John H. Krystal, M.D. - Publications

Affiliations: 
Psychiatry Yale University, New Haven, CT 

409 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ji JL, Diehl C, Schleifer C, Tamminga CA, Keshavan MS, Sweeney JA, Clementz BA, Hill SK, Pearlson G, Yang G, Creatura G, Krystal JH, Repovs G, Murray J, Winkler A, et al. Schizophrenia Exhibits Bi-directional Brain-Wide Alterations in Cortico-Striato-Cerebellar Circuits. Cerebral Cortex (New York, N.Y. : 1991). PMID 31157363 DOI: 10.1093/cercor/bhy306  0.92
2019 Abdallah CG, Averill CL, Ramage AE, Averill LA, Goktas S, Nemati S, Krystal JH, Roache JD, Resick PA, Young-McCaughan S, Peterson AL, Fox P. Salience Network Disruption in U.S. Army Soldiers With Posttraumatic Stress Disorder. Chronic Stress (Thousand Oaks, Calif.). 3. PMID 31131337 DOI: 10.1177/2470547019850467  0.52
2019 Davis MT, Hillmer A, Holmes SE, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Angarita-Africano G, Carson RE, Krystal JH, Esterlis I. In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31085640 DOI: 10.1073/pnas.1818871116  0.52
2019 Krystal JH, Yoon G, Petrakis IL. Rigorous Trial Design Is Essential to Understand the Role of Opioid Receptors in Ketamine's Antidepressant Effect-Reply. Jama Psychiatry. PMID 31042270 DOI: 10.1001/jamapsychiatry.2019.0763  0.4
2019 Abdallah CG, Averill CL, Ramage AE, Averill LA, Alkin E, Nemati S, Krystal JH, Roache JD, Resick P, Young-McCaughan S, Peterson AL, Fox P. Reduced Salience and Enhanced Central Executive Connectivity Following PTSD Treatment. Chronic Stress (Thousand Oaks, Calif.). 3. PMID 31008419 DOI: 10.1177/2470547019838971  0.52
2019 Abdallah CG, Roache JD, Averill LA, Young-McCaughan S, Martini B, Gueorguieva R, Amoroso T, Southwick SM, Guthmiller K, López-Roca AL, Lautenschlager K, Mintz J, Litz BT, Williamson DE, Keane TM, ... ... Krystal JH, et al. Repeated ketamine infusions for antidepressant-resistant PTSD: Methods of a multicenter, randomized, placebo-controlled clinical trial. Contemporary Clinical Trials. PMID 30999057 DOI: 10.1016/j.cct.2019.04.009  0.8
2019 Holmes SE, Scheinost D, Finnema SJ, Naganawa M, Davis MT, DellaGioia N, Nabulsi N, Matuskey D, Angarita GA, Pietrzak RH, Duman RS, Sanacora G, Krystal JH, Carson RE, Esterlis I. Lower synaptic density is associated with depression severity and network alterations. Nature Communications. 10: 1529. PMID 30948709 DOI: 10.1038/s41467-019-09562-7  0.68
2019 Duman RS, Sanacora G, Krystal JH. Altered Connectivity in Depression: GABA and Glutamate Neurotransmitter Deficits and Reversal by Novel Treatments. Neuron. 102: 75-90. PMID 30946828 DOI: 10.1016/j.neuron.2019.03.013  0.68
2019 Fleming LM, Javitt DC, Carter CS, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Robinson J, Potter WZ, Carlson M, Wall MM, Choo TH, ... ... Krystal JH, et al. A multicenter study of ketamine effects on functional connectivity: Large scale network relationships, hubs and symptom mechanisms. Neuroimage. Clinical. 22: 101739. PMID 30852397 DOI: 10.1016/j.nicl.2019.101739  0.36
2019 Krystal JH, Abdallah CG, Sanacora G, Charney DS, Duman RS. Ketamine: A Paradigm Shift for Depression Research and Treatment. Neuron. 101: 774-778. PMID 30844397 DOI: 10.1016/j.neuron.2019.02.005  0.8
2019 Tamman AJF, Montalvo-Ortiz JL, Southwick SM, Krystal JH, Levy BR, Pietrzak RH. Accelerated DNA Methylation Aging in U.S. Military Veterans: Results From the National Health and Resilience in Veterans Study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 30792041 DOI: 10.1016/j.jagp.2019.01.001  0.8
2019 Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Author Correction: Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience. PMID 30760852 DOI: 10.1038/s41593-019-0356-9  0.52
2019 Tang Y, Zhou Q, Chang M, Chekroud A, Gueorguieva R, Jiang X, Zhou Y, He G, Rowland M, Wang D, Fu S, Yin Z, Leng H, Wei S, Xu K, ... ... Krystal JH, et al. Altered functional connectivity and low-frequency signal fluctuations in early psychosis and genetic high risk. Schizophrenia Research. PMID 30685394 DOI: 10.1016/j.schres.2018.12.041  0.48
2019 Homan P, Levy I, Feltham E, Gordon C, Hu J, Li J, Pietrzak RH, Southwick S, Krystal JH, Harpaz-Rotem I, Schiller D. Neural computations of threat in the aftermath of combat trauma. Nature Neuroscience. PMID 30664770 DOI: 10.1038/s41593-018-0315-x  0.52
2019 Yoon G, Petrakis IL, Krystal JH. Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder. Jama Psychiatry. PMID 30624551 DOI: 10.1001/jamapsychiatry.2018.3990  0.4
2018 Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Correction: Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30487654 DOI: 10.1038/s41386-018-0253-z  0.48
2018 Averill CL, Averill LA, Wrocklage KM, Scott JC, Akiki TJ, Schweinsburg B, Southwick SM, Krystal JH, Abdallah CG. Altered White Matter Diffusivity of the Cingulum Angular Bundle in Posttraumatic Stress Disorder. Molecular Neuropsychiatry. 4: 75-82. PMID 30397595 DOI: 10.1159/000490464  0.8
2018 Pitts BL, Whealin JM, Harpaz-Rotem I, Duman RS, Krystal JH, Southwick SM, Pietrzak RH. BDNF Val66Met polymorphism and posttraumatic stress symptoms in U.S. military veterans: Protective effect of physical exercise. Psychoneuroendocrinology. 100: 198-202. PMID 30388593 DOI: 10.1016/j.psyneuen.2018.10.011  0.8
2018 Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Topology of brain functional connectivity networks in posttraumatic stress disorder. Data in Brief. 20: 1658-1675. PMID 30364328 DOI: 10.1016/j.dib.2018.08.198  0.8
2018 Preller KH, Burt JB, Ji JL, Schleifer CH, Adkinson BD, Stämpfli P, Seifritz E, Repovs G, Krystal JH, Murray JD, Vollenweider FX, Anticevic A. Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor. Elife. 7. PMID 30355445 DOI: 10.7554/eLife.35082  0.92
2018 Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Physical activity and mental health - Author's reply. The Lancet. Psychiatry. PMID 30245184 DOI: 10.1016/S2215-0366(18)30354-7  1
2018 Abdallah CG, Averill LA, Akiki TJ, Raza M, Averill CL, Gomaa H, Adikey A, Krystal JH. The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder. Annual Review of Pharmacology and Toxicology. PMID 30216745 DOI: 10.1146/annurev-pharmtox-010818-021701  0.52
2018 Zhornitsky S, Ide J, Wang W, Chao H, Zhang S, Hu S, Krystal J, Li CR. Problem drinking, alcohol expectancy and thalamic resting-state functional connectivity in non-dependent adult drinkers. Brain Connectivity. PMID 30198312 DOI: 10.1089/brain.2018.0633  0.4
2018 Chekroud SR, Gueorguieva R, Zheutlin AB, Paulus M, Krumholz HM, Krystal JH, Chekroud AM. Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study. The Lancet. Psychiatry. PMID 30099000 DOI: 10.1016/S2215-0366(18)30227-X  1
2018 Holmes SE, Scheinost D, DellaGioia N, Davis MT, Matuskey D, Pietrzak RH, Hampson M, Krystal JH, Esterlis I. Cerebellar and prefrontal cortical alterations in PTSD: structural and functional evidence. Chronic Stress (Thousand Oaks, Calif.). 2. PMID 30035247  0.52
2018 Abdallah CG, De Feyter HM, Averill LA, Jiang L, Averill CL, Chowdhury GMI, Purohit P, de Graaf RA, Esterlis I, Juchem C, Pittman BP, Krystal JH, Rothman DL, Sanacora G, Mason GF. The effects of ketamine on prefrontal glutamate neurotransmission in healthy and depressed subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29977074 DOI: 10.1038/s41386-018-0136-3  0.68
2018 Chekroud AM, Foster D, Zheutlin AB, Gerhard DM, Roy B, Koutsouleris N, Chandra A, Esposti MD, Subramanyan G, Gueorguieva R, Paulus M, Krystal JH. Predicting Barriers to Treatment for Depression in a U.S. National Sample: A Cross-Sectional, Proof-of-Concept Study. Psychiatric Services (Washington, D.C.). appips201800094. PMID 29962307 DOI: 10.1176/appi.ps.201800094  1
2018 Ide JS, Zhornitsky S, Chao HH, Zhang S, Hu S, Wang W, Krystal JH, Li CR. Thalamic Cortical Error-Related Responses in Adult Social Drinkers: Sex Differences and Problem Alcohol Use. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 29859929 DOI: 10.1016/j.bpsc.2018.04.008  0.4
2018 Kegeles LS, Horga G, Ghazzaoui R, Rosengard R, Ojeil N, Xu X, Slifstein M, Petrakis I, O'Malley SS, Krystal JH, Abi-Dargham A. Enhanced Striatal Dopamine Release to Expectation of Alcohol: A Potential Risk Factor for Alcohol Use Disorder. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 29803635 DOI: 10.1016/j.bpsc.2018.03.018  0.36
2018 Abdallah CG, Sanacora G, Duman RS, Krystal JH. The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation? Pharmacology & Therapeutics. PMID 29803629 DOI: 10.1016/j.pharmthera.2018.05.010  0.68
2018 Akiki TJ, Averill CL, Wrocklage KM, Scott JC, Averill LA, Schweinsburg B, Alexander-Bloch A, Martini B, Southwick SM, Krystal JH, Abdallah CG. Default mode network abnormalities in posttraumatic stress disorder: A novel network-restricted topology approach. Neuroimage. PMID 29730491 DOI: 10.1016/j.neuroimage.2018.05.005  0.8
2018 Fuehrlein BS, Kachadourian LK, DeVylder EK, Trevisan LA, Potenza MN, Krystal JH, Southwick SM, Pietrzak RH. Trajectories of alcohol consumption in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. The American Journal On Addictions. PMID 29667712 DOI: 10.1111/ajad.12731  0.8
2018 Morean ME, DeMartini KS, Foster D, Patock-Peckham J, Garrison KA, Corlett PR, Krystal JH, Krishan-Sarin S, O'Malley SS. The Self-Report Habit Index: Assessing habitual marijuana, alcohol, e-cigarette, and cigarette use. Drug and Alcohol Dependence. 186: 207-214. PMID 29609132 DOI: 10.1016/j.drugalcdep.2018.01.014  0.36
2018 Cheng WJ, Chen CH, Chen CK, Huang MC, Pietrzak RH, Krystal JH, Xu K. Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia. Schizophrenia Research. PMID 29510925 DOI: 10.1016/j.schres.2018.02.049  0.52
2018 D'Souza DC, Carson RE, Driesen N, Johannesen J, Ranganathan M, Krystal JH. Dose-Related Target Occupancy and Effects on Circuitry, Behavior, and Neuroplasticity of the Glycine Transporter-1 Inhibitor PF-03463275 in Healthy and Schizophrenia Subjects. Biological Psychiatry. PMID 29499855 DOI: 10.1016/j.biopsych.2017.12.019  0.4
2018 Krystal JH, Abdallah CG, Pietrzak RH, Averill LA, Harpaz-Rotem I, Levy I, Kelmendi B, Southwick SM. Locus Coeruleus Hyperactivity in Posttraumatic Stress Disorder: Answers and Questions. Biological Psychiatry. 83: 197-199. PMID 29277190 DOI: 10.1016/j.biopsych.2017.09.027  0.8
2017 Averill CL, Satodiya RM, Scott JC, Wrocklage KM, Schweinsburg B, Averill LA, Akiki TJ, Amoroso T, Southwick SM, Krystal JH, Abdallah CG. Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 29520395  0.8
2017 Logue MW, van Rooij SJH, Dennis EL, Davis SL, Hayes JP, Stevens JS, Densmore M, Haswell CC, Ipser J, Koch SBJ, Korgaonkar M, Lebois LAM, Peverill M, Baker JT, Boedhoe PSW, ... ... Krystal JH, et al. Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia. Biological Psychiatry. PMID 29217296 DOI: 10.1016/j.biopsych.2017.09.006  0.52
2017 Mota NP, Han S, Harpaz-Rotem I, Maruff P, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Apolipoprotein E gene polymorphism, trauma burden, and posttraumatic stress symptoms in U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Depression and Anxiety. PMID 29172227 DOI: 10.1002/da.22698  0.8
2017 Javitt DC, Carter CS, Krystal JH, Kantrowitz JT, Girgis RR, Kegeles LS, Ragland JD, Maddock RJ, Lesh TA, Tanase C, Corlett PR, Rothman DL, Mason G, Qiu M, Robinson J, et al. Utility of Imaging-Based Biomarkers for Glutamate-Targeted Drug Development in Psychotic Disorders: A Randomized Clinical Trial. Jama Psychiatry. PMID 29167877 DOI: 10.1001/jamapsychiatry.2017.3572  0.36
2017 Yang BZ, Arias AJ, Feinn R, Krystal JH, Gelernter J, Petrakis IL. GRIK1 and GABRA2 Variants Have Distinct Effects on the Dose-Related Subjective Response to Intravenous Alcohol in Healthy Social Drinkers. Alcoholism, Clinical and Experimental Research. PMID 29131352 DOI: 10.1111/acer.13516  0.4
2017 Watkins LE, Han S, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Association Between Functional Polymorphism in Neuropeptide Y Gene Promoter rs16147 and Resilience to Traumatic Stress in US Military Veterans. The Journal of Clinical Psychiatry. 78: e1058-e1059. PMID 29099554 DOI: 10.4088/JCP.17l11646  0.8
2017 Abdallah CG, Averill CL, Salas R, Averill LA, Baldwin PR, Krystal JH, Mathew SJ, Mathalon DH. Prefrontal Connectivity and Glutamate Transmission: Relevance to Depression Pathophysiology and Ketamine Treatment. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 2: 566-574. PMID 29034354 DOI: 10.1016/j.bpsc.2017.04.006  0.52
2017 Taylor JJ, Krystal JH, D'Souza DC, Gerrard JL, Corlett PR. Targeted neural network interventions for auditory hallucinations: Can TMS inform DBS? Schizophrenia Research. PMID 28969932 DOI: 10.1016/j.schres.2017.09.020  0.4
2017 Byrne SP, Krystal JH, Rosenheck RA, Vessicchio J, Pietrzak RH. Correlates of Nonimprovement to Pharmacotherapy for Chronic, Antidepressant-Resistant, Military Service-Related Posttraumatic Stress Disorder: Insights From the Veterans Affairs Cooperative Study No. 504. Journal of Clinical Psychopharmacology. PMID 28945664 DOI: 10.1097/JCP.0000000000000777  0.52
2017 Tamman AJF, Sippel LM, Han S, Neria Y, Krystal JH, Southwick SM, Gelernter J, Pietrzak RH. Attachment style moderates effects of FKBP5 polymorphisms and childhood abuse on posttraumatic stress symptoms: Results from the National Health and Resilience in Veterans Study. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-41. PMID 28891785 DOI: 10.1080/15622975.2017.1376114  0.8
2017 Averill LA, Abdallah CG, Pietrzak RH, Averill CL, Southwick SM, Krystal JH, Harpaz-Rotem I. Combat Exposure Severity is Associated with Reduced Cortical Thickness in Combat Veterans: A Preliminary Report. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 28845475  0.8
2017 Krystal JH, Abdallah CG, Averill LA, Kelmendi B, Harpaz-Rotem I, Sanacora G, Southwick SM, Duman RS. Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic. Current Psychiatry Reports. 19: 74. PMID 28844076 DOI: 10.1007/s11920-017-0829-z  0.8
2017 Akiki TJ, Averill CL, Wrocklage KM, Schweinsburg B, Scott JC, Martini B, Averill LA, Southwick SM, Krystal JH, Abdallah CG. The Association of PTSD Symptom Severity with Localized Hippocampus and Amygdala Abnormalities. Chronic Stress (Thousand Oaks, Calif.). 1. PMID 28825050  0.8
2017 Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, ... ... Krystal JH, et al. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. Jama Psychiatry. PMID 28813562 DOI: 10.1001/jamapsychiatry.2017.2269  0.8
2017 Holmes SE, Girgenti MJ, Davis MT, Pietrzak RH, DellaGioia N, Nabulsi N, Matuskey D, Southwick S, Duman RS, Carson RE, Krystal JH, Esterlis I. Altered metabotropic glutamate receptor 5 markers in PTSD: In vivo and postmortem evidence. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716937 DOI: 10.1073/pnas.1701749114  0.68
2017 Wisco BE, Marx BP, Miller MW, Wolf EJ, Krystal JH, Southwick SM, Pietrzak RH. A comparison of ICD-11 and DSM criteria for posttraumatic stress disorder in two national samples of U.S. military veterans. Journal of Affective Disorders. 223: 17-19. PMID 28715723 DOI: 10.1016/j.jad.2017.07.006  0.8
2017 Sippel LM, Han S, Watkins LE, Harpaz-Rotem I, Southwick SM, Krystal JH, Olff M, Sherva R, Farrer LA, Kranzler HR, Gelernter J, Pietrzak RH. Oxytocin receptor gene polymorphisms, attachment, and PTSD: Results from the National Health and Resilience in Veterans Study. Journal of Psychiatric Research. 94: 139-147. PMID 28715704 DOI: 10.1016/j.jpsychires.2017.07.008  0.8
2017 Petrakis IL, Ralevski E, Gueorguieva R, O'Malley SS, Arias A, Sevarino KA, Jane JS, O'Brien E, Krystal JH. Mecamylamine Treatment for Alcohol Dependence: A Randomized Controlled Trial. Addiction (Abingdon, England). PMID 28710873 DOI: 10.1111/add.13943  0.48
2017 Su TP, Chen MH, Li CT, Lin WC, Hong CJ, Gueorguieva R, Tu PC, Bai YM, Cheng CM, Krystal JH. Dose-Related Effects of Adjunctive Ketamine in Taiwanese Patients with Treatment-Resistant Depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28492279 DOI: 10.1038/npp.2017.94  0.48
2017 Abdallah CG, Southwick SM, Krystal JH. Neurobiology of posttraumatic stress disorder (PTSD): A path from novel pathophysiology to innovative therapeutics. Neuroscience Letters. 649: 130-132. PMID 28478864 DOI: 10.1016/j.neulet.2017.04.046  0.8
2017 Krystal JH, Anticevic A, Yang GJ, Dragoi G, Driesen NR, Wang XJ, Murray JD. Impaired Tuning of Neural Ensembles and the Pathophysiology of Schizophrenia: A Translational and Computational Neuroscience Perspective. Biological Psychiatry. 81: 874-885. PMID 28434616 DOI: 10.1016/j.biopsych.2017.01.004  0.92
2017 Foss-Feig JH, Adkinson BD, Ji JL, Yang G, Srihari VH, McPartland JC, Krystal JH, Murray JD, Anticevic A. Searching for Cross-Diagnostic Convergence: Neural Mechanisms Governing Excitation and Inhibition Balance in Schizophrenia and Autism Spectrum Disorders. Biological Psychiatry. 81: 848-861. PMID 28434615 DOI: 10.1016/j.biopsych.2017.03.005  0.92
2017 Ide JS, Zhornitsky S, Hu S, Zhang S, Krystal JH, Li CR. Sex differences in the interacting roles of impulsivity and positive alcohol expectancy in problem drinking: A structural brain imaging study. Neuroimage. Clinical. 14: 750-759. PMID 28413777 DOI: 10.1016/j.nicl.2017.03.015  0.4
2017 Wisco BE, Marx BP, May CL, Martini B, Krystal JH, Southwick SM, Pietrzak RH. Moral injury in U.S. combat veterans: Results from the national health and resilience in veterans study. Depression and Anxiety. PMID 28370818 DOI: 10.1002/da.22614  0.8
2017 Chekroud AM, Loho H, Krystal JH. Mental illness and mental health. The Lancet. Psychiatry. 4: 276-277. PMID 28347431 DOI: 10.1016/S2215-0366(17)30088-3  1
2017 Krystal JH, Murray JD, Chekroud AM, Corlett PR, Yang G, Wang XJ, Anticevic A. Computational Psychiatry and the Challenge of Schizophrenia. Schizophrenia Bulletin. PMID 28338845 DOI: 10.1093/schbul/sbx025  1
2017 Wrocklage KM, Averill LA, Cobb Scott J, Averill CL, Schweinsburg B, Trejo M, Roy A, Weisser V, Kelly C, Martini B, Harpaz-Rotem I, Southwick SM, Krystal JH, Abdallah CG. Cortical thickness reduction in combat exposed U.S. veterans with and without PTSD. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 28279623 DOI: 10.1016/j.euroneuro.2017.02.010  0.8
2017 Chekroud AM, Gueorguieva R, Krumholz HM, Trivedi MH, Krystal JH, McCarthy G. Reevaluating the Efficacy and Predictability of Antidepressant Treatments: A Symptom Clustering Approach. Jama Psychiatry. PMID 28241180 DOI: 10.1001/jamapsychiatry.2017.0025  1
2017 Gueorguieva R, Chekroud AM, Krystal JH. Trajectories of relapse in randomised, placebo-controlled trials of treatment discontinuation in major depressive disorder: an individual patient-level data meta-analysis. The Lancet. Psychiatry. PMID 28189575 DOI: 10.1016/S2215-0366(17)30038-X  1
2017 Krystal JH, Petrakis IL, O'Malley S, Krishnan-Sarin S, Pearlson G, Yoon G. NMDA glutamate receptor antagonism and the heritable risk for alcoholism: new insights from a study of nitrous oxide. The International Journal of Neuropsychopharmacology. PMID 28158462 DOI: 10.1093/ijnp/pyw118  0.4
2016 Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. 1: 300-301. PMID 29560862 DOI: 10.1016/j.bpsc.2016.03.007  0.64
2016 Abdallah CG, Averill LA, Krystal JH, Southwick SM, Arnsten AF. Glutamate and norepinephrine interaction: Relevance to higher cognitive operations and psychopathology. The Behavioral and Brain Sciences. 39: e201. PMID 28347382 DOI: 10.1017/S0140525X15001727  0.8
2016 Averill LA, Purohit P, Averill CL, Boesl MA, Krystal JH, Abdallah CG. Glutamate Dysregulation and Glutamatergic Therapeutics for PTSD: Evidence from Human Studies. Neuroscience Letters. PMID 27916636 DOI: 10.1016/j.neulet.2016.11.064  0.52
2016 Kelmendi B, Corlett P, Ranganathan M, D'Souza C, Krystal JH. The role of psychedelics in palliative care reconsidered: A case for psilocybin. Journal of Psychopharmacology (Oxford, England). 30: 1212-1214. PMID 27909173 DOI: 10.1177/0269881116675781  0.32
2016 Kelmendi B, Adams TG, Yarnell S, Southwick S, Abdallah CG, Krystal JH. PTSD: from neurobiology to pharmacological treatments. European Journal of Psychotraumatology. 7: 31858. PMID 27837583  0.52
2016 Isaacs K, Mota NP, Tsai J, Harpaz-Rotem I, Cook JM, Kirwin PD, Krystal JH, Southwick SM, Pietrzak RH. Psychological resilience in U.S. military veterans: A 2-year, nationally representative prospective cohort study. Journal of Psychiatric Research. 84: 301-309. PMID 27814502 DOI: 10.1016/j.jpsychires.2016.10.017  0.8
2016 Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research. PMID 27745755 DOI: 10.1016/j.schres.2016.10.011  0.92
2016 Yang GJ, Murray JD, Glasser M, Pearlson GD, Krystal JH, Schleifer C, Repovs G, Anticevic A. Altered Global Signal Topography in Schizophrenia. Cerebral Cortex (New York, N.Y. : 1991). PMID 27702810 DOI: 10.1093/cercor/bhw297  0.92
2016 Watkins LE, Harpaz-Rotem I, Sippel LM, Krystal JH, Southwick SM, Pietrzak RH. Hostility and telomere shortening among U.S. military veterans: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology. 74: 251-257. PMID 27689898 DOI: 10.1016/j.psyneuen.2016.09.006  0.8
2016 Zhang X, Justice AC, Hu Y, Wang Z, Zhao H, Wang G, Johnson EO, Emu B, Sutton RE, Krystal JH, Xu K. Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals. Epigenetics. 1-11. PMID 27672717 DOI: 10.1080/15592294.2016.1221569  0.96
2016 Kort NS, Ford JM, Roach BJ, Gunduz-Bruce H, Krystal JH, Jaeger J, Reinhart RM, Mathalon DH. Role of N-Methyl D-Aspartate Receptors in Action-Based Predictive Coding Deficits in Schizophrenia. Biological Psychiatry. PMID 27647218 DOI: 10.1016/j.biopsych.2016.06.019  0.4
2016 Pietrzak RH, Zhu Y, Slade MD, Qi Q, Krystal JH, Southwick SM, Levy BR. Association Between Negative Age Stereotypes and Accelerated Cellular Aging: Evidence from Two Cohorts of Older Adults. Journal of the American Geriatrics Society. PMID 27641354 DOI: 10.1111/jgs.14452  0.8
2016 Wisco BE, Marx BP, Miller MW, Wolf EJ, Mota NP, Krystal JH, Southwick SM, Pietrzak RH. Probable Posttraumatic Stress Disorder in the US Veteran Population According to DSM-5: Results From the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry. PMID 27631148 DOI: 10.4088/JCP.15m10188  0.8
2016 Sippel LM, Mota NP, Kachadourian LK, Krystal JH, Southwick SM, Harpaz-Rotem I, Pietrzak RH. The burden of hostility in U.S. Veterans: Results from the National Health and Resilience in Veterans Study. Psychiatry Research. 243: 421-430. PMID 27450745 DOI: 10.1016/j.psychres.2016.06.040  0.96
2016 Gerin MI, Fichtenholtz H, Roy A, Walsh CJ, Krystal JH, Southwick S, Hampson M. Real-Time fMRI Neurofeedback with War Veterans with Chronic PTSD: A Feasibility Study. Frontiers in Psychiatry. 7: 111. PMID 27445868 DOI: 10.3389/fpsyt.2016.00111  0.4
2016 Scott JC, Woods SP, Wrocklage KM, Schweinsburg BC, Southwick SM, Krystal JH. Prospective Memory in Posttraumatic Stress Disorder. Journal of the International Neuropsychological Society : Jins. 1-11. PMID 27353125 DOI: 10.1017/S1355617716000564  0.8
2016 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA, Carter CS, Cook EH, Daskalakis ZJ, DiLeone RJ, Duman RS, et al. Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biological Psychiatry. 80: 84-6. PMID 27346079 DOI: 10.1016/j.biopsych.2016.05.004  0.8
2016 Otto MW, Pollack MH, Dowd SM, Hofmann SG, Pearlson G, Szuhany KL, Gueorguieva R, Krystal JH, Simon NM, Tolin DF. RANDOMIZED TRIAL OF D-CYCLOSERINE ENHANCEMENT OF COGNITIVE-BEHAVIORAL THERAPY FOR PANIC DISORDER. Depression and Anxiety. PMID 27315514 DOI: 10.1002/da.22531  0.48
2016 Krystal JH, Abi-Dargham A, Barch DM, Bullmore ET, Carter CS, Geschwind DH, Harrison PJ, Nestler EJ, Stein MB. Biological Psychiatry and Biological Psychiatry: Cognitive Neuroscience and Neuroimaging Adopt Neuroscience-Based Nomenclature. Biological Psychiatry. 80: 2-3. PMID 27312230 DOI: 10.1016/j.biopsych.2016.03.2103  0.8
2016 Mota NP, Tsai J, Sareen J, Marx BP, Wisco BE, Harpaz-Rotem I, Southwick SM, Krystal JH, Pietrzak RH. High burden of subthreshold DSM-5 post-traumatic stress disorder in U.S. military veterans. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 15: 185-186. PMID 27265715 DOI: 10.1002/wps.20313  0.96
2016 Murrough JW, Abdallah CG, Anticevic A, Collins KA, Geha P, Averill LA, Schwartz J, DeWilde KE, Averill C, Jia-Wei Yang G, Wong E, Tang CY, Krystal JH, Iosifescu DV, Charney DS. Reduced global functional connectivity of the medial prefrontal cortex in major depressive disorder. Human Brain Mapping. PMID 27144347 DOI: 10.1002/hbm.23235  0.96
2016 Watkins LE, Han S, Harpaz-Rotem I, Mota NP, Southwick SM, Krystal JH, Gelernter J, Pietrzak RH. FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study. Psychoneuroendocrinology. 69: 98-105. PMID 27078785 DOI: 10.1016/j.psyneuen.2016.04.001  0.96
2016 Abdallah CG, Adams TG, Kelmendi B, Esterlis I, Sanacora G, Krystal JH. KETAMINE'S MECHANISM OF ACTION: A PATH TO RAPID-ACTING ANTIDEPRESSANTS. Depression and Anxiety. PMID 27062302 DOI: 10.1002/da.22501  0.96
2016 Fuehrlein BS, Mota N, Arias AJ, Trevisan LA, Kachadourian LK, Krystal JH, Southwick SM, Pietrzak RH. The burden of alcohol use disorders in U.S. Military veterans: results from the national health and resilience in veterans study. Addiction (Abingdon, England). PMID 27061707 DOI: 10.1111/add.13423  0.96
2016 Mota N, Tsai J, Kirwin PD, Harpaz-Rotem I, Krystal JH, Southwick SM, Pietrzak RH. Late-life exacerbation of PTSD symptoms in US veterans: results from the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry. 77: 348-354. PMID 27046308 DOI: 10.4088/JCP.15m10101  0.8
2016 Rich AM, Cho YT, Tang Y, Savic A, Krystal JH, Wang F, Xu K, Anticevic A. Amygdala volume is reduced in early course schizophrenia. Psychiatry Research. 250: 50-60. PMID 27035063 DOI: 10.1016/j.pscychresns.2016.02.006  0.92
2016 Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine. 22: 238-49. PMID 26937618 DOI: 10.1038/nm.4050  0.68
2016 Wrocklage KM, Schweinsburg BC, Krystal JH, Trejo M, Roy A, Weisser V, Moore TM, Southwick SM, Scott JC. Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes. Journal of the International Neuropsychological Society : Jins. 1-13. PMID 26892753 DOI: 10.1017/S1355617716000059  0.96
2016 Krystal JH, Pietrzak RH, Rosenheck RA, Cramer JA, Vessicchio J, Jones KM, Huang GD, Vertrees JE, Collins J, Krystal AD. Sleep disturbance in chronic military-related PTSD: clinical impact and response to adjunctive risperidone in the Veterans Affairs Cooperative Study #504. The Journal of Clinical Psychiatry. PMID 26890894 DOI: 10.4088/JCP.14m09585  0.8
2016 Hu S, Zhang S, Chao HH, Krystal JH, Li CR. Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers. Alcoholism, Clinical and Experimental Research. PMID 26833431 DOI: 10.1111/acer.12964  0.32
2016 Chekroud AM, Zotti RJ, Shehzad Z, Gueorguieva R, Johnson MK, Trivedi MH, Cannon TD, Krystal JH, Corlett PR. Cross-trial prediction of treatment outcome in depression: a machine learning approach. The Lancet. Psychiatry. PMID 26803397 DOI: 10.1016/S2215-0366(15)00471-X  0.96
2015 Southwick SM, Pietrzak RH, Charney DS, Krystal JH. Resilience: The role of accurate appraisal, thresholds, and socioenvironmental factors. The Behavioral and Brain Sciences. 38: e122. PMID 26786005 DOI: 10.1017/S0140525X14001708  0.8
2015 Yang GJ, Murray JD, Wang XJ, Glahn DC, Pearlson GD, Repovs G, Krystal JH, Anticevic A. Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. PMID 26699491 DOI: 10.1073/pnas.1508436113  0.32
2015 Krystal JH, Anticevic A. Toward Illness Phase-Specific Pharmacotherapy for Schizophrenia. Biological Psychiatry. 78: 738-40. PMID 26542740 DOI: 10.1016/j.biopsych.2015.08.017  0.92
2015 Licznerski P, Duric V, Banasr M, Alavian KN, Ota KT, Kang HJ, Jonas EA, Ursano R, Krystal JH, Duman RS. Decreased SGK1 Expression and Function Contributes to Behavioral Deficits Induced by Traumatic Stress. Plos Biology. 13: e1002282. PMID 26506154 DOI: 10.1371/journal.pbio.1002282  0.68
2015 Yoon G, Pittman B, Limoncelli D, Krystal JH, Petrakis IL. Familial Alcoholism Risk and the Ratio of Stimulant to Sedative Effects of Ketamine. Biological Psychiatry. PMID 26475672 DOI: 10.1016/j.biopsych.2015.09.006  0.32
2015 Corbin WR, Papova A, Morean ME, O'Malley SS, Krishnan-Sarin S, Abi-Dargham A, Anticevic A, Pearlson G, Petrakis I, Pittman BP, Krystal JH. Integrating Acquired Preparedness and Dual Process Models of Risk for Heavy Drinking and Related Problems. Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors. PMID 26348221 DOI: 10.1037/adb0000093  0.32
2015 Zuo L, Zhang CK, Sayward FG, Cheung KH, Wang K, Krystal JH, Zhao H, Luo X. Gene-based and pathway-based genome-wide association study of alcohol dependence. Shanghai Archives of Psychiatry. 27: 111-8. PMID 26120261 DOI: 10.11919/j.issn.1002-0829.215031  0.8
2015 Zuo L, Saba L, Lin X, Tan Y, Wang K, Krystal JH, Tabakoff B, Luo X. Significant association between rare IPO11-HTR1A variants and attention deficit hyperactivity disorder in Caucasians. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 26079129 DOI: 10.1002/ajmg.b.32329  0.8
2015 Chekroud AM, Krystal JH. Personalised pharmacotherapy: an interim solution for antidepressant treatment? Bmj (Clinical Research Ed.). 350: h2502. PMID 25976040 DOI: 10.1136/bmj.h2502  0.96
2015 Krystal JH, Carter CS. Introducing a new journal: biological psychiatry: cognitive neuroscience and neuroimaging. Biological Psychiatry. 77: 922. PMID 25959562 DOI: 10.1016/j.biopsych.2015.04.009  0.8
2015 Krystal JH, Stossel S, Krystal AD. Restricting Benzodiazepines to Short-Term Prescription. Jama Psychiatry. 72: 734-5. PMID 25923129 DOI: 10.1001/jamapsychiatry.2015.0351  0.8
2015 Abdallah CG, Averill LA, Krystal JH. Ketamine as a promising prototype for a new generation of rapid-acting antidepressants. Annals of the New York Academy of Sciences. 1344: 66-77. PMID 25727103 DOI: 10.1111/nyas.12718  0.8
2015 Pietrzak RH, Averill LA, Abdallah CG, Neumeister A, Krystal JH, Levy I, Harpaz-Rotem I. Amygdala-hippocampal volume and the phenotypic heterogeneity of posttraumatic stress disorder: a cross-sectional study. Jama Psychiatry. 72: 396-8. PMID 25692480 DOI: 10.1001/jamapsychiatry.2014.2470  0.8
2015 Krystal JH. Deconstructing N-methyl-d-aspartate glutamate receptor contributions to cortical circuit functions to construct better hypotheses about the pathophysiology of schizophrenia. Biological Psychiatry. 77: 508-10. PMID 25687430 DOI: 10.1016/j.biopsych.2014.10.010  0.8
2015 Krishnan-Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N-methyl-D-aspartate receptor antagonism has differential effects on alcohol craving and drinking in heavy drinkers. Alcoholism, Clinical and Experimental Research. 39: 300-7. PMID 25664775 DOI: 10.1111/acer.12619  0.8
2015 Krystal JH, O'Malley SS. From translational neuroscience to personalized medicine. Alcoholism, Clinical and Experimental Research. 39: 585-6. PMID 25656652 DOI: 10.1111/acer.12667  0.8
2015 Anticevic A, Hu X, Xiao Y, Hu J, Li F, Bi F, Cole MW, Savic A, Yang GJ, Repovs G, Murray JD, Wang XJ, Huang X, Lui S, Krystal JH, et al. Early-course unmedicated schizophrenia patients exhibit elevated prefrontal connectivity associated with longitudinal change. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 267-86. PMID 25568120 DOI: 10.1523/JNEUROSCI.2310-14.2015  0.8
2015 Tsai J, Harpaz-Rotem I, Armour C, Southwick SM, Krystal JH, Pietrzak RH. Dimensional structure of DSM-5 posttraumatic stress disorder symptoms: results from the National Health and Resilience in Veterans Study. The Journal of Clinical Psychiatry. 76: 546-53. PMID 25562376 DOI: 10.4088/JCP.14m09091  0.8
2015 Xu K, Krystal JH, Ning Y, Chen da C, He H, Wang D, Ke X, Zhang X, Ding Y, Liu Y, Gueorguieva R, Wang Z, Limoncelli D, Pietrzak RH, Petrakis IL, et al. Preliminary analysis of positive and negative syndrome scale in ketamine-associated psychosis in comparison with schizophrenia. Journal of Psychiatric Research. 61: 64-72. PMID 25560772 DOI: 10.1016/j.jpsychires.2014.12.012  0.8
2015 Krystal JH. Biological psychiatry: looking good! Biological Psychiatry. 77: 2. PMID 25483341 DOI: 10.1016/j.biopsych.2014.10.007  0.8
2015 Saricicek A, Chen J, Planeta B, Ruf B, Subramanyam K, Maloney K, Matuskey D, Labaree D, Deserno L, Neumeister A, Krystal JH, Gallezot JD, Huang Y, Carson RE, Bhagwagar Z. Test-retest reliability of the novel 5-HT1B receptor PET radioligand [11C]P943. European Journal of Nuclear Medicine and Molecular Imaging. 42: 468-77. PMID 25427881 DOI: 10.1007/s00259-014-2958-5  0.8
2015 Scott JC, Matt GE, Wrocklage KM, Crnich C, Jordan J, Southwick SM, Krystal JH, Schweinsburg BC. A quantitative meta-analysis of neurocognitive functioning in posttraumatic stress disorder. Psychological Bulletin. 141: 105-40. PMID 25365762 DOI: 10.1037/a0038039  0.8
2015 Abdallah CG, Sanacora G, Duman RS, Krystal JH. Ketamine and rapid-acting antidepressants: a window into a new neurobiology for mood disorder therapeutics. Annual Review of Medicine. 66: 509-23. PMID 25341010 DOI: 10.1146/annurev-med-053013-062946  0.8
2015 Anticevic A, Corlett PR, Cole MW, Savic A, Gancsos M, Tang Y, Repovs G, Murray JD, Driesen NR, Morgan PT, Xu K, Wang F, Krystal JH. N-methyl-D-aspartate receptor antagonist effects on prefrontal cortical connectivity better model early than chronic schizophrenia. Biological Psychiatry. 77: 569-80. PMID 25281999 DOI: 10.1016/j.biopsych.2014.07.022  0.8
2015 DeLorenzo C, DellaGioia N, Bloch M, Sanacora G, Nabulsi N, Abdallah C, Yang J, Wen R, Mann JJ, Krystal JH, Parsey RV, Carson RE, Esterlis I. In vivo ketamine-induced changes in [¹¹C]ABP688 binding to metabotropic glutamate receptor subtype 5. Biological Psychiatry. 77: 266-75. PMID 25156701 DOI: 10.1016/j.biopsych.2014.06.024  0.8
2015 Anticevic A, Savic A, Repovs G, Yang G, McKay DR, Sprooten E, Knowles EE, Krystal JH, Pearlson GD, Glahn DC. Ventral anterior cingulate connectivity distinguished nonpsychotic bipolar illness from psychotic bipolar disorder and schizophrenia. Schizophrenia Bulletin. 41: 133-43. PMID 24782562 DOI: 10.1093/schbul/sbu051  0.8
2015 Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine Neuropsychopharmacology. DOI: 10.1038/npp.2015.132  0.8
2014 Cosgrove KP, McKay R, Esterlis I, Kloczynski T, Perkins E, Bois F, Pittman B, Lancaster J, Glahn DC, O'Malley S, Carson RE, Krystal JH. Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 111: 18031-6. PMID 25453062 DOI: 10.1073/pnas.1413947111  0.8
2014 Pietrzak RH, Rosenheck RA, Cramer JA, Vessichio JC, Tsai J, Southwick SM, Krystal JH. Elucidating the transdiagnostic dimensional structure of trauma-related psychopathology: Findings from VA cooperative study 504 - risperidone treatment for military service related chronic post traumatic stress disorder. Journal of Affective Disorders. 172: 331-336. PMID 25451434 DOI: 10.1016/j.jad.2014.10.025  0.8
2014 Wang XJ, Krystal JH. Computational psychiatry. Neuron. 84: 638-54. PMID 25442941 DOI: 10.1016/j.neuron.2014.10.018  0.8
2014 Abdallah CG, Jiang L, De Feyter HM, Fasula M, Krystal JH, Rothman DL, Mason GF, Sanacora G. Glutamate metabolism in major depressive disorder. The American Journal of Psychiatry. 171: 1320-7. PMID 25073688 DOI: 10.1176/appi.ajp.2014.14010067  0.8
2014 Gallezot JD, Esterlis I, Bois F, Zheng MQ, Lin SF, Kloczynski T, Krystal JH, Huang Y, Sabri O, Carson RE, Cosgrove KP. Evaluation of the sensitivity of the novel α4β2* nicotinic acetylcholine receptor PET radioligand 18F-(-)-NCFHEB to increases in synaptic acetylcholine levels in rhesus monkeys. Synapse (New York, N.Y.). 68: 556-64. PMID 25043426 DOI: 10.1002/syn.21767  0.8
2014 Morean ME, DeMartini KS, Leeman RF, Pearlson GD, Anticevic A, Krishnan-Sarin S, Krystal JH, O'Malley SS. Psychometrically improved, abbreviated versions of three classic measures of impulsivity and self-control. Psychological Assessment. 26: 1003-20. PMID 24885848 DOI: 10.1037/pas0000003  0.8
2014 Yang GJ, Murray JD, Repovs G, Cole MW, Savic A, Glasser MF, Pittenger C, Krystal JH, Wang XJ, Pearlson GD, Glahn DC, Anticevic A. Altered global brain signal in schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 111: 7438-43. PMID 24799682 DOI: 10.1073/pnas.1405289111  0.8
2014 Krystal JH, State MW. Psychiatric disorders: diagnosis to therapy. Cell. 157: 201-14. PMID 24679536 DOI: 10.1016/j.cell.2014.02.042  0.8
2014 Stefanovics EA, Krystal JH, Rosenheck RA. Symptom structure and severity: a comparison of responses to the positive and negative syndrome scale (PANSS) between patients with PTSD or schizophrenia. Comprehensive Psychiatry. 55: 887-95. PMID 24602497 DOI: 10.1016/j.comppsych.2014.01.014  0.8
2014 Castellan Baldan L, Williams KA, Gallezot JD, Pogorelov V, Rapanelli M, Crowley M, Anderson GM, Loring E, Gorczyca R, Billingslea E, Wasylink S, Panza KE, Ercan-Sencicek AG, Krusong K, Leventhal BL, ... ... Krystal JH, et al. Histidine decarboxylase deficiency causes tourette syndrome: parallel findings in humans and mice. Neuron. 81: 77-90. PMID 24411733 DOI: 10.1016/j.neuron.2013.10.052  0.8
2014 Leatherman SM, Liang MH, Krystal JH, Lew RA, Valley D, Thwin SS, Rosenheck RA. Differences in treatment effect among clinical subgroups in a randomized clinical trial of long-acting injectable risperidone and oral antipsychotics in unstable chronic schizophrenia. The Journal of Nervous and Mental Disease. 202: 13-7. PMID 24375206 DOI: 10.1097/NMD.0000000000000069  0.8
2014 Anticevic A, Tang Y, Cho YT, Repovs G, Cole MW, Savic A, Wang F, Krystal JH, Xu K. Amygdala connectivity differs among chronic, early course, and individuals at risk for developing schizophrenia. Schizophrenia Bulletin. 40: 1105-16. PMID 24366718 DOI: 10.1093/schbul/sbt165  0.8
2014 Boggs DL, Carlson J, Cortes-Briones J, Krystal JH, D'Souza DC. Going up in smoke? A review of nAChRs-based treatment strategies for improving cognition in schizophrenia. Current Pharmaceutical Design. 20: 5077-92. PMID 24345265 DOI: 10.2174/1381612819666131216121019  0.8
2014 Anticevic A, Hu S, Zhang S, Savic A, Billingslea E, Wasylink S, Repovs G, Cole MW, Bednarski S, Krystal JH, Bloch MH, Li CS, Pittenger C. Global resting-state functional magnetic resonance imaging analysis identifies frontal cortex, striatal, and cerebellar dysconnectivity in obsessive-compulsive disorder. Biological Psychiatry. 75: 595-605. PMID 24314349 DOI: 10.1016/j.biopsych.2013.10.021  0.8
2014 Xie P, Kranzler HR, Krystal JH, Farrer LA, Zhao H, Gelernter J. Deep resequencing of 17 glutamate system genes identifies rare variants in DISC1 and GRIN2B affecting risk of opioid dependence. Addiction Biology. 19: 955-64. PMID 23855403 DOI: 10.1111/adb.12072  0.8
2014 Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, Savic A, Krystal JH, Pearlson GD, Glahn DC. Characterizing thalamo-cortical disturbances in schizophrenia and bipolar illness. Cerebral Cortex (New York, N.Y. : 1991). 24: 3116-30. PMID 23825317 DOI: 10.1093/cercor/bht165  0.8
2014 Murray JD, Anticevic A, Gancsos M, Ichinose M, Corlett PR, Krystal JH, Wang XJ. Linking microcircuit dysfunction to cognitive impairment: effects of disinhibition associated with schizophrenia in a cortical working memory model. Cerebral Cortex (New York, N.Y. : 1991). 24: 859-72. PMID 23203979 DOI: 10.1093/cercor/bhs370  0.8
2013 Anticevic A, Cole MW, Repovs G, Savic A, Driesen NR, Yang G, Cho YT, Murray JD, Glahn DC, Wang XJ, Krystal JH. Connectivity, pharmacology, and computation: toward a mechanistic understanding of neural system dysfunction in schizophrenia. Frontiers in Psychiatry. 4: 169. PMID 24399974 DOI: 10.3389/fpsyt.2013.00169  0.8
2013 Pietrzak RH, Gallezot JD, Ding YS, Henry S, Potenza MN, Southwick SM, Krystal JH, Carson RE, Neumeister A. Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus. Jama Psychiatry. 70: 1199-205. PMID 24048210 DOI: 10.1001/jamapsychiatry.2013.399  0.8
2013 Krystal JH. Biological psychiatry: raising the bar. Biological Psychiatry. 74: 476-7. PMID 24034363 DOI: 10.1016/j.biopsych.2013.07.034  0.8
2013 Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology. 229: 539-54. PMID 23995381 DOI: 10.1007/s00213-013-3226-2  0.8
2013 Zuo L, Wang K, Zhang X, Pan X, Wang G, Krystal JH, Zhang H, Luo X. Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence. Psychiatric Genetics. 23: 233-8. PMID 23907288 DOI: 10.1097/YPG.0b013e328364b8c7  0.8
2013 Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2613-22. PMID 23856634 DOI: 10.1038/npp.2013.170  0.8
2013 Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics and Genomics. 23: 395-402. PMID 23778322 DOI: 10.1097/FPC.0b013e328362f9f2  0.8
2013 Corlett PR, Cambridge V, Gardner JM, Piggot JS, Turner DC, Everitt JC, Arana FS, Morgan HL, Milton AL, Lee JL, Aitken MR, Dickinson A, Everitt BJ, Absalom AR, Adapa R, ... ... Krystal JH, et al. Ketamine effects on memory reconsolidation favor a learning model of delusions. Plos One. 8: e65088. PMID 23776445 DOI: 10.1371/journal.pone.0065088  0.8
2013 Zuo L, Saba L, Wang K, Zhang X, Krystal JH, Tabakoff B, Luo X. Exome-wide association study of replicable nonsynonymous variants conferring risk for alcohol dependence. Journal of Studies On Alcohol and Drugs. 74: 622-5. PMID 23739027  0.8
2013 Krystal JH, Sanacora G, Duman RS. Rapid-acting glutamatergic antidepressants: the path to ketamine and beyond. Biological Psychiatry. 73: 1133-41. PMID 23726151 DOI: 10.1016/j.biopsych.2013.03.026  0.8
2013 DeVito EE, Meda SA, Jiantonio R, Potenza MN, Krystal JH, Pearlson GD. Neural correlates of impulsivity in healthy males and females with family histories of alcoholism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 1854-63. PMID 23584260 DOI: 10.1038/npp.2013.92  0.8
2013 Jiang L, Gulanski BI, De Feyter HM, Weinzimer SA, Pittman B, Guidone E, Koretski J, Harman S, Petrakis IL, Krystal JH, Mason GF. Increased brain uptake and oxidation of acetate in heavy drinkers. The Journal of Clinical Investigation. 123: 1605-14. PMID 23478412 DOI: 10.1172/JCI65153  0.8
2013 Zuo L, Wang K, Zhang XY, Pan X, Wang G, Tan Y, Zhong C, Krystal JH, State M, Zhang H, Luo X. Association between common alcohol dehydrogenase gene (ADH) variants and schizophrenia and autism. Human Genetics. 132: 735-43. PMID 23468174 DOI: 10.1007/s00439-013-1277-4  0.8
2013 Zuo L, Wang K, Zhang XY, Krystal JH, Li CS, Zhang F, Zhang H, Luo X. NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent. Drug and Alcohol Dependence. 129: 254-64. PMID 23455491 DOI: 10.1016/j.drugalcdep.2013.02.006  0.8
2013 Gueorguieva R, Wu R, Krystal JH, Donovan D, O'Malley SS. Temporal patterns of adherence to medications and behavioral treatment and their relationship to patient characteristics and treatment response. Addictive Behaviors. 38: 2119-27. PMID 23435273 DOI: 10.1016/j.addbeh.2013.01.024  0.8
2013 Narayanan B, Stevens MC, Jiantonio RE, Krystal JH, Pearlson GD. Effects of memantine on event-related potential, oscillations, and complexity in individuals with and without family histories of alcoholism. Journal of Studies On Alcohol and Drugs. 74: 245-57. PMID 23384372  0.8
2013 Driesen NR, McCarthy G, Bhagwagar Z, Bloch M, Calhoun V, D'Souza DC, Gueorguieva R, He G, Ramachandran R, Suckow RF, Anticevic A, Morgan PT, Krystal JH. Relationship of resting brain hyperconnectivity and schizophrenia-like symptoms produced by the NMDA receptor antagonist ketamine in humans. Molecular Psychiatry. 18: 1199-204. PMID 23337947 DOI: 10.1038/mp.2012.194  0.8
2013 Zuo L, Zhang XY, Wang F, Li CS, Lu L, Ye L, Zhang H, Krystal JH, Deng HW, Luo X. Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence. Alcoholism, Clinical and Experimental Research. 37: 730-9. PMID 23216389 DOI: 10.1111/acer.12032  0.8
2013 Fryer SL, Jorgensen KW, Yetter EJ, Daurignac EC, Watson TD, Shanbhag H, Krystal JH, Mathalon DH. Differential brain response to alcohol cue distractors across stages of alcohol dependence. Biological Psychology. 92: 282-91. PMID 23131612 DOI: 10.1016/j.biopsycho.2012.10.004  0.8
2013 Woods SW, Walsh BC, Hawkins KA, Miller TJ, Saksa JR, D'Souza DC, Pearlson GD, Javitt DC, McGlashan TH, Krystal JH. Glycine treatment of the risk syndrome for psychosis: report of two pilot studies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 931-40. PMID 23089076 DOI: 10.1016/j.euroneuro.2012.09.008  0.8
2013 Zuo L, Zhang H, Malison RT, Li CS, Zhang XY, Wang F, Lu L, Lu L, Wang X, Krystal JH, Zhang F, Deng HW, Luo X. Rare ADH variant constellations are specific for alcohol dependence. Alcohol and Alcoholism (Oxford, Oxfordshire). 48: 9-14. PMID 23019235 DOI: 10.1093/alcalc/ags104  0.8
2013 Anticevic A, Brumbaugh MS, Winkler AM, Lombardo LE, Barrett J, Corlett PR, Kober H, Gruber J, Repovs G, Cole MW, Krystal JH, Pearlson GD, Glahn DC. Global prefrontal and fronto-amygdala dysconnectivity in bipolar I disorder with psychosis history. Biological Psychiatry. 73: 565-73. PMID 22980587 DOI: 10.1016/j.biopsych.2012.07.031  0.8
2013 Pietrzak RH, Henry S, Southwick SM, Krystal JH, Neumeister A. Linking in vivo brain serotonin type 1B receptor density to phenotypic heterogeneity of posttraumatic stress symptomatology. Molecular Psychiatry. 18: 399-401. PMID 22584868 DOI: 10.1038/mp.2012.60  0.8
2012 Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends in Cognitive Sciences. 16: 584-92. PMID 23142417 DOI: 10.1016/j.tics.2012.10.008  0.8
2012 Anticevic A, Gancsos M, Murray JD, Repovs G, Driesen NR, Ennis DJ, Niciu MJ, Morgan PT, Surti TS, Bloch MH, Ramani R, Smith MA, Wang XJ, Krystal JH, Corlett PR. NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia. Proceedings of the National Academy of Sciences of the United States of America. 109: 16720-5. PMID 23012427 DOI: 10.1073/pnas.1208494109  0.8
2012 Moghaddam B, Krystal JH. Capturing the angel in "angel dust": twenty years of translational neuroscience studies of NMDA receptor antagonists in animals and humans. Schizophrenia Bulletin. 38: 942-9. PMID 22899397 DOI: 10.1093/schbul/sbs075  0.8
2012 Anticevic A, Repovs G, Krystal JH, Barch DM. A broken filter: prefrontal functional connectivity abnormalities in schizophrenia during working memory interference. Schizophrenia Research. 141: 8-14. PMID 22863548 DOI: 10.1016/j.schres.2012.07.007  0.8
2012 Bloch MH, Wasylink S, Landeros-Weisenberger A, Panza KE, Billingslea E, Leckman JF, Krystal JH, Bhagwagar Z, Sanacora G, Pittenger C. Effects of ketamine in treatment-refractory obsessive-compulsive disorder. Biological Psychiatry. 72: 964-70. PMID 22784486 DOI: 10.1016/j.biopsych.2012.05.028  0.8
2012 Barnett PG, Scott JY, Krystal JH, Rosenheck RA. Cost and cost-effectiveness in a randomized trial of long-acting risperidone for schizophrenia. The Journal of Clinical Psychiatry. 73: 696-702. PMID 22697193 DOI: 10.4088/JCP.11m07070  0.8
2012 Nestler EJ, Krystal JH. Planning the new national institute on substance use and addiction disorders. Biological Psychiatry. 72: 166-7. PMID 22683089 DOI: 10.1016/j.biopsych.2012.05.011  0.8
2012 Hyatt CJ, Assaf M, Muska CE, Rosen RI, Thomas AD, Johnson MR, Hylton JL, Andrews MM, Reynolds BA, Krystal JH, Potenza MN, Pearlson GD. Reward-related dorsal striatal activity differences between former and current cocaine dependent individuals during an interactive competitive game. Plos One. 7: e34917. PMID 22606228 DOI: 10.1371/journal.pone.0034917  0.8
2012 Krystal JH. Enhancing prolonged exposure therapy for posttraumatic stress disorder with D-cycloserine: further support for treatments that promote experience-dependent neuroplasticity. Biological Psychiatry. 71: 932-4. PMID 22579302 DOI: 10.1016/j.biopsych.2012.03.031  0.8
2012 Zuo L, Zhang F, Zhang H, Zhang XY, Wang F, Li CSR, Lu L, Hong J, Krystal J, Deng HW, Luo X. Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 159: 437-444. PMID 22488850 DOI: 10.1002/ajmg.b.32047  0.8
2012 Cavu? I, Reinhart RM, Roach BJ, Gueorguieva R, Teyler TJ, Clapp WC, Ford JM, Krystal JH, Mathalon DH. Impaired visual cortical plasticity in schizophrenia. Biological Psychiatry. 71: 512-20. PMID 22364738 DOI: 10.1016/j.biopsych.2012.01.013  0.8
2012 Pietrzak RH, Maruff P, Woodward M, Fredrickson J, Fredrickson A, Krystal JH, Southwick SM, Darby D. Mild worry symptoms predict decline in learning and memory in healthy older adults: a 2-year prospective cohort study. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 20: 266-75. PMID 22354117 DOI: 10.1097/JGP.0b013e3182107e24  0.8
2012 Jamadar S, DeVito EE, Jiantonio RE, Meda SA, Stevens MC, Potenza MN, Krystal JH, Pearlson GD. Memantine, an NMDA receptor antagonist, differentially influences Go/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism. Psychopharmacology. 222: 129-40. PMID 22311382 DOI: 10.1007/s00213-011-2628-2  0.8
2012 Stone JM, Dietrich C, Edden R, Mehta MA, De Simoni S, Reed LJ, Krystal JH, Nutt D, Barker GJ. Ketamine effects on brain GABA and glutamate levels with 1H-MRS: relationship to ketamine-induced psychopathology. Molecular Psychiatry. 17: 664-5. PMID 22212598 DOI: 10.1038/mp.2011.171  0.8
2012 Steine IM, Krystal JH, Nordhus IH, Bjorvatn B, Harvey AG, Eid J, Grønli J, Milde AM, Pallesen S. Insomnia, nightmare frequency, and nightmare distress in victims of sexual abuse: the role of perceived social support and abuse characteristics. Journal of Interpersonal Violence. 27: 1827-43. PMID 22204947 DOI: 10.1177/0886260511430385  0.8
2012 Petrakis IL, Ralevski E, Desai N, Trevisan L, Gueorguieva R, Rounsaville B, Krystal JH. Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 996-1004. PMID 22089316 DOI: 10.1038/npp.2011.283  0.8
2012 Urban NB, Slifstein M, Meda S, Xu X, Ayoub R, Medina O, Pearlson GD, Krystal JH, Abi-Dargham A. Imaging human reward processing with positron emission tomography and functional magnetic resonance imaging. Psychopharmacology. 221: 67-77. PMID 22052081 DOI: 10.1007/s00213-011-2543-6  0.8
2012 Gunduz-Bruce H, Reinhart RM, Roach BJ, Gueorguieva R, Oliver S, D'Souza DC, Ford JM, Krystal JH, Mathalon DH. Glutamatergic modulation of auditory information processing in the human brain. Biological Psychiatry. 71: 969-77. PMID 22036036 DOI: 10.1016/j.biopsych.2011.09.031  0.8
2012 Zuo L, Gelernter J, Zhang CK, Zhao H, Lu L, Kranzler HR, Malison RT, Li CS, Wang F, Zhang XY, Deng HW, Krystal JH, Zhang F, Luo X. Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 557-66. PMID 21956439 DOI: 10.1038/npp.2011.229  0.8
2012 Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O'Malley SS. Baseline trajectories of heavy drinking and their effects on postrandomization drinking in the COMBINE Study: empirically derived predictors of drinking outcomes during treatment. Alcohol (Fayetteville, N.Y.). 46: 121-31. PMID 21925828 DOI: 10.1016/j.alcohol.2011.08.008  0.8
2012 Gomez R, Behar KL, Watzl J, Weinzimer SA, Gulanski B, Sanacora G, Koretski J, Guidone E, Jiang L, Petrakis IL, Pittman B, Krystal JH, Mason GF. Intravenous ethanol infusion decreases human cortical γ-aminobutyric acid and N-acetylaspartate as measured with proton magnetic resonance spectroscopy at 4 tesla. Biological Psychiatry. 71: 239-46. PMID 21855054 DOI: 10.1016/j.biopsych.2011.06.026  0.8
2012 Steine IM, Harvey AG, Krystal JH, Milde AM, Grønli J, Bjorvatn B, Nordhus IH, Eid J, Pallesen S. Sleep disturbances in sexual abuse victims: a systematic review. Sleep Medicine Reviews. 16: 15-25. PMID 21600813 DOI: 10.1016/j.smrv.2011.01.006  0.8
2011 Gueorguieva R, Mallinckrodt C, Krystal JH. Trajectories of depression severity in clinical trials of duloxetine: insights into antidepressant and placebo responses. Archives of General Psychiatry. 68: 1227-37. PMID 22147842 DOI: 10.1001/archgenpsychiatry.2011.132  0.8
2011 Zuo L, Zhang CK, Wang F, Li CS, Zhao H, Lu L, Zhang XY, Lu L, Zhang H, Zhang F, Krystal JH, Luo X. A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. Plos One. 6: e26726. PMID 22096494 DOI: 10.1371/journal.pone.0026726  0.8
2011 Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, ... ... Krystal JH, et al. Advancing drug discovery for schizophrenia. Annals of the New York Academy of Sciences. 1236: 30-43. PMID 22032400 DOI: 10.1111/j.1749-6632.2011.06216.x  0.8
2011 Murrough JW, Czermak C, Henry S, Nabulsi N, Gallezot JD, Gueorguieva R, Planeta-Wilson B, Krystal JH, Neumaier JF, Huang Y, Ding YS, Carson RE, Neumeister A. The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding. Archives of General Psychiatry. 68: 892-900. PMID 21893657 DOI: 10.1001/archgenpsychiatry.2011.91  0.8
2011 Murrough JW, Huang Y, Hu J, Henry S, Williams W, Gallezot JD, Bailey CR, Krystal JH, Carson RE, Neumeister A. Reduced amygdala serotonin transporter binding in posttraumatic stress disorder. Biological Psychiatry. 70: 1033-8. PMID 21855859 DOI: 10.1016/j.biopsych.2011.07.003  0.8
2011 Krystal JH, Rosenheck RA, Cramer JA, Vessicchio JC, Jones KM, Vertrees JE, Horney RA, Huang GD, Stock C. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. Jama. 306: 493-502. PMID 21813427 DOI: 10.1001/jama.2011.1080  0.8
2011 Xie P, Kranzler HR, Krauthammer M, Cosgrove KP, Oslin D, Anton RF, Farrer LA, Picciotto MR, Krystal JH, Zhao H, Gelernter J. Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence. Biological Psychiatry. 70: 528-36. PMID 21683344 DOI: 10.1016/j.biopsych.2011.04.017  0.8
2011 Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, et al. Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders. Biological Psychiatry. 70: 7-12. PMID 21529781 DOI: 10.1016/j.biopsych.2011.01.041  0.8
2011 Soyka M, Kranzler HR, van den Brink W, Krystal J, Möller HJ, Kasper S. The World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the biological treatment of substance use and related disorders. Part 2: Opioid dependence. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 12: 160-87. PMID 21486104 DOI: 10.3109/15622975.2011.561872  0.8
2011 Rosenheck RA, Krystal JH, Lew R, Barnett PG, Fiore L, Valley D, Thwin SS, Vertrees JE, Liang MH. Long-acting risperidone and oral antipsychotics in unstable schizophrenia. The New England Journal of Medicine. 364: 842-51. PMID 21366475 DOI: 10.1056/NEJMoa1005987  0.8
2011 Freeman WM, Vanguilder HD, Guidone E, Krystal JH, Grant KA, Vrana KE. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 899-911. PMID 21303580 DOI: 10.1017/S1461145711000046  0.8
2011 Cosgrove KP, Esterlis I, Mason GF, Bois F, O'Malley SS, Krystal JH. Neuroimaging insights into the role of cortical GABA systems and the influence of nicotine on the recovery from alcohol dependence. Neuropharmacology. 60: 1318-25. PMID 21276806 DOI: 10.1016/j.neuropharm.2011.01.020  0.8
2011 Rosenheck RA, Krystal JH, Lew R, Barnett PG, Thwin SS, Fiore L, Valley D, Huang GD, Neal C, Vertrees JE, Liang MH. Challenges in the design and conduct of controlled clinical effectiveness trials in schizophrenia. Clinical Trials (London, England). 8: 196-204. PMID 21270143 DOI: 10.1177/1740774510392931  0.8
2011 Valentine GW, Mason GF, Gomez R, Fasula M, Watzl J, Pittman B, Krystal JH, Sanacora G. The antidepressant effect of ketamine is not associated with changes in occipital amino acid neurotransmitter content as measured by [(1)H]-MRS. Psychiatry Research. 191: 122-7. PMID 21232924 DOI: 10.1016/j.pscychresns.2010.10.009  0.8
2011 Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O'Malley SS. Baseline trajectories of drinking moderate acamprosate and naltrexone effects in the COMBINE study. Alcoholism, Clinical and Experimental Research. 35: 523-31. PMID 21143249 DOI: 10.1111/j.1530-0277.2010.01369.x  0.8
2011 Andrews MM, Meda SA, Thomas AD, Potenza MN, Krystal JH, Worhunsky P, Stevens MC, O'Malley S, Book GA, Reynolds B, Pearlson GD. Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors. Biological Psychiatry. 69: 675-83. PMID 21126735 DOI: 10.1016/j.biopsych.2010.09.049  0.8
2011 Krystal JH, Petrakis IL, Limoncelli D, Nappi SK, Trevisan L, Pittman B, D'Souza DC, Suckow RF. Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 701-10. PMID 21124304 DOI: 10.1038/npp.2010.203  0.8
2011 Hallak JE, Dursun SM, Bosi DC, de Macedo LR, Machado-de-Sousa JP, Abrão J, Crippa JA, McGuire P, Krystal JH, Baker GB, Zuardi AW. The interplay of cannabinoid and NMDA glutamate receptor systems in humans: preliminary evidence of interactive effects of cannabidiol and ketamine in healthy human subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35: 198-202. PMID 21062637 DOI: 10.1016/j.pnpbp.2010.11.002  0.8
2011 Corlett PR, Honey GD, Krystal JH, Fletcher PC. Glutamatergic model psychoses: prediction error, learning, and inference. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 294-315. PMID 20861831 DOI: 10.1038/npp.2010.163  0.8
2011 Krystal JH. Biological psychiatry: A time of opportunity, a time of challenge Biological Psychiatry. 70: 3-4. DOI: 10.1016/j.biopsych.2011.04.020  0.8
2011 Krystal JH, Moghaddam B. Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia Schizophrenia: Third Edition. 433-461. DOI: 10.1002/9781444327298.ch21  0.8
2011 Rosenheck RA, Krystal JH. The authors reply New England Journal of Medicine. 364: 2265-2266.  0.8
2010 Krystal JH. N-methyl-D-aspartate glutamate receptor antagonists and the promise of rapid-acting antidepressants. Archives of General Psychiatry. 67: 1110-1. PMID 21041611 DOI: 10.1001/archgenpsychiatry.2010.138  0.8
2010 Sewell RA, Perry EB, Karper LP, Bell MD, Lysaker P, Goulet JL, Brenner L, Erdos J, d'Souza DC, Seibyl JP, Krystal JH. Clinical significance of neurological soft signs in schizophrenia: factor analysis of the Neurological Evaluation Scale. Schizophrenia Research. 124: 1-12. PMID 20855185 DOI: 10.1016/j.schres.2010.08.036  0.8
2010 Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex differences in striatal dopamine release in young adults after oral alcohol challenge: a positron emission tomography imaging study with [¹¹C]raclopride. Biological Psychiatry. 68: 689-96. PMID 20678752 DOI: 10.1016/j.biopsych.2010.06.005  0.8
2010 Krystal JH, Mathew SJ, D'Souza DC, Garakani A, Gunduz-Bruce H, Charney DS. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. Cns Drugs. 24: 669-93. PMID 20658799 DOI: 10.2165/11533230-000000000-00000  0.8
2010 Corlett PR, Taylor JR, Wang XJ, Fletcher PC, Krystal JH. Toward a neurobiology of delusions. Progress in Neurobiology. 92: 345-69. PMID 20558235 DOI: 10.1016/j.pneurobio.2010.06.007  0.8
2010 Yun RJ, Krystal JH, Mathalon DH. Working memory overload: fronto-limbic interactions and effects on subsequent working memory function. Brain Imaging and Behavior. 4: 96-108. PMID 20503117 DOI: 10.1007/s11682-010-9089-9  0.8
2010 Corlett PR, D'Souza DC, Krystal JH. Capgras syndrome induced by ketamine in a healthy subject. Biological Psychiatry. 68: e1-2. PMID 20385373 DOI: 10.1016/j.biopsych.2010.02.015  0.8
2010 Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. A prospective cohort study investigating factors associated with depression during medical internship. Archives of General Psychiatry. 67: 557-65. PMID 20368500 DOI: 10.1001/archgenpsychiatry.2010.41  0.8
2010 Cosgrove KP, Kloczynski T, Bois F, Pittman B, Tamagnan G, Seibyl JP, Krystal JH, Staley JK. Decreased Beta(2)*-nicotinic acetylcholine receptor availability after chronic ethanol exposure in nonhuman primates. Synapse (New York, N.Y.). 64: 729-32. PMID 20340174 DOI: 10.1002/syn.20795  0.8
2010 Hu J, Henry S, Gallezot JD, Ropchan J, Neumaier JF, Potenza MN, Sinha R, Krystal JH, Huang Y, Ding YS, Carson RE, Neumeister A. Serotonin 1B receptor imaging in alcohol dependence. Biological Psychiatry. 67: 800-3. PMID 20172504 DOI: 10.1016/j.biopsych.2009.12.028  0.8
2010 Aikins DE, Anticevic A, Kiehl KA, Krystal JH. Sex-related differences in amygdala activity influences immediate memory. Neuroreport. 21: 273-6. PMID 20093991 DOI: 10.1097/WNR.0b013e328335b3f9  0.8
2010 Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug and Alcohol Dependence. 108: 146-50. PMID 20074869 DOI: 10.1016/j.drugalcdep.2009.12.006  0.8
2010 Gueorguieva R, Wu R, Donovan D, Rounsaville BJ, Couper D, Krystal JH, O'Malley SS. Naltrexone and combined behavioral intervention effects on trajectories of drinking in the COMBINE study. Drug and Alcohol Dependence. 107: 221-9. PMID 19969427 DOI: 10.1016/j.drugalcdep.2009.10.017  0.8
2010 Otto MW, Tolin DF, Simon NM, Pearlson GD, Basden S, Meunier SA, Hofmann SG, Eisenmenger K, Krystal JH, Pollack MH. Efficacy of d-cycloserine for enhancing response to cognitive-behavior therapy for panic disorder. Biological Psychiatry. 67: 365-70. PMID 19811776 DOI: 10.1016/j.biopsych.2009.07.036  0.8
2010 Landeros-Weisenberger A, Bloch MH, Kelmendi B, Wegner R, Nudel J, Dombrowski P, Pittenger C, Krystal JH, Goodman WK, Leckman JF, Coric V. Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. Journal of Affective Disorders. 121: 175-9. PMID 19577308 DOI: 10.1016/j.jad.2009.06.010  0.8
2010 Dickerson D, Pittman B, Ralevski E, Perrino A, Limoncelli D, Edgecombe J, Acampora G, Krystal JH, Petrakis I. Ethanol-like effects of thiopental and ketamine in healthy humans. Journal of Psychopharmacology (Oxford, England). 24: 203-11. PMID 19028835 DOI: 10.1177/0269881108098612  0.8
2010 Nakic M, Krystal JH, Bhagwagar Z. Neurotransmitter Systems in Bipolar Disorder Bipolar Disorder: Clinical and Neurobiological Foundations. 210-227. DOI: 10.1002/9780470661277.ch16  0.8
2010 Sen S, Kranzler HR, Krystal JH, Speller H, Chan G, Gelernter J, Guille C. In reply Archives of General Psychiatry. 67: 568-569. DOI: 10.1001/archgenpsychiatry.2010.53  0.8
2010 Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target of the pharmacotherapy of anxiety disorders, mood disorders and schizophrenia | Neuroplastyczność jako cel dla farmakoterapii zaburzeń lȩkowych, zaburzeń nastroju i schizofrenii Wiadomosci Psychiatryczne. 13: 163-173.  0.8
2009 Krystal JH. The evolution of the psychiatry research journal. The Journal of Clinical Psychiatry. 70: 1601-2. PMID 20031103 DOI: 10.4088/JCP.09com05629whi  0.8
2009 Corlett PR, Simons JS, Pigott JS, Gardner JM, Murray GK, Krystal JH, Fletcher PC. Illusions and delusions: relating experimentally-induced false memories to anomalous experiences and ideas. Frontiers in Behavioral Neuroscience. 3: 53. PMID 19956402 DOI: 10.3389/neuro.08.053.2009  0.8
2009 Corlett PR, Krystal JH, Taylor JR, Fletcher PC. Why do delusions persist? Frontiers in Human Neuroscience. 3: 12. PMID 19636384 DOI: 10.3389/neuro.09.012.2009  0.8
2009 Krystal JH, Tolin DF, Sanacora G, Castner SA, Williams GV, Aikins DE, Hoffman RE, D'Souza DC. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Drug Discovery Today. 14: 690-7. PMID 19460458 DOI: 10.1016/j.drudis.2009.05.002  0.8
2009 Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS, Staley JK. Dopamine and serotonin transporter availability during acute alcohol withdrawal: effects of comorbid tobacco smoking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2218-26. PMID 19440191 DOI: 10.1038/npp.2009.49  0.8
2009 Zuo L, Luo X, Krystal JH, Cramer J, Charney DS, Gelernter J. The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation. Pharmacogenetics and Genomics. 19: 437-46. PMID 19369910 DOI: 10.1097/FPC.0b013e32832b9cfc  0.8
2009 Krystal JH, Neumeister A. Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. Brain Research. 1293: 13-23. PMID 19332037 DOI: 10.1016/j.brainres.2009.03.044  0.8
2009 Zuo L, Luo X, Listman JB, Kranzler HR, Wang S, Anton RF, Blumberg HP, Stein MB, Pearlson GD, Covault J, Charney DS, van Kammen DP, Price LH, Lappalainen J, Cramer J, ... Krystal JH, et al. Population admixture modulates risk for alcohol dependence. Human Genetics. 125: 605-13. PMID 19306106 DOI: 10.1007/s00439-009-0647-4  0.8
2009 Barch DM, Carter CS, Arnsten A, Buchanan RW, Cohen JD, Geyer M, Green MF, Krystal JH, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophrenia Bulletin. 35: 109-14. PMID 19023126 DOI: 10.1093/schbul/sbn163  0.8
2009 Weder N, Yang BZ, Douglas-Palumberi H, Massey J, Krystal JH, Gelernter J, Kaufman J. MAOA genotype, maltreatment, and aggressive behavior: the changing impact of genotype at varying levels of trauma. Biological Psychiatry. 65: 417-24. PMID 18996506 DOI: 10.1016/j.biopsych.2008.09.013  0.8
2009 Watson TD, Petrakis IL, Edgecombe J, Perrino A, Krystal JH, Mathalon DH. Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 357-70. PMID 18771605 DOI: 10.1017/S1461145708009334  0.8
2009 Krystal JH. Biological Psychiatry: Real Progress Biological Psychiatry. 65: 3-4. DOI: 10.1016/j.biopsych.2008.08.026  0.8
2008 Krishnan-Sarin S, O'Malley S, Krystal JH. Treatment implications: using neuroscience to guide the development of new pharmacotherapies for alcoholism. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 31: 400-7. PMID 23584013  0.8
2008 Perepletchikova F, Krystal JH, Kaufman J. Practitioner review: adolescent alcohol use disorders: assessment and treatment issues. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 49: 1131-54. PMID 19017028 DOI: 10.1111/j.1469-7610.2008.01934.x  0.8
2008 Driesen NR, Leung HC, Calhoun VD, Constable RT, Gueorguieva R, Hoffman R, Skudlarski P, Goldman-Rakic PS, Krystal JH. Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. Biological Psychiatry. 64: 1026-34. PMID 18823880 DOI: 10.1016/j.biopsych.2008.07.029  0.8
2008 Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the treatment of mood and anxiety disorders. Cns Drugs. 22: 761-86. PMID 18698875 DOI: 10.2165/00023210-200822090-00004  0.8
2008 Krystal JH. Capitalizing on extrasynaptic glutamate neurotransmission to treat antipsychotic-resistant symptoms in schizophrenia. Biological Psychiatry. 64: 358-60. PMID 18694665 DOI: 10.1016/j.biopsych.2008.06.011  0.8
2008 Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH, Cohen J, Geyer M, Green M, Nuechterlein KH, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biological Psychiatry. 64: 4-10. PMID 18466880 DOI: 10.1016/j.biopsych.2008.03.020  0.8
2008 Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews. Drug Discovery. 7: 426-37. PMID 18425072 DOI: 10.1038/nrd2462  0.8
2008 Cavus I, Pan JW, Hetherington HP, Abi-Saab W, Zaveri HP, Vives KP, Krystal JH, Spencer SS, Spencer DD. Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients. Epilepsia. 49: 1358-66. PMID 18410365 DOI: 10.1111/j.1528-1167.2008.01603.x  0.8
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  0.8
2008 Norberg MM, Krystal JH, Tolin DF. A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biological Psychiatry. 63: 1118-26. PMID 18313643 DOI: 10.1016/j.biopsych.2008.01.012  0.8
2008 Jackowski AP, Douglas-Palumberi H, Jackowski M, Win L, Schultz RT, Staib LW, Krystal JH, Kaufman J. Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study. Psychiatry Research. 162: 256-61. PMID 18296031 DOI: 10.1016/j.pscychresns.2007.08.006  0.8
2008 Czermak C, Staley JK, Kasserman S, Bois F, Young T, Henry S, Tamagnan GD, Seibyl JP, Krystal JH, Neumeister A. beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 11: 419-24. PMID 18190729 DOI: 10.1017/S1461145707008152  0.8
2008 Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS. Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study. Psychopharmacology. 197: 401-8. PMID 18176855 DOI: 10.1007/s00213-007-1047-x  0.8
2008 Krystal JH, Gueorguieva R, Cramer J, Collins J, Rosenheck R. Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism". Alcoholism, Clinical and Experimental Research. 32: 85-91. PMID 18070245 DOI: 10.1111/j.1530-0277.2007.00555.x  0.8
2008 Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D'Souza DC, Perry E, Limoncelli D, Krystal JH. Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors. Alcoholism, Clinical and Experimental Research. 32: 36-42. PMID 18028532 DOI: 10.1111/j.1530-0277.2007.00543.x  0.8
2007 Goff DC, Keefe R, Citrome L, Davy K, Krystal JH, Large C, Thompson TR, Volavka J, Webster EL. Lamotrigine as add-on therapy in schizophrenia: results of 2 placebo-controlled trials. Journal of Clinical Psychopharmacology. 27: 582-9. PMID 18004124 DOI: 10.1097/jcp.0b013e31815abf34  0.8
2007 Krystal JH. Neuroplasticity as a target for the pharmacotherapy of psychiatric disorders: new opportunities for synergy with psychotherapy. Biological Psychiatry. 62: 833-4. PMID 17916459 DOI: 10.1016/j.biopsych.2007.08.017  0.8
2007 Ford JM, Krystal JH, Mathalon DH. Neural synchrony in schizophrenia: from networks to new treatments. Schizophrenia Bulletin. 33: 848-52. PMID 17567628 DOI: 10.1093/schbul/sbm062  0.8
2007 Krystal JH. Ketamine and the potential role for rapid-acting antidepressant medications. Swiss Medical Weekly. 137: 215-6. PMID 17525875  0.8
2007 McDougle CJ, Krystal JH. Pediatric psychopharmacology: mood, anxiety and disruptive behavior/pervasive developmental disorders. Psychopharmacology. 191: 1-3. PMID 17476481 DOI: 10.1007/s00213-007-0720-4  0.8
2007 Perry EB, Cramer JA, Cho HS, Petrakis IL, Karper LP, Genovese A, O'Donnell E, Krystal JH, D'Souza DC. Psychiatric safety of ketamine in psychopharmacology research. Psychopharmacology. 192: 253-60. PMID 17458544 DOI: 10.1007/s00213-007-0706-2  0.8
2007 Pittenger C, Sanacora G, Krystal JH. The NMDA receptor as a therapeutic target in major depressive disorder. Cns & Neurological Disorders Drug Targets. 6: 101-15. PMID 17430148 DOI: 10.2174/187152707780363267  0.8
2007 Pittman B, Gueorguieva R, Krupitsky E, Rudenko AA, Flannery BA, Krystal JH. Multidimensionality of the Alcohol Withdrawal Symptom Checklist: a factor analysis of the Alcohol Withdrawal Symptom Checklist and CIWA-Ar. Alcoholism, Clinical and Experimental Research. 31: 612-8. PMID 17374040 DOI: 10.1111/j.1530-0277.2007.00345.x  0.8
2007 Krupitsky EM, Rudenko AA, Burakov AM, Slavina TY, Grinenko AA, Pittman B, Gueorguieva R, Petrakis IL, Zvartau EE, Krystal JH. Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam. Alcoholism, Clinical and Experimental Research. 31: 604-11. PMID 17374039 DOI: 10.1111/j.1530-0277.2007.00344.x  0.8
2007 Gelernter J, Gueorguieva R, Kranzler HR, Zhang H, Cramer J, Rosenheck R, Krystal JH. Opioid receptor gene (OPRM1, OPRK1, and OPRD1) variants and response to naltrexone treatment for alcohol dependence: results from the VA Cooperative Study. Alcoholism, Clinical and Experimental Research. 31: 555-63. PMID 17374034 DOI: 10.1111/j.1530-0277.2007.00339.x  0.8
2007 Krishnan-Sarin S, Krystal JH, Shi J, Pittman B, O'Malley SS. Family history of alcoholism influences naltrexone-induced reduction in alcohol drinking. Biological Psychiatry. 62: 694-7. PMID 17336941 DOI: 10.1016/j.biopsych.2006.11.018  0.8
2007 Krupitsky EM, Neznanova O, Masalov D, Burakov AM, Didenko T, Romanova T, Tsoy M, Bespalov A, Slavina TY, Grinenko AA, Petrakis IL, Pittman B, Gueorguieva R, Zvartau EE, Krystal JH. Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients. The American Journal of Psychiatry. 164: 519-23. PMID 17329479 DOI: 10.1176/appi.ajp.164.3.519  0.8
2007 Epperson CN, Pittman B, Czarkowski KA, Stiklus S, Krystal JH, Grillon C. Luteal-phase accentuation of acoustic startle response in women with premenstrual dysphoric disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2190-8. PMID 17314917 DOI: 10.1038/sj.npp.1301351  0.8
2007 Hoffman RE, Hampson M, Wu K, Anderson AW, Gore JC, Buchanan RJ, Constable RT, Hawkins KA, Sahay N, Krystal JH. Probing the pathophysiology of auditory/verbal hallucinations by combining functional magnetic resonance imaging and transcranial magnetic stimulation. Cerebral Cortex (New York, N.Y. : 1991). 17: 2733-43. PMID 17298962 DOI: 10.1093/cercor/bhl183  0.8
2007 Gueorguieva R, Wu R, Pittman B, Cramer J, Rosenheck RA, O'malley SS, Krystal JH. New insights into the efficacy of naltrexone based on trajectory-based reanalyses of two negative clinical trials. Biological Psychiatry. 61: 1290-5. PMID 17224132 DOI: 10.1016/j.biopsych.2006.09.038  0.8
2007 Sanacora G, Kendell SF, Levin Y, Simen AA, Fenton LR, Coric V, Krystal JH. Preliminary evidence of riluzole efficacy in antidepressant-treated patients with residual depressive symptoms. Biological Psychiatry. 61: 822-5. PMID 17141740 DOI: 10.1016/j.biopsych.2006.08.037  0.8
2007 Kaufman J, Yang BZ, Douglas-Palumberi H, Crouse-Artus M, Lipschitz D, Krystal JH, Gelernter J. Genetic and environmental predictors of early alcohol use. Biological Psychiatry. 61: 1228-34. PMID 17123474 DOI: 10.1016/j.biopsych.2006.06.039  0.8
2007 Lappalainen J, Krupitsky E, Kranzler HR, Luo X, Remizov M, Pchelina S, Taraskina A, Zvartau E, Räsanen P, Makikyro T, Somberg LK, Krystal JH, Stein MB, Gelernter J. Mutation screen of the GAD2 gene and association study of alcoholism in three populations. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 183-92. PMID 17034009 DOI: 10.1002/ajmg.b.30377  0.8
2007 Epperson CN, Amin Z, Naftolin F, Cappiello A, Czarkowski KA, Stiklus S, Anderson GM, Krystal JH. The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings. Journal of Psychopharmacology (Oxford, England). 21: 414-20. PMID 16891341 DOI: 10.1177/0269881106067330  0.8
2007 Krystal JH. Biological Psychiatry: Increasing Impact Biological Psychiatry. 62: 1203-1204. DOI: 10.1016/j.biopsych.2007.09.021  0.8
2007 Heninger GR, Krystal JH, Duman RS, Bunney BS, Bowers MB, Aghajanian GK. The Neuroscience Research Program at the Connecticut Mental Health Center 40 Years of Academic Public Psychiatry. 77-95. DOI: 10.1002/9780470994580.ch4  0.8
2006 Krystal JH, D'Souza DC, Gallinat J, Driesen N, Abi-Dargham A, Petrakis I, Heinz A, Pearlson G. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Neurotoxicity Research. 10: 235-52. PMID 17197373 DOI: 10.1007/BF03033360  0.8
2006 Sasso DA, Kalanithi PS, Trueblood KV, Pittenger C, Kelmendi B, Wayslink S, Malison RT, Krystal JH, Coric V. Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors. Journal of Clinical Psychopharmacology. 26: 685-7. PMID 17110840 DOI: 10.1097/01.jcp.0000245567.29531.d6  0.8
2006 Neumeister A, Carson R, Henry S, Planeta-Wilson B, Binneman B, Maguire RP, Luckenbaugh DA, D'Souza C, Krystal JH, Frost JJ. Cerebral metabolic effects of intravenous glycine in healthy human subjects. Journal of Clinical Psychopharmacology. 26: 595-9. PMID 17110816 DOI: 10.1097/01.jcp.0000245558.14284.aa  0.8
2006 Krystal JH. Biological psychiatry: A new leadership team. Biological Psychiatry. 60: 794-5. PMID 17045860 DOI: 10.1016/j.biopsych.2006.09.004  0.8
2006 Mason GF, Krystal JH. MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseases. Nmr in Biomedicine. 19: 690-701. PMID 16986118 DOI: 10.1002/nbm.1080  0.8
2006 D'Souza DC, Gil RB, Madonick S, Perry EB, Forselius-Bielen K, Braley G, Donahue L, Tellioglu T, Zimolo Z, Gueorguieva R, Krystal JH. Enhanced sensitivity to the euphoric effects of alcohol in schizophrenia. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2767-75. PMID 16985503 DOI: 10.1038/sj.npp.1301207  0.8
2006 Krystal JH, Staley J, Mason G, Petrakis IL, Kaufman J, Harris RA, Gelernter J, Lappalainen J. Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Archives of General Psychiatry. 63: 957-68. PMID 16952998 DOI: 10.1001/archpsyc.63.9.957  0.8
2006 Morgan CJ, Perry EB, Cho HS, Krystal JH, D'Souza DC. Greater vulnerability to the amnestic effects of ketamine in males. Psychopharmacology. 187: 405-14. PMID 16896964 DOI: 10.1007/s00213-006-0409-0  0.8
2006 Amin Z, Mason GF, Cavus I, Krystal JH, Rothman DL, Epperson CN. The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in women. Pharmacology, Biochemistry, and Behavior. 84: 635-43. PMID 16860856 DOI: 10.1016/j.pbb.2006.06.007  0.8
2006 Epperson CN, Gueorguieva R, Czarkowski KA, Stiklus S, Sellers E, Krystal JH, Rothman DL, Mason GF. Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study. Psychopharmacology. 186: 425-33. PMID 16724188 DOI: 10.1007/s00213-006-0313-7  0.8
2006 Pittenger C, Naungayan C, Kendell SF, Coric V, Malison R, Krystal JH, Sanacora GS. Visual hallucinations from the addition of riluzole to memantine and bupropion. Journal of Clinical Psychopharmacology. 26: 218-20. PMID 16633160 DOI: 10.1097/01.jcp.0000203228.64117.9f  0.8
2006 Epperson CN, deWit H, Krystal JH. Advances in the translational neuroscience of neurosteroids. Psychopharmacology. 186: 265-6. PMID 16555064 DOI: 10.1007/s00213-006-0310-x  0.8
2006 Pittenger C, Krystal JH, Coric V. Glutamate-modulating drugs as novel pharmacotherapeutic agents in the treatment of obsessive-compulsive disorder. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 69-81. PMID 16490414 DOI: 10.1016/j.nurx.2005.12.006  0.8
2006 Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, Krystal JH, Gelernter J. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biological Psychiatry. 59: 673-80. PMID 16458264 DOI: 10.1016/j.biopsych.2005.10.026  0.8
2006 Blumberg HP, Krystal JH, Bansal R, Martin A, Dziura J, Durkin K, Martin L, Gerard E, Charney DS, Peterson BS. Age, rapid-cycling, and pharmacotherapy effects on ventral prefrontal cortex in bipolar disorder: a cross-sectional study. Biological Psychiatry. 59: 611-8. PMID 16414030 DOI: 10.1016/j.biopsych.2005.08.031  0.8
2006 Krystal JH, Madonick S, Perry E, Gueorguieva R, Brush L, Wray Y, Belger A, D'Souza DC. Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1793-800. PMID 16395307 DOI: 10.1038/sj.npp.1300994  0.8
2006 Lafleur DL, Pittenger C, Kelmendi B, Gardner T, Wasylink S, Malison RT, Sanacora G, Krystal JH, Coric V. N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder. Psychopharmacology. 184: 254-6. PMID 16374600 DOI: 10.1007/s00213-005-0246-6  0.8
2006 Mason GF, Petrakis IL, de Graaf RA, Gueorguieva R, Guidone E, Coric V, Epperson CN, Rothman DL, Krystal JH. Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking. Biological Psychiatry. 59: 85-93. PMID 16289397 DOI: 10.1016/j.biopsych.2005.06.009  0.8
2006 Pilowsky LS, Bressan RA, Stone JM, Erlandsson K, Mulligan RS, Krystal JH, Ell PJ. First in vivo evidence of an NMDA receptor deficit in medication-free schizophrenic patients. Molecular Psychiatry. 11: 118-9. PMID 16189506 DOI: 10.1038/sj.mp.4001751  0.8
2006 D'Souza DC, Gil RB, Zuzarte E, MacDougall LM, Donahue L, Ebersole JS, Boutros NN, Cooper T, Seibyl J, Krystal JH. gamma-Aminobutyric acid-serotonin interactions in healthy men: implications for network models of psychosis and dissociation. Biological Psychiatry. 59: 128-37. PMID 16140281 DOI: 10.1016/j.biopsych.2005.06.020  0.8
2006 Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF. Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biological Psychiatry. 59: 284-6. PMID 16139814 DOI: 10.1016/j.biopsych.2005.07.015  0.8
2006 D'Souza DC, Krystal JH. Glutamatergic function in the pathophysiology and treatment of psychiatric disorders Primary Psychiatry. 13: 36-37.  0.8
2006 Pittenger C, Bloch M, Wegner R, Teitelbaum C, Krystal JH, Coric V. Glutamatergic dysfunction in obsessive-compulsive disorder and the potential clinical utility of glutamate-modulating agents Primary Psychiatry. 13: 65-77.  0.8
2005 Pittenger C, Kelmendi B, Bloch M, Krystal JH, Coric V. Clinical treatment of obsessive compulsive disorder. Psychiatry (Edgmont (Pa. : Township)). 2: 34-43. PMID 21120095  0.44
2005 Pittenger C, Krystal JH, Coric V. Initial evidence of the beneficial effects of glutamate-modulating agents in the treatment of self-injurious behavior associated with borderline personality disorder. The Journal of Clinical Psychiatry. 66: 1492-3. PMID 16420092  0.44
2005 Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders. 7: 570-6. PMID 16403182 DOI: 10.1111/j.1399-5618.2005.00264.x  0.8
2005 Blumberg HP, Donegan NH, Sanislow CA, Collins S, Lacadie C, Skudlarski P, Gueorguieva R, Fulbright RK, McGlashan TH, Gore JC, Krystal JH. Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder. Psychopharmacology. 183: 308-13. PMID 16249909 DOI: 10.1007/s00213-005-0156-7  0.8
2005 Cho RY, Ford JM, Krystal JH, Laruelle M, Cuthbert B, Carter CS. Functional neuroimaging and electrophysiology biomarkers for clinical trials for cognition in schizophrenia. Schizophrenia Bulletin. 31: 865-9. PMID 16166611 DOI: 10.1093/schbul/sbi050  0.8
2005 Krystal JH, Perry EB, Gueorguieva R, Belger A, Madonick SH, Abi-Dargham A, Cooper TB, Macdougall L, Abi-Saab W, D'Souza DC. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Archives of General Psychiatry. 62: 985-94. PMID 16143730 DOI: 10.1001/archpsyc.62.9.985  0.8
2005 Staley JK, Gottschalk C, Petrakis IL, Gueorguieva R, O'Malley S, Baldwin R, Jatlow P, Verhoeff NP, Perry E, Weinzimmer D, Frohlich E, Ruff E, van Dyck CH, Seibyl JP, Innis RB, ... Krystal JH, et al. Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking. Archives of General Psychiatry. 62: 877-88. PMID 16061765 DOI: 10.1001/archpsyc.62.8.877  0.48
2005 Coric V, Taskiran S, Pittenger C, Wasylink S, Mathalon DH, Valentine G, Saksa J, Wu YT, Gueorguieva R, Sanacora G, Malison RT, Krystal JH. Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial. Biological Psychiatry. 58: 424-8. PMID 15993857 DOI: 10.1016/j.biopsych.2005.04.043  0.8
2005 Hoffman RE, Gueorguieva R, Hawkins KA, Varanko M, Boutros NN, Wu YT, Carroll K, Krystal JH. Temporoparietal transcranial magnetic stimulation for auditory hallucinations: safety, efficacy and moderators in a fifty patient sample. Biological Psychiatry. 58: 97-104. PMID 15936729 DOI: 10.1016/j.biopsych.2005.03.041  0.8
2005 Kiehl KA, Stevens MC, Celone K, Kurtz M, Krystal JH. Abnormal hemodynamics in schizophrenia during an auditory oddball task. Biological Psychiatry. 57: 1029-40. PMID 15860344 DOI: 10.1016/j.biopsych.2005.01.035  0.8
2005 Lappalainen J, Krupitsky E, Remizov M, Pchelina S, Taraskina A, Zvartau E, Somberg LK, Covault J, Kranzler HR, Krystal JH, Gelernter J. Association between alcoholism and gamma-amino butyric acid alpha2 receptor subtype in a Russian population. Alcoholism, Clinical and Experimental Research. 29: 493-8. PMID 15834213 DOI: 10.1097/01.ALC.0000158938.97464.90  0.8
2005 D'Souza DC, Abi-Saab WM, Madonick S, Forselius-Bielen K, Doersch A, Braley G, Gueorguieva R, Cooper TB, Krystal JH. Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction. Biological Psychiatry. 57: 594-608. PMID 15780846 DOI: 10.1016/j.biopsych.2004.12.006  0.8
2005 Kendell SF, Krystal JH, Sanacora G. GABA and glutamate systems as therapeutic targets in depression and mood disorders. Expert Opinion On Therapeutic Targets. 9: 153-68. PMID 15757488 DOI: 10.1517/14728222.9.1.153  0.8
2005 Cho HS, D'Souza DC, Gueorguieva R, Perry EB, Madonick S, Karper LP, Abi-Dargham A, Belger A, Abi-Saab W, Lipschitz D, Bennet A, Seibyl JP, Krystal JH. Absence of behavioral sensitization in healthy human subjects following repeated exposure to ketamine. Psychopharmacology. 179: 136-43. PMID 15682309 DOI: 10.1007/s00213-004-2066-5  0.8
2005 Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi-Saab WM. Extracellular metabolites in the cortex and hippocampus of epileptic patients. Annals of Neurology. 57: 226-35. PMID 15668975 DOI: 10.1002/ana.20380  0.8
2005 Jacobsen LK, Krystal JH, Mencl WE, Westerveld M, Frost SJ, Pugh KR. Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokers. Biological Psychiatry. 57: 56-66. PMID 15607301 DOI: 10.1016/j.biopsych.2004.10.022  0.8
2005 Epperson CN, O'Malley S, Czarkowski KA, Gueorguieva R, Jatlow P, Sanacora G, Rothman DL, Krystal JH, Mason GF. Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy. Biological Psychiatry. 57: 44-8. PMID 15607299 DOI: 10.1016/j.biopsych.2004.09.021  0.8
2005 Krystal JH, Abi-Saab W, Perry E, D'Souza DC, Liu N, Gueorguieva R, McDougall L, Hunsberger T, Belger A, Levine L, Breier A. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology. 179: 303-9. PMID 15309376 DOI: 10.1007/s00213-004-1982-8  0.8
2004 Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH. Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. The American Journal of Psychiatry. 161: 2186-93. PMID 15569888 DOI: 10.1176/appi.ajp.161.12.2186  0.8
2004 Kaufman J, Yang BZ, Douglas-Palumberi H, Houshyar S, Lipschitz D, Krystal JH, Gelernter J. Social supports and serotonin transporter gene moderate depression in maltreated children. Proceedings of the National Academy of Sciences of the United States of America. 101: 17316-21. PMID 15563601 DOI: 10.1073/pnas.0404376101  0.8
2004 Sanacora G, Kendell SF, Fenton L, Coric V, Krystal JH. Riluzole augmentation for treatment-resistant depression. The American Journal of Psychiatry. 161: 2132. PMID 15514421 DOI: 10.1176/appi.ajp.161.11.2132  0.8
2004 Petrakis IL, Limoncelli D, Gueorguieva R, Jatlow P, Boutros NN, Trevisan L, Gelernter J, Krystal JH. Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism. The American Journal of Psychiatry. 161: 1776-82. PMID 15465973 DOI: 10.1176/appi.ajp.161.10.1776  0.8
2004 Blumberg HP, Kaufman J, Martin A, Charney DS, Krystal JH, Peterson BS. Significance of adolescent neurodevelopment for the neural circuitry of bipolar disorder. Annals of the New York Academy of Sciences. 1021: 376-83. PMID 15251913 DOI: 10.1196/annals.1308.048  0.8
2004 Sanacora G, Gueorguieva R, Epperson CN, Wu YT, Appel M, Rothman DL, Krystal JH, Mason GF. Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression. Archives of General Psychiatry. 61: 705-13. PMID 15237082 DOI: 10.1001/archpsyc.61.7.705  0.8
2004 D'Souza DC, Perry E, MacDougall L, Ammerman Y, Cooper T, Wu YT, Braley G, Gueorguieva R, Krystal JH. The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1558-72. PMID 15173844 DOI: 10.1038/sj.npp.1300496  0.8
2004 Jacobsen LK, D'Souza DC, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Nicotine effects on brain function and functional connectivity in schizophrenia. Biological Psychiatry. 55: 850-8. PMID 15050867 DOI: 10.1016/j.biopsych.2003.12.023  0.8
2004 Gueorguieva R, Krystal JH. Move over ANOVA: progress in analyzing repeated-measures data and its reflection in papers published in the Archives of General Psychiatry. Archives of General Psychiatry. 61: 310-7. PMID 14993119 DOI: 10.1001/archpsyc.61.3.310  0.48
2004 Goddard AW, Mason GF, Rothman DL, Behar KL, Petroff OA, Krystal JH. Family psychopathology and magnitude of reductions in occipital cortex GABA levels in panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 639-40. PMID 14973435 DOI: 10.1038/sj.npp.1300374  0.8
2004 Jacobsen LK, Mencl WE, Pugh KR, Skudlarski P, Krystal JH. Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effects. Psychopharmacology. 173: 383-90. PMID 14647960 DOI: 10.1007/s00213-003-1679-4  0.8
2004 Petrakis IL, O'Malley S, Rounsaville B, Poling J, McHugh-Strong C, Krystal JH. Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia. Psychopharmacology. 172: 291-7. PMID 14634716 DOI: 10.1007/s00213-003-1658-9  0.8
2003 Sanacora G, Rothman DL, Mason G, Krystal JH. Clinical studies implementing glutamate neurotransmission in mood disorders. Annals of the New York Academy of Sciences. 1003: 292-308. PMID 14684453 DOI: 10.1196/annals.1300.018  0.8
2003 Krystal JH, Petrakis IL, Krupitsky E, Schutz C, Trevisan L, D'Souza DC. NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. Annals of the New York Academy of Sciences. 1003: 176-84. PMID 14684445 DOI: 10.1196/annals.1300.010  0.8
2003 Blumberg HP, Kaufman J, Martin A, Whiteman R, Zhang JH, Gore JC, Charney DS, Krystal JH, Peterson BS. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry. 60: 1201-8. PMID 14662552 DOI: 10.1001/archpsyc.60.12.1201  0.8
2003 Krystal JH, D'Souza DC, Mathalon D, Perry E, Belger A, Hoffman R. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Psychopharmacology. 169: 215-33. PMID 12955285 DOI: 10.1007/s00213-003-1582-z  0.8
2003 Krystal JH, Petrakis IL, Limoncelli D, Webb E, Gueorgueva R, D'Souza DC, Boutros NN, Trevisan L, Charney DS. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2020-8. PMID 12888778 DOI: 10.1038/sj.npp.1300252  0.8
2003 Blumberg HP, Martin A, Kaufman J, Leung HC, Skudlarski P, Lacadie C, Fulbright RK, Gore JC, Charney DS, Krystal JH, Peterson BS. Frontostriatal abnormalities in adolescents with bipolar disorder: preliminary observations from functional MRI. The American Journal of Psychiatry. 160: 1345-7. PMID 12832254 DOI: 10.1176/appi.ajp.160.7.1345  0.8
2003 Krystal JH, Petrakis IL, Mason G, Trevisan L, D'Souza DC. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Pharmacology & Therapeutics. 99: 79-94. PMID 12804700 DOI: 10.1016/S0163-7258(03)00054-8  0.8
2003 Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A functional magnetic resonance imaging study of bipolar disorder: state- and trait-related dysfunction in ventral prefrontal cortices. Archives of General Psychiatry. 60: 601-9. PMID 12796223 DOI: 10.1001/archpsyc.60.6.601  0.8
2003 Morgan CA, Krystal JH, Southwick SM. Toward early pharmacological posttraumatic stress intervention. Biological Psychiatry. 53: 834-43. PMID 12725976 DOI: 10.1016/S0006-3223(03)00116-1  0.8
2003 Coric V, Milanovic S, Wasylink S, Patel P, Malison R, Krystal JH. Beneficial effects of the antiglutamatergic agent riluzole in a patient diagnosed with obsessive-compulsive disorder and major depressive disorder. Psychopharmacology. 167: 219-20. PMID 12658528 DOI: 10.1007/s00213-003-1396-z  0.44
2003 Sanacora G, Mason GF, Rothman DL, Hyder F, Ciarcia JJ, Ostroff RB, Berman RM, Krystal JH. Increased cortical GABA concentrations in depressed patients receiving ECT. The American Journal of Psychiatry. 160: 577-9. PMID 12611844 DOI: 10.1176/appi.ajp.160.3.577  0.8
2003 Hoffman RE, Hawkins KA, Gueorguieva R, Boutros NN, Rachid F, Carroll K, Krystal JH. Transcranial magnetic stimulation of left temporoparietal cortex and medication-resistant auditory hallucinations. Archives of General Psychiatry. 60: 49-56. PMID 12511172  0.8
2002 Blumberg HP, Charney DS, Krystal JH. Frontotemporal neural systems in bipolar disorder. Seminars in Clinical Neuropsychiatry. 7: 243-54. PMID 12382207  0.8
2002 Epperson CN, Haga K, Mason GF, Sellers E, Gueorguieva R, Zhang W, Weiss E, Rothman DL, Krystal JH. Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Archives of General Psychiatry. 59: 851-8. PMID 12215085  0.8
2002 Petrakis IL, Buonopane A, O'Malley S, Cermik O, Trevisan L, Boutros NN, Limoncelli D, Krystal JH. The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals. Alcoholism, Clinical and Experimental Research. 26: 969-75. PMID 12170105 DOI: 10.1097/01.ALC.0000021338.38350.95  0.8
2002 Abi-Saab W, Seibyl JP, D'Souza DC, Karper LP, Gueorgueva R, Abi-Dargham A, Wong ML, Rajhans S, Erdos JP, Heninger GR, Charney DS, Krystal JH. Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology. 162: 55-62. PMID 12107618 DOI: 10.1007/s00213-002-1057-7  0.8
2002 Krystal JH, Anand A, Moghaddam B. Effects of NMDA receptor antagonists: implications for the pathophysiology of schizophrenia. Archives of General Psychiatry. 59: 663-4. PMID 12090822  0.8
2002 Jacobsen LK, Gore JC, Skudlarski P, Lacadie CM, Jatlow P, Krystal JH. Impact of intravenous nicotine on BOLD signal response to photic stimulation. Magnetic Resonance Imaging. 20: 141-5. PMID 12034334  0.44
2002 Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry. 7: S71-80. PMID 11986998 DOI: 10.1038/sj.mp.4001021  0.8
2002 Boutros NN, Gelernter J, Gooding DC, Cubells J, Young A, Krystal JH, Kosten T. Sensory gating and psychosis vulnerability in cocaine-dependent individuals: preliminary data. Biological Psychiatry. 51: 683-6. PMID 11955469 DOI: 10.1016/S0006-3223(01)01237-9  0.8
2002 Stine SM, Southwick SM, Petrakis IL, Kosten TR, Charney DS, Krystal JH. Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients. Biological Psychiatry. 51: 642-51. PMID 11955464  0.8
2002 Sanacora G, Mason GF, Rothman DL, Krystal JH. Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. The American Journal of Psychiatry. 159: 663-5. PMID 11925309 DOI: 10.1176/appi.ajp.159.4.663  0.8
2002 Abi-Saab WM, Maggs DG, Jones T, Jacob R, Srihari V, Thompson J, Kerr D, Leone P, Krystal JH, Spencer DD, During MJ, Sherwin RS. Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 271-9. PMID 11891432 DOI: 10.1097/00004647-200203000-00004  0.8
2001 Krupitsky EM, Burakov AM, Romanova TN, Grinenko NI, Grinenko AY, Fletcher J, Petrakis IL, Krystal JH. Attenuation of ketamine effects by nimodipine pretreatment in recovering ethanol dependent men: psychopharmacologic implications of the interaction of NMDA and L-type calcium channel antagonists. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 936-47. PMID 11750186 DOI: 10.1016/S0893-133X(01)00346-3  0.4
2001 Krystal JH, Cramer JA, Krol WF, Kirk GF, Rosenheck RA. Naltrexone in the treatment of alcohol dependence. The New England Journal of Medicine. 345: 1734-9. PMID 11742047 DOI: 10.1056/NEJMoa011127  0.8
2001 Krystal JH, D'Souza DC. Comment on "Ketamine has equal affinity for NMDA receptors and the high-affinity state of the dopamine D(2) receptor". Biological Psychiatry. 50: 555-6. PMID 11600110  0.4
2001 Chambers RA, Krystal JH, Self DW. A neurobiological basis for substance abuse comorbidity in schizophrenia. Biological Psychiatry. 50: 71-83. PMID 11526998 DOI: 10.1016/S0006-3223(01)01134-9  0.8
2001 Petrakis IL, Trevisan L, Boutros NN, Limoncelli D, Cooney NL, Krystal JH. Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients. Alcoholism, Clinical and Experimental Research. 25: 1151-5. PMID 11505046  0.8
2001 Goddard AW, Mason GF, Almai A, Rothman DL, Behar KL, Petroff OA, Charney DS, Krystal JH. Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy. Archives of General Psychiatry. 58: 556-61. PMID 11386984  0.8
2001 Stine SM, Grillon CG, Morgan CA, Kosten TR, Charney DS, Krystal JH. Methadone patients exhibit increased startle and cortisol response after intravenous yohimbine. Psychopharmacology. 154: 274-81. PMID 11351934 DOI: 10.1007/s002130000644  0.8
2001 Krystal JH, D'Souza DC, Sanacora G, Goddard AW, Charney DS. Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders. The Medical Clinics of North America. 85: 559-77. PMID 11349473 DOI: 10.1016/S0025-7125(05)70329-1  0.8
2001 Boutros NN, Lisanby SH, Tokuno H, Torello MW, Campbell D, Berman R, Malison R, Krystal JH, Kosten T. Elevated motor threshold in drug-free, cocaine-dependent patients assessed with transcranial magnetic stimulation. Biological Psychiatry. 49: 369-73. PMID 11239908 DOI: 10.1016/S0006-3223(00)00948-3  0.8
2001 Jacobsen LK, Giedd JN, Gottschalk C, Kosten TR, Krystal JH. Quantitative morphology of the caudate and putamen in patients with cocaine dependence. The American Journal of Psychiatry. 158: 486-9. PMID 11229995 DOI: 10.1176/appi.ajp.158.3.486  0.8
2000 Sanacora G, Mason GF, Krystal JH. Impairment of GABAergic transmission in depression: new insights from neuroimaging studies. Critical Reviews in Neurobiology. 14: 23-45. PMID 11253954  0.8
2000 Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH, Charney DS. Transcranial magnetic stimulation and auditory hallucinations in schizophrenia. Lancet. 355: 1073-5. PMID 10744097 DOI: 10.1016/S0140-6736(00)02043-2  0.8
2000 Anand A, Charney DS, Oren DA, Berman RM, Hu XS, Cappiello A, Krystal JH. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine: support for hyperglutamatergic effects of N-methyl-D-aspartate receptor antagonists. Archives of General Psychiatry. 57: 270-6. PMID 10711913  0.8
2000 D'Souza DC, Gil R, Cassello K, Morrissey K, Abi-Saab D, White J, Sturwold R, Bennett A, Karper LP, Zuzarte E, Charney DS, Krystal JH. IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans. Biological Psychiatry. 47: 450-62. PMID 10704956 DOI: 10.1016/S0006-3223(99)00133-X  0.8
2000 Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS, Krystal JH. Antidepressant effects of ketamine in depressed patients. Biological Psychiatry. 47: 351-4. PMID 10686270 DOI: 10.1016/S0006-3223(99)00230-9  0.8
2000 Krystal JH, Bennett A, Abi-Saab D, Belger A, Karper LP, D'Souza DC, Lipschitz D, Abi-Dargham A, Charney DS. Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biological Psychiatry. 47: 137-43. PMID 10664830 DOI: 10.1016/S0006-3223(99)00097-9  0.8
1999 Verhoeff NP, Soares JC, D'Souza CD, Gil R, Degen K, Abi-Dargham A, Zoghbi SS, Fujita M, Rajeevan N, Seibyl JP, Krystal JH, van Dyck CH, Charney DS, Innis RB. [123I]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia. Psychiatry Research. 91: 163-73. PMID 10641580  0.8
1999 Sanacora G, Mason GF, Rothman DL, Behar KL, Hyder F, Petroff OA, Berman RM, Charney DS, Krystal JH. Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Archives of General Psychiatry. 56: 1043-7. PMID 10565505 DOI: 10.1001/archpsyc.56.11.1043  0.8
1999 Chambers RA, Bremner JD, Moghaddam B, Southwick SM, Charney DS, Krystal JH. Glutamate and post-traumatic stress disorder: toward a psychobiology of dissociation. Seminars in Clinical Neuropsychiatry. 4: 274-81. PMID 10553033 DOI: 10.153/SCNP00400274  0.8
1999 Southwick SM, Paige S, Morgan CA, Bremner JD, Krystal JH, Charney DS. Neurotransmitter alterations in PTSD: catecholamines and serotonin. Seminars in Clinical Neuropsychiatry. 4: 242-8. PMID 10553029 DOI: 10.153/SCNP00400242  0.8
1999 D'Souza DC, Berman RM, Krystal JH, Charney DS. Symptom provocation studies in psychiatric disorders: scientific value, risks, and future. Biological Psychiatry. 46: 1060-80. PMID 10536743 DOI: 10.1016/S0006-3223(99)00209-7  0.8
1999 Krystal JH, D'Souza DC, Petrakis IL, Belger A, Berman RM, Charney DS, Abi-Saab W, Madonick S. NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders. Harvard Review of Psychiatry. 7: 125-43. PMID 10483932  0.8
1999 Petrakis IL, Trevisan L, D'Souza C, Gil R, Krasnicki S, Webb E, Heninger G, Cooney N, Krystal JH. CSF monoamine metabolite and beta endorphin levels in recently detoxified alcoholics and healthy controls: prediction of alcohol cue-induced craving? Alcoholism, Clinical and Experimental Research. 23: 1336-41. PMID 10470976  0.4
1999 Krystal JH, D'Souza DC, Karper LP, Bennett A, Abi-Dargham A, Abi-Saab D, Cassello K, Bowers MB, Vegso S, Heninger GR, Charney DS. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Psychopharmacology. 145: 193-204. PMID 10463321 DOI: 10.1007/s002130051049  0.8
1999 Delgado PL, Miller HL, Salomon RM, Licinio J, Krystal JH, Moreno FA, Heninger GR, Charney DS. Tryptophan-depletion challenge in depressed patients treated with desipramine or fluoxetine: implications for the role of serotonin in the mechanism of antidepressant action. Biological Psychiatry. 46: 212-20. PMID 10418696 DOI: 10.1016/S0006-3223(99)00014-1  0.8
1999 Hoffman RE, Boutros NN, Berman RM, Roessler E, Belger A, Krystal JH, Charney DS. Transcranial magnetic stimulation of left temporoparietal cortex in three patients reporting hallucinated "voices". Biological Psychiatry. 46: 130-2. PMID 10394483 DOI: 10.1016/S0006-3223(98)00358-8  0.8
1999 Behar KL, Rothman DL, Petersen KF, Hooten M, Delaney R, Petroff OA, Shulman GI, Navarro V, Petrakis IL, Charney DS, Krystal JH. Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients. The American Journal of Psychiatry. 156: 952-4. PMID 10360140  0.8
1999 Bunney WE, Azarnoff DL, Brown BW, Cancro R, Gibbons RD, Gillin JC, Hullett S, Killam KF, Kupfer DJ, Krystal JH, Stolley PD, French GS, Pope AM. Report of the Institute of Medicine Committee on the Efficacy and Safety of Halcion. Archives of General Psychiatry. 56: 349-52. PMID 10197830  0.8
1999 Fujita M, Woods SW, Verhoeff NP, Abi-Dargham A, Baldwin RM, Zoghbi SS, Soares JC, Jatlow PA, Krystal JH, Rajeevan N, Charney DS, Seibyl JP, Innis RB. Changes of benzodiazepine receptors during chronic benzodiazepine administration in humans. European Journal of Pharmacology. 368: 161-72. PMID 10193652  0.8
1999 Krystal JH, D'Souza DC, Madonick S, Petrakis IL. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Schizophrenia Research. 35: S35-49. PMID 10190224 DOI: 10.1016/S0920-9964(98)00162-5  0.8
1998 Trevisan LA, Boutros N, Petrakis IL, Krystal JH. Complications of alcohol withdrawal: pathophysiological insights. Alcohol Health and Research World. 22: 61-6. PMID 15706735  0.4
1998 Krystal JH, D'Souza DC. D-serine and the therapeutic challenge posed by the N-methyl-D-aspartate antagonist model of schizophrenia. Biological Psychiatry. 44: 1075-6. PMID 9836009 DOI: 10.1016/S0006-3223(98)00284-4  0.8
1998 Abi-Dargham A, Krystal JH, Anjilvel S, Scanley BE, Zoghbi S, Baldwin RM, Rajeevan N, Ellis S, Petrakis IL, Seibyl JP, Charney DS, Laruelle M, Innis RB. Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. The American Journal of Psychiatry. 155: 1550-5. PMID 9812116  0.8
1998 Abi-Saab WM, D'Souza DC, Moghaddam B, Krystal JH. The NMDA antagonist model for schizophrenia: promise and pitfalls. Pharmacopsychiatry. 31: 104-9. PMID 9754841 DOI: 10.1055/s-2007-979354  0.4
1998 Belger A, Puce A, Krystal JH, Gore JC, Goldman-Rakic P, McCarthy G. Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Human Brain Mapping. 6: 14-32. PMID 9673660 DOI: 10.1002/(SICI)1097-0193(1998)6:1<14::AID-HBM2>3.0.CO;2-O  0.8
1998 Sernyak MJ, Glazer WM, Heninger GR, Charney DS, Woods SW, Petrakis IL, Krystal JH, Price LH. Naltrexone augmentation of neuroleptics in schizophrenia. Journal of Clinical Psychopharmacology. 18: 248-51. PMID 9617985 DOI: 10.1097/00004714-199806000-00011  0.8
1998 Krystal JH, Petrakis IL, Webb E, Cooney NL, Karper LP, Namanworth S, Stetson P, Trevisan LA, Charney DS. Dose-related ethanol-like effects of the NMDA antagonist, ketamine, in recently detoxified alcoholics. Archives of General Psychiatry. 55: 354-60. PMID 9554431 DOI: 10.1001/archpsyc.55.4.354  0.8
1998 Krystal JH, Karper LP, Bennett A, D'Souza DC, Abi-Dargham A, Morrissey K, Abi-Saab D, Bremner JD, Bowers MB, Suckow RF, Stetson P, Heninger GR, Charney DS. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans. Psychopharmacology. 135: 213-29. PMID 9498724 DOI: 10.1007/s002130050503  0.8
1998 Bremner JD, Krystal JH, Putnam FW, Southwick SM, Marmar C, Charney DS, Mazure CM. Measurement of dissociative states with the Clinician-Administered Dissociative States Scale (CADSS). Journal of Traumatic Stress. 11: 125-36. PMID 9479681 DOI: 10.1023/A:1024465317902  0.8
1997 Southwick SM, Krystal JH, Bremner JD, Morgan CA, Nicolaou AL, Nagy LM, Johnson DR, Heninger GR, Charney DS. Noradrenergic and serotonergic function in posttraumatic stress disorder. Archives of General Psychiatry. 54: 749-58. PMID 9283511  0.8
1997 Southwick SM, Morgan CA, Bremner AD, Grillon CG, Krystal JH, Nagy LM, Charney DS. Noradrenergic alterations in posttraumatic stress disorder. Annals of the New York Academy of Sciences. 821: 125-41. PMID 9238199 DOI: 10.1111/j.1749-6632.1997.tb48274.x  0.8
1997 Stine SM, Krystal JH, Petrakis IL, Jatlow PI, Heninger GR, Kosten TR, Charney DS. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry. 42: 181-90. PMID 9232210  0.8
1997 Krystal JH, Webb E, Grillon C, Cooney N, Casal L, Morgan CA, Southwick SM, Davis M, Charney DS. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-chlorophenylpiperazine (mCPP). Psychopharmacology. 131: 207-15. PMID 9203230 DOI: 10.1007/s002130050285  0.8
1997 Bremner JD, Licinio J, Darnell A, Krystal JH, Owens MJ, Southwick SM, Nemeroff CB, Charney DS. Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder. The American Journal of Psychiatry. 154: 624-9. PMID 9137116  0.8
1997 Bremner JD, Innis RB, Salomon RM, Staib LH, Ng CK, Miller HL, Bronen RA, Krystal JH, Duncan J, Rich D, Price LH, Malison R, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of tryptophan depletion-induced depressive relapse. Archives of General Psychiatry. 54: 364-74. PMID 9107153  0.8
1997 Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Archives of General Psychiatry. 54: 246-54. PMID 9075465  0.8
1997 Salomon RM, Miller HL, Krystal JH, Heninger GR, Charney DS. Lack of behavioral effects of monoamine depletion in healthy subjects. Biological Psychiatry. 41: 58-64. PMID 8988796 DOI: 10.1016/0006-3223(95)00670-2  0.8
1996 Krystal JH, Deutsch DN, Charney DS. The biological basis of panic disorder. The Journal of Clinical Psychiatry. 57: 23-31; discussion 32. PMID 8917129  0.8
1996 Karper LP, Freeman GK, Grillon C, Morgan CA, Charney DS, Krystal JH. Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis. The Journal of Neuropsychiatry and Clinical Neurosciences. 8: 60-6. PMID 8845703  0.8
1996 Laruelle M, Abi-Dargham A, van Dyck CH, Gil R, D'Souza CD, Erdos J, McCance E, Rosenblatt W, Fingado C, Zoghbi SS, Baldwin RM, Seibyl JP, Krystal JH, Charney DS, Innis RB. Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects. Proceedings of the National Academy of Sciences of the United States of America. 93: 9235-40. PMID 8799184  0.8
1996 Krystal JH, Compere S, Nestler EJ, Rasmussen K. Nimodipine reduction of naltrexone-precipitated locus coeruleus activation and abstinence behavior in morphine-dependent rats. Physiology & Behavior. 59: 863-6. PMID 8778878 DOI: 10.1016/0031-9384(95)02206-6  0.8
1996 Bremner JD, Krystal JH, Southwick SM, Charney DS. Noradrenergic mechanisms in stress and anxiety: II. Clinical studies. Synapse (New York, N.Y.). 23: 39-51. PMID 8723134 DOI: 10.1002/(SICI)1098-2396(199605)23:1<39::AID-SYN5>3.0.CO;2-I  0.8
1996 Bremner JD, Krystal JH, Southwick SM, Charney DS. Noradrenergic mechanisms in stress and anxiety: I. Preclinical studies. Synapse (New York, N.Y.). 23: 28-38. PMID 8723133 DOI: 10.1002/(SICI)1098-2396(199605)23:1<28::AID-SYN4>3.0.CO;2-J  0.8
1996 McCarthy G, Puce A, Constable RT, Krystal JH, Gore JC, Goldman-Rakic P. Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. Cerebral Cortex (New York, N.Y. : 1991). 6: 600-11. PMID 8670685  0.8
1996 Bremner JD, Krystal JH, Charney DS, Southwick SM. Neural mechanisms in dissociative amnesia for childhood abuse: relevance to the current controversy surrounding the "false memory syndrome". The American Journal of Psychiatry. 153: 71-82. PMID 8659644  0.8
1996 Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and biochemical effects of catecholamine depletion on antidepressant-induced remission of depression. Archives of General Psychiatry. 53: 117-28. PMID 8629887  0.8
1996 Hillbrand M, Young JL, Krystal JH. Recurrent self-injurious behavior in forensic patients. The Psychiatric Quarterly. 67: 33-45. PMID 8623037  0.8
1996 Seibyl JP, Zea-Ponce Y, Brenner L, Baldwin RM, Krystal JH, Offord SJ, Mochoviak S, Charney DS, Hoffer PB, Innis RB. Continuous intravenous infusion of iodine-123-IBZM for SPECT determination of human brain dopamine receptor occupancy by antipsychotic agent RWJ-37796. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 37: 11-5. PMID 8543979  0.8
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