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Florian Holsboer - Publications

Affiliations: 
MPIP Munich, München, Bayern, Germany 
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Year Citation  Score
2020 Barakat AK, Scholl C, Steffens M, Brandenburg K, Ising M, Lucae S, Holsboer F, Laje G, Kalayda GV, Jaehde U, Stingl JC. Citalopram-induced pathways regulation and tentative treatment-outcome-predicting biomarkers in lymphoblastoid cell lines from depression patients. Translational Psychiatry. 10: 210. PMID 32612257 DOI: 10.1038/S41398-020-00900-8  0.332
2020 von Känel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M. Acute Stress-Induced Coagulation Activation in Patients With Remitted Major Depression Versus Healthy Controls and the Role of Stress-Specific Coping. Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine. PMID 32044917 DOI: 10.1093/Abm/Kaaa001  0.336
2019 von Känel R, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Höhne N, Ising M. Evidence for an enhanced procoagulant state in remitted major depression. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1-25. PMID 31755344 DOI: 10.1080/15622975.2019.1696475  0.335
2019 Hennings JM, Kohli MA, Uhr M, Holsboer F, Ising M, Lucae S. Polymorphisms in the BDNF and BDNFOS genes are associated with hypothalamus-pituitary axis regulation in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109686. PMID 31295515 DOI: 10.1016/J.Pnpbp.2019.109686  0.351
2019 Ising M, Maccarrone G, Brückl T, Scheuer S, Hennings J, Holsboer F, Turck CW, Uhr M, Lucae S. FKBP5 Gene Expression Predicts Antidepressant Treatment Outcome in Depression. International Journal of Molecular Sciences. 20. PMID 30678080 DOI: 10.3390/Ijms20030485  0.394
2018 Inkster B, Simmons A, Cole J, Schoof E, Linding R, Nichols T, Muglia P, Holsboer F, Saemann P, McGuffin P, Fu C, Miskowiak K, Matthews PM, Zai G, Nicodemus K. Unravelling the GSK3β-related genotypic interaction network influencing hippocampal volume in recurrent major depressive disorder. Psychiatric Genetics. PMID 30080747 DOI: 10.1097/Ypg.0000000000000203  0.324
2018 Scheuer S, Wiggert N, Brückl TM, Awaloff Y, Uhr M, Lucae S, Kloiber S, Holsboer F, Ising M, Wilhelm FH. Childhood abuse and depression in adulthood: The mediating role of allostatic load. Psychoneuroendocrinology. 94: 134-142. PMID 29775876 DOI: 10.1016/J.Psyneuen.2018.04.020  0.311
2018 Naik RR, Sotnikov SV, Diepold RP, Iurato S, Markt PO, Bultmann A, Brehm N, Mattheus T, Lutz B, Erhardt A, Binder EB, Schmidt U, Holsboer F, Landgraf R, Czibere L. Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Translational Psychiatry. 8: 1. PMID 29317594 DOI: 10.1038/S41398-017-0025-2  0.314
2017 Carrillo-Roa T, Labermaier C, Weber P, Herzog DP, Lareau C, Santarelli S, Wagner KV, Rex-Haffner M, Harbich D, Scharf SH, Nemeroff CB, Dunlop BW, Craighead WE, Mayberg HS, Schmidt MV, ... ... Holsboer F, et al. Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity. Plos Biology. 15: e2002690. PMID 29283992 DOI: 10.1371/Journal.Pbio.2002690  0.34
2017 Metzger MW, Walser SM, Dedic N, Aprile-Garcia F, Jakubcakova V, Adamczyk M, Webb KJ, Uhr M, Refojo D, Schmidt MV, Friess E, Steiger A, Kimura M, Chen A, Holsboer F, et al. Heterozygosity for the mood disorder-associated variant Gln460Arg alters P2X7 receptor function and sleep quality. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29079688 DOI: 10.1523/Jneurosci.3487-16.2017  0.35
2017 Turck CW, Guest PC, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Martins-de-Souza D. Proteomic Differences in Blood Plasma Associated with Antidepressant Treatment Response. Frontiers in Molecular Neuroscience. 10: 272. PMID 28912679 DOI: 10.3389/Fnmol.2017.00272  0.306
2017 Pawlowski MA, Gazea M, Wollweber B, Dresler M, Holsboer F, Keck ME, Steiger A, Adamczyk M, Mikoteit T. Heart rate variability and cordance in rapid eye movement sleep as biomarkers of depression and treatment response. Journal of Psychiatric Research. 92: 64-73. PMID 28411417 DOI: 10.1016/J.Jpsychires.2017.03.026  0.308
2017 Holsboer-Trachsler E, Breitenstein B, Kirmeier T, Holsboer F. Genetic Variants in the ABCB1 Gene Determine Bioavailability of Antidepressants in the Brain European Psychiatry. 41: s238-s238. DOI: 10.1016/J.Eurpsy.2017.02.002  0.311
2016 Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM. Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signalling. PMID 27858314 DOI: 10.1007/S11302-016-9546-Z  0.305
2016 Breitfeld J, Scholl C, Steffens M, Brandenburg K, Probst-Schendzielorz K, Efimkina O, Gurwitz D, Ising M, Holsboer F, Lucae S, Stingl JC. Proliferation rates and gene expression profiles in human lymphoblastoid cell lines from patients with depression characterized in response to antidepressant drug therapy. Translational Psychiatry. 6: e950. PMID 27845776 DOI: 10.1038/Tp.2016.185  0.328
2016 Deuschle M, Gotthardt U, Schweiger U, Dettling M, Holsboer F, Heuser I. Hypothalamus - Pituitary - Adrenocortical Dysfunction in Elderly, Male Marathon Runners: Feedback Sensitivity, Stress Response and Effects on Verbal Memory. Neuroendocrinology. PMID 27677093 DOI: 10.1159/000450856  0.329
2015 Stepan J, Hladky F, Uribe A, Holsboer F, Schmidt MV, Eder M. High-Speed imaging reveals opposing effects of chronic stress and antidepressants on neuronal activity propagation through the hippocampal trisynaptic circuit. Frontiers in Neural Circuits. 9: 70. PMID 26594153 DOI: 10.3389/Fncir.2015.00070  0.305
2015 Santarelli S, Wagner KV, Labermaier C, Uribe A, Dournes C, Balsevich G, Hartmann J, Masana M, Holsboer F, Chen A, Müller MB, Schmidt MV. SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress (Amsterdam, Netherlands). 1-8. PMID 26585320 DOI: 10.3109/10253890.2015.1105211  0.394
2015 Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB. Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation. Biological Psychiatry. PMID 26410355 DOI: 10.1016/J.Biopsych.2015.08.005  0.582
2015 Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, ... Holsboer F, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9007-16. PMID 26085626 DOI: 10.1523/Jneurosci.4024-14.2015  0.339
2015 Rucker JJ, Tansey KE, Rivera M, Pinto D, Cohen-Woods S, Uher R, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, Barnes MR, Preisig M, Mors O, ... ... Holsboer F, et al. Phenotypic Association Analyses with Copy Number Variation in Recurrent Depressive Disorder. Biological Psychiatry. PMID 25861698 DOI: 10.1016/J.Biopsych.2015.02.025  0.323
2015 Kopczak A, Stalla GK, Uhr M, Lucae S, Hennings J, Ising M, Holsboer F, Kloiber S. IGF-I in major depression and antidepressant treatment response. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 25: 864-72. PMID 25836355 DOI: 10.1016/J.Euroneuro.2014.12.013  0.344
2015 Dine J, Ionescu IA, Avrabos C, Yen YC, Holsboer F, Landgraf R, Schmidt U, Eder M. Intranasally applied neuropeptide S shifts a high-anxiety electrophysiological endophenotype in the ventral hippocampus towards a "normal"-anxiety one. Plos One. 10: e0120272. PMID 25830625 DOI: 10.1371/Journal.Pone.0120272  0.325
2015 Hennings JM, Uhr M, Klengel T, Weber P, Pütz B, Touma C, Czamara D, Ising M, Holsboer F, Lucae S. RNA expression profiling in depressed patients suggests retinoid-related orphan receptor alpha as a biomarker for antidepressant response. Translational Psychiatry. 5: e538. PMID 25826113 DOI: 10.1016/J.Eurpsy.2016.01.394  0.332
2015 Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OF, Spengler D. Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress. Epigenetics : Official Journal of the Dna Methylation Society. 10: 247-57. PMID 25793778 DOI: 10.1080/15592294.2015.1017199  0.34
2015 Adamczyk M, Gazea M, Wollweber B, Holsboer F, Dresler M, Steiger A, Pawlowski M. Cordance derived from REM sleep EEG as a biomarker for treatment response in depression--a naturalistic study after antidepressant medication. Journal of Psychiatric Research. 63: 97-104. PMID 25772006 DOI: 10.1016/J.Jpsychires.2015.02.007  0.329
2015 Zaba M, Kirmeier T, Ionescu IA, Wollweber B, Buell DR, Gall-Kleebach DJ, Schubert CF, Novak B, Huber C, Köhler K, Holsboer F, Pütz B, Müller-Myhsok B, Höhne N, Uhr M, et al. Identification and characterization of HPA-axis reactivity endophenotypes in a cohort of female PTSD patients. Psychoneuroendocrinology. 55: 102-15. PMID 25745955 DOI: 10.1016/J.Psyneuen.2015.02.005  0.327
2015 Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM. Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology. 53: 16-28. PMID 25575243 DOI: 10.1016/J.Psyneuen.2014.12.005  0.363
2015 Höhne N, Poidinger M, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Ising M. FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522420 DOI: 10.1093/Ijnp/Pyu087  0.356
2015 Schmidt U, Buell DR, Ionescu IA, Gassen NC, Holsboer F, Cox MB, Novak B, Huber C, Hartmann J, Schmidt MV, Touma C, Rein T, Herrmann L. A role for synapsin in FKBP51 modulation of stress responsiveness: Convergent evidence from animal and human studies. Psychoneuroendocrinology. 52: 43-58. PMID 25459892 DOI: 10.1016/J.Psyneuen.2014.11.005  0.341
2015 Elbau I, Ising M, Uhr M, Schaaf L, Holsboer F, Lucae S, Kloiber S. Thyroid disorders are associated with impaired response to psychopharmacological treatment of major depression Pharmacopsychiatry. 48. DOI: 10.1055/S-0035-1557948  0.324
2014 Gassen NC, Hartmann J, Zschocke J, Stepan J, Hafner K, Zellner A, Kirmeier T, Kollmannsberger L, Wagner KV, Dedic N, Balsevich G, Deussing JM, Kloiber S, Lucae S, Holsboer F, et al. Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans. Plos Medicine. 11: e1001755. PMID 25386878 DOI: 10.1371/Journal.Pmed.1001755  0.393
2014 Höhne N, Poidinger M, Merz F, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Ising M. Increased HPA axis response to psychosocial stress in remitted depression: the influence of coping style. Biological Psychology. 103: 267-75. PMID 25263610 DOI: 10.1016/J.Biopsycho.2014.09.008  0.362
2014 Heinzmann JM, Kloiber S, Ebling-Mattos G, Bielohuby M, Schmidt MV, Palme R, Holsboer F, Uhr M, Ising M, Touma C. Mice selected for extremes in stress reactivity reveal key endophenotypes of major depression: a translational approach. Psychoneuroendocrinology. 49: 229-43. PMID 25123105 DOI: 10.1055/S-0035-1547627  0.409
2014 Labermaier C, Kohl C, Hartmann J, Devigny C, Altmann A, Weber P, Arloth J, Quast C, Wagner KV, Scharf SH, Czibere L, Widner-Andrä R, Brenndörfer J, Landgraf R, Hausch F, ... ... Holsboer F, et al. A polymorphism in the Crhr1 gene determines stress vulnerability in male mice. Endocrinology. 155: 2500-10. PMID 24773341 DOI: 10.1210/En.2013-1986  0.337
2014 Menke A, Arloth J, Gerber M, Rex-Haffner M, Uhr M, Holsboer F, Binder EB, Holsboer-Trachsler E, Beck J. Dexamethasone stimulated gene expression in peripheral blood indicates glucocorticoid-receptor hypersensitivity in job-related exhaustion. Psychoneuroendocrinology. 44: 35-46. PMID 24767618 DOI: 10.1055/S-0033-1353309  0.306
2014 Santarelli S, Lesuis SL, Wang XD, Wagner KV, Hartmann J, Labermaier C, Scharf SH, Müller MB, Holsboer F, Schmidt MV. Evidence supporting the match/mismatch hypothesis of psychiatric disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 907-18. PMID 24589292 DOI: 10.1016/J.Euroneuro.2014.02.002  0.334
2014 Breitenstein B, Scheuer S, Holsboer F. Are there meaningful biomarkers of treatment response for depression? Drug Discovery Today. 19: 539-61. PMID 24561326 DOI: 10.1016/J.Drudis.2014.02.002  0.337
2014 Sotnikov SV, Markt PO, Malik V, Chekmareva NY, Naik RR, Sah A, Singewald N, Holsboer F, Czibere L, Landgraf R. Bidirectional rescue of extreme genetic predispositions to anxiety: impact of CRH receptor 1 as epigenetic plasticity gene in the amygdala. Translational Psychiatry. 4: e359. PMID 24518397 DOI: 10.1038/Tp.2013.127  0.328
2014 Martins-de-Souza D, Maccarrone G, Ising M, Kloiber S, Lucae S, Holsboer F, Turck CW. Plasma fibrinogen: now also an antidepressant response marker? Translational Psychiatry. 4: e352. PMID 24473443 DOI: 10.1038/Tp.2013.129  0.318
2014 Albu S, Romanowski CP, Letizia Curzi M, Jakubcakova V, Flachskamm C, Gassen NC, Hartmann J, Schmidt MV, Schmidt U, Rein T, Holsboer F, Hausch F, Paez-Pereda M, Kimura M. Deficiency of FK506-binding protein (FKBP) 51 alters sleep architecture and recovery sleep responses to stress in mice. Journal of Sleep Research. 23: 176-85. PMID 24354785 DOI: 10.1111/Jsr.12112  0.344
2014 Breitenstein B, Scheuer S, Pfister H, Uhr M, Lucae S, Holsboer F, Ising M, Brückl TM. The clinical application of ABCB1 genotyping in antidepressant treatment: a pilot study. Cns Spectrums. 19: 165-75. PMID 23880209 DOI: 10.1017/S1092852913000436  0.312
2013 Avrabos C, Sotnikov SV, Dine J, Markt PO, Holsboer F, Landgraf R, Eder M. Real-time imaging of amygdalar network dynamics in vitro reveals a neurophysiological link to behavior in a mouse model of extremes in trait anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16262-7. PMID 24107957 DOI: 10.1523/Jneurosci.2397-13.2013  0.313
2013 Maccarrone G, Ditzen C, Yassouridis A, Rewerts C, Uhr M, Uhlen M, Holsboer F, Turck CW. Psychiatric patient stratification using biosignatures based on cerebrospinal fluid protein expression clusters. Journal of Psychiatric Research. 47: 1572-80. PMID 23962679 DOI: 10.1016/J.Jpsychires.2013.07.021  0.308
2013 Sämann PG, Höhn D, Chechko N, Kloiber S, Lucae S, Ising M, Holsboer F, Czisch M. Prediction of antidepressant treatment response from gray matter volume across diagnostic categories. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1503-15. PMID 23920122 DOI: 10.1016/J.Euroneuro.2013.07.004  0.328
2013 Wang XD, Su YA, Wagner KV, Avrabos C, Scharf SH, Hartmann J, Wolf M, Liebl C, Kühne C, Wurst W, Holsboer F, Eder M, Deussing JM, Müller MB, Schmidt MV. Nectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss. Nature Neuroscience. 16: 706-13. PMID 23644483 DOI: 10.1038/Nn.3395  0.307
2013 Wagner KV, Hartmann J, Mangold K, Wang XD, Labermaier C, Liebl C, Wolf M, Gassen NC, Holsboer F, Rein T, Müller MB, Schmidt MV. Homer1 mediates acute stress-induced cognitive deficits in the dorsal hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 3857-64. PMID 23447597 DOI: 10.1523/Jneurosci.4333-12.2013  0.308
2013 Menke A, Klengel T, Rubel J, Brückl T, Pfister H, Lucae S, Uhr M, Holsboer F, Binder EB. Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression. Genes, Brain, and Behavior. 12: 289-96. PMID 23406438 DOI: 10.1111/Gbb.12026  0.379
2013 Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neuroscience. 16: 33-41. PMID 23201972 DOI: 10.1038/Nn.3275  0.333
2013 Kloiber S, Ripke S, Kohli MA, Reppermund S, Salyakina D, Uher R, McGuffin P, Perlis RH, Hamilton SP, Pütz B, Hennings J, Brückl T, Klengel T, Bettecken T, Ising M, ... ... Holsboer F, et al. Resistance to antidepressant treatment is associated with polymorphisms in the leptin gene, decreased leptin mRNA expression, and decreased leptin serum levels. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 653-62. PMID 23026132 DOI: 10.1016/J.Euroneuro.2012.08.010  0.361
2013 Rucker JJ, Breen G, Pinto D, Pedroso I, Lewis CM, Cohen-Woods S, Uher R, Schosser A, Rivera M, Aitchison KJ, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, ... ... Holsboer F, et al. Genome-wide association analysis of copy number variation in recurrent depressive disorder. Molecular Psychiatry. 18: 183-9. PMID 22042228 DOI: 10.1038/Mp.2011.144  0.302
2013 Uher R, Tansey KE, Rietschel M, Henigsberg N, Maier W, Mors O, Hauser J, Placentino A, Souery D, Farmer A, Aitchison KJ, Craig I, McGuffin P, Lewis CM, Ising M, ... ... Holsboer F, et al. Common genetic variation and antidepressant efficacy in major depressive disorder: A meta-analysis of three genome-wide pharmacogenetic studies American Journal of Psychiatry. 170: 207-217. DOI: 10.1176/Appi.Ajp.2012.12020237  0.336
2013 Kopczak A, Stalla G, Uhr M, Lucae S, Hennings J, Holsboer F, Kloiber S. IGF-1 is elevated in patients with depression and non-remitters to antidepressant treatment Experimental and Clinical Endocrinology & Diabetes. 121. DOI: 10.1055/S-0033-1359446  0.323
2013 Erhardt A, Lucae S, Ising M, Holsboer F, Binder E. Association of PACAP and PACAPR1 gene variants with unipolar depression and panic disorder Pharmacopsychiatry. 46. DOI: 10.1055/S-0033-1353350  0.33
2013 Pawlowski M, Gazea M, Adamczyk M, Wollweber B, Holsboer F, Steiger A, Dresler M. Cordance as a biomarker in sleep-EEG for treatment response in depression Pharmacopsychiatry. 46. DOI: 10.1055/S-0033-1353284  0.334
2013 Nakano W, Mehta D, Ising M, Pfister H, Czamara D, Holsboer F, Lucae S, Erhardt-Lehmann A, Binder E. P.2.b.010 Genetic predictor of antidepressant response for major depressive disorder: a genome-wide association study and pathway analysis European Neuropsychopharmacology. 23: S324-S325. DOI: 10.1016/S0924-977X(13)70509-1  0.319
2012 Gonik M, Frank E, Keßler MS, Czamara D, Bunck M, Yen YC, Pütz B, Holsboer F, Bettecken T, Landgraf R, Müller-Myhsok B, Touma C, Czibere L. The endocrine stress response is linked to one specific locus on chromosome 3 in a mouse model based on extremes in trait anxiety. Bmc Genomics. 13: 579. PMID 23114097 DOI: 10.1186/1471-2164-13-579  0.368
2012 Ganea K, Menke A, Schmidt MV, Lucae S, Rammes G, Liebl C, Harbich D, Sterlemann V, Storch C, Uhr M, Holsboer F, Binder EB, Sillaber I, Müller MB. Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response. Translational Psychiatry. 2: e177. PMID 23092981 DOI: 10.1038/Tp.2012.104  0.363
2012 Wagner KV, Marinescu D, Hartmann J, Wang XD, Labermaier C, Scharf SH, Liebl C, Uhr M, Holsboer F, Müller MB, Schmidt MV. Differences in FKBP51 regulation following chronic social defeat stress correlate with individual stress sensitivity: influence of paroxetine treatment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2797-808. PMID 22871917 DOI: 10.1038/Npp.2012.150  0.34
2012 Wang XD, Labermaier C, Holsboer F, Wurst W, Deussing JM, Müller MB, Schmidt MV. Early-life stress-induced anxiety-related behavior in adult mice partially requires forebrain corticotropin-releasing hormone receptor 1. The European Journal of Neuroscience. 36: 2360-7. PMID 22672268 DOI: 10.1111/J.1460-9568.2012.08148.X  0.327
2012 Graf C, Kuehne C, Panhuysen M, Puetz B, Weber P, Holsboer F, Wurst W, Deussing JM. Corticotropin-releasing hormone regulates common target genes with divergent functions in corticotrope and neuronal cells. Molecular and Cellular Endocrinology. 362: 29-38. PMID 22659651 DOI: 10.1016/J.Mce.2012.05.007  0.33
2012 Kloiber S, Czamara D, Karbalai N, Müller-Myhsok B, Hennings J, Holsboer F, Lucae S. ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. Journal of Psychiatric Research. 46: 973-9. PMID 22647524 DOI: 10.1016/J.Jpsychires.2012.04.017  0.307
2012 Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 37: 2009-21. PMID 22641006 DOI: 10.1016/J.Psyneuen.2012.04.017  0.371
2012 Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F. The prospect of FKBP51 as a drug target. Chemmedchem. 7: 1351-9. PMID 22581765 DOI: 10.1002/Cmdc.201200137  0.334
2012 Knapman A, Kaltwasser SF, Martins-de-Souza D, Holsboer F, Landgraf R, Turck CW, Czisch M, Touma C. Increased stress reactivity is associated with reduced hippocampal activity and neuronal integrity along with changes in energy metabolism. The European Journal of Neuroscience. 35: 412-22. PMID 22288479 DOI: 10.1111/J.1460-9568.2011.07968.X  0.323
2012 Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1455-64. PMID 22237309 DOI: 10.1038/Npp.2011.331  0.332
2012 Dedic N, Touma C, Romanowski CP, Schieven M, Kühne C, Ableitner M, Lu A, Holsboer F, Wurst W, Kimura M, Deussing JM. Assessing behavioural effects of chronic HPA axis activation using conditional CRH-overexpressing mice. Cellular and Molecular Neurobiology. 32: 815-28. PMID 22198557 DOI: 10.1007/S10571-011-9784-0  0.36
2012 Ditzen C, Tang N, Jastorff AM, Teplytska L, Yassouridis A, Maccarrone G, Uhr M, Bronisch T, Miller CA, Holsboer F, Turck CW. Cerebrospinal fluid biomarkers for major depression confirm relevance of associated pathophysiology. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1013-25. PMID 22169944 DOI: 10.1038/Npp.2011.285  0.336
2012 Thoeringer CK, Henes K, Eder M, Dahlhoff M, Wurst W, Holsboer F, Deussing JM, Moosmang S, Wotjak CT. Consolidation of remote fear memories involves Corticotropin-Releasing Hormone (CRH) receptor type 1-mediated enhancement of AMPA receptor GluR1 signaling in the dentate gyrus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 787-96. PMID 22030710 DOI: 10.1038/Npp.2011.256  0.308
2012 Menke A, Sämann P, Kloiber S, Czamara D, Lucae S, Hennings J, Heck A, Kohli MA, Czisch M, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes. Psychoneuroendocrinology. 37: 565-75. PMID 21962378 DOI: 10.1016/J.Psyneuen.2011.09.003  0.362
2012 Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 62: 332-9. PMID 21839098 DOI: 10.1016/J.Neuropharm.2011.07.041  0.387
2012 Höhne N, Pfister H, Brückl T, Zimmermann P, Uhr M, Holsboer F, Ising M. Effect of psychosocial stress on FKBP5 and NR3C1 gene expression in healthy young men European Journal of Psychotraumatology. 3: 19557. DOI: 10.3402/Ejpt.V3I0.19557  0.343
2011 Webhofer C, Gormanns P, Tolstikov V, Zieglgänsberger W, Sillaber I, Holsboer F, Turck CW. Metabolite profiling of antidepressant drug action reveals novel drug targets beyond monoamine elevation. Translational Psychiatry. 1: e58. PMID 22832350 DOI: 10.1038/Tp.2011.56  0.315
2011 Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry. 70: 928-36. PMID 21907973 DOI: 10.1016/J.Biopsych.2011.07.023  0.385
2011 Czibere L, Baur LA, Wittmann A, Gemmeke K, Steiner A, Weber P, Pütz B, Ahmad N, Bunck M, Graf C, Widner R, Kühne C, Panhuysen M, Hambsch B, Rieder G, ... ... Holsboer F, et al. Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice. Plos One. 6: e23604. PMID 21897848 DOI: 10.1371/Journal.Pone.0023604  0.337
2011 Refojo D, Schweizer M, Kuehne C, Ehrenberg S, Thoeringer C, Vogl AM, Dedic N, Schumacher M, von Wolff G, Avrabos C, Touma C, Engblom D, Schütz G, Nave KA, Eder M, ... ... Holsboer F, et al. Glutamatergic and dopaminergic neurons mediate anxiogenic and anxiolytic effects of CRHR1. Science (New York, N.Y.). 333: 1903-7. PMID 21885734 DOI: 10.1126/Science.1202107  0.313
2011 Zimmermann P, Brückl T, Nocon A, Pfister H, Binder EB, Uhr M, Lieb R, Moffitt TE, Caspi A, Holsboer F, Ising M. Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community study. The American Journal of Psychiatry. 168: 1107-16. PMID 21865530 DOI: 10.1176/Appi.Ajp.2011.10111577  0.352
2011 Zhang Y, Filiou MD, Reckow S, Gormanns P, Maccarrone G, Kessler MS, Frank E, Hambsch B, Holsboer F, Landgraf R, Turck CW. Proteomic and metabolomic profiling of a trait anxiety mouse model implicate affected pathways. Molecular & Cellular Proteomics : McP. 10: M111.008110. PMID 21862759 DOI: 10.1074/Mcp.M111.008110  0.324
2011 Denk MC, Rewerts C, Holsboer F, Erhardt-Lehmann A, Turck CW. Monitoring ketamine treatment response in a depressed patient via peripheral mammalian target of rapamycin activation. The American Journal of Psychiatry. 168: 751-2. PMID 21724677 DOI: 10.1176/Appi.Ajp.2011.11010128  0.318
2011 Schosser A, Gaysina D, Cohen-Woods S, Domenici E, Perry J, Tozzi F, Korszun A, Gunasinghe C, Gray J, Jones L, Binder EB, Holsboer F, Craddock N, Owen MJ, Craig IW, et al. A follow-up case-control association study of tractable (druggable) genes in recurrent major depression. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 640-50. PMID 21630437 DOI: 10.1002/Ajmg.B.31204  0.314
2011 Bonfiglio JJ, Inda C, Refojo D, Holsboer F, Arzt E, Silberstein S. The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved. Neuroendocrinology. 94: 12-20. PMID 21576930 DOI: 10.1159/000328226  0.375
2011 Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Archives of General Psychiatry. 68: 901-10. PMID 21536970 DOI: 10.1001/Archgenpsychiatry.2011.50  0.316
2011 Kohli MA, Lucae S, Saemann PG, Schmidt MV, Demirkan A, Hek K, Czamara D, Alexander M, Salyakina D, Ripke S, Hoehn D, Specht M, Menke A, Hennings J, Heck A, ... ... Holsboer F, et al. The neuronal transporter gene SLC6A15 confers risk to major depression. Neuron. 70: 252-65. PMID 21521612 DOI: 10.1016/J.Neuron.2011.04.005  0.325
2011 Fenzl T, Touma C, Romanowski CP, Ruschel J, Holsboer F, Landgraf R, Kimura M, Yassouridis A. Sleep disturbances in highly stress reactive mice: modeling endophenotypes of major depression. Bmc Neuroscience. 12: 29. PMID 21435199 DOI: 10.1186/1471-2202-12-29  0.346
2011 Paez-Pereda M, Hausch F, Holsboer F. Corticotropin releasing factor receptor antagonists for major depressive disorder. Expert Opinion On Investigational Drugs. 20: 519-35. PMID 21395482 DOI: 10.1517/13543784.2011.565330  0.372
2011 Gormanns P, Mueller NS, Ditzen C, Wolf S, Holsboer F, Turck CW. Phenome-transcriptome correlation unravels anxiety and depression related pathways. Journal of Psychiatric Research. 45: 973-9. PMID 21255794 DOI: 10.1016/J.Jpsychires.2010.12.010  0.351
2011 Dixson L, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM, Inkster B. Thyroid hormone transporter genes and grey matter changes in patients with major depressive disorder and healthy controls. Psychoneuroendocrinology. 36: 929-34. PMID 21208750 DOI: 10.1016/J.Psyneuen.2010.12.002  0.316
2011 Henkel V, Seemüller F, Obermeier M, Adli M, Bauer M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Mayr A, Riedel M, et al. Relationship between baseline severity of depression and antidepressant treatment outcome. Pharmacopsychiatry. 44: 27-32. PMID 20981642 DOI: 10.1055/S-0030-1267177  0.307
2011 Inkster B, Rao AW, Ridler K, Nichols TE, Saemann PG, Auer DP, Holsboer F, Tozzi F, Muglia P, Merlo-Pich E, Matthews PM. Structural brain changes in patients with recurrent major depressive disorder presenting with anxiety symptoms. Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. 21: 375-82. PMID 20977527 DOI: 10.1111/J.1552-6569.2010.00515.X  0.336
2011 von Wolff G, Avrabos C, Stepan J, Wurst W, Deussing JM, Holsboer F, Eder M. Voltage-sensitive dye imaging demonstrates an enhancing effect of corticotropin-releasing hormone on neuronal activity propagation through the hippocampal formation. Journal of Psychiatric Research. 45: 256-61. PMID 20619419 DOI: 10.1016/J.Jpsychires.2010.06.007  0.336
2011 Domschke K, Reif A, Weber H, Richter J, Hohoff C, Ohrmann P, Pedersen A, Bauer J, Suslow T, Kugel H, Heindel W, Baumann C, Klauke B, Jacob C, Maier W, ... ... Holsboer F, et al. Neuropeptide S receptor gene -- converging evidence for a role in panic disorder. Molecular Psychiatry. 16: 938-48. PMID 20603625 DOI: 10.1038/Mp.2010.81  0.321
2011 Dunlop BW, Betancourt Y, Binder EB, Heim C, Holsboer F, Ising M, McKenzie M, Mletzko T, Pfister H, Nemeroff CB, Craighead WE, Mayberg HS. Tolerability of the dexamethasone-corticotropin releasing hormone test in major depressive disorder. Journal of Psychiatric Research. 45: 24-8. PMID 20488460 DOI: 10.1016/J.Jpsychires.2010.04.020  0.336
2011 Lucae S, Czamara D, Uhr M, Ising M, Holsboer F, Müller-Myhsok B. The non-synonymous P2RX7 SNP rs2230912 is associated with affective disorders: Results from an association study in major depression and from a meta-analysis Pharmacopsychiatry. 44. DOI: 10.1055/S-0031-1292515  0.3
2011 Pawlowski M, Dresler M, Holsboer F, Steiger A. P.2.a.012 Cordance as a biomarker in sleep-EEG for depression: responders versus nonresponders: a naturalistic study after antidepressant medication European Neuropsychopharmacology. 21: S360-S361. DOI: 10.1016/S0924-977X(11)70576-4  0.321
2011 Hoehne N, Rief W, Brückl T, Heck A, Pfister H, Lucae S, Uhr M, Holsboer F, Ising M. Stress coping strategies and HPA axis regulation predict relapse risk in remitted depression European Neuropsychopharmacology. 21. DOI: 10.1016/S0924-977X(11)70567-3  0.329
2011 Menke A, Klengel T, Eichelkraut A, Preis L, Rex-Haffner M, Uhr M, Holsboer F, Binder E. P.1.a.021 Glucocorticoid induced FKBP5-gene expression in depressed patients and healthy controls European Neuropsychopharmacology. 21: S248-S249. DOI: 10.1016/S0924-977X(11)70384-4  0.325
2010 Schmidt MV, Trümbach D, Weber P, Wagner K, Scharf SH, Liebl C, Datson N, Namendorf C, Gerlach T, Kühne C, Uhr M, Deussing JM, Wurst W, Binder EB, Holsboer F, et al. Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16949-58. PMID 21159965 DOI: 10.1523/Jneurosci.4668-10.2010  0.356
2010 Tsolakidou A, Czibere L, Pütz B, Trümbach D, Panhuysen M, Deussing JM, Wurst W, Sillaber I, Landgraf R, Holsboer F, Rein T. Gene expression profiling in the stress control brain region hypothalamic paraventricular nucleus reveals a novel gene network including amyloid beta precursor protein. Bmc Genomics. 11: 546. PMID 20932279 DOI: 10.1186/1471-2164-11-546  0.32
2010 Luo L, Rodriguez E, Jerbi K, Lachaux JP, Martinerie J, Corbetta M, Shulman GL, Piomelli D, Turrigiano GG, Nelson SB, Joëls M, de Kloet ER, Holsboer F, Amodio DM, Frith CD, et al. Ten years of Nature Reviews Neuroscience: insights from the highly cited. Nature Reviews. Neuroscience. 11: 718-26. PMID 20852655 DOI: 10.1038/Nrn2912  0.444
2010 Heinzmann JM, Thoeringer CK, Knapman A, Palme R, Holsboer F, Uhr M, Landgraf R, Touma C. Intrahippocampal corticosterone response in mice selectively bred for extremes in stress reactivity: a microdialysis study. Journal of Neuroendocrinology. 22: 1187-97. PMID 20735798 DOI: 10.1111/J.1365-2826.2010.02062.X  0.357
2010 Deussing JM, Breu J, Kühne C, Kallnik M, Bunck M, Glasl L, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V, Fuchs H, Hölter SM, Wotjak CT, Landgraf R, ... ... Holsboer F, et al. Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9103-16. PMID 20610744 DOI: 10.1523/Jneurosci.1049-10.2010  0.326
2010 Lewis CM, Ng MY, Butler AW, Cohen-Woods S, Uher R, Pirlo K, Weale ME, Schosser A, Paredes UM, Rivera M, Craddock N, Owen MJ, Jones L, Jones I, Korszun A, ... ... Holsboer F, et al. Genome-wide association study of major recurrent depression in the U.K. population. The American Journal of Psychiatry. 167: 949-57. PMID 20516156 DOI: 10.1176/Appi.Ajp.2010.09091380  0.332
2010 Knapman A, Heinzmann JM, Holsboer F, Landgraf R, Touma C. Modeling psychotic and cognitive symptoms of affective disorders: Disrupted latent inhibition and reversal learning deficits in highly stress reactive mice. Neurobiology of Learning and Memory. 94: 145-52. PMID 20451634 DOI: 10.1016/J.Nlm.2010.04.010  0.335
2010 Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep. 33: 427-36. PMID 20394311 DOI: 10.1093/Sleep/33.4.427  0.354
2010 Unschuld PG, Ising M, Roeske D, Erhardt A, Specht M, Kloiber S, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1583-92. PMID 20237460 DOI: 10.1038/Npp.2010.30  0.382
2010 Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Pathway-based approaches to imaging genetics association studies: Wnt signaling, GSK3beta substrates and major depression. Neuroimage. 53: 908-17. PMID 20219685 DOI: 10.1016/J.Neuroimage.2010.02.065  0.319
2010 Domenici E, Willé DR, Tozzi F, Prokopenko I, Miller S, McKeown A, Brittain C, Rujescu D, Giegling I, Turck CW, Holsboer F, Bullmore ET, Middleton L, Merlo-Pich E, Alexander RC, et al. Plasma protein biomarkers for depression and schizophrenia by multi analyte profiling of case-control collections. Plos One. 5: e9166. PMID 20161799 DOI: 10.1371/Journal.Pone.0009166  0.32
2010 Kohli MA, Salyakina D, Pfennig A, Lucae S, Horstmann S, Menke A, Kloiber S, Hennings J, Bradley BB, Ressler KJ, Uhr M, Müller-Myhsok B, Holsboer F, Binder EB. Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients. Archives of General Psychiatry. 67: 348-59. PMID 20124106 DOI: 10.1001/Archgenpsychiatry.2009.201  0.337
2010 Schmidt MV, Scharf SH, Liebl C, Harbich D, Mayer B, Holsboer F, Müller MB. A novel chronic social stress paradigm in female mice. Hormones and Behavior. 57: 415-20. PMID 20100488 DOI: 10.1016/J.Yhbeh.2010.01.010  0.302
2010 Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Kronmüller K, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Dichgans E, Bottländer R, et al. Outcomes of 1014 naturalistically treated inpatients with major depressive episode. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 346-55. PMID 20097046 DOI: 10.1016/J.Euroneuro.2009.11.011  0.32
2010 Knapman A, Heinzmann JM, Hellweg R, Holsboer F, Landgraf R, Touma C. Increased stress reactivity is associated with cognitive deficits and decreased hippocampal brain-derived neurotrophic factor in a mouse model of affective disorders. Journal of Psychiatric Research. 44: 566-75. PMID 20035953 DOI: 10.1016/J.Jpsychires.2009.11.014  0.34
2010 Schmidt MV, Scharf SH, Sterlemann V, Ganea K, Liebl C, Holsboer F, Müller MB. High susceptibility to chronic social stress is associated with a depression-like phenotype. Psychoneuroendocrinology. 35: 635-43. PMID 19857931 DOI: 10.1016/J.Psyneuen.2009.10.002  0.34
2010 Holsboer F, Ising M. Stress hormone regulation: biological role and translation into therapy. Annual Review of Psychology. 61: 81-109, C1-11. PMID 19575614 DOI: 10.1146/Annurev.Psych.093008.100321  0.36
2010 Kimura M, Müller-Preuss P, Lu A, Wiesner E, Flachskamm C, Wurst W, Holsboer F, Deussing JM. Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep. Molecular Psychiatry. 15: 154-65. PMID 19455148 DOI: 10.1038/Mp.2009.46  0.349
2010 Thoeringer CK, Erhardt A, Sillaber I, Mueller MB, Ohl F, Holsboer F, Keck ME. Long-term anxiolytic and antidepressant-like behavioural effects of tiagabine, a selective GABA transporter-1 (GAT-1) inhibitor, coincide with a decrease in HPA system activity in C57BL/6 mice. Journal of Psychopharmacology (Oxford, England). 24: 733-43. PMID 19346277 DOI: 10.1177/0269881109103091  0.341
2010 Ditzen C, Varadarajulu J, Czibere L, Gonik M, Targosz BS, Hambsch B, Bettecken T, Kessler MS, Frank E, Bunck M, Teplytska L, Erhardt A, Holsboer F, Müller-Myhsok B, Landgraf R, et al. Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Molecular Psychiatry. 15: 702-11. PMID 19139748 DOI: 10.1038/Mp.2008.146  0.316
2010 Kloiber S, Kohli MA, Brueckl T, Ripke S, Ising M, Uhr M, Menke A, Unschuld PG, Horstmann S, Salyakina D, Muller-Myhsok B, Binder EB, Holsboer F, Lucae S. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular Psychiatry. 15: 736-47. PMID 19125159 DOI: 10.1038/Mp.2008.142  0.353
2010 Muglia P, Tozzi F, Galwey NW, Francks C, Upmanyu R, Kong XQ, Antoniades A, Domenici E, Perry J, Rothen S, Vandeleur CL, Mooser V, Waeber G, Vollenweider P, Preisig M, ... ... Holsboer F, et al. Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts. Molecular Psychiatry. 15: 589-601. PMID 19107115 DOI: 10.1038/Mp.2008.131  0.304
2010 Mehta D, Gonik M, Klengel T, Rex-Haffner M, Mercer-Butze K, Bradley B, Holsboer F, Ressler K, Müller-Myhsok B, Binder E. Cortisol levels and gene expression changes in posttraumatic stress disorder: the role of endophenotypes in determining common biological pathways in psychiatric disorders Experimental and Clinical Endocrinology & Diabetes. 118. DOI: 10.1055/S-0030-1267017  0.303
2010 Graf C, Vogl A, Kronsbein H, Touma C, Czeh B, Weber P, Landgraf R, Pasparakis M, Wurst W, Holsboer F, Deussing J, Refojo D. Limbic NF-KB signalling controls stress-induced anxiety and antidepressant effects independently of the HPA axis Experimental and Clinical Endocrinology & Diabetes. 118. DOI: 10.1055/S-0030-1267010  0.319
2010 Zimmermann P, Brueckl T, Nocon A, Pfister H, Lieb R, Wittchen H, Holsboer F, Angst J. P01-82 - Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity European Psychiatry. 25: 303. DOI: 10.1016/S0924-9338(10)70301-1  0.304
2009 Zimmermann P, Brückl T, Nocon A, Pfister H, Lieb R, Wittchen HU, Holsboer F, Angst J. Heterogeneity of DSM-IV major depressive disorder as a consequence of subthreshold bipolarity. Archives of General Psychiatry. 66: 1341-52. PMID 19996039 DOI: 10.1001/Archgenpsychiatry.2009.158  0.303
2009 Refojo D, Holsboer F. CRH signaling. Molecular specificity for drug targeting in the CNS. Annals of the New York Academy of Sciences. 1179: 106-19. PMID 19906235 DOI: 10.1111/J.1749-6632.2009.04983.X  0.393
2009 Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmühl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D. Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nature Neuroscience. 12: 1559-66. PMID 19898468 DOI: 10.1038/Nn.2436  0.307
2009 Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Baune BT, ... ... Holsboer F, et al. A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Archives of General Psychiatry. 66: 966-75. PMID 19736353 DOI: 10.1001/Archgenpsychiatry.2009.95  0.318
2009 Inkster B, Nichols TE, Saemann PG, Auer DP, Holsboer F, Muglia P, Matthews PM. Association of GSK3beta polymorphisms with brain structural changes in major depressive disorder. Archives of General Psychiatry. 66: 721-8. PMID 19581563 DOI: 10.1001/Archgenpsychiatry.2009.70  0.307
2009 Silberstein S, Vogl AM, Refojo D, Senin SA, Wurst W, Holsboer F, Deussing JM, Arzt E. Amygdaloid pERK1/2 in corticotropin-releasing hormone overexpressing mice under basal and acute stress conditions. Neuroscience. 159: 610-7. PMID 19361479 DOI: 10.1016/J.Neuroscience.2009.01.014  0.336
2009 Bunck M, Czibere L, Horvath C, Graf C, Frank E, Kessler MS, Murgatroyd C, Müller-Myhsok B, Gonik M, Weber P, Pütz B, Muigg P, Panhuysen M, Singewald N, Bettecken T, ... ... Holsboer F, et al. A hypomorphic vasopressin allele prevents anxiety-related behavior. Plos One. 4: e5129. PMID 19357765 DOI: 10.1371/Journal.Pone.0005129  0.335
2009 Silberstein S, Vogl AM, Bonfiglio JJ, Wurst W, Holsboer F, Arzt E, Deussing JM, Refojo D. Immunology, signal transduction, and behavior in hypothalamic-pituitary-adrenal axis-related genetic mouse models. Annals of the New York Academy of Sciences. 1153: 120-30. PMID 19236335 DOI: 10.1111/J.1749-6632.2008.03967.X  0.321
2009 Unschuld PG, Ising M, Specht M, Erhardt A, Ripke S, Heck A, Kloiber S, Straub V, Brueckl T, Müller-Myhsok B, Holsboer F, Binder EB. Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 1100-9. PMID 19229853 DOI: 10.1002/Ajmg.B.30938  0.317
2009 Schmidt MV, Sterlemann V, Wagner K, Niederleitner B, Ganea K, Liebl C, Deussing JM, Berger S, Schütz G, Holsboer F, Müller MB. Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences. Endocrinology. 150: 2709-16. PMID 19213843 DOI: 10.1210/En.2008-1211  0.369
2009 Touma C, Fenzl T, Ruschel J, Palme R, Holsboer F, Kimura M, Landgraf R. Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression. Plos One. 4: e4325. PMID 19177162 DOI: 10.1371/Journal.Pone.0004325  0.39
2009 Kalus S, Kneib T, Steiger A, Holsboer F, Yassouridis A. A new strategy to analyze possible association structures between dynamic nocturnal hormone activities and sleep alterations in humans. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1216-27. PMID 19144755 DOI: 10.1152/Ajpregu.90530.2008  0.304
2009 Künzel HE, Ackl N, Hatzinger M, Held K, Holsboer-Trachsler E, Ising M, Kaschka W, Kasper S, Konstantinidis A, Sonntag A, Uhr M, Yassouridis A, Holsboer F, Steiger A. Outcome in delusional depression comparing trimipramine monotherapy with a combination of amitriptyline and haloperidol--a double-blind multicenter trial. Journal of Psychiatric Research. 43: 702-10. PMID 19038406 DOI: 10.1016/J.Jpsychires.2008.10.004  0.332
2009 Risbrough VB, Geyer MA, Hauger RL, Coste S, Stenzel-Poore M, Wurst W, Holsboer F. CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1494-503. PMID 19020499 DOI: 10.1038/Npp.2008.205  0.343
2009 Horstmann S, Dose T, Lucae S, Kloiber S, Menke A, Hennings J, Spieler D, Uhr M, Holsboer F, Ising M. Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action. Psychoneuroendocrinology. 34: 238-48. PMID 18926641 DOI: 10.1016/J.Psyneuen.2008.09.004  0.373
2009 Binder EB, Künzel HE, Nickel T, Kern N, Pfennig A, Majer M, Uhr M, Ising M, Holsboer F. HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients. Psychoneuroendocrinology. 34: 99-109. PMID 18829172 DOI: 10.1016/J.Psyneuen.2008.08.018  0.374
2009 Thoeringer CK, Ripke S, Unschuld PG, Lucae S, Ising M, Bettecken T, Uhr M, Keck ME, Mueller-Myhsok B, Holsboer F, Binder EB, Erhardt A. The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders. Journal of Neural Transmission (Vienna, Austria : 1996). 116: 649-57. PMID 18607529 DOI: 10.1007/S00702-008-0075-Y  0.303
2009 Hennings JM, Owashi T, Binder EB, Horstmann S, Menke A, Kloiber S, Dose T, Wollweber B, Spieler D, Messer T, Lutz R, Künzel H, Bierner T, Pollmächer T, Pfister H, ... ... Holsboer F, et al. Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) project. Journal of Psychiatric Research. 43: 215-29. PMID 18586274 DOI: 10.1016/J.Jpsychires.2008.05.002  0.329
2009 Erhardt A, Müller MB, Rödel A, Welt T, Ohl F, Holsboer F, Keck ME. Consequences of chronic social stress on behaviour and vasopressin gene expression in the PVN of DBA/2OlaHsd mice--influence of treatment with the CRHR1-antagonist R121919/NBI 30775. Journal of Psychopharmacology (Oxford, England). 23: 31-9. PMID 18515457 DOI: 10.1177/0269881108089813  0.346
2009 Heck A, Lieb R, Ellgas A, Pfister H, Lucae S, Erhardt A, Himmerich H, Horstmann S, Kloiber S, Ripke S, Müller-Myhsok B, Bettecken T, Uhr M, Holsboer F, Ising M. Polymorphisms in the angiotensin-converting enzyme gene region predict coping styles in healthy adults and depressed patients. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 104-14. PMID 18484085 DOI: 10.1002/Ajmg.B.30784  0.32
2009 Zimmermann P, Brückl T, Pfister H, Lieb R, Wittchen H, Holsboer F, Ising M, Binder E, Uhr M, Nocon A. The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240261  0.341
2009 Walser S, Henniger M, Oldekamp J, Holsboer F, Wurst W, Sillaber I, Deussing J. Functional validation of P2RX7 as a susceptibility marker for depression using humanized mouse mutants Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240246  0.307
2009 Unschuld P, Ising M, Roeske D, Erhardt A, Specht M, Ripke S, Uhr M, Kloiber S, Müller-Myhsok B, Holsboer F, Binder E. Polymorphisms in the gene encoding the neuropeptide galanin are associated with HPA-axis dysregulation and symptome severity in major-depressive- and anxiety-disorder patients Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240238  0.343
2009 Touma C, Knapman A, Heinzmann J, Fenzl T, Holsboer F, Landgraf R. Mice selected for extremes in stress reactivity: modeling clinically relevant endophenotypes of major depression Pharmacopsychiatry. 42. DOI: 10.1055/S-0029-1240235  0.321
2008 Schmidt U, Holsboer F, Rein T. Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases. Proceedings of the National Academy of Sciences of the United States of America. 105: E101; author reply E. PMID 19020101 DOI: 10.1073/Pnas.0809354105  0.369
2008 Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement AB, Behl C. Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress. Neuroscience. 156: 712-21. PMID 18708129 DOI: 10.1016/J.Neuroscience.2008.07.034  0.337
2008 Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S, Horstmann S, Uhr M, Müller-Myhsok B, Holsboer F. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. The European Journal of Neuroscience. 28: 389-98. PMID 18702710 DOI: 10.1111/J.1460-9568.2008.06332.X  0.359
2008 Sillaber I, Panhuysen M, Henniger MS, Ohl F, Kühne C, Pütz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F. Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology. 200: 557-72. PMID 18629477 DOI: 10.1007/S00213-008-1232-6  0.321
2008 Holsboer F. How can we realize the promise of personalized antidepressant medicines? Nature Reviews. Neuroscience. 9: 638-46. PMID 18628772 DOI: 10.1038/Nrn2453  0.303
2008 Kronsbein HC, Jastorff AM, Maccarrone G, Stalla G, Wurst W, Holsboer F, Turck CW, Deussing JM. CRHR1-dependent effects on protein expression and posttranslational modification in AtT-20 cells. Molecular and Cellular Endocrinology. 292: 1-10. PMID 18582531 DOI: 10.1016/J.Mce.2008.05.017  0.333
2008 Tsolakidou A, Trümbach D, Panhuysen M, Pütz B, Deussing J, Wurst W, Sillaber I, Holsboer F, Rein T. Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways. Molecular and Cellular Neurosciences. 38: 444-52. PMID 18524625 DOI: 10.1016/J.Mcn.2008.04.005  0.306
2008 Friess E, Modell S, Brunner H, Tagaya H, Lauer CJ, Holsboer F, Ising M. The Munich vulnerability study on affective disorders: microstructure of sleep in high-risk subjects. European Archives of Psychiatry and Clinical Neuroscience. 258: 285-91. PMID 18504636 DOI: 10.1007/S00406-007-0795-2  0.304
2008 Himmerich H, Fulda S, Linseisen J, Seiler H, Wolfram G, Himmerich S, Gedrich K, Kloiber S, Lucae S, Ising M, Uhr M, Holsboer F, Pollmächer T. Depression, comorbidities and the TNF-alpha system. European Psychiatry : the Journal of the Association of European Psychiatrists. 23: 421-9. PMID 18504118 DOI: 10.1016/J.Eurpsy.2008.03.013  0.325
2008 Touma C, Bunck M, Glasl L, Nussbaumer M, Palme R, Stein H, Wolferstätter M, Zeh R, Zimbelmann M, Holsboer F, Landgraf R. Mice selected for high versus low stress reactivity: a new animal model for affective disorders. Psychoneuroendocrinology. 33: 839-62. PMID 18502051 DOI: 10.1016/J.Psyneuen.2008.03.013  0.391
2008 Lu A, Steiner MA, Whittle N, Vogl AM, Walser SM, Ableitner M, Refojo D, Ekker M, Rubenstein JL, Stalla GK, Singewald N, Holsboer F, Wotjak CT, Wurst W, Deussing JM. Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Molecular Psychiatry. 13: 1028-42. PMID 18475271 DOI: 10.1038/Mp.2008.51  0.347
2008 Ströhle A, Scheel M, Modell S, Holsboer F. Blunted ACTH response to dexamethasone suppression-CRH stimulation in posttraumatic stress disorder. Journal of Psychiatric Research. 42: 1185-8. PMID 18342888 DOI: 10.1016/J.Jpsychires.2008.01.015  0.34
2008 Friess E, Schmid D, Modell S, Brunner H, Lauer CJ, Holsboer F, Ising M. Dex/CRH-test response and sleep in depressed patients and healthy controls with and without vulnerability for affective disorders. Journal of Psychiatric Research. 42: 1154-62. PMID 18281062 DOI: 10.1016/J.Jpsychires.2008.01.005  0.367
2008 Holsboer F, Ising M. Central CRH system in depression and anxiety--evidence from clinical studies with CRH1 receptor antagonists. European Journal of Pharmacology. 583: 350-7. PMID 18272149 DOI: 10.1016/J.Ejphar.2007.12.032  0.399
2008 Tozzi F, Prokopenko I, Perry JD, Kennedy JL, McCarthy AD, Holsboer F, Berrettini W, Middleton LT, Chilcoat HD, Muglia P. Family history of depression is associated with younger age of onset in patients with recurrent depression. Psychological Medicine. 38: 641-9. PMID 18272011 DOI: 10.1017/S0033291707002681  0.313
2008 Schmid DA, Brunner H, Lauer CJ, Uhr M, Yassouridis A, Holsboer F, Friess E. Acute cortisol administration increases sleep depth and growth hormone release in patients with major depression. Journal of Psychiatric Research. 42: 991-9. PMID 18226817 DOI: 10.1016/J.Jpsychires.2007.12.003  0.352
2008 Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Pütz B, ... ... Holsboer F, et al. Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 57: 203-9. PMID 18215618 DOI: 10.1016/J.Neuron.2007.11.017  0.317
2008 Sterlemann V, Ganea K, Liebl C, Harbich D, Alam S, Holsboer F, Müller MB, Schmidt MV. Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders. Hormones and Behavior. 53: 386-94. PMID 18096163 DOI: 10.1016/J.Yhbeh.2007.11.001  0.316
2008 Steiner MA, Marsicano G, Nestler EJ, Holsboer F, Lutz B, Wotjak CT. Antidepressant-like behavioral effects of impaired cannabinoid receptor type 1 signaling coincide with exaggerated corticosterone secretion in mice. Psychoneuroendocrinology. 33: 54-67. PMID 17976922 DOI: 10.1016/J.Psyneuen.2007.09.008  0.359
2008 Yu S, Holsboer F, Almeida OF. Neuronal actions of glucocorticoids: focus on depression. The Journal of Steroid Biochemistry and Molecular Biology. 108: 300-9. PMID 17933520 DOI: 10.1016/J.Jsbmb.2007.09.014  0.347
2008 Steiner MA, Wanisch K, Monory K, Marsicano G, Borroni E, Bächli H, Holsboer F, Lutz B, Wotjak CT. Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice. The Pharmacogenomics Journal. 8: 196-208. PMID 17684478 DOI: 10.1038/Sj.Tpj.6500466  0.326
2008 Unschuld PG, Ising M, Erhardt A, Lucae S, Kohli M, Kloiber S, Salyakina D, Thoeringer CK, Kern N, Lieb R, Uhr M, Binder EB, Müller-Myhsok B, Holsboer F, Keck ME. Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorder. Journal of Affective Disorders. 105: 177-84. PMID 17573119 DOI: 10.1016/J.Jad.2007.05.006  0.347
2008 Zimmermann P, Kloiber S, Brueckl T, Pfister H, Wittchen HU, Holsboer F, Ising M, Lieb R. P.2.b.011 Relationship of variations in the leptin receptor (LEPR) gene and depressive symptoms is moderated by severe trauma European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70436-X  0.308
2008 Horstmann S, Lucae S, Menke A, Ising M, Müller-Myhsok B, Holsboer F, Binder E. P.1.a.021 Association of GRIK4 and HTR2A genes with antidepressant treatment in the MARS cohort of depressed inpatients European Neuropsychopharmacology. 18: S214-S215. DOI: 10.1016/S0924-977X(08)70255-4  0.315
2008 Ising M, Adena S, Binder E, Pfennig A, Schalling M, Mueller-Myhsok B, Modell S, Holsboer F. Genetic determinants of neurobiological vulnerability markers in depression European Psychiatry. 23: S9. DOI: 10.1016/J.Eurpsy.2008.01.035  0.301
2007 Ising M, Holsboer F. CRH-sub-1 receptor antagonists for the treatment of depression and anxiety. Experimental and Clinical Psychopharmacology. 15: 519-28. PMID 18179304 DOI: 10.1037/1064-1297.15.6.519  0.41
2007 Kessler MS, Murgatroyd C, Bunck M, Czibere L, Frank E, Jacob W, Horvath C, Muigg P, Holsboer F, Singewald N, Spengler D, Landgraf R. Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice. The European Journal of Neuroscience. 26: 2857-64. PMID 18001282 DOI: 10.1111/J.1460-9568.2007.05917.X  0.344
2007 Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, Ohl F, Holsboer F, Keck ME. The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice. Psychoneuroendocrinology. 32: 746-57. PMID 17583438 DOI: 10.1016/J.Psyneuen.2007.05.005  0.331
2007 Himmerich H, Zimmermann P, Ising M, Kloiber S, Lucae S, Kunzel HE, Binder EB, Holsboer F, Uhr M. Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment. Neuropsychobiology. 55: 28-35. PMID 17556850 DOI: 10.1159/000103573  0.38
2007 Schmidt MV, Sterlemann V, Ganea K, Liebl C, Alam S, Harbich D, Greetfeld M, Uhr M, Holsboer F, Müller MB. Persistent neuroendocrine and behavioral effects of a novel, etiologically relevant mouse paradigm for chronic social stress during adolescence. Psychoneuroendocrinology. 32: 417-29. PMID 17449187 DOI: 10.1016/J.Psyneuen.2007.02.011  0.318
2007 Deussing JM, Kühne C, Pütz B, Panhuysen M, Breu J, Stenzel-Poore MP, Holsboer F, Wurst W. Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1476-95. PMID 17293846 DOI: 10.1038/Sj.Jcbfm.9600451  0.31
2007 Ising M, Zimmermann US, Künzel HE, Uhr M, Foster AC, Learned-Coughlin SM, Holsboer F, Grigoriadis DE. High-affinity CRF1 receptor antagonist NBI-34041: preclinical and clinical data suggest safety and efficacy in attenuating elevated stress response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1941-9. PMID 17287823 DOI: 10.1038/Sj.Npp.1301328  0.397
2007 Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Majer M, Zihl J, Pfister H, Unschuld PG, Holsboer F, Lucae S. Overweight and obesity affect treatment response in major depression. Biological Psychiatry. 62: 321-6. PMID 17241618 DOI: 10.1016/J.Biopsych.2006.10.001  0.308
2007 Erhardt A, Lucae S, Unschuld PG, Ising M, Kern N, Salyakina D, Lieb R, Uhr M, Binder EB, Keck ME, Müller-Myhsok B, Holsboer F. Association of polymorphisms in P2RX7 and CaMKKb with anxiety disorders. Journal of Affective Disorders. 101: 159-68. PMID 17197037 DOI: 10.1016/J.Jad.2006.11.016  0.316
2007 Reppermund S, Zihl J, Lucae S, Horstmann S, Kloiber S, Holsboer F, Ising M. Persistent cognitive impairment in depression: the role of psychopathology and altered hypothalamic-pituitary-adrenocortical (HPA) system regulation. Biological Psychiatry. 62: 400-6. PMID 17188252 DOI: 10.1016/J.Biopsych.2006.09.027  0.331
2007 Ising M, Horstmann S, Kloiber S, Lucae S, Binder EB, Kern N, Künzel HE, Pfennig A, Uhr M, Holsboer F. Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biological Psychiatry. 62: 47-54. PMID 17123470 DOI: 10.1016/J.Biopsych.2006.07.039  0.367
2007 Vedder H, Schreiber W, Schuld A, Kainz M, Lauer CJ, Krieg JC, Holsboer F, Pollmächer T. Immune-endocrine host response to endotoxin in major depression. Journal of Psychiatric Research. 41: 280-9. PMID 17045296 DOI: 10.1016/J.Jpsychires.2006.07.014  0.336
2007 Thoeringer CK, Binder EB, Salyakina D, Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Brueckl TM, Mueller MB, Fuchs B, Puetz B, Lieb R, Uhr M, Holsboer F, et al. Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. Journal of Psychiatric Research. 41: 579-84. PMID 16904689 DOI: 10.1016/J.Jpsychires.2006.06.001  0.308
2007 Steiner M, Marsicano G, Nestler E, Holsboer F, Lutz B, Wotjak C. Endocannabinoid signaling modulates HPA axis activity in the mouse – implications for depression disorders Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991731  0.339
2007 Kohli M, Salyakina D, Binder E, Lucae S, Ising M, Ripke S, Horstmann S, Kloiber S, Pütz B, Lieb R, Uhr M, Müller M, Holsboer F, Müller-Myhsok B. SNPs in the NTRK2 gene are associated with depressive disorder Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991707  0.322
2007 Kohli M, Salyakina D, Binder E, Lucae S, Ising M, Ripke S, Horstmann S, Kloiber S, Pütz B, Fey K, Uhr M, Müller M, Holsboer F, Müller-Myhsok B. SNPs in the NTRK2 gene are associated with age-at-onset of depressive disorder and attempted suicide Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991706  0.308
2007 Kloiber S, Ripke S, Kohli M, Reppermund S, Salyakina D, Bettecken T, Ising M, Uhr M, Horstmann S, Dose T, Unschuld P, Zihl J, Müller-Myhsok B, Holsboer F, Lucae S. Polymorphisms in the Leptin Gene are Associated with Resistance to Antidepressant Treatment and Lower Cognitive Performance in Depression Pharmacopsychiatry. 40. DOI: 10.1055/S-2007-991701  0.301
2007 Kloiber S, Ising M, Reppermund S, Horstmann S, Dose T, Pfister H, Unschuld PG, Holsboer F, Lucae S. P.3.01 High weight affects treatment response in major depression European Neuropsychopharmacology. 17. DOI: 10.1016/S0924-977X(07)70082-2  0.311
2006 Druker J, Liberman AC, Acuña M, Giacomini D, Refojo D, Silberstein S, Pereda MP, Stalla GK, Holsboer F, Arzt E. Molecular understanding of cytokine-steroid hormone dialogue: implications for human diseases. Annals of the New York Academy of Sciences. 1088: 297-306. PMID 17192575 DOI: 10.1196/Annals.1366.007  0.311
2006 Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER. Differential disinhibition of the neonatal hypothalamic- pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. The European Journal of Neuroscience. 24: 2291-8. PMID 17042789 DOI: 10.1111/J.1460-9568.2006.05121.X  0.557
2006 Schmidt MV, Levine S, Alam S, Harbich D, Sterlemann V, Ganea K, de Kloet ER, Holsboer F, Müller MB. Metabolic signals modulate hypothalamic-pituitary-adrenal axis activation during maternal separation of the neonatal mouse. Journal of Neuroendocrinology. 18: 865-74. PMID 17026536 DOI: 10.1111/J.1365-2826.2006.01482.X  0.517
2006 Himmerich H, Binder EB, Künzel HE, Schuld A, Lucae S, Uhr M, Pollmächer T, Holsboer F, Ising M. Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axis. Biological Psychiatry. 60: 882-8. PMID 16989778 DOI: 10.1016/J.Biopsych.2006.03.075  0.309
2006 Nguyen NK, Keck ME, Hetzenauer A, Thoeringer CK, Wurst W, Deussing JM, Holsboer F, Müller MB, Singewald N. Conditional CRF receptor 1 knockout mice show altered neuronal activation pattern to mild anxiogenic challenge. Psychopharmacology. 188: 374-85. PMID 16953386 DOI: 10.1007/S00213-006-0513-1  0.32
2006 Arzt E, Holsboer F. CRF signaling: molecular specificity for drug targeting in the CNS. Trends in Pharmacological Sciences. 27: 531-8. PMID 16935354 DOI: 10.1016/J.Tips.2006.08.007  0.345
2006 Baghai TC, Binder EB, Schule C, Salyakina D, Eser D, Lucae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Illig T, Wichmann HE, Modell S, ... ... Holsboer F, et al. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Molecular Psychiatry. 11: 1003-15. PMID 16924268 DOI: 10.1038/Sj.Mp.4001884  0.337
2006 Schüssler P, Yassouridis A, Uhr M, Kluge M, Weikel J, Holsboer F, Steiger A. Growth hormone-releasing hormone and corticotropin-releasing hormone enhance non-rapid-eye-movement sleep after sleep deprivation. American Journal of Physiology. Endocrinology and Metabolism. 291: E549-56. PMID 16912060 DOI: 10.1152/Ajpendo.00641.2005  0.312
2006 Erhardt A, Ising M, Unschuld PG, Kern N, Lucae S, Pütz B, Uhr M, Binder EB, Holsboer F, Keck ME. Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2515-22. PMID 16841071 DOI: 10.1038/Sj.Npp.1301168  0.362
2006 Lucae S, Salyakina D, Barden N, Harvey M, Gagné B, Labbé M, Binder EB, Uhr M, Paez-Pereda M, Sillaber I, Ising M, Brückl T, Lieb R, Holsboer F, Müller-Myhsok B. P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Human Molecular Genetics. 15: 2438-45. PMID 16822851 DOI: 10.1093/Hmg/Ddl166  0.317
2006 Binder EB, Holsboer F. Pharmacogenomics and antidepressant drugs. Annals of Medicine. 38: 82-94. PMID 16581694 DOI: 10.1080/07853890600551045  0.319
2006 Müller MB, Holsboer F. Mice with mutations in the HPA-system as models for symptoms of depression. Biological Psychiatry. 59: 1104-15. PMID 16581037 DOI: 10.1016/J.Biopsych.2006.02.008  0.348
2006 van Rossum EF, Binder EB, Majer M, Koper JW, Ising M, Modell S, Salyakina D, Lamberts SW, Holsboer F. Polymorphisms of the glucocorticoid receptor gene and major depression. Biological Psychiatry. 59: 681-8. PMID 16580345 DOI: 10.1016/J.Biopsych.2006.02.007  0.376
2006 Welt T, Engelmann M, Renner U, Erhardt A, Müller MB, Landgraf R, Holsboer F, Keck ME. Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2573-9. PMID 16395302 DOI: 10.1038/Sj.Npp.1301006  0.333
2006 Erhardt A, Unschuld PG, Lucae S, Ising M, Salyakina D, Pütz B, Müller-Myhsok B, Binder EB, Holsboer F, Keck ME. Possible genetic implications of the endocannabinoid system in anxiety disorders versus depressive disorders European Neuropsychopharmacology. 16. DOI: 10.1016/S0924-977X(06)80104-5  0.315
2006 Binder E, Lucae S, Salyakina D, Lichtner P, Meitinger T, Bondy B, Wochnik G, Rein T, Holsboer F, Müller-Myhsok B. SNPs in FKBP5 determine a novel subtype of depression characterized by rapid response to antidepressant treatment European Neuropsychopharmacology. 16: S75. DOI: 10.1016/S0924-977X(06)80089-1  0.33
2006 Steiner M, Marsicano G, Holsboer F, Lutz B, Wotjak C. Cannabinoid receptor 1 (CB1) signaling acts as a major regulatory mechanism of hypothalamus–pituitary–adrenal (HPA) axis mediated corticosterone secretion Frontiers in Neuroendocrinology. 27: 39. DOI: 10.1016/J.Yfrne.2006.03.078  0.306
2005 Modell S, Ising M, Holsboer F, Lauer CJ. The Munich vulnerability study on affective disorders: premorbid polysomnographic profile of affected high-risk probands. Biological Psychiatry. 58: 694-9. PMID 16018976 DOI: 10.1016/J.Biopsych.2005.05.004  0.336
2005 Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmäl C, Höfels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, et al. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biological Psychiatry. 58: 307-14. PMID 16005437 DOI: 10.1016/J.Biopsych.2005.04.006  0.308
2005 Ising M, Künzel HE, Binder EB, Nickel T, Modell S, Holsboer F. The combined dexamethasone/CRH test as a potential surrogate marker in depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 1085-93. PMID 15950349 DOI: 10.1016/J.Pnpbp.2005.03.014  0.374
2005 Keck ME, Ohl F, Holsboer F, Müller MB. Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders. Neuroscience and Biobehavioral Reviews. 29: 867-89. PMID 15899517 DOI: 10.1016/J.Neubiorev.2005.03.003  0.407
2005 de Kloet ER, Joëls M, Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews. Neuroscience. 6: 463-75. PMID 15891777 DOI: 10.1038/Nrn1683  0.529
2005 Refojo D, Echenique C, Müller MB, Reul JM, Deussing JM, Wurst W, Sillaber I, Paez-Pereda M, Holsboer F, Arzt E. Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas. Proceedings of the National Academy of Sciences of the United States of America. 102: 6183-8. PMID 15833812 DOI: 10.1073/Pnas.0502070102  0.337
2005 Tichomirowa MA, Keck ME, Schneider HJ, Paez-Pereda M, Renner U, Holsboer F, Stalla GK. Endocrine disturbances in depression. Journal of Endocrinological Investigation. 28: 89-99. PMID 15816377 DOI: 10.1007/Bf03345535  0.374
2005 Keck ME, Sartori SB, Welt T, Müller MB, Ohl F, Holsboer F, Landgraf R, Singewald N. Differences in serotonergic neurotransmission between rats displaying high or low anxiety/depression-like behaviour: effects of chronic paroxetine treatment. Journal of Neurochemistry. 92: 1170-9. PMID 15715667 DOI: 10.1111/J.1471-4159.2004.02953.X  0.337
2005 Pfennig A, Kunzel HE, Kern N, Ising M, Majer M, Fuchs B, Ernst G, Holsboer F, Binder EB. Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depression. Biological Psychiatry. 57: 336-42. PMID 15705348 DOI: 10.1016/J.Biopsych.2004.11.017  0.32
2005 Post A, Ohl F, Almeida OF, Binder EB, Rücker M, Welt S, Binder E, Holsboer F, Sillaber I. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology. 180: 150-8. PMID 15682302 DOI: 10.1007/S00213-004-2134-X  0.366
2005 Winkelmann J, Prager M, Lieb R, Pfister H, Spiegel B, Wittchen HU, Holsboer F, Trenkwalder C, Ströhle A. "Anxietas tibiarum". Depression and anxiety disorders in patients with restless legs syndrome. Journal of Neurology. 252: 67-71. PMID 15654556 DOI: 10.1007/S00415-005-0604-7  0.336
2005 Schmidt MV, Schmidt M, Levine S, Oitzl MS, van der Mark M, Müller MB, Holsboer F, de Kloet ER. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Endocrinology. 146: 1458-64. PMID 15591147 DOI: 10.1210/En.2004-1042  0.542
2005 Künzel HE, Ising M, Zobel AW, Nickel T, Ackl N, Sonntag A, Holsboer F, Uhr M. Treatment with a CRH-1-receptor antagonist (R121919) does not affect weight or plasma leptin concentration in patients with major depression. Journal of Psychiatric Research. 39: 173-7. PMID 15589565 DOI: 10.1016/J.Jpsychires.2004.06.006  0.34
2005 Holsboer F. CRHR1 antagonists as novel treatment strategies. Cns Spectrums. 6: 590-4. PMID 15573022 DOI: 10.1017/S1092852900002133  0.4
2005 Ising M, Lauer CJ, Holsboer F, Modell S. The Munich vulnerability study on affective disorders: premorbid neuroendocrine profile of affected high-risk probands. Journal of Psychiatric Research. 39: 21-8. PMID 15504420 DOI: 10.1016/J.Jpsychires.2004.04.009  0.38
2005 Murgatroyd C, Wigger A, Frank E, Singewald N, Bunck M, Holsboer F, Landgraf R, Spengler D. Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7762-70. PMID 15342744 DOI: 10.1523/Jneurosci.1614-04.2004  0.307
2005 Oldekamp J, von Waldenfels J, Ulbricht S, Panhuysen M, Paez-Pereda M, Sillaber I, Holsboer F, Wurst W, Deussing J. The P2X7-Receptor – A novel candidate-gene for depression Experimental and Clinical Endocrinology & Diabetes. 113. DOI: 10.1055/S-2005-920488  0.331
2005 Unschuld P, Ising M, Erhardt A, Lucae S, Welt T, Kloiber S, Kern N, Salyakina D, Binder E, Brückl T, Uhr M, Müller-Myhsok B, Holsboer F, Keck M. Polymorphisms in the serotonin receptor gene HTR2A modulate disease severity and susceptibility for anxiety disorders but not depression and are associated with specific personality traits Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918859  0.345
2005 Thoeringer C, Sillaber I, Harbich D, Uhr M, Holsboer F, Keck M. Distinct effects of chronic antidepressant treatment on anxiety and depression-related behavior and stress hormone system regulation in an inbred mouse model for affective disorders Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918853  0.373
2005 Reppermund S, Horstmann S, Lucae S, Kloiber S, Dose T, Holsboer F, Ising M. Stress coping and personality traits in acute depression and after improvement Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918811  0.311
2005 Lu A, Steiner M, Engelholm M, Engelholm M, Wotjak C, Holsboer F, Wurst W, Deussing J. Site-specific overexpression of corticotropin-releasing hormone (CRH) in the mouse brain – modelling central CRH system hyperactivity Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918770  0.372
2005 Ising M, Binder E, Dose T, Horstmann S, Kern N, Kloiber S, Künzel H, Lucae S, Pfennig A, Unschuld P, Modell S, Holsboer F. Change in HPA system function predicts treatment response in depression Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918726  0.316
2005 Erhardt A, Seaman S, Lucae S, Kern N, Unschuld P, Welt T, Ising M, Salyakina D, Pütz B, Lieb R, Binder E, Müller-Myhsok B, Holsboer F, Keck M. Genetic implications of the endocannabinoid system in anxiety disorders versus depressive disorders: is there any evidence for the continuum hypothesis? Pharmacopsychiatry. 38. DOI: 10.1055/S-2005-918676  0.319
2005 Modell S, Holsboer F. Depression and effects of antidepressant drugs on the stress systems Techniques in the Behavioral and Neural Sciences. 15: 273-286. DOI: 10.1016/S0921-0709(05)80059-8  0.385
2005 Schmidt M, Oitzl M, Müller M, Ohl F, Wurst W, Holsboer F, Levine S, De Kloet E. Corrigendum to “Regulation of the developing hypothalamic–pituitary–adrenal axis in corticotropin releasing hormone receptor 1-deficient mice” Neuroscience. 135: 1343. DOI: 10.1016/J.Neuroscience.2005.08.015  0.304
2005 Landgraf R, Holsboer F. The involvement of neuropeptides in evolution, signaling, behavioral regulation and psychopathology: focus on vasopressin Drug Development Research. 65: 185-190. DOI: 10.1002/Ddr.20022  0.313
2004 Vila G, Papazoglou M, Stalla J, Theodoropoulou M, Stalla GK, Holsboer F, Paez-Pereda M. Sonic hedgehog regulates CRH signal transduction in the adult pituitary. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 281-3. PMID 15572433 DOI: 10.1096/Fj.04-2138Fje  0.305
2004 Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Pütz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Künzel HE, Fuchs B, Majer M, Pfennig A, ... ... Holsboer F, et al. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nature Genetics. 36: 1319-25. PMID 15565110 DOI: 10.1038/Ng1479  0.383
2004 Rüegg J, Holsboer F, Turck C, Rein T. Cofilin 1 is revealed as an inhibitor of glucocorticoid receptor by analysis of hormone-resistant cells. Molecular and Cellular Biology. 24: 9371-82. PMID 15485906 DOI: 10.1128/Mcb.24.21.9371-9382.2004  0.31
2004 Kalisch R, Salomé N, Platzer S, Wigger A, Czisch M, Sommer W, Singewald N, Heilig M, Berthele A, Holsboer F, Landgraf R, Auer DP. High trait anxiety and hyporeactivity to stress of the dorsomedial prefrontal cortex: a combined phMRI and Fos study in rats. Neuroimage. 23: 382-91. PMID 15325386 DOI: 10.1016/J.Neuroimage.2004.06.012  0.338
2004 Keck ME, Holsboer F, Müller MB. Mouse mutants for the study of corticotropin-releasing hormone receptor function: development of novel treatment strategies for mood disorders. Annals of the New York Academy of Sciences. 1018: 445-57. PMID 15240401 DOI: 10.1196/Annals.1296.055  0.377
2004 Murck H, Held K, Ziegenbein M, Künzel H, Holsboer F, Steiger A. Intravenous administration of the neuropeptide galanin has fast antidepressant efficacy and affects the sleep EEG Psychoneuroendocrinology. 29: 1205-1211. PMID 15219645 DOI: 10.1016/J.Psyneuen.2004.02.006  0.327
2004 Lauer CJ, Modell S, Schreiber W, Krieg JC, Holsboer F. Prediction of the development of a first major depressive episode with a rapid eye movement sleep induction test using the cholinergic agonist RS 86. Journal of Clinical Psychopharmacology. 24: 356-7. PMID 15118498 DOI: 10.1097/01.Jcp.0000125744.22031.3A  0.315
2004 Holsboer F. High-quality antidepressant discovery by understanding stress hormone physiology. Annals of the New York Academy of Sciences. 1007: 394-404. PMID 14993072 DOI: 10.1196/Annals.1286.038  0.348
2004 Held K, Künzel H, Ising M, Schmid DA, Zobel A, Murck H, Holsboer F, Steiger A. Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression. Journal of Psychiatric Research. 38: 129-36. PMID 14757326 DOI: 10.1016/S0022-3956(03)00076-1  0.334
2004 Müller MB, Uhr M, Holsboer F, Keck ME. Hypothalamic-pituitary-adrenocortical system and mood disorders: highlights from mutant mice. Neuroendocrinology. 79: 1-12. PMID 14755129 DOI: 10.1159/000076041  0.369
2004 Ströhle A, Holsboer F. Stress responsive neurohormones in depression and anxiety. Pharmacopsychiatry. S207-14. PMID 14677081 DOI: 10.1055/S-2003-45132  0.395
2004 Friess E, Tagaya H, Grethe C, Trachsel L, Holsboer F. Acute cortisol administration promotes sleep intensity in man. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 598-604. PMID 14647485 DOI: 10.1038/Sj.Npp.1300362  0.3
2004 Wigger A, Sánchez MM, Mathys KC, Ebner K, Frank E, Liu D, Kresse A, Neumann ID, Holsboer F, Plotsky PM, Landgraf R. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1-14. PMID 12942143 DOI: 10.1038/Sj.Npp.1300290  0.389
2004 Rupprecht R, Lancel M, Friess E, Ströhle A, Holsboer F, Romeo E. GABAergic effects of neuroactive steroids: Modulation of sleep and anxiety Pharmacopsychiatry. 36. DOI: 10.1055/S-2003-825483  0.301
2004 Pfennig A, Kuenzel H, Kern N, Fuchs B, Brunner J, Ising M, Modell S, Müller-Myhsok B, Binder E, Holsboer F. HPA axis dysregulation and suicidal behavior in depression – Differentiation of a genetically distinct subgroup? Pharmacopsychiatry. 36. DOI: 10.1055/S-2003-825457  0.304
2004 Kern N, Binder E, Künzel H, Pfennig A, Fuchs B, Ising M, Erhardt A, Lucae S, Müller-Myhsok B, Modell S, Keck M, Holsboer F. Is there a genetic continuum between anxiety and depression? Pharmacopsychiatry. 36. DOI: 10.1055/S-2003-825399  0.313
2004 Müller M, Zimmermann S, Sillaber I, Hagemeyer T, Deussing J, Droste S, Reul J, Holsboer F, Wurst W. Limbic Crhr1 mediates anxiety-related behaviour and is required for hormonal adaptation to stress Pharmacopsychiatry. 36. DOI: 10.1016/S0924-977X(04)90032-6  0.316
2004 Holsboer F. Therapeutics for depression and anxiety disorders Drug Discovery Today: Therapeutic Strategies. 1: 105-109. DOI: 10.1016/J.Ddstr.2004.08.012  0.402
2003 Künzel HE, Zobel AW, Nickel T, Ackl N, Uhr M, Sonntag A, Ising M, Holsboer F. Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects. Journal of Psychiatric Research. 37: 525-33. PMID 14563384 DOI: 10.1016/S0022-3956(03)00070-0  0.375
2003 Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. Journal of Psychiatric Research. 37: 463-70. PMID 14563377 DOI: 10.1016/S0022-3956(03)00054-2  0.358
2003 Müller MB, Zimmermann S, Sillaber I, Hagemeyer TP, Deussing JM, Timpl P, Kormann MS, Droste SK, Kühn R, Reul JM, Holsboer F, Wurst W. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nature Neuroscience. 6: 1100-7. PMID 12973355 DOI: 10.1038/Nn1123  0.378
2003 Künzel HE, Binder EB, Nickel T, Ising M, Fuchs B, Majer M, Pfennig A, Ernst G, Kern N, Schmid DA, Uhr M, Holsboer F, Modell S. Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2169-78. PMID 12931142 DOI: 10.1038/Sj.Npp.1300280  0.366
2003 Oshima A, Flachskamm C, Reul JM, Holsboer F, Linthorst AC. Altered serotonergic neurotransmission but normal hypothalamic-pituitary-adrenocortical axis activity in mice chronically treated with the corticotropin-releasing hormone receptor type 1 antagonist NBI 30775. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 2148-59. PMID 12915860 DOI: 10.1038/Sj.Npp.1300267  0.354
2003 Müller MB, Keck ME, Binder EB, Kresse AE, Hagemeyer TP, Landgraf R, Holsboer F, Uhr M. ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1991-9. PMID 12888779 DOI: 10.1038/Sj.Npp.1300257  0.353
2003 Herr AS, Tsolakidou AF, Yassouridis A, Holsboer F, Rein T. Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro. Neuroendocrinology. 78: 12-22. PMID 12869795 DOI: 10.1159/000071701  0.359
2003 Rosenhagen MC, Sōti C, Schmidt U, Wochnik GM, Hartl FU, Holsboer F, Young JC, Rein T. The heat shock protein 90-targeting drug cisplatin selectively inhibits steroid receptor activation. Molecular Endocrinology (Baltimore, Md.). 17: 1991-2001. PMID 12869591 DOI: 10.1210/Me.2003-0141  0.306
2003 van Gaalen MM, Stenzel-Poore M, Holsboer F, Steckler T. Reduced attention in mice overproducing corticotropin-releasing hormone. Behavioural Brain Research. 142: 69-79. PMID 12798267 DOI: 10.1016/S0166-4328(02)00381-9  0.357
2003 Refojo D, Liberman AC, Giacomini D, Carbia Nagashima A, Graciarena M, Echenique C, Paez Pereda M, Stalla G, Holsboer F, Arzt E. Integrating systemic information at the molecular level: cross-talk between steroid receptors and cytokine signaling on different target cells. Annals of the New York Academy of Sciences. 992: 196-204. PMID 12794059 DOI: 10.1111/J.1749-6632.2003.Tb03150.X  0.303
2003 Schmidt MV, Schmidt M, Oitzl MS, Müller MB, Ohl F, Wurst W, Holsboer F, Levine S, De Kloet ER. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Neuroscience. 119: 589-95. PMID 12770571 DOI: 10.1016/S0306-4522(03)00097-6  0.559
2003 Bachmann CG, Linthorst AC, Holsboer F, Reul JM. Effect of chronic administration of selective glucocorticoid receptor antagonists on the rat hypothalamic-pituitary-adrenocortical axis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1056-67. PMID 12700716 DOI: 10.1038/Sj.Npp.1300158  0.333
2003 Keck ME, Welt T, Müller MB, Landgraf R, Holsboer F. The high-affinity non-peptide CRH1 receptor antagonist R121919 attenuates stress-induced alterations in plasma oxytocin, prolactin, and testosterone secretion in rats. Pharmacopsychiatry. 36: 27-31. PMID 12649771 DOI: 10.1055/S-2003-38092  0.358
2003 Nickel T, Sonntag A, Schill J, Zobel AW, Ackl N, Brunnauer A, Murck H, Ising M, Yassouridis A, Steiger A, Zihl J, Holsboer F. Clinical and neurobiological effects of tianeptine and paroxetine in major depression. Journal of Clinical Psychopharmacology. 23: 155-68. PMID 12640217 DOI: 10.1097/00004714-200304000-00008  0.343
2003 Murck H, Nickel T, Künzel H, Antonijevic IA, Schill J, Zobel A, Steiger A, Sonntag A, Holsboer F. State markers of depression in sleep EEG: dependency on drug and gender in patients treated with tianeptine or paroxetine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 348-58. PMID 12589388 DOI: 10.1038/Sj.Npp.1300029  0.329
2003 Keck ME, Welt T, Müller MB, Uhr M, Ohl F, Wigger A, Toschi N, Holsboer F, Landgraf R. Reduction of hypothalamic vasopressinergic hyperdrive contributes to clinically relevant behavioral and neuroendocrine effects of chronic paroxetine treatment in a psychopathological rat model. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 235-43. PMID 12589376 DOI: 10.1038/Sj.Npp.1300040  0.328
2003 Holsboer F. Antidepressant drug discovery in the postgenomic era. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 2: 165-77. PMID 12587145 DOI: 10.3109/15622970109026805  0.301
2003 Paez-Pereda M, Giacomini D, Refojo D, Nagashima AC, Hopfner U, Grubler Y, Chervin A, Goldberg V, Goya R, Hentges ST, Low MJ, Holsboer F, Stalla GK, Arzt E. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Proceedings of the National Academy of Sciences of the United States of America. 100: 1034-9. PMID 12552124 DOI: 10.1073/Pnas.0237312100  0.301
2002 van Gaalen MM, Reul JH, Gesing A, Stenzel-Poore MP, Holsboer F, Steckler T. Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge. Genes, Brain, and Behavior. 1: 174-7. PMID 12884973 DOI: 10.1034/J.1601-183X.2002.10305.X  0.374
2002 Linthorst AC, Peñalva RG, Flachskamm C, Holsboer F, Reul JM. Forced swim stress activates rat hippocampal serotonergic neurotransmission involving a corticotropin-releasing hormone receptor-dependent mechanism. The European Journal of Neuroscience. 16: 2441-52. PMID 12492439 DOI: 10.1046/J.1460-9568.2002.02400.X  0.388
2002 Müller MB, Holsboer F, Keck ME. Genetic modification of corticosteroid receptor signalling: Novel insights into pathophysiology and treatment strategies of human affective disorders Neuropeptides. 36: 117-131. PMID 12359503 DOI: 10.1054/Npep.2002.0896  0.395
2002 Modell S, Ising M, Holsboer F, Lauer CJ. The Munich Vulnerability Study on Affective Disorders: stability of polysomnographic findings over time. Biological Psychiatry. 52: 430-7. PMID 12242059 DOI: 10.1016/S0006-3223(02)01398-7  0.347
2002 Keck ME, Welt T, Müller MB, Erhardt A, Ohl F, Toschi N, Holsboer F, Sillaber I. Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropharmacology. 43: 101-9. PMID 12213264 DOI: 10.1016/S0028-3908(02)00069-2  0.301
2002 Lancel M, Müller-Preuss P, Wigger A, Landgraf R, Holsboer F. The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety. Journal of Psychiatric Research. 36: 197-208. PMID 12191624 DOI: 10.1016/S0022-3956(02)00009-2  0.356
2002 van Gaalen MM, Stenzel-Poore MP, Holsboer F, Steckler T. Effects of transgenic overproduction of CRH on anxiety-like behaviour. The European Journal of Neuroscience. 15: 2007-15. PMID 12099906 DOI: 10.1046/J.1460-9568.2002.02040.X  0.322
2002 Otte C, Kellner M, Arlt J, Jahn H, Holsboer F, Wiedemann K. Prolactin but not ACTH increases during sodium lactate-induced panic attacks Psychiatry Research-Neuroimaging. 109: 201-205. PMID 11927145 DOI: 10.1016/S0165-1781(02)00014-8  0.344
2002 Landgrebe J, Welzl G, Metz T, van Gaalen MM, Ropers H, Wurst W, Holsboer F. Molecular characterisation of antidepressant effects in the mouse brain using gene expression profiling. Journal of Psychiatric Research. 36: 119-29. PMID 11886689 DOI: 10.1016/S0022-3956(01)00061-9  0.318
2002 Peñalva RG, Flachskamm C, Zimmermann S, Wurst W, Holsboer F, Reul JM, Linthorst AC. Corticotropin-releasing hormone receptor type 1-deficiency enhances hippocampal serotonergic neurotransmission: an in vivo microdialysis study in mutant mice. Neuroscience. 109: 253-66. PMID 11801362 DOI: 10.1016/S0306-4522(01)00475-4  0.35
2002 Reul JM, Holsboer F. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Current Opinion in Pharmacology. 2: 23-33. PMID 11786305 DOI: 10.1016/S1471-4892(01)00117-5  0.364
2002 Keck ME, Wigger A, Welt T, Müller MB, Gesing A, Reul JM, Holsboer F, Landgraf R, Neumann ID. Vasopressin mediates the response of the combined dexamethasone/CRH test in hyper-anxious rats: implications for pathogenesis of affective disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 94-105. PMID 11751036 DOI: 10.1016/S0893-133X(01)00351-7  0.331
2002 Rupprecht R, di Michele F, Hermann B, Ströhle A, Lancel M, Romeo E, Holsboer F. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Research. Brain Research Reviews. 37: 59-67. PMID 11744074 DOI: 10.1016/S0165-0173(01)00123-0  0.367
2002 Rupprecht R, Holsboer F. Neuroactive steroids in neuropsychopharmacology. International Review of Neurobiology. 46: 461-77. PMID 11599310 DOI: 10.1016/S0074-7742(01)46072-7  0.368
2001 Müller MB, Lucassen PJ, Yassouridis A, Hoogendijk WJ, Holsboer F, Swaab DF. Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus. The European Journal of Neuroscience. 14: 1603-12. PMID 11860455 DOI: 10.1046/J.0953-816X.2001.01784.X  0.345
2001 Preil J, Müller MB, Gesing A, Reul JM, Sillaber I, van Gaalen MM, Landgrebe J, Holsboer F, Stenzel-Poore M, Wurst W. Regulation of the hypothalamic-pituitary-adrenocortical system in mice deficient for CRH receptors 1 and 2. Endocrinology. 142: 4946-55. PMID 11606463 DOI: 10.1210/Endo.142.11.8507  0.349
2001 Müller MB, Preil J, Renner U, Zimmermann S, Kresse AE, Stalla GK, Keck ME, Holsboer F, Wurst W. Expression of CRHR1 and CRHR2 in mouse pituitary and adrenal gland: implications for HPA system regulation. Endocrinology. 142: 4150-3. PMID 11517194 DOI: 10.1210/Endo.142.9.8491  0.372
2001 Holsboer F. Prospects for antidepressant drug discovery. Biological Psychology. 57: 47-65. PMID 11454434 DOI: 10.1016/S0301-0511(01)00089-8  0.329
2001 Zobel AW, Nickel T, Sonntag A, Uhr M, Holsboer F, Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study. Journal of Psychiatric Research. 35: 83-94. PMID 11377437 DOI: 10.1016/S0022-3956(01)00013-9  0.353
2001 Keck ME, Holsboer F. Hyperactivity of CRH neuronal circuits as a target for therapeutic interventions in affective disorders Peptides. 22: 835-844. PMID 11337098 DOI: 10.1016/S0196-9781(01)00398-9  0.392
2001 Steckler T, Rammes G, Sauvage M, Van Gaalen MM, Weis C, Zieglgänsberger W, Holsboer F. Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice Journal of Psychiatric Research. 35: 29-42. PMID 11287054 DOI: 10.1016/S0022-3956(00)00040-6  0.321
2001 Steckler T, Holsboer F. Conditioned activity to amphetamine in transgenic mice expressing an antisense RNA against the glucocorticoid receptor. Behavioral Neuroscience. 115: 207-19. PMID 11256444 DOI: 10.1037/0735-7044.115.1.207  0.319
2001 Holsboer F. Stress, hypercortisolism and corticosteroid receptors in depression: implications for therapy. Journal of Affective Disorders. 62: 77-91. PMID 11172875 DOI: 10.1016/S0165-0327(00)00352-9  0.387
2001 Krieg JC, Lauer CJ, Schreiber W, Modell S, Holsboer F. Neuroendocrine, polysomnographic and psychometric observations in healthy subjects at high familial risk for affective disorders: the current state of the 'Munich vulnerability study'. Journal of Affective Disorders. 62: 33-7. PMID 11172871 DOI: 10.1016/S0165-0327(00)00348-7  0.367
2001 Keck ME, Welt T, Wigger A, Renner U, Engelmann M, Holsboer F, Landgraf R. The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats. The European Journal of Neuroscience. 13: 373-80. PMID 11168542 DOI: 10.1046/J.0953-816X.2000.01383.X  0.337
2001 Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American Journal of Pathology. 158: 453-68. PMID 11159183 DOI: 10.1016/S0002-9440(10)63988-0  0.532
2001 Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients Psychoneuroendocrinology. 26: 65-76. PMID 11070335 DOI: 10.1016/S0306-4530(00)00039-1  0.372
2001 Gesing A, Bilang-Bleuel A, Droste SK, Linthorst ACE, Holsboer F, Reul JMHM. Psychological Stress Increases Hippocampal Mineralocorticoid Receptor Levels: Involvement of Corticotropin-Releasing Hormone The Journal of Neuroscience. 21: 4822-4829. DOI: 10.1523/Jneurosci.21-13-04822.2001  0.34
2001 Hundt W, Zimmermann U, Pottig M, Spring K, Holsboer F. The Combined Dexamethasone-Suppression/CRH-Stimulation Test in Alcoholics During and After Acute Withdrawal Alcoholism: Clinical and Experimental Research. 25: 687-691. DOI: 10.1111/J.1530-0277.2001.Tb02268.X  0.315
2001 Steckler T, Van Gaalen M, Sauvage M, Reul J, Stenzel-Poore M, Holsboer F. Genetically modified animals to analyse the abnormalities in the hypothalamic-pituitary-adrenal axis in depression European Neuropsychopharmacology. 11: S167-S168. DOI: 10.1016/S0924-977X(01)80102-4  0.343
2000 Hermann B, Landgraf R, Keck ME, Wigger A, Morrow AL, Ströhle A, Holsboer F, Rupprecht R. Pharmacological characterisation of cortical gamma-aminobutyric acid type A (GABAA) receptors in two Wistar rat lines selectively bred for high and low anxiety-related behaviour. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 1: 137-43. PMID 12607222 DOI: 10.3109/15622970009150581  0.304
2000 Reul JM, Bilang-Bleuel A, Droste S, Linthorst AC, Holsboer F, Gesing A. New mode of hypothalamic-pituitary-adrenocortical axis regulation: significance for stress-related disorders. Zeitschrift Fã¼R Rheumatologie. 59: II/22-5. PMID 11155799 DOI: 10.1007/S003930070013  0.358
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Keck ME, Zimmermann S, Holsboer F, Wurst W. Selective activation of the hypothalamic vasopressinergic system in mice deficient for the corticotropin-releasing hormone receptor 1 is dependent on glucocorticoids. Endocrinology. 141: 4262-9. PMID 11089561 DOI: 10.1210/Endo.141.11.7767  0.341
2000 Schuld A, Blum WF, Uhr M, Haack M, Kraus T, Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy. Neuroendocrinology. 72: 195-8. PMID 11070422 DOI: 10.1159/000054587  0.315
2000 Reul JM, Gesing A, Droste S, Stec IS, Weber A, Bachmann C, Bilang-Bleuel A, Holsboer F, Linthorst AC. The brain mineralocorticoid receptor: greedy for ligand, mysterious in function. European Journal of Pharmacology. 405: 235-49. PMID 11033331 DOI: 10.1016/S0014-2999(00)00677-4  0.338
2000 Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 477-501. PMID 11027914 DOI: 10.1016/S0893-133X(00)00159-7  0.379
2000 Schiffelholz T, Holsboer F, Lancel M. High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats. Physiology & Behavior. 69: 399-404. PMID 10913777 DOI: 10.1016/S0031-9384(00)00218-3  0.305
2000 Zobel AW, Nickel T, Künzel HE, Ackl N, Sonntag A, Ising M, Holsboer F. Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. Journal of Psychiatric Research. 34: 171-81. PMID 10867111 DOI: 10.1016/S0022-3956(00)00016-9  0.4
2000 Heuser I, Deuschle M, Weber B, Stalla GK, Holsboer F. Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralocorticoid receptor antagonist spironolactone. Psychoneuroendocrinology. 25: 513-8. PMID 10818284 DOI: 10.1016/S0306-4530(00)00006-8  0.38
2000 Antonijevic IA, Murck H, Bohlhalter S, Frieboes R, Holsboer F, Steiger A. Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology. 39: 1474-1481. PMID 10818263 DOI: 10.1016/S0028-3908(00)00057-5  0.336
2000 Keck ME, Hatzinger M, Wotjak CT, Landgraf R, Holsboer F, Neumann ID. Ageing alters intrahypothalamic release patterns of vasopressin and oxytocin in rats. The European Journal of Neuroscience. 12: 1487-94. PMID 10762376 DOI: 10.1046/J.1460-9568.2000.00030.X  0.302
2000 Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmächer T. Dose-dependent effects of endotoxin on human sleep. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 278: R947-55. PMID 10749783 DOI: 10.1152/Ajpregu.2000.278.4.R947  0.315
2000 Herr AS, Wochnik GM, Rosenhagen MC, Holsboer F, Rein T. Rifampicin is not an activator of glucocorticoid receptor. Molecular Pharmacology. 57: 732-7. PMID 10727519 DOI: 10.1124/Mol.57.4.732  0.332
2000 Neumann ID, Wigger A, Torner L, Holsboer F, Landgraf R. Brain oxytocin inhibits basal and stress-induced activity of the hypothalamo-pituitary-adrenal axis in male and female rats: partial action within the paraventricular nucleus. Journal of Neuroendocrinology. 12: 235-43. PMID 10718919 DOI: 10.1046/J.1365-2826.2000.00442.X  0.332
2000 Ströhle A, Holsboer F, Rupprecht R. Increased ACTH concentrations associated with cholecystokinin tetrapeptide-induced panic attacks in patients with panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 251-6. PMID 10693152 DOI: 10.1016/S0893-133X(99)00115-3  0.345
2000 Hatzinger M, Wotjak CT, Naruo T, Simchen R, Keck ME, Landgraf R, Holsboer F, Neumann ID. Endogenous vasopressin contributes to hypothalamic-pituitary-adrenocortical alterations in aged rats. The Journal of Endocrinology. 164: 197-205. PMID 10657855 DOI: 10.1677/Joe.0.1640197  0.336
2000 Linthorst AC, Flachskamm C, Barden N, Holsboer F, Reul JM. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice. The European Journal of Neuroscience. 12: 283-91. PMID 10651883 DOI: 10.1046/J.1460-9568.2000.00878.X  0.315
2000 Steckler T, Holsboer F. Corticotropin-releasing hormone receptor subtypes and emotion. Biological Psychiatry. 46: 1480-508. PMID 10599478 DOI: 10.1016/S0006-3223(99)00170-5  0.357
2000 Antonijevic IA, Murck H, Frieboes R, Holsboer F, Steiger A. On the gender differences in sleep-endocrine regulation in young normal humans. Neuroendocrinology. 70: 280-7. PMID 10529623 DOI: 10.1159/000054487  0.303
2000 Preil J, Müller MB, Keck ME, Zimmermann S, Holsboer F, Wurst W. Disruption of feeding behaviour in corticotropin releasing hormone type-1 receptor (CRHR1) deficient mice is dependent on glucocorticoids European Neuropsychopharmacology. 10: 405. DOI: 10.1016/S0924-977X(00)80578-7  0.309
2000 Müller MB, Landgraf R, Preil J, Sillaber I, Kresse AE, Stalla GK, Keck ME, Zimmermann S, Holsboer F, Wurst W. Neuroendocrine regulation in mice deficient for the corticotropin-releasing hormone receptor 1 (CRHR1): activation of the vasopressinergic system and involvement of CRHR1 in adrenocortical function European Neuropsychopharmacology. 10: 404-405. DOI: 10.1016/S0924-977X(00)80577-5  0.322
2000 Zobel A, Frieboes R, Ising M, Holsboer F. Cortisol response to the Dex/CRH test predicts medium-term-outcome in patients with remitted depression European Neuropsychopharmacology. 10: 275-276. DOI: 10.1016/S0924-977X(00)80271-0  0.31
2000 Zobel A, Nickel T, Künzel H, Ackl N, Sonntag A, Ising M, Holsboer F. CRH, HPA system hyperactivity and depression European Neuropsychopharmacology. 10: 275. DOI: 10.1016/S0924-977X(00)80270-9  0.328
2000 Schmid D, Brunner H, Holsboer F, Friess E. Cortisol promotes non-REM sleep in patients with major depression European Neuropsychopharmacology. 10: 256. DOI: 10.1016/S0924-977X(00)80224-2  0.338
2000 Schmid D, Brunner H, Holsboer F, Frieß E. 289. Effects of cortisol on sleep EEG and growth hormone secretion in major depression depending on HPA-function? Biological Psychiatry. 47: S87-S88. DOI: 10.1016/S0006-3223(00)00553-9  0.361
2000 Antonijevic I, Murck H, Frieboes R, Holsboer F, Steiger A. 264. Sleep-endocrine effects of GHRH in depression are sexually dimorphic Biological Psychiatry. 47: S80. DOI: 10.1016/S0006-3223(00)00528-X  0.311
2000 Holsboer F. 209. CRF-receptors as drug targets for treatment of anxiety and depression Biological Psychiatry. 47: S64. DOI: 10.1016/S0006-3223(00)00472-8  0.352
1999 Steckler T, Holsboer F, Reul JM. Glucocorticoids and depression. Bailliã¨Re's Best Practice & Research. Clinical Endocrinology & Metabolism. 13: 597-614. PMID 10903817 DOI: 10.1053/Beem.1999.0046  0.395
1999 Engelmann M, Ebner K, Landgraf R, Holsboer F, Wotjak CT. Emotional stress triggers intrahypothalamic but not peripheral release of oxytocin in male rats Journal of Neuroendocrinology. 11: 867-872. PMID 10520137 DOI: 10.1046/J.1365-2826.1999.00403.X  0.318
1999 Bergh FT, Kümpfel T, Trenkwalder C, Rupprecht R, Holsboer F. Dysregulation of the hypothalamo-pituitary-adrenal axis is related to the clinical course of MS Neurology. 53: 772-777. PMID 10489039 DOI: 10.1212/Wnl.53.4.772  0.307
1999 Rupprecht R, Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends in Neurosciences. 22: 410-6. PMID 10441302 DOI: 10.1016/S0166-2236(99)01399-5  0.371
1999 Frieboes R, Müller U, Murck H, Cramon DYv, Holsboer F, Steiger A. Nocturnal hormone secretion and the sleep EEG in patients several months after traumatic brain injury. Journal of Neuropsychiatry and Clinical Neurosciences. 11: 354-360. PMID 10440012 DOI: 10.1176/Jnp.11.3.354  0.335
1999 Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. Journal of Psychiatric Research. 33: 181-214. PMID 10367986 DOI: 10.1016/S0022-3956(98)90056-5  0.403
1999 Zobel AW, Yassouridis A, Frieboes RM, Holsboer F. Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. The American Journal of Psychiatry. 156: 949-51. PMID 10360139 DOI: 10.1176/Ajp.156.6.949  0.365
1999 Landgraf R, Wigger A, Holsboer F, Neumann ID. Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour. Journal of Neuroendocrinology. 11: 405-7. PMID 10336720 DOI: 10.1046/J.1365-2826.1999.00342.X  0.339
1999 Liebsch G, Landgraf R, Engelmann M, Lörscher P, Holsboer F. Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. Journal of Psychiatric Research. 33: 153-63. PMID 10221747 DOI: 10.1016/S0022-3956(98)80047-2  0.341
1999 Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmächer T. Effects of granulocyte colony-stimulating factor on night sleep in humans. The American Journal of Physiology. 276: R1149-55. PMID 10198397 DOI: 10.1152/Ajpregu.1999.276.4.R1149  0.313
1999 Ebner K, Wotjak CT, Holsboer F, Landgraf R, Engelmann M. Vasopressin released within the septal brain area during swim stress modulates the behavioural stress response in rats. The European Journal of Neuroscience. 11: 997-1002. PMID 10103093 DOI: 10.1046/J.1460-9568.1999.00508.X  0.337
1999 Ströhle A, Kellner M, Holsboer F, Wiedemann K. Behavioral, neuroendocrine, and cardiovascular response to flumazenil: no evidence for an altered benzodiazepine receptor sensitivity in panic disorder. Biological Psychiatry. 45: 321-6. PMID 10023509 DOI: 10.1016/S0006-3223(98)00295-9  0.311
1999 Lancel M, Faulhaber J, Holsboer F, Rupprecht R. The GABA(A) receptor antagonist picrotoxin attenuates most sleep changes induced by progesterone. Psychopharmacology. 141: 213-9. PMID 9952047 DOI: 10.1007/S002130050827  0.313
1999 Lauer CJ, Schreiber W, Modell S, Holsboer F, Krieg JC. The Munich vulnerability study on affective disorders: overview of the cross-sectional observations at index investigation. Journal of Psychiatric Research. 32: 393-401. PMID 9844956 DOI: 10.1016/S0022-3956(98)00026-0  0.357
1999 Antonijevic I, Murck H, Frieboes R, Steiger A, Holsboer F. Altered sleep-endocrine regulation in depression — effect of GHRH European Neuropsychopharmacology. 9: 251. DOI: 10.1016/S0924-977X(99)80237-5  0.349
1998 Rupprecht R, Ströhle A, Hermann B, Michele Fd, Spalletta G, Pasini A, Holsboer F, Romeo E. Neuroactive steroid concentrations following metyrapone administration in depressed patients and healthy volunteers Biological Psychiatry. 44: 912-914. PMID 9807647 DOI: 10.1016/S0006-3223(97)00521-0  0.353
1998 Neumann ID, Wigger A, Liebsch G, Holsboer F, Landgraf R. Increased basal activity of the hypothalamo-pituitary-adrenal axis during pregnancy in rats bred for high anxiety-related behaviour. Psychoneuroendocrinology. 23: 449-63. PMID 9802120 DOI: 10.1016/S0306-4530(98)00023-7  0.301
1998 Heuser I, Bissette G, Dettling M, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Nemeroff CB, Holsboer F. Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: response to amitriptyline treatment. Depression and Anxiety. 8: 71-9. PMID 9784981 DOI: 10.1002/(Sici)1520-6394(1998)8:2<71::Aid-Da5>3.0.Co;2-N  0.351
1998 Liebsch G, Linthorst AC, Neumann ID, Reul JM, Holsboer F, Landgraf R. Behavioral, physiological, and neuroendocrine stress responses and differential sensitivity to diazepam in two Wistar rat lines selectively bred for high- and low-anxiety-related behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 381-96. PMID 9778660 DOI: 10.1016/S0893-133X(98)00042-6  0.322
1998 Wiedemann K, Hirschmann M, Knaudt K, Rupprecht R, Seier FE, Holsboer F. Sleep endocrine effects of megestrol acetate in healthy men Journal of Neuroendocrinology. 10: 719-727. PMID 9744490 DOI: 10.1046/J.1365-2826.1998.00259.X  0.334
1998 Lauer CJ, Schreiber W, Modell S, Holsboer F, Krieg JC. [The Munich Vulnerability Study of Affective Disorders. Overview of the results at index study]. Der Nervenarzt. 69: 574-85. PMID 9715475 DOI: 10.1007/S001150050314  0.374
1998 Hemmeter U, Rothe B, Guldner J, Holsboer F, Steiger A. Effects of thyrotropin-releasing hormone on the sleep EEG and nocturnal hormone secretion in male volunteers. Neuropsychobiology. 38: 25-31. PMID 9701719 DOI: 10.1159/000026513  0.341
1998 Kellner M, Knaudt K, Jahn H, Holsboer F, Wiedemann K. Atrial natriuretic hormone in lactate-induced panic attacks: mode of release and endocrine and pathophysiological consequences. Journal of Psychiatric Research. 32: 37-48. PMID 9693999 DOI: 10.1016/S0022-3956(97)00034-4  0.35
1998 Wotjak CT, Ganster J, Kohl G, Holsboer F, Landgraf R, Engelmann M. Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: New insights into the secretory capacities of peptidergic neurons Neuroscience. 85: 1209-1222. PMID 9681958 DOI: 10.1016/S0306-4522(97)00683-0  0.315
1998 Ströhle A, Poettig M, Barden N, Holsboer F, Montkowski A. Age- and stimulus-dependent changes in anxiety-related behaviour of transgenic mice with GR dysfunction. Neuroreport. 9: 2099-102. PMID 9674601 DOI: 10.1097/00001756-199806220-00035  0.312
1998 Romeo E, Ströhle A, Spalletta G, di Michele F, Hermann B, Holsboer F, Pasini A, Rupprecht R. Effects of antidepressant treatment on neuroactive steroids in major depression. The American Journal of Psychiatry. 155: 910-3. PMID 9659856 DOI: 10.1176/Ajp.155.7.910  0.345
1998 Skutella T, Probst JC, Renner U, Holsboer F, Behl C. Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety. Neuroscience. 85: 795-805. PMID 9639273 DOI: 10.1016/S0306-4522(97)00682-9  0.329
1998 Sillaber I, Montkowski A, Landgraf R, Barden N, Holsboer F, Spanagel R. Enhanced morphine-induced behavioural effects and dopamine release in the nucleus accumbens in a transgenic mouse model of impaired glucocorticoid (type II) receptor function: influence of long-term treatment with the antidepressant moclobemide. Neuroscience. 85: 415-25. PMID 9622241 DOI: 10.1016/S0306-4522(97)00607-6  0.314
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.372
1998 Ströhle A, Kellner M, Holsboer F, Wiedemann K. Atrial natriuretic hormone decreases endocrine response to a combined dexamethasone-corticotropin-releasing hormone test. Biological Psychiatry. 43: 371-5. PMID 9513753 DOI: 10.1016/S0006-3223(97)00200-X  0.347
1998 Modell S, Lauer CJ, Schreiber W, Huber J, Krieg JC, Holsboer F. Hormonal response pattern in the combined DEX-CRH test is stable over time in subjects at high familial risk for affective disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 18: 253-62. PMID 9509493 DOI: 10.1016/S0893-133X(97)00144-9  0.392
1998 Wiedemann K, Lauer CJ, Hirschmann M, Knaudt K, Holsboer F. Sleep-endocrine effects of mifepristone and megestrol acetate in healthy men American Journal of Physiology - Endocrinology and Metabolism. 274. PMID 9458759 DOI: 10.1152/Ajpendo.1998.274.1.E139  0.318
1998 Wiedemann K, Holsboer F. The effect of repeated human corticotropin-releasing hormone administration on dexamethasone-suppressed pituitary-adrenocortical activity in healthy subjects. Biological Psychiatry. 42: 882-8. PMID 9359973 DOI: 10.1016/S0006-3223(96)00434-9  0.336
1998 Dijkstra I, Tilders FJH, Aguilera G, Kiss A, Rabadan-Diehl C, Barden N, Karanth S, Holsboer F, Reul JMHM. Reduced Activity of Hypothalamic Corticotropin-Releasing Hormone Neurons in Transgenic Mice with Impaired Glucocorticoid Receptor Function The Journal of Neuroscience. 18: 3909-3918. DOI: 10.1523/Jneurosci.18-10-03909.1998  0.336
1997 Guldner J, Schier T, Friess E, Colla M, Holsboer F, Steiger A. Reduced efficacy of growth hormone-releasing hormone in modulating sleep endocrine activity in the elderly. Neurobiology of Aging. 18: 491-5. PMID 9390775 DOI: 10.1016/S0197-4580(97)00106-1  0.32
1997 Barden N, Stec IS, Montkowski A, Holsboer F, Reul JM. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology. 66: 212-20. PMID 9380279 DOI: 10.1159/000127240  0.329
1997 Steiger A, Holsboer F. Nocturnal secretion of prolactin and cortisol and the sleep EEG in patients with major endogenous depression during an acute episode and after full remission. Psychiatry Research. 72: 81-8. PMID 9335199 DOI: 10.1016/S0165-1781(97)00097-8  0.371
1997 Bohlhalter S, Murck H, Holsboer F, Steiger A. Cortisol enhances non-REM sleep and growth hormone secretion in elderly subjects. Neurobiology of Aging. 18: 423-9. PMID 9330974 DOI: 10.1016/S0197-4580(97)00036-5  0.326
1997 Karanth S, Linthorst AC, Stalla GK, Barden N, Holsboer F, Reul JM. Hypothalamic-pituitary-adrenocortical axis changes in a transgenic mouse with impaired glucocorticoid receptor function. Endocrinology. 138: 3476-85. PMID 9231802 DOI: 10.1210/Endo.138.8.5331  0.348
1997 Friess E, Tagaya H, Trachsel L, Holsboer F, Rupprecht R. Progesterone-induced changes in sleep in male subjects. The American Journal of Physiology. 272: E885-91. PMID 9176190 DOI: 10.1152/Ajpendo.1997.272.5.E885  0.3
1997 Sonntag A, Rothe B, Guldner J, Yassouridis A, Holsboer F, Steiger A. Trimipramine and imipramine exert different effects on the sleep EEG and on nocturnal hormone secretion during treatment of major depression. Depression. 4: 1-13. PMID 9160649 DOI: 10.1002/(Sici)1522-7162(1996)4:1<1::Aid-Depr1>3.0.Co;2-S  0.34
1997 Kellner M, Yassouridis A, Manz B, Steiger A, Holsboer F, Wiedemann K. Corticotropin-releasing hormone inhibits melatonin secretion in healthy volunteers--a potential link to low-melatonin syndrome in depression? Neuroendocrinology. 65: 284-90. PMID 9143000 DOI: 10.1159/000127186  0.399
1997 Lauer CJ, Bronisch T, Kainz M, Schreiber W, Holsboer F, Krieg JC. Pre-morbid psychometric profile of subjects at high familial risk for affective disorder. Psychological Medicine. 27: 355-62. PMID 9089828 DOI: 10.1017/S0033291796004400  0.321
1997 Schier T, Guldner J, Colla M, Holsboer F, Steiger A. Changes in sleep-endocrine activity after growth hormone-releasing hormone depend on time of administration. Journal of Neuroendocrinology. 9: 201-5. PMID 9089471 DOI: 10.1046/J.1365-2826.1997.00565.X  0.352
1997 Modell S, Yassouridis A, Huber J, Holsboer F. Corticosteroid receptor function is decreased in depressed patients. Neuroendocrinology. 65: 216-22. PMID 9088003 DOI: 10.1159/000127275  0.354
1997 Reul JM, Probst JC, Skutella T, Hirschmann M, Stec IS, Montkowski A, Landgraf R, Holsboer F. Increased stress-induced adrenocorticotropin response after long-term intracerebroventricular treatment of rats with antisense mineralocorticoid receptor oligodeoxynucleotides. Neuroendocrinology. 65: 189-99. PMID 9088000 DOI: 10.1159/000127272  0.332
1997 Patchev VK, Montkowski A, Rouskova D, Koranyi L, Holsboer F, Almeida OF. Neonatal treatment of rats with the neuroactive steroid tetrahydrodeoxycorticosterone (THDOC) abolishes the behavioral and neuroendocrine consequences of adverse early life events. The Journal of Clinical Investigation. 99: 962-6. PMID 9062354 DOI: 10.1172/Jci119261  0.359
1997 Almeida OF, Canoine V, Ali S, Holsboer F, Patchev VK. Activational effects of gonadal steroids on hypothalamo-pituitary-adrenal regulation in the rat disclosed by response to dexamethasone suppression. Journal of Neuroendocrinology. 9: 129-34. PMID 9041366 DOI: 10.1046/J.1365-2826.1997.00556.X  0.341
1997 Schreiber W, Lauer CJ, Krumrey K, Holsboer F, Krieg JC. Dysregulation of the hypothalamic-pituitary-adrenocortical system in panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 7-15. PMID 8797187 DOI: 10.1016/0893-133X(95)00146-5  0.348
1997 Linthorst ACE, Flachskamm C, Hopkins SJ, Hoadley ME, Labeur MS, Holsboer F, Reul JMHM. Long-Term Intracerebroventricular Infusion of Corticotropin-Releasing Hormone Alters Neuroendocrine, Neurochemical, Autonomic, Behavioral, and Cytokine Responses to a Systemic Inflammatory Challenge The Journal of Neuroscience. 17: 4448-4460. DOI: 10.1523/Jneurosci.17-11-04448.1997  0.331
1997 Hatzinger M, Landgraf R, Holsboer F, Holsboer-Trachsier E, Neumann I. Involvement of Vasopressin in Hypothalamic-Pituitary-Adrenal (HPA) System Alterations European Psychiatry. 12: 175s-175s. DOI: 10.1016/S0924-9338(97)80515-9  0.321
1996 Trapp T, Holsboer F. Heterodimerization between mineralocorticoid and glucocorticoid receptors increases the functional diversity of corticosteroid action. Trends in Pharmacological Sciences. 17: 145-9. PMID 8984741 DOI: 10.1016/0165-6147(96)81590-2  0.305
1996 Hatzinger M, Reul JM, Landgraf R, Holsboer F, Neumann I. Combined dexamethasone/CRH test in rats: hypothalamo-pituitary-adrenocortical system alterations in aging. Neuroendocrinology. 64: 349-56. PMID 8930935 DOI: 10.1159/000127138  0.334
1996 Hartmann A, Krumrey K, Vogl L, Dirlich G, Holsboer F, Heuser-Link M. Changes in late auditory evoked potentials induced by corticotropin-releasing hormone and corticotropin fragment 4-9 in male controls. Neuropsychobiology. 33: 90-6. PMID 8927235 DOI: 10.1159/000119256  0.314
1996 Wotjak CT, Kubota M, Liebsch G, Montkowski A, Holsboer F, Neumann I, Landgraf R. Release of vasopressin within the rat paraventricular nucleus in response to emotional stress: a novel mechanism of regulating adrenocorticotropic hormone secretion? The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7725-32. PMID 8922428 DOI: 10.1523/Jneurosci.16-23-07725.1996  0.326
1996 Murck H, Guldner J, Colla-Müller M, Frieboes RM, Schier T, Wiedemann K, Holsboer F, Steiger A. VIP decelerates non-REM-REM cycles and modulates hormone secretion during sleep in men. The American Journal of Physiology. 271: R905-11. PMID 8897980 DOI: 10.1152/Ajpregu.1996.271.4.R905  0.311
1996 Lancel M, Faulhaber J, Holsboer F, Rupprecht R. Progesterone induces changes in sleep comparable to those of agonistic GABAA receptor modulators. The American Journal of Physiology. 271: E763-72. PMID 8897866 DOI: 10.1152/Ajpendo.1996.271.4.E763  0.319
1996 Guldner J, Trachsel L, Kratschmayr C, Rothe B, Holsboer F, Steiger A. Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men. Psychopharmacology. 122: 115-21. PMID 8848526 DOI: 10.1007/Bf02246085  0.304
1996 Engelmann M, Thrivikraman KV, Su Y, Nemeroff CB, Montkowski A, Landgraf R, Holsboer F, Plotsky PM. Endocrine and behavioral effects of airpuff-startle in rats. Psychoneuroendocrinology. 21: 391-400. PMID 8844877 DOI: 10.1016/0306-4530(96)00006-6  0.318
1996 Rupprecht R, Berning B, Hauser CA, Holsboer F, Reul JM. Steroid receptor-mediated effects of neuroactive steroids: characterization of structure-activity relationship. European Journal of Pharmacology. 303: 227-34. PMID 8813574 DOI: 10.1016/0014-2999(96)00036-2  0.308
1996 Kellner M, Holsboer F, Heuser I. Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression. Psychiatry Research. 59: 157-60. PMID 8771231 DOI: 10.1016/0165-1781(96)81880-4  0.352
1996 Grasser A, Möller A, Backmund H, Yassouridis A, Holsboer F. Heterogeneity of hypothalamic-pituitary-adrenal system response to a combined dexamethasone-CRH test in multiple sclerosis. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association. 104: 31-7. PMID 8750568 DOI: 10.1055/S-0029-1211419  0.333
1996 Linthorst AC, Flachskamm C, Holsboer F, Reul JM. Activation of serotonergic and noradrenergic neurotransmission in the rat hippocampus after peripheral administration of bacterial endotoxin: involvement of the cyclo-oxygenase pathway. Neuroscience. 72: 989-97. PMID 8735224 DOI: 10.1016/0306-4522(95)00604-4  0.302
1996 Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocrine Reviews. 17: 187-205. PMID 8706631 DOI: 10.1210/Edrv-17-2-187  0.36
1996 Rupprecht R, Hauser CA, Trapp T, Holsboer F. Neurosteroids: molecular mechanisms of action and psychopharmacological significance. The Journal of Steroid Biochemistry and Molecular Biology. 56: 163-8. PMID 8603037 DOI: 10.1016/0960-0760(95)00233-2  0.332
1996 Heuser IJ, Schweiger U, Gotthardt U, Schmider J, Lammers CH, Dettling M, Yassouridis A, Holsboer F. Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. The American Journal of Psychiatry. 153: 93-9. PMID 8540599 DOI: 10.1176/Ajp.153.1.93  0.345
1996 Raiden S, Polack E, Nahmod V, Labeur M, Holsboer F, Arzt E. TRH receptor on immune cells: in vitro and in vivo stimulation of human lymphocyte and rat splenocyte DNA synthesis by TRH. Journal of Clinical Immunology. 15: 242-9. PMID 8537468 DOI: 10.1007/Bf01540881  0.307
1995 Lammers C, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F, Heuser IJE. Combined dexamethasone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II. Biological Psychiatry. 38: 803-807. PMID 8750038 DOI: 10.1016/0006-3223(95)00065-8  0.304
1995 Schmider J, Lammers C, Gotthardt U, Dettling M, Holsboer F, Heuser IJE. Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression and in normal controls: I Biological Psychiatry. 38: 797-802. PMID 8750037 DOI: 10.1016/0006-3223(95)00064-X  0.357
1995 Montkowski A, Barden N, Wotjak C, Stec I, Ganster J, Meaney M, Engelmann M, Reul JM, Landgraf R, Holsboer F. Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. Journal of Neuroendocrinology. 7: 841-5. PMID 8748120 DOI: 10.1111/J.1365-2826.1995.Tb00724.X  0.356
1995 Liebsch G, Landgraf R, Gerstberger R, Probst JC, Wotjak CT, Engelmann M, Holsboer F, Montkowski A. Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats Regulatory Peptides. 59: 229-239. PMID 8584759 DOI: 10.1016/0167-0115(95)00099-W  0.321
1995 Holsboer F, Lauer CJ, Schreiber W, Krieg JC. Altered hypothalamic-pituitary-adrenocortical regulation in healthy subjects at high familial risk for affective disorders Neuroendocrinology. 62: 340-347. PMID 8544947 DOI: 10.1159/000127023  0.372
1995 Heuser I, Yassouridis A, Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. Journal of Psychiatric Research. 28: 341-56. PMID 7877114 DOI: 10.1016/0022-3956(94)90017-5  0.317
1995 Steiger A, Guldner J, Lauer CJ, Meschenmoser C, Pollmächer T, Holsboer F. Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls. Psychopharmacology. 113: 334-8. PMID 7862842 DOI: 10.1007/Bf02245206  0.335
1995 Skutella T, Stöhr T, Probst JC, Ramalho-Ortigao FJ, Holsboer F, Jirikowski GF. Antisense oligodeoxynucleotides for in vivo targeting of corticotropin-releasing hormone mRNA: comparison of phosphorothioate and 3'-inverted probe performance. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 26: 460-4. PMID 7851868 DOI: 10.1055/S-2007-1001733  0.329
1995 Lauer CJ, Schreiber W, Holsboer F, Krieg JC. In Quest of Identifying Vulnerability Markers for Psychiatric Disorders by All-Night Polysomnography Archives of General Psychiatry. 52: 145-153. PMID 7848050 DOI: 10.1001/Archpsyc.1995.03950140063009  0.341
1995 Rothe B, Guldner J, Hohlfeldt E, Lauer CJ, Pollmächer T, Holsboer F, Steiger A. Effects of 5HT3 receptor antagonism by tropisetron on the sleep EEG and on nocturnal hormone secretion. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 11: 101-6. PMID 7840861 DOI: 10.1038/Npp.1994.39  0.315
1995 Friess E, Trachsel L, Guldner J, Schier T, Steiger A, Holsboer F. DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range. The American Journal of Physiology. 268: E107-13. PMID 7840167 DOI: 10.1152/Ajpendo.1995.268.1.E107  0.305
1995 Steiger A, Benkert O, Holsboer F. Effects of long-term treatment with the MAO-A inhibitor moclobemide on sleep EEG and nocturnal hormonal secretion in normal men. Neuropsychobiology. 30: 101-5. PMID 7800155 DOI: 10.1159/000119145  0.318
1995 Landgraf R, Gerstberger R, Montkowski A, Probst JC, Wotjak CT, Holsboer F, Engelmann M. V1 vasopressin receptor antisense oligodeoxynucleotide into septum reduces vasopressin binding, social discrimination abilities, and anxiety-related behavior in rats Journal of Neuroscience. 15: 4250-4258. PMID 7790909 DOI: 10.1523/Jneurosci.15-06-04250.1995  0.314
1995 Sauer J, Polack E, Wikinski S, Holsboer F, Stalla GK, Arzt E. The glucocorticoid sensitivity of lymphocytes changes according to the activity of the hypothalamic-pituitary-adrenocortical system. Psychoneuroendocrinology. 20: 269-80. PMID 7777655 DOI: 10.1016/0306-4530(94)00058-I  0.31
1995 Labeur MS, Arzt E, Wiegers GJ, Holsboer F, Reul JM. Long-term intracerebroventricular corticotropin-releasing hormone administration induces distinct changes in rat splenocyte activation and cytokine expression. Endocrinology. 136: 2678-88. PMID 7750492 DOI: 10.1210/Endo.136.6.7750492  0.303
1995 Gotthardt U, Schweiger U, Fahrenberg J, Lauer CJ, Holsboer F, Heuser I. Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression. The American Journal of Physiology. 268: R865-73. PMID 7733395 DOI: 10.1152/Ajpregu.1995.268.4.R865  0.348
1995 Kellner M, Herzog L, Holsboer F, Wiedemann K. Circadian changes in the sensitivity of the corticotropin-releasing hormone-stimulated HPA system after arginine vasopressin and atrial natriuretic hormone in human male controls. Psychoneuroendocrinology. 20: 515-24. PMID 7675936 DOI: 10.1016/0306-4530(94)00070-Q  0.33
1995 Kellner M, Herzog L, Yassouridis A, Holsboer F, Wiedemann K. Possible role of atrial natriuretic hormone in pituitary-adrenocortical unresponsiveness in lactate-induced panic. The American Journal of Psychiatry. 152: 1365-7. PMID 7653695 DOI: 10.1176/Ajp.152.9.1365  0.33
1995 Castrén M, Patchev VK, Almeida OF, Holsboer F, Trapp T, Castrén E. Regulation of rat mineralocorticoid receptor expression in neurons by progesterone. Endocrinology. 136: 3800-6. PMID 7649087 DOI: 10.1210/Endo.136.9.7649087  0.32
1995 Skutella T, Montkowski A, Stöhr T, Probst JC, Landgraf R, Holsboer F, Jirikowski GF. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide treatment attenuates social defeat-induced anxiety in rats. Cellular and Molecular Neurobiology. 14: 579-88. PMID 7621515 DOI: 10.1007/Bf02088839  0.319
1995 Frieboes RM, Murck H, Maier P, Schier T, Holsboer F, Steiger A. Growth hormone-releasing peptide-6 stimulates sleep, growth hormone, ACTH and cortisol release in normal man. Neuroendocrinology. 61: 584-9. PMID 7617137 DOI: 10.1159/000126883  0.324
1995 Barden N, Reul JM, Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends in Neurosciences. 18: 6-11. PMID 7535490 DOI: 10.1016/0166-2236(95)93942-Q  0.396
1995 Friess E, Wiedemann K, Steiger A, Holsboer F. The hypothalamic-pituitary-adrenocortical system and sleep in man. Advances in Neuroimmunology. 5: 111-25. PMID 7496607 DOI: 10.1016/0960-5428(95)00003-K  0.309
1994 Friess E, V Bardeleben U, Wiedemann K, Lauer CJ, Holsboer F. Effects of pulsatile cortisol infusion on sleep-EEG and nocturnal growth hormone release in healthy men. Journal of Sleep Research. 3: 73-79. PMID 10607111 DOI: 10.1111/J.1365-2869.1994.Tb00110.X  0.324
1994 Schreiber W, Pollmächer T, Fassbender K, Gudewill S, Vedder H, Wiedemann K, Galanos C, Holsboer F. Endotoxin- and corticotropin-releasing hormone-induced release of ACTH and cortisol. A comparative study in men. Neuroendocrinology. 58: 123-8. PMID 8264845 DOI: 10.1159/000126526  0.315
1994 Schöbitz B, Holsboer F, Sutanto W, Gross G, Schönbaum E, de Kloet ER. Corticosterone modulates interleukin-evoked fever in the rat. Neuroendocrinology. 59: 387-95. PMID 8202220 DOI: 10.1159/000126682  0.471
1994 Reul JM, Stec I, Wiegers GJ, Labeur MS, Linthorst AC, Arzt E, Holsboer F. Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats. The Journal of Clinical Investigation. 93: 2600-7. PMID 8200998 DOI: 10.1172/Jci117272  0.321
1994 Wiedemann K, Lauer C, Pollmächer T, Holsboer F. Sleep endocrine effects of antigluco- and antimineralocorticoids in healthy males. The American Journal of Physiology. 267: E109-14. PMID 8048498 DOI: 10.1152/Ajpendo.1994.267.1.E109  0.349
1994 Wiegers GJ, Reul JM, Holsboer F, de Kloet ER. Enhancement of rat splenic lymphocyte mitogenesis after short term preexposure to corticosteroids in vitro. Endocrinology. 135: 2351-7. PMID 7988417 DOI: 10.1210/Endo.135.6.7988417  0.511
1994 Schöbitz B, Sutanto W, Carey MP, Holsboer F, de Kloet ER. Endotoxin and interleukin 1 decrease the affinity of hippocampal mineralocorticoid (type I) receptor in parallel to activation of the hypothalamic-pituitary-adrenal axis. Neuroendocrinology. 60: 124-33. PMID 7969769 DOI: 10.1159/000126742  0.52
1994 Schöbitz B, De Kloet ER, Holsboer F. Gene expression and function of interleukin 1, interleukin 6 and tumor necrosis factor in the brain. Progress in Neurobiology. 44: 397-432. PMID 7886232 DOI: 10.1016/0301-0082(94)90034-5  0.467
1994 Skutella T, Criswell H, Moy S, Probst JC, Breese GR, Jirikowski GF, Holsboer F. Corticotropin-releasing hormone (CRH) antisense oligodeoxynucleotide induces anxiolytic effects in rat. Neuroreport. 5: 2181-5. PMID 7865772 DOI: 10.1097/00001756-199410270-00048  0.323
1994 Reul JM, Labeur MS, Grigoriadis DE, De Souza EB, Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology. 60: 509-19. PMID 7845541 DOI: 10.1159/000126788  0.367
1994 Holsboer F, Grasser A, Friess E, Wiedemann K. Steroid effects on central neurons and implications for psychiatric and neurological disorders. Annals of the New York Academy of Sciences. 746: 345-59; discussion 3. PMID 7825889 DOI: 10.1111/J.1749-6632.1994.Tb39255.X  0.4
1994 Patchev VK, Shoaib M, Holsboer F, Almeida OFX. The neurosteroid tetrahydroprogesterone counteracts corticotropin-releasing hormone-induced anxiety and alters the release and gene expression of corticotropin-releasing hormone in the rat hypothalamus Neuroscience. 62: 265-271. PMID 7816204 DOI: 10.1016/0306-4522(94)90330-1  0.334
1994 Sonntag A, Colla-M¨ller M, Friess E, Guldner J, Holsboer F, Schier T, Stegier A. Sleep-Endocrine Effects of Growth Hormone-Releasing Hormone (GHRH) in Major Depression Neuropsychopharmacology. 11: 286-286. DOI: 10.1038/Sj.Npp.1380216  0.367
1993 Steiger A, Holsboer F, Benkert O. Studies of nocturnal penile tumescence and sleep electroencephalogram in patients with major depression and in normal controls. Acta Psychiatrica Scandinavica. 87: 358-63. PMID 8517177 DOI: 10.1111/J.1600-0447.1993.Tb03387.X  0.359
1993 Schöbitz B, Van Den Dobbelsteen M, Holsboer F, Sutanto W, De Kloet ER. Regulation of interleukin 6 gene expression in rat. Endocrinology. 132: 1569-76. PMID 8462455 DOI: 10.1210/endo.132.4.8462455  0.408
1993 Steiger A, von Bardeleben U, Guldner J, Lauer C, Rothe B, Holsboer F. The sleep EEG and nocturnal hormonal secretion studies on changes during the course of depression and on effects of CNS-active drugs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 17: 125-37. PMID 8416599 DOI: 10.1016/0278-5846(93)90037-S  0.362
1993 Rupprecht R, Reul JM, Trapp T, van Steensel B, Wetzel C, Damm K, Zieglgänsberger W, Holsboer F. Progesterone receptor-mediated effects of neuroactive steroids. Neuron. 11: 523-30. PMID 8398145 DOI: 10.1016/0896-6273(93)90156-L  0.303
1993 Spengler D, Waeber C, Pantaloni C, Holsboer F, Bockaert J, Seeburg PH, Journot L. Differential signal transduction by five splice variants of the PACAP receptor. Nature. 365: 170-5. PMID 8396727 DOI: 10.1038/365170A0  0.314
1993 Steiger A, Trachsel L, Guldner J, Hemmeter U, Rothe B, Rupprecht R, Vedder H, Holsboer F. Neurosteroid pregnenolone induces sleep-EEG changes in man compatible with inverse agonistic GABAA-receptor modulation. Brain Research. 615: 267-74. PMID 8395958 DOI: 10.1016/0006-8993(93)90037-N  0.35
1993 Reul JM, Stec I, Söder M, Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology. 133: 312-20. PMID 8391426 DOI: 10.1210/Endo.133.1.8391426  0.326
1993 Steiger A, Gerken A, Benkert O, Holsboer F. Differential effects of the enantiomers R(-) and S(+) oxaprotiline on major endogenous depression, the sleep EEG and neuroendocrine secretion: studies on depressed patients and normal controls. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 3: 117-26. PMID 8364347 DOI: 10.1016/0924-977X(93)90263-L  0.334
1993 Steiger A, Rupprecht R, Spengler D, Guldner J, Hemmeter U, Rothe B, Damm K, Holsboer F. Functional properties of deoxycorticosterone and spironolactone: Molecular characterization and effects on sleep-endocrine activity Journal of Psychiatric Research. 27: 275-284. PMID 8295159 DOI: 10.1016/0022-3956(93)90038-4  0.335
1993 Schöbitz B, de Kloet ER, Sutanto W, Holsboer F. Cellular localization of interleukin 6 mRNA and interleukin 6 receptor mRNA in rat brain. The European Journal of Neuroscience. 5: 1426-35. PMID 8287192 DOI: 10.1111/J.1460-9568.1993.Tb00210.X  0.473
1993 Rupprecht R, Reul JM, van Steensel B, Spengler D, Söder M, Berning B, Holsboer F, Damm K. Pharmacological and functional characterization of human mineralocorticoid and glucocorticoid receptor ligands. European Journal of Pharmacology. 247: 145-54. PMID 8282004 DOI: 10.1016/0922-4106(93)90072-H  0.3
1993 Wiegers GJ, Croiset G, Reul JM, Holsboer F, de Kloet ER. Differential effects of corticosteroids on rat peripheral blood T-lymphocyte mitogenesis in vivo and in vitro. The American Journal of Physiology. 265: E825-30. PMID 8279536 DOI: 10.1152/Ajpendo.1993.265.6.E825  0.493
1993 Vedder H, Parlow F, Zieglgansberger W, Holsboer F. Neurosteroids do not regulate proopiomelanocortin-gene expression in pituitary cells Experimental and Clinical Endocrinology. 101: 161-165. PMID 8223985 DOI: 10.1055/S-0029-1211224  0.311
1993 Garcia-Borreguero D, Lauer CJ, Ozdaglar A, Wiedemann K, Holsboer F, Krieg JC. Brofaromine in panic disorder: a pilot study with a new reversible inhibitor of monoamine oxidase-A. Pharmacopsychiatry. 25: 261-4. PMID 1494591 DOI: 10.1055/S-2007-1014418  0.333
1993 Lauer CJ, Krieg JC, Garcia-Borreguero D, Ozdaglar A, Holsboer F. Panic disorder and major depression: a comparative electroencephalographic sleep study. Psychiatry Research. 44: 41-54. PMID 1461946 DOI: 10.1016/0165-1781(92)90068-E  0.364
1993 Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. Effects of growth hormone-releasing hormone and somatostatin on sleep EEG and nocturnal hormone secretion in male controls. Neuroendocrinology. 56: 566-73. PMID 1361964 DOI: 10.1159/000126275  0.33
1993 Holsboer F, Spengler D, Heuser I. The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Progress in Brain Research. 93: 385-417. PMID 1336204 DOI: 10.1016/S0079-6123(08)64586-0  0.337
1993 HEUSER I, HEUSER-LINK M, GOTTHARDT U, GRASSER A, HOLSBOER F. Behavioral Effects of a Synthetic Corticotropin 4???9 Analog in Patients with Depression and Patients with Alzheimer??s Disease Journal of Clinical Psychopharmacology. 13: 171???174. DOI: 10.1097/00004714-199306000-00003  0.327
1993 Steiger A, Sonntag A, Guldner J, Rothe B, Holsboer F. Changes in clinical symptoms, sleep EEG and nocturnal hormone secretion during treatment with trimipramine or imipramine — a double-blind comparison in patients with major depression European Neuropsychopharmacology. 3: 339-340. DOI: 10.1016/0924-977X(93)90119-7  0.348
1992 Steiger A, Guldner J, Knisatschek H, Rothe B, Lauer C, Holsboer F. Effects of an ACTH/MSH(4-9) analog (HOE 427) on the sleep EEG and nocturnal hormonal secretion in humans. Peptides. 12: 1007-10. PMID 1666179 DOI: 10.1016/0196-9781(91)90051-P  0.321
1992 Wiedemann K, Lauer C, Loycke A, Pollmächer T, Durst P, Machér JP, Holsboer F. Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern. European Archives of Psychiatry and Clinical Neuroscience. 241: 372-5. PMID 1324011 DOI: 10.1007/Bf02191963  0.315
1992 Schöbitz B, Holsboer F, Kikkert R, Sutanto W, De Kloet ER. Peripheral and central regulation of IL-6 gene expression in endotoxin-treated rats. Endocrine Regulations. 26: 103-9. PMID 1308153  0.419
1992 Steiger A, Guldner J, Hemmeter U, Knisatschek H, Rothe B, Rupprecht R, Holsboer F. EFFECTS OF MINERALOCORTICOID RECEPTOR LIGANDS ON SLEEP EEG AND NOCTURNAL HORMONE SECRETION - STUDIES WITH DEOXYCORTICOSTERONE AND SPIRONOLACTONE Clinical Neuropharmacology. 15: 281B. DOI: 10.1097/00002826-199202001-00542  0.315
1992 Guldner J, Steiger A, Rothe B, Holsboer F. INFLUENCE OF THE PARTIAL BENZODIAZEPINE AGONIST BETAZENIL ON SLEEP-EEG AND NOCTURNAL SECRETION OF CORTISOL AND GROWTH HORMONE Clinical Neuropharmacology. 15: 28B. DOI: 10.1097/00002826-199202001-00052  0.307
1991 Krieg JC, Lauer CJ, Hermle L, von Bardeleben U, Pollmächer T, Holsboer F. Psychometric, polysomnographic, and neuroendocrine measures in subjects at high risk for psychiatric disorders: preliminary results. Neuropsychobiology. 23: 57-67. PMID 2077434 DOI: 10.1159/000119428  0.307
1991 Steiger A, Bardeleben Uv, Wiedemann K, Holsboer F. Sleep EEG and nocturnal secretion of testosterone and cortisol in patients with major endogenous depression during acute phase and after remission Journal of Psychiatric Research. 25: 169-177. PMID 1779414 DOI: 10.1016/0022-3956(91)90021-2  0.373
1991 Heuser IJ, Wark HJ, Keul J, Holsboer F. Hypothalamic-pituitary-adrenal axis function in elderly endurance athletes. The Journal of Clinical Endocrinology and Metabolism. 73: 485-8. PMID 1651955 DOI: 10.1210/Jcem-73-3-485  0.372
1991 Heuser I, Grasser A, Gotthardt U, Schmider J, Holsboer F. Psychopathological, cognitive and neuroendocrine responses to treatment with amitriptyline in elderly depressed patients European Neuropsychopharmacology. 1: 327-328. DOI: 10.1016/0924-977X(91)90549-A  0.307
1990 Steiger A, Benkert O, Wöhrmann S, Steinseifer D, Holsboer F. Effects of trimipramine on sleep EEG, penile tumescence and nocturnal hormonal secretion. A long-term study in 3 normal controls. Neuropsychobiology. 21: 71-5. PMID 2515468 DOI: 10.1159/000118555  0.339
1989 Holsboer-Trachsler E, Wiedemann K, Holsboer F. Serial partial sleep deprivation in depression--clinical effects and dexamethasone suppression test results. Neuropsychobiology. 19: 73-8. PMID 3226527 DOI: 10.1159/000118438  0.361
1989 von Bardeleben U, Stalla GK, Müller OA, Holsboer F. Blunting of ACTH response to human CRH in depressed patients is avoided by metyrapone pretreatment. Biological Psychiatry. 24: 782-6. PMID 2852510 DOI: 10.1016/0006-3223(88)90254-5  0.372
1989 Steiger A, Bardeleben Uv, Herth T, Holsboer F. Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery Journal of Affective Disorders. 16: 189-195. PMID 2522118 DOI: 10.1016/0165-0327(89)90073-6  0.351
1988 Holsboer F, Bardeleben Uv, Steiger A. Effects of intravenous corticotropin-releasing hormone upon sleep-related growth hormone surge and sleep EEG in man. Neuroendocrinology. 48: 32-38. PMID 3262835 DOI: 10.1159/000124986  0.324
1987 Philipp M, Maier W, Holsboer F. Psychopathological correlates of plasma cortisol after dexamethasone suppression: a polydiagnostic approach. Psychoneuroendocrinology. 11: 499-507. PMID 3562743 DOI: 10.1016/0306-4530(86)90010-7  0.314
1987 Steiger A, Holsboer F, Benkert O. Effects of brofaremine (CGP 11 305A), a short-acting, reversible, and selective inhibitor of MAO-A on sleep, nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers. Psychopharmacology. 92: 110-4. PMID 3110820 DOI: 10.1007/Bf00215489  0.304
1987 Holsboer F, von Bardeleben U, Wiedemann K, Müller OA, Stalla GK. Serial assessment of corticotropin-releasing hormone response after dexamethasone in depression. Implications for pathophysiology of DST nonsuppression. Biological Psychiatry. 22: 228-34. PMID 3028512 DOI: 10.1016/0006-3223(87)90237-X  0.351
1986 Holsboer F, Wiedemann K, Gerken A, Boll E. The plasma dexamethasone variable in depression: test-retest studies and early biophase kinetics. Psychiatry Research. 17: 97-103. PMID 3961034 DOI: 10.1016/0165-1781(86)90064-8  0.339
1986 Holsboer F, Wiedemann K, Boll E. Shortened dexamethasone half-life in depressed dexamethasone nonsuppressors. Archives of General Psychiatry. 43: 813-5. PMID 3729678 DOI: 10.1001/Archpsyc.1986.01800080099014  0.319
1986 Fichter MM, Pirke KM, Holsboer F. Weight loss causes neuroendocrine disturbances: experimental study in healthy starving subjects. Psychiatry Research. 17: 61-72. PMID 3080766 DOI: 10.1016/0165-1781(86)90042-9  0.346
1986 Gerken A, Holsboer F. Cortisol and corticosterone response after syn-corticotropin in relationship to dexamethasone suppressibility of cortisol. Psychoneuroendocrinology. 11: 185-94. PMID 3018821 DOI: 10.1016/0306-4530(86)90053-3  0.375
1986 Holsboer F, Gerken A, von Bardeleben U, Grimm W, Beyer H, Müller OA, Stalla GK. Human corticotropin-releasing hormone in depression--correlation with thyrotropin secretion following thyrotropin-releasing hormone. Biological Psychiatry. 21: 601-11. PMID 3011129 DOI: 10.1016/0006-3223(86)90121-6  0.369
1986 Holsboer F, Philipp M, Steiger A, Gerken A. Multisteroid analysis after DST in depressed patients--a controlled study. Journal of Affective Disorders. 10: 241-9. PMID 2943779 DOI: 10.1016/0165-0327(86)90011-X  0.339
1985 Gerken A, Maier W, Holsboer F. Weekly monitoring of dexamethasone suppression response in depression: its relationship to change of body weight and psychopathology. Psychoneuroendocrinology. 10: 261-71. PMID 4059474 DOI: 10.1016/0306-4530(85)90003-4  0.322
1985 Bardeleben Uv, Holsboer F, Stalla GK, Müller OA. Combined administration of human corticotropin-releasing factor and lysine vasopressin induces cortisol escape from dexamethasone suppression in healthy subjects. Life Sciences. 37: 1613-1618. PMID 2997567 DOI: 10.1016/0024-3205(85)90480-1  0.358
1985 Holsboer F, Gerken A, Bardeleben UV, Grimm W, Stalla GK, Müller OA. Relationship between pituitary responses to human corticotropin-releasing factor and thyrotropin-releasing hormone in depressives and normal controls. European Journal of Pharmacology. 110: 153-154. PMID 2988980 DOI: 10.1016/0014-2999(85)90046-9  0.332
1985 Holsboer F, Gerken A, Stalla GK, Müller OA. ACTH, cortisol, and corticosterone output after ovine corticotropin-releasing factor challenge during depression and after recovery. Biological Psychiatry. 20: 276-86. PMID 2983788 DOI: 10.1016/0006-3223(85)90057-5  0.365
1984 Holsboer F, Gerken A, Steiger A, Fass V. Mean 14.00-17.00 h plasma cortisol concentration and its relationship to the 1 mg-dexamethasone suppression response in depressives and controls. Acta Psychiatrica Scandinavica. 69: 383-90. PMID 6730994 DOI: 10.1111/J.1600-0447.1984.Tb02509.X  0.371
1984 Holsboer F, Doerr HG, Gerken A, Müller OA, Sippell WG. Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers. Psychiatry Research. 11: 15-23. PMID 6324266 DOI: 10.1016/0165-1781(84)90104-5  0.355
1984 Holsboer F, Gerken A, Steiger A, Benkert O, Müller OA, Stalla GK. Corticotropin-releasing-factor induced pituitary-adrenal response in depression. Lancet (London, England). 1: 55. PMID 6140385 DOI: 10.1016/S0140-6736(84)90225-3  0.347
1984 Holsboer F, Müller OA, Doerr HG, Sippell WG, Stalla GK, Gerken A, Steiger A, Boll E, Benkert O. ACTH and multisteroid responses to corticotropin-releasing factor in depressive illness: relationship to multisteroid responses after ACTH stimulation and dexamethasone suppression. Psychoneuroendocrinology. 9: 147-60. PMID 6089243 DOI: 10.1016/0306-4530(84)90034-9  0.358
1983 Holsboer F, Dörr HG, Sippell WG. Blunted aldosterone response to dexamethasone in female patients with endogenous depression. Psychoneuroendocrinology. 7: 155-62. PMID 7178371 DOI: 10.1016/0306-4530(82)90008-7  0.346
1983 Holsboer F, Winter K, Dörr HG, Sippell WG. Dexamethasone suppression test in female patients with endogenous depression: determinations of plasma corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, cortisol and cortisone. Psychoneuroendocrinology. 7: 329-38. PMID 7167629 DOI: 10.1016/0306-4530(82)90036-1  0.315
1983 Holsboer F, Doerr HG, Sippell WG. Increased sensitivity of the dexamethasone suppression test in depressed female patients based on multisteroid analysis. Psychiatry Research. 8: 49-57. PMID 6572987 DOI: 10.1016/0165-1781(83)90138-5  0.357
1983 Holsboer F, Müller OA, Winter K, Doerr HG, Sippell WG. Effect of serotonin uptake inhibition by zimelidine on hypothalamic-pituitary-adrenal activity. Psychopharmacology. 80: 85-7. PMID 6306711 DOI: 10.1007/Bf00427502  0.338
1982 Holsboer F, Doerr HG, Sippell WG. Dexamethasone suppression of 11-deoxycorticosterone, corticosterone and cortisol in depressed female patients and normal controls. Acta Psychiatrica Scandinavica. 66: 18-25. PMID 7124429 DOI: 10.1111/J.1600-0447.1982.Tb00910.X  0.351
1982 Holsboer F, Liebl R, Hofschuster E. Repeated dexamethasone suppression test during depressive illness. Normalisation of test result compared with clinical improvement. Journal of Affective Disorders. 4: 93-101. PMID 6213695 DOI: 10.1016/0165-0327(82)90039-8  0.347
Low-probability matches (unlikely to be authored by this person)
2010 Lucae S, Ising M, Horstmann S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Domschke K. HTR2A gene variation is involved in antidepressant treatment response. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 65-8. PMID 19758789 DOI: 10.1016/J.Euroneuro.2009.08.006  0.3
2005 Paez-Pereda M, Giacomini D, Echenique C, Stalla GK, Holsboer F, Arzt E. Signaling processes in tumoral neuroendocrine pituitary cells as potential targets for therapeutic drugs. Current Drug Targets. Immune, Endocrine and Metabolic Disorders. 5: 259-67. PMID 16178787 DOI: 10.2174/1568008054863817  0.3
2001 Keck ME, Welt T, Post A, Müller MB, Toschi N, Wigger A, Landgraf R, Holsboer F, Engelmann M. Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 337-49. PMID 11182529 DOI: 10.1016/S0893-133X(00)00191-3  0.3
1998 Lancel M, Mathias S, Schiffelholz T, Behl C, Holsboer F. Soluble tumor necrosis factor receptor (p75) does not attenuate the sleep changes induced by lipopolysaccharide in the rat during the dark period. Brain Research. 770: 184-91. PMID 9372218 DOI: 10.1016/S0006-8993(97)00783-X  0.3
2000 Auer DP, Pütz B, Kraft E, Lipinski B, Schill J, Holsboer F. Reduced glutamate in the anterior cingulate cortex in depression: An in vivo proton magnetic resonance spectroscopy study Biological Psychiatry. 47: 305-313. PMID 10686265 DOI: 10.1016/S0006-3223(99)00159-6  0.3
1996 Seifritz E, Hemmeter U, Trachsel L, Lauer CJ, Hatzinger M, Emrich HM, Holsboer F, Holsboer-Trachsler E. Effects of flumazenil on recovery sleep and hormonal secretion after sleep deprivation in male controls. Psychopharmacology. 120: 449-56. PMID 8539326 DOI: 10.1007/Bf02245817  0.3
2003 Mitev YA, Darwish M, Wolf SS, Holsboer F, Almeida OF, Patchev VK. Gender differences in the regulation of 3 alpha-hydroxysteroid dehydrogenase in rat brain and sensitivity to neurosteroid-mediated stress protection. Neuroscience. 120: 541-9. PMID 12890523 DOI: 10.1016/S0306-4522(03)00287-2  0.3
2005 Wochnik GM, Rüegg J, Abel GA, Schmidt U, Holsboer F, Rein T. FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. The Journal of Biological Chemistry. 280: 4609-16. PMID 15591061 DOI: 10.1074/Jbc.M407498200  0.299
1992 Steiger A, Guldner J, Hemmeter U, Rothe B, Wiedemann K, Holsboer F. EFFECTS OF PULSATILE APPLICATION OF GROWTH HORMONE-RELEASING HORMONE (GHRH) AND OF SOMATOSTATIN (SRIF) ON SLEEP EEG AND ON NOCTURNAL RELEASE OF GROWTH HORMONE AND CORTISOL Clinical Neuropharmacology. 15: 74B. DOI: 10.1097/00002826-199202001-00142  0.299
1992 Wiedemann K, Kellner M, Krieg J, Holsboer F. EFFECTS OF THE DOPAMINE AUTORECEPTOR AGONIST ROXINDOLE IN PATIENTS WITH DEPRESSION Clinical Neuropharmacology. 15: 175B. DOI: 10.1097/00002826-199202001-00338  0.299
1998 Ströhle A, Romeo E, Hermann B, Holsboer F, Runpprecht R. Synthetic pathways of 3α-reduced neuroactive steroids in major depression and after clinical recovery European Neuropsychopharmacology. 8: S179. DOI: 10.1016/S0924-977X(98)80242-3  0.299
2002 Schumann EM, Kümpfel T, Then Bergh F, Trenkwalder C, Holsboer F, Auer DP. Activity of the hypothalamic-pituitary-adrenal axis in multiple sclerosis: correlations with gadolinium-enhancing lesions and ventricular volume. Annals of Neurology. 51: 763-7. PMID 12112083 DOI: 10.1002/Ana.10187  0.299
2011 Filiou MD, Zhang Y, Teplytska L, Reckow S, Gormanns P, Maccarrone G, Frank E, Kessler MS, Hambsch B, Nussbaumer M, Bunck M, Ludwig T, Yassouridis A, Holsboer F, Landgraf R, et al. Proteomics and metabolomics analysis of a trait anxiety mouse model reveals divergent mitochondrial pathways. Biological Psychiatry. 70: 1074-82. PMID 21791337 DOI: 10.1016/J.Biopsych.2011.06.009  0.299
1992 Schreiber W, Lauer CJ, Krumrey K, Holsboer F, Krieg JC. Cholinergic REM sleep induction test in subjects at high risk for psychiatric disorders. Biological Psychiatry. 32: 79-90. PMID 1391297 DOI: 10.1016/0006-3223(92)90144-O  0.299
1999 Stefferl A, Linington C, Holsboer F, Reul JM. Susceptibility and resistance to experimental allergic encephalomyelitis: relationship with hypothalamic-pituitary-adrenocortical axis responsiveness in the rat. Endocrinology. 140: 4932-8. PMID 10537116 DOI: 10.1210/Endo.140.11.7109  0.299
2007 Marsch R, Foeller E, Rammes G, Bunck M, Kössl M, Holsboer F, Zieglgänsberger W, Landgraf R, Lutz B, Wotjak CT. Reduced anxiety, conditioned fear, and hippocampal long-term potentiation in transient receptor potential vanilloid type 1 receptor-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 832-9. PMID 17251423 DOI: 10.1523/Jneurosci.3303-06.2007  0.299
1991 Wiedemann K, Bardeleben Uv, Holsboer F. Influence of human corticotropin-releasing hormone and adrenocorticotropin upon spontaneous growth hormone secretion. Neuroendocrinology. 54: 462-468. PMID 1749461 DOI: 10.1159/000125937  0.298
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