John H. Krystal, M.D. - Publications

Affiliations: 
Psychiatry Yale University, New Haven, CT 

333 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Averill LA, Jiang L, Purohit P, Coppoli A, Averill CL, Roscoe J, Kelmendi B, De Feyter HM, de Graaf RA, Gueorguieva R, Sanacora G, Krystal JH, Rothman DL, Mason GF, Abdallah CG. Prefrontal Glutamate Neurotransmission in PTSD: A Novel Approach to Estimate Synaptic Strength in Vivo in Humans. Chronic Stress (Thousand Oaks, Calif.). 6: 24705470221092734. PMID 35434443 DOI: 10.1177/24705470221092734  0.482
2022 Cho YT, Moujaes F, Schleifer CH, Starc M, Ji JL, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal JH, Murray JD, Repovs G, Anticevic A. Reward and loss incentives improve spatial working memory by shaping trial-by-trial posterior frontoparietal signals. Neuroimage. 254: 119139. PMID 35346841 DOI: 10.1016/j.neuroimage.2022.119139  0.49
2022 Holmes SE, Finnema SJ, Naganawa M, DellaGioia N, Holden D, Fowles K, Davis M, Ropchan J, Emory P, Ye Y, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, ... ... Krystal JH, et al. Imaging the effect of ketamine on synaptic density (SV2A) in the living brain. Molecular Psychiatry. PMID 35165397 DOI: 10.1038/s41380-022-01465-2  0.539
2022 Averill LA, Averill CL, Gueorguieva R, Fouda S, Sherif M, Ahn KH, Ranganathan M, D'Souza DC, Southwick SM, Sanacora G, Duman RS, Krystal JH, Abdallah CG. mTORC1 inhibitor effects on rapid ketamine-induced reductions in suicidal ideation in patients with treatment-resistant depression. Journal of Affective Disorders. PMID 35101523 DOI: 10.1016/j.jad.2022.01.104  0.519
2021 Lam NH, Borduqui T, Hallak J, Roque A, Anticevic A, Krystal JH, Wang XJ, Murray JD. Effects of Altered Excitation-Inhibition Balance on Decision Making in a Cortical Circuit Model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34887320 DOI: 10.1523/JNEUROSCI.1371-20.2021  0.505
2021 Abi-Dargham A, Javitch JA, Slifstein M, Anticevic A, Calkins ME, Cho YT, Fonteneau C, Gil R, Girgis R, Gur RE, Gur RC, Grinband J, Kantrowitz J, Kohler C, Krystal J, et al. Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia. Schizophrenia Bulletin. PMID 34423843 DOI: 10.1093/schbul/sbab095  0.526
2021 Burt JB, Preller KH, Demirtas M, Ji JL, Krystal JH, Vollenweider FX, Anticevic A, Murray JD. Transcriptomics-informed large-scale cortical model captures topography of pharmacological neuroimaging effects of LSD. Elife. 10. PMID 34313217 DOI: 10.7554/eLife.69320  0.527
2021 Haeny AM, Gueorguieva R, Jackson A, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS. Individual differences in the associations between risk factors for alcohol use disorder and alcohol use-related outcomes. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. PMID 34110841 DOI: 10.1037/adb0000733  0.498
2021 DeMartini KS, Gueorguieva R, Pearlson G, Krishnan-Sarin S, Anticevic A, Ji LJ, Krystal JH, O'Malley SS. Mapping Data-Driven Individualized Neurobehavioral Phenotypes in Heavy Alcohol Drinkers. Alcoholism, Clinical and Experimental Research. PMID 33605439 DOI: 10.1111/acer.14580  0.515
2020 Hillmer AT, Angarita GA, Esterlis I, Anderson JM, Nabulsi N, Lim K, Ropchan J, Carson RE, Krystal JH, Malley SSO, Cosgrove KP. Longitudinal imaging of metabotropic glutamate 5 receptors during early and extended alcohol abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32919411 DOI: 10.1038/S41386-020-00856-9  0.309
2020 Kantrowitz JT, Grinband J, Goff DC, Lahti AC, Marder SR, Kegeles LS, Girgis RR, Sobeih T, Wall MM, Choo TH, Green MF, Yang YS, Lee J, Horga G, Krystal JH, et al. Proof of mechanism and target engagement of glutamatergic drugs for the treatment of schizophrenia: RCTs of pomaglumetad and TS-134 on ketamine-induced psychotic symptoms and pharmacoBOLD in healthy volunteers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32403118 DOI: 10.1038/S41386-020-0706-Z  0.318
2020 Krystal JH, Charney DS, Duman RS. A New Rapid-Acting Antidepressant. Cell. 181: 7. PMID 32243798 DOI: 10.1016/J.Cell.2020.02.033  0.453
2020 Preller KH, Duerler P, Burt JB, Ji JL, Adkinson B, Stämpfli P, Seifritz E, Repovš G, Krystal JH, Murray JD, Anticevic A, Vollenweider FX. Psilocybin Induces Time-Dependent Changes in Global Functional Connectivity. Biological Psychiatry. PMID 32111343 DOI: 10.1016/J.Biopsych.2019.12.027  0.545
2020 Abdallah CG, Averill LA, Gueorguieva R, Goktas S, Purohit P, Ranganathan M, Sherif M, Ahn KH, D'Souza DC, Formica R, Southwick SM, Duman RS, Sanacora G, Krystal JH. Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32092760 DOI: 10.1038/S41386-020-0644-9  0.567
2020 Krystal JH, Nestler EJ, Picciotto MR. Ronald S. Duman, Ph.D. (1954-2020). Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32076104 DOI: 10.1038/S41386-020-0642-Y  0.374
2020 Nestler EJ, Krystal JH. Ronald S. Duman (1954–2020) Neuron. 105: 769-770. DOI: 10.1016/J.Neuron.2020.02.018  0.378
2019 Suzuki S, Mell MM, O'Malley SS, Krystal JH, Anticevic A, Kober H. Regulation of Craving and Negative Emotion in Alcohol Use Disorder. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 31892465 DOI: 10.1016/J.Bpsc.2019.10.005  0.565
2019 Dennis EL, Disner SG, Fani N, Salminen LE, Logue M, Clarke EK, Haswell CC, Averill CL, Baugh LA, Bomyea J, Bruce SE, Cha J, Choi K, Davenport ND, Densmore M, ... ... Krystal J, et al. Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium. Molecular Psychiatry. PMID 31857689 DOI: 10.1038/S41380-019-0631-X  0.322
2019 Haeny AM, Gueorguieva R, Morean ME, Krishnan-Sarin S, DeMartini KS, Pearlson GD, Anticevic A, Krystal JH, O'Malley SS. The Association of Impulsivity and Family History of Alcohol Use Disorder on Alcohol Use and Consequences. Alcoholism, Clinical and Experimental Research. PMID 31693193 DOI: 10.1111/Acer.14230  0.546
2019 Chen MH, Cheng CM, Gueorguieva R, Lin WC, Li CT, Hong CJ, Tu PC, Bai YM, Tsai SJ, Krystal JH, Su TP. Maintenance of antidepressant and antisuicidal effects by D-cycloserine among patients with treatment-resistant depression who responded to low-dose ketamine infusion: a double-blind randomized placebo-control study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31421635 DOI: 10.1038/S41386-019-0480-Y  0.319
2019 Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, et al. Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex (New York, N.Y. : 1991). PMID 31157363 DOI: 10.1093/Cercor/Bhy306  0.695
2019 Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, López-Roca AL, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, ... ... Krystal JH, et al. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. Contemporary Clinical Trials. PMID 30999057 DOI: 10.1016/J.Cct.2019.04.009  0.305
2019 Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications. 10: 1529. PMID 30948709 DOI: 10.1038/S41467-019-09562-7  0.567
2019 Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron. 102: 75-90. PMID 30946828 DOI: 10.1016/J.Neuron.2019.03.013  0.604
2019 Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, ... ... Krystal JH, et al. A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. Neuroimage. Clinical. 22: 101739. PMID 30852397 DOI: 10.1016/J.Nicl.2019.101739  0.369
2019 Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron. 101: 774-778. PMID 30844397 DOI: 10.1016/J.Neuron.2019.02.005  0.639
2019 Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, ... ... Krystal JH, et al. Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. Schizophrenia Research. PMID 30685394 DOI: 10.1016/J.Schres.2018.12.041  0.7
2019 Burt J, Preller K, Demirtas M, Ji JL, Krystal J, Vollenweider F, Anticevic A, Murray J. S175. Large-Scale Model of Human Cortex Captures LSD-Induced Functional Alterations via HTR2A-Mediated Neural Gain Modulation Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.926  0.549
2019 Moujaes F, Preller K, Vollenweider F, Schleifer C, Ji JL, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Santamauro N, Morgan P, Savic A, Cho Y, et al. S159. NMDA Receptor Antagonism Effects on Delayed Spatial Working Memory and Distraction in Comparison With Schizophrenia Biological Psychiatry. 85: S358. DOI: 10.1016/J.Biopsych.2019.03.910  0.571
2019 Moujaes F, Schleifer C, Ji L, Adkinson B, Kolobaric A, Flynn M, Fineberg S, Krystal J, Repovs G, Cho Y, Santamauro N, Morgan P, Savic A, Murray J, Anticevic A. F195. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic Versus Hippocampal Brain-Wide Functional Connectivity Biological Psychiatry. 85: S289. DOI: 10.1016/J.Biopsych.2019.03.732  0.541
2019 Cho Y, Schleifer C, Moujaes F, Starc M, Ji JL, Santamauro N, Adkinson B, Kolobaric A, Flynn M, Krystal J, Murray J, Repovs G, Anticevic A. T193. Monetary Incentives Shape Behavioral and Neural Precision of Spatial Working Memory Biological Psychiatry. 85: S204-S205. DOI: 10.1016/J.Biopsych.2019.03.516  0.521
2019 Kolobaric A, Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole M, Savic A, Yang G, Repovs G, Murray J, Wang X, Huang X, Lui S, ... Krystal J, et al. T174. Examining the Neurobiological Progression of Early Course Schizophrenia Biological Psychiatry. 85: S196-S197. DOI: 10.1016/J.Biopsych.2019.03.497  0.67
2019 Holmes S, Scheinost D, Finnema S, Naganawa M, Davis M, DellaGioia N, Nabulsi N, Matuskey D, Angarita G, Pietrzak R, Duman R, Sanacora G, Krystal J, Carson R, Esterlis I. 142. Synaptic Density Alterations are Associated With Depression Severity and Network Alterations Biological Psychiatry. 85. DOI: 10.1016/J.Biopsych.2019.03.156  0.536
2018 Chekroud AM, Loho H, Paulus M, Krystal JH. PTSD and the War of Words. Chronic Stress (Thousand Oaks, Calif.). 2: 2470547018767387. PMID 32440582 DOI: 10.1177/2470547018767387  0.663
2018 Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder. Molecular Neuropsychiatry. 4: 75-82. PMID 30397595 DOI: 10.1159/000490464  0.618
2018 Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Topology of brain functional connectivity networks in posttraumatic stress disorder. Data in Brief. 20: 1658-1675. PMID 30364328 DOI: 10.1016/J.Dib.2018.08.198  0.641
2018 Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. Elife. 7. PMID 30355445 DOI: 10.7554/Elife.35082  0.566
2018 Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Physical activity and mental health - Author's reply. The Lancet. Psychiatry. PMID 30245184 DOI: 10.1016/S2215-0366(18)30354-7  0.647
2018 Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. Annual Review of Pharmacology and Toxicology. PMID 30216745 DOI: 10.1146/Annurev-Pharmtox-010818-021701  0.312
2018 Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet. Psychiatry. PMID 30099000 DOI: 10.1016/S2215-0366(18)30227-X  0.651
2018 Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29977074 DOI: 10.1038/S41386-018-0136-3  0.577
2018 Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH. Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study. Psychiatric Services (Washington, D.C.). appips201800094. PMID 29962307 DOI: 10.1176/Appi.Ps.201800094  0.679
2018 Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics. PMID 29803629 DOI: 10.1016/J.Pharmthera.2018.05.010  0.573
2018 Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach. Neuroimage. PMID 29730491 DOI: 10.1016/J.Neuroimage.2018.05.005  0.659
2018 D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry. PMID 29499855 DOI: 10.1016/J.Biopsych.2017.12.019  0.303
2018 Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Author response: Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Elife. DOI: 10.7554/Elife.35082.028  0.551
2018 Cho Y, Schleifer C, Moujaes F, Starc M, Ji JL, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. S232. Effects of Incentive Presentation on Spatial Working Memory Performance Biological Psychiatry. 83: S438. DOI: 10.1016/J.Biopsych.2018.02.1124  0.52
2017 Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 29520395  0.639
2017 Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, ... ... Krystal JH, et al. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry. PMID 29217296 DOI: 10.1016/J.Biopsych.2017.09.006  0.307
2017 Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, et al. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. Jama Psychiatry. PMID 29167877 DOI: 10.1001/Jamapsychiatry.2017.3572  0.307
2017 Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2: 566-574. PMID 29034354 DOI: 10.1016/J.Bpsc.2017.04.006  0.335
2017 Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR. Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS? Schizophrenia Research. PMID 28969932 DOI: 10.1016/J.Schres.2017.09.020  0.305
2017 Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports. 19: 74. PMID 28844076 DOI: 10.1007/S11920-017-0829-Z  0.558
2017 Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 28825050  0.626
2017 Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, ... ... Krystal JH, et al. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. Jama Psychiatry. PMID 28813562 DOI: 10.1001/Jamapsychiatry.2017.2269  0.31
2017 Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716937 DOI: 10.1073/Pnas.1701749114  0.332
2017 Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH. A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans. Journal of Affective Disorders. 223: 17-19. PMID 28715723 DOI: 10.1016/J.Jad.2017.07.006  0.311
2017 Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry. 81: 874-885. PMID 28434616 DOI: 10.1016/J.Biopsych.2017.01.004  0.698
2017 Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry. 81: 848-861. PMID 28434615 DOI: 10.1016/J.Biopsych.2017.03.005  0.698
2017 Esterlis I, DellaGioia N, Pietrzak RH, Matuskey D, Nabulsi N, Abdallah CG, Yang J, Pittenger C, Sanacora G, Krystal JH, Parsey RV, Carson RE, DeLorenzo C. Ketamine-induced reduction in mGluR5 availability is associated with an antidepressant response: an [(11)C]ABP688 and PET imaging study in depression. Molecular Psychiatry. PMID 28397841 DOI: 10.1038/Mp.2017.58  0.574
2017 Chekroud AM, Loho H, Krystal JH. Mental illness and mental health. The Lancet. Psychiatry. 4: 276-277. PMID 28347431 DOI: 10.1016/S2215-0366(17)30088-3  0.649
2017 Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A. Computational Psychiatry and the Challenge of Schizophrenia. Schizophrenia Bulletin. PMID 28338845 DOI: 10.1093/Schbul/Sbx025  0.782
2017 Wrocklage KM, Averill LA, Cobb Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 28279623 DOI: 10.1016/J.Euroneuro.2017.02.010  0.304
2017 Abdallah CG, Wrocklage KM, Averill CL, Akiki T, Schweinsburg B, Roy A, Martini B, Southwick SM, Krystal JH, Scott JC. Anterior hippocampal dysconnectivity in posttraumatic stress disorder: a dimensional and multimodal approach. Translational Psychiatry. 7: e1045. PMID 28244983 DOI: 10.1038/Tp.2017.12  0.349
2017 Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach. Jama Psychiatry. PMID 28241180 DOI: 10.1001/Jamapsychiatry.2017.0025  0.685
2017 Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet. Psychiatry. PMID 28189575 DOI: 10.1016/S2215-0366(17)30038-X  0.693
2017 Anticevic A, Schleifer C, Srihari V, Krystal J, Murray J, Repovs G, Xu G, Ji L, Cho Y, Santamauro N, Foss-Feig J, Yang G, Morgan P, Savic A. 423. NMDAR Antagonism via Ketamine Differentially Modulates Thalamic versus Hippocampal Functional Connectivity Biological Psychiatry. 81: S172-S173. DOI: 10.1016/J.Biopsych.2017.02.907  0.663
2017 Cho Y, Schleifer C, Starc M, Lisa Ji J, Santamauro N, Adkinson B, Lituchy M, Krystal J, Murray J, Repovs G, Anticevic A. 961. Incentives to Perform: The Effects of Reward on Working Memory Biological Psychiatry. 81: S389. DOI: 10.1016/J.Biopsych.2017.02.687  0.522
2017 Preller K, Schleifer C, Stämpfli P, Krystal J, Vollenweider F, Anticevic A. 951. Changes in Resting-State Global Brain Connectivity in LSD-Induced Altered States of Consciousness are Attributable to the 5-HT2A Receptor Biological Psychiatry. 81: S385. DOI: 10.1016/J.Biopsych.2017.02.677  0.544
2016 Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 1: 300-301. PMID 29560862 DOI: 10.1016/J.Bpsc.2016.03.007  0.397
2016 Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate Dysregulation and Glutamatergic Therapeutics for PTSD: Evidence from Human Studies. Neuroscience Letters. PMID 27916636 DOI: 10.1016/J.Neulet.2016.11.064  0.338
2016 Kelmendi B, Adams TG, Yarnell S, Southwick S, Abdallah CG, Krystal JH. PTSD: from neurobiology to pharmacological treatments. European Journal of Psychotraumatology. 7: 31858. PMID 27837583 DOI: 10.3402/Ejpt.V7.31858  0.318
2016 Khlestova E, Johnson JW, Krystal JH, Lisman J. The Role of GluN2C-Containing NMDA Receptors in Ketamine's Psychotogenic Action and in Schizophrenia Models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 11151-11157. PMID 27807157 DOI: 10.1523/Jneurosci.1203-16.2016  0.34
2016 Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research. PMID 27745755 DOI: 10.1016/J.Schres.2016.10.011  0.591
2016 Yang GJ, Murray JD, Glasser M, Pearlson GD, Krystal JH, Schleifer C, Repovs G, Anticevic A. Altered Global Signal Topography in Schizophrenia. Cerebral Cortex (New York, N.Y. : 1991). PMID 27702810 DOI: 10.1093/Cercor/Bhw297  0.689
2016 Kort NS, Ford JM, Roach BJ, Gunduz-Bruce H, Krystal JH, Jaeger J, Reinhart RM, Mathalon DH. Role of N-Methyl D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia. Biological Psychiatry. PMID 27647218 DOI: 10.1016/J.Biopsych.2016.06.019  0.324
2016 Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry. PMID 27631148 DOI: 10.4088/Jcp.15M10188  0.306
2016 Gerin MI, Fichtenholtz H, Roy A, Walsh CJ, Krystal JH, Southwick S, Hampson M. Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers in Psychiatry. 7: 111. PMID 27445868 DOI: 10.3389/Fpsyt.2016.00111  0.301
2016 Heinz A, Voss M, Lawrie SM, Mishara A, Bauer M, Gallinat J, Juckel G, Lang U, Rapp M, Falkai P, Strik W, Krystal J, Abi-Dargham A, Galderisi S. Shall we really say goodbye to first rank symptoms? European Psychiatry : the Journal of the Association of European Psychiatrists. 37: 8-13. PMID 27429167 DOI: 10.1016/J.Eurpsy.2016.04.010  0.315
2016 Scott JC, Woods SP, Wrocklage KM, Schweinsburg BC, Southwick SM, Krystal JH. Prospective Memory in Posttraumatic Stress Disorder. Journal of the International Neuropsychological Society : Jins. 1-11. PMID 27353125 DOI: 10.1017/S1355617716000564  0.702
2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, et al. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry. 80: 84-6. PMID 27346079 DOI: 10.1016/J.Biopsych.2016.05.004  0.629
2016 Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry. 80: 2-3. PMID 27312230 DOI: 10.1016/J.Biopsych.2016.03.2103  0.411
2016 Mota NP, Tsai J, Sareen J, Marx BP, Wisco BE, Harpaz-Rotem I, Southwick SM, Krystal JH, Pietrzak RH. High burden of subthreshold DSM-5 post-traumatic stress disorder in U.S. military veterans. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 15: 185-186. PMID 27265715 DOI: 10.1002/Wps.20313  0.319
2016 Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Human Brain Mapping. PMID 27144347 DOI: 10.1002/Hbm.23235  0.656
2016 Abdallah CG, Adams TG, Kelmendi B, Esterlis I, Sanacora G, Krystal JH. KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS. Depression and Anxiety. PMID 27062302 DOI: 10.1002/Da.22501  0.548
2016 Rich AM, Cho YT, Tang Y, Savic A, Krystal JH, Wang F, Xu K, Anticevic A. Amygdala volume is reduced in early course schizophrenia. Psychiatry Research. 250: 50-60. PMID 27035063 DOI: 10.1016/J.Pscychresns.2016.02.006  0.582
2016 Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine. 22: 238-49. PMID 26937618 DOI: 10.1038/Nm.4050  0.58
2016 Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC. Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal of the International Neuropsychological Society : Jins. 1-13. PMID 26892753 DOI: 10.1017/S1355617716000059  0.661
2016 Southwick SM, Sippel L, Krystal J, Charney D, Mayes L, Pietrzak R. Why are some individuals more resilient than others: the role of social support. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 15: 77-9. PMID 26833614 DOI: 10.1002/Wps.20282  0.383
2016 Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. The Lancet. Psychiatry. PMID 26803397 DOI: 10.1016/S2215-0366(15)00471-X  0.683
2016 Chekroud A, Zotti R, Shehzad Z, Gueorguieva R, Johnson M, Trivedi M, Cannon T, Krystal J, Corlett P. Cross-trial prediction of treatment outcomes in depression F1000research. 5. DOI: 10.7490/F1000Research.1111949.1  0.669
2016 Krystal JH, Sanacora G, Abdallah C, Duman R. Speaker 4: John Krystal, USA. The International Journal of Neuropsychopharmacology. 19: 19-19. DOI: 10.1093/Ijnp/Pyw042.052  0.488
2016 Krystal JH, Anticevic A, Yang G, Driesen N, Cortes-Briones J, Stone JM, Wang X, Murray JD. Speaker 3: John Krystal, USA The International Journal of Neuropsychopharmacology. 19: 5-5. DOI: 10.1093/Ijnp/Pyw042.007  0.629
2015 Southwick SM, Pietrzak RH, Charney DS, Krystal JH. Resilience: The role of accurate appraisal, thresholds, and socioenvironmental factors. The Behavioral and Brain Sciences. 38: e122. PMID 26786005 DOI: 10.1017/S0140525X14001708  0.414
2015 Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699491 DOI: 10.1073/Pnas.1508436113  0.7
2015 Krystal JH, Anticevic A. Toward Illness Phase-Specific Pharmacotherapy for Schizophrenia. Biological Psychiatry. 78: 738-40. PMID 26542740 DOI: 10.1016/J.Biopsych.2015.08.017  0.56
2015 Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS. Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. Plos Biology. 13: e1002282. PMID 26506154 DOI: 10.1371/Journal.Pbio.1002282  0.329
2015 Corbin WR, Papova A, Morean ME, O'Malley SS, Krishnan-Sarin S, Abi-Dargham A, Anticevic A, Pearlson G, Petrakis I, Pittman BP, Krystal JH. Integrating Acquired Preparedness and Dual Process Models of Risk for Heavy Drinking and Related Problems. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. PMID 26348221 DOI: 10.1037/Adb0000093  0.542
2015 Stone J, Kotoula V, Dietrich C, De Simoni S, Krystal JH, Mehta MA. Perceptual distortions and delusional thinking following ketamine administration are related to increased pharmacological MRI signal changes in the parietal lobe. Journal of Psychopharmacology (Oxford, England). 29: 1025-8. PMID 26152321 DOI: 10.1177/0269881115592337  0.323
2015 Chekroud AM, Krystal JH. Personalised pharmacotherapy: an interim solution for antidepressant treatment? Bmj (Clinical Research Ed.). 350: h2502. PMID 25976040 DOI: 10.1136/Bmj.H2502  0.687
2015 Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 25953357 DOI: 10.1038/Npp.2015.132  0.336
2015 Abdallah CG, Averill LA, Krystal JH. Ketamine as a promising prototype for a new generation of rapid-acting antidepressants. Annals of the New York Academy of Sciences. 1344: 66-77. PMID 25727103 DOI: 10.1111/Nyas.12718  0.339
2015 Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang XJ, Huang X, Lui S, Krystal JH, et al. Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 267-86. PMID 25568120 DOI: 10.1523/Jneurosci.2310-14.2015  0.711
2015 Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry. 76: 546-53. PMID 25562376 DOI: 10.4088/Jcp.14M09091  0.309
2015 Xu K, Krystal JH, Ning Y, Chen da C, He H, Wang D, Ke X, Zhang X, Ding Y, Liu Y, Gueorguieva R, Wang Z, Limoncelli D, Pietrzak RH, Petrakis IL, et al. Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia. Journal of Psychiatric Research. 61: 64-72. PMID 25560772 DOI: 10.1016/J.Jpsychires.2014.12.012  0.321
2015 Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, Krystal JH, Schweinsburg BC. A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder. Psychological Bulletin. 141: 105-40. PMID 25365762 DOI: 10.1037/A0038039  0.658
2015 Abdallah CG, Sanacora G, Duman RS, Krystal JH. Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics. Annual Review of Medicine. 66: 509-23. PMID 25341010 DOI: 10.1146/Annurev-Med-053013-062946  0.567
2015 Anticevic A, Corlett PR, Cole MW, Savic A, Gancsos M, Tang Y, Repovs G, Murray JD, Driesen NR, Morgan PT, Xu K, Wang F, Krystal JH. N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia. Biological Psychiatry. 77: 569-80. PMID 25281999 DOI: 10.1016/J.Biopsych.2014.07.022  0.6
2015 DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biological Psychiatry. 77: 266-75. PMID 25156701 DOI: 10.1016/J.Biopsych.2014.06.024  0.541
2015 Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophrenia Bulletin. 41: 133-43. PMID 24782562 DOI: 10.1093/Schbul/Sbu051  0.714
2014 Pietrzak RH, Rosenheck RA, Cramer JA, Vessichio JC, Tsai J, Southwick SM, Krystal JH. Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: Findings from VA cooperative study 504 - risperidone treatment for military service related chronic post traumatic stress disorder. Journal of Affective Disorders. 172: 331-336. PMID 25451434 DOI: 10.1016/J.Jad.2014.10.025  0.325
2014 Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate metabolism in major depressive disorder. The American Journal of Psychiatry. 171: 1320-7. PMID 25073688 DOI: 10.1176/Appi.Ajp.2014.14010067  0.575
2014 Morean ME, DeMartini KS, Leeman RF, Pearlson GD, Anticevic A, Krishnan-Sarin S, Krystal JH, O'Malley SS. Psychometrically improved, abbreviated versions of three classic measures of impulsivity and self-control. Psychological Assessment. 26: 1003-20. PMID 24885848 DOI: 10.1037/Pas0000003  0.53
2014 Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 111: 7438-43. PMID 24799682 DOI: 10.1073/Pnas.1405289111  0.697
2014 Leatherman SM, Liang MH, Krystal JH, Lew RA, Valley D, Thwin SS, Rosenheck RA. Differences in treatment effect among clinical subgroups in a randomized clinical trial of long-acting injectable risperidone and oral antipsychotics in unstable chronic schizophrenia. The Journal of Nervous and Mental Disease. 202: 13-7. PMID 24375206 DOI: 10.1097/Nmd.0000000000000069  0.325
2014 Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia. Schizophrenia Bulletin. 40: 1105-16. PMID 24366718 DOI: 10.1093/Schbul/Sbt165  0.598
2014 Boggs DL, Carlson J, Cortes-Briones J, Krystal JH, D'Souza DC. Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia. Current Pharmaceutical Design. 20: 5077-92. PMID 24345265 DOI: 10.2174/1381612819666131216121019  0.312
2014 Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry. 75: 595-605. PMID 24314349 DOI: 10.1016/J.Biopsych.2013.10.021  0.581
2014 Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cerebral Cortex (New York, N.Y. : 1991). 24: 3116-30. PMID 23825317 DOI: 10.1093/Cercor/Bht165  0.601
2014 Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model. Cerebral Cortex (New York, N.Y. : 1991). 24: 859-72. PMID 23203979 DOI: 10.1093/Cercor/Bhs370  0.597
2014 Anticevic A, Murray J, Repovs G, Starc M, Santamauro N, Savic A, Morgan P, Wang X, Krystal J. 5:45 PM INTEGRATING PHARMACOLOGY AND COMPUTATION: TOWARDS UNDERSTANDING MECHANISMS OF COGNITIVE AND CONNECTIVITY DEFICITS IN SCHIZOPHRENIA Schizophrenia Research. 153: S52-S53. DOI: 10.1016/S0920-9964(14)70172-0  0.565
2013 Anticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Frontiers in Psychiatry. 4: 169. PMID 24399974 DOI: 10.3389/Fpsyt.2013.00169  0.708
2013 Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2613-22. PMID 23856634 DOI: 10.1038/Npp.2013.170  0.594
2013 Krystal JH, Sanacora G, Duman RS. Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond. Biological Psychiatry. 73: 1133-41. PMID 23726151 DOI: 10.1016/J.Biopsych.2013.03.026  0.569
2013 Narayanan B, Stevens MC, Jiantonio RE, Krystal JH, Pearlson GD. Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. Journal of Studies On Alcohol and Drugs. 74: 245-57. PMID 23384372 DOI: 10.15288/Jsad.2013.74.245  0.307
2013 Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry. 18: 1199-204. PMID 23337947 DOI: 10.1038/Mp.2012.194  0.607
2013 Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 931-40. PMID 23089076 DOI: 10.1016/J.Euroneuro.2012.09.008  0.316
2013 Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. 73: 565-73. PMID 22980587 DOI: 10.1016/J.Biopsych.2012.07.031  0.617
2012 Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16: 584-92. PMID 23142417 DOI: 10.1016/J.Tics.2012.10.008  0.557
2012 Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 109: 16720-5. PMID 23012427 DOI: 10.1073/Pnas.1208494109  0.599
2012 Moghaddam B, Krystal JH. Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophrenia Bulletin. 38: 942-9. PMID 22899397 DOI: 10.1093/Schbul/Sbs075  0.344
2012 Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research. 141: 8-14. PMID 22863548 DOI: 10.1016/J.Schres.2012.07.007  0.592
2012 Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biological Psychiatry. 72: 964-70. PMID 22784486 DOI: 10.1016/J.Biopsych.2012.05.028  0.586
2012 Nestler EJ, Krystal JH. Planning the new national institute on substance use and addiction disorders. Biological Psychiatry. 72: 166-7. PMID 22683089 DOI: 10.1016/J.Biopsych.2012.05.011  0.438
2012 Stone JM, Dietrich C, Edden R, Mehta MA, De Simoni S, Reed LJ, Krystal JH, Nutt D, Barker GJ. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Molecular Psychiatry. 17: 664-5. PMID 22212598 DOI: 10.1038/Mp.2011.171  0.305
2012 Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH. Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 996-1004. PMID 22089316 DOI: 10.1038/Npp.2011.283  0.311
2012 Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic modulation of auditory information processing in the human brain. Biological Psychiatry. 71: 969-77. PMID 22036036 DOI: 10.1016/J.Biopsych.2011.09.031  0.322
2012 Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla. Biological Psychiatry. 71: 239-46. PMID 21855054 DOI: 10.1016/J.Biopsych.2011.06.026  0.53
2011 Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, ... ... Krystal JH, et al. Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences. 1236: 30-43. PMID 22032400 DOI: 10.1111/J.1749-6632.2011.06216.X  0.467
2011 Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A. The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding. Archives of General Psychiatry. 68: 892-900. PMID 21893657 DOI: 10.1001/Archgenpsychiatry.2011.91  0.311
2011 Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot JD, Bailey CR, Krystal JH, Carson RE, Neumeister A. Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biological Psychiatry. 70: 1033-8. PMID 21855859 DOI: 10.1016/J.Biopsych.2011.07.003  0.324
2011 Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, et al. Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders. Biological Psychiatry. 70: 7-12. PMID 21529781 DOI: 10.1016/J.Biopsych.2011.01.041  0.303
2011 Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS. Psychiatry Research. 191: 122-7. PMID 21232924 DOI: 10.1016/J.Pscychresns.2010.10.009  0.578
2011 Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abrão J, Crippa JA, McGuire P, Krystal JH, Baker GB, Zuardi AW. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35: 198-202. PMID 21062637 DOI: 10.1016/J.Pnpbp.2010.11.002  0.342
2011 Larkin G, Beautrais A, Turelli R, Sanacora G, Powsner S, Lippmann M, Krystal J. A preliminary naturalistic study of low-dose ketamine for depression and suicide ideation in the emergency department European Psychiatry. 26: 1607-1607. DOI: 10.1016/S0924-9338(11)73311-9  0.562
2010 Sewell RA, Perry EB, Karper LP, Bell MD, Lysaker P, Goulet JL, Brenner L, Erdos J, d'Souza DC, Seibyl JP, Krystal JH. Clinical significance of neurological soft signs in schizophrenia: factor analysis of the Neurological Evaluation Scale. Schizophrenia Research. 124: 1-12. PMID 20855185 DOI: 10.1016/J.Schres.2010.08.036  0.322
2010 Krystal JH, Mathew SJ, D'Souza DC, Garakani A, Gunduz-Bruce H, Charney DS. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. Cns Drugs. 24: 669-93. PMID 20658799 DOI: 10.2165/11533230-000000000-00000  0.515
2010 Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A prospective cohort study investigating factors associated with depression during medical internship. Archives of General Psychiatry. 67: 557-65. PMID 20368500 DOI: 10.1001/Archgenpsychiatry.2010.41  0.302
2010 Aikins DE, Anticevic A, Kiehl KA, Krystal JH. Sex-related differences in amygdala activity influences immediate memory. Neuroreport. 21: 273-6. PMID 20093991 DOI: 10.1097/Wnr.0B013E328335B3F9  0.535
2010 Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. Journal of Affective Disorders. 121: 175-9. PMID 19577308 DOI: 10.1016/J.Jad.2009.06.010  0.325
2010 Larkin G, Beautrais A, Powsner S, Sanacora G, Krystal J, Turelli R, Lippmann M. 157: A Prospective Open Label Trial of Low Dose Ketamine for Acute Suicidal States In the Emergency Department Annals of Emergency Medicine. 56: S53. DOI: 10.1016/J.ANNEMERGMED.2010.06.204  0.46
2010 Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target of the pharmacotherapy of anxiety disorders, mood disorders and schizophrenia | Neuroplastyczność jako cel dla farmakoterapii zaburzeń lȩkowych, zaburzeń nastroju i schizofrenii Wiadomosci Psychiatryczne. 13: 163-173.  0.527
2009 Zuo L, Luo X, Kranzler HR, Lu L, Rosenheck RA, Cramer J, van Kammen DP, Erdos J, Charney DS, Krystal J, Gelernter J. Association study of DTNBP1 with schizophrenia in a US sample. Psychiatric Genetics. 19: 292-304. PMID 19862852 DOI: 10.1097/Ypg.0B013E32832A50Bc  0.461
2009 Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Drug Discovery Today. 14: 690-7. PMID 19460458 DOI: 10.1016/J.Drudis.2009.05.002  0.581
2009 Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics and Genomics. 19: 437-46. PMID 19369910 DOI: 10.1097/Fpc.0B013E32832B9Cfc  0.47
2009 Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, ... Krystal JH, et al. Population admixture modulates risk for alcohol dependence. Human Genetics. 125: 605-13. PMID 19306106 DOI: 10.1007/S00439-009-0647-4  0.467
2008 Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. Biological Psychiatry. 64: 1026-34. PMID 18823880 DOI: 10.1016/J.Biopsych.2008.07.029  0.318
2008 Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the treatment of mood and anxiety disorders. Cns Drugs. 22: 761-86. PMID 18698875 DOI: 10.2165/00023210-200822090-00004  0.593
2008 Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews. Drug Discovery. 7: 426-37. PMID 18425072 DOI: 10.1038/Nrd2462  0.572
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/J.Biopsych.2008.03.005  0.673
2008 Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study. Psychopharmacology. 197: 401-8. PMID 18176855 DOI: 10.1007/S00213-007-1047-X  0.327
2008 Krystal JH, Gueorguieva R, Cramer J, Collins J, Rosenheck R. Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism". Alcoholism, Clinical and Experimental Research. 32: 85-91. PMID 18070245 DOI: 10.1111/J.1530-0277.2007.00555.X  0.321
2007 Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials. Journal of Clinical Psychopharmacology. 27: 582-9. PMID 18004124 DOI: 10.1097/Jcp.0B013E31815Abf34  0.324
2007 Ford JM, Krystal JH, Mathalon DH. Neural synchrony in schizophrenia: from networks to new treatments. Schizophrenia Bulletin. 33: 848-52. PMID 17567628 DOI: 10.1093/Schbul/Sbm062  0.3
2007 Pittenger C, Sanacora G, Krystal JH. The NMDA receptor as a therapeutic target in major depressive disorder. Cns & Neurological Disorders Drug Targets. 6: 101-15. PMID 17430148 DOI: 10.2174/187152707780363267  0.581
2007 Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, Krystal JH. Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms. Biological Psychiatry. 61: 822-5. PMID 17141740 DOI: 10.1016/J.Biopsych.2006.08.037  0.572
2006 Krystal JH, D'Souza DC, Gallinat J, Driesen N, Abi-Dargham A, Petrakis I, Heinz A, Pearlson G. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotoxicity Research. 10: 235-52. PMID 17197373 DOI: 10.1007/Bf03033360  0.328
2006 Neumeister A, Carson R, Henry S, Planeta-Wilson B, Binneman B, Maguire RP, Luckenbaugh DA, D'Souza C, Krystal JH, Frost JJ. Cerebral metabolic effects of intravenous glycine in healthy human subjects. Journal of Clinical Psychopharmacology. 26: 595-9. PMID 17110816 DOI: 10.1097/01.Jcp.0000245558.14284.Aa  0.336
2006 D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2767-75. PMID 16985503 DOI: 10.1038/Sj.Npp.1301207  0.309
2006 Rasmusson AM, Pinna G, Paliwal P, Weisman D, Gottschalk C, Charney D, Krystal J, Guidotti A. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biological Psychiatry. 60: 704-13. PMID 16934764 DOI: 10.1016/J.Biopsych.2006.03.026  0.48
2006 Morgan CJ, Perry EB, Cho HS, Krystal JH, D'Souza DC. Greater vulnerability to the amnestic effects of ketamine in males. Psychopharmacology. 187: 405-14. PMID 16896964 DOI: 10.1007/S00213-006-0409-0  0.306
2006 Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacology, Biochemistry, and Behavior. 84: 635-43. PMID 16860856 DOI: 10.1016/J.Pbb.2006.06.007  0.319
2006 Pittenger C, Naungayan C, Kendell SF, Coric V, Malison R, Krystal JH, Sanacora GS. Visual hallucinations from the addition of riluzole to memantine and bupropion. Journal of Clinical Psychopharmacology. 26: 218-20. PMID 16633160 DOI: 10.1097/01.Jcp.0000203228.64117.9F  0.488
2006 Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 69-81. PMID 16490414 DOI: 10.1016/J.Nurx.2005.12.006  0.339
2006 Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biological Psychiatry. 59: 611-8. PMID 16414030 DOI: 10.1016/J.Biopsych.2005.08.031  0.462
2006 Krystal JH, Madonick S, Perry E, Gueorguieva R, Brush L, Wray Y, Belger A, D'Souza DC. Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1793-800. PMID 16395307 DOI: 10.1038/Sj.Npp.1300994  0.565
2006 Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology. 184: 254-6. PMID 16374600 DOI: 10.1007/S00213-005-0246-6  0.587
2006 Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF. Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biological Psychiatry. 59: 284-6. PMID 16139814 DOI: 10.1016/J.Biopsych.2005.07.015  0.565
2005 Cho RY, Ford JM, Krystal JH, Laruelle M, Cuthbert B, Carter CS. Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia. Schizophrenia Bulletin. 31: 865-9. PMID 16166611 DOI: 10.1093/Schbul/Sbi050  0.305
2005 Krystal JH, Perry EB, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, Macdougall L, Abi-Saab W, D'Souza DC. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Archives of General Psychiatry. 62: 985-94. PMID 16143730 DOI: 10.1001/Archpsyc.62.9.985  0.576
2005 Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH. Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biological Psychiatry. 58: 424-8. PMID 15993857 DOI: 10.1016/J.Biopsych.2005.04.043  0.573
2005 Bressan RA, Erlandsson K, Stone JM, Mulligan RS, Krystal JH, Ell PJ, Pilowsky LS. Impact of schizophrenia and chronic antipsychotic treatment on [123I]CNS-1261 binding to N-methyl-D-aspartate receptors in vivo. Biological Psychiatry. 58: 41-6. PMID 15992521 DOI: 10.1016/J.Biopsych.2005.03.016  0.326
2005 Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry. 57: 1029-40. PMID 15860344 DOI: 10.1016/J.Biopsych.2005.01.035  0.341
2005 D'Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biological Psychiatry. 57: 594-608. PMID 15780846 DOI: 10.1016/J.Biopsych.2004.12.006  0.346
2005 Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion On Therapeutic Targets. 9: 153-68. PMID 15757488 DOI: 10.1517/14728222.9.1.153  0.579
2005 Cho HS, D'Souza DC, Gueorguieva R, Perry EB, Madonick S, Karper LP, Abi-Dargham A, Belger A, Abi-Saab W, Lipschitz D, Bennet A, Seibyl JP, Krystal JH. Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology. 179: 136-43. PMID 15682309 DOI: 10.1007/S00213-004-2066-5  0.559
2005 Epperson CN, O'Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry. 57: 44-8. PMID 15607299 DOI: 10.1016/J.Biopsych.2004.09.021  0.529
2005 Krystal JH, Abi-Saab W, Perry E, D'Souza DC, Liu N, Gueorguieva R, McDougall L, Hunsberger T, Belger A, Levine L, Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology. 179: 303-9. PMID 15309376 DOI: 10.1007/S00213-004-1982-8  0.567
2004 Sanacora G, Kendell SF, Fenton L, Coric V, Krystal JH. Riluzole augmentation for treatment-resistant depression. The American Journal of Psychiatry. 161: 2132. PMID 15514421 DOI: 10.1176/Appi.Ajp.161.11.2132  0.527
2004 Blumberg HP, Kaufman J, Martin A, Charney DS, Krystal JH, Peterson BS. Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Annals of the New York Academy of Sciences. 1021: 376-83. PMID 15251913 DOI: 10.1196/Annals.1308.048  0.465
2004 Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry. 61: 705-13. PMID 15237082 DOI: 10.1001/Archpsyc.61.7.705  0.571
2004 D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1558-72. PMID 15173844 DOI: 10.1038/Sj.Npp.1300496  0.371
2004 Lappalainen J, Sanacora G, Kranzler HR, Malison R, Hibbard ES, Price LH, Krystal J, Gelernter J. Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 124: 81-6. PMID 14681921 DOI: 10.1002/Ajmg.B.20055  0.543
2004 Petrakis IL, O'Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal JH. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology. 172: 291-7. PMID 14634716 DOI: 10.1007/S00213-003-1658-9  0.303
2004 Hoffman RE, Mathalon DH, Ford JM, Krystal JH. Cortico – (thalamo) – cortical interactions, gamma resonance, and auditory hallucinations in schizophrenia Behavioral and Brain Sciences. 27: 797-798. DOI: 10.1017/S0140525X04320182  0.31
2003 Sanacora G, Rothman DL, Mason G, Krystal JH. Clinical studies implementing glutamate neurotransmission in mood disorders. Annals of the New York Academy of Sciences. 1003: 292-308. PMID 14684453 DOI: 10.1196/Annals.1300.018  0.57
2003 Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry. 60: 1201-8. PMID 14662552 DOI: 10.1001/Archpsyc.60.12.1201  0.474
2003 Harvey PD, Geyer MA, Robbins TW, Krystal JH. Cognition in schizophrenia: from basic science to clinical treatment. Psychopharmacology. 169: 213-4. PMID 12955286 DOI: 10.1007/S00213-003-1581-0  0.304
2003 Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology. 169: 215-33. PMID 12955285 DOI: 10.1007/S00213-003-1582-Z  0.584
2003 Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2020-8. PMID 12888778 DOI: 10.1038/Sj.Npp.1300252  0.456
2003 Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. The American Journal of Psychiatry. 160: 1345-7. PMID 12832254 DOI: 10.1176/Appi.Ajp.160.7.1345  0.49
2003 Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry. 60: 601-9. PMID 12796223 DOI: 10.1001/Archpsyc.60.6.601  0.498
2003 Sierra M, Phillips ML, Ivin G, Krystal J, David AS. A placebo-controlled, cross-over trial of lamotrigine in depersonalization disorder. Journal of Psychopharmacology (Oxford, England). 17: 103-5. PMID 12680746 DOI: 10.1177/0269881103017001712  0.33
2003 Coric V, Milanovic S, Wasylink S, Patel P, Malison R, Krystal JH. Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder. Psychopharmacology. 167: 219-20. PMID 12658528 DOI: 10.1007/S00213-003-1396-Z  0.321
2003 Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM, Krystal JH. Increased cortical GABA concentrations in depressed patients receiving ECT. The American Journal of Psychiatry. 160: 577-9. PMID 12611844 DOI: 10.1176/Appi.Ajp.160.3.577  0.554
2003 Rasmusson A, Guidotti A, Charney D, Vojvoda D, Lipschitz D, Weisman D, Krystal J. S.20.01 Adrenal & CSF neurosteroids as mediators of HPA axis upregulation and symptom production in premenopausal women with PTSD European Neuropsychopharmacology. 13. DOI: 10.1016/S0924-977X(03)91680-4  0.421
2003 Krystal J, D'Souza DH, Mathalon DH, Belger A, Perry E. S.01.03 Therapeutic implications of the NMDA receptor antagonist model psychosis European Neuropsychopharmacology. 13. DOI: 10.1016/S0924-977X(03)91600-2  0.536
2002 Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars in Clinical Neuropsychiatry. 7: 243-54. PMID 12382207 DOI: 10.1053/Scnp.2002.35220  0.508
2002 Lappalainen J, Kranzler HR, Malison R, Price LH, Van Dyck C, Rosenheck RA, Cramer J, Southwick S, Charney D, Krystal J, Gelernter J. A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States. Archives of General Psychiatry. 59: 825-31. PMID 12215082 DOI: 10.1001/Archpsyc.59.9.825  0.419
2002 Abi-Saab W, Seibyl JP, D'Souza DC, Karper LP, Gueorgueva R, Abi-Dargham A, Wong ML, Rajhans S, Erdos JP, Heninger GR, Charney DS, Krystal JH. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology. 162: 55-62. PMID 12107618 DOI: 10.1007/S00213-002-1057-7  0.474
2002 Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Archives of General Psychiatry. 59: 663-4. PMID 12090822 DOI: 10.1001/Archpsyc.59.7.663  0.316
2002 Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry. 7: S71-80. PMID 11986998 DOI: 10.1038/Sj.Mp.4001021  0.65
2002 Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH. Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biological Psychiatry. 51: 642-51. PMID 11955464 DOI: 10.1016/S0006-3223(01)01292-6  0.436
2002 Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. The American Journal of Psychiatry. 159: 663-5. PMID 11925309 DOI: 10.1176/Appi.Ajp.159.4.663  0.553
2001 Chambers RA, Krystal JH, Self DW. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry. 50: 71-83. PMID 11526998 DOI: 10.1016/S0006-3223(01)01134-9  0.34
2001 Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Archives of General Psychiatry. 58: 556-61. PMID 11386984 DOI: 10.1001/Archpsyc.58.6.556  0.463
2001 Stine SM, Grillon CG, Morgan CA, Kosten TR, Charney DS, Krystal JH. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology. 154: 274-81. PMID 11351934 DOI: 10.1007/S002130000644  0.461
2001 Krystal JH, D'Souza DC, Sanacora G, Goddard AW, Charney DS. Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders. The Medical Clinics of North America. 85: 559-77. PMID 11349473 DOI: 10.1016/S0025-7125(05)70329-1  0.652
2000 Sanacora G, Mason GF, Krystal JH. Impairment of GABAergic transmission in depression: new insights from neuroimaging studies. Critical Reviews in Neurobiology. 14: 23-45. PMID 11253954 DOI: 10.1615/Critrevneurobiol.V14.I1.20  0.574
2000 Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH, Charney DS. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet. 355: 1073-5. PMID 10744097 DOI: 10.1016/S0140-6736(00)02043-2  0.449
2000 Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Archives of General Psychiatry. 57: 270-6. PMID 10711913 DOI: 10.1001/Archpsyc.57.3.270  0.477
2000 D'Souza DC, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper LP, Zuzarte E, Charney DS, Krystal JH. IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry. 47: 450-62. PMID 10704956 DOI: 10.1016/S0006-3223(99)00133-X  0.456
2000 Laruelle M, Abi-Dargham A, van Dyck C, Gil R, D'Souza DC, Krystal J, Seibyl J, Baldwin R, Innis R. Dopamine and serotonin transporters in patients with schizophrenia: an imaging study with [(123)I]beta-CIT. Biological Psychiatry. 47: 371-9. PMID 10704949 DOI: 10.1016/S0006-3223(99)00257-7  0.313
2000 Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry. 47: 351-4. PMID 10686270 DOI: 10.1016/S0006-3223(99)00230-9  0.482
2000 Krystal JH, Bennett A, Abi-Saab D, Belger A, Karper LP, D'Souza DC, Lipschitz D, Abi-Dargham A, Charney DS. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry. 47: 137-43. PMID 10664830 DOI: 10.1016/S0006-3223(99)00097-9  0.638
2000 Anand A, Berman R, Charney D, Krystal J. Attenuation of ketamine effects in healthy humans by lamotrigine, a drug that reduces glutamate release Schizophrenia Research. 41: 33. DOI: 10.1016/S0920-9964(00)90372-4  0.429
2000 Hoffman R, Boutros N, Berman R, Hu S, Rachid F, Schaffer N, Krystal J, Charney D. 401. One Hertz rTMS of left temporoparietal cortex in schizophrenic patients reporting auditory hallucinations Biological Psychiatry. 47: S122-S123. DOI: 10.1016/S0006-3223(00)00670-3  0.428
2000 Sanacora G, Mason G, Rothman D, Epperson C, Goddard A, Krystal J. 305. Reduced cortical GABA in depression is not due to decreased gray matter Biological Psychiatry. 47: S92. DOI: 10.1016/S0006-3223(00)00569-2  0.545
2000 Mason G, Sanacora G, Anand A, Epperson C, Goddard A, Rothman D, Charney D, Krystal J. 304. Cortical GABA reduced in unipolar but not bipolar depression Biological Psychiatry. 47: S92. DOI: 10.1016/S0006-3223(00)00568-0  0.551
2000 Belger A, Krystal J. 203. Working memory: constructs, neural circuits, and pharmacological modulation Biological Psychiatry. 47: S62. DOI: 10.1016/S0006-3223(00)00295-X  0.451
1999 Verhoeff NP, Soares JC, D'Souza CD, Gil R, Degen K, Abi-Dargham A, Zoghbi SS, Fujita M, Rajeevan N, Seibyl JP, Krystal JH, van Dyck CH, Charney DS, Innis RB. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research. 91: 163-73. PMID 10641580 DOI: 10.1016/S0925-4927(99)00027-X  0.487
1999 Boutros NN, Belger A, Campbell D, D'Souza C, Krystal J. Comparison of four components of sensory gating in schizophrenia and normal subjects: a preliminary report. Psychiatry Research. 88: 119-30. PMID 10622348 DOI: 10.1016/S0165-1781(99)00074-8  0.563
1999 Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of General Psychiatry. 56: 1043-7. PMID 10565505 DOI: 10.1001/Archpsyc.56.11.1043  0.622
1999 Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars in Clinical Neuropsychiatry. 4: 274-81. PMID 10553033 DOI: 10.153/SCNP00400274  0.402
1999 Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars in Clinical Neuropsychiatry. 4: 242-8. PMID 10553029 DOI: 10.153/SCNP00400242  0.413
1999 D'Souza DC, Berman RM, Krystal JH, Charney DS. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry. 46: 1060-80. PMID 10536743 DOI: 10.1016/S0006-3223(99)00209-7  0.475
1999 Krystal JH, D'Souza DC, Petrakis IL, Belger A, Berman RM, Charney DS, Abi-Saab W, Madonick S. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review of Psychiatry. 7: 125-43. PMID 10483932 DOI: 10.3109/Hrp.7.3.125  0.645
1999 Krystal JH, D'Souza DC, Karper LP, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers MB, Vegso S, Heninger GR, Charney DS. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology. 145: 193-204. PMID 10463321 DOI: 10.1007/S002130051049  0.485
1999 Delgado PL, Miller HL, Salomon RM, Licinio J, Krystal JH, Moreno FA, Heninger GR, Charney DS. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry. 46: 212-20. PMID 10418696 DOI: 10.1016/S0006-3223(99)00014-1  0.365
1999 Hoffman RE, Boutros NN, Berman RM, Roessler E, Belger A, Krystal JH, Charney DS. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated "voices". Biological Psychiatry. 46: 130-2. PMID 10394483 DOI: 10.1016/S0006-3223(98)00358-8  0.604
1999 Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. The American Journal of Psychiatry. 156: 952-4. PMID 10360140 DOI: 10.1176/Ajp.156.6.952  0.448
1999 Abi-Dargham A, Laruelle M, Krystal J, D'Souza C, Zoghbi S, Baldwin RM, Seibyl J, Mawlawi O, de Erasquin G, Charney D, Innis RB. No evidence of altered in vivo benzodiazepine receptor binding in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 20: 650-61. PMID 10327433 DOI: 10.1016/S0893-133X(98)00107-9  0.491
1999 Fujita M, Woods SW, Verhoeff NP, Abi-Dargham A, Baldwin RM, Zoghbi SS, Soares JC, Jatlow PA, Krystal JH, Rajeevan N, Charney DS, Seibyl JP, Innis RB. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal of Pharmacology. 368: 161-72. PMID 10193652 DOI: 10.1016/S0014-2999(99)00013-8  0.444
1999 Sanacora G, Rothman D, Krystal JH. Applications of magnetic resonance spectroscopy to psychiatry Neuroscientist. 5: 192-196. DOI: 10.1177/107385849900500316  0.518
1999 Sanacora G, Mason GF, Rothman DL, Berman RM, Charney DS, Ciarcia JJ, Krystal JH. 1. ECT Effects on Cortical GABA Levels as Determined by 1H-MRS The Journal of Ect. 15: 102. DOI: 10.1097/00124509-199903000-00009  0.594
1999 Krystal JH, Belger A, D'Souza DC, Anand A, Charney DS, Aghajanian GK, Moghaddam B. Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists Neuropsychopharmacology. 21: S143-S157. DOI: 10.1016/S0893-133X(99)00102-5  0.644
1998 Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. The American Journal of Psychiatry. 155: 1550-5. PMID 9812116 DOI: 10.1176/Ajp.155.11.1550  0.44
1998 Abi-Saab WM, D'Souza DC, Moghaddam B, Krystal JH. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry. 31: 104-9. PMID 9754841 DOI: 10.1055/S-2007-979354  0.362
1998 Belger A, Puce A, Krystal JH, Gore JC, Goldman-Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping. 6: 14-32. PMID 9673660 DOI: 10.1002/(Sici)1097-0193(1998)6:1<14::Aid-Hbm2>3.0.Co;2-O  0.518
1998 Abi-Dargham A, Gil R, Krystal J, Baldwin RM, Seibyl JP, Bowers M, van Dyck CH, Charney DS, Innis RB, Laruelle M. Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort. The American Journal of Psychiatry. 155: 761-7. PMID 9619147 DOI: 10.1176/Ajp.155.6.761  0.466
1998 Sernyak MJ, Glazer WM, Heninger GR, Charney DS, Woods SW, Petrakis IL, Krystal JH, Price LH. Naltrexone augmentation of neuroleptics in schizophrenia. Journal of Clinical Psychopharmacology. 18: 248-51. PMID 9617985 DOI: 10.1097/00004714-199806000-00011  0.487
1998 Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, Stetson P, Trevisan LA, Charney DS. Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics. Archives of General Psychiatry. 55: 354-60. PMID 9554431 DOI: 10.1001/Archpsyc.55.4.354  0.449
1998 Krystal JH, Karper LP, Bennett A, D'Souza DC, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner JD, Bowers MB, Suckow RF, Stetson P, Heninger GR, Charney DS. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology. 135: 213-29. PMID 9498724 DOI: 10.1007/s002130050503  0.419
1998 Bremner JD, Krystal JH, Putnam FW, Southwick SM, Marmar C, Charney DS, Mazure CM. Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS). Journal of Traumatic Stress. 11: 125-36. PMID 9479681 DOI: 10.1023/A:1024465317902  0.458
1998 Belger A, Kirino E, McCarthy G, Gore J, Krystal J. Assessment of prefrontal activation by infrequent visual targets and non-target novel stimuli in schizophrenia: A functional MRI study Schizophrenia Research. 29: 106. DOI: 10.1016/S0920-9964(97)88567-2  0.539
1998 D'Souza D, Belger A, Abi-Saab W, Adams S, Gil R, Larvey K, Cassello K, Sernyak M, Krystal J. 435. Dose-response of THC effects in schizophrenics and healthy controls Biological Psychiatry. 43: S130-S131. DOI: 10.1016/S0006-3223(98)90883-6  0.515
1998 Hoffman R, Boutros N, Berman R, Krystal J, Charney D. 310. Transcranial magnetic stimulation and hallucinated ‘voices’ Biological Psychiatry. 43: S93. DOI: 10.1016/S0006-3223(98)90758-2  0.385
1998 Krystal J, Moghaddam B, Breier A, Goldman-Rakic P, McElvey J. 204. Glutamate, dopamine, the frontal cortex, and schizophrenia Biological Psychiatry. 43: S60. DOI: 10.1016/S0006-3223(98)90652-7  0.303
1998 Sanacora G, Goddard A, Gil R, D'Souza D, Abi-Saab W, Petroff O, Mattson R, Mason G, Behar K, Ciarcia J, Berman R, Charney D, Rothman D, Krystal J. 24. Quantification of cortical GABA levels in neuropsychiatric patients Biological Psychiatry. 43: S8. DOI: 10.1016/S0006-3223(98)90472-3  0.527
1997 Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, Johnson DR, Heninger GR, Charney DS. Noradrenergic and serotonergic function in posttraumatic stress disorder. Archives of General Psychiatry. 54: 749-58. PMID 9283511 DOI: 10.1001/Archpsyc.1997.01830200083012  0.476
1997 Southwick SM, Morgan CA, Bremner AD, Grillon CG, Krystal JH, Nagy LM, Charney DS. Noradrenergic alterations in posttraumatic stress disorder. Annals of the New York Academy of Sciences. 821: 125-41. PMID 9238199 DOI: 10.1111/J.1749-6632.1997.Tb48274.X  0.454
1997 Krystal JH, Webb E, Grillon C, Cooney N, Casal L, Morgan CA, Southwick SM, Davis M, Charney DS. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-chlorophenylpiperazine (mCPP). Psychopharmacology. 131: 207-15. PMID 9203230 DOI: 10.1007/S002130050285  0.471
1997 Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. The American Journal of Psychiatry. 154: 624-9. PMID 9137116 DOI: 10.1176/Ajp.154.5.624  0.454
1997 Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Archives of General Psychiatry. 54: 364-74. PMID 9107153 DOI: 10.1001/Archpsyc.1997.01830160092012  0.392
1997 Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Archives of General Psychiatry. 54: 246-54. PMID 9075465  0.405
1997 Salomon RM, Miller HL, Krystal JH, Heninger GR, Charney DS. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry. 41: 58-64. PMID 8988796 DOI: 10.1016/0006-3223(95)00670-2  0.443
1997 Abi-Dargham A, Charney DS, Krystal JH. Benzodiazepine Receptor Antagonists Cns Drugs. 8: 244-256. DOI: 10.2165/00023210-199708030-00007  0.421
1997 Zuzarte E, Cyril D’Souza D, Gil R, White J, AbiSaab D, Charney DS, Krystal JH. Evaluation of lorazepam blockade of M-chlorophenylpiperazine (MCPP) effects in schizophrenia Schizophrenia Research. 24: 218. DOI: 10.1016/S0920-9964(97)82626-6  0.446
1997 Zuzarte E, Cyril D’Souza D, Gil R, Genovese A, White J, Charney DS, Krystal JH. Dose-related ethanol effects in schizophrenic patients Schizophrenia Research. 24: 218. DOI: 10.1016/S0920-9964(97)82625-4  0.414
1997 Laruelle M, Abi-Dargham A, Krystal JH, Charney DS, Innis RB. In vivo evaluation of dopamine synaptic funcflon in untreated schizophrenic patients Schizophrenia Research. 24: 179. DOI: 10.1016/S0920-9964(97)82515-7  0.416
1997 Belger A, Taqqu Y, Krystal JH. Behavioral dissociation of working memory and selective attention functions in schizophrenia Schizophrenia Research. 24: 129-130. DOI: 10.1016/S0920-9964(97)82365-1  0.542
1997 Belger A, McNulty A, Krystal JH. Behavioral assessment of frontal/ cingulate attention deficits in schizophrenia Schizophrenia Research. 24: 129. DOI: 10.1016/S0920-9964(97)82364-X  0.547
1996 Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal of Clinical Psychiatry. 57: 23-31; discussion 32. PMID 8917129  0.412
1996 Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. The Journal of Neuropsychiatry and Clinical Neurosciences. 8: 60-6. PMID 8845703 DOI: 10.1176/Jnp.8.1.60  0.372
1996 Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt W, Fingado C, Zoghbi SS, Baldwin RM, Seibyl JP, Krystal JH, Charney DS, Innis RB. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings of the National Academy of Sciences of the United States of America. 93: 9235-40. PMID 8799184 DOI: 10.1073/Pnas.93.17.9235  0.469
1996 Krystal JH, Compere S, Nestler EJ, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior. 59: 863-6. PMID 8778878 DOI: 10.1016/0031-9384(95)02206-6  0.41
1996 Bremner JD, Krystal JH, Southwick SM, Charney DS. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse (New York, N.Y.). 23: 39-51. PMID 8723134 DOI: 10.1002/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I  0.408
1996 Bremner JD, Krystal JH, Southwick SM, Charney DS. Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse (New York, N.Y.). 23: 28-38. PMID 8723133 DOI: 10.1002/(Sici)1098-2396(199605)23:1<28::Aid-Syn4>3.0.Co;2-J  0.482
1996 Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". The American Journal of Psychiatry. 153: 71-82. PMID 8659644 DOI: 10.1176/Ajp.153.7.71  0.358
1996 Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Archives of General Psychiatry. 53: 117-28. PMID 8629887 DOI: 10.1001/Archpsyc.1996.01830020031005  0.452
1996 Lam RW, Zis AP, Grewal A, Delgado PL, Charney DS, Krystal JH. Effects of rapid tryptophan depletion in patients with seasonal affective disorder in remission after light therapy. Archives of General Psychiatry. 53: 41-4. PMID 8540776 DOI: 10.1001/Archpsyc.1996.01830010043007  0.461
1996 Krystal JH, Webb E, Cooney NL, Kranzler HR, Southwick SW, Heninger GR, Charney DS. Serotonergic and noradrenergic dysregulation in alcoholism: m-chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. The American Journal of Psychiatry. 153: 83-92. PMID 8540598 DOI: 10.1176/Ajp.153.1.83  0.432
1996 Petrakis IL, Satel SL, Stine S, Kosten TR, Namanworth SN, Charney DS, Krystal JH. AMPT Effects on Cue-Induced Craving for Cocaine The American Journal On Addictions. 5: 313-320. DOI: 10.1111/J.1521-0391.1996.Tb00317.X  0.41
1995 Bremner JD, Krystal JH, Southwick SM, Charney DS. Functional neuroanatomical correlates of the effects of stress on memory. Journal of Traumatic Stress. 8: 527-53. PMID 8564272 DOI: 10.1007/Bf02102888  0.452
1995 Stine SM, Krystal JH, Kosten TR, Charney DS. Mazindol treatment for cocaine dependence Drug and Alcohol Dependence. 39: 245-252. PMID 8556974 DOI: 10.1016/0376-8716(95)01174-4  0.434
1995 Salomon RM, Delgado PL, Licinio J, Krystal JH, Heninger GR, Charney DS. Effects of sleep deprivation on serotonin function in depression. Biological Psychiatry. 36: 840-6. PMID 7893848 DOI: 10.1016/0006-3223(94)90595-9  0.446
1995 Krystal JH, Woods SW, Kosten TR, Rosen MI, Seibyl JP, van Dyck CC, Price LH, Zubal IG, Hoffer PB, Charney DS. Opiate dependence and withdrawal: preliminary assessment using single photon emission computerized tomography (SPECT). The American Journal of Drug and Alcohol Abuse. 21: 47-63. PMID 7762544 DOI: 10.3109/00952999509095229  0.387
1995 Satel SL, Krystal JH, Delgado PL, Kosten TR, Charney DS. Tryptophan depletion and attenuation of cue-induced craving for cocaine. The American Journal of Psychiatry. 152: 778-83. PMID 7726319 DOI: 10.1176/Ajp.152.5.778  0.395
1995 Morgan CA, Grillon C, Southwick SM, Nagy LM, Davis M, Krystal JH, Charney DS. Yohimbine facilitated acoustic startle in combat veterans with post-traumatic stress disorder Psychopharmacology. 117: 466-471. PMID 7604149 DOI: 10.1007/Bf02246220  0.404
1995 Goddard AW, Charney DS, Germine M, Woods SW, Heninger GR, Krystal JH, Goodman WK, Price LH. Effects of tryptophan depletion on responses to yohimbine in healthy human subjects Biological Psychiatry. 38: 74-85. PMID 7578653 DOI: 10.1016/0006-3223(94)00223-P  0.446
1995 Randall PK, Bremner JD, Krystal JH, Nagy LM, Heninger GR, Nicolaou AL, Charney DS. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry. 38: 319-24. PMID 7495926 DOI: 10.1016/0006-3223(94)00306-N  0.493
1995 D'Souza DC, Charney D, Krystal J. Glycine Site Agonists of the NMDA Receptor: A Review Cns Drug Reviews. 1: 227-260. DOI: 10.1111/J.1527-3458.1995.Tb00285.X  0.424
1995 Belger A, McCarthy G, Gore J, Puce A, Constable T, Krystal J. Evaluation of frontal and parietal association cortex contributions to attention using fMRI Schizophrenia Research. 15: 76. DOI: 10.1016/0920-9964(95)95239-6  0.521
1994 Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB, Charney DS. Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Archives of General Psychiatry. 51: 199-214. PMID 8122957 DOI: 10.1001/Archpsyc.1994.03950030035004  0.455
1994 Krystal JH, Webb E, Cooney N, Kranzler HR, Charney DS. Specificity of ethanollike effects elicited by serotonergic and noradrenergic mechanisms. Archives of General Psychiatry. 51: 898-911. PMID 7944878 DOI: 10.1001/Archpsyc.1994.03950110058008  0.455
1994 Southwick SM, Bremner D, Krystal JH, Charney DS. Psychobiologic research in post-traumatic stress disorder Psychiatric Clinics of North America. 17: 251-264. PMID 7937357 DOI: 10.1016/S0193-953X(18)30112-6  0.505
1994 Krystal JH, Southwick SM, Charney DS. Alcohol Dependence May Be the Missing Link between Posttraumatic Stress Disorder and Panic-Reply Archives of General Psychiatry. 51: 430. DOI: 10.1001/Archpsyc.1994.03950050090014  0.51
1993 Charney DS, Deutch AY, Krystal JH, Southwick SM, Davis M. Psychobiologic Mechanisms of Posttraumatic Stress Disorder Archives of General Psychiatry. 50: 294-305. PMID 8466391 DOI: 10.1001/Archpsyc.1993.01820160064008  0.475
1993 Southwick SM, Krystal JH, Morgan CA, Johnson D, Nagy LM, Nicolaou A, Heninger GR, Charney DS. Abnormal noradrenergic function in posttraumatic stress disorder. Archives of General Psychiatry. 50: 266-74. PMID 8466387 DOI: 10.1001/Archpsyc.1993.01820160036003  0.484
1993 Yehuda R, Southwick SM, Krystal JH, Bremner D, Charney DS, Mason JW. Enhanced suppression of cortisol following dexamethasone administration in posttraumatic stress disorder. The American Journal of Psychiatry. 150: 83-6. PMID 8417586 DOI: 10.1176/Ajp.150.1.83  0.491
1993 Licinio J, Seibyl JP, Altemus M, Charney DS, Krystal JH. Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients. The American Journal of Psychiatry. 150: 1408-10. PMID 8102512 DOI: 10.1176/ajp.150.9.1408  0.374
1993 Krystal JH, Seibyl JP, Price LH, Woods SW, Heninger GR, Aghajanian GK, Charney DS. m-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Evidence implicating serotonergic systems in the positive symptoms of schizophrenia. Archives of General Psychiatry. 50: 624-35. PMID 8102048 DOI: 10.1001/Archpsyc.1993.01820200034004  0.507
1993 Seibyl JP, Satel SL, Anthony D, Southwick SM, Krystal JH, Charney DS. Effects of cocaine on hospital course in schizophrenia. The Journal of Nervous and Mental Disease. 181: 31-7. PMID 8093475 DOI: 10.1097/00005053-199301000-00006  0.43
1993 Morgan CA, Southwick SM, Grillon C, Davis M, Krystal JH, Charney DS. Yohimbine - facilitated acoustic startle reflex in humans Psychopharmacology. 110: 342-346. PMID 7831429 DOI: 10.1007/Bf02251291  0.387
1993 NAGY LM, KRYSTAL JH, CHARNEY DS, MERIKANGAS KR, WOODS SW. Long-Term Outcome of Panic Disorder After Short-Term Imipramine and Behavioral Group Treatment Journal of Clinical Psychopharmacology. 13: 16???24. DOI: 10.1097/00004714-199302000-00003  0.449
1992 Woods SW, Nagy LM, Koleszar AS, Krystal JH, Heninger GR, Charney DS. Controlled trial of alprazolam supplementation during imipramine treatment of panic disorder Journal of Clinical Psychopharmacology. 12: 32-38. PMID 1552038 DOI: 10.1097/00001573-199202000-00006  0.476
1992 Krystal JH, Leaf PJ, Bruce ML, Charney DS. Effects of age and alcoholism on the prevalence of panic disorder. Acta Psychiatrica Scandinavica. 85: 77-82. PMID 1546554 DOI: 10.1111/J.1600-0447.1992.Tb01447.X  0.387
1992 Seibyl JP, Brenner L, Krystal JH, Johnson R, Charney DS. Mazindol and cocaine addiction in schizophrenia. Biological Psychiatry. 31: 1179-81. PMID 1525287 DOI: 10.1016/0006-3223(92)90171-U  0.433
1992 Grillon C, Ameli R, Charney DS, Krystal J, Braff D. Startle gating deficits occur across prepulse intensities in schizophrenic patients. Biological Psychiatry. 32: 939-43. PMID 1467378 DOI: 10.1016/0006-3223(92)90183-Z  0.436
1992 Krystal JH, Price LH, Opsahl C, Ricaurte GA, Heninger GR. Chronic 3,4-methylenedioxymethamphetamine (MDMA) use: effects on mood and neuropsychological function? The American Journal of Drug and Alcohol Abuse. 18: 331-41. PMID 1357957 DOI: 10.3109/00952999209026070  0.305
1992 Krystal JH, McDougle CJ, Woods SW, Price LH, Heninger GR, Charney DS. Dose-response relationship for oral idazoxan effects in healthy human subjects: comparison with oral yohimbine Psychopharmacology. 108: 313-319. PMID 1355923 DOI: 10.1007/Bf02245117  0.452
1992 Charney DS, Woods SW, Krystal JH, Nagy LM, Heninger GR. Noradrenergic neuronal dysregulation in panic disorder: The effects of intravenous yohimbine and clonidine in panic disorder patients Acta Psychiatrica Scandinavica. 86: 273-282. PMID 1333719 DOI: 10.1111/J.1600-0447.1992.Tb03266.X  0.478
1992 Krystal JH, McDougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS. Baclofen-assisted detoxification from opiates. A pilot study. Journal of Substance Abuse Treatment. 9: 139-42. PMID 1324986 DOI: 10.1016/0740-5472(92)90081-X  0.442
1991 Satel SL, Price LH, Palumbo JM, McDougle CJ, Krystal JH, Gawin F, Charney DS, Heninger GR, Kleber HD. Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study. The American Journal of Psychiatry. 148: 1712-6. PMID 1957935 DOI: 10.1176/Ajp.148.12.1712  0.416
1991 Woods SW, Charney DS, Silver JM, Krystal JH, Heninger GR. Behavioral, biochemical, and cardiovascular responses to the benzodiazepine receptor antagonist flumazenil in panic disorder Psychiatry Research. 36: 115-127. PMID 1850142 DOI: 10.1016/0165-1781(91)90124-8  0.47
1991 Krystal JH, Woods SW, Hill CL, Charney DS. Characteristics of panic attack subtypes: Assessment of spontaneous panic, situational panic, sleep panic, and limited symptom attacks Comprehensive Psychiatry. 32: 474-480. PMID 1778074 DOI: 10.1016/0010-440X(91)90026-9  0.447
1991 Seibyl JP, Krystal JH, Price LH, Woods SW, D'Amico C, Heninger GR, Charney DS. Effects of ritanserin on the behavioral, neuroendocrine, and cardiovascular responses to meta-chlorophenylpiperazine in healthy human subjects Psychiatry Research. 38: 227-236. PMID 1754635 DOI: 10.1016/0165-1781(91)90013-F  0.439
1991 Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research. 4: 121-56. PMID 1674882 DOI: 10.1016/0920-9964(91)90030-U  0.452
1991 Licinio J, Krystal J, Seibyl J, Altemus M, Charney D. Elevated central levels of interleukin-2 in drug-free schizophrenic patients Schizophrenia Research. 4: 372. DOI: 10.1016/0920-9964(91)90301-7  0.332
1991 Krystal J, Seibyl J, Price L, Woods S, Heninger G, Charney D. MCPP effects in schizophrenic patients before and after typical and atypical neuroleptic treatment Schizophrenia Research. 4: 350. DOI: 10.1016/0920-9964(91)90266-T  0.367
1991 Nagy LM, Krystal JH, Charney DS, Woods SW. Follow-up Study of Patients With Panic Disorder-Reply Archives of General Psychiatry. 48: 861-862. DOI: 10.1001/Archpsyc.1991.01810330085018  0.443
1990 Kosten TR, Krystal JH, Charney DS, Price LH, Morgan CH, Kleber HD. Opioid antagonist challenges in buprenorphine maintained patients. Drug and Alcohol Dependence. 25: 73-8. PMID 2323312 DOI: 10.1016/0376-8716(90)90144-4  0.433
1990 Seibyl JP, Krystal JH, Charney DS. Marijuana (cannabis) use is anecdotally said to precipitate anxiety symptoms in patients with panic disorder. Is there any research evidence to support this? Also, can marijuana use precipitate or expose paranoia in patients with an underlying bipolar disorder? Journal of Clinical Psychopharmacology. 10: 78. PMID 2307743 DOI: 10.1097/00004714-199002000-00033  0.481
1990 Charney DS, Woods SW, Krystal JH, Heninger GR. Serotonin function and human anxiety disorders Annals of the New York Academy of Sciences. 600: 558-573. PMID 2252335 DOI: 10.1111/J.1749-6632.1990.Tb16910.X  0.457
1990 Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical studies of 5-HT function using I.V. l-Tryptophan Progress in Neuropsychopharmacology and Biological Psychiatry. 14: 459-472. PMID 2236580 DOI: 10.1016/0278-5846(90)90002-X  0.442
1990 Charney DS, Krystal JH, Delgado PL, Heninger GR. Serotonin-specific drugs for anxiety and depressive disorders Annual Review of Medicine. 41: 437-446. PMID 2139556 DOI: 10.1146/Annurev.Me.41.020190.002253  0.477
1990 Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2308-17. PMID 2115910 DOI: 10.1523/Jneurosci.10-07-02308.1990  0.419
1990 Goodman WK, Price LH, Delgado PL, Palumbo J, Krystal JH, Nagy LM, Rasmussen SA, Heninger GR, Charney DS. Specificity of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder. Comparison of fluvoxamine and desipramine. Archives of General Psychiatry. 47: 577-85. PMID 2112374 DOI: 10.1001/Archpsyc.1990.01810180077011  0.51
1990 McDougle CJ, Goodman WK, Price LH, Delgado PL, Krystal JH, Charney DS, Heninger GR. Neuroleptic addition in fluvoxamine-refractory obsessive-compulsive disorder. The American Journal of Psychiatry. 147: 652-4. PMID 1970224 DOI: 10.1176/Ajp.147.5.652  0.473
1989 Nagy LM, Krystal JH, Woods SW, Charney DS. Clinical and Medication Outcome After Short-term Alprazolam and Behavorial Group Treatment in Panic Disorder: 2.5-Year Naturalistic Follow-up Study Archives of General Psychiatry. 46: 993-999. PMID 2818144 DOI: 10.1001/Archpsyc.1989.01810110035005  0.486
1989 Seibyl JP, Krystal JH, Price LH, Charney DS. Use of yohimbine to counteract nortriptyline-induced orthostatic hypotension Journal of Clinical Psychopharmacology. 9: 67-68. PMID 2708559 DOI: 10.1097/00004714-198902000-00026  0.398
1989 Woods SW, Krystal JH, Heninger GR, Charney DS. Effects of alprazolam and clonidine on carbon dioxide-induced increases in anxiety ratings in healthy human subjects Life Sciences. 45: 233-242. PMID 2503670 DOI: 10.1016/0024-3205(89)90255-5  0.444
1989 Koster K, Woods SW, Smith EO, Zubal IG, Krystal JH, Charney DS, Hoffer PB. REGIONAL CEREBRAL BLOOD FLOW CHANGES IN PATIENTS WITH PANIC DISORDER Clinical Nuclear Medicine. 14: 234. DOI: 10.1097/00003072-198903000-00039  0.433
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