Jack Timothy Rogers, PhD - Publications

Psychiatry Massachusetts General Hospital and Harvard University, Boston, MA, United States 

86 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Rogers JT, Cahill CM. Iron Responsiveness to Lysosomal Disruption: A Novel Pathway to Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 37781810 DOI: 10.3233/JAD-230953  0.341
2021 Chen XQ, Barrero CA, Vasquez-Del Carpio R, Reddy EP, Fecchio C, Merali S, Deglincerti A, Fang C, Rogers J, Maccecchini ML. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 13. PMID 34959389 DOI: 10.3390/pharmaceutics13122109  0.318
2020 Rogers JT, Cahill CM. Iron-responsive-like elements and neurodegenerative ferroptosis. Learning & Memory (Cold Spring Harbor, N.Y.). 27: 395-413. PMID 32817306 DOI: 10.1101/Lm.052282.120  0.48
2020 Pilozzi A, Yu Z, Carreras I, Cormier K, Hartley D, Rogers J, Dedeoglu A, Huang X. A Preliminary Study of Cu Exposure Effects upon Alzheimer's Amyloid Pathology. Biomolecules. 10. PMID 32155778 DOI: 10.3390/biom10030408  0.323
2020 Mou X, Pilozzi A, Tailor B, Yi J, Cahill C, Rogers J, Huang X. Exposure to CuO Nanoparticles Mediates NFκB Activation and Enhances Amyloid Precursor Protein Expression. Biomedicines. 8. PMID 32120908 DOI: 10.3390/Biomedicines8030045  0.415
2019 Kisby B, Jarrell JT, Agar ME, Cohen DS, Rosin ER, Cahill CM, Rogers JT, Huang X. Alzheimer's Disease and Its Potential Alternative Therapeutics. Journal of Alzheimer's Disease & Parkinsonism. 9. PMID 31588368 DOI: 10.4172/2161-0460.1000477  0.685
2019 Rogers JT, Xia N, Wong A, Bakshi R, Cahill CM. Targeting the Iron-Response Elements of the mRNAs for the Alzheimer's Amyloid Precursor Protein and Ferritin to Treat Acute Lead and Manganese Neurotoxicity. International Journal of Molecular Sciences. 20. PMID 30823541 DOI: 10.3390/Ijms20040994  0.488
2019 Rogers J, Hodgetts K, Aleyadeh R, Huang X, Cahill C. RNA driven improved iron homeostasis in neurons exposed to parkinsonian manganese stress Journal of Psychology & Psychotherapy. DOI: 10.4172/2161-0487-C4-032  0.306
2018 Long JM, Maloney B, Rogers JT, Lahiri DK. Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5'-untranslated region: Implications in Alzheimer's disease. Molecular Psychiatry. PMID 30470799 DOI: 10.1038/S41380-018-0266-3  0.419
2018 Venkataramani V, Doeppner TR, Willkommen D, Cahill CM, Xin Y, Ye G, Liu Y, Southon A, Aron A, Au-Yeung HY, Huang X, Lahiri DK, Wang F, Bush AI, Wulf GG, ... ... Rogers JT, et al. Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin. Journal of Neurochemistry. PMID 30152072 DOI: 10.1111/Jnc.14580  0.427
2018 Lumsden AL, Rogers JT, Majd S, Newman M, Sutherland GT, Verdile G, Lardelli M. Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease. Frontiers in Neuroscience. 12: 533. PMID 30150923 DOI: 10.3389/Fnins.2018.00533  0.435
2018 Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 29340929 DOI: 10.1007/S13311-017-0593-0  0.323
2017 Yin X, Wu Q, Monga J, Xie E, Wang H, Wang S, Zhang H, Wang ZY, Zhou T, Shi Y, Rogers J, Lin H, Min J, Wang F. HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-overload Murine Models. Antioxidants & Redox Signaling. PMID 29113455 DOI: 10.1089/Ars.2017.7161  0.35
2017 Meng T, Cao Q, Lei P, Bush AI, Xiang Q, Su Z, He X, Rogers JT, Chiu IM, Zhang Q, Huang Y. Tat-haFGF14-154 Upregulates ADAM10 to Attenuate the Alzheimer Phenotype of APP/PS1 Mice through the PI3K-CREB-IRE1α/XBP1 Pathway. Molecular Therapy. Nucleic Acids. 7: 439-452. PMID 28624220 DOI: 10.1016/J.Omtn.2017.05.004  0.412
2016 Rogers JT, Venkataramani V, Washburn C, Liu Y, Tummala V, Jiang H, Smith A, Cahill CM. A Role for Amyloid Precursor Protein Translation to Restore Iron Homeostasis and Ameliorate Lead (Pb) Neurotoxicity. Journal of Neurochemistry. PMID 27206843 DOI: 10.1111/Jnc.13671  0.44
2016 Plascencia-Villa G, Ponce A, Collingwood JF, Arellano-Jiménez MJ, Zhu X, Rogers JT, Betancourt I, José-Yacamán M, Perry G. High-resolution analytical imaging and electron holography of magnetite particles in amyloid cores of Alzheimer's disease. Scientific Reports. 6: 24873. PMID 27121137 DOI: 10.1038/Srep24873  0.358
2016 Jiang H, Wang J, Rogers J, Xie J. Brain Iron Metabolism Dysfunction in Parkinson's Disease. Molecular Neurobiology. PMID 27039308 DOI: 10.1007/S12035-016-9879-1  0.399
2016 A. Lu M, Rajanala S, Mikkilineni SV, Cahill CM, Brown R, D. Berry J, Rogers JT. The 5’-Untranslated Region of the C9orf72 mRNA Exhibits a Phylogenetic Alignment to the Cis-Aconitase Iron-Responsive Element; Novel Therapies for Amytrophic Lateral Sclerosis Neuroscience and Medicine. 7: 15-26. DOI: 10.4236/Nm.2016.71003  0.35
2015 Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI. Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3591-7. PMID 25716857 DOI: 10.1523/Jneurosci.3439-14.2015  0.41
2014 Tao Y, Wang Y, Rogers JT, Wang F. Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. Journal of Alzheimer's Disease : Jad. 42: 679-90. PMID 24916541 DOI: 10.3233/Jad-140396  0.454
2014 Bandyopadhyay S, Rogers JT. Alzheimer's disease therapeutics targeted to the control of amyloid precursor protein translation: maintenance of brain iron homeostasis. Biochemical Pharmacology. 88: 486-94. PMID 24513321 DOI: 10.1016/J.Bcp.2014.01.032  0.519
2013 Bandyopadhyay S, Cahill C, Balleidier A, Huang C, Lahiri DK, Huang X, Rogers JT. Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease. Plos One. 8: e65978. PMID 23935819 DOI: 10.1371/Journal.Pone.0065978  0.493
2013 Lahiri DK, Maloney B, Rogers JT, Ge YW. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE). Bmc Genomics. 14: 68. PMID 23368879 DOI: 10.1186/1471-2164-14-68  0.471
2013 Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-Synuclein synthesis, interleukin-1β release, and cholinergic action. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 12: 117-28. PMID 23360256 DOI: 10.2174/1871523011312020003  0.412
2013 Hahl P, Davis T, Washburn C, Rogers JT, Smith A. Mechanisms of neuroprotection by hemopexin: modeling the control of heme and iron homeostasis in brain neurons in inflammatory states. Journal of Neurochemistry. 125: 89-101. PMID 23350672 DOI: 10.1111/Jnc.12165  0.365
2013 Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI. Amine oxidase activity of β-amyloid precursor protein modulates systemic and local catecholamine levels. Molecular Psychiatry. 18: 245-54. PMID 22212595 DOI: 10.1038/Mp.2011.168  0.358
2013 Rogers J, Spoonamore J. Novel untranslated region-directed blockers of amyloid precursor protein translation for late Down syndrome and Alzheimer's disease therapy Alzheimers & Dementia. 9: 855. DOI: 10.1016/J.Jalz.2013.08.170  0.411
2012 Mikkilineni S, Cantuti-Castelvetri I, Cahill CM, Balliedier A, Greig NH, Rogers JT. The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression. Parkinson's Disease. 2012: 142372. PMID 22693681 DOI: 10.1155/2012/142372  0.36
2012 Olivares D, Deshpande VK, Shi Y, Lahiri DK, Greig NH, Rogers JT, Huang X. N-methyl D-aspartate (NMDA) receptor antagonists and memantine treatment for Alzheimer's disease, vascular dementia and Parkinson's disease. Current Alzheimer Research. 9: 746-58. PMID 21875407 DOI: 10.2174/156720512801322564  0.373
2012 Rogers J, Kolar J, Washburn C, Cahill C, Huang X. Therapeutic action of translation blockers on expression of the amyloid precursor protein as a central ferroxidase Alzheimers & Dementia. 8: 714. DOI: 10.1016/J.Jalz.2012.05.1930  0.382
2011 Rogers JT, Mikkilineni S, Cantuti-Castelvetri I, Smith DH, Huang X, Bandyopadhyay S, Cahill CM, Maccecchini ML, Lahiri DK, Greig NH. The alpha-synuclein 5'untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen. Journal of Neural Transmission (Vienna, Austria : 1996). 118: 493-507. PMID 21221670 DOI: 10.1007/S00702-010-0513-5  0.369
2011 Duce J, Lei P, Tsatsanis A, Ayton S, Lam L, Adlard P, Ciccotosto G, Masters C, Cappai R, Barnham K, Rogers J, Finkelstein D, Bush A. The relationship between beta-amyloid protein precursor and tau in Alzheimer's disease-related iron disruption Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1422  0.469
2010 Bandyopadhyay S, Huang X, Lahiri DK, Rogers JT. Novel drug targets based on metallobiology of Alzheimer's disease. Expert Opinion On Therapeutic Targets. 14: 1177-97. PMID 20942746 DOI: 10.1517/14728222.2010.525352  0.468
2010 Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, ... ... Rogers JT, et al. Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell. 142: 857-67. PMID 20817278 DOI: 10.1016/J.Cell.2010.08.014  0.482
2010 Cho HH, Cahill CM, Vanderburg CR, Scherzer CR, Wang B, Huang X, Rogers JT. Selective translational control of the Alzheimer amyloid precursor protein transcript by iron regulatory protein-1. The Journal of Biological Chemistry. 285: 31217-32. PMID 20558735 DOI: 10.1074/Jbc.M110.149161  0.414
2010 Maloney B, Ge YW, Petersen RC, Hardy J, Rogers JT, Pérez-Tur J, Lahiri DK. Functional characterization of three single-nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA-protein interactions. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 185-201. PMID 19504470 DOI: 10.1002/Ajmg.B.30973  0.357
2010 Goldstein LE, Moir RD, Mocofanescu A, Fu L, Lu S, Burton MA, Xu W, Ericsson M, Rogers J, Chadwick O, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, et al. P4-011: In vivo Detection of Early Alzheimer's Disease-Linked Aβ Peptide Accumulation in the Lens by Non-Invasive Quasi-Elastic Light Scattering Alzheimer's & Dementia. 6: e23-e23. DOI: 10.1016/J.Jalz.2010.08.071  0.353
2009 Olivares D, Huang X, Branden L, Greig NH, Rogers JT. Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element. International Journal of Molecular Sciences. 10: 1226-60. PMID 19399246 DOI: 10.3390/Ijms10031226  0.396
2009 Kong W, Mou X, Liu Q, Chen Z, Vanderburg CR, Rogers JT, Huang X. Independent component analysis of Alzheimer's DNA microarray gene expression data. Molecular Neurodegeneration. 4: 5. PMID 19173745 DOI: 10.1186/1750-1326-4-5  0.347
2009 Cahill CM, Lahiri DK, Huang X, Rogers JT. Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochimica Et Biophysica Acta. 1790: 615-28. PMID 19166904 DOI: 10.1016/J.Bbagen.2008.12.001  0.496
2009 Lahiri DK, Maloney B, Ray B, Rogers JT, Zawia N. S4-03-03: The “LEARn” (Latent Early-life Associated Regulation) model may explain the etiology of sporadic cases of Alzheimer's disease Alzheimer's & Dementia. 5: P146-P146. DOI: 10.1016/J.Jalz.2009.05.501  0.349
2009 Rogers JT, Huang X, Goldstein LE, Moncaster JA, Lahiri DK, Cahill CM, Cho H, Fischer M, Glicksman MA, Cuny GD, Rogers MS, Greig NH, Smith DH, Branden LJ. Specific APP translation blockers as a therapeutic intervention for Alzheimer's disease Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.05.470  0.397
2008 Rogers JT, Bush AI, Cho HH, Smith DH, Thomson AM, Friedlich AL, Lahiri DK, Leedman PJ, Huang X, Cahill CM. Iron and the translation of the amyloid precursor protein (APP) and ferritin mRNAs: riboregulation against neural oxidative damage in Alzheimer's disease. Biochemical Society Transactions. 36: 1282-7. PMID 19021541 DOI: 10.1042/Bst0361282  0.489
2008 Patel N, Hoang D, Miller N, Ansaloni S, Huang Q, Rogers JT, Lee JC, Saunders AJ. MicroRNAs can regulate human APP levels. Molecular Neurodegeneration. 3: 10. PMID 18684319 DOI: 10.1186/1750-1326-3-10  0.356
2008 Moncaster JA, Moir RD, Mocofanescu AG, Burton MA, Ghosh J, Ericsson M, Rogers JT, Klunk WE, Mathis CA, Sadowski M, Wisniewski T, Clark JI, Tanzi RE, Goldstein LE. P1-379: In vivo detection of Alzheimer's disease–linked Aβ peptide accumulation in the lens Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.961  0.355
2008 Duce JA, Rogers JT, Tsatsanis A, Moir RD, Robb E, Leong SL, Harding SM, Venti A, Masters C, Cappai R, Tanzi RE, Bush AI. P3-325: Alzheimer's disease β-amyloid protein precursor is ferroxidase II, a ceruloplasmin-like iron detoxification enzyme Alzheimer's & Dementia. 4: T617-T617. DOI: 10.1016/J.Jalz.2008.05.1894  0.425
2007 Bandyopadhyay S, Goldstein LE, Lahiri DK, Rogers JT. Role of the APP non-amyloidogenic signaling pathway and targeting alpha-secretase as an alternative drug target for treatment of Alzheimer's disease. Current Medicinal Chemistry. 14: 2848-64. PMID 18045131 DOI: 10.2174/092986707782360060  0.347
2007 Friedlich AL, Tanzi RE, Rogers JT. The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Molecular Psychiatry. 12: 222-3. PMID 17325711 DOI: 10.1038/Sj.Mp.4001937  0.364
2007 Moncaster J, Moir RD, Fu L, Mocofanescu A, Lu S, Xu W, Chadwick O, Rogers JT, Sadowski M, Wisniewski T, Klunk WE, Mathis CA, Clark JI, Tanzi RE, Goldstein LE. O2-03-05: Early detection of Alzheimer's disease-linked aβ peptide accumulation in the lens by non-invasive quasi-elastic light scattering Alzheimer's & Dementia. 3: S190-S190. DOI: 10.1016/J.Jalz.2007.04.030  0.347
2006 Bandyopadhyay S, Huang X, Cho H, Greig NH, Youdim MB, Rogers JT. Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator. Journal of Neural Transmission. Supplementum. 237-47. PMID 17447434 DOI: 10.1007/978-3-211-33328-0_25  0.417
2006 Lahiri DK, Ge YW, Rogers JT, Sambamurti K, Greig NH, Maloney B. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Current Alzheimer Research. 3: 475-83. PMID 17168646 DOI: 10.2174/156720506779025224  0.402
2006 Bandyopadhyay S, Ni J, Ruggiero A, Walshe K, Rogers MS, Chattopadhyay N, Glicksman MA, Rogers JT. A high-throughput drug screen targeted to the 5'untranslated region of Alzheimer amyloid precursor protein mRNA. Journal of Biomolecular Screening. 11: 469-80. PMID 16928984 DOI: 10.1177/1087057106287271  0.44
2006 Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Current Alzheimer Research. 3: 221-7. PMID 16842099 DOI: 10.2174/156720506777632835  0.426
2006 Liu G, Huang W, Moir RD, Vanderburg CR, Lai B, Peng Z, Tanzi RE, Rogers JT, Huang X. Metal exposure and Alzheimer's pathogenesis. Journal of Structural Biology. 155: 45-51. PMID 16503166 DOI: 10.1016/J.Jsb.2005.12.011  0.447
2005 Tucker S, Ahl M, Bush A, Westaway D, Huang X, Rogers JT. Pilot study of the reducing effect on amyloidosis in vivo by three FDA pre-approved drugs via the Alzheimer's APP 5' untranslated region. Current Alzheimer Research. 2: 249-54. PMID 15974925 DOI: 10.2174/1567205053585855  0.412
2005 Thomson AM, Cahill CM, Cho HH, Kassachau KD, Epis MR, Bridges KR, Leedman PJ, Rogers JT. The acute box cis-element in human heavy ferritin mRNA 5'-untranslated region is a unique translation enhancer that binds poly(C)-binding proteins. The Journal of Biological Chemistry. 280: 30032-45. PMID 15967798 DOI: 10.1074/Jbc.M502951200  0.369
2005 Rogers JT, Bandyopadhyay S, Tucker S, Huang X, Gullans S. Alzheimer’s disease drug discovery targeted to the APP mRNA 5′ untranslated region, paroxetine proof-of-concept for a validated target Alzheimers & Dementia. 1. DOI: 10.1016/J.Jalz.2005.06.257  0.343
2004 Greig NH, Mattson MP, Perry T, Chan SL, Giordano T, Sambamurti K, Rogers JT, Ovadia H, Lahiri DK. New therapeutic strategies and drug candidates for neurodegenerative diseases: p53 and TNF-alpha inhibitors, and GLP-1 receptor agonists. Annals of the New York Academy of Sciences. 1035: 290-315. PMID 15681814 DOI: 10.1196/Annals.1332.018  0.396
2004 Lahiri DK, Chen D, Lahiri P, Rogers JT, Greig NH, Bondy S. Melatonin, metals, and gene expression: implications in aging and neurodegenerative disorders. Annals of the New York Academy of Sciences. 1035: 216-30. PMID 15681810 DOI: 10.1196/Annals.1332.014  0.37
2004 Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT. The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Annals of the New York Academy of Sciences. 1035: 34-48. PMID 15681799 DOI: 10.1196/Annals.1332.003  0.482
2004 Dedeoglu A, Cormier K, Payton S, Tseitlin KA, Kremsky JN, Lai L, Li X, Moir RD, Tanzi RE, Bush AI, Kowall NW, Rogers JT, Huang X. Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis. Experimental Gerontology. 39: 1641-9. PMID 15582280 DOI: 10.1016/J.Exger.2004.08.016  0.439
2004 Lahiri DK, Rogers JT, Greig NH, Sambamurti K. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Current Pharmaceutical Design. 10: 3111-9. PMID 15544501 DOI: 10.2174/1381612043383331  0.435
2004 Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. Journal of Molecular Neuroscience : Mn. 24: 129-36. PMID 15314261 DOI: 10.1385/Jmn:24:1:129  0.462
2004 Rogers JT, Lahiri DK. Metal and inflammatory targets for Alzheimer's disease. Current Drug Targets. 5: 535-51. PMID 15270200 DOI: 10.2174/1389450043345272  0.502
2004 Huang X, Moir RD, Tanzi RE, Bush AI, Rogers JT. Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Annals of the New York Academy of Sciences. 1012: 153-63. PMID 15105262 DOI: 10.1196/Annals.1306.012  0.454
2004 Rogers JT, Payton S, Greig NH, Jensen R, Cuny G, Lahiri DK, Morse LJ, Tanzi RE, Westaway D, Bush A, Gullans S, Sarang S, Huang X. P4-402 Alzheimer's disease drug discovery targeted to the APP MRNA 5′ untranslated region, a validated target Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81959-6  0.391
2004 Rogers JT, Morse LJ, Lombardi M, Devaney P, Jensen R. P4-245 Metallothionein 3 gene expression is up-regulated by intracellular iron chelation, the role of a putative iron-responsive element in the 3′ untranslated region Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81803-7  0.354
2004 Greig NH, Utsuki T, Wang Y, Ingram DK, Mamczar J, Rogers J, Yun Q, Holloway HW, Perry TA, Sambamurti K, Scali C, Pepeu G, Lahiri DK. P1-414 Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers amyloid-beta peptide in rodents: a new treatment strategy for Alzheimer's disease Neurobiology of Aging. 25: S216. DOI: 10.1016/S0197-4580(04)80726-7  0.366
2003 Payton S, Cahill CM, Randall JD, Gullans SR, Rogers JT. Drug discovery targeted to the Alzheimer's APP mRNA 5'-untranslated region: the action of paroxetine and dimercaptopropanol. Journal of Molecular Neuroscience : Mn. 20: 267-75. PMID 14501007 DOI: 10.1385/Jmn:20:3:267  0.412
2003 Lahiri DK, Chen D, Vivien D, Ge YW, Greig NH, Rogers JT. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 5: 81-90. PMID 12719626 DOI: 10.3233/Jad-2003-5203  0.408
2002 Rogers JT, Randall JD, Eder PS, Huang X, Bush AI, Tanzi RE, Venti A, Payton SM, Giordano T, Nagano S, Cahill CM, Moir R, Lahiri DK, Greig N, Sarang SS, et al. Alzheimer's disease drug discovery targeted to the APP mRNA 5'untranslated region. Journal of Molecular Neuroscience : Mn. 19: 77-82. PMID 12212798 DOI: 10.1007/S12031-002-0014-6  0.431
2002 Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, et al. An iron-responsive element type II in the 5'-untranslated region of the Alzheimer's amyloid precursor protein transcript. The Journal of Biological Chemistry. 277: 45518-28. PMID 12198135 DOI: 10.1074/Jbc.M207435200  0.461
2001 Gunshin H, Allerson CR, Polycarpou-Schwarz M, Rofts A, Rogers JT, Kishi F, Hentze MW, Rouault TA, Andrews NC, Hediger MA. Iron-dependent regulation of the divalent metal ion transporter. Febs Letters. 509: 309-16. PMID 11741608 DOI: 10.1016/S0014-5793(01)03189-1  0.374
2001 Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH. Phenserine regulates translation of beta -amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proceedings of the National Academy of Sciences of the United States of America. 98: 7605-10. PMID 11404470 DOI: 10.1073/Pnas.131152998  0.454
2000 Bush AI, Atwood CS, Goldstein LE, Huang X, Rogers J. Could Abeta and AbetaPP be Antioxidants? Journal of Alzheimer's Disease : Jad. 2: 83-84. PMID 12214093 DOI: 10.3233/Jad-2000-2203  0.314
2000 Thomson AM, Rogers JT, Leedman PJ. Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. The Journal of Biological Chemistry. 275: 31609-15. PMID 10889193 DOI: 10.1074/Jbc.M002354200  0.336
2000 Rogers JT, Moir RD, Huang X, Venti A, Sarhan N, Nostrand WEV, Tanzi R. Intrinsic ferroxidase activity in the Alzheimer's amyloid precursor protein Neurobiology of Aging. 21: 261. DOI: 10.1016/S0197-4580(00)83126-7  0.42
1999 Thomson AM, Rogers JT, Leedman PJ. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation. The International Journal of Biochemistry & Cell Biology. 31: 1139-52. PMID 10582343 DOI: 10.1016/S1357-2725(99)00080-1  0.385
1999 Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, Potter H, Nilsson LN. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5'-untranslated region sequences. The Journal of Biological Chemistry. 274: 6421-31. PMID 10037734 DOI: 10.1074/Jbc.274.10.6421  0.425
1999 Toth I, Yuan L, Rogers JT, Boyce H, Bridges KR. Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. The Journal of Biological Chemistry. 274: 4467-73. PMID 9933651 DOI: 10.1074/Jbc.274.7.4467  0.376
1996 Leedman PJ, Stein AR, Chin WW, Rogers JT. Thyroid hormone modulates the interaction between iron regulatory proteins and the ferritin mRNA iron-responsive element. The Journal of Biological Chemistry. 271: 12017-23. PMID 8662626 DOI: 10.1074/Jbc.271.20.12017  0.345
1995 Toth I, Rogers JT, McPhee JA, Elliott SM, Abramson SL, Bridges KR. Ascorbic acid enhances iron-induced ferritin translation in human leukemia and hepatoma cells. The Journal of Biological Chemistry. 270: 2846-52. PMID 7852359 DOI: 10.1074/Jbc.270.6.2846  0.386
1994 Rogers JT, Andriotakis JL, Lacroix L, Durmowicz GP, Kasschau KD, Bridges KR. Translational enhancement of H-ferritin mRNA by interleukin-1 beta acts through 5' leader sequences distinct from the iron responsive element. Nucleic Acids Research. 22: 2678-86. PMID 8041631 DOI: 10.1093/Nar/22.13.2678  0.325
1994 Rogers J, Lacroix L, Durmowitz G, Kasschau K, Andriotakis J, Bridges KR. The role of cytokines in the regulation of ferritin expression. Advances in Experimental Medicine and Biology. 356: 127-132. PMID 7534028 DOI: 10.1007/978-1-4615-2554-7_14  0.332
1993 Steel DM, Rogers JT, DeBeer MC, DeBeer FC, Whitehead AS. Biosynthesis of human acute-phase serum amyloid A protein (A-SAA) in vitro: the roles of mRNA accumulation, poly(A) tail shortening and translational efficiency. The Biochemical Journal. 291: 701-7. PMID 8387777 DOI: 10.1042/Bj2910701  0.312
1987 Rogers J, Munro H. Translation of ferritin light and heavy subunit mRNAs is regulated by intracellular chelatable iron levels in rat hepatoma cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 2277-81. PMID 3470792 DOI: 10.1073/Pnas.84.8.2277  0.39
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