Alan E. Tomkinson - Publications

Affiliations: 
The University of Texas Health Science Center at San Antonio, San Antonio, TX, United States 
Area:
Molecular Biology, Biochemistry

140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Kodavati M, Wang H, Guo W, Mitra J, Hegde PM, Provasek V, Rao VHM, Vedula I, Zhang A, Mitra S, Tomkinson AE, Hamilton DJ, Van Den Bosch L, Hegde ML. FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease. Nature Communications. 15: 2156. PMID 38461154 DOI: 10.1038/s41467-024-45978-6  0.423
2023 Sallmyr A, Khattri Bhandari S, Naila T, Tomkinson AE. Mammalian DNA ligases; roles in maintaining genome integrity. Journal of Molecular Biology. 168276. PMID 37714297 DOI: 10.1016/j.jmb.2023.168276  0.823
2023 Hegde M, Manohar K, Wang H, Gao W, Mitra J, Hegde P, Provasek V, Rao V, Vedula I, Zhang A, Mitra S, Tomkinson A, Bosch LVD, Hamilton D. FUS Unveiled in Mitochondrial DNA Repair and Targeted Ligase-1 Expression Rescues Repair-Defects in FUS-Linked Neurodegeneration. Research Square. PMID 37502965 DOI: 10.21203/rs.3.rs-3152718/v1  0.443
2023 Bilkis R, Lake RJ, Cooper KL, Tomkinson A, Fan HY. The CSB chromatin remodeler regulates PARP1- and PARP2-mediated single-strand break repair at actively transcribed DNA regions. Nucleic Acids Research. PMID 37326017 DOI: 10.1093/nar/gkad515  0.724
2023 Chen S, Vogt A, Lee L, Naila T, McKeown R, Tomkinson AE, Lees-Miller SP, He Y. Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ. Science Advances. 9: eadg2838. PMID 37256947 DOI: 10.1126/sciadv.adg2838  0.741
2023 Bhandari SK, Wiest N, Sallmyr A, Du R, Ferry L, Defossez PA, Tomkinson AE. Unchanged PCNA and DNMT1 dynamics during replication in DNA ligase I-deficient cells but abnormal chromatin levels of non-replicative histone H1. Scientific Reports. 13: 4363. PMID 36928068 DOI: 10.1038/s41598-023-31367-4  0.623
2022 Rashid I, Tsai MS, Sverzhinsky A, Hlaing AS, Shih B, Thwin AC, Lin JG, Maw SS, Pascal JM, Tomkinson AE. Purification and Characterization of Human DNA Ligase IIIα Complexes After Expression in Insect Cells. Methods in Molecular Biology (Clifton, N.J.). 2444: 243-269. PMID 35290642 DOI: 10.1007/978-1-0716-2063-2_15  0.422
2021 Sverzhinsky A, Tomkinson AE, Pascal JM. Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase. Structure (London, England : 1993). PMID 34838188 DOI: 10.1016/j.str.2021.11.002  0.802
2021 Ali R, Alabdullah M, Algethami M, Alblihy A, Miligy I, Shoqafi A, Mesquita KA, Abdel-Fatah T, Chan SY, Chiang PW, Mongan NP, Rakha EA, Tomkinson AE, Madhusudan S. Ligase 1 is a predictor of platinum resistance and its blockade is synthetically lethal in XRCC1 deficient epithelial ovarian cancers. Theranostics. 11: 8350-8361. PMID 34373746 DOI: 10.7150/thno.51456  0.389
2021 Rashid I, Hammel M, Sverzhinsky A, Tsai MS, Pascal JM, Tainer JA, Tomkinson AE. Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus. The Journal of Biological Chemistry. 100921. PMID 34181949 DOI: 10.1016/j.jbc.2021.100921  0.73
2021 Chen S, Lee L, Naila T, Fishbain S, Wang A, Tomkinson AE, Lees-Miller SP, He Y. Structural basis of long-range to short-range synaptic transition in NHEJ. Nature. PMID 33854234 DOI: 10.1038/s41586-021-03458-7  0.788
2020 Hammel M, Rashid I, Sverzhinsky A, Pourfarjam Y, Tsai MS, Ellenberger T, Pascal JM, Kim IK, Tainer JA, Tomkinson AE. An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex. Nucleic Acids Research. PMID 33330937 DOI: 10.1093/nar/gkaa1188  0.604
2020 Zhao B, Naila T, Lieber MR, Tomkinson AE. NAD+ is not utilized as a co-factor for DNA ligation by human DNA ligase IV. Nucleic Acids Research. PMID 33264406 DOI: 10.1093/nar/gkaa1118  0.766
2020 Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE. Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation. Journal of Molecular Biology. PMID 33157085 DOI: 10.1016/j.jmb.2020.10.032  0.75
2020 Sallmyr A, Rashid I, Bhandari SK, Naila T, Tomkinson AE. Human DNA ligases in replication and repair. Dna Repair. 93: 102908. PMID 33087274 DOI: 10.1016/j.dnarep.2020.102908  0.772
2020 Eckelmann BJ, Bacolla A, Wang H, Ye Z, Guerrero EN, Jiang W, El-Zein R, Hegde ML, Tomkinson AE, Tainer JA, Mitra S. XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. Nar Cancer. 2: zcaa013. PMID 32776008 DOI: 10.1093/narcan/zcaa013  0.537
2020 Oh DY, Matsumoto Y, Kitajiri SI, Kim NKD, Young Kim M, Reum Kim A, Lee M, Lee C, Tomkinson AE, Katsuno T, Young Kim S, Shin HW, Hee Han J, Lee S, Park WY, et al. POLD1 variants leading to reduced polymerase activity can cause hearing loss without syndromic features. Human Mutation. PMID 31944473 DOI: 10.1002/humu.23984  0.382
2019 Tomkinson AE, Naila T, Khattri Bhandari S. Altered DNA ligase activity in human disease. Mutagenesis. PMID 31630206 DOI: 10.1093/mutage/gez026  0.813
2019 Roth BM, Varney KM, Yang H, Weber DJ, Tomkinson AE. H, C, and N backbone resonance assignments of the human DNA ligase 3 DNA-binding domain (residues 257-477). Biomolecular Nmr Assignments. PMID 31093909 DOI: 10.1007/S12104-019-09896-9  0.771
2019 Wiest NE, Tomkinson AE. SUMOning the base excision repair machinery for differentiation. The Embo Journal. 38. PMID 30545824 DOI: 10.15252/embj.2018101147  0.326
2018 Wang H, Guo W, Mitra J, Hegde PM, Vandoorne T, Eckelmann BJ, Mitra S, Tomkinson AE, Van Den Bosch L, Hegde ML. Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis. Nature Communications. 9: 3683. PMID 30206235 DOI: 10.1038/S41467-018-06111-6  0.616
2018 Sallmyr A, Tomkinson AE. Repair of DNA double-strand breaks by mammalian alternative end-joining pathways. The Journal of Biological Chemistry. PMID 29530982 DOI: 10.1074/jbc.TM117.000375  0.573
2017 Howes TRL, Sallmyr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Erratum to "Structure-activity relationships among DNA ligase inhibitors; characterization of a selective uncompetitive DNA ligase I inhibitor" [DNA Repair 60C (2017) 29-39]. Dna Repair. PMID 29273192 DOI: 10.1016/J.Dnarep.2017.12.001  0.727
2017 Howes TRL, Sallymr A, Brooks R, Greco GE, Jones DE, Matsumoto Y, Tomkinson AE. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. Dna Repair. 60: 29-39. PMID 29078112 DOI: 10.1016/J.Dnarep.2017.10.002  0.468
2017 Wiest NE, Houghtaling S, Sanchez JC, Tomkinson AE, Osley MA. The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast. Nucleic Acids Research. PMID 28398510 DOI: 10.1093/Nar/Gkx221  0.743
2017 Cannan WJ, Rashid I, Tomkinson AE, Wallace SS, Pederson DS. The Human DNA Ligase IIIα-X-ray Repair Cross-complementing Protein 1 Complex Performs DNA Nick Repair after Transient Unwrapping of Nucleosomal DNA. The Journal of Biological Chemistry. PMID 28184006 DOI: 10.1074/Jbc.M116.736728  0.711
2016 Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA. An Intrinsically Disordered APLF Links Ku, DNA-PKcs and XRCC4-DNA Ligase IV in an Extended Flexible Non-Homologous End Joining Complex. The Journal of Biological Chemistry. PMID 27875301 DOI: 10.1074/Jbc.M116.751867  0.695
2016 Peng Z, Liao Z, Matsumoto Y, Yang A, Tomkinson AE. Human DNA Ligase I Interacts with and is Targeted for Degradation by the DCAF7 Specificity Factor of the CUL4-DDB1 Ubiquitin Ligase Complex. The Journal of Biological Chemistry. PMID 27573245 DOI: 10.1074/Jbc.M116.746198  0.79
2016 Sallmyr A, Matsumoto Y, Roginskaya VY, Van Houten B, Tomkinson AE. Inhibiting mitochondrial DNA ligase IIIα activates caspase 1-dependent apoptosis in cancer cells. Cancer Research. PMID 27503931 DOI: 10.1158/0008-5472.CAN-15-3243  0.44
2016 Greco GE, Matsumoto Y, Brooks RC, Lu Z, Lieber MR, Tomkinson AE. SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV. Dna Repair. 43: 18-23. PMID 27235626 DOI: 10.1016/j.dnarep.2016.04.004  0.755
2016 Slean MM, Panigrahi GB, Castel AL, Pearson AB, Tomkinson AE, Pearson CE. Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks. Dna Repair. PMID 27155933 DOI: 10.1016/J.Dnarep.2016.04.002  0.692
2016 Greco GE, Conrad ZA, Johnston AM, Li Q, Tomkinson AE. Synthesis and structure determination of SCR7, a DNA ligase inhibitor Tetrahedron Letters. 57: 3204-3207. DOI: 10.1016/j.tetlet.2016.06.037  0.533
2015 Hegde PM, Dutta A, Sengupta S, Mitra J, Adhikari S, Tomkinson AE, Li GM, Boldogh I, Hazra TK, Mitra S, Hegde ML. The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant Negative Function of CTD. The Journal of Biological Chemistry. PMID 26134572 DOI: 10.1074/Jbc.M115.642918  0.687
2015 Kukshal V, Kim IK, Hura GL, Tomkinson AE, Tainer JA, Ellenberger T. Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining. Nucleic Acids Research. 43: 7021-31. PMID 26130724 DOI: 10.1093/Nar/Gkv652  0.808
2015 Yang H, Matsumoto Y, Trujillo KM, Lees-Miller SP, Osley MA, Tomkinson AE. Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining. Dna Repair. 31: 1-10. PMID 25942368 DOI: 10.1016/J.Dnarep.2015.04.003  0.744
2015 Matsumoto Y, Rodriguez V, Whitford TA, Beeharry N, Ide H, Tomkinson AE. Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells. Oncoscience. 2: 272-84. PMID 25897430  0.308
2015 Matsumoto Y, Rodriguez V, Whitford TA, Beeharry N, Ide H, Tomkinson AE. Synergistic enhancement of 5-fluorouracil cytotoxicity by deoxyuridine analogs in cancer cells Oncoscience. 2: 272-284. DOI: 10.18632/oncoscience.125  0.307
2014 Ghezraoui H, Piganeau M, Renouf B, Renaud JB, Sallmyr A, Ruis B, Oh S, Tomkinson AE, Hendrickson EA, Giovannangeli C, Jasin M, Brunet E. Chromosomal translocations in human cells are generated by canonical nonhomologous end-joining. Molecular Cell. 55: 829-42. PMID 25201414 DOI: 10.1016/J.Molcel.2014.08.002  0.3
2014 Shanmugam I, Abbas M, Ayoub F, Mirabal S, Bsaili M, Caulder EK, Weinstock DM, Tomkinson AE, Hromas R, Shaheen M. Ubiquitin-specific peptidase 20 regulates Rad17 stability, checkpoint kinase 1 phosphorylation and DNA repair by homologous recombination. The Journal of Biological Chemistry. 289: 22739-48. PMID 24923443 DOI: 10.1074/Jbc.M114.550459  0.725
2013 Tomkinson AE, Howes TR, Wiest NE. DNA ligases as therapeutic targets. Translational Cancer Research. 2. PMID 24224145  0.626
2013 Tomkinson AE, Sallmyr A. Structure and function of the DNA ligases encoded by the mammalian LIG3 gene. Gene. 531: 150-7. PMID 24013086 DOI: 10.1016/j.gene.2013.08.061  0.813
2013 Hegde ML, Hegde PM, Bellot LJ, Mandal SM, Hazra TK, Li GM, Boldogh I, Tomkinson AE, Mitra S. Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: E3090-9. PMID 23898192 DOI: 10.1073/Pnas.1304231110  0.697
2013 Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV. Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene. 32: 1784-93. PMID 22641215 DOI: 10.1038/onc.2012.203  0.597
2012 Della-Maria J, Hegde ML, McNeill DR, Matsumoto Y, Tsai MS, Ellenberger T, Wilson DM, Mitra S, Tomkinson AE. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. The Journal of Biological Chemistry. 287: 39233-44. PMID 22992732 DOI: 10.1074/Jbc.M112.369975  0.773
2012 Peng Z, Liao Z, Dziegielewska B, Matsumoto Y, Thomas S, Wan Y, Yang A, Tomkinson AE. Phosphorylation of serine 51 regulates the interaction of human DNA ligase I with replication factor C and its participation in DNA replication and repair. The Journal of Biological Chemistry. 287: 36711-9. PMID 22952233 DOI: 10.1074/Jbc.M112.383570  0.664
2012 Howes TR, Tomkinson AE. DNA ligase I, the replicative DNA ligase. Sub-Cellular Biochemistry. 62: 327-41. PMID 22918593 DOI: 10.1007/978-94-007-4572-8_17  0.796
2012 Dey S, Maiti AK, Hegde ML, Hegde PM, Boldogh I, Sarkar PS, Abdel-Rahman SZ, Sarker AH, Hang B, Xie J, Tomkinson AE, Zhou M, Shen B, Wang G, Wu C, et al. Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2. Dna Repair. 11: 570-8. PMID 22497777 DOI: 10.1016/J.Dnarep.2012.03.005  0.589
2012 Goula AV, Pearson CE, Della Maria J, Trottier Y, Tomkinson AE, Wilson DM, Merienne K. The nucleotide sequence, DNA damage location, and protein stoichiometry influence the base excision repair outcome at CAG/CTG repeats. Biochemistry. 51: 3919-32. PMID 22497302 DOI: 10.1021/Bi300410D  0.519
2012 Gamper AM, Choi S, Matsumoto Y, Banerjee D, Tomkinson AE, Bakkenist CJ. ATM protein physically and functionally interacts with proliferating cell nuclear antigen to regulate DNA synthesis. The Journal of Biological Chemistry. 287: 12445-54. PMID 22362778 DOI: 10.1074/Jbc.M112.352310  0.746
2012 Tseng HM, Shum D, Bhinder B, Escobar S, Veomett NJ, Tomkinson AE, Gin DY, Djaballah H, Scheinberg DA. A high-throughput scintillation proximity-based assay for human DNA ligase IV. Assay and Drug Development Technologies. 10: 235-49. PMID 22192310 DOI: 10.1089/Adt.2011.0404  0.831
2012 Tobin LA, Robert C, Nagaria P, Chumsri S, Twaddell W, Ioffe OB, Greco GE, Brodie AH, Tomkinson AE, Rassool FV. Targeting abnormal DNA repair in therapy-resistant breast cancers. Molecular Cancer Research : McR. 10: 96-107. PMID 22112941 DOI: 10.1158/1541-7786.MCR-11-0255  0.537
2012 Grob P, Zhang TT, Hannah R, Yang H, Hefferin ML, Tomkinson AE, Nogales E. Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IV. Dna Repair. 11: 74-81. PMID 22088982 DOI: 10.1016/J.Dnarep.2011.10.023  0.813
2011 Odell ID, Barbour JE, Murphy DL, Della-Maria JA, Sweasy JB, Tomkinson AE, Wallace SS, Pederson DS. Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair. Molecular and Cellular Biology. 31: 4623-32. PMID 21930793 DOI: 10.1128/Mcb.05715-11  0.672
2011 Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, Tomkinson AE. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. The Journal of Biological Chemistry. 286: 33845-53. PMID 21816818 DOI: 10.1074/Jbc.M111.274159  0.772
2011 Overmeer RM, Moser J, Volker M, Kool H, Tomkinson AE, van Zeeland AA, Mullenders LH, Fousteri M. Replication protein A safeguards genome integrity by controlling NER incision events. The Journal of Cell Biology. 192: 401-15. PMID 21282463 DOI: 10.1083/Jcb.201006011  0.655
2011 Chen X, Tomkinson AE. Yeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining. The Journal of Biological Chemistry. 286: 4931-40. PMID 21149442 DOI: 10.1074/jbc.M110.195024  0.669
2010 Rassool FV, Tomkinson AE. Targeting abnormal DNA double strand break repair in cancer. Cellular and Molecular Life Sciences : Cmls. 67: 3699-710. PMID 20697770 DOI: 10.1007/s00018-010-0493-5  0.456
2010 Cotner-Gohara E, Kim IK, Hammel M, Tainer JA, Tomkinson AE, Ellenberger T. Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states Biochemistry. 49: 6165-6176. PMID 20518483 DOI: 10.1021/Bi100503W  0.757
2010 Berquist BR, Singh DK, Fan J, Kim D, Gillenwater E, Kulkarni A, Bohr VA, Ackerman EJ, Tomkinson AE, Wilson DM. Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population. Nucleic Acids Research. 38: 5023-35. PMID 20385586 DOI: 10.1093/Nar/Gkq193  0.66
2009 López Castel A, Tomkinson AE, Pearson CE. CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair. The Journal of Biological Chemistry. 284: 26631-45. PMID 19628465 DOI: 10.1074/Jbc.M109.034405  0.724
2009 Chen X, Ballin JD, Della-Maria J, Tsai MS, White EJ, Tomkinson AE, Wilson GM. Distinct kinetics of human DNA ligases I, IIIalpha, IIIbeta, and IV reveal direct DNA sensing ability and differential physiological functions in DNA repair. Dna Repair. 8: 961-8. PMID 19589734 DOI: 10.1016/j.dnarep.2009.06.002  0.796
2009 Song W, Pascal JM, Ellenberger T, Tomkinson AE. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. Dna Repair. 8: 912-9. PMID 19523882 DOI: 10.1016/J.Dnarep.2009.05.002  0.777
2009 Vijayakumar S, Dziegielewska B, Levin DS, Song W, Yin J, Yang A, Matsumoto Y, Bermudez VP, Hurwitz J, Tomkinson AE. Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair. Molecular and Cellular Biology. 29: 2042-52. PMID 19223468 DOI: 10.1128/Mcb.01732-08  0.77
2009 Tobin LA, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV. DNA Ligase III Alpha and (Poly-ADP) Ribose Polymerase (PARP1) Are Therapeutic Targets in Imatinib-Resistant (IR) Chronic Myeloid Leukemia (CML). Blood. 114: 853-853. DOI: 10.1182/blood.v114.22.853.853  0.577
2008 Zhong S, Chen X, Zhu X, Dziegielewska B, Bachman KE, Ellenberger T, Ballin JD, Wilson GM, Tomkinson AE, MacKerell AD. Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design Journal of Medicinal Chemistry. 51: 4553-4562. PMID 18630893 DOI: 10.1021/Jm8001668  0.724
2008 Sallmyr A, Tomkinson AE, Rassool FV. Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks. Blood. 112: 1413-23. PMID 18524993 DOI: 10.1182/blood-2007-07-104257  0.754
2008 Ellenberger T, Tomkinson AE. Eukaryotic DNA ligases: structural and functional insights. Annual Review of Biochemistry. 77: 313-38. PMID 18518823 DOI: 10.1146/Annurev.Biochem.77.061306.123941  0.78
2008 Chen X, Zhong S, Zhu X, Dziegielewska B, Ellenberger T, Wilson GM, MacKerell AD, Tomkinson AE. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair Cancer Research. 68: 3169-3177. PMID 18451142 DOI: 10.1158/0008-5472.Can-07-6636  0.741
2008 Cotner-Gohara E, Kim IK, Tomkinson AE, Ellenberger T. Two DNA-binding and nick recognition modules in human DNA ligase III Journal of Biological Chemistry. 283: 10764-10772. PMID 18238776 DOI: 10.1074/Jbc.M708175200  0.728
2008 Sallmyr A, Tobin L, Tomkinson AE, Rassool FV. Inhibiting Alternative Non Homologus Endjoining (NHEJ) Pathways: Therapeutic Targets in Chronic Myeloid Leukemia (CML). Blood. 112: 1088-1088. DOI: 10.1182/blood.v112.11.1088.1088  0.684
2008 Ellenberger T, Tomkinson AE. Eukaryotic DNA ligases: Structural and functional insights Annual Review of Biochemistry. 77: 313-338. DOI: 10.1146/annurev.biochem.77.061306.123941  0.651
2007 Zhang Y, Hefferin ML, Chen L, Shim EY, Tseng HM, Kwon Y, Sung P, Lee SE, Tomkinson AE. Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination. Nature Structural & Molecular Biology. 14: 639-46. PMID 17589524 DOI: 10.1038/Nsmb1261  0.883
2007 Song W, Levin DS, Varkey J, Post S, Bermudez VP, Hurwitz J, Tomkinson AE. A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. The Journal of Biological Chemistry. 282: 22721-30. PMID 17561505 DOI: 10.1074/Jbc.M703774200  0.818
2007 Vijayakumar S, Chapados BR, Schmidt KH, Kolodner RD, Tainer JA, Tomkinson AE. The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase Nucleic Acids Research. 35: 1624-1637. PMID 17308348 DOI: 10.1093/Nar/Gkm006  0.644
2006 Pascal JM, Tsodikov OV, Hura GL, Song W, Cotner EA, Classen S, Tomkinson AE, Tainer JA, Ellenberger T. A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA. Molecular Cell. 24: 279-91. PMID 17052461 DOI: 10.1016/J.Molcel.2006.08.015  0.768
2006 Dong Z, Tomkinson AE. ATM mediates oxidative stress-induced dephosphorylation of DNA ligase IIIalpha. Nucleic Acids Research. 34: 5721-279. PMID 17040896 DOI: 10.1093/nar/gkl705  0.689
2006 Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells. Dna Repair. 5: 1439-48. PMID 16982218 DOI: 10.1016/J.Dnarep.2006.07.003  0.712
2006 Chen X, Pascal J, Vijayakumar S, Wilson GM, Ellenberger T, Tomkinson AE. Human DNA Ligases I, III, and IV-Purification and New Specific Assays for These Enzymes Methods in Enzymology. 409: 39-52. PMID 16793394 DOI: 10.1016/S0076-6879(05)09003-8  0.8
2006 Tomkinson AE, Vijayakumar S, Pascal JM, Ellenberger T. DNA ligases: structure, reaction mechanism, and function. Chemical Reviews. 106: 687-99. PMID 16464020 DOI: 10.1021/Cr040498D  0.547
2005 Zhang Y, Yuan F, Presnell SR, Tian K, Gao Y, Tomkinson AE, Gu L, Li GM. Reconstitution of 5'-directed human mismatch repair in a purified system. Cell. 122: 693-705. PMID 16143102 DOI: 10.1016/J.Cell.2005.06.027  0.439
2005 Subramanian J, Vijayakumar S, Tomkinson AE, Arnheim N. Genetic instability induced by overexpression of DNA ligase I in budding yeast. Genetics. 171: 427-41. PMID 15965249 DOI: 10.1534/Genetics.105.042861  0.676
2005 Goetz JD, Motycka TA, Han M, Jasin M, Tomkinson AE. Reduced repair of DNA double-strand breaks by homologous recombination in a DNA ligase I-deficient human cell line. Dna Repair. 4: 649-54. PMID 15907772 DOI: 10.1016/J.Dnarep.2005.02.004  0.883
2005 Hefferin ML, Tomkinson AE. Mechanism of DNA double-strand break repair by non-homologous end joining. Dna Repair. 4: 639-48. PMID 15907771 DOI: 10.1016/j.dnarep.2004.12.005  0.735
2005 Okano S, Lan L, Tomkinson AE, Yasui A. Translocation of XRCC1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells. Nucleic Acids Research. 33: 422-9. PMID 15653642 DOI: 10.1093/nar/gki190  0.672
2005 Chen L, Trujillo KM, Van Komen S, Roh DH, Krejci L, Lewis LK, Resnick MA, Sung P, Tomkinson AE. Effect of amino acid substitutions in the rad50 ATP binding domain on DNA double strand break repair in yeast. The Journal of Biological Chemistry. 280: 2620-7. PMID 15546877 DOI: 10.1074/Jbc.M410192200  0.724
2004 Pascal JM, O'Brien PJ, Tomkinson AE, Ellenberger T. Human DNA ligase I completely encircles and partially unwinds nicked DNA. Nature. 432: 473-8. PMID 15565146 DOI: 10.1038/Nature03082  0.815
2004 Levin DS, Vijayakumar S, Liu X, Bermudez VP, Hurwitz J, Tomkinson AE. A conserved interaction between the replicative clamp loader and DNA ligase in eukaryotes: implications for Okazaki fragment joining. The Journal of Biological Chemistry. 279: 55196-201. PMID 15502161 DOI: 10.1074/Jbc.M409250200  0.801
2004 Della M, Palmbos PL, Tseng HM, Tonkin LM, Daley JM, Topper LM, Pitcher RS, Tomkinson AE, Wilson TE, Doherty AJ. Mycobacterial Ku and ligase proteins constitute a two-component NHEJ repair machine. Science (New York, N.Y.). 306: 683-5. PMID 15499016 DOI: 10.1126/science.1099824  0.859
2004 Tseng HM, Tomkinson AE. Processing and joining of DNA ends coordinated by interactions among Dnl4/Lif1, Pol4, and FEN-1. The Journal of Biological Chemistry. 279: 47580-8. PMID 15342630 DOI: 10.1074/jbc.M404492200  0.9
2004 Wiederhold L, Leppard JB, Kedar P, Karimi-Busheri F, Rasouli-Nia A, Weinfeld M, Tomkinson AE, Izumi T, Prasad R, Wilson SH, Mitra S, Hazra TK. AP endonuclease-independent DNA base excision repair in human cells. Molecular Cell. 15: 209-20. PMID 15260972 DOI: 10.1016/J.Molcel.2004.06.003  0.746
2004 Lei X, Zhu Y, Tomkinson A, Sun L. Measurement of DNA mismatch repair activity in live cells. Nucleic Acids Research. 32: e100. PMID 15249596 DOI: 10.1093/Nar/Gnh098  0.463
2004 Fan J, Otterlei M, Wong HK, Tomkinson AE, Wilson DM. XRCC1 co-localizes and physically interacts with PCNA. Nucleic Acids Research. 32: 2193-201. PMID 15107487 DOI: 10.1093/Nar/Gkh556  0.552
2004 Motycka TA, Bessho T, Post SM, Sung P, Tomkinson AE. Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. The Journal of Biological Chemistry. 279: 13634-9. PMID 14734547 DOI: 10.1074/Jbc.M313779200  0.872
2003 Trujillo KM, Roh DH, Chen L, Van Komen S, Tomkinson A, Sung P. Yeast xrs2 binds DNA and helps target rad50 and mre11 to DNA ends. The Journal of Biological Chemistry. 278: 48957-48964. PMID 14522986 DOI: 10.1074/Jbc.M309877200  0.818
2003 Krejci L, Chen L, Van Komen S, Sung P, Tomkinson A. Mending the break: two DNA double-strand break repair machines in eukaryotes. Progress in Nucleic Acid Research and Molecular Biology. 74: 159-201. PMID 14510076 DOI: 10.1016/S0079-6603(03)01013-4  0.787
2003 Post SM, Tomkinson AE, Lee EY. The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase epsilon. Nucleic Acids Research. 31: 5568-75. PMID 14500819 DOI: 10.1093/Nar/Gkg765  0.817
2003 Leppard JB, Dong Z, Mackey ZB, Tomkinson AE. Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair. Molecular and Cellular Biology. 23: 5919-27. PMID 12897160 DOI: 10.1128/Mcb.23.16.5919-5927.2003  0.905
2002 Tseng HM, Tomkinson AE. A physical and functional interaction between yeast Pol4 and Dnl4-Lif1 links DNA synthesis and ligation in nonhomologous end joining. The Journal of Biological Chemistry. 277: 45630-7. PMID 12235149 DOI: 10.1074/Jbc.M206861200  0.9
2001 Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE. Promotion of Dnl4-Catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes Molecular Cell. 8: 1105-1115. PMID 11741545 DOI: 10.1016/S1097-2765(01)00388-4  0.816
2001 Tomkinson AE, Chen L, Dong Z, Leppard JB, Levin DS, Mackey ZB, Motycka TA. Completion of base excision repair by mammalian DNA ligases. Progress in Nucleic Acid Research and Molecular Biology. 68: 151-64. PMID 11554294 DOI: 10.1016/S0079-6603(01)68097-8  0.853
2000 Levin DS, McKenna AE, Motycka TA, Matsumoto Y, Tomkinson AE. Interaction between PCNA and DNA ligase I is critical for joining of Okazaki fragments and long-patch base-excision repair. Current Biology : Cb. 10: 919-22. PMID 10959839 DOI: 10.1016/S0960-9822(00)00619-9  0.87
2000 Chen L, Trujillo K, Sung P, Tomkinson AE. Interactions of the DNA ligase IV-XRCC4 complex with DNA ends and the DNA-dependent protein kinase Journal of Biological Chemistry. 275: 26196-26205. PMID 10854421 DOI: 10.1074/Jbc.M000491200  0.841
2000 Izumi T, Hazra TK, Boldogh I, Tomkinson AE, Park MS, Ikeda S, Mitra S. Requirement for human AP endonuclease 1 for repair of 3′-blocking damage at DNA single-strand breaks induced by reactive oxygen species Carcinogenesis. 21: 1329-1334. DOI: 10.1093/Carcin/21.7.1329  0.715
1999 Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene. 18: 7883-99. PMID 10630641 DOI: 10.1038/Sj.Onc.1203283  0.687
1999 Matsumoto Y, Kim K, Hurwitz J, Gary R, Levin DS, Tomkinson AE, Park MS. Reconstitution of proliferating cell nuclear antigen-dependent repair of apurinic/apyrimidinic sites with purified human proteins Journal of Biological Chemistry. 274: 33703-33708. PMID 10559261 DOI: 10.1074/Jbc.274.47.33703  0.692
1999 Mackey ZB, Niedergang C, Murcia JM, Leppard J, Au K, Chen J, de Murcia G, Tomkinson AE. DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III. The Journal of Biological Chemistry. 274: 21679-87. PMID 10419478 DOI: 10.1074/Jbc.274.31.21679  0.893
1999 Rodriguez K, Talamantez J, Huang W, Reed SH, Wang Z, Chen L, Feaver WJ, Friedberg EC, Tomkinson AE. Affinity purification and partial characterization of a yeast multiprotein complex for nucleotide excision repair using histidine-tagged Rad14 protein. The Journal of Biological Chemistry. 273: 34180-9. PMID 9852079 DOI: 10.1074/Jbc.273.51.34180  0.589
1999 Ramos W, Liu G, Giroux CN, Tomkinson AE. Biochemical and genetic characterization of the DNA ligase encoded by Saccharomyces cerevisiae open reading frame YOR005c, a homolog of mammalian DNA ligase IV. Nucleic Acids Research. 26: 5676-83. PMID 9837999 DOI: 10.1093/Nar/26.24.5676  0.671
1998 Huang W, Feaver WJ, Tomkinson AE, Friedberg EC. The N-degron protein degradation strategy for investigating the function of essential genes: requirement for replication protein A and proliferating cell nuclear antigen proteins for nucleotide excision repair in yeast extracts. Mutation Research. 408: 183-94. PMID 9806417 DOI: 10.1016/S0921-8777(98)00031-7  0.582
1998 Karimi-Busheri F, Lee J, Tomkinson AE, Weinfeld M. Repair of DNA strand gaps and nicks containing 3'-phosphate and 5'-hydroxyl termini by purified mammalian enzymes. Nucleic Acids Research. 26: 4395-400. PMID 9742240 DOI: 10.1093/Nar/26.19.4395  0.733
1998 Srivastava DK, Berg BJ, Prasad R, Molina JT, Beard WA, Tomkinson AE, Wilson SH. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. The Journal of Biological Chemistry. 273: 21203-9. PMID 9694877 DOI: 10.1074/Jbc.273.33.21203  0.757
1998 Dimitriadis EK, Prasad R, Vaske MK, Chen L, Tomkinson AE, Lewis MS, Wilson SH. Thermodynamics of human DNA ligase I trimerization and association with DNA polymerase beta. The Journal of Biological Chemistry. 273: 20540-50. PMID 9685411 DOI: 10.1074/Jbc.273.32.20540  0.631
1998 Montecucco A, Rossi R, Levin DS, Gary R, Park MS, Motycka TA, Ciarrocchi G, Villa A, Biamonti G, Tomkinson AE. DNA ligase I is recruited to sites of DNA replication by an interaction with proliferating cell nuclear antigen: identification of a common targeting mechanism for the assembly of replication factories. The Embo Journal. 17: 3786-95. PMID 9649448 DOI: 10.1093/Emboj/17.13.3786  0.863
1998 Tomkinson AE, Mackey ZB. Structure and function of mammalian DNA ligases. Mutation Research. 407: 1-9. PMID 9539976 DOI: 10.1016/S0921-8777(97)00050-5  0.913
1997 Kamel D, Mackey ZB, Sjöblom T, Walter CA, McCarrey JR, Uitto L, Palosaari H, Lähdetie J, Tomkinson AE, Syväoja JE. Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice. Biology of Reproduction. 57: 1367-74. PMID 9408242 DOI: 10.1095/Biolreprod57.6.1367  0.884
1997 Levin DS, Bai W, Yao N, O'Donnell M, Tomkinson AE. An interaction between DNA ligase I and proliferating cell nuclear antigen: implications for Okazaki fragment synthesis and joining. Proceedings of the National Academy of Sciences of the United States of America. 94: 12863-8. PMID 9371766 DOI: 10.1073/pnas.94.24.12863  0.825
1997 Tomkinson AE, Levin DS. Mammalian DNA ligases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 19: 893-901. PMID 9363683 DOI: 10.1002/Bies.950191009  0.855
1997 Du Q, Tomkinson AE, Gardner PD. Transcriptional regulation of neuronal nicotinic acetylcholine receptor genes. A possible role for the DNA-binding protein Puralpha. The Journal of Biological Chemistry. 272: 14990-5. PMID 9169473 DOI: 10.1074/Jbc.272.23.14990  0.473
1997 Ramos W, Tappe N, Talamantez J, Friedberg EC, Tomkinson AE. Two distinct DNA ligase activities in mitotic extracts of the yeast Saccharomyces cerevisiae. Nucleic Acids Research. 25: 1485-92. PMID 9092653 DOI: 10.1093/Nar/25.8.1485  0.821
1997 Mackey ZB, Ramos W, Levin DS, Walter CA, McCarrey JR, Tomkinson AE. An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination. Molecular and Cellular Biology. 17: 989-98. PMID 9001252 DOI: 10.1128/Mcb.17.2.989  0.876
1996 Tang CM, Tomkinson AE, Lane WS, Wold MS, Seto E. Replication protein A is a component of a complex that binds the human metallothionein IIA gene transcription start site. The Journal of Biological Chemistry. 271: 21637-44. PMID 8702952 DOI: 10.1074/Jbc.271.35.21637  0.39
1996 Rodriguez K, Wang Z, Friedberg EC, Tomkinson AE. Identification of functional domains within the RAD1·RAD10 repair and recombination endonuclease of Saccharomyces cerevisiae Journal of Biological Chemistry. 271: 20551-20558. PMID 8702799 DOI: 10.1074/Jbc.271.34.20551  0.706
1996 Prasad R, Singhal RK, Srivastava DK, Molina JT, Tomkinson AE, Wilson SH. Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. The Journal of Biological Chemistry. 271: 16000-7. PMID 8663274 DOI: 10.1074/Jbc.271.27.16000  0.576
1995 Friedberg EC, Bardwell AJ, Bardwell L, Feaver WJ, Kornberg RD, Svejstrup JQ, Tomkinson AE, Wang Z. Nucleotide excision repair in the yeast Saccharomyces cerevisiae: its relationship to specialized mitotic recombination and RNA polymerase II basal transcription Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 347: 63-68. PMID 7746856 DOI: 10.1098/Rstb.1995.0010  0.397
1995 Husain I, Tomkinson AE, Burkhart WA, Moyer MB, Ramos W, Mackey ZB, Besterman JM, Chen J. Purification and characterization of DNA ligase III from bovine testes. Homology with DNA ligase II and vaccinia DNA ligase. The Journal of Biological Chemistry. 270: 9683-90. PMID 7721901 DOI: 10.1074/Jbc.270.16.9683  0.889
1995 Chen J, Tomkinson AE, Ramos W, Mackey ZB, Danehower S, Walter CA, Schultz RA, Besterman JM, Husain I. Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Molecular and Cellular Biology. 15: 5412-22. PMID 7565692 DOI: 10.1128/Mcb.15.10.5412  0.891
1995 Davies AA, Friedberg EC, Tomkinson AE, Wood RD, West SC. Role of the Rad1 and Rad10 proteins in nucleotide excision repair and recombination. The Journal of Biological Chemistry. 270: 24638-41. PMID 7559571 DOI: 10.1074/Jbc.270.42.24638  0.762
1994 Tomkinson AE, Bardwell AJ, Tappe N, Ramos W, Friedberg EC. Purification of Rad1 protein from Saccharomyces cerevisiae and further characterization of the Rad1/Rad10 endonuclease complex. Biochemistry. 33: 5305-11. PMID 8172904 DOI: 10.1021/Bi00183A038  0.718
1994 Bardwell AJ, Bardwell L, Wang Z, Siede W, Reagan MS, Tomkinson AE, Friedberg AS, Pittenger C, Feaver WJ, Svejstrup J, Kornberg RD, Friedberg EC. Recent insights on DNA repair. The mechanism of damaged nucleotide excision in eukaryotes and its relationship to other cellular processes Annals of the New York Academy of Sciences. 726: 281-291. PMID 8092684 DOI: 10.1111/J.1749-6632.1994.Tb52829.X  0.754
1994 Bardwell AJ, Bardwell L, Tomkinson AE, Friedberg EC. Specific cleavage of model recombination and repair intermediates by the yeast Rad1-Rad10 DNA endonuclease Science. 265: 2082-2085. PMID 8091230 DOI: 10.1126/Science.8091230  0.755
1994 Wang YC, Burkhart WA, Mackey ZB, Moyer MB, Ramos W, Husain I, Chen J, Besterman JM, Tomkinson AE. Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation. The Journal of Biological Chemistry. 269: 31923-8. PMID 7989368  0.887
1993 Tomkinson AE, Starr R, Schultz RA. DNA ligase III is the major high molecular weight DNA joining activity in SV40-transformed human fibroblasts: Normal levels of DNA ligase III activity in bloom syndrome cells Nucleic Acids Research. 21: 5425-5430. PMID 8265359 DOI: 10.1093/Nar/21.23.5425  0.765
1992 Barnes DE, Tomkinson AE, Lehmann AR, Webster ADB, Lindahl T. Mutations in the DNA ligase I gene of an individual with immunodeficiencies and cellular hypersensitivity to DNA-damaging agents Cell. 69: 495-503. PMID 1581963 DOI: 10.1016/0092-8674(92)90450-Q  0.781
1992 Tomkinson AE, Tappe NJ, Friedberg EC. DNA ligase I from Saccharomyces cerevisiae: physical and biochemical characterization of the CDC9 gene product. Biochemistry. 31: 11762-71. PMID 1445910 DOI: 10.1021/Bi00162A013  0.801
1991 Tomkinson AE, Totty NF, Ginsburg M, Lindahl T. Location of the active site for enzyme-adenylate formation in DNA ligases. Proceedings of the National Academy of Sciences of the United States of America. 88: 400-4. PMID 1988940 DOI: 10.1073/pnas.88.2.400  0.598
1990 Tomkinson AE, Bonk RT, Kim J, Bartfeld N, Linn S. Mammalian mitochondrial endonuclease activities specific for ultraviolet-irradiated DNA. Nucleic Acids Research. 18: 929-35. PMID 2315045 DOI: 10.1093/Nar/18.4.929  0.406
1990 Lasko DD, Tomkinson AE, Lindahl T. Eukaryotic DNA ligases. Mutation Research. 236: 277-87. PMID 2204827 DOI: 10.1016/0921-8777(90)90011-S  0.714
1990 Barnes DE, Johnston LH, Kodama KI, Tomkinson AE, Lasko DD, Lindahl T. Human DNA ligase I cDNA: Cloning and functional expression in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 87: 6679-6683. PMID 2204063 DOI: 10.1073/pnas.87.17.6679  0.637
1986 Tomkinson AE, Linn S. Purification and properties of a single strand-specific endonuclease from mouse cell mitochondria. Nucleic Acids Research. 14: 9579-93. PMID 3027656 DOI: 10.1093/Nar/14.24.9579  0.599
1981 Hickson ID, Gordon RL, Tomkinson AE, Emmerson PT. A temperature sensitive RecA protein of Escherichia coli Mgg Molecular &Amp; General Genetics. 184: 68-72. PMID 6460915 DOI: 10.1007/BF00271197  0.494
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