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Byron DeLaBarre, Ph.D. - Publications

Affiliations: 
2000 McMaster University, Hamilton, ON, Canada 
Area:
Biochemistry
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood HJ, DeLaBarre B, Tong L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. PMID 30944472 DOI: 10.1038/S41586-019-1094-6  0.413
2019 Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood Jr HJ, DeLaBarre B, Tong L. Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor Acta Crystallographica Section a Foundations and Advances. 75: a371-a371. DOI: 10.1107/S0108767319096387  0.305
2017 Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. PMID 28760888 DOI: 10.1182/Blood-2016-11-753525  0.304
2017 Yen K, Travins J, Wang F, David MD, Artin E, Straley K, Padyana A, Gross S, DeLaBarre B, Tobin E, Chen Y, Nagaraja R, Choe S, Jin L, Konteatis Z, et al. AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discovery. PMID 28193778 DOI: 10.1158/2159-8290.Cd-16-1034  0.317
2014 Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo HK, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB. Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition. Plos One. 9: e115144. PMID 25502225 DOI: 10.1371/Journal.Pone.0115144  0.316
2014 DeLaBarre B, Hurov J, Cianchetta G, Murray S, Dang L. Action at a distance: allostery and the development of drugs to target cancer cell metabolism. Chemistry & Biology. 21: 1143-61. PMID 25237859 DOI: 10.1016/J.Chembiol.2014.08.007  0.319
2014 Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A. Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. The Journal of Biological Chemistry. 289: 13717-25. PMID 24668804 DOI: 10.1074/Jbc.M113.511030  0.339
2014 DeLaBarre B, Wang F, Travins J, Gross S, Artin E, Dang L, Biller S, Yen K. Structural Biology of Mutant IDH2 Inhibition Acta Crystallographica Section a Foundations and Advances. 70: C799-C799. DOI: 10.1107/S2053273314092006  0.431
2013 Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science (New York, N.Y.). 340: 622-6. PMID 23558173 DOI: 10.1126/Science.1234769  0.426
2013 Kung C, Hixon J, Kosinski P, Histen G, Hill C, Si Y, Kernytsky A, Chen Y, DeLaBarre B, Clasquin M, Ho H, Cossor FI, Neufeld EJ, Salituro F, Popovici-Muller J, et al. Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia Blood. 122: 2180-2180. DOI: 10.1182/Blood.V122.21.2180.2180  0.373
2013 Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, et al. Abstract PL02-04: IDH mutations and tumorigenicity. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl02-04  0.333
2012 Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/J.Chembiol.2012.07.021  0.323
2012 Delabarre B, Hurov J, Gross S. Abstract 3237: XRay structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants Cancer Research. 72: 3237-3237. DOI: 10.1158/1538-7445.Am2012-3237  0.38
2011 DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry. 50: 10764-70. PMID 22049910 DOI: 10.1021/Bi201613D  0.408
2007 Anderson MJ, DeLabarre B, Raghunathan A, Palsson BO, Brunger AT, Quake SR. Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices. Biochemistry. 46: 5722-31. PMID 17441732 DOI: 10.1021/Bi700096P  0.408
2006 DeLaBarre B, Christianson JC, Kopito RR, Brunger AT. Central pore residues mediate the p97/VCP activity required for ERAD. Molecular Cell. 22: 451-62. PMID 16713576 DOI: 10.1016/J.Molcel.2006.03.036  0.34
2005 DeLaBarre B, Brunger AT. Nucleotide dependent motion and mechanism of action of p97/VCP. Journal of Molecular Biology. 347: 437-52. PMID 15740751 DOI: 10.1016/J.Jmb.2005.01.060  0.351
2003 DeLaBarre B, Brunger AT. Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nature Structural Biology. 10: 856-63. PMID 12949490 DOI: 10.1038/Nsb972  0.384
2002 Rouiller I, DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM. Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nature Structural Biology. 9: 950-7. PMID 12434150 DOI: 10.1038/Nsb872  0.304
2000 DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nature Structural Biology. 7: 238-44. PMID 10700284 DOI: 10.1038/73359  0.538
1998 DeLaBarre B, Jacques SL, Pratt CE, Ruth DA, Wright GD, Berghuis AM. Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. Acta Crystallographica. Section D, Biological Crystallography. 54: 413-5. PMID 9761913 DOI: 10.1107/S0907444997011967  0.504
1996 DeLaBarre B, Wright GD, Berghuis AM. Crystallographic studies of homoserine dehydrogenase for the design of novel antifungal agents Acta Crystallographica Section a Foundations of Crystallography. 52: C99-C99. DOI: 10.1107/S0108767396095153  0.469
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