☰

Chris Dealwis - Publications

Affiliations: 
The University of Tennessee, Knoxville, TN, United States 
Area:
Biochemistry
Tree Info Similar researchers PubMed Report error

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wan Q, Bennett BC, Wymore T, Li Z, Wilson MA, Brooks CL, Langan P, Kovalevsky A, Dealwis CG. Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid-Base Catalysis. Acs Catalysis. 11: 5873-5884. PMID 34055457 DOI: 10.1021/acscatal.1c00417  0.73
2016 Knappenberger AJ, Mohammed FA, Viswanathan R, Dealwis CG, Harris ME. Nucleoside analog triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity. Biochemistry. PMID 27634056 DOI: 10.1021/Acs.Biochem.6B00594  0.311
2014 Wan Q, Bennett BC, Wilson MA, Kovalevsky A, Langan P, Howell EE, Dealwis C. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 111: 18225-30. PMID 25453083 DOI: 10.1073/Pnas.1415856111  0.749
2014 Wan Q, Kovalevsky AY, Wilson MA, Bennett BC, Langan P, Dealwis C. Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+. Acta Crystallographica. Section F, Structural Biology Communications. 70: 814-8. PMID 24915100 DOI: 10.1107/S2053230X1400942X  0.732
2012 Ahmad MF, Wan Q, Jha S, Motea E, Berdis A, Dealwis C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Molecular Cancer Therapeutics. 11: 2077-86. PMID 22933704 DOI: 10.1158/1535-7163.Mct-12-0199  0.433
2011 Wan Q, Ahmad MF, Fairman J, Gorzelle B, de la Fuente M, Dealwis C, Maguire ME. X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB. Structure (London, England : 1993). 19: 700-10. PMID 21565704 DOI: 10.1016/J.Str.2011.02.011  0.388
2011 Miyagi M, Wan Q, Ahmad MF, Gokulrangan G, Tomechko SE, Bennett B, Dealwis C. Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Plos One. 6: e17055. PMID 21359214 DOI: 10.1371/Journal.Pone.0017055  0.719
2009 Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors. Chemmedchem. 4: 1649-56. PMID 19681093 DOI: 10.1002/Cmdc.200900236  0.404
2009 Gardberg A, Dice L, Pridgen K, Ko J, Patterson P, Ou S, Wetzel R, Dealwis C. Structures of Aβ-related peptide-monoclonal antibody complexes Biochemistry. 48: 5210-5217. PMID 19385664 DOI: 10.1021/Bi9001216  0.335
2009 Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. Journal of Structural Biology. 166: 162-71. PMID 19374017 DOI: 10.1016/J.Jsb.2009.01.001  0.752
2008 Xu H, Fairman JW, Wijerathna SR, Kreischer NR, LaMacchia J, Helmbrecht E, Cooperman BS, Dealwis C. The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore. Journal of Medicinal Chemistry. 51: 4653-9. PMID 18610997 DOI: 10.1021/Jm800350U  0.383
2008 Bennett BC, Gardberg AS, Blair MD, Dealwis CG. On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study. Acta Crystallographica. Section D, Biological Crystallography. 764-83. PMID 18566512 DOI: 10.1107/S0907444908012845  0.736
2008 Langan P, Fisher Z, Kovalevsky A, Mustyakimov M, Sutcliffe Valone A, Unkefer C, Waltman MJ, Coates L, Adams PD, Afonine PV, Bennett B, Dealwis C, Schoenborn BP. Protein structures by spallation neutron crystallography. Journal of Synchrotron Radiation. 15: 215-8. PMID 18421142 DOI: 10.1107/S0909049508000824  0.728
2007 Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C. Molecular basis for passive immunotherapy of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 15659-64. PMID 17895381 DOI: 10.1073/Pnas.0705888104  0.313
2007 Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG. Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase. Journal of Medicinal Chemistry. 50: 4374-81. PMID 17696333 DOI: 10.1021/Jm070319V  0.717
2006 Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proceedings of the National Academy of Sciences of the United States of America. 103: 18493-8. PMID 17130456 DOI: 10.1073/Pnas.0604977103  0.753
2006 Xu H, Faber C, Uchiki T, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proceedings of the National Academy of Sciences of the United States of America. 103: 4028-33. PMID 16537480 DOI: 10.1073/Pnas.0600440103  0.762
2006 Xu H, Faber C, Uchiki T, Fairman JW, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4022-7. PMID 16537479 DOI: 10.1073/Pnas.0600443103  0.774
2005 Bennett BC, Meilleur F, Myles DA, Howell EE, Dealwis CG. Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate. Acta Crystallographica. Section D, Biological Crystallography. 61: 574-9. PMID 15858267 DOI: 10.1107/S0907444905004804  0.735
2005 Sharp JS, Guo JT, Uchiki T, Xu Y, Dealwis C, Hettich RL. Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure. Analytical Biochemistry. 340: 201-12. PMID 15840492 DOI: 10.1016/J.Ab.2005.02.005  0.756
2004 Wall JS, Gupta V, Wilkerson M, Schell M, Loris R, Adams P, Solomon A, Stevens F, Dealwis C. Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins. Journal of Molecular Recognition : Jmr. 17: 323-31. PMID 15227639 DOI: 10.1002/Jmr.681  0.392
2004 Gupta V, Peterson CB, Dice LT, Uchiki T, Racca J, Guo JT, Xu Y, Hettich R, Zhao X, Rothstein R, Dealwis CG. Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p. Biochemistry. 43: 8568-78. PMID 15222768 DOI: 10.1021/Bi0361721  0.765
2004 Dealwis C, Wall J. Towards understanding the structure-function relationship of human amyloid disease. Current Drug Targets. 5: 159-71. PMID 15011949 DOI: 10.2174/1389450043490550  0.376
2004 Uchiki T, Dice LT, Hettich RL, Dealwis C. Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1. The Journal of Biological Chemistry. 279: 11293-303. PMID 14684746 DOI: 10.1074/Jbc.M309751200  0.739
2002 Uchiki T, Hettich R, Gupta V, Dealwis C. Characterization of monomeric and dimeric forms of recombinant Sml1p-histag protein by electrospray mass spectrometry. Analytical Biochemistry. 301: 35-48. PMID 11811965 DOI: 10.1006/Abio.2001.5492  0.759
1999 Sachpatzidis A, Dealwis C, Lubetsky JB, Liang PH, Anderson KS, Lolis E. Crystallographic studies of phosphonate-based alpha-reaction transition-state analogues complexed to tryptophan synthase. Biochemistry. 38: 12665-74. PMID 10504236 DOI: 10.1021/Bi9907734  0.337
1999 Lubetsky JB, Swope M, Dealwis C, Blake P, Lolis E. Pro-1 of macrophage migration inhibitory factor functions as a catalytic base in the phenylpyruvate tautomerase activity. Biochemistry. 38: 7346-54. PMID 10353846 DOI: 10.1021/Bi990306M  0.303
1995 Dealwis CG, Brennan C, Christianson K, Mandecki W, Abad-Zapatero C. Crystallographic analysis of reversible metal binding observed in a mutant (Asp153-->Gly) of Escherichia coli alkaline phosphatase. Biochemistry. 34: 13967-73. PMID 7577993 DOI: 10.1021/bi00043a001  0.336
1994 Dealwis CG, Frazao C, Badasso M, Cooper JB, Tickle IJ, Driessen H, Blundell TL, Murakami K, Miyazaki H, Sueiras-Diaz J. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen. Journal of Molecular Biology. 236: 342-60. PMID 8107115 DOI: 10.1006/jmbi.1994.1139  0.365
1993 Lisgarten JN, Gupta V, Maes D, Wyns L, Zegers I, Palmer RA, Dealwis CG, Aguilar CF, Hemmings AM. Structure of the crystalline complex of cytidylic acid (2'-CMP) with ribonuclease at 1.6 A resolution. Conservation of solvent sites in RNase-A high-resolution structures. Acta Crystallographica. Section D, Biological Crystallography. 49: 541-7. PMID 15299491 DOI: 10.1107/S090744499300719X  0.388
1993 Lunney EA, Hamilton HW, Hodges JC, Kaltenbronn JS, Repine JT, Badasso M, Cooper JB, Dealwis C, Wallace BA, Lowther WT. Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors. Journal of Medicinal Chemistry. 36: 3809-20. PMID 8254610  0.315
1992 Dhanaraj V, Dealwis CG, Frazao C, Badasso M, Sibanda BL, Tickle IJ, Cooper JB, Driessen HPC, Newman M, Aguilar C, Wood SP, Blundell TL, Hobart PM, Geoghegan KF, Ammirati MJ, et al. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins Nature. 357: 466-472. PMID 1608447 DOI: 10.1038/357466a0  0.336
Show low-probability matches.