David J. Bzik - Publications

Affiliations: 
Immunology and Microbiology Dartmouth College, Hanover, NH, United States 
Area:
Microbiology Biology, Parasitology Biology

69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Hasan T, Shimoda N, Nakamura S, Fox BA, Bzik DJ, Ushio-Watanabe N, Nishikawa Y. Protective efficacy of recombinant Toxoplasma gondii dense granule protein 15 against toxoplasmosis in C57BL/6 mice. Vaccine. PMID 38429153 DOI: 10.1016/j.vaccine.2024.02.062  0.4
2023 Mani R, Abdelaziz MH, Ochiai E, Sa Q, Fox BA, Bzik DJ, Suzuki Y. Dense granule protein 3 of plays a crucial role in the capability of the tissue cysts of the parasite to persist in the presence of anti-cyst CD8 T cells during the chronic stage of infection. Frontiers in Immunology. 14: 1272221. PMID 37868957 DOI: 10.3389/fimmu.2023.1272221  0.378
2021 Zhao Y, Reyes J, Rovira-Diaz E, Fox BA, Bzik DJ, Yap GS. Cutting Edge: CD36 Mediates Phagocyte Tropism and Avirulence of . Journal of Immunology (Baltimore, Md. : 1950). PMID 34400524 DOI: 10.4049/jimmunol.2100605  0.302
2021 Guevara RB, Fox BA, Bzik DJ. A Family of Toxoplasma gondii Genes Related to GRA12 Regulate Cyst Burdens and Cyst Reactivation. Msphere. 6. PMID 33883265 DOI: 10.1128/mSphere.00182-21  0.306
2020 Mercer HL, Snyder LM, Doherty CM, Fox BA, Bzik DJ, Denkers EY. Toxoplasma gondii dense granule protein GRA24 drives MyD88-independent p38 MAPK activation, IL-12 production and induction of protective immunity. Plos Pathogens. 16: e1008572. PMID 32413093 DOI: 10.1371/journal.ppat.1008572  0.309
2019 Rommereim LM, Fox BA, Butler KL, Cantillana V, Taylor GA, Bzik DJ. Rhoptry and Dense Granule Secreted Effectors Regulate CD8 T Cell Recognition of Infected Host Cells. Frontiers in Immunology. 10: 2104. PMID 31555296 DOI: 10.3389/Fimmu.2019.02104  0.512
2019 Fox BA, Guevara RB, Rommereim LM, Falla A, Bellini V, Pètre G, Rak C, Cantillana V, Dubremetz JF, Cesbron-Delauw MF, Taylor GA, Mercier C, Bzik DJ. Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon. Mbio. 10. PMID 31266861 DOI: 10.1128/mBio.00589-19  0.312
2018 Shukla A, Olszewski KL, Llinás M, Rommereim LM, Fox BA, Bzik DJ, Xia D, Wastling J, Beiting D, Roos DS, Shanmugam D. Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii. International Journal For Parasitology. PMID 30176233 DOI: 10.1016/J.Ijpara.2018.05.013  0.312
2017 Abdelbaset AE, Fox BA, Karram MH, Abd Ellah MR, Bzik DJ, Igarashi M. Lactate dehydrogenase in Toxoplasma gondii controls virulence, bradyzoite differentiation, and chronic infection. Plos One. 12: e0173745. PMID 28323833 DOI: 10.1371/Journal.Pone.0173745  0.403
2016 Konradt C, Ueno N, Christian DA, Delong JH, Pritchard GH, Herz J, Bzik DJ, Koshy AA, McGavern DB, Lodoen MB, Hunter CA. Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system. Nature Microbiology. 1: 16001. PMID 27572166 DOI: 10.1038/Nmicrobiol.2016.1  0.379
2016 Hortua Triana MA, Herrera DC, Zimmermann BH, Fox BA, Bzik DJ. Pyrimidine pathway dependent and independent functions of the Toxoplasma gondii mitochondrial dihydroorotate dehydrogenase. Infection and Immunity. PMID 27481247 DOI: 10.1128/Iai.00187-16  0.351
2016 Rommereim LM, Bellini V, Fox BA, Pètre G, Rak C, Touquet B, Aldebert D, Dubremetz JF, Cesbron-Delauw MF, Mercier C, Bzik DJ. Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii. Plos One. 11: e0159306. PMID 27458822 DOI: 10.1371/Journal.Pone.0159306  0.436
2016 Fox BA, Sanders KL, Rommereim LM, Guevara RB, Bzik DJ. Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity. Plos Genetics. 12: e1006189. PMID 27447180 DOI: 10.1371/Journal.Pgen.1006189  0.482
2016 Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ. The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection. Mbio. 7. PMID 27165797 DOI: 10.1128/Mbio.00193-16  0.49
2016 Sanders KL, Fox BA, Bzik DJ. Attenuated Toxoplasma gondii therapy of disseminated pancreatic cancer generates long-lasting immunity to pancreatic cancer. Oncoimmunology. 5: e1104447. PMID 27141388 DOI: 10.1080/2162402X.2015.1104447  0.359
2016 Bzik DJ. Serial Dissection of Parasite Gene Families. Infection and Immunity. PMID 26953326 DOI: 10.1128/Iai.00175-16  0.369
2015 Lopez J, Bittame A, Massera C, Vasseur V, Effantin G, Valat A, Buaillon C, Allart S, Fox BA, Rommereim LM, Bzik DJ, Schoehn G, Weissenhorn W, Dubremetz JF, Gagnon J, et al. Intravacuolar Membranes Regulate CD8 T Cell Recognition of Membrane-Bound Toxoplasma gondii Protective Antigen. Cell Reports. PMID 26628378 DOI: 10.1016/J.Celrep.2015.11.001  0.404
2015 Leroux LP, Nishi M, El-Hage S, Fox BA, Bzik DJ, Dzierszinski FS. Parasite manipulation of the invariant chain (Ii/CD74) and the peptide editor H2-DM affects MHC-II antigen presentation during Toxoplasma gondii infection. Infection and Immunity. PMID 26195549 DOI: 10.1128/Iai.00415-15  0.467
2015 Fox BA, Bzik DJ. Nonreplicating, cyst-defective type II Toxoplasma gondii vaccine strains stimulate protective immunity against acute and chronic infection. Infection and Immunity. 83: 2148-55. PMID 25776745 DOI: 10.1128/IAI.02756-14  0.32
2015 Leroux LP, Dasanayake D, Rommereim LM, Fox BA, Bzik DJ, Jardim A, Dzierszinski FS. Secreted Toxoplasma gondii molecules interfere with expression of MHC-II in interferon gamma-activated macrophages. International Journal For Parasitology. 45: 319-32. PMID 25720921 DOI: 10.1016/j.ijpara.2015.01.003  0.343
2015 Sanders KL, Fox BA, Bzik DJ. Abstract A103: Intracellular immunotherapy of disseminated pancreatic cancer activates potent IFNγ and CD8+ T cell dependent anti-tumor responses Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A103  0.394
2014 Zhao Y, Marple AH, Ferguson DJ, Bzik DJ, Yap GS. Avirulent strains of Toxoplasma gondii infect macrophages by active invasion from the phagosome. Proceedings of the National Academy of Sciences of the United States of America. 111: 6437-42. PMID 24733931 DOI: 10.1073/Pnas.1316841111  0.457
2013 Fox BA, Sanders KL, Chen S, Bzik DJ. Targeting tumors with nonreplicating Toxoplasma gondii uracil auxotroph vaccines. Trends in Parasitology. 29: 431-7. PMID 23928100 DOI: 10.1016/j.pt.2013.07.001  0.386
2013 Rommereim LM, Hortua Triana MA, Falla A, Sanders KL, Guevara RB, Bzik DJ, Fox BA. Genetic manipulation in Δku80 strains for functional genomic analysis of Toxoplasma gondii. Journal of Visualized Experiments : Jove. e50598. PMID 23892917 DOI: 10.3791/50598  0.396
2013 Baird JR, Fox BA, Sanders KL, Lizotte PH, Cubillos-Ruiz JR, Scarlett UK, Rutkowski MR, Conejo-Garcia JR, Fiering S, Bzik DJ. Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. Cancer Research. 73: 3842-51. PMID 23704211 DOI: 10.1158/0008-5472.Can-12-1974  0.424
2013 Baird JR, Byrne KT, Lizotte PH, Toraya-Brown S, Scarlett UK, Alexander MP, Sheen MR, Fox BA, Bzik DJ, Bosenberg M, Mullins DW, Turk MJ, Fiering S. Immune-mediated regression of established B16F10 melanoma by intratumoral injection of attenuated Toxoplasma gondii protects against rechallenge. Journal of Immunology (Baltimore, Md. : 1950). 190: 469-78. PMID 23225891 DOI: 10.4049/Jimmunol.1201209  0.428
2013 Fiering S, Baird JR, Fox B, Lizotte P, Sanders K, Conjeo-Garcia J, Bzik D. Abstract B21: Immune-based treatment of ovarian cancer in a mouse model with attenuated Toxoplasma gondii. Cancer Research. 73. DOI: 10.1158/1538-7445.Tumimm2012-B21  0.349
2012 Hortua Triana MA, Huynh MH, Garavito MF, Fox BA, Bzik DJ, Carruthers VB, Löffler M, Zimmermann BH. Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii. Molecular and Biochemical Parasitology. 184: 71-81. PMID 22580100 DOI: 10.1016/J.Molbiopara.2012.04.009  0.37
2012 Denkers EY, Bzik DJ, Fox BA, Butcher BA. An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii. Infection and Immunity. 80: 476-82. PMID 22104110 DOI: 10.1128/Iai.05974-11  0.382
2011 Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY. Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control. Plos Pathogens. 7: e1002236. PMID 21931552 DOI: 10.1371/Journal.Ppat.1002236  0.463
2011 Fox BA, Falla A, Rommereim LM, Tomita T, Gigley JP, Mercier C, Cesbron-Delauw MF, Weiss LM, Bzik DJ. Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection. Eukaryotic Cell. 10: 1193-206. PMID 21531875 DOI: 10.1128/Ec.00297-10  0.728
2010 Fentress SJ, Behnke MS, Dunay IR, Mashayekhi M, Rommereim LM, Fox BA, Bzik DJ, Taylor GA, Turk BE, Lichti CF, Townsend RR, Qiu W, Hui R, Beatty WL, Sibley LD. Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence. Cell Host & Microbe. 8: 484-95. PMID 21147463 DOI: 10.1016/J.Chom.2010.11.005  0.385
2010 Fox BA, Bzik DJ. Avirulent uracil auxotrophs based on disruption of orotidine-5'-monophosphate decarboxylase elicit protective immunity to Toxoplasma gondii. Infection and Immunity. 78: 3744-52. PMID 20605980 DOI: 10.1128/Iai.00287-10  0.393
2010 Charles E, Joshi S, Ash JD, Fox BA, Farris AD, Bzik DJ, Lang ML, Blader IJ. CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1. Infection and Immunity. 78: 3484-92. PMID 20498261 DOI: 10.1128/Iai.00117-10  0.388
2009 Gigley JP, Fox BA, Bzik DJ. Long-term immunity to lethal acute or chronic type II Toxoplasma gondii infection is effectively induced in genetically susceptible C57BL/6 mice by immunization with an attenuated type I vaccine strain. Infection and Immunity. 77: 5380-8. PMID 19797073 DOI: 10.1128/Iai.00649-09  0.701
2009 Jordan KA, Wilson EH, Tait ED, Fox BA, Roos DS, Bzik DJ, Dzierszinski F, Hunter CA. Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii. Infection and Immunity. 77: 3894-901. PMID 19528214 DOI: 10.1128/Iai.00024-09  0.465
2009 Fox BA, Ristuccia JG, Gigley JP, Bzik DJ. Efficient gene replacements in Toxoplasma gondii strains deficient for nonhomologous end joining. Eukaryotic Cell. 8: 520-9. PMID 19218423 DOI: 10.1128/Ec.00357-08  0.684
2009 Gigley JP, Fox BA, Bzik DJ. Cell-mediated immunity to Toxoplasma gondii develops primarily by local Th1 host immune responses in the absence of parasite replication. Journal of Immunology (Baltimore, Md. : 1950). 182: 1069-78. PMID 19124750 DOI: 10.4049/Jimmunol.182.2.1069  0.724
2009 Fox BA, Ristuccia JG, Bzik DJ. Genetic identification of essential indels and domains in carbamoyl phosphate synthetase II of Toxoplasma gondii. International Journal For Parasitology. 39: 533-9. PMID 18992249 DOI: 10.1016/J.Ijpara.2008.09.011  0.42
2008 Sukhumavasi W, Egan CE, Warren AL, Taylor GA, Fox BA, Bzik DJ, Denkers EY. TLR adaptor MyD88 is essential for pathogen control during oral toxoplasma gondii infection but not adaptive immunity induced by a vaccine strain of the parasite. Journal of Immunology (Baltimore, Md. : 1950). 181: 3464-73. PMID 18714019 DOI: 10.4049/Jimmunol.181.5.3464  0.5
2007 Guan H, Moretto M, Bzik DJ, Gigley J, Khan IA. NK cells enhance dendritic cell response against parasite antigens via NKG2D pathway. Journal of Immunology (Baltimore, Md. : 1950). 179: 590-6. PMID 17579080 DOI: 10.4049/Jimmunol.179.1.590  0.704
2006 Shaw MH, Freeman GJ, Scott MF, Fox BA, Bzik DJ, Belkaid Y, Yap GS. Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. Journal of Immunology (Baltimore, Md. : 1950). 176: 7263-71. PMID 16751369 DOI: 10.4049/Jimmunol.176.12.7263  0.361
2006 Combe CL, Moretto MM, Schwartzman JD, Gigley JP, Bzik DJ, Khan IA. Lack of IL-15 results in the suboptimal priming of CD4+ T cell response against an intracellular parasite. Proceedings of the National Academy of Sciences of the United States of America. 103: 6635-40. PMID 16614074 DOI: 10.1073/Pnas.0506180103  0.701
2004 Fox BA, Gigley JP, Bzik DJ. Toxoplasma gondii lacks the enzymes required for de novo arginine biosynthesis and arginine starvation triggers cyst formation. International Journal For Parasitology. 34: 323-31. PMID 15003493 DOI: 10.1016/J.Ijpara.2003.12.001  0.712
2003 Fox BA, Bzik DJ. Organisation and sequence determination of glutamine-dependent carbamoyl phosphate synthetase II in Toxoplasma gondii. International Journal For Parasitology. 33: 89-96. PMID 12547350 DOI: 10.1016/S0020-7519(02)00214-X  0.331
2002 Fox BA, Horii T, Bzik DJ. Plasmodium falciparum: fine-mapping of an epitope of the serine repeat antigen that is a target of parasite-inhibitory antibodies. Experimental Parasitology. 101: 69-72. PMID 12243740 DOI: 10.1016/S0014-4894(02)00034-6  0.33
2002 Fox BA, Bzik DJ. De novo pyrimidine biosynthesis is required for virulence of Toxoplasma gondii. Nature. 415: 926-9. PMID 11859373 DOI: 10.1038/415926A  0.48
2001 Pfefferkorn ER, Bzik DJ, Honsinger CP. Toxoplasma gondii: mechanism of the parasitostatic action of 6-thioxanthine. Experimental Parasitology. 99: 235-43. PMID 11888251 DOI: 10.1006/Expr.2001.4673  0.381
2001 Belperron AA, Fox BA, Horii T, Bzik DJ. Toxoplasma gondii: Genetic selection of tethered dihydrofolate reductase-thymidylate synthase fusion proteins Experimental Parasitology. 98: 167-170. PMID 11527440 DOI: 10.1006/Expr.2001.4631  0.303
2000 Ngô HM, Ngo EO, Bzik DJ, Joiner KA. Toxoplasma gondii: Are host cell adenosine nucleotides a direct source for purine salvage? Experimental Parasitology. 95: 148-153. PMID 10910717 DOI: 10.1006/Expr.2000.4519  0.31
2000 Fox BA, Bzik DJ. Genetic analysis of de novo pyrimidine synthesis in Toxoplasma gondii: Construction of pyrimidine auxotroph mutants in parasitic protozoa Biochemical Society Transactions. 28: A479-A479. DOI: 10.1042/Bst028A479B  0.352
1999 Belperron AA, Feltquate D, Fox BA, Horii T, Bzik DJ. Immune responses induced by Gene Gun or intramuscular injection of DNA vaccines that express immunogenic regions of the serine repeat antigen from Plasmodium falciparum Infection and Immunity. 67: 5163-5169. PMID 10496891 DOI: 10.1128/Iai.67.10.5163-5169.1999  0.376
1999 Fox BA, Belperron AA, Bzik DJ. Stable transformation of Toxoplasma gondii based on a pyrimethamine resistant trifunctional dihydrofolate reductase-cytosine deaminase-thymidylate synthase gene that confers sensitivity to 5-fluorocytosine Molecular and Biochemical Parasitology. 98: 93-103. PMID 10029312 DOI: 10.1016/S0166-6851(98)00154-6  0.304
1997 Morimatsu K, Morikawa T, Tanabe K, Bzik DJ, Horii T. Sequence diversity in the amino-terminal 47 kDA fragment of the Plasmodium falciparum serine repeat antigen Molecular and Biochemical Parasitology. 86: 249-254. PMID 9200130 DOI: 10.1016/S0166-6851(97)00038-8  0.3
1997 Fox BA, Xing-Li P, Suzue K, Horii T, Bzik DJ. Plasmodium falciparum: An epitope within a highly conserved region of the 47-kDa amino-terminal domain of the serine repeat antigen is a target of parasite-inhibitory antibodies Experimental Parasitology. 85: 121-134. PMID 9030663 DOI: 10.1006/Expr.1996.4118  0.394
1994 Fox BA, Bzik DJ. Analysis of stage-specific transcripts of the Plasmodium falciparum serine repeat antigen (SERA) gene and transcription from the SERA locus Molecular and Biochemical Parasitology. 68: 133-144. PMID 7891737 DOI: 10.1016/0166-6851(94)00162-6  0.305
1993 Bzik DJ, Fox BA, Gonyer K. Expression of Plasmodium falciparum lactate dehydrogenase in Escherichia coli Molecular and Biochemical Parasitology. 59: 155-166. PMID 8515777 DOI: 10.1016/0166-6851(93)90016-Q  0.306
1993 Fox BA, Li WB, Tanaka M, Inselburg J, Bzik DJ. Molecular characterization of the largest subunit of Plasmodium falciparum RNA polymerase I Molecular and Biochemical Parasitology. 61: 37-48. PMID 8259131 DOI: 10.1016/0166-6851(93)90156-R  0.306
1992 Bzik DJ, Peck JY, Fox BA. Mung bean nuclease exhibits an exon-excision activity upon the Plasmodium falciparum SERA gene Molecular and Biochemical Parasitology. 56: 185-188. PMID 1474998 DOI: 10.1016/0166-6851(92)90167-I  0.33
1991 Barr PJ, Inselburg J, Green KM, Kansopon J, Hahm BK, Gibson HL, Lee-Ng CT, Bzik DJ, Li Wb, Bathurst IC. Immunogenicity of recombinant Plasmodium falciparum SERA proteins in rodents Molecular and Biochemical Parasitology. 45: 159-170. PMID 2052035 DOI: 10.1016/0166-6851(91)90038-8  0.418
1991 Inselburg J, Bzik DJ, Li WB, Green KM, Kansopon J, Hahm BK, Bathurst IC, Barr PJ, Rossan RN. Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum Infection and Immunity. 59: 1247-1250. PMID 1900809 DOI: 10.1128/Iai.59.4.1247-1250.1991  0.376
1991 Li WB, Bzik DJ, Tanaka M, Gu H, Fox BA, Inselburg J. Characterization of the gene encoding the largest subunit of Plasmodium falciparum RNA polymerase III Molecular and Biochemical Parasitology. 46: 229-239. PMID 1656254 DOI: 10.1016/0166-6851(91)90047-A  0.318
1990 Tanaka M, Gu HM, Bzik DJ, Li WB, Inselburg J. Mutant dihydrofolate reductase-thymidylate synthase genes in pyrimethamine-resistant Plasmodium falciparum with polymorphic chromosome duplications Molecular and Biochemical Parasitology. 42: 83-91. PMID 2233901 DOI: 10.1016/0166-6851(90)90115-3  0.31
1989 Li WB, Bzik DJ, Gu H, Tanaka M, Fox BA, Inselburg J. An enlarged largest subunit or Plasmodium falciparum RNA polymerase II defines conserved and variable RNA polymerase domains Nucleic Acids Research. 17: 9621-9636. PMID 2690004 DOI: 10.1093/Nar/17.23.9621  0.312
1989 Li WB, Bzik DJ, Horii T, Inselburg J. Structure and expression of the Plasmodium falciparum SERA gene Molecular and Biochemical Parasitology. 33: 13-25. PMID 2651911 DOI: 10.1016/0166-6851(89)90037-6  0.361
1988 Bzik DJ, Li Wb, Horii T, Inselburg J. Amino acid sequence of the serine-repeat antigen (SERA) of Plasmodium falciparum determined from cloned cDNA Molecular and Biochemical Parasitology. 30: 279-288. PMID 2847041 DOI: 10.1016/0166-6851(88)90097-7  0.379
1988 Horii T, Bzik DJ, Inselburg J. Characterization of antigen-expressing Plasmodium falciparum cDNA clones that are reactive with parasite inhibitory antibodies Molecular and Biochemical Parasitology. 30: 9-18. PMID 2456465 DOI: 10.1016/0166-6851(88)90127-2  0.378
1987 Inselburg J, Bzik DJ, Horii T. Pyrimethamine resistant Plasmodium falciparum: overproduction of dihydrofolate reductase by a gene duplication Molecular and Biochemical Parasitology. 26: 121-134. PMID 3323903 DOI: 10.1016/0166-6851(87)90136-8  0.369
1987 Bzik DJ, Li WB, Horii T, Inselburg J. Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene Proceedings of the National Academy of Sciences of the United States of America. 84: 8360-8364. PMID 2825189 DOI: 10.1073/Pnas.84.23.8360  0.31
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