2999(02)01262-1  0.56
2002 McGeer PL, Yasojima K, McGeer EG. Association of interleukin-1 beta polymorphisms with idiopathic Parkinson's disease. Neuroscience Letters. 326: 67-9. PMID 12052540 DOI: 10.1016/S0304-3940(02)00300-2  0.56
2002 Schwab C, McGeer PL. Complement activated C4d immunoreactive oligodendrocytes delineate small cortical plaques in multiple sclerosis. Experimental Neurology. 174: 81-8. PMID 11869036 DOI: 10.1006/exnr.2001.7851  0.56
2002 Wakita H, Tomimoto H, Akiguchi I, Matsuo A, Lin JX, Ihara M, McGeer PL. Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat. Brain Research. 924: 63-70. PMID 11743996 DOI: 10.1016/S0006-8993(01)03223-1  0.56
2001 McGeer EG, McGeer PL. Chronic inflammation in Alzheimer's disease offers therapeutic opportunities. Expert Review of Neurotherapeutics. 1: 53-60. PMID 19811046 DOI: 10.1586/14737175.1.1.53  0.56
2001 McGeer EG, McGeer PL. Innate immunity in Alzheimer's disease: a model for local inflammatory reactions. Molecular Interventions. 1: 22-9. PMID 14993335  0.56
2001 McGeer PL. COX-2 and ALS. Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases. 2: 121-2. PMID 11771766 DOI: 10.1080/146608201753275562  0.56
2001 McGeer EG, Yasojima K, Schwab C, McGeer PL. The pentraxins: possible role in Alzheimer's disease and other innate inflammatory diseases. Neurobiology of Aging. 22: 843-8. PMID 11754991 DOI: 10.1016/S0197-4580(01)00288-3  0.56
2001 McGeer PL, McGeer EG. Inflammation, autotoxicity and Alzheimer disease. Neurobiology of Aging. 22: 799-809. PMID 11754986 DOI: 10.1016/S0197-4580(01)00289-5  0.56
2001 Burnakis TG, Fleming M, Konstam MA, Demopoulos LA, Grant KD, Haldey EJ, Pappagallo M, Minic M, McGeer PL, McGeer EG, Yasojima K, Singh G, White WB, Whelton A, Mukherjee D, et al. Cardiovascular events and COX-2 inhibitors [1] (multiple letters) Journal of the American Medical Association. 286: 2808-2813. PMID 11735741  0.56
2001 Yasojima K, McGeer EG, McGeer PL. High stability of mRNAs postmortem and protocols for their assessment by RT-PCR. Brain Research. Brain Research Protocols. 8: 212-8. PMID 11733198 DOI: 10.1016/S1385-299X(01)00119-2  0.56
2001 McGeer PL, McGeer EG. Polymorphisms in inflammatory genes and the risk of Alzheimer disease. Archives of Neurology. 58: 1790-2. PMID 11708985  0.56
2001 Yasojima K, McGeer EG, McGeer PL. Relationship between beta amyloid peptide generating molecules and neprilysin in Alzheimer disease and normal brain. Brain Research. 919: 115-21. PMID 11689168 DOI: 10.1016/S0006-8993(01)03008-6  0.56
2001 Klegeris A, McGeer PL. Inflammatory cytokine levels are influenced by interactions between THP-1 monocytic, U-373 MG astrocytic, and SH-SY5Y neuronal cell lines of human origin. Neuroscience Letters. 313: 41-4. PMID 11684335 DOI: 10.1016/S0304-3940(01)02251-0  0.56
2001 Morris HR, Al-Sarraj S, Schwab C, Gwinn-Hardy K, Perez-Tur J, Wood NW, Hardy J, Lees AJ, McGeer PL, Daniel SE, Steele JC. A clinical and pathological study of motor neurone disease on Guam. Brain : a Journal of Neurology. 124: 2215-22. PMID 11673323  0.56
2001 Yasojima K, McGeer EG, McGeer PL. 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA in Alzheimer and control brain. Neuroreport. 12: 2935-8. PMID 11588606  0.56
2001 Yasojima K, Tourtellotte WW, McGeer EG, McGeer PL. Marked increase in cyclooxygenase-2 in ALS spinal cord: implications for therapy. Neurology. 57: 952-6. PMID 11571316 DOI: 10.1212/WNL.57.6.952  0.56
2001 McGeer PL, Yasojima K, McGeer EG. Inflammation in Parkinson's disease. Advances in Neurology. 86: 83-9. PMID 11554012  0.56
2001 Yasojima K, Schwab C, McGeer EG, McGeer PL. Complement components, but not complement inhibitors, are upregulated in atherosclerotic plaques. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1214-9. PMID 11451754  0.56
2001 Klegeris A, Schwab C, Bissonnette CJ, McGeer PL. Induction of complement C9 messenger RNAs in human neuronal cells by inflammatory stimuli: relevance to neurodegenerative disorders. Experimental Gerontology. 36: 1179-88. PMID 11404058 DOI: 10.1016/S0531-5565(00)00265-5  0.56
2001 Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL. Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein (Abeta) deposition. Brain Research. 902: 277-81. PMID 11384622 DOI: 10.1016/S0006-8993(01)02390-3  0.56
2001 Arai T, Ikeda K, Akiyama H, Shikamoto Y, Tsuchiya K, Yagishita S, Beach T, Rogers J, Schwab C, McGeer PL. Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathologica. 101: 167-73. PMID 11271372  0.56
2001 Yasojima K, Schwab C, McGeer EG, McGeer PL. Generation of C-reactive protein and complement components in atherosclerotic plaques. The American Journal of Pathology. 158: 1039-51. PMID 11238052 DOI: 10.1016/S0002-9440(10)64051-5  0.56
2001 Yasojima K, Akiyama H, McGeer EG, McGeer PL. Reduced neprilysin in high plaque areas of Alzheimer brain: a possible relationship to deficient degradation of beta-amyloid peptide. Neuroscience Letters. 297: 97-100. PMID 11121879 DOI: 10.1016/S0304-3940(00)01675-X  0.56
2001 McGeer PL. NeuroScience News: Editorial Neuroscience News. 4: 3.  0.56
2000 Yasojima K, Schwab C, McGeer EG, McGeer PL. Human neurons generate C-reactive protein and amyloid P: upregulation in Alzheimer's disease. Brain Research. 887: 80-9. PMID 11134592 DOI: 10.1016/S0006-8993(00)02970-X  0.56
2000 Klegeris A, McGeer PL. R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition. Experimental Neurology. 166: 458-64. PMID 11085911 DOI: 10.1006/exnr.2000.7517  0.56
2000 Lee CY, Ho J, Chow SN, Yasojima K, Schwab C, McGeer PL. Immunoidentification of gonadotropin releasing hormone receptor in human sperm, pituitary and cancer cells. American Journal of Reproductive Immunology (New York, N.Y. : 1989). 44: 170-7. PMID 11028904  0.56
2000 Tanhehco EJ, Yasojima K, McGeer PL, McGeer EG, Lucchesi BR. Preconditioning reduces myocardial complement gene expression in vivo. American Journal of Physiology. Heart and Circulatory Physiology. 279: H1157-65. PMID 10993779  0.56
2000 McGeer PL, McGeer EG, Yasojima K. Alzheimer disease and neuroinflammation. Journal of Neural Transmission. Supplementum. 59: 53-7. PMID 10961418  0.56
2000 McGeer PL. Cyclo-oxygenase-2 inhibitors: rationale and therapeutic potential for Alzheimer's disease. Drugs & Aging. 17: 1-11. PMID 10933512  0.56
2000 Schwab C, DeMaggio AJ, Ghoshal N, Binder LI, Kuret J, McGeer PL. Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseases. Neurobiology of Aging. 21: 503-10. PMID 10924763 DOI: 10.1016/S0197-4580(00)00110-X  0.56
2000 Tanhehco EJ, Yasojima K, McGeer PL, Washington RA, Lucchesi BR. Free radicals upregulate complement expression in rabbit isolated heart. American Journal of Physiology. Heart and Circulatory Physiology. 279: H195-201. PMID 10899056  0.56
2000 Klegeris A, Bissonnette CJ, Dorovini-Zis K, McGeer PL. Expression of complement messenger RNAs by human endothelial cells. Brain Research. 871: 1-6. PMID 10882776 DOI: 10.1016/S0006-8993(00)02253-8  0.56
2000 McGeer PL, McGeer EG. Autotoxicity and Alzheimer disease. Archives of Neurology. 57: 789-90. PMID 10867774  0.56
2000 Cooper NR, Kalaria RN, McGeer PL, Rogers J. Key issues in Alzheimer's disease inflammation. Neurobiology of Aging. 21: 451-453. PMID 10858594 DOI: 10.1016/S0197-4580(00)00148-2  0.56
2000 Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, ... ... McGeer PL, et al. Inflammation and Alzheimer's disease. Neurobiology of Aging. 21: 383-421. PMID 10858586 DOI: 10.1016/S0197-4580(00)00124-X  0.56
2000 Yasojima K, Kuret J, DeMaggio AJ, McGeer E, McGeer PL. Casein kinase 1 delta mRNA is upregulated in Alzheimer disease brain. Brain Research. 865: 116-20. PMID 10814741 DOI: 10.1016/S0006-8993(00)02200-9  0.56
2000 Klegeris A, McGeer EG, McGeer PL. Inhibitory action of 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxam ide (PK 11195) on some mononuclear phagocyte functions. Biochemical Pharmacology. 59: 1305-14. PMID 10736431 DOI: 10.1016/S0006-2952(00)00252-5  0.56
2000 Schwab C, McGeer PL. Abeta42-carboxy-terminal-like immunoreactivity is associated with intracellular neurofibrillary tangles and pick bodies. Experimental Neurology. 161: 527-34. PMID 10686074 DOI: 10.1006/exnr.1999.7307  0.56
2000 Klegeris A, McGeer PL. Interaction of various intracellular signaling mechanisms involved in mononuclear phagocyte toxicity toward neuronal cells. Journal of Leukocyte Biology. 67: 127-33. PMID 10648007  0.56
2000 Nakagawa E, Aimi Y, Yasuhara O, Tooyama I, Shimada M, McGeer PL, Kimura H. Enhancement of progenitor cell division in the dentate gyrus triggered by initial limbic seizures in rat models of epilepsy. Epilepsia. 41: 10-8. PMID 10643917  0.56
2000 Tanhehco EJ, Yasojima K, McGeer PL, Lucchesi BR. Acute cocaine exposure up-regulates complement expression in rabbit heart. The Journal of Pharmacology and Experimental Therapeutics. 292: 201-8. PMID 10604949  0.56
2000 McGeer PL. Dissolving dogmas and pillars of pessimism Neuroscience News. 3: 1.  0.56
2000 McGeer PL. Muscular dystrophy: Unfolding a medical promise Neuroscience News. 3: 1.  0.56
2000 McGeer PL. HD, RFLP and a revolution in the approach to inherited diseases: Editorial Neuroscience News. 3: 5.  0.56
2000 Giacobini E, McGeer PL. Approaches to the treatment of Alzheimer's disease Neuroscience News. 3: 62-70.  0.56
1999 Tanhehco EJ, Yasojima K, McGeer PL, Washington RA, Kilgore KS, Homeister JW, Lucchesi BR. Preconditioning reduces tissue complement gene expression in the rabbit isolated heart. The American Journal of Physiology. 277: H2373-80. PMID 10600858  0.56
1999 Waterfield JD, McGeer EG, McGeer PL. The peripheral benzodiazepine receptor ligand PK 11195 inhibits arthritis in the MRL-lpr mouse model. Rheumatology (Oxford, England). 38: 1068-73. PMID 10556257  0.56
1999 Steele JC, Morris HR, Lees AJ, Perez-Tur J, McGeer PL. Atypical parkinsonism in the French West Indies. Lancet. 354: 1474. PMID 10543696 DOI: 10.1016/S0140-6736(05)77614-5  0.56
1999 Litvan I, Caparros-Lefebvre D, Lees A, Collins MA, Steele JC, Morris HR, Lees AJ, Perez-Tur J, McGeer PL. Atypical parkinsonism in the French West Indies (multiple letters) [4] Lancet. 354: 1472-1474. PMID 10543694  0.56
1999 McGeer EG, McGeer PL. Brain inflammation in Alzheimer disease and the therapeutic implications. Current Pharmaceutical Design. 5: 821-36. PMID 10526088  0.56
1999 Schwab C, Schulzer M, Steele JC, McGeer PL. On the survival time of a tangled neuron in the hippocampal CA4 region in parkinsonism dementia complex of Guam. Neurobiology of Aging. 20: 57-63. PMID 10466894 DOI: 10.1016/S0197-4580(99)00005-6  0.56
1999 Pérez-Tur J, Buée L, Morris HR, Waring SC, Onstead L, Wavrant-De Vrièze F, Crook R, Buée-Scherrer V, Hof PR, Petersen RC, McGeer PL, Delacourte A, Hutton M, Siddique T, Ahlskog JE, et al. Neurodegenerative diseases of Guam: analysis of TAU. Neurology. 53: 411-3. PMID 10430438 DOI: 10.1212/WNL.53.2.411  0.56
1999 Akiyama H, Mori H, Saido T, Kondo H, Ikeda K, McGeer PL. Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia. 25: 324-31. PMID 10028915 DOI: 10.1002/(SICI)1098-1136(19990215)25:4<324::AID-GLIA2>3.0.CO;2-5  0.56
1999 McGeer PL, McGeer EG. Parkinson's disease and the dawn of contemporary neuroscience Neuroscience News. 2: 15-18.  0.56
1998 Schwab C, Steele JC, McGeer PL. Pyramidal neuron loss is matched by ghost tangle increase in Guam parkinsonism-dementia hippocampus. Acta Neuropathologica. 96: 409-16. PMID 9797006 DOI: 10.1007/s004010050912  0.56
1998 Walker DG, McGeer PL. Vitronectin expression in Purkinje cells in the human cerebellum. Neuroscience Letters. 251: 109-12. PMID 9718986 DOI: 10.1016/S0304-3940(98)00517-5  0.56
1997 Schwab C, Steele JC, McGeer PL. Dystrophic neurites are associated with early stage extracellular neurofibrillary tangles in the parkinsonism-dementia complex of Guam. Acta Neuropathologica. 94: 486-92. PMID 9386782 DOI: 10.1007/s004010050737  0.56
1997 Webster S, Lue LF, Brachova L, Tenner AJ, McGeer PL, Terai K, Walker DG, Bradt B, Cooper NR, Rogers J. Molecular and cellular characterization of the membrane attack complex, C5b-9, in Alzheimer's disease. Neurobiology of Aging. 18: 415-21. PMID 9330973 DOI: 10.1016/S0197-4580(97)00042-0  0.56
1997 McGeer PL, Schwab C, McGeer EG, Haddock RL, Steele JC. Familial nature and continuing morbidity of the amyotrophic lateral sclerosis-parkinsonism dementia complex of Guam. Neurology. 49: 400-9. PMID 9270568  0.56
1997 Yasuhara O, Matsuo A, Terai K, Walker DG, Berger AE, Akiguchi I, Kimura J, McGeer PL. Expression of interleukin-1 receptor antagonist protein in post-mortem human brain tissues of Alzheimer's disease and control cases. Acta Neuropathologica. 93: 414-20. PMID 9113207 DOI: 10.1007/s004010050633  0.56
1997 Matsuo A, Lee GC, Terai K, Takami K, Hickey WF, McGeer EG, McGeer PL. Unmasking of an unusual myelin basic protein epitope during the process of myelin degeneration in humans: a potential mechanism for the generation of autoantigens. The American Journal of Pathology. 150: 1253-66. PMID 9094982  0.56
1997 Schwab C, Steele JC, McGeer EG, McGeer PL. Amyloid P immunoreactivity precedes C4d deposition on extracellular neurofibrillary tangles. Acta Neuropathologica. 93: 87-92. PMID 9006661  0.56
1996 Schwab C, Steele JC, McGeer PL. Neurofibrillary tangles of Guam parkinson-dementia are associated with reactive microglia and complement proteins. Brain Research. 707: 196-205. PMID 8919296 DOI: 10.1016/0006-8993(95)01257-5  0.56
1996 Schwab C, Steele JC, Akiyama H, McGeer PL. Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam. Acta Neuropathologica. 92: 378-85. PMID 8891070 DOI: 10.1007/s004010050533  0.56
1996 Yasuhara O, Akiguchi I, Nakamura S, Kinoshita A, Ikemoto A, Kawamoto Y, Kimura J, Funakoshi A, Tateishi K, McGeer PL. Pancreastatin-like immunoreactivity in globular dystrophic neurites of senile plaques in brains of patients with Alzheimer's disease. Neuroscience Letters. 208: 167-70. PMID 8733296 DOI: 10.1016/0304-3940(96)12573-8  0.56
1995 Schwab C, Steele JC, Akiyama H, McGeer EG, McGeer PL. Relationship of amyloid beta/A4 protein to the neurofibrillary tangles in Guamanian parkinsonism-dementia. Acta Neuropathologica. 90: 287-98. PMID 8525803 DOI: 10.1007/BF00296513  0.56
1995 Oken RJ, McGeer PL. Schizophrenia: a 100-year retrospective. The American Journal of Psychiatry. 152: 1692-3; author reply. PMID 7485645  0.56
1993 Rogers J, Kirby LC, Hempelman SR, Berry DL, McGeer PL, Kaszniak AW, Zalinski J, Cofield M, Mansukhani L, Willson P. Clinical trial of indomethacin in Alzheimer's disease. Neurology. 43: 1609-11. PMID 8351023  0.56
1993 Walker DG, McGeer PL. Complement gene expression in neuroblastoma and astrocytoma cell lines of human origin. Neuroscience Letters. 157: 99-102. PMID 8233040 DOI: 10.1016/0304-3940(93)90652-2  0.56
1992 Rogers J, Cooper NR, Webster S, Schultz J, McGeer PL, Styren SD, Civin WH, Brachova L, Bradt B, Ward P. Complement activation by beta-amyloid in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 89: 10016-20. PMID 1438191  0.56
1992 Boyes BE, Walker DG, McGeer PL, McGeer EG. Identification and characterization of a large human brain gene whose expression is increased in Alzheimer disease. Brain Research. Molecular Brain Research. 12: 47-57. PMID 1372073 DOI: 10.1016/0169-328X(92)90067-L  0.56
1992 Walker DG, McGeer PL. Complement gene expression in human brain: comparison between normal and Alzheimer disease cases. Brain Research. Molecular Brain Research. 14: 109-16. PMID 1323007 DOI: 10.1016/0169-328X(92)90017-6  0.56
1990 McGeer EG, Peppard RP, McGeer PL, Tuokko H, Crockett D, Parks R, Akiyama H, Calne DB, Beattie BL, Harrop R. 18Fluorodeoxyglucose Positron Emission Tomography Studies in Presumed Alzheimer Cases, Including 13 Serial Scans Canadian Journal of Neurological Sciences / Journal Canadien Des Sciences Neurologiques. 17: 1-11. PMID 2311010 DOI: 10.1017/S0317167100029930  0.56
1990 Akiyama H, Kaneko T, Mizuno N, McGeer PL. Distribution of phosphate-activated glutaminase in the human cerebral cortex Journal of Comparative Neurology. 297: 239-252. PMID 2196285 DOI: 10.1002/cne.902970207  0.56
1989 Mizukawa K, Vincent SR, McGeer PL, McGeer EG. Distribution of reduced-nicotinamide-adenine-dinucleotide-phosphate diaphorase-positive cells and fibers in the cat central nervous system. The Journal of Comparative Neurology. 279: 281-311. PMID 2913070 DOI: 10.1002/cne.902790210  0.56
1989 Walker DG, O'Kusky JR, McGeer PL. In situ hybridization analysis for herpes simplex virus nucleic acids in Alzheimer disease. Alzheimer Disease and Associated Disorders. 3: 123-31. PMID 2551348 DOI: 10.1097/00002093-198903030-00001  0.56
1989 Parks RW, Crockett DJ, Tuokko H, Beattie BL, Ashford JW, Coburn KL, Zec RF, Becker RE, McGeer PL, McGeer EG. Neuropsychological "systems efficiency" and positron emission tomography. The Journal of Neuropsychiatry and Clinical Neurosciences. 1: 269-82. PMID 2521071 DOI: 10.1176/jnp.1.3.269  0.56
1989 Walker DG, Boyes BE, McGeer PL, McGeer EG. Strategies for the identification of novel brain specific genes affected in Alzheimer disease. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 16: 483-9. PMID 2509057 DOI: 10.1017/S0317167100029814  0.56
1988 Mizukawa K, McGeer PL, Vincent SR, McGeer EG. Ultrastructure of reduced nicotinamide adenine dinucleotide phosphate (NADPH) diaphorase-positive neurons in the cat cerebral cortex, amygdala and caudate nucleus. Brain Research. 452: 286-92. PMID 3401736 DOI: 10.1016/0006-8993(88)90032-7  0.56
1988 McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology. 38: 1285-91. PMID 3399080 DOI: 10.1212/WNL.38.8.1285  0.56
1988 Mizukawa K, Vincent SR, McGeer PL, McGeer EG. Reduced nicotinamide adenine dinucleotide phosphate (NADPH)-diaphorase-positive neurons in cat cerebral white matter. Brain Research. 461: 274-81. PMID 3179718 DOI: 10.1016/0006-8993(88)90257-0  0.56
1988 Mizukawa K, Otsuka N, McGeer PL, Vincent SR, McGeer EG. The ultrastructure of somatostatin-immunoreactive cell bodies, nerve fibers and terminals in the dorsal horn of rat spinal cord. Archives of Histology and Cytology. 51: 443-52. PMID 2906234 DOI: 10.1679/AOHC.51.443  0.56
1988 Boyes BE, Walker DG, McGeer PL. Separation of large DNA restriction fragments on a size-exclusion column by a nonideal mechanism. Analytical Biochemistry. 170: 127-34. PMID 2839050 DOI: 10.1016/0003-2697(88)90099-1  0.56
1987 Mizukawa K, McGeer PL, Vincent SR, McGeer EG. The distribution of somatostatin-immunoreactive neurons and fibers in the rat cerebral cortex: light and electron microscopic studies. Brain Research. 426: 28-36. PMID 2891408 DOI: 10.1016/0006-8993(87)90421-5  0.56
1985 McGeer EG, Norman M, Boyes B, O'Kusky J, Suzuki J, McGeer PL. Acetylcholine and aromatic amine systems in postmortem brain of an infant with Down's syndrome Experimental Neurology. 87: 557-570. PMID 2857653 DOI: 10.1016/0014-4886(85)90184-0  0.56
1982 Brownell GL, Budinger TF, Lauterbur PC, McGeer PL. Positron tomography and nuclear magnetic resonance imaging. Science (New York, N.Y.). 215: 619-26. PMID 17842371 DOI: 10.1126/science.215.4533.619  0.56
1972 MacFadyen DJ, Picton TW, Zeldowicz L, McGeer PL. Amantadine-HCl in the treatment of Parkinson's disease: a controlled trial. The Journal of Clinical Pharmacology and New Drugs. 12: 274-9. PMID 4483534  0.56
1971 McGeer PL, McGeer EG, Wada JA. Glutamic acid decarboxylase in Parkinson's disease and epilepsy. Neurology. 21: 1000-7. PMID 5165300  0.56
1971 McGeer EG, McGeer PL, Wada JA. Distribution of tyrosine hydroxylase in human and animal brain. Journal of Neurochemistry. 18: 1647-58. PMID 4998978  0.56
1971 McGeer PL, McGeer EG, Wada JA, Jung E. Effects of globus pallidus lesions and Parkinson's disease on brain glutamic acid decarboxylase. Brain Research. 32: 425-31. PMID 4944072 DOI: 10.1016/0006-8993(71)90334-9  0.56
1967 McGeer EG, Gibson S, Wada JA, McGeer PL. Distribution of tyrosine hydroxylase activity in adult and developing brain. Canadian Journal of Biochemistry. 45: 1943-52. PMID 6082577  0.56
1956 Rathmann GB, Curtis AJ, Mcgeer PL, Smyth CP. Microwave absorption and molecular structure in liquids. XIII. The critical wavelengths of some aliphatic ethers and long-chain ketones The Journal of Chemical Physics. 25: 413-416. DOI: 10.1063/1.1742936  0.56
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