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Christian Haass, PhD, University of Heidelberg 1989 - Publications

Biochemistry Ludwig-Maximilians-Universität München, München, Bayern, Germany 

314 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F. γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics. The Embo Journal. e104247. PMID 32830336 DOI: 10.15252/embj.2019104247  0.6
2020 Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, ... ... Haass C, et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/emmm.202012308  0.36
2020 Palleis C, Morenas-Rodriguez E, Murcia FJM, Giese A, Nuscher B, Haass C, Höglinger G, Bötzel K, Levin J. Longitudinal correlation between neurofilament light chain and UMSARS in Multiple System Atrophy. Clinical Neurology and Neurosurgery. 195: 105924. PMID 32512475 DOI: 10.1016/j.clineuro.2020.105924  0.36
2020 Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 9. PMID 32510331 DOI: 10.7554/eLife.54083  0.44
2020 Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C. Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32237095 DOI: 10.1096/fj.201902183R  0.36
2020 Lüningschrör P, Werner G, Stroobants S, Kakuta S, Dombert B, Sinske D, Wanner R, Lüllmann-Rauch R, Wefers B, Wurst W, D'Hooge R, Uchiyama Y, Sendtner M, Haass C, Saftig P, et al. The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons. Cell Reports. 30: 3506-3519.e6. PMID 32160553 DOI: 10.1016/j.celrep.2020.02.060  0.48
2020 Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, ... ... Haass C, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. Embo Molecular Medicine. e11227. PMID 32154671 DOI: 10.15252/emmm.201911227  0.36
2019 Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, et al. Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. Embo Molecular Medicine. e10919. PMID 31858749 DOI: 10.15252/emmm.201910919  0.4
2019 Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M, Kamp F, Nuscher B, Edbauer D, ... Haass C, et al. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. Acta Neuropathologica. PMID 31642962 DOI: 10.1007/s00401-019-02082-0  0.4
2019 Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J. Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects. Neurobiology of Aging. PMID 31627977 DOI: 10.1016/j.neurobiolaging.2019.08.034  0.6
2019 Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/scitranslmed.aav6221  0.36
2019 Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, ... ... Haass C, et al. The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11. PMID 31413141 DOI: 10.1126/scitranslmed.aau2291  0.36
2019 Morenas-Rodríguez E, Alcolea D, Suárez-Calvet M, Muñoz-Llahuna L, Vilaplana E, Sala I, Subirana A, Querol-Vilaseca M, Carmona-Iragui M, Illán-Gala I, Ribosa-Nogué R, Blesa R, Haass C, Fortea J, Lleó A. Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease. Scientific Reports. 9: 7803. PMID 31127154 DOI: 10.1038/s41598-019-44173-8  0.36
2019 Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, ... ... Haass C, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. Embo Molecular Medicine. PMID 31122931 DOI: 10.15252/emmm.201809711  0.48
2019 Abdelhak A, Hottenrott T, Morenas-Rodríguez E, Suárez-Calvet M, Zettl UK, Haass C, Meuth SG, Rauer S, Otto M, Tumani H, Huss A. Glial Activation Markers in CSF and Serum From Patients With Primary Progressive Multiple Sclerosis: Potential of Serum GFAP as Disease Severity Marker? Frontiers in Neurology. 10: 280. PMID 30972011 DOI: 10.3389/fneur.2019.00280  0.36
2019 Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, ... ... Haass C, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/s41380-019-0404-6  0.36
2019 Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... ... Haass C, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/brain/awz050  0.6
2019 van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, ... ... Haass C, et al. A protein quality control pathway regulated by linear ubiquitination. The Embo Journal. PMID 30886048 DOI: 10.15252/embj.2018100730  0.4
2019 Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, ... ... Haass C, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/s13024-018-0301-5  0.48
2019 Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, ... ... Haass C, et al. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience. PMID 30617257 DOI: 10.1038/s41593-018-0296-9  0.4
2018 Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, ... ... Haass C, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/emmm.201809712  0.48
2018 Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, ... ... Haass C, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/brain/awy229  0.36
2018 Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Molecular Neurodegeneration. 13: 48. PMID 30180904 DOI: 10.1186/s13024-018-0281-5  0.48
2018 Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a Journal of Neurology. PMID 29462334 DOI: 10.1093/brain/awy008  0.36
2017 Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. Embo Molecular Medicine. PMID 28855300 DOI: 10.15252/emmm.201707672  0.6
2017 Blauwendraat C, Wilke C, Simón-Sánchez J, Jansen IE, Reifschneider A, Capell A, Haass C, Castillo-Lizardo M, Biskup S, Maetzler W, Rizzu P, Heutink P, Synofzik M. The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 28749476 DOI: 10.1038/gim.2017.102  0.48
2017 Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, ... ... Haass C, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The Embo Journal. PMID 28559417 DOI: 10.15252/embj.201796516  0.36
2017 Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, ... ... Haass C, et al. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. Embo Reports. PMID 28483841 DOI: 10.15252/embr.201743922  0.48
2017 Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, ... ... Haass C, et al. Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. Embo Molecular Medicine. PMID 28351931 DOI: 10.15252/emmm.201607054  0.4
2017 Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, ... ... Haass C, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Frontiers in Aging Neuroscience. 9: 8. PMID 28197095 DOI: 10.3389/fnagi.2017.00008  0.36
2017 Gispert JD, Monté GC, Suárez-Calvet M, Falcon C, Tucholka A, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2. Alzheimer's & Dementia (Amsterdam, Netherlands). 6: 50-59. PMID 28149943 DOI: 10.1016/j.dadm.2016.12.002  0.36
2017 Ohki Y, Wenninger-Weinzierl A, Hruscha A, Asakawa K, Kawakami K, Haass C, Edbauer D, Schmid B. Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular Neurodegeneration. 12: 6. PMID 28088213 DOI: 10.1186/s13024-016-0146-8  0.4
2016 Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Science Translational Medicine. 8: 369ra178. PMID 27974666 DOI: 10.1126/scitranslmed.aag1767  0.36
2016 Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A, Hanisch F, Kamp F, Nuscher B, Orozco D, Edbauer D, Haass C. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. Embo Reports. PMID 27461252 DOI: 10.15252/embr.201541724  0.92
2016 Gispert JD, Suárez-Calvet M, Monté GC, Tucholka A, Falcon C, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27423963 DOI: 10.1016/j.jalz.2016.06.005  0.36
2016 Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. Embo Molecular Medicine. PMID 27402340 DOI: 10.15252/emmm.201606370  0.48
2016 Götzl JK, Lang CM, Haass C, Capell A. Impaired protein degradation in FTLD and related disorders. Ageing Research Reviews. PMID 27166223 DOI: 10.1016/j.arr.2016.04.008  0.48
2016 Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. Embo Molecular Medicine. PMID 26988102 DOI: 10.15252/emmm.201505952  0.92
2016 Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, ... ... Haass C, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. Embo Molecular Medicine. PMID 26941262 DOI: 10.15252/emmm.201506123  0.92
2016 Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912432 DOI: 10.2967/jnumed.115.163493  0.92
2016 Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger G, Haass C, Herms J, Rominger A. Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple Tracer PET Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912428 DOI: 10.2967/jnumed.115.167858  0.92
2016 Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, ... ... Haass C, et al. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathologica. PMID 26895297 DOI: 10.1007/s00401-016-1544-2  0.92
2016 Busche MA, Staufenbiel M, Willem M, Haass C, Förstl H. [Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets]. Der Nervenarzt. PMID 26781314 DOI: 10.1007/s00115-015-0041-5  0.92
2015 Kleinberger G, Capell A, Brouwers N, Fellerer K, Sleegers K, Cruts M, Van Broeckhoven C, Haass C. Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin. Neurobiology of Aging. PMID 26811050 DOI: 10.1016/j.neurobiolaging.2015.12.014  0.92
2015 Halder R, Hennion M, Vidal RO, Shomroni O, Rahman RU, Rajput A, Centeno TP, van Bebber F, Capece V, Vizcaino JC, Schuetz AL, Burkhardt S, Benito E, Sala MN, Javan SB, ... Haass C, et al. DNA methylation changes in plasticity genes accompany the formation and maintenance of memory. Nature Neuroscience. PMID 26656643 DOI: 10.1038/nn.4194  0.92
2015 Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröeper M, Rossner MJ, Fluhrer R, Willem M, Haass C. Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases. The Journal of Biological Chemistry. PMID 26574544 DOI: 10.1074/jbc.M115.697995  0.92
2015 Edbauer D, Haass C. An amyloid-like cascade hypothesis for C9orf72 ALS/FTD. Current Opinion in Neurobiology. 36: 99-106. PMID 26555807 DOI: 10.1016/j.conb.2015.10.009  0.92
2015 Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Molecular Psychiatry. 20: 1141. PMID 26401838 DOI: 10.1038/mp.2015.146  0.92
2015 Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, ... ... Haass C, et al. η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. PMID 26322584 DOI: 10.1038/nature14864  0.92
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/j.jalz.2015.06.1887  0.92
2015 Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nature Medicine. 21: 802-7. PMID 26099047 DOI: 10.1038/nm.3885  0.92
2015 Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment. Molecular Psychiatry. 20: 1179-87. PMID 26055427 DOI: 10.1038/mp.2015.74  0.6
2015 Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R. Secretome analysis identifies novel signal Peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple Golgi glycosylation pathways. Molecular & Cellular Proteomics : McP. 14: 1584-98. PMID 25827571 DOI: 10.1074/mcp.M115.048298  0.92
2015 Solchenberger B, Russell C, Kremmer E, Haass C, Schmid B. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. Plos One. 10: e0118956. PMID 25785851 DOI: 10.1371/journal.pone.0118956  0.92
2015 Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming P, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, Rominger A. Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models. Plos One. 10: e0116678. PMID 25706990 DOI: 10.1371/journal.pone.0116678  0.92
2015 Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R, Kurz A, Diehl-Schmid J, Hüll M, Lichtner P, Eckstein G, Zimprich A, Haubenberger D, Pirker W, Brücke T, ... ... Haass C, et al. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics : Ejhg. PMID 25604855 DOI: 10.1038/ejhg.2014.300  0.92
2015 Jäckel S, Summerer AK, Thömmes CM, Pan X, Voigt A, Schulz JB, Rasse TM, Dormann D, Haass C, Kahle PJ. Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. Neurobiology of Disease. 74: 76-88. PMID 25447237 DOI: 10.1016/j.nbd.2014.11.003  0.92
2015 Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment Molecular Psychiatry. DOI: 10.1038/mp.2015.74  0.92
2014 Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, et al. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. The Embo Journal. 33: 2890-905. PMID 25354954 DOI: 10.15252/embj.201488375  0.92
2014 Capell A, Fellerer K, Haass C. Progranulin transcripts with short and long 5' untranslated regions (UTRs) are differentially expressed via posttranscriptional and translational repression. The Journal of Biological Chemistry. 289: 25879-89. PMID 25056957 DOI: 10.1074/jbc.M114.560128  0.92
2014 Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, ... ... Haass C, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. 6: 243ra86. PMID 24990881 DOI: 10.1126/scitranslmed.3009093  0.92
2014 Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/jnc.12715  0.92
2014 Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, ... Haass C, et al. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis. Acta Neuropathologica. 127: 845-60. PMID 24619111 DOI: 10.1007/s00401-014-1262-6  0.92
2014 Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D. The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. The Embo Journal. 33: 450-67. PMID 24357581 DOI: 10.1002/embj.201385857  0.92
2014 Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M. Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Molecular Psychiatry. 19: 937-46. PMID 24061497 DOI: 10.1038/mp.2013.122  0.92
2014 Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A. Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET. Neuroimage. 84: 843-53. PMID 24055703 DOI: 10.1016/j.neuroimage.2013.09.017  0.92
2013 Hruscha A, Krawitz P, Rechenberg A, Heinrich V, Hecht J, Haass C, Schmid B. Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (Cambridge, England). 140: 4982-7. PMID 24257628 DOI: 10.1242/dev.099085  0.92
2013 Haass C. Cellular mechanisms of ALS mutations - a loss or a gain of function? Drug Research. 63: S17. PMID 24242032 DOI: 10.1055/s-0033-1346714  0.92
2013 Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D. Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathologica. 126: 881-93. PMID 24132570 DOI: 10.1007/s00401-013-1189-3  0.92
2013 Schmid B, Haass C. Genomic editing opens new avenues for zebrafish as a model for neurodegeneration. Journal of Neurochemistry. 127: 461-70. PMID 24117801 DOI: 10.1111/jnc.12460  0.92
2013 Blennow K, Zetterberg H, Haass C, Finucane T. Semagacestat's fall: where next for AD therapies? Nature Medicine. 19: 1214-5. PMID 24100981 DOI: 10.1038/nm.3365  0.92
2013 Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/s00401-013-1181-y  0.92
2013 Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R. Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 195: 703-13. PMID 23979585 DOI: 10.1534/genetics.113.156570  0.92
2013 Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. The Embo Journal. 32: 2015-28. PMID 23792428 DOI: 10.1038/emboj.2013.146  0.92
2013 McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathologica. 126: 179-88. PMID 23775142 DOI: 10.1007/s00401-013-1137-2  0.92
2013 Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, ... Haass C, et al. Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1127-34. PMID 23729696 DOI: 10.2967/jnumed.112.114660  0.92
2013 Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7856-69. PMID 23637177 DOI: 10.1523/JNEUROSCI.3372-12.2013  0.92
2013 Bentmann E, Haass C, Dormann D. Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. The Febs Journal. 280: 4348-70. PMID 23587065 DOI: 10.1111/febs.12287  0.92
2013 Sirko S, Behrendt G, Johansson PA, Tripathi P, Costa M, Bek S, Heinrich C, Tiedt S, Colak D, Dichgans M, Fischer IR, Plesnila N, Staufenbiel M, Haass C, Snapyan M, et al. Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell. 12: 426-39. PMID 23561443 DOI: 10.1016/j.stem.2013.01.019  0.92
2013 Dormann D, Haass C. Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration. Molecular and Cellular Neurosciences. 56: 475-86. PMID 23557964 DOI: 10.1016/j.mcn.2013.03.006  0.92
2013 Zhang L, Karsten P, Hamm S, Pogson JH, Müller-Rischart AK, Exner N, Haass C, Whitworth AJ, Winklhofer KF, Schulz JB, Voigt A. TRAP1 rescues PINK1 loss-of-function phenotypes. Human Molecular Genetics. 22: 2829-41. PMID 23525905 DOI: 10.1093/hmg/ddt132  0.92
2013 Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, ... ... Haass C, et al. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 110: 4986-91. PMID 23457265 DOI: 10.1073/pnas.1218311110  0.92
2013 Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13: 1519-27. PMID 23457027 DOI: 10.1002/pmic.201200582  0.92
2013 van Bebber F, Hruscha A, Willem M, Schmid B, Haass C. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. Journal of Neurochemistry. 127: 471-81. PMID 23406323 DOI: 10.1111/jnc.12198  0.92
2013 Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (New York, N.Y.). 339: 1335-8. PMID 23393093 DOI: 10.1126/science.1232927  0.92
2013 Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathologica. 125: 413-23. PMID 23381195 DOI: 10.1007/s00401-013-1088-7  0.92
2013 Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH. FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. Plos One. 8: e55243. PMID 23372841 DOI: 10.1371/journal.pone.0055243  0.92
2013 Kleinberger G, Capell A, Haass C, Van Broeckhoven C. Mechanisms of granulin deficiency: lessons from cellular and animal models. Molecular Neurobiology. 47: 337-60. PMID 23239020 DOI: 10.1007/s12035-012-8380-8  0.92
2013 Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. Journal of Neurochemistry. 125: 144-56. PMID 23237322 DOI: 10.1111/jnc.12124  0.92
2013 Poggi M, Kara I, Brunel JM, Landrier JF, Govers R, Bonardo B, Fluhrer R, Haass C, Alessi MC, Peiretti F. Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling. Biochimica Et Biophysica Acta. 1833: 602-12. PMID 23159491 DOI: 10.1016/j.bbamcr.2012.11.009  0.92
2013 Rothhämel S, Strecker K, Haass C, Schmid B. Real-Time Monitoring of Inclusion Formation in Living Zebrafish Bio-Nanoimaging: Protein Misfolding and Aggregation. 157-165. DOI: 10.1016/B978-0-12-394431-3.00014-6  0.92
2012 Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 18204-14. PMID 23238734 DOI: 10.1523/JNEUROSCI.2681-12.2012  0.92
2012 PluciÅ„ska G, Paquet D, Hruscha A, Godinho L, Haass C, Schmid B, Misgeld T. In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16203-12. PMID 23152604 DOI: 10.1523/JNEUROSCI.1327-12.2012  0.92
2012 Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). The Journal of Biological Chemistry. 287: 43401-9. PMID 23132852 DOI: 10.1074/jbc.M112.371369  0.92
2012 Dormann D, Madl T, Valori CF, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C. Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. The Embo Journal. 31: 4258-75. PMID 22968170 DOI: 10.1038/emboj.2012.261  0.92
2012 Exner N, Lutz AK, Haass C, Winklhofer KF. Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. The Embo Journal. 31: 3038-62. PMID 22735187 DOI: 10.1038/emboj.2012.170  0.92
2012 Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S. Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. The Journal of Pathology. 228: 67-76. PMID 22733568 DOI: 10.1002/path.4043  0.92
2012 Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. The Embo Journal. 31: 3157-68. PMID 22728825 DOI: 10.1038/emboj.2012.173  0.92
2012 Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. Embo Reports. 13: 759-64. PMID 22710833 DOI: 10.1038/embor.2012.90  0.92
2012 Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C. Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). The Journal of Biological Chemistry. 287: 23079-94. PMID 22563080 DOI: 10.1074/jbc.M111.328757  0.92
2012 Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine. 2: a006270. PMID 22553493 DOI: 10.1101/cshperspect.a006270  0.92
2012 Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. The Journal of Biological Chemistry. 287: 19355-65. PMID 22511793 DOI: 10.1074/jbc.M112.365098  0.92
2012 Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, et al. Generation of a novel rodent model for DYT1 dystonia. Neurobiology of Disease. 47: 61-74. PMID 22472189 DOI: 10.1016/j.nbd.2012.03.024  0.92
2012 Fleck D, Garratt AN, Haass C, Willem M. BACE1 dependent neuregulin processing: review. Current Alzheimer Research. 9: 178-83. PMID 22455478 DOI: 10.2174/156720512799361637  0.92
2012 Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, ... Haass C, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxidants & Redox Signaling. 16: 1421-33. PMID 22229260 DOI: 10.1089/ars.2011.4173  0.92
2012 Fluhrer R, Martin L, Klier B, Haug-Kröper M, Grammer G, Nuscher B, Haass C. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). The Journal of Biological Chemistry. 287: 5156-63. PMID 22194595 DOI: 10.1074/jbc.M111.328104  0.92
2012 Velanac V, Unterbarnscheidt T, Hinrichs W, Gummert MN, Fischer TM, Rossner MJ, Trimarco A, Brivio V, Taveggia C, Willem M, Haass C, Möbius W, Nave KA, Schwab MH. Bace1 processing of NRG1 type III produces a myelin-inducing signal but is not essential for the stimulation of myelination. Glia. 60: 203-17. PMID 22052506 DOI: 10.1002/glia.21255  0.92
2011 Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C. Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. The Journal of Biological Chemistry. 286: 45063-72. PMID 22065584 DOI: 10.1074/jbc.M111.296921  0.92
2011 Ebke A, Luebbers T, Fukumori A, Shirotani K, Haass C, Baumann K, Steiner H. Novel γ-secretase enzyme modulators directly target presenilin protein. The Journal of Biological Chemistry. 286: 37181-6. PMID 21896486 DOI: 10.1074/jbc.C111.276972  0.92
2011 Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : a Journal of Neurology. 134: 2595-609. PMID 21856723 DOI: 10.1093/brain/awr201  0.92
2011 Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C. The Nicastrin ectodomain adopts a highly thermostable structure. Biological Chemistry. 392: 995-1001. PMID 21848507 DOI: 10.1515/BC.2011.169  0.92
2011 Dormann D, Haass C. TDP-43 and FUS: a nuclear affair. Trends in Neurosciences. 34: 339-48. PMID 21700347 DOI: 10.1016/j.tins.2011.05.002  0.92
2011 Lichtenthaler SF, Haass C, Steiner H. Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing. Journal of Neurochemistry. 117: 779-96. PMID 21413990 DOI: 10.1111/j.1471-4159.2011.07248.x  0.92
2011 Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H. Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. The Journal of Biological Chemistry. 286: 15240-51. PMID 21357415 DOI: 10.1074/jbc.M110.213587  0.92
2011 Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, ... ... Haass C, et al. Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1885-94. PMID 21289198 DOI: 10.1523/JNEUROSCI.5757-10.2011  0.92
2011 Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/s00702-010-0572-7  0.92
2011 Haass C, Hemmer B, Meyer B, Halle M, Förstl H. In Reply | Schlusswort Deutsches Arzteblatt. 108: 146. DOI: 10.3238/arztebl.2011.0146  0.92
2010 Förstl H, Haass C, Hemmer B, Meyer B, Halle M. Boxing-acute complications and late sequelae: from concussion to dementia. Deutsches ÄRzteblatt International. 107: 835-9. PMID 21173899 DOI: 10.3238/arztebl.2010.0835  0.92
2010 Haass C. Initiation and propagation of neurodegeneration. Nature Medicine. 16: 1201-4. PMID 21052073 DOI: 10.1038/nm.2223  0.92
2010 Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K. The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophysical Journal. 99: 2116-24. PMID 20923645 DOI: 10.1016/j.bpj.2010.06.035  0.92
2010 Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C. Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. The Embo Journal. 29: 3571-89. PMID 20842103 DOI: 10.1038/emboj.2010.223  0.92
2010 Haass C, Mandelkow E. Fyn-tau-amyloid: a toxic triad. Cell. 142: 356-8. PMID 20691893 DOI: 10.1016/j.cell.2010.07.032  0.92
2010 Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. Plos One. 5: e11783. PMID 20689587 DOI: 10.1371/journal.pone.0011783  0.92
2010 Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. The Embo Journal. 29: 2841-57. PMID 20606625 DOI: 10.1038/emboj.2010.143  0.92
2010 Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, et al. Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8974-83. PMID 20592218 DOI: 10.1523/JNEUROSCI.1199-10.2010  0.92
2010 Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. The Journal of Biological Chemistry. 285: 26174-81. PMID 20538592 DOI: 10.1074/jbc.M110.132548  0.92
2010 Fukumori A, Fluhrer R, Steiner H, Haass C. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7853-62. PMID 20534834 DOI: 10.1523/JNEUROSCI.1443-10.2010  0.92
2010 van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiology of Disease. 39: 265-71. PMID 20381619 DOI: 10.1016/j.nbd.2010.03.023  0.92
2010 Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. The Journal of Biological Chemistry. 285: 17798-810. PMID 20348104 DOI: 10.1074/jbc.M110.103283  0.92
2010 Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C. Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. The Journal of Biological Chemistry. 285: 15753-60. PMID 20348102 DOI: 10.1074/jbc.M110.110742  0.92
2010 Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nature Neuroscience. 13: 411-3. PMID 20305648 DOI: 10.1038/nn.2511  0.92
2010 Paquet D, Schmid B, Haass C. Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo. Neuro-Degenerative Diseases. 7: 99-102. PMID 20173336 DOI: 10.1159/000285515  0.92
2010 Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. Journal of Neurochemistry. 112: 940-50. PMID 20021564 DOI: 10.1111/j.1471-4159.2009.06510.x  0.92
2010 Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C. Masking of transmembrane-based retention signals controls ER export of gamma-secretase. Traffic (Copenhagen, Denmark). 11: 250-8. PMID 19958468 DOI: 10.1111/j.1600-0854.2009.01014.x  0.92
2010 Winklhofer KF, Haass C. Mitochondrial dysfunction in Parkinson's disease. Biochimica Et Biophysica Acta. 1802: 29-44. PMID 19733240 DOI: 10.1016/j.bbadis.2009.08.013  0.92
2009 Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, ... ... Haass C, et al. The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. Embo Molecular Medicine. 1: 223-35. PMID 20049724 DOI: 10.1002/emmm.200900026  0.92
2009 Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, ... ... Haass C, et al. Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor. Neuro-Degenerative Diseases. 6: 230-9. PMID 19738368 DOI: 10.1159/000236902  0.92
2009 Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J. Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10405-9. PMID 19692615 DOI: 10.1523/JNEUROSCI.2288-09.2009  0.92
2009 Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, ... ... Haass C, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. Plos One. 4: e6629. PMID 19680561 DOI: 10.1371/journal.pone.0006629  0.92
2009 Lutz AK, Exner N, Fett ME, Schlehe JS, Kloos K, Lämmermann K, Brunner B, Kurz-Drexler A, Vogel F, Reichert AS, Bouman L, Vogt-Weisenhorn D, Wurst W, Tatzelt J, Haass C, et al. Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. The Journal of Biological Chemistry. 284: 22938-51. PMID 19546216 DOI: 10.1074/jbc.M109.035774  0.92
2009 Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. Journal of Neurochemistry. 110: 1082-94. PMID 19522733 DOI: 10.1111/j.1471-4159.2009.06211.x  0.92
2009 Willem M, Lammich S, Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Seminars in Cell & Developmental Biology. 20: 175-82. PMID 19429494 DOI: 10.1016/j.semcdb.2009.01.003  0.92
2009 Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. The Journal of Clinical Investigation. 119: 1382-95. PMID 19363289 DOI: 10.1172/JCI37537  0.92
2009 Fluhrer R, Steiner H, Haass C. Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. The Journal of Biological Chemistry. 284: 13975-9. PMID 19189970 DOI: 10.1074/jbc.R800040200  0.92
2009 Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry. 48: 1183-97. PMID 19159235 DOI: 10.1021/bi801204g  0.92
2009 Martin L, Fluhrer R, Haass C. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. The Journal of Biological Chemistry. 284: 5662-70. PMID 19114711 DOI: 10.1074/jbc.M807485200  0.92
2008 O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/j.neuron.2008.10.047  0.92
2008 Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 321: 1686-9. PMID 18802001 DOI: 10.1126/science.1162844  0.92
2008 Steiner H, Winkler E, Haass C. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. The Journal of Biological Chemistry. 283: 34677-86. PMID 18801744 DOI: 10.1074/jbc.M709067200  0.92
2008 Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. The Journal of Biological Chemistry. 283: 30121-8. PMID 18768471 DOI: 10.1074/jbc.M806092200  0.92
2008 Steiner H, Fluhrer R, Haass C. Intramembrane proteolysis by gamma-secretase. The Journal of Biological Chemistry. 283: 29627-31. PMID 18650432 DOI: 10.1074/jbc.R800010200  0.92
2008 Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. 105: 9775-80. PMID 18626010 DOI: 10.1073/pnas.0800507105  0.92
2008 St George-Hyslop P, Haass C. Regulatory RNA goes awry in Alzheimer's disease. Nature Medicine. 14: 711-2. PMID 18607365 DOI: 10.1038/nm0708-711  0.92
2008 Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. The Journal of Biological Chemistry. 283: 14257-68. PMID 18353773 DOI: 10.1074/jbc.M801531200  0.92
2008 Winklhofer KF, Tatzelt J, Haass C. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. The Embo Journal. 27: 336-49. PMID 18216876 DOI: 10.1038/sj.emboj.7601930  0.92
2008 Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. The Journal of Biological Chemistry. 283: 1744-53. PMID 17984093 DOI: 10.1074/jbc.M705115200  0.92
2008 Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. The Journal of Biological Chemistry. 283: 1644-52. PMID 17965014 DOI: 10.1074/jbc.M706661200  0.92
2008 Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. The Journal of Biological Chemistry. 283: 677-83. PMID 17962197 DOI: 10.1074/jbc.M708754200  0.92
2007 Exner N, Treske B, Paquet D, Holmström K, Schiesling C, Gispert S, Carballo-Carbajal I, Berg D, Hoepken HH, Gasser T, Krüger R, Winklhofer KF, Vogel F, Reichert AS, Auburger G, ... ... Haass C, et al. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12413-8. PMID 17989306 DOI: 10.1523/JNEUROSCI.0719-07.2007  0.92
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/jbc.M705248200  0.92
2007 Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhövd C, Reichert AS, Kretzschmar HA, Haass C, Herms J. Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. Journal of Neurochemistry. 102: 1264-75. PMID 17763532 DOI: 10.1111/j.1471-4159.2007.04627.x  0.92
2007 Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. Embo Reports. 8: 743-8. PMID 17668005 DOI: 10.1038/sj.embor.7401027  0.92
2007 Fluhrer R, Haass C. Signal peptide peptidases and gamma-secretase: cousins of the same protease family? Neuro-Degenerative Diseases. 4: 112-6. PMID 17596705 DOI: 10.1159/000101835  0.92
2007 Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiology of Disease. 27: 102-7. PMID 17560791 DOI: 10.1016/j.nbd.2007.04.011  0.92
2007 Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. The Journal of Biological Chemistry. 282: 14083-93. PMID 17360711 DOI: 10.1074/jbc.M608437200  0.92
2007 Görner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. The Journal of Biological Chemistry. 282: 13680-91. PMID 17331951 DOI: 10.1074/jbc.M609821200  0.92
2007 Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. The Journal of Biological Chemistry. 282: 11982-95. PMID 17307738 DOI: 10.1074/jbc.M700356200  0.92
2007 Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. The Journal of Biological Chemistry. 282: 10632-8. PMID 17261586 DOI: 10.1074/jbc.M611033200  0.92
2007 Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/nrm2101  0.92
2007 Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B. Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. The Journal of Biological Chemistry. 282: 9195-203. PMID 17170113 DOI: 10.1074/jbc.M607865200  0.92
2007 Narlawar R, Pérez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B. N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase. Bioorganic & Medicinal Chemistry Letters. 17: 176-82. PMID 17035010 DOI: 10.1016/j.bmcl.2006.09.061  0.92
2007 Freichel C, Neumann M, Ballard T, Müller V, Woolley M, Ozmen L, Borroni E, Kretzschmar HA, Haass C, Spooren W, Kahle PJ. Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiology of Aging. 28: 1421-35. PMID 16872721 DOI: 10.1016/j.neurobiolaging.2006.06.013  0.92
2007 Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiology of Aging. 28: 1221-30. PMID 16815595 DOI: 10.1016/j.neurobiolaging.2006.05.029  0.92
2006 Narlawar R, Pérez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K. Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. Journal of Medicinal Chemistry. 49: 7588-91. PMID 17181139 DOI: 10.1021/jm0610200  0.92
2006 Haffner C, Haass C. Cellular functions of gamma-secretase-related proteins. Neuro-Degenerative Diseases. 3: 284-9. PMID 17047369 DOI: 10.1159/000095268  0.92
2006 Kaether C, Haass C, Steiner H. Assembly, trafficking and function of gamma-secretase. Neuro-Degenerative Diseases. 3: 275-83. PMID 17047368 DOI: 10.1159/000095267  0.92
2006 Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science (New York, N.Y.). 314: 664-6. PMID 16990514 DOI: 10.1126/science.1132341  0.92
2006 Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. Embo Reports. 7: 940-6. PMID 16906128 DOI: 10.1038/sj.embor.7400784  0.92
2006 Steiner H, Than M, Bode W, Haass C. Pore-forming scissors? A first structural glimpse of gamma-secretase. Trends in Biochemical Sciences. 31: 491-3. PMID 16890442 DOI: 10.1016/j.tibs.2006.07.008  0.92
2006 Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR. Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology. Brain : a Journal of Neurology. 129: 2992-3005. PMID 16844716 DOI: 10.1093/brain/awl176  0.92
2006 Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nature Cell Biology. 8: 894-6. PMID 16829951 DOI: 10.1038/ncb1450  0.92
2006 Avila J, Nitsch RM, Haass C, De Strooper B. European Alzheimer disease funding. Nature Medicine. 12: 776-7. PMID 16829945 DOI: 10.1038/nm0706-776  0.92
2006 Wild-Bode C, Fellerer K, Kugler J, Haass C, Capell A. A basolateral sorting signal directs ADAM10 to adherens junctions and is required for its function in cell migration. The Journal of Biological Chemistry. 281: 23824-9. PMID 16777847 DOI: 10.1074/jbc.M601542200  0.92
2006 Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM. Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (Copenhagen, Denmark). 7: 873-88. PMID 16734669 DOI: 10.1111/j.1600-0854.2006.00434.x  0.92
2006 Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A. Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Molecular and Cellular Biology. 26: 3917-34. PMID 16648485 DOI: 10.1128/MCB.26.10.3917-3934.2006  0.92
2006 Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, et al. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. Biochemistry. 45: 4907-14. PMID 16605258 DOI: 10.1021/bi052412w  0.92
2006 Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3821-8. PMID 16597736 DOI: 10.1523/JNEUROSCI.5354-05.2006  0.92
2006 Kaether C, Schmitt S, Willem M, Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic (Copenhagen, Denmark). 7: 408-15. PMID 16536739 DOI: 10.1111/j.1600-0854.2006.00396.x  0.92
2006 Böhm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W. SorLA signaling by regulated intramembrane proteolysis. The Journal of Biological Chemistry. 281: 14547-53. PMID 16531402 DOI: 10.1074/jbc.M601660200  0.92
2006 Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. The Journal of Biological Chemistry. 281: 7890-8. PMID 16434391 DOI: 10.1074/jbc.M513250200  0.92
2006 Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. The Journal of Biological Chemistry. 281: 7583-94. PMID 16344553 DOI: 10.1074/jbc.M508340200  0.92
2006 Haass C, Multhaup G. Six years of collaborative Alzheimer's disease research in Germany Neurodegenerative Diseases. 3: 193-196. DOI: 10.1159/000095256  0.92
2005 Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/s00401-005-1053-1  0.92
2005 Straub T, Neumann MF, Prestel M, Kremmer E, Kaether C, Haass C, Becker PB. Stable chromosomal association of MSL2 defines a dosage-compensated nuclear compartment. Chromosoma. 114: 352-64. PMID 16179989 DOI: 10.1007/s00412-005-0020-x  0.92
2005 Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. The Journal of Biological Chemistry. 280: 39515-23. PMID 15998642 DOI: 10.1074/jbc.M501645200  0.92
2005 Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, Kretzschmar H. Single particle detection and characterization of synuclein co-aggregation. Biochemical and Biophysical Research Communications. 333: 1202-10. PMID 15978545 DOI: 10.1016/j.bbrc.2005.06.025  0.92
2005 Prokop S, Haass C, Steiner H. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. Journal of Neurochemistry. 94: 57-62. PMID 15953349 DOI: 10.1111/j.1471-4159.2005.03165.x  0.92
2005 Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Molecular and Cellular Neurosciences. 29: 453-61. PMID 15886016 DOI: 10.1016/j.mcn.2005.03.014  0.92
2005 Stefanova N, Reindl M, Neumann M, Haass C, Poewe W, Kahle PJ, Wenning GK. Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. The American Journal of Pathology. 166: 869-76. PMID 15743798  0.92
2005 Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C. A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. The Journal of Biological Chemistry. 280: 5137-40. PMID 15615717 DOI: 10.1074/jbc.C400560200  0.92
2005 Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C. Gamma-secretase complex assembly within the early secretory pathway. The Journal of Biological Chemistry. 280: 6471-8. PMID 15591316 DOI: 10.1074/jbc.M409106200  0.92
2005 Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C. Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. The Journal of Biological Chemistry. 280: 3390-9. PMID 15557340 DOI: 10.1074/jbc.M407724200  0.92
2005 Andersson CX, Fernandez-Rodriguez J, Laos S, Baeckström D, Haass C, Hansson GC. Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43. The Biochemical Journal. 387: 377-84. PMID 15540986 DOI: 10.1042/BJ20041387  0.92
2005 Kahle PJ, Haass C. Alzheimer's Disease and Other Neurodegenerative Diseases Neuroprotection: Models, Mechanisms and Therapies. 71-83. DOI: 10.1002/3527603867.ch4  0.92
2004 Haffner C, Haass C. The biochemical and genetic odyssey to the function of a nicastrin-like protein. Neuro-Degenerative Diseases. 1: 192-5. PMID 16908989 DOI: 10.1159/000080985  0.92
2004 Neumann M, Müller V, Kretzschmar HA, Haass C, Kahle PJ. Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage. Journal of Neuropathology and Experimental Neurology. 63: 1225-35. PMID 15624759  0.92
2004 Kaether C, Haass C. A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation. The Journal of Cell Biology. 167: 809-12. PMID 15583026 DOI: 10.1083/jcb.200410090  0.92
2004 Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. The Embo Journal. 23: 4738-48. PMID 15549135 DOI: 10.1038/sj.emboj.7600478  0.92
2004 Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. The American Journal of Pathology. 165: 1621-31. PMID 15509532  0.92
2004 Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. The Journal of Biological Chemistry. 279: 53205-12. PMID 15485862 DOI: 10.1074/jbc.M410378200  0.92
2004 Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Müller-Spahn F, Haass C, Czech C, Pradier L, Müller WE, Eckert A. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. The Journal of Biological Chemistry. 279: 50310-20. PMID 15371443 DOI: 10.1074/jbc.M405600200  0.92
2004 Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. The Journal of Biological Chemistry. 279: 41340-5. PMID 15286082 DOI: 10.1074/jbc.M405768200  0.92
2004 Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. The Embo Journal. 23: 3041-50. PMID 15257293 DOI: 10.1038/sj.emboj.7600307  0.92
2004 Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G. Human BACE forms dimers and colocalizes with APP. The Journal of Biological Chemistry. 279: 39710-7. PMID 15247262 DOI: 10.1074/jbc.M402785200  0.92
2004 Kahle PJ, Haass C. How does parkin ligate ubiquitin to Parkinson's disease? Embo Reports. 5: 681-5. PMID 15229644 DOI: 10.1038/sj.embor.7400188  0.92
2004 Edbauer D, Kaether C, Steiner H, Haass C. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. The Journal of Biological Chemistry. 279: 37311-5. PMID 15210705 DOI: 10.1074/jbc.M406228200  0.92
2004 Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. Journal of Neurochemistry. 89: 1520-7. PMID 15189355 DOI: 10.1111/j.1471-4159.2004.02447.x  0.92
2004 Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C. Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. Embo Reports. 5: 620-5. PMID 15167888 DOI: 10.1038/sj.embor.7400166  0.92
2004 Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. The Journal of Biological Chemistry. 279: 23255-61. PMID 15039426 DOI: 10.1074/jbc.M401789200  0.92
2004 Nuscher B, Kamp F, Mehnert T, Odoy S, Haass C, Kahle PJ, Beyer K. Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study. The Journal of Biological Chemistry. 279: 21966-75. PMID 15028717 DOI: 10.1074/jbc.M401076200  0.92
2004 Neumann M, Müller V, Görner K, Kretzschmar HA, Haass C, Kahle PJ. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathologica. 107: 489-96. PMID 14991385 DOI: 10.1007/s00401-004-0834-2  0.92
2003 Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. The Journal of Biological Chemistry. 278: 52519-23. PMID 14602727 DOI: 10.1074/jbc.C300435200  0.6
2003 Aguzzi A, Haass C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science (New York, N.Y.). 302: 814-8. PMID 14593165 DOI: 10.1126/science.1087348  1
2003 Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. The Journal of Biological Chemistry. 278: 48713-9. PMID 14507929 DOI: 10.1074/jbc.M303861200  0.92
2003 Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/jbc.M211161200  0.92
2003 Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nature Cell Biology. 5: 486-8. PMID 12679784 DOI: 10.1038/ncb960  0.6
2003 Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C. Gamma-secretase activity is associated with a conformational change of nicastrin. The Journal of Biological Chemistry. 278: 16474-7. PMID 12644462 DOI: 10.1074/jbc.C300095200  0.6
2003 Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. The Journal of Biological Chemistry. 278: 5531-8. PMID 12471021 DOI: 10.1074/jbc.M211485200  0.92
2002 Haass C, Steiner H. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends in Cell Biology. 12: 556-62. PMID 12495843  0.6
2002 Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/JCI15777  0.92
2002 Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/emboj/cdf541  0.92
2002 Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. The Journal of Biological Chemistry. 277: 44754-9. PMID 12223485 DOI: 10.1074/jbc.M206872200  0.6
2002 Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. The Journal of Biological Chemistry. 277: 39062-5. PMID 12198112 DOI: 10.1074/jbc.C200469200  0.6
2002 Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. The Journal of Cell Biology. 158: 551-61. PMID 12147673 DOI: 10.1083/jcb.200201123  0.6
2002 Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. Embo Reports. 3: 688-94. PMID 12101103 DOI: 10.1093/embo-reports/kvf124  0.92
2002 Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J. A non-amyloidogenic function of BACE-2 in the secretory pathway. Journal of Neurochemistry. 81: 1011-20. PMID 12065613 DOI: 10.1046/j.1471-4159.2002.00908.x  0.92
2002 Edbauer D, Winkler E, Haass C, Steiner H. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 8666-71. PMID 12048259 DOI: 10.1073/pnas.132277899  0.6
2002 Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proceedings of the National Academy of Sciences of the United States of America. 99: 8025-30. PMID 12048239 DOI: 10.1073/pnas.112686799  0.6
2002 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C. Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. Embo Reports. 3: 583-8. PMID 12034752 DOI: 10.1093/embo-reports/kvf109  0.92
2002 Thal DR, Ghebremedhin E, Haass C, Schultz C. UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain. Clinical Neuropathology. 21: 35-40. PMID 11846043  0.92
2002 Edbauer D, Willem M, Lammich S, Steiner H, Haass C. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). The Journal of Biological Chemistry. 277: 13389-93. PMID 11809755 DOI: 10.1074/jbc.M111571200  0.92
2002 Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C. Apical sorting of beta-secretase limits amyloid beta-peptide production. The Journal of Biological Chemistry. 277: 5637-43. PMID 11741885 DOI: 10.1074/jbc.M109119200  0.92
2001 Steiner H, Haass C. Nuclear signaling: a common function of presenilin substrates? Journal of Molecular Neuroscience : Mn. 17: 193-8. PMID 11816792 DOI: 10.1385/JMN:17:2:193  0.6
2001 Walter J, Kaether C, Steiner H, Haass C. The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Current Opinion in Neurobiology. 11: 585-90. PMID 11595492  0.6
2001 Haass C, Steiner H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? Nature Neuroscience. 4: 859-60. PMID 11528409 DOI: 10.1038/nn0901-859  0.6
2001 Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. Embo Reports. 2: 835-41. PMID 11520861 DOI: 10.1093/embo-reports/kve180  0.92
2001 Steiner H, Winkler E, Shearman MS, Prywes R, Haass C. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins. Neurobiology of Disease. 8: 717-22. PMID 11493036 DOI: 10.1006/nbdi.2001.0405  0.6
2001 Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Müller WE. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. Journal of Neuroscience Research. 64: 183-92. PMID 11288146  0.32
2001 Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C. Phosphorylation regulates intracellular trafficking of beta-secretase. The Journal of Biological Chemistry. 276: 14634-41. PMID 11278841 DOI: 10.1074/jbc.M011116200  0.92
2001 Yamazaki T, Chang TY, Haass C, Ihara Y. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. The Journal of Biological Chemistry. 276: 4454-60. PMID 11085995 DOI: 10.1074/jbc.M009598200  0.92
2001 Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques. The Journal of Biological Chemistry. 276: 7233-9. PMID 11084029 DOI: 10.1074/jbc.M007183200  0.6
2000 Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, et al. Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurologica Scandinavica. Supplementum. 176: 6-11. PMID 11261807  0.92
2000 Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nature Reviews. Molecular Cell Biology. 1: 217-24. PMID 11252897 DOI: 10.1038/35043065  0.6
2000 Kahle PJ, Leimer U, Haass C. Does failure of parkin-mediated ubiquitination cause juvenile parkinsonism? Trends in Biochemical Sciences. 25: 524-7. PMID 11084358  0.32
2000 Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nature Cell Biology. 2: 848-51. PMID 11056541 DOI: 10.1038/35041097  0.92
2000 Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C. A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. The Journal of Biological Chemistry. 275: 40925-32. PMID 11013240 DOI: 10.1074/jbc.M005254200  0.6
2000 Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6365-73. PMID 10964942  0.32
2000 Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, et al. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. The Journal of Biological Chemistry. 275: 27348-53. PMID 10856299 DOI: 10.1074/jbc.M002982200  0.92
2000 Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C. Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences of the United States of America. 97: 5913-8. PMID 10811883 DOI: 10.1073/pnas.100049897  0.92
2000 Walter J, Schindzielorz A, Hartung B, Haass C. Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2. The Journal of Biological Chemistry. 275: 23523-9. PMID 10806211 DOI: 10.1074/jbc.M002850200  0.32
2000 Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. Maturation and pro-peptide cleavage of beta-secretase. The Journal of Biological Chemistry. 275: 30849-54. PMID 10801872 DOI: 10.1074/jbc.M003202200  0.92
2000 Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nature Cell Biology. 2: 205-11. PMID 10783238 DOI: 10.1038/35008626  0.92
1999 Steiner H, Capell A, Leimer U, Haass C. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 249: 266-70. PMID 10653281  0.6
1999 Steiner H, Pesold B, Haass C. An in vivo assay for the identification of target proteases which cleave membrane-associated substrates. Febs Letters. 463: 245-9. PMID 10606730  0.6
1999 Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 38: 14600-5. PMID 10545183 DOI: 10.1021/bi9914210  0.92
1999 Sandmann-Keil D, Braak H, Okochi M, Haass C, Braak E. Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique. Acta Neuropathologica. 98: 461-4. PMID 10541868 DOI: 10.1007/s004010051110  0.92
1999 Leimer U, Lun K, Romig H, Walter J, Grünberg J, Brand M, Haass C. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38: 13602-9. PMID 10521267 DOI: 10.1021/bi991453n  0.92
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... ... Haass C, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/jbc.274.40.28669  0.92
1999 Guénette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE. hFE65L influences amyloid precursor protein maturation and secretion. Journal of Neurochemistry. 73: 985-93. PMID 10461887 DOI: 10.1046/j.1471-4159.1999.0730985.x  0.92
1999 Haass C, Mandelkow E. Proteolysis by presenilins and the renaissance of tau. Trends in Cell Biology. 9: 241-4. PMID 10408925 DOI: 10.1016/S0962-8924(99)01576-7  0.92
1999 Diehlmann A, Ida N, Weggen S, Grünberg J, Haass C, Masters CL, Bayer TA, Beyreuther K. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. Journal of Neuroscience Research. 56: 405-19. PMID 10340748 DOI: 10.1002/(SICI)1097-4547(19990515)56:4<405::AID-JNR8>3.0.CO;2-F  0.92
1999 Steiner H, Capell A, Haass C. Proteolytic processing and degradation of Alzheimer's disease relevant proteins. Biochemical Society Transactions. 27: 234-42. PMID 10093740  0.6
1999 Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C. The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. The Journal of Biological Chemistry. 274: 7615-8. PMID 10075646  0.6
1999 Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. Journal of Neuropathology and Experimental Neurology. 58: 210-6. PMID 10029103  0.92
1999 Walter J, Schindzielorz A, Grünberg J, Haass C. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 1391-6. PMID 9990034  0.32
1998 Grünberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C. Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. Neuroreport. 9: 3293-9. PMID 9831466  0.48
1998 Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712  0.96
1998 Haass C, Grünberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R. Proteolytic processing of Alzheimer's disease associated proteins. Journal of Neural Transmission. Supplementum. 53: 159-67. PMID 9700654  0.52
1998 Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880  0.92
1998 Walter J, Grünberg J, Schindzielorz A, Haass C. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry. 37: 5961-7. PMID 9558331 DOI: 10.1021/bi971763a  0.32
1998 Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432  0.96
1998 Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800  0.96
1997 Baumeister R, Leimer U, Zweckbronner I, Jakubek C, Grünberg J, Haass C. Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing. Genes and Function. 1: 149-59. PMID 9680315  0.32
1997 Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676  0.92
1997 Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/bi970209y  0.92
1997 Wild-Bode C, Yamazaki T, Capell A, Leimer U, Steiner H, Ihara Y, Haass C. Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42. The Journal of Biological Chemistry. 272: 16085-8. PMID 9195901 DOI: 10.1074/jbc.272.26.16085  0.92
1997 Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/nbdi.1997.0129  0.92
1997 Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240  0.96
1997 Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/jbc.272.12.7977  0.92
1997 Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898  0.48
1997 Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878  0.96
1996 Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483  0.96
1996 Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1  0.92
1996 Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/jbc.271.14.8443  0.92
1996 Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127  0.92
1995 Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/jbc.270.11.6186  0.92
1995 Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/jcb.128.4.537  0.92
1995 Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452  0.92
1995 Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468 DOI: 10.1042/bj3110299  0.92
1995 Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411  0.92
1994 Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445  0.92
1994 Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287  0.92
1994 Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 30966-73. PMID 7983032  0.92
1993 Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976  0.92
1993 Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660  0.96
1993 Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505  0.96
1993 Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/j.1749-6632.1993.tb23037.x  0.92
1993 Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807  0.92
1992 Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G  0.92
1992 Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500a0  0.96
1992 Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672a0  0.92
1992 Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654  0.96
1992 Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359: 322-5. PMID 1383826 DOI: 10.1038/359322a0  0.92
1991 Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690  0.96
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