| Year |
Citation |
Score |
| 2025 |
Takalo M, Jeskanen H, Rolova T, Kervinen I, Hellén M, Heikkinen S, Koivisto H, Jokivarsi K, Müller SA, Koivumäki EM, Mäkinen P, Juopperi SP, Willman RM, Sinisalo R, Hoffmann D, ... ... Haass C, et al. The protective PLCγ2-P522R variant mitigates Alzheimer's disease-associated pathologies by enhancing beneficial microglial functions. Journal of Neuroinflammation. 22: 64. PMID 40038760 DOI: 10.1186/s12974-025-03387-6 |
0.322 |
|
| 2025 |
Biel D, Suárez-Calvet M, Dewenter A, Steward A, Roemer SN, Dehsarvi A, Zhu Z, Pescoller J, Frontzkowski L, Kreuzer A, Haass C, Schöll M, Brendel M, Franzmeier N. Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer's disease. Embo Molecular Medicine. PMID 39794447 DOI: 10.1038/s44321-024-00190-3 |
0.524 |
|
| 2024 |
Shojaei M, Schaefer R, Schlepckow K, Kunze LH, Struebing FL, Brunner B, Willem M, Bartos LM, Feiten A, Palumbo G, Arzberger T, Bartenstein P, Parico GC, Xia D, Monroe KM, ... Haass C, et al. PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies. Theranostics. 14: 6319-6336. PMID 39431020 DOI: 10.7150/thno.97149 |
0.482 |
|
| 2024 |
Kaji S, Berghoff SA, Spieth L, Schlaphoff L, Sasmita AO, Vitale S, Büschgens L, Kedia S, Zirngibl M, Nazarenko T, Damkou A, Hosang L, Depp C, Kamp F, Scholz P, ... ... Haass C, et al. Apolipoprotein E aggregation in microglia initiates Alzheimer's disease pathology by seeding β-amyloidosis. Immunity. PMID 39419029 DOI: 10.1016/j.immuni.2024.09.014 |
0.324 |
|
| 2024 |
Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D. Correction to: Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathologica. 148: 48. PMID 39367895 DOI: 10.1007/s00401-024-02806-x |
0.57 |
|
| 2024 |
Zatcepin A, Gnörich J, Rauchmann BS, Bartos LM, Wagner S, Franzmeier N, Malpetti M, Xiang X, Shi Y, Parhizkar S, Grosch M, Wind-Mark K, Kunte ST, Beyer L, Meyer C, ... ... Haass C, et al. Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer's disease. Molecular Neurodegeneration. 19: 64. PMID 39238030 DOI: 10.1186/s13024-024-00752-6 |
0.804 |
|
| 2024 |
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, ... ... Haass C, et al. Author Correction: Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience. PMID 39143410 DOI: 10.1038/s41593-024-01752-x |
0.796 |
|
| 2024 |
Hu Y, Hruscha A, Pan C, Schifferer M, Schmidt MK, Nuscher B, Giera M, Kostidis S, Burhan Ö, van Bebber F, Edbauer D, Arzberger T, Haass C, Schmid B. Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits. Molecular Neurodegeneration. 19: 50. PMID 38902734 DOI: 10.1186/s13024-024-00735-7 |
0.546 |
|
| 2024 |
Ramalingam N, Haass C, Dettmer U. Physiological roles of α-synuclein serine-129 phosphorylation - not an oxymoron. Trends in Neurosciences. 47: 480-490. PMID 38862330 DOI: 10.1016/j.tins.2024.05.005 |
0.795 |
|
| 2024 |
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D. Author Correction: Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. Embo Reports. PMID 38849674 DOI: 10.1038/s44319-024-00163-0 |
0.537 |
|
| 2024 |
Reich M, Simon MJ, Polke B, Paris I, Werner G, Schrader C, Spieth L, Davis SS, Robinson S, de Melo GL, Schlaphoff L, Buschmann K, Berghoff S, Logan T, Nuscher B, ... ... Haass C, et al. Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration. Science Translational Medicine. 16: eadj7308. PMID 38838131 DOI: 10.1126/scitranslmed.adj7308 |
0.588 |
|
| 2023 |
Palleis C, Franzmeier N, Weidinger E, Bernhardt AM, Katzdobler S, Wall S, Ferschmann C, Harris S, Schmitt J, Schuster S, Gnörich J, Finze A, Biechele G, Lindner S, Albert NL, ... ... Haass C, et al. Association of Neurofilament Light Chain, [F]PI-2620 Tau-PET, TSPO-PET, and Clinical Progression in Patients With β-Amyloid-Negative CBS. Neurology. 102: e207901. PMID 38165362 DOI: 10.1212/WNL.0000000000207901 |
0.526 |
|
| 2023 |
Schlepckow K, Morenas-Rodríguez E, Hong S, Haass C. Stimulation of TREM2 with agonistic antibodies-an emerging therapeutic option for Alzheimer's disease. The Lancet. Neurology. 22: 1048-1060. PMID 37863592 DOI: 10.1016/S1474-4422(23)00247-8 |
0.559 |
|
| 2023 |
Kolabas ZI, Kuemmerle LB, Perneczky R, Förstera B, Ulukaya S, Ali M, Kapoor S, Bartos LM, Büttner M, Caliskan OS, Rong Z, Mai H, Höher L, Jeridi D, Molbay M, ... ... Haass C, et al. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. PMID 37562402 DOI: 10.1016/j.cell.2023.07.009 |
0.453 |
|
| 2023 |
Johnson ECB, Bian S, Haque RU, Carter EK, Watson CM, Gordon BA, Ping L, Duong DM, Epstein MP, McDade E, Barthélemy NR, Karch CM, Xiong C, Cruchaga C, Perrin RJ, ... ... Haass C, et al. Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease. Nature Medicine. PMID 37550416 DOI: 10.1038/s41591-023-02476-4 |
0.344 |
|
| 2023 |
Finze A, Biechele G, Rauchmann BS, Franzmeier N, Palleis C, Katzdobler S, Weidinger E, Guersel S, Schuster S, Harris S, Schmitt J, Beyer L, Gnörich J, Lindner S, Albert NL, ... ... Haass C, et al. Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies. Molecular Psychiatry. PMID 37495886 DOI: 10.1038/s41380-023-02188-8 |
0.543 |
|
| 2023 |
Hipke K, Pitter B, Hruscha A, van Bebber F, Modic M, Bansal V, Lewandowski SA, Orozco D, Edbauer D, Bonn S, Haass C, Pohl U, Montanez E, Schmid B. Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased , and . Frontiers in Cell and Developmental Biology. 11: 1169962. PMID 37384248 DOI: 10.3389/fcell.2023.1169962 |
0.581 |
|
| 2023 |
Gnörich J, Reifschneider A, Wind K, Zatcepin A, Kunte ST, Beumers P, Bartos LM, Wiedemann T, Grosch M, Xiang X, Fard MK, Ruch F, Werner G, Koehler M, Slemann L, ... ... Haass C, et al. Depletion and activation of microglia impact metabolic connectivity of the mouse brain. Journal of Neuroinflammation. 20: 47. PMID 36829182 DOI: 10.1186/s12974-023-02735-8 |
0.588 |
|
| 2023 |
van Lengerich B, Zhan L, Xia D, Chan D, Joy D, Park JI, Tatarakis D, Calvert M, Hummel S, Lianoglou S, Pizzo ME, Prorok R, Thomsen E, Bartos LM, Beumers P, ... ... Haass C, et al. A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models. Nature Neuroscience. PMID 36635496 DOI: 10.1038/s41593-022-01240-0 |
0.523 |
|
| 2023 |
Biel D, Suárez-Calvet M, Hager P, Rubinski A, Dewenter A, Steward A, Roemer S, Ewers M, Haass C, Brendel M, Franzmeier N. sTREM2 is associated with amyloid-related p-tau increases and glucose hypermetabolism in Alzheimer's disease. Embo Molecular Medicine. e16987. PMID 36620941 DOI: 10.15252/emmm.202216987 |
0.568 |
|
| 2022 |
Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, ... ... Haass C, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020 |
0.665 |
|
| 2022 |
Xiang X, Tahirovic S, Ziegler S, Haass C, Brendel M. Response to Comment on "Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases". Science Translational Medicine. 14: eabn5104. PMID 36001676 DOI: 10.1126/scitranslmed.abn5104 |
0.595 |
|
| 2022 |
Haass C, Selkoe D. If amyloid drives Alzheimer disease, why have anti-amyloid therapies not yet slowed cognitive decline? Plos Biology. 20: e3001694. PMID 35862308 DOI: 10.1371/journal.pbio.3001694 |
0.316 |
|
| 2022 |
Xia D, Lianoglou S, Sandmann T, Calvert M, Suh JH, Thomsen E, Dugas J, Pizzo ME, DeVos SL, Earr TK, Lin CC, Davis S, Ha C, Leung AW, Nguyen H, ... ... Haass C, et al. Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia. Molecular Neurodegeneration. 17: 41. PMID 35690868 DOI: 10.1186/s13024-022-00547-7 |
0.537 |
|
| 2022 |
Bartos LM, Kunte ST, Beumers P, Xiang X, Wind K, Ziegler S, Bartenstein P, Choi H, Lee DS, Haass C, von Baumgarten L, Tahirovic S, Albert NL, Lindner S, Brendel M. Single cell radiotracer allocation via immunomagentic sorting (scRadiotracing) to disentangle PET signals at cellular resolution. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 35589403 DOI: 10.2967/jnumed.122.264171 |
0.584 |
|
| 2022 |
Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D. Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons. Embo Reports. e53890. PMID 35438230 DOI: 10.15252/embr.202153890 |
0.624 |
|
| 2022 |
Morenas-Rodríguez E, Li Y, Nuscher B, Franzmeier N, Xiong C, Suárez-Calvet M, Fagan AM, Schultz S, Gordon BA, Benzinger TLS, Hassenstab J, McDade E, Feederle R, Karch CM, Schlepckow K, ... ... Haass C, et al. Soluble TREM2 in CSF and its association with other biomarkers and cognition in autosomal-dominant Alzheimer's disease: a longitudinal observational study. The Lancet. Neurology. 21: 329-341. PMID 35305339 DOI: 10.1016/S1474-4422(22)00027-8 |
0.305 |
|
| 2022 |
Reifschneider A, Robinson S, van Lengerich B, Gnörich J, Logan T, Heindl S, Vogt MA, Weidinger E, Riedl L, Wind K, Zatcepin A, Pesämaa I, Haberl S, Nuscher B, Kleinberger G, ... ... Haass C, et al. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The Embo Journal. e109108. PMID 35019161 DOI: 10.15252/embj.2021109108 |
0.494 |
|
| 2021 |
Joshi P, Riffel F, Kumar S, Villacampa N, Theil S, Parhizkar S, Haass C, Colonna M, Heneka MT, Arzberger T, Herms J, Walter J. TREM2 modulates differential deposition of modified and non-modified Aβ species in extracellular plaques and intraneuronal deposits. Acta Neuropathologica Communications. 9: 168. PMID 34663480 DOI: 10.1186/s40478-021-01263-x |
0.775 |
|
| 2021 |
Xiang X, Wind K, Wiedemann T, Blume T, Shi Y, Briel N, Beyer L, Biechele G, Eckenweber F, Zatcepin A, Lammich S, Ribicic S, Tahirovic S, Willem M, Deussing M, ... ... Haass C, et al. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases. Science Translational Medicine. 13: eabe5640. PMID 34644146 DOI: 10.1126/scitranslmed.abe5640 |
0.591 |
|
| 2021 |
Mori K, Gotoh S, Yamashita T, Uozumi R, Kawabe Y, Tagami S, Kamp F, Nuscher B, Edbauer D, Haass C, Nagai Y, Ikeda M. The porphyrin TMPyP4 inhibits elongation during the non-canonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene. The Journal of Biological Chemistry. 101120. PMID 34450161 DOI: 10.1016/j.jbc.2021.101120 |
0.554 |
|
| 2021 |
Joshi P, Riffel F, Satoh K, Enomoto M, Qamar S, Scheiblich H, Villacampa N, Kumar S, Theil S, Parhizkar S, Haass C, Heneka MT, Fraser PE, St George-Hyslop P, Walter J. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia. PMID 34427354 DOI: 10.1002/glia.24077 |
0.782 |
|
| 2021 |
Vettermann FJ, Harris S, Schmitt J, Unterrainer M, Lindner S, Rauchmann BS, Palleis C, Weidinger E, Beyer L, Eckenweber F, Schuster S, Biechele G, Ferschmann C, Milenkovic VM, Wetzel CH, ... ... Haass C, et al. Impact of TSPO Receptor Polymorphism on [F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders. Life (Basel, Switzerland). 11. PMID 34073557 DOI: 10.3390/life11060484 |
0.457 |
|
| 2021 |
Schmitt J, Palleis C, Sauerbeck J, Unterrainer M, Harris S, Prix C, Weidinger E, Katzdobler S, Wagemann O, Danek A, Beyer L, Rauchmann BS, Rominger A, Simons M, Bartenstein P, ... ... Haass C, et al. Dual-Phase β-Amyloid PET Captures Neuronal Injury and Amyloidosis in Corticobasal Syndrome. Frontiers in Aging Neuroscience. 13: 661284. PMID 34054506 DOI: 10.3389/fnagi.2021.661284 |
0.493 |
|
| 2021 |
Biechele G, Sebastian Monasor L, Wind K, Blume T, Parhizkar S, Arzberger T, Sacher C, Beyer L, Eckenweber F, Gildehaus FJ, von Ungern-Sternberg B, Willem M, Bartenstein P, Cumming P, Rominger A, ... ... Haass C, et al. Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 34016733 DOI: 10.2967/jnumed.120.261858 |
0.798 |
|
| 2021 |
Palleis C, Brendel M, Finze A, Weidinger E, Bötzel K, Danek A, Beyer L, Nitschmann A, Kern M, Biechele G, Rauchmann BS, Häckert J, Höllerhage M, Stephens AW, Drzezga A, ... ... Haass C, et al. Cortical [ F]PI-2620 Binding Differentiates Corticobasal Syndrome Subtypes. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33951244 DOI: 10.1002/mds.28624 |
0.453 |
|
| 2021 |
Haass C. Loss of TREM2 facilitates tau accumulation, spreading, and brain atrophy, but only in the presence of amyloid pathology. Neuron. 109: 1243-1245. PMID 33887187 DOI: 10.1016/j.neuron.2021.03.029 |
0.328 |
|
| 2021 |
Colombo AV, Sadler RK, Llovera G, Singh V, Roth S, Heindl S, Sebastian Monasor L, Verhoeven A, Peters F, Parhizkar S, Kamp F, Gomez de Aguero M, MacPherson AJ, Winkler E, Herms J, ... ... Haass C, et al. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. Elife. 10. PMID 33845942 DOI: 10.7554/eLife.59826 |
0.767 |
|
| 2021 |
Nuebling GS, Prix C, Brendel M, Beyer L, Wlasich E, Loosli SV, Barthel H, Sabri O, Bartenstein P, Vöglein J, Danek A, Rominger A, Edbauer D, Haass C, Levin J. Low-degree trisomy 21 mosaicism promotes early-onset Alzheimer disease. Neurobiology of Aging. PMID 33789815 DOI: 10.1016/j.neurobiolaging.2021.02.021 |
0.718 |
|
| 2020 |
Palleis C, Sauerbeck J, Beyer L, Harris S, Schmitt J, Morenas-Rodriguez E, Finze A, Nitschmann A, Ruch-Rubinstein F, Eckenweber F, Biechele G, Blume T, Shi Y, Weidinger E, Prix C, ... ... Haass C, et al. In Vivo Assessment of Neuroinflammation in 4-Repeat Tauopathies. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33245166 DOI: 10.1002/mds.28395 |
0.437 |
|
| 2020 |
Franzmeier N, Suárez-Calvet M, Frontzkowski L, Moore A, Hohman TJ, Morenas-Rodriguez E, Nuscher B, Shaw L, Trojanowski JQ, Dichgans M, Kleinberger G, Haass C, Ewers M. Higher CSF sTREM2 attenuates ApoE4-related risk for cognitive decline and neurodegeneration. Molecular Neurodegeneration. 15: 57. PMID 33032659 DOI: 10.1186/s13024-020-00407-2 |
0.389 |
|
| 2020 |
Werner G, Damme M, Schludi M, Gnörich J, Wind K, Fellerer K, Wefers B, Wurst W, Edbauer D, Brendel M, Haass C, Capell A. Loss of TMEM106B potentiates lysosomal and FTLD-like pathology in progranulin-deficient mice. Embo Reports. e50241. PMID 32929860 DOI: 10.15252/Embr.202050241 |
0.72 |
|
| 2020 |
Takalo M, Wittrahm R, Wefers B, Parhizkar S, Jokivarsi K, Kuulasmaa T, Mäkinen P, Martiskainen H, Wurst W, Xiang X, Marttinen M, Poutiainen P, Haapasalo A, Hiltunen M, Haass C. The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions. Molecular Neurodegeneration. 15: 52. PMID 32917267 DOI: 10.1186/S13024-020-00402-7 |
0.799 |
|
| 2020 |
Steiner A, Schlepckow K, Brunner B, Steiner H, Haass C, Hagn F. γ-Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics. The Embo Journal. e104247. PMID 32830336 DOI: 10.15252/Embj.2019104247 |
0.332 |
|
| 2020 |
Ewers M, Biechele G, Suárez-Calvet M, Sacher C, Blume T, Morenas-Rodriguez E, Deming Y, Piccio L, Cruchaga C, Kleinberger G, Shaw L, Trojanowski JQ, Herms J, Dichgans M, ... ... Haass C, et al. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. Embo Molecular Medicine. e12308. PMID 32790063 DOI: 10.15252/Emmm.202012308 |
0.786 |
|
| 2020 |
Sebastian Monasor L, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models. Elife. 9. PMID 32510331 DOI: 10.7554/Elife.54083 |
0.442 |
|
| 2020 |
Sacher C, Blume T, Beyer L, Biechele G, Sauerbeck J, Eckenweber F, Deussing M, Focke C, Parhizkar S, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Baumann K, Tahirovic S, Kleinberger G, ... ... Haass C, et al. Asymmetry of fibrillar plaque burden in amyloid mouse models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32414948 DOI: 10.2967/Jnumed.120.242750 |
0.809 |
|
| 2020 |
Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C. Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32237095 DOI: 10.1096/Fj.201902183R |
0.327 |
|
| 2020 |
Schlepckow K, Monroe KM, Kleinberger G, Cantuti-Castelvetri L, Parhizkar S, Xia D, Willem M, Werner G, Pettkus N, Brunner B, Sülzen A, Nuscher B, Hampel H, Xiang X, Feederle R, ... ... Haass C, et al. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. Embo Molecular Medicine. e11227. PMID 32154671 DOI: 10.15252/Emmm.201911227 |
0.793 |
|
| 2020 |
Monasor LS, Müller SA, Colombo AV, Tanrioever G, König J, Roth S, Liesz A, Berghofer A, Piechotta A, Prestel M, Saito T, Saido TC, Herms J, Willem M, Haass C, et al. Author response: Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models Elife. DOI: 10.7554/Elife.54083.Sa2 |
0.39 |
|
| 2019 |
Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, et al. Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. Embo Molecular Medicine. e10919. PMID 31858749 DOI: 10.15252/Emmm.201910919 |
0.762 |
|
| 2019 |
Nihei Y, Mori K, Werner G, Arzberger T, Zhou Q, Khosravi B, Japtok J, Hermann A, Sommacal A, Weber M, Kamp F, Nuscher B, Edbauer D, ... Haass C, et al. Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3. Acta Neuropathologica. PMID 31642962 DOI: 10.1007/S00401-019-02082-0 |
0.583 |
|
| 2019 |
Vöglein J, Willem M, Trambauer J, Schönecker S, Dieterich M, Biskup S, Giudici C, Utz K, Oberstein T, Brendel M, Rominger A, Danek A, Steiner H, Haass C, Levin J. Identification of a rare presenilin 1 single amino acid deletion mutation (F175del) with unusual amyloid-β processing effects. Neurobiology of Aging. PMID 31627977 DOI: 10.1016/J.Neurobiolaging.2019.08.034 |
0.599 |
|
| 2019 |
Jessen F, Haass C. [Quo vadis Alzheimer?] Der Nervenarzt. 90: 881-883. PMID 31493046 DOI: 10.1007/S00115-019-0771-X |
0.401 |
|
| 2019 |
Ewers M, Franzmeier N, Suárez-Calvet M, Morenas-Rodriguez E, Caballero MAA, Kleinberger G, Piccio L, Cruchaga C, Deming Y, Dichgans M, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science Translational Medicine. 11. PMID 31462511 DOI: 10.1126/Scitranslmed.Aav6221 |
0.715 |
|
| 2019 |
Deming Y, Filipello F, Cignarella F, Cantoni C, Hsu S, Mikesell R, Li Z, Del-Aguila JL, Dube U, Farias FG, Bradley J, Budde J, Ibanez L, Fernandez MV, Blennow K, ... ... Haass C, et al. The gene cluster is a key modulator of soluble TREM2 and Alzheimer's disease risk. Science Translational Medicine. 11. PMID 31413141 DOI: 10.1126/Scitranslmed.Aau2291 |
0.704 |
|
| 2019 |
Haass C, Levin J. [Did Alzheimer research fail entirely? : Failure of amyloid-based clinical studies]. Der Nervenarzt. PMID 31243509 DOI: 10.1007/S00115-019-0751-1 |
0.446 |
|
| 2019 |
Morenas-Rodríguez E, Alcolea D, Suárez-Calvet M, Muñoz-Llahuna L, Vilaplana E, Sala I, Subirana A, Querol-Vilaseca M, Carmona-Iragui M, Illán-Gala I, Ribosa-Nogué R, Blesa R, Haass C, Fortea J, Lleó A. Different pattern of CSF glial markers between dementia with Lewy bodies and Alzheimer's disease. Scientific Reports. 9: 7803. PMID 31127154 DOI: 10.1038/S41598-019-44173-8 |
0.372 |
|
| 2019 |
Götzl JK, Brendel M, Werner G, Parhizkar S, Sebastian Monasor L, Kleinberger G, Colombo AV, Deussing M, Wagner M, Winkelmann J, Diehl-Schmid J, Levin J, Fellerer K, Reifschneider A, Bultmann S, ... ... Haass C, et al. Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism. Embo Molecular Medicine. PMID 31122931 DOI: 10.15252/Emmm.201809711 |
0.796 |
|
| 2019 |
Katzmarski N, Ziegler-Waldkirch S, Scheffler N, Witt C, Abou-Ajram C, Nuscher B, Prinz M, Haass C, Meyer-Luehmann M. Aβ oligomers trigger and accelerate Aβ seeding. Brain Pathology (Zurich, Switzerland). PMID 31099449 DOI: 10.1111/Bpa.12734 |
0.424 |
|
| 2019 |
Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, ... ... Haass C, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/S41380-019-0404-6 |
0.365 |
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| 2019 |
Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... ... Haass C, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/Brain/Awz050 |
0.346 |
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| 2019 |
van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, ... ... Haass C, et al. A protein quality control pathway regulated by linear ubiquitination. The Embo Journal. PMID 30886048 DOI: 10.15252/Embj.2018100730 |
0.365 |
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| 2019 |
Haass C, Willem M. Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention? Neuron. 101: 557-559. PMID 30790537 DOI: 10.1016/J.Neuron.2019.01.058 |
0.376 |
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| 2019 |
Suárez-Calvet M, Morenas-Rodríguez E, Kleinberger G, Schlepckow K, Caballero MÁA, Franzmeier N, Capell A, Fellerer K, Nuscher B, Eren E, Levin J, Deming Y, Piccio L, Karch CM, Cruchaga C, ... ... Haass C, et al. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular Neurodegeneration. 14: 1. PMID 30630532 DOI: 10.1186/S13024-018-0301-5 |
0.744 |
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| 2019 |
Parhizkar S, Arzberger T, Brendel M, Kleinberger G, Deussing M, Focke C, Nuscher B, Xiong M, Ghasemigharagoz A, Katzmarski N, Krasemann S, Lichtenthaler SF, Müller SA, Colombo A, Monasor LS, ... ... Haass C, et al. Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Nature Neuroscience. PMID 30617257 DOI: 10.1038/S41593-018-0296-9 |
0.814 |
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| 2019 |
Eninger T, Müller SA, Bacioglu M, Schweighauser M, Maia LF, Lambert M, Kleinberger G, Haass C, Kahle PJ, Staufenbiel M, Lichtenthaler S, Jucker M, Kaeser SA. P4-544: Deep Proteome Analysis In Cerebrospinal Fluid Of Mouse Models For Neurodegenerative Diseases Suggests A Panel Of Novel Biomarkers Related To Microglia Activation Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.08.091 |
0.317 |
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| 2019 |
Ewers M, Franzmeier N, Suárez-Calvet M, Morenas E, Piccio L, Cruchaga C, Robles Y, Trojanowski JQ, Shaw LM, Weiner MW, Haass C. O3-12-05: Increased Csf Soluble Trem2 Is Associated With Ameliorated Longitudinal Cognitive And Clinical Decline In Alzheimer'S Disease Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4694 |
0.432 |
|
| 2018 |
Suárez-Calvet M, Capell A, Araque Caballero MÁ, Morenas-Rodríguez E, Fellerer K, Franzmeier N, Kleinberger G, Eren E, Deming Y, Piccio L, Karch CM, Cruchaga C, Paumier K, Bateman RJ, Fagan AM, ... ... Haass C, et al. CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline. Embo Molecular Medicine. PMID 30482868 DOI: 10.15252/Emmm.201809712 |
0.735 |
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| 2018 |
Brendel M, Jaworska A, Overhoff F, Blume T, Probst F, Gildehaus FJ, Bartenstein P, Haass C, Bohrmann B, Herms J, Willem M, Rominger A. Efficacy of chronic BACE1 inhibition in PS2APP mice depends on the regional Aβ deposition rate and plaque burden at treatment initiation. Theranostics. 8: 4957-4968. PMID 30429879 DOI: 10.7150/Thno.27868 |
0.593 |
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| 2018 |
Focke C, Blume T, Zott B, Yuan Shi Y, Deussing M, Peters F, Schmidt C, Kleinberger G, Lindner S, Gildehaus FJ, Beyer L, von Ungern-Sternberg B, Bartenstein P, Ozmen L, Baumann K, ... ... Haass C, et al. Early and longitudinal microglial activation but not amyloid accumulation predict cognitive outcome in PS2APP mice. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30262517 DOI: 10.2967/Jnumed.118.217703 |
0.555 |
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| 2018 |
Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, ... ... Haass C, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/Brain/Awy229 |
0.344 |
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| 2018 |
Xiang X, Piers TM, Wefers B, Zhu K, Mallach A, Brunner B, Kleinberger G, Song W, Colonna M, Herms J, Wurst W, Pocock JM, Haass C. The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans. Molecular Neurodegeneration. 13: 49. PMID 30185230 DOI: 10.1186/S13024-018-0280-6 |
0.581 |
|
| 2018 |
Götzl JK, Colombo AV, Fellerer K, Reifschneider A, Werner G, Tahirovic S, Haass C, Capell A. Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice. Molecular Neurodegeneration. 13: 48. PMID 30180904 DOI: 10.1186/S13024-018-0281-5 |
0.382 |
|
| 2018 |
Brendel M, Yousefi BH, Blume T, Herz M, Focke C, Deussing M, Peters F, Lindner S, von Ungern-Sternberg B, Drzezga A, Bartenstein P, Haass C, Okamura N, Herms J, Yakushev I, et al. Comparison of F-T807 and F-THK5117 PET in a Mouse Model of Tau Pathology. Frontiers in Aging Neuroscience. 10: 174. PMID 29930508 DOI: 10.3389/Fnagi.2018.00174 |
0.533 |
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| 2018 |
Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain. Acta Neuropathologica. PMID 29687257 DOI: 10.1007/S00401-018-1846-7 |
0.628 |
|
| 2018 |
Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a Journal of Neurology. PMID 29462334 DOI: 10.1093/Brain/Awy008 |
0.35 |
|
| 2017 |
Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, Beckers L, O'Loughlin E, Xu Y, Fanek Z, Greco DJ, Smith ST, Tweet G, Humulock Z, Zrzavy T, ... ... Haass C, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 47: 566-581.e9. PMID 28930663 DOI: 10.1016/J.Immuni.2017.08.008 |
0.679 |
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| 2017 |
Schlepckow K, Kleinberger G, Fukumori A, Feederle R, Lichtenthaler SF, Steiner H, Haass C. An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function. Embo Molecular Medicine. PMID 28855300 DOI: 10.15252/Emmm.201707672 |
0.39 |
|
| 2017 |
Blauwendraat C, Wilke C, Simón-Sánchez J, Jansen IE, Reifschneider A, Capell A, Haass C, Castillo-Lizardo M, Biskup S, Maetzler W, Rizzu P, Heutink P, Synofzik M. The wide genetic landscape of clinical frontotemporal dementia: systematic combined sequencing of 121 consecutive subjects. Genetics in Medicine : Official Journal of the American College of Medical Genetics. PMID 28749476 DOI: 10.1038/Gim.2017.102 |
0.307 |
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| 2017 |
Brendel M, Focke C, Blume T, Peters F, Deussing M, Probst F, Jaworska A, Overhoff F, Albert N, Lindner S, von Ungern-Sternberg B, Bartenstein P, Haass C, Kleinberger G, Herms J, et al. Time Courses of Cortical Glucose Metabolism and Microglial Activity Across the Life-Span of Wild-Type Mice: A PET Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28705919 DOI: 10.2967/Jnumed.117.195107 |
0.517 |
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| 2017 |
Kleinberger G, Brendel M, Mracsko E, Wefers B, Groeneweg L, Xiang X, Focke C, Deußing M, Suárez-Calvet M, Mazaheri F, Parhizkar S, Pettkus N, Wurst W, Feederle R, Bartenstein P, ... ... Haass C, et al. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The Embo Journal. PMID 28559417 DOI: 10.15252/Embj.201796516 |
0.795 |
|
| 2017 |
Mazaheri F, Snaidero N, Kleinberger G, Madore C, Daria A, Werner G, Krasemann S, Capell A, Trümbach D, Wurst W, Brunner B, Bultmann S, Tahirovic S, Kerschensteiner M, Misgeld T, ... ... Haass C, et al. TREM2 deficiency impairs chemotaxis and microglial responses to neuronal injury. Embo Reports. PMID 28483841 DOI: 10.15252/Embr.201743922 |
0.369 |
|
| 2017 |
Zhou Q, Lehmer C, Michaelsen M, Mori K, Alterauge D, Baumjohann D, Schludi MH, Greiling J, Farny D, Flatley A, Feederle R, May S, Schreiber F, Arzberger T, Kuhm C, ... ... Haass C, et al. Antibodies inhibit transmission and aggregation of C9orf72 poly-GA dipeptide repeat proteins. Embo Molecular Medicine. PMID 28351931 DOI: 10.15252/Emmm.201607054 |
0.621 |
|
| 2017 |
Brendel M, Kleinberger G, Probst F, Jaworska A, Overhoff F, Blume T, Albert NL, Carlsen J, Lindner S, Gildehaus FJ, Ozmen L, Suárez-Calvet M, Bartenstein P, Baumann K, Ewers M, ... ... Haass C, et al. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Frontiers in Aging Neuroscience. 9: 8. PMID 28197095 DOI: 10.3389/Fnagi.2017.00008 |
0.602 |
|
| 2017 |
Gispert JD, Monté GC, Suárez-Calvet M, Falcon C, Tucholka A, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2. Alzheimer's & Dementia (Amsterdam, Netherlands). 6: 50-59. PMID 28149943 DOI: 10.1016/J.Dadm.2016.12.002 |
0.366 |
|
| 2017 |
Ohki Y, Wenninger-Weinzierl A, Hruscha A, Asakawa K, Kawakami K, Haass C, Edbauer D, Schmid B. Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration. Molecular Neurodegeneration. 12: 6. PMID 28088213 DOI: 10.1186/S13024-016-0146-8 |
0.626 |
|
| 2017 |
Haass C. BIOLOGICAL ACTIONS OF TREM2 IN ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P1447. DOI: 10.1016/J.Jalz.2017.07.485 |
0.351 |
|
| 2016 |
Zhu K, Xiang X, Filser S, Marinković P, Dorostkar MM, Crux S, Neumann U, Shimshek DR, Rammes G, Haass C, Lichtenthaler SF, Gunnersen JM, Herms J. Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6. Biological Psychiatry. PMID 28129943 DOI: 10.1016/J.Biopsych.2016.12.023 |
0.582 |
|
| 2016 |
Daria A, Colombo A, Llovera G, Hampel H, Willem M, Liesz A, Haass C, Tahirovic S. Young microglia restore amyloid plaque clearance of aged microglia. The Embo Journal. PMID 28007893 DOI: 10.15252/Embj.201694591 |
0.436 |
|
| 2016 |
Suárez-Calvet M, Araque Caballero MÁ, Kleinberger G, Bateman RJ, Fagan AM, Morris JC, Levin J, Danek A, Ewers M, Haass C. Early changes in CSF sTREM2 in dominantly inherited Alzheimer's disease occur after amyloid deposition and neuronal injury. Science Translational Medicine. 8: 369ra178. PMID 27974666 DOI: 10.1126/Scitranslmed.Aag1767 |
0.389 |
|
| 2016 |
Haass C, Neumann M. Frontotemporal dementia: from molecular mechanisms to therapy. Journal of Neurochemistry. 138: 3-5. PMID 27502123 DOI: 10.1111/Jnc.13619 |
0.323 |
|
| 2016 |
Mori K, Nihei Y, Arzberger T, Zhou Q, Mackenzie IR, Hermann A, Hanisch F, Kamp F, Nuscher B, Orozco D, Edbauer D, Haass C. Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition. Embo Reports. PMID 27461252 DOI: 10.15252/Embr.201541724 |
0.6 |
|
| 2016 |
Gispert JD, Suárez-Calvet M, Monté GC, Tucholka A, Falcon C, Rojas S, Rami L, Sánchez-Valle R, Lladó A, Kleinberger G, Haass C, Molinuevo JL. Cerebrospinal fluid sTREM2 levels are associated with gray matter volume increases and reduced diffusivity in early Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27423963 DOI: 10.1016/J.Jalz.2016.06.005 |
0.369 |
|
| 2016 |
Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, Capell A, Feederle R, Knuesel I, Kleinberger G, Haass C. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. Embo Molecular Medicine. PMID 27402340 DOI: 10.15252/Emmm.201606370 |
0.604 |
|
| 2016 |
Götzl JK, Lang CM, Haass C, Capell A. Impaired protein degradation in FTLD and related disorders. Ageing Research Reviews. PMID 27166223 DOI: 10.1016/J.Arr.2016.04.008 |
0.411 |
|
| 2016 |
Kretner B, Trambauer J, Fukumori A, Mielke J, Kuhn PH, Kremmer E, Giese A, Lichtenthaler SF, Haass C, Arzberger T, Steiner H. Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease. Embo Molecular Medicine. PMID 26988102 DOI: 10.15252/Emmm.201505952 |
0.468 |
|
| 2016 |
Overhoff F, Brendel M, Jaworska A, Korzhova V, Delker A, Probst F, Focke C, Gildehaus FJ, Carlsen J, Baumann K, Haass C, Bartenstein P, Herms J, Rominger A. Automated Spatial Brain Normalization and Hindbrain White Matter Reference Tissue Give Improved [(18)F]-Florbetaben PET Quantitation in Alzheimer's Model Mice. Frontiers in Neuroscience. 10: 45. PMID 26973442 DOI: 10.3389/Fnins.2016.00045 |
0.546 |
|
| 2016 |
Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, ... ... Haass C, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. Embo Molecular Medicine. PMID 26941262 DOI: 10.15252/Emmm.201506123 |
0.589 |
|
| 2016 |
Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L. Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein. Cell Reports. 14: 2127-41. PMID 26923602 DOI: 10.1016/J.Celrep.2016.01.076 |
0.393 |
|
| 2016 |
Brendel M, Jaworska A, Probst F, Overhoff F, Korzhova V, Lindner S, Carlsen J, Bartenstein P, Harada R, Kudo Y, Haass C, van Leuven F, Okamura N, Herms J, Rominger A. microPET Imaging of Tau Pathology with [18F]-THK5117 in two Transgenic Mouse Models. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912432 DOI: 10.2967/Jnumed.115.163493 |
0.551 |
|
| 2016 |
Brendel M, Probst F, Jaworska A, Overhoff F, Korzhova V, Albert N, Beck R, Lindner S, Gildehaus FJ, Baumann K, Bartenstein P, Kleinberger G, Haass C, Herms J, Rominger A. Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple Tracer PET Study. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 26912428 DOI: 10.2967/Jnumed.115.167858 |
0.591 |
|
| 2016 |
Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, ... ... Haass C, et al. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathologica. PMID 26895297 DOI: 10.1007/S00401-016-1544-2 |
0.613 |
|
| 2016 |
Busche MA, Staufenbiel M, Willem M, Haass C, Förstl H. [Mechanisms of Alzheimer's disease : Neuronal hyperactivity and hypoactivity as new therapeutic targets]. Der Nervenarzt. PMID 26781314 DOI: 10.1007/S00115-015-0041-5 |
0.465 |
|
| 2016 |
Ewers M, Suarez-Calvet M, Caballero MAA, Kleinberger G, Fagan AM, Moulder KL, Benzinger TLS, Haass C. Csf Levels Of Strem2 Are Associated With Greater Frontal Cortical Thickness During Advanced Disease Stages In Autosomal Dominant Alzheimer Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.145 |
0.329 |
|
| 2015 |
Kleinberger G, Capell A, Brouwers N, Fellerer K, Sleegers K, Cruts M, Van Broeckhoven C, Haass C. Reduced secretion and altered proteolytic processing caused by missense mutations in progranulin. Neurobiology of Aging. PMID 26811050 DOI: 10.1016/J.Neurobiolaging.2015.12.014 |
0.317 |
|
| 2015 |
Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröeper M, Rossner MJ, Fluhrer R, Willem M, Haass C. Proteolytic processing of Neuregulin 1 type III by three intramembrane cleaving proteases. The Journal of Biological Chemistry. PMID 26574544 DOI: 10.1074/Jbc.M115.697995 |
0.635 |
|
| 2015 |
Janssens J, Philtjens S, Kleinberger G, Van Mossevelde S, van der Zee J, Cacace R, Engelborghs S, Sieben A, Banzhaf-Strathmann J, Dillen L, Merlin C, Cuijt I, Robberecht C, Schmid B, Santens P, ... ... Haass C, et al. Investigating the role of filamin C in Belgian patients with frontotemporal dementia linked to GRN deficiency in FTLD-TDP brains. Acta Neuropathologica Communications. 3: 68. PMID 26555887 DOI: 10.1186/S40478-015-0246-7 |
0.332 |
|
| 2015 |
Edbauer D, Haass C. An amyloid-like cascade hypothesis for C9orf72 ALS/FTD. Current Opinion in Neurobiology. 36: 99-106. PMID 26555807 DOI: 10.1016/J.Conb.2015.10.009 |
0.656 |
|
| 2015 |
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Monitoring of chronic γ-secretase modulator treatment by serial amyloid-PET. Molecular Psychiatry. 20: 1141. PMID 26401838 DOI: 10.1038/mp.2015.146 |
0.481 |
|
| 2015 |
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, ... ... Haass C, et al. η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature. PMID 26322584 DOI: 10.1038/Nature14864 |
0.394 |
|
| 2015 |
Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887 |
0.596 |
|
| 2015 |
Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nature Medicine. 21: 802-7. PMID 26099047 DOI: 10.1038/Nm.3885 |
0.403 |
|
| 2015 |
Kuhn PH, Voss M, Haug-Kröper M, Schröder B, Schepers U, Bräse S, Haass C, Lichtenthaler SF, Fluhrer R. Secretome analysis identifies novel signal Peptide peptidase-like 3 (sppl3) substrates and reveals a role of sppl3 in multiple Golgi glycosylation pathways. Molecular & Cellular Proteomics : McP. 14: 1584-98. PMID 25827571 DOI: 10.1074/Mcp.M115.048298 |
0.312 |
|
| 2015 |
Solchenberger B, Russell C, Kremmer E, Haass C, Schmid B. Granulin knock out zebrafish lack frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis pathology. Plos One. 10: e0118956. PMID 25785851 DOI: 10.1371/Journal.Pone.0118956 |
0.324 |
|
| 2015 |
Brendel M, Jaworska A, Grießinger E, Rötzer C, Burgold S, Gildehaus FJ, Carlsen J, Cumming P, Baumann K, Haass C, Steiner H, Bartenstein P, Herms J, Rominger A. Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models. Plos One. 10: e0116678. PMID 25706990 DOI: 10.1371/Journal.Pone.0116678 |
0.549 |
|
| 2015 |
Schulte EC, Fukumori A, Mollenhauer B, Hor H, Arzberger T, Perneczky R, Kurz A, Diehl-Schmid J, Hüll M, Lichtner P, Eckstein G, Zimprich A, Haubenberger D, Pirker W, Brücke T, ... ... Haass C, et al. Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease. European Journal of Human Genetics : Ejhg. PMID 25604855 DOI: 10.1038/Ejhg.2014.300 |
0.319 |
|
| 2015 |
Jäckel S, Summerer AK, Thömmes CM, Pan X, Voigt A, Schulz JB, Rasse TM, Dormann D, Haass C, Kahle PJ. Nuclear import factor transportin and arginine methyltransferase 1 modify FUS neurotoxicity in Drosophila. Neurobiology of Disease. 74: 76-88. PMID 25447237 DOI: 10.1016/J.Nbd.2014.11.003 |
0.37 |
|
| 2015 |
Brendel M, Jaworska A, Herms J, Trambauer J, Rötzer C, Gildehaus FJ, Carlsen J, Cumming P, Bylund J, Luebbers T, Bartenstein P, Steiner H, Haass C, Baumann K, Rominger A. Amyloid-PET predicts inhibition of de novo plaque formation upon chronic γ-secretase modulator treatment Molecular Psychiatry. DOI: 10.1038/mp.2015.74 |
0.495 |
|
| 2014 |
Voss M, Künzel U, Higel F, Kuhn PH, Colombo A, Fukumori A, Haug-Kröper M, Klier B, Grammer G, Seidl A, Schröder B, Obst R, Steiner H, Lichtenthaler SF, Haass C, et al. Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation. The Embo Journal. 33: 2890-905. PMID 25354954 DOI: 10.15252/Embj.201488375 |
0.308 |
|
| 2014 |
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, ... ... Haass C, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. 6: 243ra86. PMID 24990881 DOI: 10.1126/Scitranslmed.3009093 |
0.386 |
|
| 2014 |
Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/Jnc.12715 |
0.424 |
|
| 2014 |
Götzl JK, Mori K, Damme M, Fellerer K, Tahirovic S, Kleinberger G, Janssens J, van der Zee J, Lang CM, Kremmer E, Martin JJ, Engelborghs S, Kretzschmar HA, Arzberger T, Van Broeckhoven C, ... Haass C, et al. Common pathobiochemical hallmarks of progranulin-associated frontotemporal lobar degeneration and neuronal ceroid lipofuscinosis. Acta Neuropathologica. 127: 845-60. PMID 24619111 DOI: 10.1007/S00401-014-1262-6 |
0.38 |
|
| 2014 |
Schwenk BM, Lang CM, Hogl S, Tahirovic S, Orozco D, Rentzsch K, Lichtenthaler SF, Hoogenraad CC, Capell A, Haass C, Edbauer D. The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes. The Embo Journal. 33: 450-67. PMID 24357581 DOI: 10.1002/Embj.201385857 |
0.586 |
|
| 2014 |
Liebscher S, Page RM, Käfer K, Winkler E, Quinn K, Goldbach E, Brigham EF, Quincy D, Basi GS, Schenk DB, Steiner H, Bonhoeffer T, Haass C, Meyer-Luehmann M, Hübener M. Chronic γ-secretase inhibition reduces amyloid plaque-associated instability of pre- and postsynaptic structures. Molecular Psychiatry. 19: 937-46. PMID 24061497 DOI: 10.1038/Mp.2013.122 |
0.437 |
|
| 2014 |
Brendel M, Delker A, Rötzer C, Böning G, Carlsen J, Cyran C, Mille E, Gildehaus FJ, Cumming P, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A. Impact of partial volume effect correction on cerebral β-amyloid imaging in APP-Swe mice using [(18)F]-florbetaben PET. Neuroimage. 84: 843-53. PMID 24055703 DOI: 10.1016/J.Neuroimage.2013.09.017 |
0.57 |
|
| 2014 |
Rominger A, Brendel M, Rötzer C, Gildehaus F, Baumann K, Haass C, Steiner H, Herms J, Bartenstein P. Monitoring Of Long-Term Gamma Secretase Modulation Treatment In App-Swe Mice By Means Of [18F]-Florbetaben Pet Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.04.113 |
0.51 |
|
| 2013 |
Mori K, Arzberger T, Grässer FA, Gijselinck I, May S, Rentzsch K, Weng SM, Schludi MH, van der Zee J, Cruts M, Van Broeckhoven C, Kremmer E, Kretzschmar HA, Haass C, Edbauer D. Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathologica. 126: 881-93. PMID 24132570 DOI: 10.1007/S00401-013-1189-3 |
0.624 |
|
| 2013 |
Mackenzie IR, Arzberger T, Kremmer E, Troost D, Lorenzl S, Mori K, Weng SM, Haass C, Kretzschmar HA, Edbauer D, Neumann M. Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathologica. 126: 859-79. PMID 24096617 DOI: 10.1007/S00401-013-1181-Y |
0.633 |
|
| 2013 |
Panda SK, Wefers B, Ortiz O, Floss T, Schmid B, Haass C, Wurst W, Kühn R. Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 195: 703-13. PMID 23979585 DOI: 10.1534/Genetics.113.156570 |
0.313 |
|
| 2013 |
Cheret C, Willem M, Fricker FR, Wende H, Wulf-Goldenberg A, Tahirovic S, Nave KA, Saftig P, Haass C, Garratt AN, Bennett DL, Birchmeier C. Bace1 and Neuregulin-1 cooperate to control formation and maintenance of muscle spindles. The Embo Journal. 32: 2015-28. PMID 23792428 DOI: 10.1038/Emboj.2013.146 |
0.316 |
|
| 2013 |
McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathologica. 126: 179-88. PMID 23775142 DOI: 10.1007/S00401-013-1137-2 |
0.406 |
|
| 2013 |
Rominger A, Brendel M, Burgold S, Keppler K, Baumann K, Xiong G, Mille E, Gildehaus FJ, Carlsen J, Schlichtiger J, Niedermoser S, Wängler B, Cumming P, Steiner H, Herms J, ... Haass C, et al. Longitudinal assessment of cerebral β-amyloid deposition in mice overexpressing Swedish mutant β-amyloid precursor protein using 18F-florbetaben PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 54: 1127-34. PMID 23729696 DOI: 10.2967/Jnumed.112.114660 |
0.59 |
|
| 2013 |
Fleck D, van Bebber F, Colombo A, Galante C, Schwenk BM, Rabe L, Hampel H, Novak B, Kremmer E, Tahirovic S, Edbauer D, Lichtenthaler SF, Schmid B, Willem M, Haass C. Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7856-69. PMID 23637177 DOI: 10.1523/Jneurosci.3372-12.2013 |
0.622 |
|
| 2013 |
Bentmann E, Haass C, Dormann D. Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. The Febs Journal. 280: 4348-70. PMID 23587065 DOI: 10.1111/Febs.12287 |
0.343 |
|
| 2013 |
Dormann D, Haass C. Fused in sarcoma (FUS): an oncogene goes awry in neurodegeneration. Molecular and Cellular Neurosciences. 56: 475-86. PMID 23557964 DOI: 10.1016/J.Mcn.2013.03.006 |
0.334 |
|
| 2013 |
Schmid B, Hruscha A, Hogl S, Banzhaf-Strathmann J, Strecker K, van der Zee J, Teucke M, Eimer S, Hegermann J, Kittelmann M, Kremmer E, Cruts M, Solchenberger B, Hasenkamp L, van Bebber F, ... ... Haass C, et al. Loss of ALS-associated TDP-43 in zebrafish causes muscle degeneration, vascular dysfunction, and reduced motor neuron axon outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 110: 4986-91. PMID 23457265 DOI: 10.1073/Pnas.1218311110 |
0.612 |
|
| 2013 |
Hogl S, van Bebber F, Dislich B, Kuhn PH, Haass C, Schmid B, Lichtenthaler SF. Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains. Proteomics. 13: 1519-27. PMID 23457027 DOI: 10.1002/Pmic.201200582 |
0.388 |
|
| 2013 |
van Bebber F, Hruscha A, Willem M, Schmid B, Haass C. Loss of Bace2 in zebrafish affects melanocyte migration and is distinct from Bace1 knock out phenotypes. Journal of Neurochemistry. 127: 471-81. PMID 23406323 DOI: 10.1111/Jnc.12198 |
0.463 |
|
| 2013 |
Mori K, Weng SM, Arzberger T, May S, Rentzsch K, Kremmer E, Schmid B, Kretzschmar HA, Cruts M, Van Broeckhoven C, Haass C, Edbauer D. The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (New York, N.Y.). 339: 1335-8. PMID 23393093 DOI: 10.1126/Science.1232927 |
0.623 |
|
| 2013 |
Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathologica. 125: 413-23. PMID 23381195 DOI: 10.1007/S00401-013-1088-7 |
0.614 |
|
| 2013 |
Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH. FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy. Plos One. 8: e55243. PMID 23372841 DOI: 10.1371/Journal.Pone.0055243 |
0.354 |
|
| 2013 |
Kleinberger G, Capell A, Haass C, Van Broeckhoven C. Mechanisms of granulin deficiency: lessons from cellular and animal models. Molecular Neurobiology. 47: 337-60. PMID 23239020 DOI: 10.1007/S12035-012-8380-8 |
0.343 |
|
| 2013 |
Kretner B, Fukumori A, Kuhn PH, Pérez-Revuelta BI, Lichtenthaler SF, Haass C, Steiner H. Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. Journal of Neurochemistry. 125: 144-56. PMID 23237322 DOI: 10.1111/Jnc.12124 |
0.382 |
|
| 2013 |
Haass C. The biological function of β-secretase Molecular Neurodegeneration. 8: O5. DOI: 10.1186/1750-1326-8-S1-O5 |
0.336 |
|
| 2013 |
Bachhuber T, McCarter J, Tahirovic S, Nuscher B, Kamp F, Abou-Ajram C, Serrano-Pozo A, Hyman B, Haass C, Meyer-Luehmann M. Cross-inhibition of beta-amyloid plaque formation by alpha-synuclein Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1398 |
0.36 |
|
| 2013 |
Brendel M, Böning G, Delker A, Rötzer C, Gildehaus F, Baumann K, Steiner H, Haass C, Herms J, Bartenstein P, Rominger A. PET imaging using [18F]florbetaben in Alzheimer's disease mouse models Alzheimers & Dementia. 9: 29. DOI: 10.1016/J.Jalz.2013.05.041 |
0.54 |
|
| 2013 |
Haass C, van Bebber F, Hruscha A, Willem M, Schmid B. O1-08-05: Distinct functions of BACE1 and BACE2 in neuregulin processing and melanocyte migration Alzheimer's & Dementia. 9: P144-P144. DOI: 10.1016/J.Jalz.2013.04.096 |
0.381 |
|
| 2012 |
Page RM, Münch A, Horn T, Kuhn PH, Colombo A, Reiner O, Boutros M, Steiner H, Lichtenthaler SF, Haass C. Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 18204-14. PMID 23238734 DOI: 10.1523/Jneurosci.2681-12.2012 |
0.446 |
|
| 2012 |
Voss M, Fukumori A, Kuhn PH, Künzel U, Klier B, Grammer G, Haug-Kröper M, Kremmer E, Lichtenthaler SF, Steiner H, Schröder B, Haass C, Fluhrer R. Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3). The Journal of Biological Chemistry. 287: 43401-9. PMID 23132852 DOI: 10.1074/Jbc.M112.371369 |
0.309 |
|
| 2012 |
Wils H, Kleinberger G, Pereson S, Janssens J, Capell A, Van Dam D, Cuijt I, Joris G, De Deyn PP, Haass C, Van Broeckhoven C, Kumar-Singh S. Cellular ageing, increased mortality and FTLD-TDP-associated neuropathology in progranulin knockout mice. The Journal of Pathology. 228: 67-76. PMID 22733568 DOI: 10.1002/Path.4043 |
0.319 |
|
| 2012 |
Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. The Embo Journal. 31: 3157-68. PMID 22728825 DOI: 10.1038/Emboj.2012.173 |
0.347 |
|
| 2012 |
Orozco D, Tahirovic S, Rentzsch K, Schwenk BM, Haass C, Edbauer D. Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. Embo Reports. 13: 759-64. PMID 22710833 DOI: 10.1038/Embor.2012.90 |
0.653 |
|
| 2012 |
Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D, Haass C. Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). The Journal of Biological Chemistry. 287: 23079-94. PMID 22563080 DOI: 10.1074/Jbc.M111.328757 |
0.304 |
|
| 2012 |
Haass C, Kaether C, Thinakaran G, Sisodia S. Trafficking and proteolytic processing of APP. Cold Spring Harbor Perspectives in Medicine. 2: a006270. PMID 22553493 DOI: 10.1101/Cshperspect.A006270 |
0.458 |
|
| 2012 |
Lang CM, Fellerer K, Schwenk BM, Kuhn PH, Kremmer E, Edbauer D, Capell A, Haass C. Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. The Journal of Biological Chemistry. 287: 19355-65. PMID 22511793 DOI: 10.1074/Jbc.M112.365098 |
0.633 |
|
| 2012 |
Grundmann K, Glöckle N, Martella G, Sciamanna G, Hauser TK, Yu L, Castaneda S, Pichler B, Fehrenbacher B, Schaller M, Nuscher B, Haass C, Hettich J, Yue Z, Nguyen HP, et al. Generation of a novel rodent model for DYT1 dystonia. Neurobiology of Disease. 47: 61-74. PMID 22472189 DOI: 10.1016/J.Nbd.2012.03.024 |
0.324 |
|
| 2012 |
Fleck D, Garratt AN, Haass C, Willem M. BACE1 dependent neuregulin processing: review. Current Alzheimer Research. 9: 178-83. PMID 22455478 DOI: 10.2174/156720512799361637 |
0.378 |
|
| 2012 |
Leuner K, Schütt T, Kurz C, Eckert SH, Schiller C, Occhipinti A, Mai S, Jendrach M, Eckert GP, Kruse SE, Palmiter RD, Brandt U, Dröse S, Wittig I, Willem M, ... Haass C, et al. Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxidants & Redox Signaling. 16: 1421-33. PMID 22229260 DOI: 10.1089/Ars.2011.4173 |
0.369 |
|
| 2012 |
Fluhrer R, Martin L, Klier B, Haug-Kröper M, Grammer G, Nuscher B, Haass C. The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b). The Journal of Biological Chemistry. 287: 5156-63. PMID 22194595 DOI: 10.1074/Jbc.M111.328104 |
0.314 |
|
| 2012 |
Rominger A, Brendel M, Baumann K, Gildehaus F, Niedermoser S, Wängler B, Burgold S, Herms J, Cumming P, Steiner H, Haass C, Bartenstein P. Longitudinal imaging of cerebral beta-amyloid in APP-swe mice using [18F]florbetaben PET Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.411 |
0.566 |
|
| 2012 |
Lichtenthaler S, Dislich B, Hogl S, Colombo A, Zeitschel U, Willem M, Haass C, Volbracht C, Roßner S, Kuhn P. Therapeutic potential of BACE1/beta-secretase: Proteome-wide identification of physiological BACE1 substrates in primary neurons and mouse brain Alzheimers & Dementia. 8: 96. DOI: 10.1016/J.Jalz.2012.05.236 |
0.354 |
|
| 2012 |
Rominger A, Brendel M, Baumann K, Gildehaus F, Niedermoser S, Wängler B, Burgold S, Herms J, Cumming P, Steiner H, Haass C, Bartenstein P. Longitudinal imaging of cerebral Aβ in APP-Swe mice using [18F]florbetaben PET Alzheimers & Dementia. 8: 11. DOI: 10.1016/J.Jalz.2012.05.033 |
0.532 |
|
| 2011 |
Lammich S, Kamp F, Wagner J, Nuscher B, Zilow S, Ludwig AK, Willem M, Haass C. Translational repression of the disintegrin and metalloprotease ADAM10 by a stable G-quadruplex secondary structure in its 5'-untranslated region. The Journal of Biological Chemistry. 286: 45063-72. PMID 22065584 DOI: 10.1074/Jbc.M111.296921 |
0.34 |
|
| 2011 |
Ebke A, Luebbers T, Fukumori A, Shirotani K, Haass C, Baumann K, Steiner H. Novel γ-secretase enzyme modulators directly target presenilin protein. The Journal of Biological Chemistry. 286: 37181-6. PMID 21896486 DOI: 10.1074/Jbc.C111.276972 |
0.424 |
|
| 2011 |
Neumann M, Bentmann E, Dormann D, Jawaid A, DeJesus-Hernandez M, Ansorge O, Roeber S, Kretzschmar HA, Munoz DG, Kusaka H, Yokota O, Ang LC, Bilbao J, Rademakers R, Haass C, et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain : a Journal of Neurology. 134: 2595-609. PMID 21856723 DOI: 10.1093/Brain/Awr201 |
0.369 |
|
| 2011 |
Fluhrer R, Kamp F, Grammer G, Nuscher B, Steiner H, Beyer K, Haass C. The Nicastrin ectodomain adopts a highly thermostable structure. Biological Chemistry. 392: 995-1001. PMID 21848507 DOI: 10.1515/Bc.2011.169 |
0.398 |
|
| 2011 |
Dormann D, Haass C. TDP-43 and FUS: a nuclear affair. Trends in Neurosciences. 34: 339-48. PMID 21700347 DOI: 10.1016/J.Tins.2011.05.002 |
0.337 |
|
| 2011 |
Fleck D, Garratt AN, Haass C, Willem M. BACE1 Dependent Neuregulin Proteolysis. Current Alzheimer Research. PMID 21605034 |
0.309 |
|
| 2011 |
Lichtenthaler SF, Haass C, Steiner H. Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing. Journal of Neurochemistry. 117: 779-96. PMID 21413990 DOI: 10.1111/J.1471-4159.2011.07248.X |
0.428 |
|
| 2011 |
Kretner B, Fukumori A, Gutsmiedl A, Page RM, Luebbers T, Galley G, Baumann K, Haass C, Steiner H. Attenuated Abeta42 responses to low potency gamma-secretase modulators can be overcome for many pathogenic presenilin mutants by second-generation compounds. The Journal of Biological Chemistry. 286: 15240-51. PMID 21357415 DOI: 10.1074/Jbc.M110.213587 |
0.341 |
|
| 2011 |
Capell A, Liebscher S, Fellerer K, Brouwers N, Willem M, Lammich S, Gijselinck I, Bittner T, Carlson AM, Sasse F, Kunze B, Steinmetz H, Jansen R, Dormann D, Sleegers K, ... ... Haass C, et al. Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1885-94. PMID 21289198 DOI: 10.1523/Jneurosci.5757-10.2011 |
0.335 |
|
| 2011 |
Rolyan H, Feike AC, Upadhaya AR, Waha A, Van Dooren T, Haass C, Birkenmeier G, Pietrzik CU, Van Leuven F, Thal DR. Amyloid-β protein modulates the perivascular clearance of neuronal apolipoprotein E in mouse models of Alzheimer's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 699-712. PMID 21210284 DOI: 10.1007/S00702-010-0572-7 |
0.397 |
|
| 2011 |
Upadhaya AR, Capetillo-Zarate E, Lungrin I, Abramowski D, Kumar S, Yamaguchi H, Haass C, Walter J, Staufenbiel M, Fändrich M, Thal D. P3-165: Elevated levels of soluble, high molecular weight SDS-denaturable Aβ-aggregates are associated with dendritic degeneration in APP-transgenic mouse models Alzheimer's & Dementia. 7: S569-S570. DOI: 10.1016/J.Jalz.2011.05.1605 |
0.352 |
|
| 2010 |
Förstl H, Haass C, Hemmer B, Meyer B, Halle M. Boxing-acute complications and late sequelae: from concussion to dementia. Deutsches ã„Rzteblatt International. 107: 835-9. PMID 21173899 DOI: 10.3238/Arztebl.2010.0835 |
0.392 |
|
| 2010 |
Bartels T, Ahlstrom LS, Leftin A, Kamp F, Haass C, Brown MF, Beyer K. The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophysical Journal. 99: 2116-24. PMID 20923645 DOI: 10.1016/J.Bpj.2010.06.035 |
0.725 |
|
| 2010 |
Kamp F, Exner N, Lutz AK, Wender N, Hegermann J, Brunner B, Nuscher B, Bartels T, Giese A, Beyer K, Eimer S, Winklhofer KF, Haass C. Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. The Embo Journal. 29: 3571-89. PMID 20842103 DOI: 10.1038/Emboj.2010.223 |
0.713 |
|
| 2010 |
Haass C, Mandelkow E. Fyn-tau-amyloid: a toxic triad. Cell. 142: 356-8. PMID 20691893 DOI: 10.1016/J.Cell.2010.07.032 |
0.442 |
|
| 2010 |
Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF. Parkin is protective against proteotoxic stress in a transgenic zebrafish model. Plos One. 5: e11783. PMID 20689587 DOI: 10.1371/Journal.Pone.0011783 |
0.31 |
|
| 2010 |
Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than ME, Mackenzie IR, Capell A, Schmid B, Neumann M, Haass C. ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. The Embo Journal. 29: 2841-57. PMID 20606625 DOI: 10.1038/Emboj.2010.143 |
0.621 |
|
| 2010 |
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, et al. Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8974-83. PMID 20592218 DOI: 10.1523/Jneurosci.1199-10.2010 |
0.406 |
|
| 2010 |
Dettmer U, Kuhn PH, Abou-Ajram C, Lichtenthaler SF, Krüger M, Kremmer E, Haass C, Haffner C. Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex. The Journal of Biological Chemistry. 285: 26174-81. PMID 20538592 DOI: 10.1074/Jbc.M110.132548 |
0.784 |
|
| 2010 |
Fukumori A, Fluhrer R, Steiner H, Haass C. Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7853-62. PMID 20534834 DOI: 10.1523/Jneurosci.1443-10.2010 |
0.45 |
|
| 2010 |
van Bebber F, Paquet D, Hruscha A, Schmid B, Haass C. Methylene blue fails to inhibit Tau and polyglutamine protein dependent toxicity in zebrafish. Neurobiology of Disease. 39: 265-71. PMID 20381619 DOI: 10.1016/J.Nbd.2010.03.023 |
0.442 |
|
| 2010 |
Page RM, Gutsmiedl A, Fukumori A, Winkler E, Haass C, Steiner H. Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. The Journal of Biological Chemistry. 285: 17798-810. PMID 20348104 DOI: 10.1074/Jbc.M110.103283 |
0.446 |
|
| 2010 |
Lammich S, Buell D, Zilow S, Ludwig AK, Nuscher B, Lichtenthaler SF, Prinzen C, Fahrenholz F, Haass C. Expression of the anti-amyloidogenic secretase ADAM10 is suppressed by its 5'-untranslated region. The Journal of Biological Chemistry. 285: 15753-60. PMID 20348102 DOI: 10.1074/Jbc.M110.110742 |
0.449 |
|
| 2010 |
Fuhrmann M, Bittner T, Jung CK, Burgold S, Page RM, Mitteregger G, Haass C, LaFerla FM, Kretzschmar H, Herms J. Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nature Neuroscience. 13: 411-3. PMID 20305648 DOI: 10.1038/Nn.2511 |
0.36 |
|
| 2010 |
Paquet D, Schmid B, Haass C. Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo. Neuro-Degenerative Diseases. 7: 99-102. PMID 20173336 DOI: 10.1159/000285515 |
0.36 |
|
| 2010 |
Pérez-Revuelta BI, Fukumori A, Lammich S, Yamasaki A, Haass C, Steiner H. Requirement for small side chain residues within the GxGD-motif of presenilin for gamma-secretase substrate cleavage. Journal of Neurochemistry. 112: 940-50. PMID 20021564 DOI: 10.1111/J.1471-4159.2009.06510.X |
0.387 |
|
| 2010 |
Fassler M, Zocher M, Klare S, de la Fuente AG, Scheuermann J, Capell A, Haass C, Valkova C, Veerappan A, Schneider D, Kaether C. Masking of transmembrane-based retention signals controls ER export of gamma-secretase. Traffic (Copenhagen, Denmark). 11: 250-8. PMID 19958468 DOI: 10.1111/J.1600-0854.2009.01014.X |
0.327 |
|
| 2010 |
Haass C, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than M, Mackenzie I, Capell A, Schmid B, Neumann M, Dormann D. O4-03-06: Familial Als-associated Fused in Sarcoma (fus) Mutations Disrupt Transportin-mediated Nuclear Import Alzheimer's & Dementia. 6: e17-e17. DOI: 10.1016/J.Jalz.2010.08.051 |
0.576 |
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| 2010 |
Haass C, Fukumori A, Steiner H. O2-03-02: Stepwise autoproteolysis of presenilin 1 is affected by familial Alzheimer's disease mutations Alzheimer's & Dementia. 6: S101-S101. DOI: 10.1016/J.Jalz.2010.05.315 |
0.325 |
|
| 2009 |
Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S, Arai T, Ikeuchi T, Kasuga K, Tokuda T, Kondo M, Ikeda M, ... ... Haass C, et al. The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. Embo Molecular Medicine. 1: 223-35. PMID 20049724 DOI: 10.1002/Emmm.200900026 |
0.449 |
|
| 2009 |
Itoh N, Okochi M, Tagami S, Nishitomi K, Nakayama T, Yanagida K, Fukumori A, Jiang J, Mori K, Hosono M, Kikuchi J, Nakano Y, Takinami Y, Dohi K, Nishigaki A, ... ... Haass C, et al. Destruxin E decreases Beta-amyloid generation by reducing colocalization of beta-amyloid-cleaving enzyme 1 and beta-amyloid protein precursor. Neuro-Degenerative Diseases. 6: 230-9. PMID 19738368 DOI: 10.1159/000236902 |
0.436 |
|
| 2009 |
Bittner T, Fuhrmann M, Burgold S, Jung CK, Volbracht C, Steiner H, Mitteregger G, Kretzschmar HA, Haass C, Herms J. Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10405-9. PMID 19692615 DOI: 10.1523/Jneurosci.2288-09.2009 |
0.434 |
|
| 2009 |
Fournier M, Vitte J, Garrigue J, Langui D, Dullin JP, Saurini F, Hanoun N, Perez-Diaz F, Cornilleau F, Joubert C, Ardila-Osorio H, Traver S, Duchateau R, Goujet-Zalc C, Paleologou K, ... ... Haass C, et al. Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. Plos One. 4: e6629. PMID 19680561 DOI: 10.1371/Journal.Pone.0006629 |
0.312 |
|
| 2009 |
Dormann D, Capell A, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. Journal of Neurochemistry. 110: 1082-94. PMID 19522733 DOI: 10.1111/J.1471-4159.2009.06211.X |
0.387 |
|
| 2009 |
Willem M, Lammich S, Haass C. Function, regulation and therapeutic properties of beta-secretase (BACE1). Seminars in Cell & Developmental Biology. 20: 175-82. PMID 19429494 DOI: 10.1016/J.Semcdb.2009.01.003 |
0.47 |
|
| 2009 |
Paquet D, Bhat R, Sydow A, Mandelkow EM, Berg S, Hellberg S, Fälting J, Distel M, Köster RW, Schmid B, Haass C. A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. The Journal of Clinical Investigation. 119: 1382-95. PMID 19363289 DOI: 10.1172/Jci37537 |
0.369 |
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| 2009 |
Fluhrer R, Steiner H, Haass C. Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. The Journal of Biological Chemistry. 284: 13975-9. PMID 19189970 DOI: 10.1074/Jbc.R800040200 |
0.326 |
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| 2009 |
Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H. Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry. 48: 1183-97. PMID 19159235 DOI: 10.1021/Bi801204G |
0.448 |
|
| 2009 |
Martin L, Fluhrer R, Haass C. Substrate requirements for SPPL2b-dependent regulated intramembrane proteolysis. The Journal of Biological Chemistry. 284: 5662-70. PMID 19114711 DOI: 10.1074/Jbc.M807485200 |
0.329 |
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| 2009 |
Jawaid A, Rademakers R, Kass JS, Kalkonde Y, Okochi M, Tagami S, Nishitomi K, Nef T, Quinter G, Isobe C, Abe T, Portelius E, Zhang B, Benetin J, Zerr I, ... ... Haass C, et al. Contents Vol. 6, 2009 Neurodegenerative Diseases. 6. DOI: 10.1159/000278750 |
0.309 |
|
| 2009 |
Jawaid A, Rademakers R, Kass JS, Kalkonde Y, Okochi M, Tagami S, Nishitomi K, Nef T, Quinter G, Isobe C, Abe T, Portelius E, Zhang B, Benetin J, Zerr I, ... ... Haass C, et al. Subject Index Vol. 6, 2009 Neurodegenerative Diseases. 6: 282-282. DOI: 10.1159/000278749 |
0.315 |
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| 2009 |
Haass C. Alzheimer - Mechanismen und therapeutische Ansätze. Warum wir im Alter dement werden Biologie in Unserer Zeit. 39: 92-100. DOI: 10.1002/Biuz.200910388 |
0.359 |
|
| 2008 |
O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047 |
0.436 |
|
| 2008 |
Busche MA, Eichhoff G, Adelsberger H, Abramowski D, Wiederhold KH, Haass C, Staufenbiel M, Konnerth A, Garaschuk O. Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science (New York, N.Y.). 321: 1686-9. PMID 18802001 DOI: 10.1126/Science.1162844 |
0.367 |
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| 2008 |
Steiner H, Winkler E, Haass C. Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1. The Journal of Biological Chemistry. 283: 34677-86. PMID 18801744 DOI: 10.1074/Jbc.M709067200 |
0.388 |
|
| 2008 |
Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C. Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation. The Journal of Biological Chemistry. 283: 30121-8. PMID 18768471 DOI: 10.1074/Jbc.M806092200 |
0.426 |
|
| 2008 |
Steiner H, Fluhrer R, Haass C. Intramembrane proteolysis by gamma-secretase. The Journal of Biological Chemistry. 283: 29627-31. PMID 18650432 DOI: 10.1074/Jbc.R800010200 |
0.439 |
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| 2008 |
Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. 105: 9775-80. PMID 18626010 DOI: 10.1073/Pnas.0800507105 |
0.333 |
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| 2008 |
St George-Hyslop P, Haass C. Regulatory RNA goes awry in Alzheimer's disease. Nature Medicine. 14: 711-2. PMID 18607365 DOI: 10.1038/Nm0708-711 |
0.332 |
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| 2008 |
Schöbel S, Neumann S, Hertweck M, Dislich B, Kuhn PH, Kremmer E, Seed B, Baumeister R, Haass C, Lichtenthaler SF. A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. The Journal of Biological Chemistry. 283: 14257-68. PMID 18353773 DOI: 10.1074/Jbc.M801531200 |
0.417 |
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| 2008 |
Winklhofer KF, Tatzelt J, Haass C. The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. The Embo Journal. 27: 336-49. PMID 18216876 DOI: 10.1038/Sj.Emboj.7601930 |
0.397 |
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| 2008 |
Shankaran SS, Capell A, Hruscha AT, Fellerer K, Neumann M, Schmid B, Haass C. Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. The Journal of Biological Chemistry. 283: 1744-53. PMID 17984093 DOI: 10.1074/Jbc.M705115200 |
0.358 |
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| 2008 |
Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C. Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. The Journal of Biological Chemistry. 283: 1644-52. PMID 17965014 DOI: 10.1074/Jbc.M706661200 |
0.349 |
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| 2008 |
Page RM, Baumann K, Tomioka M, Pérez-Revuelta BI, Fukumori A, Jacobsen H, Flohr A, Luebbers T, Ozmen L, Steiner H, Haass C. Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. The Journal of Biological Chemistry. 283: 677-83. PMID 17962197 DOI: 10.1074/Jbc.M708754200 |
0.438 |
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| 2008 |
Haass C. S4-01-06: Mechanisms of intramembrane proteolysis by gamma-secretase and related proteases Alzheimer's & Dementia. 4: T178-T178. DOI: 10.1016/J.Jalz.2008.05.477 |
0.4 |
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| 2008 |
Lichtenthaler SF, Mitterreiter S, Haass C. O1-04-01: Novel drugs simultaneously modulate both beta- and gamma-secretase cleavage of the amyloid precursor protein Alzheimer's & Dementia. 4: T114-T114. DOI: 10.1016/J.Jalz.2008.05.238 |
0.37 |
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| 2008 |
Fluhrer R, Fukumori A, Martin L, Teplow DB, Steiner H, Haass C. P4-188: Intramembrane cleavage of TNFalpha by SPPL2b carrying a familial Alzheimer's disease-like mutation Alzheimer's & Dementia. 4: T726-T726. DOI: 10.1016/J.Jalz.2008.05.2255 |
0.347 |
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| 2008 |
Lammich S, Zilow S, Büll D, Ludwig A, Prinzen C, Fahrenholz F, Jacquemin-Sablon H, Haass C. P3-335: Upstream of N-ras (UNR) is involved in translational control of ADAM10 protein expression Alzheimer's & Dementia. 4: T620-T620. DOI: 10.1016/J.Jalz.2008.05.1904 |
0.374 |
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| 2007 |
Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/Jbc.M705248200 |
0.412 |
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| 2007 |
Hamid R, Kilger E, Willem M, Vassallo N, Kostka M, Bornhövd C, Reichert AS, Kretzschmar HA, Haass C, Herms J. Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content. Journal of Neurochemistry. 102: 1264-75. PMID 17763532 DOI: 10.1111/J.1471-4159.2007.04627.X |
0.305 |
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| 2007 |
Kaether C, Scheuermann J, Fassler M, Zilow S, Shirotani K, Valkova C, Novak B, Kacmar S, Steiner H, Haass C. Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1. Embo Reports. 8: 743-8. PMID 17668005 DOI: 10.1038/Sj.Embor.7401027 |
0.433 |
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| 2007 |
Fluhrer R, Haass C. Signal peptide peptidases and gamma-secretase: cousins of the same protease family? Neuro-Degenerative Diseases. 4: 112-6. PMID 17596705 DOI: 10.1159/000101835 |
0.363 |
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| 2007 |
Shirotani K, Tomioka M, Kremmer E, Haass C, Steiner H. Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiology of Disease. 27: 102-7. PMID 17560791 DOI: 10.1016/J.Nbd.2007.04.011 |
0.467 |
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| 2007 |
Prager K, Wang-Eckhardt L, Fluhrer R, Killick R, Barth E, Hampel H, Haass C, Walter J. A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling. The Journal of Biological Chemistry. 282: 14083-93. PMID 17360711 DOI: 10.1074/Jbc.M608437200 |
0.383 |
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| 2007 |
Görner K, Holtorf E, Waak J, Pham TT, Vogt-Weisenhorn DM, Wurst W, Haass C, Kahle PJ. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. The Journal of Biological Chemistry. 282: 13680-91. PMID 17331951 DOI: 10.1074/Jbc.M609821200 |
0.329 |
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| 2007 |
Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. The Journal of Biological Chemistry. 282: 11982-95. PMID 17307738 DOI: 10.1074/Jbc.M700356200 |
0.305 |
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| 2007 |
Haffner C, Dettmer U, Weiler T, Haass C. The Nicastrin-like protein Nicalin regulates assembly and stability of the Nicalin-nodal modulator (NOMO) membrane protein complex. The Journal of Biological Chemistry. 282: 10632-8. PMID 17261586 DOI: 10.1074/Jbc.M611033200 |
0.791 |
|
| 2007 |
Haass C, Selkoe DJ. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nature Reviews. Molecular Cell Biology. 8: 101-12. PMID 17245412 DOI: 10.1038/Nrm2101 |
0.674 |
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| 2007 |
Schiffer NW, Broadley SA, Hirschberger T, Tavan P, Kretzschmar HA, Giese A, Haass C, Hartl FU, Schmid B. Identification of anti-prion compounds as efficient inhibitors of polyglutamine protein aggregation in a zebrafish model. The Journal of Biological Chemistry. 282: 9195-203. PMID 17170113 DOI: 10.1074/Jbc.M607865200 |
0.369 |
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| 2007 |
Narlawar R, Pérez Revuelta BI, Baumann K, Schubenel R, Haass C, Steiner H, Schmidt B. N-Substituted carbazolyloxyacetic acids modulate Alzheimer associated gamma-secretase. Bioorganic & Medicinal Chemistry Letters. 17: 176-82. PMID 17035010 DOI: 10.1016/J.Bmcl.2006.09.061 |
0.37 |
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| 2007 |
Thal DR, Larionov S, Abramowski D, Wiederhold KH, Van Dooren T, Yamaguchi H, Haass C, Van Leuven F, Staufenbiel M, Capetillo-Zarate E. Occurrence and co-localization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice. Neurobiology of Aging. 28: 1221-30. PMID 16815595 DOI: 10.1016/J.Neurobiolaging.2006.05.029 |
0.409 |
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| 2006 |
Narlawar R, Pérez Revuelta BI, Haass C, Steiner H, Schmidt B, Baumann K. Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators. Journal of Medicinal Chemistry. 49: 7588-91. PMID 17181139 DOI: 10.1021/Jm0610200 |
0.36 |
|
| 2006 |
Haffner C, Haass C. Cellular functions of gamma-secretase-related proteins. Neuro-Degenerative Diseases. 3: 284-9. PMID 17047369 DOI: 10.1159/000095268 |
0.409 |
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| 2006 |
Kaether C, Haass C, Steiner H. Assembly, trafficking and function of gamma-secretase. Neuro-Degenerative Diseases. 3: 275-83. PMID 17047368 DOI: 10.1159/000095267 |
0.434 |
|
| 2006 |
Willem M, Garratt AN, Novak B, Citron M, Kaufmann S, Rittger A, DeStrooper B, Saftig P, Birchmeier C, Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science (New York, N.Y.). 314: 664-6. PMID 16990514 DOI: 10.1126/Science.1132341 |
0.338 |
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| 2006 |
Radde R, Bolmont T, Kaeser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, et al. Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. Embo Reports. 7: 940-6. PMID 16906128 DOI: 10.1038/Sj.Embor.7400784 |
0.425 |
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| 2006 |
Steiner H, Than M, Bode W, Haass C. Pore-forming scissors? A first structural glimpse of gamma-secretase. Trends in Biochemical Sciences. 31: 491-3. PMID 16890442 DOI: 10.1016/J.Tibs.2006.07.008 |
0.468 |
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| 2006 |
Capetillo-Zarate E, Staufenbiel M, Abramowski D, Haass C, Escher A, Stadelmann C, Yamaguchi H, Wiestler OD, Thal DR. Selective vulnerability of different types of commissural neurons for amyloid beta-protein-induced neurodegeneration in APP23 mice correlates with dendritic tree morphology. Brain : a Journal of Neurology. 129: 2992-3005. PMID 16844716 DOI: 10.1093/Brain/Awl176 |
0.389 |
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| 2006 |
Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C. A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nature Cell Biology. 8: 894-6. PMID 16829951 DOI: 10.1038/Ncb1450 |
0.334 |
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| 2006 |
Goldsbury C, Mocanu MM, Thies E, Kaether C, Haass C, Keller P, Biernat J, Mandelkow E, Mandelkow EM. Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (Copenhagen, Denmark). 7: 873-88. PMID 16734669 DOI: 10.1111/J.1600-0854.2006.00434.X |
0.42 |
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| 2006 |
Anders L, Mertins P, Lammich S, Murgia M, Hartmann D, Saftig P, Haass C, Ullrich A. Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Molecular and Cellular Biology. 26: 3917-34. PMID 16648485 DOI: 10.1128/Mcb.26.10.3917-3934.2006 |
0.379 |
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| 2006 |
Fukumori A, Okochi M, Tagami S, Jiang J, Itoh N, Nakayama T, Yanagida K, Ishizuka-Katsura Y, Morihara T, Kamino K, Tanaka T, Kudo T, Tanii H, Ikuta A, Haass C, et al. Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. Biochemistry. 45: 4907-14. PMID 16605258 DOI: 10.1021/Bi052412W |
0.4 |
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| 2006 |
Yamasaki A, Eimer S, Okochi M, Smialowska A, Kaether C, Baumeister R, Haass C, Steiner H. The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3821-8. PMID 16597736 DOI: 10.1523/Jneurosci.5354-05.2006 |
0.386 |
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| 2006 |
Kaether C, Schmitt S, Willem M, Haass C. Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic (Copenhagen, Denmark). 7: 408-15. PMID 16536739 DOI: 10.1111/J.1600-0854.2006.00396.X |
0.433 |
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| 2006 |
Böhm C, Seibel NM, Henkel B, Steiner H, Haass C, Hampe W. SorLA signaling by regulated intramembrane proteolysis. The Journal of Biological Chemistry. 281: 14547-53. PMID 16531402 DOI: 10.1074/Jbc.M601660200 |
0.335 |
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| 2006 |
Okochi M, Fukumori A, Jiang J, Itoh N, Kimura R, Steiner H, Haass C, Tagami S, Takeda M. Secretion of the Notch-1 Abeta-like peptide during Notch signaling. The Journal of Biological Chemistry. 281: 7890-8. PMID 16434391 DOI: 10.1074/Jbc.M513250200 |
0.409 |
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| 2006 |
Neumann S, Schöbel S, Jäger S, Trautwein A, Haass C, Pietrzik CU, Lichtenthaler SF. Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor protein. The Journal of Biological Chemistry. 281: 7583-94. PMID 16344553 DOI: 10.1074/Jbc.M508340200 |
0.477 |
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| 2006 |
Haass C, Multhaup G. Six years of collaborative Alzheimer's disease research in Germany Neurodegenerative Diseases. 3: 193-196. DOI: 10.1159/000095256 |
0.331 |
|
| 2006 |
Capell A, Wild-Bode C, Haass C. P2-045: A novel basolateral sorting signal directs α-secretase (ADAM10) to adherens junctions and limits amyloid generation Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.882 |
0.311 |
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| 2006 |
Thal DR, Larionov S, Abramowski D, Wiederhold K, Yamaguchi H, Haass C, Staufenbiel M, Capetillo-Zarate E. P1-029: Occurrence of amyloid β-protein and co-localization with apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice Alzheimer's & Dementia. 2: S102-S103. DOI: 10.1016/J.Jalz.2006.05.404 |
0.336 |
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| 2006 |
Neumann S, Schöbel S, Jäger S, Haass C, Pietrzik CU, Lichtenthaler SF. P4-070: Amyloid precursor-like proteins 1 and 2 influence proteolytic processing of the amyloid precursor protein by alpha- and beta-secretase Alzheimer's & Dementia. 2: S534-S534. DOI: 10.1016/J.Jalz.2006.05.1808 |
0.416 |
|
| 2006 |
Schöbel S, Neumann S, Haass C, Lichtenthaler SF. P4-058: Sorting nexin 31 is a novel activator of the alpha-cleavage of the amyloid precursor protein Alzheimer's & Dementia. 2: S530-S530. DOI: 10.1016/J.Jalz.2006.05.1796 |
0.343 |
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| 2006 |
Fischer SV, Haass C, Lichtenthaler SF. P4-003: A novel protein interacts with APP and modifies APP secretion Alzheimer's & Dementia. 2: S514-S514. DOI: 10.1016/J.Jalz.2006.05.1741 |
0.334 |
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| 2006 |
Ikuta A, Tagami S, Jiang J, Yanagida K, Nakayama T, Ishizuka-Katsura Y, Mori K, Tao H, Morihara T, Kamino K, Tanaka T, Kudo T, Steiner H, Haass C, Okochi M, et al. P3-253: Aβ generation and degradation by BACE1 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1522 |
0.334 |
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| 2006 |
Lichtenthaler SF, Schöbel S, Neumann S, Fischer S, Haass C. O2-03-01: Novel proteins act as gatekeepers and control access of APP to alpha- and beta-secretase Alzheimer's & Dementia. 2: S34-S35. DOI: 10.1016/J.Jalz.2006.05.120 |
0.324 |
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| 2005 |
Thal DR, Capetillo-Zarate E, Schultz C, Rüb U, Saido TC, Yamaguchi H, Haass C, Griffin WS, Del Tredici K, Braak H, Ghebremedhin E. Apolipoprotein E co-localizes with newly formed amyloid beta-protein (Abeta) deposits lacking immunoreactivity against N-terminal epitopes of Abeta in a genotype-dependent manner. Acta Neuropathologica. 110: 459-71. PMID 16195918 DOI: 10.1007/S00401-005-1053-1 |
0.44 |
|
| 2005 |
Krawitz P, Haffner C, Fluhrer R, Steiner H, Schmid B, Haass C. Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. The Journal of Biological Chemistry. 280: 39515-23. PMID 15998642 DOI: 10.1074/Jbc.M501645200 |
0.369 |
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| 2005 |
Giese A, Bader B, Bieschke J, Schaffar G, Odoy S, Kahle PJ, Haass C, Kretzschmar H. Single particle detection and characterization of synuclein co-aggregation. Biochemical and Biophysical Research Communications. 333: 1202-10. PMID 15978545 DOI: 10.1016/J.Bbrc.2005.06.025 |
0.367 |
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| 2005 |
Prokop S, Haass C, Steiner H. Length and overall sequence of the PEN-2 C-terminal domain determines its function in the stabilization of presenilin fragments. Journal of Neurochemistry. 94: 57-62. PMID 15953349 DOI: 10.1111/J.1471-4159.2005.03165.X |
0.656 |
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| 2005 |
Wahle T, Prager K, Raffler N, Haass C, Famulok M, Walter J. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Molecular and Cellular Neurosciences. 29: 453-61. PMID 15886016 DOI: 10.1016/J.Mcn.2005.03.014 |
0.345 |
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| 2005 |
Uelhoff A, Tatzelt J, Aguzzi A, Winklhofer KF, Haass C. A pathogenic PrP mutation and doppel interfere with polarized sorting of the prion protein. The Journal of Biological Chemistry. 280: 5137-40. PMID 15615717 DOI: 10.1074/Jbc.C400560200 |
0.562 |
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| 2005 |
Capell A, Beher D, Prokop S, Steiner H, Kaether C, Shearman MS, Haass C. Gamma-secretase complex assembly within the early secretory pathway. The Journal of Biological Chemistry. 280: 6471-8. PMID 15591316 DOI: 10.1074/jbc.M409106200 |
0.649 |
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| 2005 |
Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C. Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. The Journal of Biological Chemistry. 280: 3390-9. PMID 15557340 DOI: 10.1074/Jbc.M407724200 |
0.318 |
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| 2004 |
Haffner C, Haass C. The biochemical and genetic odyssey to the function of a nicastrin-like protein. Neuro-Degenerative Diseases. 1: 192-5. PMID 16908989 DOI: 10.1159/000080985 |
0.375 |
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| 2004 |
Kaether C, Haass C. A lipid boundary separates APP and secretases and limits amyloid beta-peptide generation. The Journal of Cell Biology. 167: 809-12. PMID 15583026 DOI: 10.1083/Jcb.200410090 |
0.393 |
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| 2004 |
Kaether C, Capell A, Edbauer D, Winkler E, Novak B, Steiner H, Haass C. The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. The Embo Journal. 23: 4738-48. PMID 15549135 DOI: 10.1038/Sj.Emboj.7600478 |
0.644 |
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| 2004 |
Willem M, Dewachter I, Smyth N, Van Dooren T, Borghgraef P, Haass C, Van Leuven F. beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice. The American Journal of Pathology. 165: 1621-31. PMID 15509532 DOI: 10.1016/S0002-9440(10)63419-0 |
0.446 |
|
| 2004 |
Westmeyer GG, Willem M, Lichtenthaler SF, Lurman G, Multhaup G, Assfalg-Machleidt I, Reiss K, Saftig P, Haass C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. The Journal of Biological Chemistry. 279: 53205-12. PMID 15485862 DOI: 10.1074/Jbc.M410378200 |
0.758 |
|
| 2004 |
Keil U, Bonert A, Marques CA, Scherping I, Weyermann J, Strosznajder JB, Müller-Spahn F, Haass C, Czech C, Pradier L, Müller WE, Eckert A. Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. The Journal of Biological Chemistry. 279: 50310-20. PMID 15371443 DOI: 10.1074/Jbc.M405600200 |
0.425 |
|
| 2004 |
Shirotani K, Edbauer D, Prokop S, Haass C, Steiner H. Identification of distinct gamma-secretase complexes with different APH-1 variants. The Journal of Biological Chemistry. 279: 41340-5. PMID 15286082 DOI: 10.1074/Jbc.M405768200 |
0.746 |
|
| 2004 |
Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. The Embo Journal. 23: 3041-50. PMID 15257293 DOI: 10.1038/Sj.Emboj.7600307 |
0.325 |
|
| 2004 |
Schmechel A, Strauss M, Schlicksupp A, Pipkorn R, Haass C, Bayer TA, Multhaup G. Human BACE forms dimers and colocalizes with APP. The Journal of Biological Chemistry. 279: 39710-7. PMID 15247262 DOI: 10.1074/Jbc.M402785200 |
0.409 |
|
| 2004 |
Kahle PJ, Haass C. How does parkin ligate ubiquitin to Parkinson's disease? Embo Reports. 5: 681-5. PMID 15229644 DOI: 10.1038/Sj.Embor.7400188 |
0.369 |
|
| 2004 |
Edbauer D, Kaether C, Steiner H, Haass C. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. The Journal of Biological Chemistry. 279: 37311-5. PMID 15210705 DOI: 10.1074/Jbc.M406228200 |
0.658 |
|
| 2004 |
Shirotani K, Edbauer D, Kostka M, Steiner H, Haass C. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1. Journal of Neurochemistry. 89: 1520-7. PMID 15189355 DOI: 10.1111/J.1471-4159.2004.02447.X |
0.696 |
|
| 2004 |
Lammich S, Schöbel S, Zimmer AK, Lichtenthaler SF, Haass C. Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. Embo Reports. 5: 620-5. PMID 15167888 DOI: 10.1038/Sj.Embor.7400166 |
0.364 |
|
| 2004 |
Lichtenthaler SF, Haass C. Amyloid at the cutting edge: activation of alpha-secretase prevents amyloidogenesis in an Alzheimer disease mouse model. The Journal of Clinical Investigation. 113: 1384-7. PMID 15146234 DOI: 10.1172/Jci21746 |
0.389 |
|
| 2004 |
Prokop S, Shirotani K, Edbauer D, Haass C, Steiner H. Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. The Journal of Biological Chemistry. 279: 23255-61. PMID 15039426 DOI: 10.1074/Jbc.M401789200 |
0.766 |
|
| 2004 |
Neumann M, Müller V, Görner K, Kretzschmar HA, Haass C, Kahle PJ. Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathologica. 107: 489-96. PMID 14991385 DOI: 10.1007/S00401-004-0834-2 |
0.347 |
|
| 2004 |
Haass C. Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation. The Embo Journal. 23: 483-8. PMID 14749724 DOI: 10.1038/Sj.Emboj.7600061 |
0.398 |
|
| 2004 |
Görner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ. Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. The Journal of Biological Chemistry. 279: 6943-51. PMID 14607841 DOI: 10.1074/Jbc.M309204200 |
0.328 |
|
| 2004 |
Fluhrer R, Friedlein A, Haass C, Walter J. Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis. The Journal of Biological Chemistry. 279: 1585-93. PMID 14576165 DOI: 10.1074/Jbc.M306653200 |
0.325 |
|
| 2004 |
Eckert A, Keil U, Bonert A, Scherping I, Marques CA, Haass C, Czech C, Pradier L, Müller WE. P4-252 Impact of β-amyloid on mitochondrial failure in Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81810-4 |
0.357 |
|
| 2004 |
Lichtenthaler SF, Schöbel S, Neumann S, Seed B, Haass C. P4-198 Genome-wide screen identifies proteins stimulating the alpha- and beta-secretase cleavage of AFP Neurobiology of Aging. 25: S531. DOI: 10.1016/S0197-4580(04)81756-1 |
0.301 |
|
| 2004 |
Steiner H, Prokop S, Shirotani K, Edbauer D, Winkler E, Haass C. P4-192 Structure-function analysis of the gamma-secretase complex subunit PEN-2 Neurobiology of Aging. 25: S530. DOI: 10.1016/S0197-4580(04)81750-0 |
0.72 |
|
| 2004 |
Hamid R, Willem M, Edbauer D, Steiner H, Müller U, Wünsch G, Kretzschmar H, Haass C, Herms J. O4-04-06 β-Amyloid precursor protein intracellular domain (AICD) strongly enhances resting free cytosolic calcium levels Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80277-X |
0.605 |
|
| 2004 |
Walter J, Prager K, Diallo M, Wahle T, Lütjohann D, Haass C, Sandhoff K, Schepers U, Tamboli I. O2-03-08 Glycosphingolipids regulate subcellular transport of the β-amyloid procursor protein and the generation of amyloid β-peptide Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80126-X |
0.329 |
|
| 2003 |
Capell A, Kaether C, Edbauer D, Shirotani K, Merkl S, Steiner H, Haass C. Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain. The Journal of Biological Chemistry. 278: 52519-23. PMID 14602727 DOI: 10.1074/Jbc.C300435200 |
0.661 |
|
| 2003 |
Aguzzi A, Haass C. Games played by rogue proteins in prion disorders and Alzheimer's disease. Science (New York, N.Y.). 302: 814-8. PMID 14593165 DOI: 10.1126/Science.1087348 |
0.587 |
|
| 2003 |
Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. The Journal of Biological Chemistry. 278: 48713-9. PMID 14507929 DOI: 10.1074/Jbc.M303861200 |
0.732 |
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| 2003 |
Marques CA, Keil U, Bonert A, Steiner B, Haass C, Muller WE, Eckert A. Neurotoxic mechanisms caused by the Alzheimer's disease-linked Swedish amyloid precursor protein mutation: oxidative stress, caspases, and the JNK pathway. The Journal of Biological Chemistry. 278: 28294-302. PMID 12730216 DOI: 10.1074/Jbc.M212265200 |
0.37 |
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| 2003 |
Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y. Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 24294-301. PMID 12707272 DOI: 10.1074/Jbc.M211161200 |
0.641 |
|
| 2003 |
Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Reconstitution of gamma-secretase activity. Nature Cell Biology. 5: 486-8. PMID 12679784 DOI: 10.1038/Ncb960 |
0.697 |
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| 2003 |
Shirotani K, Edbauer D, Capell A, Schmitz J, Steiner H, Haass C. Gamma-secretase activity is associated with a conformational change of nicastrin. The Journal of Biological Chemistry. 278: 16474-7. PMID 12644462 DOI: 10.1074/Jbc.C300095200 |
0.662 |
|
| 2003 |
Ehehalt R, Keller P, Haass C, Thiele C, Simons K. Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. The Journal of Cell Biology. 160: 113-23. PMID 12515826 DOI: 10.1083/Jcb.200207113 |
0.419 |
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| 2003 |
Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C. Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation. The Journal of Biological Chemistry. 278: 5531-8. PMID 12471021 DOI: 10.1074/Jbc.M211485200 |
0.716 |
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| 2003 |
Steiner H, Edbauer D, Shirotani K, Haass C. S.03.03 Characterization and reconstitution of gamma-secretase European Neuropsychopharmacology. 13: S101. DOI: 10.1016/S0924-977X(03)91607-5 |
0.562 |
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| 2002 |
Haass C, Steiner H. Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends in Cell Biology. 12: 556-62. PMID 12495843 DOI: 10.1016/S0962-8924(02)02394-2 |
0.376 |
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| 2002 |
Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Müller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C. Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. The Journal of Clinical Investigation. 110: 1429-39. PMID 12438441 DOI: 10.1172/Jci15777 |
0.395 |
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| 2002 |
Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C. Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. The Embo Journal. 21: 5408-16. PMID 12374741 DOI: 10.1093/Emboj/Cdf541 |
0.459 |
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| 2002 |
Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. The Journal of Biological Chemistry. 277: 44754-9. PMID 12223485 DOI: 10.1074/Jbc.M206872200 |
0.691 |
|
| 2002 |
Steiner H, Winkler E, Edbauer D, Prokop S, Basset G, Yamasaki A, Kostka M, Haass C. PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. The Journal of Biological Chemistry. 277: 39062-5. PMID 12198112 DOI: 10.1074/Jbc.C200469200 |
0.753 |
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| 2002 |
Kaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C. Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. The Journal of Cell Biology. 158: 551-61. PMID 12147673 DOI: 10.1083/Jcb.200201123 |
0.667 |
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| 2002 |
Geling A, Steiner H, Willem M, Bally-Cuif L, Haass C. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. Embo Reports. 3: 688-94. PMID 12101103 DOI: 10.1093/Embo-Reports/Kvf124 |
0.407 |
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| 2002 |
Fluhrer R, Capell A, Westmeyer G, Willem M, Hartung B, Condron MM, Teplow DB, Haass C, Walter J. A non-amyloidogenic function of BACE-2 in the secretory pathway. Journal of Neurochemistry. 81: 1011-20. PMID 12065613 DOI: 10.1046/J.1471-4159.2002.00908.X |
0.754 |
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| 2002 |
Leutz S, Steiner B, Marques CA, Haass C, Müller WE, Eckert A. Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death. Journal of Molecular Neuroscience : Mn. 18: 189-201. PMID 12059037 DOI: 10.1385/Jmn:18:3:189 |
0.336 |
|
| 2002 |
Edbauer D, Winkler E, Haass C, Steiner H. Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proceedings of the National Academy of Sciences of the United States of America. 99: 8666-71. PMID 12048259 DOI: 10.1073/Pnas.132277899 |
0.69 |
|
| 2002 |
Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proceedings of the National Academy of Sciences of the United States of America. 99: 8025-30. PMID 12048239 DOI: 10.1073/Pnas.112686799 |
0.696 |
|
| 2002 |
Thal DR, Ghebremedhin E, Haass C, Schultz C. UV light-induced autofluorescence of full-length Abeta-protein deposits in the human brain. Clinical Neuropathology. 21: 35-40. PMID 11846043 |
0.302 |
|
| 2002 |
Edbauer D, Willem M, Lammich S, Steiner H, Haass C. Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). The Journal of Biological Chemistry. 277: 13389-93. PMID 11809755 DOI: 10.1074/Jbc.M111571200 |
0.673 |
|
| 2002 |
Capell A, Meyn L, Fluhrer R, Teplow DB, Walter J, Haass C. Apical sorting of beta-secretase limits amyloid beta-peptide production. The Journal of Biological Chemistry. 277: 5637-43. PMID 11741885 DOI: 10.1074/Jbc.M109119200 |
0.433 |
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| 2002 |
Walter J, Haass C. Secretases as targets for beta-amyloid lowering drugs Drug Development Research. 56: 201-210. DOI: 10.1002/Ddr.10076 |
0.45 |
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| 2001 |
Kahle PJ, Haass C. The emerging utility of animal models of chronic neurodegenerative diseases. Expert Opinion On Therapeutic Targets. 5: 125-32. PMID 15992171 DOI: 10.1517/14728222.5.1.125 |
0.41 |
|
| 2001 |
Steiner H, Haass C. Nuclear signaling: a common function of presenilin substrates? Journal of Molecular Neuroscience : Mn. 17: 193-8. PMID 11816792 DOI: 10.1385/JMN:17:2:193 |
0.387 |
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| 2001 |
Kahle PJ, Neumann M, Ozmen L, Müller V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. The American Journal of Pathology. 159: 2215-25. PMID 11733371 DOI: 10.1016/S0002-9440(10)63072-6 |
0.452 |
|
| 2001 |
Walter J, Kaether C, Steiner H, Haass C. The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Current Opinion in Neurobiology. 11: 585-90. PMID 11595492 DOI: 10.1016/S0959-4388(00)00253-1 |
0.475 |
|
| 2001 |
Haass C, Steiner H. Protofibrils, the unifying toxic molecule of neurodegenerative disorders? Nature Neuroscience. 4: 859-60. PMID 11528409 DOI: 10.1038/Nn0901-859 |
0.392 |
|
| 2001 |
Sastre M, Steiner H, Fuchs K, Capell A, Multhaup G, Condron MM, Teplow DB, Haass C. Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. Embo Reports. 2: 835-41. PMID 11520861 DOI: 10.1093/Embo-Reports/Kve180 |
0.456 |
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| 2001 |
Steiner H, Winkler E, Shearman MS, Prywes R, Haass C. Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins. Neurobiology of Disease. 8: 717-22. PMID 11493036 DOI: 10.1006/Nbdi.2001.0405 |
0.461 |
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| 2001 |
Rathke-Hartlieb S, Kahle PJ, Neumann M, Ozmen L, Haid S, Okochi M, Haass C, Schulz JB. Sensitivity to MPTP is not increased in Parkinson's disease-associated mutant alpha-synuclein transgenic mice. Journal of Neurochemistry. 77: 1181-4. PMID 11359883 DOI: 10.1046/J.1471-4159.2001.00366.X |
0.318 |
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| 2001 |
Eckert A, Steiner B, Marques C, Leutz S, Romig H, Haass C, Müller WE. Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation. Journal of Neuroscience Research. 64: 183-92. PMID 11288146 DOI: 10.1002/Jnr.1064 |
0.327 |
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| 2001 |
Walter J, Fluhrer R, Hartung B, Willem M, Kaether C, Capell A, Lammich S, Multhaup G, Haass C. Phosphorylation regulates intracellular trafficking of beta-secretase. The Journal of Biological Chemistry. 276: 14634-41. PMID 11278841 DOI: 10.1074/Jbc.M011116200 |
0.413 |
|
| 2001 |
Yamazaki T, Chang TY, Haass C, Ihara Y. Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. The Journal of Biological Chemistry. 276: 4454-60. PMID 11085995 DOI: 10.1074/Jbc.M009598200 |
0.425 |
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| 2001 |
Steiner H, Revesz T, Neumann M, Romig H, Grim MG, Pesold B, Kretzschmar HA, Hardy J, Holton JL, Baumeister R, Houlden H, Haass C. A pathogenic presenilin-1 deletion causes abberrant Abeta 42 production in the absence of congophilic amyloid plaques. The Journal of Biological Chemistry. 276: 7233-9. PMID 11084029 DOI: 10.1074/Jbc.M007183200 |
0.479 |
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| 2000 |
Walter J, Haass C. Posttranslational modifications of amyloid precursor protein : ectodomain phosphorylation and sulfation. Methods in Molecular Medicine. 32: 149-68. PMID 21318517 DOI: 10.1385/1-59259-195-7:149 |
0.383 |
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| 2000 |
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser P, Haass C, et al. Mutation of conserved aspartates affect maturation of presenilin 1 and presenilin 2 complexes. Acta Neurologica Scandinavica. Supplementum. 176: 6-11. PMID 11261807 DOI: 10.1034/J.1600-0404.2000.00301.X |
0.31 |
|
| 2000 |
Steiner H, Haass C. Intramembrane proteolysis by presenilins. Nature Reviews. Molecular Cell Biology. 1: 217-24. PMID 11252897 DOI: 10.1038/35043065 |
0.446 |
|
| 2000 |
Kahle PJ, Neumann M, Ozmen L, Haass C. Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein. Annals of the New York Academy of Sciences. 920: 33-41. PMID 11193173 DOI: 10.1111/J.1749-6632.2000.Tb06902.X |
0.328 |
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| 2000 |
Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, et al. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. Molecular Medicine (Cambridge, Mass.). 6: 878-91. PMID 11126202 DOI: 10.1007/Bf03401825 |
0.379 |
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| 2000 |
Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA. Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of A beta plaques. Neuroreport. 11: 3737-41. PMID 11117482 DOI: 10.1097/00001756-200011270-00029 |
0.427 |
|
| 2000 |
Steiner H, Kostka M, Romig H, Basset G, Pesold B, Hardy J, Capell A, Meyn L, Grim ML, Baumeister R, Fechteler K, Haass C. Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nature Cell Biology. 2: 848-51. PMID 11056541 DOI: 10.1038/35041097 |
0.404 |
|
| 2000 |
Okochi M, Eimer S, Bottcher A, Baumeister R, Romig H, Walter J, Capell A, Steiner H, Haass C. A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. The Journal of Biological Chemistry. 275: 40925-32. PMID 11013240 DOI: 10.1074/Jbc.M005254200 |
0.408 |
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| 2000 |
Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Schindzielorz A, Okochi M, Leimer U, van Der Putten H, Probst A, Kremmer E, Kretzschmar HA, Haass C. Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6365-73. PMID 10964942 DOI: 10.1523/Jneurosci.20-17-06365.2000 |
0.34 |
|
| 2000 |
Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, et al. Mutation of conserved aspartates affects maturation of both aspartate mutant and endogenous presenilin 1 and presenilin 2 complexes. The Journal of Biological Chemistry. 275: 27348-53. PMID 10856299 DOI: 10.1074/Jbc.M002982200 |
0.352 |
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| 2000 |
Kulic L, Walter J, Multhaup G, Teplow DB, Baumeister R, Romig H, Capell A, Steiner H, Haass C. Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch. Proceedings of the National Academy of Sciences of the United States of America. 97: 5913-8. PMID 10811883 DOI: 10.1073/Pnas.100049897 |
0.443 |
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| 2000 |
Walter J, Schindzielorz A, Hartung B, Haass C. Phosphorylation of the beta-amyloid precursor protein at the cell surface by ectocasein kinases 1 and 2. The Journal of Biological Chemistry. 275: 23523-9. PMID 10806211 DOI: 10.1074/Jbc.M002850200 |
0.301 |
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| 2000 |
Capell A, Steiner H, Willem M, Kaiser H, Meyer C, Walter J, Lammich S, Multhaup G, Haass C. Maturation and pro-peptide cleavage of beta-secretase. The Journal of Biological Chemistry. 275: 30849-54. PMID 10801872 DOI: 10.1074/Jbc.M003202200 |
0.393 |
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| 2000 |
Capell A, Steiner H, Romig H, Keck S, Baader M, Grim MG, Baumeister R, Haass C. Presenilin-1 differentially facilitates endoproteolysis of the beta-amyloid precursor protein and Notch. Nature Cell Biology. 2: 205-11. PMID 10783238 DOI: 10.1038/35008626 |
0.467 |
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| 2000 |
Haass C, Kahle PJ. Parkinson's pathology in a fly. Nature. 404: 341, 343. PMID 10746706 DOI: 10.1038/35006188 |
0.307 |
|
| 2000 |
Hayashi H, Mizuno T, Michikawa M, Haass C, Yanagisawa K. Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains. Biochimica Et Biophysica Acta. 1483: 81-90. PMID 10601697 DOI: 10.1016/S1388-1981(99)00174-2 |
0.331 |
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| 2000 |
Haass C, Kulic L, Capell A, Steiner H, Multhaup G, Teplow D, Romig H. Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch Neurobiology of Aging. 21: 141. DOI: 10.1016/S0197-4580(00)82432-X |
0.321 |
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| 1999 |
Haass C, Baumeister R. The biological and pathological function of presenilin proteins--simple cell systems and a worm in Alzheimer's disease research. European Archives of Psychiatry and Clinical Neuroscience. 249: 23-7. PMID 10654096 DOI: 10.1007/Pl00014169 |
0.434 |
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| 1999 |
Steiner H, Capell A, Leimer U, Haass C. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 249: 266-70. PMID 10653281 DOI: 10.1007/S004060050098 |
0.486 |
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| 1999 |
Haass C. Biology of Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 249: 265. PMID 10653280 DOI: 10.1007/S004060050097 |
0.362 |
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| 1999 |
Steiner H, Pesold B, Haass C. An in vivo assay for the identification of target proteases which cleave membrane-associated substrates. Febs Letters. 463: 245-9. PMID 10606730 DOI: 10.1016/S0014-5793(99)01627-0 |
0.425 |
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| 1999 |
Steiner H, Romig H, Pesold B, Philipp U, Baader M, Citron M, Loetscher H, Jacobsen H, Haass C. Amyloidogenic function of the Alzheimer's disease-associated presenilin 1 in the absence of endoproteolysis. Biochemistry. 38: 14600-5. PMID 10545183 DOI: 10.1021/Bi9914210 |
0.444 |
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| 1999 |
Haass C, De Strooper B. The presenilins in Alzheimer's disease--proteolysis holds the key. Science (New York, N.Y.). 286: 916-9. PMID 10542139 DOI: 10.1126/Science.286.5441.916 |
0.492 |
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| 1999 |
Leimer U, Lun K, Romig H, Walter J, Grünberg J, Brand M, Haass C. Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis. Biochemistry. 38: 13602-9. PMID 10521267 DOI: 10.1021/Bi991453N |
0.487 |
|
| 1999 |
Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, ... ... Haass C, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669 |
0.465 |
|
| 1999 |
Guénette SY, Chen J, Ferland A, Haass C, Capell A, Tanzi RE. hFE65L influences amyloid precursor protein maturation and secretion. Journal of Neurochemistry. 73: 985-93. PMID 10461887 DOI: 10.1046/J.1471-4159.1999.0730985.X |
0.44 |
|
| 1999 |
Haass C, Mandelkow E. Proteolysis by presenilins and the renaissance of tau. Trends in Cell Biology. 9: 241-4. PMID 10408925 DOI: 10.1016/S0962-8924(99)01576-7 |
0.428 |
|
| 1999 |
Haass C. Apoptosis. Dead end for neurodegeneration? Nature. 399: 204-5, 207. PMID 10353238 DOI: 10.1038/20314 |
0.432 |
|
| 1999 |
Diehlmann A, Ida N, Weggen S, Grünberg J, Haass C, Masters CL, Bayer TA, Beyreuther K. Analysis of presenilin 1 and presenilin 2 expression and processing by newly developed monoclonal antibodies. Journal of Neuroscience Research. 56: 405-19. PMID 10340748 DOI: 10.1002/(Sici)1097-4547(19990515)56:4<405::Aid-Jnr8>3.0.Co;2-F |
0.422 |
|
| 1999 |
Mizuno T, Nakata M, Naiki H, Michikawa M, Wang R, Haass C, Yanagisawa K. Cholesterol-dependent generation of a seeding amyloid beta-protein in cell culture. The Journal of Biological Chemistry. 274: 15110-4. PMID 10329717 DOI: 10.1074/Jbc.274.21.15110 |
0.45 |
|
| 1999 |
Lammich S, Kojro E, Postina R, Gilbert S, Pfeiffer R, Jasionowski M, Haass C, Fahrenholz F. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Proceedings of the National Academy of Sciences of the United States of America. 96: 3922-7. PMID 10097139 DOI: 10.1073/Pnas.96.7.3922 |
0.449 |
|
| 1999 |
Steiner H, Capell A, Haass C. Proteolytic processing and degradation of Alzheimer's disease relevant proteins. Biochemical Society Transactions. 27: 234-42. PMID 10093740 DOI: 10.1042/Bst0270234 |
0.386 |
|
| 1999 |
Steiner H, Romig H, Grim MG, Philipp U, Pesold B, Citron M, Baumeister R, Haass C. The biological and pathological function of the presenilin-1 Deltaexon 9 mutation is independent of its defect to undergo proteolytic processing. The Journal of Biological Chemistry. 274: 7615-8. PMID 10075646 DOI: 10.1074/Jbc.274.12.7615 |
0.452 |
|
| 1999 |
Thal DR, Sassin I, Schultz C, Haass C, Braak E, Braak H. Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta. Journal of Neuropathology and Experimental Neurology. 58: 210-6. PMID 10029103 DOI: 10.1097/00005072-199902000-00010 |
0.428 |
|
| 1999 |
Walter J, Schindzielorz A, Grünberg J, Haass C. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 96: 1391-6. PMID 9990034 DOI: 10.1073/Pnas.96.4.1391 |
0.357 |
|
| 1999 |
Steiner H, Haass C. Proteolytic processing of β-amyloid precursor protein and presenilins Biochemical Society Transactions. 27: A23-A23. DOI: 10.1042/Bst027A023C |
0.349 |
|
| 1998 |
Haass C, Baumeister R. What do we learn from a few familial Alzheimer's disease cases? Journal of Neural Transmission. Supplementum. 54: 137-45. PMID 9850922 DOI: 10.1007/978-3-7091-7508-8_13 |
0.427 |
|
| 1998 |
Grünberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C. Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. Neuroreport. 9: 3293-9. PMID 9831466 DOI: 10.1097/00001756-199810050-00027 |
0.453 |
|
| 1998 |
Steiner H, Capell A, Pesold B, Citron M, Kloetzel PM, Selkoe DJ, Romig H, Mendla K, Haass C. Expression of Alzheimer's disease-associated presenilin-1 is controlled by proteolytic degradation and complex formation. The Journal of Biological Chemistry. 273: 32322-31. PMID 9822712 DOI: 10.1074/Jbc.273.48.32322 |
0.678 |
|
| 1998 |
Mizuno T, Haass C, Michikawa M, Yanagisawa K. Cholesterol-dependent generation of a unique amyloid beta-protein from apically missorted amyloid precursor protein in MDCK cells. Biochimica Et Biophysica Acta. 1373: 119-30. PMID 9733943 DOI: 10.1016/S0005-2736(98)00097-2 |
0.427 |
|
| 1998 |
Haass C, Grünberg J, Capell A, Wild-Bode C, Leimer U, Walter J, Yamazaki T, Ihara I, Zweckbronner I, Jakubek C, Baumeister R. Proteolytic processing of Alzheimer's disease associated proteins. Journal of Neural Transmission. Supplementum. 53: 159-67. PMID 9700654 DOI: 10.1007/978-3-7091-6467-9_14 |
0.445 |
|
| 1998 |
Oyama F, Sawamura N, Kobayashi K, Morishima-Kawashima M, Kuramochi T, Ito M, Tomita T, Maruyama K, Saido TC, Iwatsubo T, Capell A, Walter J, Grünberg J, Ueyama Y, Haass C, et al. Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain. Journal of Neurochemistry. 71: 313-22. PMID 9648880 DOI: 10.1046/J.1471-4159.1998.71010313.X |
0.411 |
|
| 1998 |
Brockhaus M, Grünberg J, Röhrig S, Loetscher H, Wittenburg N, Baumeister R, Jacobsen H, Haass C. Caspase-mediated cleavage is not required for the activity of presenilins in amyloidogenesis and NOTCH signaling. Neuroreport. 9: 1481-6. PMID 9631452 DOI: 10.1097/00001756-199805110-00043 |
0.391 |
|
| 1998 |
Walter J, Grünberg J, Schindzielorz A, Haass C. Proteolytic fragments of the Alzheimer's disease associated presenilins-1 and -2 are phosphorylated in vivo by distinct cellular mechanisms. Biochemistry. 37: 5961-7. PMID 9558331 DOI: 10.1021/Bi971763A |
0.321 |
|
| 1998 |
Grunberg J, Walter J, Loetscher H, Deuschle U, Jacobsen H, Haass C. Alzheimer's disease associated presenilin-1 holoprotein and its 18-20 kDa C-terminal fragment are death substrates for proteases of the caspase family. Biochemistry. 37: 2263-70. PMID 9485372 DOI: 10.1021/Bi972106L |
0.367 |
|
| 1998 |
Capell A, Grünberg J, Pesold B, Diehlmann A, Citron M, Nixon R, Beyreuther K, Selkoe DJ, Haass C. The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex. The Journal of Biological Chemistry. 273: 3205-11. PMID 9452432 DOI: 10.1074/Jbc.273.6.3205 |
0.605 |
|
| 1998 |
Haass C, Selkoe DJ. Alzheimer's disease. A technical KO of amyloid-beta peptide. Nature. 391: 339-40. PMID 9450743 DOI: 10.1038/34800 |
0.678 |
|
| 1997 |
Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation. Journal of Neurochemistry. 69: 2432-40. PMID 9375676 DOI: 10.1046/J.1471-4159.1997.69062432.X |
0.351 |
|
| 1997 |
Kim SH, Kim YK, Jeong SJ, Haass C, Kim YH, Suh YH. Enhanced release of secreted form of Alzheimer's amyloid precursor protein from PC12 cells by nicotine. Molecular Pharmacology. 52: 430-6. PMID 9281605 DOI: 10.1124/Mol.52.3.430 |
0.351 |
|
| 1997 |
Loetscher H, Deuschle U, Brockhaus M, Reinhardt D, Nelboeck P, Mous J, Grünberg J, Haass C, Jacobsen H. Presenilins are processed by caspase-type proteases. The Journal of Biological Chemistry. 272: 20655-9. PMID 9252383 DOI: 10.1074/Jbc.272.33.20655 |
0.334 |
|
| 1997 |
Yamazaki T, Haass C, Saido TC, Omura S, Ihara Y. Specific increase in amyloid beta-protein 42 secretion ratio by calpain inhibition. Biochemistry. 36: 8377-83. PMID 9204885 DOI: 10.1021/Bi970209Y |
0.446 |
|
| 1997 |
Haass C. Presenilins: genes for life and death. Neuron. 18: 687-90. PMID 9182794 DOI: 10.1016/S0896-6273(00)80309-8 |
0.394 |
|
| 1997 |
Podlisny MB, Citron M, Amarante P, Sherrington R, Xia W, Zhang J, Diehl T, Levesque G, Fraser P, Haass C, Koo EH, Seubert P, St George-Hyslop P, Teplow DB, Selkoe DJ. Presenilin proteins undergo heterogeneous endoproteolysis between Thr291 and Ala299 and occur as stable N- and C-terminal fragments in normal and Alzheimer brain tissue. Neurobiology of Disease. 3: 325-37. PMID 9173929 DOI: 10.1006/Nbdi.1997.0129 |
0.734 |
|
| 1997 |
Walter J, Grünberg J, Capell A, Pesold B, Schindzielorz A, Citron M, Mendla K, George-Hyslop PS, Multhaup G, Selkoe DJ, Haass C. Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 94: 5349-54. PMID 9144240 DOI: 10.1073/Pnas.94.10.5349 |
0.606 |
|
| 1997 |
Xia W, Zhang J, Kholodenko D, Citron M, Podlisny MB, Teplow DB, Haass C, Seubert P, Koo EH, Selkoe DJ. Enhanced production and oligomerization of the 42-residue amyloid beta-protein by Chinese hamster ovary cells stably expressing mutant presenilins. The Journal of Biological Chemistry. 272: 7977-82. PMID 9065468 DOI: 10.1074/Jbc.272.12.7977 |
0.751 |
|
| 1997 |
Tomita T, Maruyama K, Saido TC, Kume H, Shinozaki K, Tokuhiro S, Capell A, Walter J, Grünberg J, Haass C, Iwatsubo T, Obata K. The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue. Proceedings of the National Academy of Sciences of the United States of America. 94: 2025-30. PMID 9050898 DOI: 10.1073/Pnas.94.5.2025 |
0.445 |
|
| 1997 |
Walter J, Capell A, Hung AY, Langen H, Schnölzer M, Thinakaran G, Sisodia SS, Selkoe DJ, Haass C. Ectodomain phosphorylation of beta-amyloid precursor protein at two distinct cellular locations. The Journal of Biological Chemistry. 272: 1896-903. PMID 8999878 DOI: 10.1074/Jbc.272.3.1896 |
0.614 |
|
| 1996 |
Walter J, Capell A, Grünberg J, Pesold B, Schindzielorz A, Prior R, Podlisny MB, Fraser P, Hyslop PS, Selkoe DJ, Haass C. The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum. Molecular Medicine (Cambridge, Mass.). 2: 673-91. PMID 8972483 DOI: 10.1007/Bf03401652 |
0.674 |
|
| 1996 |
Haass C. Presenile because of presenilin: the presenilin genes and early onset Alzheimer's disease. Current Opinion in Neurology. 9: 254-9. PMID 8858181 DOI: 10.1097/00019052-199608000-00002 |
0.428 |
|
| 1996 |
Citron M, Diehl TS, Capell A, Haass C, Teplow DB, Selkoe DJ. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron. 17: 171-9. PMID 8755488 DOI: 10.1016/S0896-6273(00)80290-1 |
0.625 |
|
| 1996 |
Haass C. The molecular significance of amyloid beta-peptide for Alzheimer's disease. European Archives of Psychiatry and Clinical Neuroscience. 246: 118-23. PMID 8739395 DOI: 10.1007/Bf02189111 |
0.455 |
|
| 1996 |
Qiu WQ, Borth W, Ye Z, Haass C, Teplow DB, Selkoe DJ. Degradation of amyloid beta-protein by a serine protease-alpha2-macroglobulin complex. The Journal of Biological Chemistry. 271: 8443-51. PMID 8626544 DOI: 10.1074/Jbc.271.14.8443 |
0.679 |
|
| 1996 |
Selkoe DJ, Yamazaki T, Citron M, Podlisny MB, Koo EH, Teplow DB, Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Annals of the New York Academy of Sciences. 777: 57-64. PMID 8624127 DOI: 10.1111/J.1749-6632.1996.Tb34401.X |
0.717 |
|
| 1996 |
Capell A, Teplow DB, Citron M, Selkoe DJ, Haass C. Substitution of phenylalanine by proline at position 19 of amyloid β peptide results in an increased production of amyloid β peptides with alternative N-termini after protein kinase C stimulation Amyloid. 3: 150-155. DOI: 10.3109/13506129609045514 |
0.632 |
|
| 1996 |
Haass C. All about alzheimer's disease: A report on the 25th annual meeting of the society for neuroscience, San Diego, November 11–16, 1995 Amyloid. 3: 59-63. DOI: 10.3109/13506129609014356 |
0.317 |
|
| 1996 |
Citron M, Xia W, Diehl T, Podlisny M, Sherrington R, Haass C, Seubert P, Hyslop P, Selkoe D. 320 Effect of presenilin mutations on BAPP processing in presenilin transfected cells Neurobiology of Aging. 17: S81. DOI: 10.1016/S0197-4580(96)80322-8 |
0.557 |
|
| 1996 |
Haass C, Walter J, Grünberg J, George-Hyslop PS, Selkoe D, Pesold B, Capell A. 150 Expression of the Presenilin proteins PS-1 and PS-2 in tissue culture cells Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80152-7 |
0.564 |
|
| 1995 |
Haass C, Capell A, Citron M, Teplow DB, Selkoe DJ. The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein. The Journal of Biological Chemistry. 270: 6186-92. PMID 7890753 DOI: 10.1074/Jbc.270.11.6186 |
0.631 |
|
| 1995 |
Haass C, Koo EH, Capell A, Teplow DB, Selkoe DJ. Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals. The Journal of Cell Biology. 128: 537-47. PMID 7860629 DOI: 10.1083/Jcb.128.4.537 |
0.717 |
|
| 1995 |
Lemere CA, Munger JS, Shi GP, Natkin L, Haass C, Chapman HA, Selkoe DJ. The lysosomal cysteine protease, cathepsin S, is increased in Alzheimer's disease and Down syndrome brain. An immunocytochemical study. The American Journal of Pathology. 146: 848-60. PMID 7717452 |
0.601 |
|
| 1995 |
Munger JS, Haass C, Lemere CA, Shi GP, Wong WS, Teplow DB, Selkoe DJ, Chapman HA. Lysosomal processing of amyloid precursor protein to A beta peptides: a distinct role for cathepsin S. The Biochemical Journal. 311: 299-305. PMID 7575468 DOI: 10.1042/Bj3110299 |
0.643 |
|
| 1995 |
Haass C, Lemere CA, Capell A, Citron M, Seubert P, Schenk D, Lannfelt L, Selkoe DJ. The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nature Medicine. 1: 1291-6. PMID 7489411 DOI: 10.1038/Nm1295-1291 |
0.627 |
|
| 1994 |
Haass C, Koo EH, Teplow DB, Selkoe DJ. Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 1564-8. PMID 8108445 DOI: 10.1073/Pnas.91.4.1564 |
0.72 |
|
| 1994 |
Haass C, Hung AY, Selkoe DJ, Teplow DB. Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 17741-8. PMID 8021287 |
0.618 |
|
| 1994 |
Lo AC, Haass C, Wagner SL, Teplow DB, Sisodia SS. Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 269: 30966-73. PMID 7983032 |
0.321 |
|
| 1993 |
Haass C, Hung AY, Schlossmacher MG, Teplow DB, Selkoe DJ. beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms. The Journal of Biological Chemistry. 268: 3021-4. PMID 8428976 |
0.589 |
|
| 1993 |
Citron M, Haass C, Selkoe DJ. Production of amyloid-beta-peptide by cultured cells: no evidence for internal initiation of translation at Met596. Neurobiology of Aging. 14: 571-3. PMID 8295660 DOI: 10.1016/0197-4580(93)90041-9 |
0.632 |
|
| 1993 |
Haass C, Selkoe DJ. Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell. 75: 1039-42. PMID 8261505 DOI: 10.1016/0092-8674(93)90312-E |
0.676 |
|
| 1993 |
Haass C, Hung AY, Schlossmacher MG, Oltersdorf T, Teplow DB, Selkoe DJ. Normal cellular processing of the beta-amyloid precursor protein results in the secretion of the amyloid beta peptide and related molecules. Annals of the New York Academy of Sciences. 695: 109-16. PMID 8239267 DOI: 10.1111/J.1749-6632.1993.Tb23037.X |
0.634 |
|
| 1993 |
Hung AY, Haass C, Nitsch RM, Qiu WQ, Citron M, Wurtman RJ, Growdon JH, Selkoe DJ. Activation of protein kinase C inhibits cellular production of the amyloid beta-protein. The Journal of Biological Chemistry. 268: 22959-62. PMID 8226807 |
0.617 |
|
| 1992 |
Schlossmacher MG, Ostaszewski BL, Hecker LI, Celi A, Haass C, Chin D, Lieberburg I, Furie BC, Furie B, Selkoe DJ. Detection of distinct isoform patterns of the beta-amyloid precursor protein in human platelets and lymphocytes. Neurobiology of Aging. 13: 421-34. PMID 1625772 DOI: 10.1016/0197-4580(92)90117-G |
0.641 |
|
| 1992 |
Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ. Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments. Nature. 357: 500-3. PMID 1608449 DOI: 10.1038/357500A0 |
0.727 |
|
| 1992 |
Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 360: 672-4. PMID 1465129 DOI: 10.1038/360672A0 |
0.658 |
|
| 1992 |
Hung AY, Koo EH, Haass C, Selkoe DJ. Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage. Proceedings of the National Academy of Sciences of the United States of America. 89: 9439-43. PMID 1409654 DOI: 10.1073/Pnas.89.20.9439 |
0.721 |
|
| 1992 |
Haass C, Schlossmacher MG, Hung AY, Vigo-Pelfrey C, Mellon A, Ostaszewski BL, Lieberburg I, Koo EH, Schenk D, Teplow DB. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature. 359: 322-5. PMID 1383826 DOI: 10.1038/359322A0 |
0.611 |
|
| 1991 |
Haass C, Hung AY, Selkoe DJ. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 3783-93. PMID 1744690 DOI: 10.1523/Jneurosci.11-12-03783.1991 |
0.641 |
|
| 1991 |
Haass C, Hung A, Selkoe D. Processing of beta-amyloid precursor protein in microglia and astrocytes favors an internal localization over constitutive secretion The Journal of Neuroscience. 11: 3783-3793. DOI: 10.1523/JNEUROSCI.11-12-03783.1991 |
0.597 |
|
| 1989 |
Haass C, Pesold-Hurt B, Multhaup G, Beyreuther K, Kloetzel P. The PROS-35 gene encodes the 35 kd protein subunit of Drosophila melanogaster proteasome. The Embo Journal. 8: 2373-2379. DOI: 10.1002/J.1460-2075.1989.Tb08366.X |
0.308 |
|
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