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Christian Haass, PhD, University of Heidelberg 1989 - Related publications

Biochemistry Ludwig-Maximilians-Universität München, München, Bayern, Germany 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Chen XQ, Salehi A, Pearn ML, Overk C, Nguyen PD, Kleschevnikov AM, Maccecchini M, Mobley WC. Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32975365 DOI: 10.1002/alz.12185   
2020 Verberk IMW, Thijssen E, Koelewijn J, Mauroo K, Vanbrabant J, de Wilde A, Zwan MD, Verfaillie SCJ, Ossenkoppele R, Barkhof F, van Berckel BNM, Scheltens P, van der Flier WM, Stoops E, Vanderstichele HM, et al. Combination of plasma amyloid beta and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology. Alzheimer's Research & Therapy. 12: 118. PMID 32988409 DOI: 10.1186/s13195-020-00682-7   
2020 Qu X, Guan P, Han L, Wang Z, Huang X. Levistolide A Attenuates Alzheimer's Pathology Through Activation of the PPARγ Pathway. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 33034847 DOI: 10.1007/s13311-020-00943-1   
2020 Narayanan SE, Sekhar N, Rajamma RG, Marathakam A, Al Mamun A, Uddin MS, Mathew B. Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer's Disease. Current Protein & Peptide Science. PMID 32957903 DOI: 10.2174/1389203721666200921152246   
2020 Thompson TB, Chaggar P, Kuhl E, Goriely A, . Protein-protein interactions in neurodegenerative diseases: A conspiracy theory. Plos Computational Biology. 16: e1008267. PMID 33048932 DOI: 10.1371/journal.pcbi.1008267   
2020 Mo D, Li X, Raabe CA, Rozhdestvensky TS, Skryabin BV, Brosius J. Circular RNA Encoded Amyloid Beta peptides-A Novel Putative Player in Alzheimer's Disease. Cells. 9. PMID 33003364 DOI: 10.3390/cells9102196   
2020 Ma Y, McClatchy DB, Martínez-Bartolomé S, Bamberger C, Yates JR. Temporal Quantitative Profiling of Newly Synthesized Proteins during Aβ Accumulation. Journal of Proteome Research. PMID 33147027 DOI: 10.1021/acs.jproteome.0c00645   
2020 Barman NC, Khan NM, Islam M, Nain Z, Roy RK, Haque A, Barman SK. CRISPR-Cas9: A Promising Genome Editing Therapeutic Tool for Alzheimer's Disease-A Narrative Review. Neurology and Therapy. PMID 33089409 DOI: 10.1007/s40120-020-00218-z   
2020 Ma WH, Chen AF, Xie XY, Huang YS. Sigma ligands as potent inhibitors of Aβ and AβOs in neurons and promising therapeutic agents of Alzheimer's disease. Neuropharmacology. 108342. PMID 33045243 DOI: 10.1016/j.neuropharm.2020.108342   
2020 Zhang T, Dong K, Xiao L, Li G, Zhang Z. Effects of Co-Administration of Icariin and Saponins on Intestinal Microbiota and Hippocampal Protein Expression in a Mouse Model of Alzheimer's Disease. Neuropsychiatric Disease and Treatment. 16: 2169-2179. PMID 33061388 DOI: 10.2147/NDT.S253972   
2020 Moynier F, Borgne ML, Laoud E, Mahan B, Mouton-Ligier F, Hugon J, Paquet C. Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12112. PMID 33102682 DOI: 10.1002/dad2.12112   
2020 Yan M, Wang X, Guo X. [Progress on loss-of-function hypothesis of presenilin-1 mutations in Alzheimer diseases]. Zhejiang Da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 49: 487-499. PMID 32985163 DOI: 10.3785/j.issn.1008-9292.2020.08.03   
2020 Ju Y, Chakravarty H, Tam KY. An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid β Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. Acs Chemical Neuroscience. PMID 33001625 DOI: 10.1021/acschemneuro.0c00464   
2020 Wu J, Cao C, Loch RA, Tiiman A, Luo J. Single-molecule studies of amyloid proteins: from biophysical properties to diagnostic perspectives. Quarterly Reviews of Biophysics. 53: e12. PMID 33148356 DOI: 10.1017/S0033583520000086   
2020 Keshavan A, Wellington H, Chen Z, Khatun A, Chapman M, Hart M, Cash DM, Coath W, Parker TD, Buchanan SM, Keuss SE, Harris MJ, Murray-Smith H, Heslegrave A, Fox NC, et al. Concordance of CSF measures of Alzheimer's pathology with amyloid PET status in a preclinical cohort: A comparison of Lumipulse and established immunoassays. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12097. PMID 32999915 DOI: 10.1002/dad2.12097   
2020 Beg AZ, Khan AU. Motifs and interface amino acid-mediated regulation of amyloid biogenesis in microbes to humans: potential targets for intervention. Biophysical Reviews. PMID 32930961 DOI: 10.1007/s12551-020-00759-5   
2020 Gu H, Territo PR, Persohn SA, Bedwell AA, Eldridge K, Speedy R, Chen Z, Zheng W, Du Y. Evaluation of chronic lead effects in the blood brain barrier system by DCE-CT. Journal of Trace Elements in Medicine and Biology : Organ of the Society For Minerals and Trace Elements (Gms). 62: 126648. PMID 32980769 DOI: 10.1016/j.jtemb.2020.126648   
2020 Das S, Sengupta S, Chakraborty S. Scope of β-Secretase (BACE1)-Targeted Therapy in Alzheimer's Disease: Emphasizing the Flavonoid Based Natural Scaffold for BACE1 Inhibition. Acs Chemical Neuroscience. PMID 33073981 DOI: 10.1021/acschemneuro.0c00579   
2020 Tudorascu DL, Laymon CM, Zammit M, Minhas DS, Anderson SJ, Ellison PA, Zaman S, Ances BM, Sabbagh M, Johnson SC, Mathis CA, Klunk WE, Handen BL, Christian BT, Cohen AD. Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline. Alzheimer's & Dementia (New York, N. Y.). 6: e12096. PMID 33163613 DOI: 10.1002/trc2.12096   
2020 Rivera-Marrero S, Bencomo-Martínez A, Orta Salazar E, Sablón-Carrazana M, García-Pupo L, Zoppolo F, Arredondo F, Dapueto R, Daniela Santi M, Kreimerman I, Pardo T, Reyes L, Galán L, León-Chaviano S, Espinosa-Rodríguez LA, et al. A new naphthalene derivative with anti-amyloidogenic activity as potential therapeutic agent for Alzheimer's disease. Bioorganic & Medicinal Chemistry. 28: 115700. PMID 33069076 DOI: 10.1016/j.bmc.2020.115700   
2020 Benson MD, Buxbaum JN, Eisenberg DS, Merlini G, Saraiva MJM, Sekijima Y, Sipe JD, Westermark P. Amyloid nomenclature 2020: update and recommendations by the International Society of Amyloidosis (ISA) nomenclature committee. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 1-6. PMID 33100054 DOI: 10.1080/13506129.2020.1835263   
2020 Zhou Y, Zhu F, Liu Y, Zheng M, Wang Y, Zhang D, Anraku Y, Zou Y, Li J, Wu H, Pang X, Tao W, Shimoni O, Bush AI, Xue X, et al. Blood-brain barrier-penetrating siRNA nanomedicine for Alzheimer's disease therapy. Science Advances. 6. PMID 33036977 DOI: 10.1126/sciadv.abc7031   
2020 Dadar M, Camicioli R, Duchesne S, Collins DL, . The temporal relationships between white matter hyperintensities, neurodegeneration, amyloid beta, and cognition. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12091. PMID 33083512 DOI: 10.1002/dad2.12091   
2020 Mitra A, Sarkar N. Sequence and structure-based peptides as potent amyloid inhibitors: A review. Archives of Biochemistry and Biophysics. 108614. PMID 33010227 DOI: 10.1016/   
2020 Tackenberg C, Kulic L, Nitsch RM. Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system. Plos One. 15: e0239584. PMID 32966331 DOI: 10.1371/journal.pone.0239584   
2020 Goyal MS, Gordon BA, Couture LE, Flores S, Xiong C, Morris JC, Raichle ME, L-S Benzinger T, Vlassenko AG. Spatiotemporal relationship between subthreshold amyloid accumulation and aerobic glycolysis in the human brain. Neurobiology of Aging. 96: 165-175. PMID 33011615 DOI: 10.1016/j.neurobiolaging.2020.08.019   
2020 Garcia-Leon JA, Caceres-Palomo L, Sanchez-Mejias E, Mejias-Ortega M, Nuñez-Diaz C, Fernandez-Valenzuela JJ, Sanchez-Varo R, Davila JC, Vitorica J, Gutierrez A. Human Pluripotent Stem Cell-Derived Neural Cells as a Relevant Platform for Drug Screening in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32962164 DOI: 10.3390/ijms21186867   
2020 Uttamapinant C, Suppakhaw K, Jantarug K, Slavoff S, Israsena N. A genetic code expansion-derived molecular beacon for the detection of intracellular amyloid-β peptide generation. Angewandte Chemie (International Ed. in English). PMID 33063327 DOI: 10.1002/anie.202010703   
2020 Dhanwani R, Pham J, Premlal ALR, Frazier A, Kumar A, Pero ME, Bartolini F, Dutra JR, Marder KS, Peters B, Sulzer D, Sette A, Lindestam Arlehamn CS. T Cell Responses to Neural Autoantigens Are Similar in Alzheimer's Disease Patients and Age-Matched Healthy Controls. Frontiers in Neuroscience. 14: 874. PMID 32982670 DOI: 10.3389/fnins.2020.00874   
2020 Javed I, Zhang Z, Adamcik J, Andrikopoulos N, Li Y, Otzen DE, Lin S, Mezzenga R, Davis TP, Ding F, Ke PC. Accelerated Amyloid Beta Pathogenesis by Bacterial Amyloid FapC. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 7: 2001299. PMID 32999841 DOI: 10.1002/advs.202001299   
2020 De Mena L, Smith MA, Martin J, Dunton KL, Ceballos-Diaz C, Jansen-West KR, Cruz PE, Dillon KD, Rincon-Limas DE, Golde TE, Moore BD, Levites Y. Aß40 displays amyloidogenic properties in the non-transgenic mouse brain but does not exacerbate Aß42 toxicity in Drosophila. Alzheimer's Research & Therapy. 12: 132. PMID 33069251 DOI: 10.1186/s13195-020-00698-z   
2020 d'Abramo C, D'Adamio L, Giliberto L. Significance of Blood and Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: Sensitivity, Specificity and Potential for Clinical Use. Journal of Personalized Medicine. 10. PMID 32911755 DOI: 10.3390/jpm10030116   
2020 Vaillant-Beuchot L, Mary A, Pardossi-Piquard R, Bourgeois A, Lauritzen I, Eysert F, Kinoshita PF, Cazareth J, Badot C, Fragaki K, Bussiere R, Martin C, Mary R, Bauer C, Pagnotta S, et al. Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains. Acta Neuropathologica. PMID 33079262 DOI: 10.1007/s00401-020-02234-7   
2020 Gao J, Chen X, Ma T, He B, Li P, Zhao Y, Ma Y, Zhuang J, Yin Y. PEG-Ceramide Nanomicelles Induce Autophagy and Degrade Tau Proteins in N2a Cells. International Journal of Nanomedicine. 15: 6779-6789. PMID 32982233 DOI: 10.2147/IJN.S258311   
2020 Feng W, Zhang Y, Wang Z, Xu H, Wu T, Marshall C, Gao J, Xiao M. Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer's disease mouse model with suppression of glymphatic clearance. Alzheimer's Research & Therapy. 12: 125. PMID 33008458 DOI: 10.1186/s13195-020-00688-1   
2020 Perea JR, Bolós M, Avila J. Microglia in Alzheimer's Disease in the Context of Tau Pathology. Biomolecules. 10. PMID 33066368 DOI: 10.3390/biom10101439   
2020 Lingel A, Lin H, Gavriel Y, Weaver E, Polepole P, Lopez V, Lei Y, Petro TM, Solomon B, Zhang C, Zhang L. Amyloid precursor protein is a restriction factor that protects against Zika virus infection in mammalian brains. The Journal of Biological Chemistry. PMID 33028637 DOI: 10.1074/jbc.RA120.015165   
2020 Poon CH, Wang Y, Fung ML, Zhang C, Lim LW. Rodent Models of Amyloid-Beta Feature of Alzheimer's Disease: Development and Potential Treatment Implications. Aging and Disease. 11: 1235-1259. PMID 33014535 DOI: 10.14336/AD.2019.1026   
2020 Al Mamun A, Rahman MM, Zaman S, Munira MS, Uddin MS, Rauf A, Banu N, Ashraf GM. Molecular Insight into the Crosstalk of UPS Components and Alzheimer's Disease. Current Protein & Peptide Science. PMID 32964822 DOI: 10.2174/1389203721666200923153406   
2020 Greco V, Naletova I, Ahmed IMM, Vaccaro S, Messina L, La Mendola D, Bellia F, Sciuto S, Satriano C, Rizzarelli E. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Scientific Reports. 10: 15998. PMID 32994475 DOI: 10.1038/s41598-020-72989-2   
2020 Greco V, Naletova I, Ahmed IMM, Vaccaro S, Messina L, La Mendola D, Bellia F, Sciuto S, Satriano C, Rizzarelli E. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Scientific Reports. 10: 15998. PMID 32994475 DOI: 10.1038/s41598-020-72989-2   
2020 Greco V, Naletova I, Ahmed IMM, Vaccaro S, Messina L, La Mendola D, Bellia F, Sciuto S, Satriano C, Rizzarelli E. Hyaluronan-carnosine conjugates inhibit Aβ aggregation and toxicity. Scientific Reports. 10: 15998. PMID 32994475 DOI: 10.1038/s41598-020-72989-2   
2020 Lauer AA, Mett J, Janitschke D, Thiel A, Stahlmann CP, Bachmann CM, Ritzmann F, Schrul B, Müller UC, Stein R, Riemenschneider M, Grimm HS, Hartmann T, Grimm MOW. Regulatory feedback cycle of the insulin-degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer's disease. Aging Cell. e13264. PMID 33128835 DOI: 10.1111/acel.13264   
2020 da Rocha JF, Bastos L, Domingues SC, Bento AR, Konietzko U, da Cruz E Silva OAB, Vieira SI. APP Binds to the EGFR Ligands HB-EGF and EGF, Acting Synergistically with EGF to Promote ERK Signaling and Neuritogenesis. Molecular Neurobiology. PMID 33009641 DOI: 10.1007/s12035-020-02139-2   
2020 Lieblein T, Zangl R, Martin J, Hoffmann J, Hutchison MJ, Stark T, Stirnal E, Schrader T, Schwalbe H, Morgner N. Structural rearrangement of amyloid-β upon inhibitor binding suppresses formation of Alzheimer disease related oligomers. Elife. 9. PMID 33095161 DOI: 10.7554/eLife.59306   
2020 Alam J. Vitamins: a nutritional intervention to modulate the Alzheimer's disease progression. Nutritional Neuroscience. 1-18. PMID 32998670 DOI: 10.1080/1028415X.2020.1826762   
2020 Siddiqui A, Akhtar MS, Shah Z, Othman I, Kumari Y. Inflammation Drives Alzheimer's Disease: Emphasis on 5-lipoxygenase pathways. Current Neuropharmacology. PMID 32972344 DOI: 10.2174/1570159X18666200924122732   
2020 Zhu W, Wei X, Wang Y, Li J, Peng L, Zhang K, Bai B. Effects of U1 Small Nuclear Ribonucleoprotein Inhibition on the Expression of Genes Involved in Alzheimer's Disease. Acs Omega. 5: 25306-25311. PMID 33043209 DOI: 10.1021/acsomega.0c03568   
2020 Limegrover CS, LeVine H, Izzo NJ, Yurko R, Mozzoni K, Rehak C, Sadlek K, Safferstein H, Catalano SM. Alzheimer's Protection Effect of A673T Mutation May Be Driven by Lower Aβ Oligomer Binding Affinity. Journal of Neurochemistry. PMID 33025581 DOI: 10.1111/jnc.15212   
2020 Yu Y, Grazioli G, Unhelkar MH, Martin RW, Butts CT. Network Hamiltonian models reveal pathways to amyloid fibril formation. Scientific Reports. 10: 15668. PMID 32973286 DOI: 10.1038/s41598-020-72260-8