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Juan A. Faraldos, Ph.D. - Publications

Affiliations: 
2003 SUNY College of Environmental Science and Forestry, Syracuse, NY, United States 
Area:
Organic Chemistry, Biochemistry
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Demiray M, Tang X, Wirth T, Faraldos JA, Allemann RK. An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde. Angewandte Chemie (International Ed. in English). PMID 28294491 DOI: 10.1002/Anie.201609557  0.386
2016 Faraldos JA, Grundy DJ, Cascon O, Leoni S, van der Kamp MW, Allemann RK. Enzymatic synthesis of natural (+)-aristolochene from a non-natural substrate. Chemical Communications (Cambridge, England). PMID 27853760 DOI: 10.1039/C6Cc08164A  0.419
2016 Chen M, Chou WK, Al-Lami N, Faraldos JA, Allemann RK, Cane DE, Christianson DW. Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase. Biochemistry. PMID 27172425 DOI: 10.1021/Acs.Biochem.6B00343  0.301
2015 Salmon M, Laurendon C, Vardakou M, Cheema J, Defernez M, Green S, Faraldos JA, O'Maille PE. Emergence of terpene cyclization in Artemisia annua. Nature Communications. 6: 6143. PMID 25644758 DOI: 10.1038/Ncomms7143  0.338
2014 Vardakou M, Salmon M, Faraldos JA, O'Maille PE. Comparative analysis and validation of the malachite green assay for the high throughput biochemical characterization of terpene synthases. Methodsx. 1: 187-96. PMID 26150952 DOI: 10.1016/J.Mex.2014.08.007  0.306
2014 Gonzalez V, Touchet S, Grundy DJ, Faraldos JA, Allemann RK. Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase. Journal of the American Chemical Society. 136: 14505-12. PMID 25230152 DOI: 10.1021/Ja5066366  0.387
2013 Faraldos JA, Coates RM, Giner JL. Alternative synthesis of the Colorado potato beetle pheromone. The Journal of Organic Chemistry. 78: 10548-54. PMID 24047429 DOI: 10.1021/Jo4017056  0.595
2013 Chen M, Al-lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW. Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase. Biochemistry. 52: 5441-53. PMID 23905850 DOI: 10.1021/Bi400691V  0.369
2013 Li JX, Fang X, Zhao Q, Ruan JX, Yang CQ, Wang LJ, Miller DJ, Faraldos JA, Allemann RK, Chen XY, Zhang P. Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency. The Biochemical Journal. 451: 417-26. PMID 23438177 DOI: 10.1042/Bj20130041  0.359
2012 Faraldos JA, Gonzalez V, Li A, Yu F, Köksal M, Christianson DW, Allemann RK. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. Journal of the American Chemical Society. 134: 20844-8. PMID 23214943 DOI: 10.1021/Ja311022S  0.354
2012 Cascón O, Touchet S, Miller DJ, Gonzalez V, Faraldos JA, Allemann RK. Chemoenzymatic preparation of germacrene analogues. Chemical Communications (Cambridge, England). 48: 9702-4. PMID 22914774 DOI: 10.1039/C2Cc35542F  0.34
2012 Yoosuf-Aly Z, Faraldos JA, Miller DJ, Allemann RK. Chemoenzymatic synthesis of the alarm pheromone (+)-verbenone from geranyl diphosphate. Chemical Communications (Cambridge, England). 48: 7040-2. PMID 22684271 DOI: 10.1039/C2Cc32883F  0.344
2012 Faraldos JA, Miller DJ, González V, Yoosuf-Aly Z, Cascón O, Li A, Allemann RK. A 1,6-ring closure mechanism for (+)-δ-cadinene synthase? Journal of the American Chemical Society. 134: 5900-8. PMID 22397618 DOI: 10.1021/Ja211820P  0.408
2012 Faraldos JA, Gonzalez V, Allemann RK. The role of aristolochene synthase in diphosphate activation. Chemical Communications (Cambridge, England). 48: 3230-2. PMID 22349314 DOI: 10.1039/C2Cc17588F  0.319
2011 Faraldos JA, González V, Senske M, Allemann RK. Templating effects in aristolochene synthase catalysis: elimination versus cyclisation. Organic & Biomolecular Chemistry. 9: 6920-3. PMID 21870004 DOI: 10.1039/C1Ob06184D  0.34
2011 Faraldos JA, Antonczak AK, González V, Fullerton R, Tippmann EM, Allemann RK. Probing eudesmane cation-π interactions in catalysis by aristolochene synthase with non-canonical amino acids. Journal of the American Chemical Society. 133: 13906-9. PMID 21815676 DOI: 10.1021/Ja205927U  0.367
2011 Faraldos JA, Kariuki BM, Coates RM. 2-azapinanes: aza analogues of the enantiomeric pinyl carbocation intermediates in pinene biosynthesis. Organic Letters. 13: 836-9. PMID 21261271 DOI: 10.1021/Ol1027893  0.363
2010 Kaspera R, Cape JL, Faraldos JA, Ketchum RE, Croteau RB. Synthesis and In Vitro Evaluation of Taxol oxetane ring D precursors. Tetrahedron Letters. 51: 2017-2019. PMID 20305723 DOI: 10.1016/J.Tetlet.2010.02.033  0.391
2010 Faraldos JA, O'Maille PE, Dellas N, Noel JP, Coates RM. Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. Journal of the American Chemical Society. 132: 4281-9. PMID 20201526 DOI: 10.1021/Ja909886Q  0.364
2010 Noel JP, Dellas N, Faraldos JA, Zhao M, Hess BA, Smentek L, Coates RM, O'Maille PE. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. Acs Chemical Biology. 5: 377-92. PMID 20175559 DOI: 10.1021/Cb900295G  0.386
2010 Faraldos JA, Wu S, Chappell J, Coates RM. Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-(2)H(1)]farnesyl diphosphate catalyzed by recombinant patchoulol synthase. Journal of the American Chemical Society. 132: 2998-3008. PMID 20148554 DOI: 10.1021/Ja909251R  0.308
2010 Faraldos JA, Kariuki B, Allemann RK. Intermediacy of eudesmane cation during catalysis by aristolochene synthase. The Journal of Organic Chemistry. 75: 1119-25. PMID 20095558 DOI: 10.1021/Jo902397V  0.421
2009 Hu H, Faraldos JA, Coates RM. Scope and mechanism of intramolecular aziridination of cyclopent-3-enyl-methylamines to 1-azatricyclo[2.2.1.0(2,6)]heptanes with lead tetraacetate. Journal of the American Chemical Society. 131: 11998-2006. PMID 19653649 DOI: 10.1021/Ja9044136  0.322
2008 Shishova EY, Yu F, Miller DJ, Faraldos JA, Zhao Y, Coates RM, Allemann RK, Cane DE, Christianson DW. X-ray crystallographic studies of substrate binding to aristolochene synthase suggest a metal ion binding sequence for catalysis. The Journal of Biological Chemistry. 283: 15431-9. PMID 18385128 DOI: 10.1074/Jbc.M800659200  0.311
2007 Faraldos JA, Zhao Y, O'Maille PE, Noel JP, Coates RM. Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem : a European Journal of Chemical Biology. 8: 1826-33. PMID 17886322 DOI: 10.1002/Cbic.200700398  0.391
2007 Grace MH, Faraldos JA, Lila MA, Coates RM. ent-Beyerane diterpenoids from the heartwood of Excoecaria parvifolia. Phytochemistry. 68: 546-53. PMID 17196627 DOI: 10.1016/J.Phytochem.2006.11.010  0.336
2003 Giner JL, Faraldos JA, Boyer GL. NOVEL STEROLS OF THE TOXIC DINOFLAGELLATE KARENIA BREVIS (DINOPHYCEAE): A DEFENSIVE FUNCTION FOR UNUSUAL MARINE STEROLS?. Journal of Phycology. 39: 315-319. PMID 33066707 DOI: 10.1046/j.1529-8817.2003.01254.x  0.529
2003 Giner JL, Faraldos JA, Boyer GL. Novel sterols of the toxic dinoflagellate Karenia brevis (Dinophyceae): A defensive function for unusual marine sterols? Journal of Phycology. 39: 315-319. DOI: 10.1046/J.1529-8817.2003.01254.X  0.556
2003 Giner JL, Faraldos JA. Facile Orthoester Formation in a Model Compound of the Taxol Oxetane: Are Biologically Active Epoxy Esters, Orthoesters, and Oxetanyl Esters Latent Electrophiles? Helvetica Chimica Acta. 86: 3613-3622. DOI: 10.1002/Hlca.200390306  0.576
2002 Faraldos JA, Giner JL. Biomimetic synthesis of petuniasterone D via the epoxy ester[bond]ortho ester rearrangement. The Journal of Organic Chemistry. 67: 4659-66. PMID 12098273 DOI: 10.1021/Jo020068S  0.581
2002 Giner JL, Faraldos JA. A biomimetic approach to the synthesis of an antiviral marine steroidal orthoester. The Journal of Organic Chemistry. 67: 2717-20. PMID 11950327 DOI: 10.1021/Jo011111Z  0.593
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