Eric B. Kmiec - Publications

Affiliations: 
University of Delaware, Newark, DE, United States 
Area:
Molecular Biology, Biochemistry

162 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Sansbury BM, Hewes AM, Tharp OM, Masciarelli SB, Kaouser S, Kmiec EB. Homology directed correction, a new pathway model for point mutation repair catalyzed by CRISPR-Cas. Scientific Reports. 12: 8132. PMID 35581233 DOI: 10.1038/s41598-022-11808-2  0.434
2021 Kmiec EB, Bloh K. A toolmaker's perspective on CRISPR-directed gene editing as a therapeutic strategy for leukemia and beyond. Expert Review of Hematology. 1-6. PMID 34047246 DOI: 10.1080/17474086.2021.1935853  0.323
2021 Sansbury BM, Kmiec EB. On the Origins of Homology Directed Repair in Mammalian Cells. International Journal of Molecular Sciences. 22. PMID 33805897 DOI: 10.3390/ijms22073348  0.525
2021 Bloh K, Kanchana R, Bialk P, Banas K, Zhang Z, Yoo BC, Kmiec EB. Deconvolution of Complex DNA Repair (DECODR): Establishing a Novel Deconvolution Algorithm for Comprehensive Analysis of CRISPR-Edited Sanger Sequencing Data. The Crispr Journal. PMID 33571043 DOI: 10.1089/crispr.2020.0022  0.459
2020 Hewes AM, Sansbury BM, Kmiec EB. The Diversity of Genetic Outcomes from CRISPR/Cas Gene Editing is Regulated by the Length of the Symmetrical Donor DNA Template. Genes. 11. PMID 33008045 DOI: 10.3390/genes11101160  0.428
2020 Modarai SR, Kanda S, Bloh K, Opdenaker LM, Kmiec EB. Precise and error-prone CRISPR-directed gene editing activity in human CD34+ cells varies widely among patient samples. Gene Therapy. PMID 32873924 DOI: 10.1038/S41434-020-00192-Z  0.488
2020 Rivera-Torres N, Banas K, Kmiec EB. Modeling pediatric AML FLT3 mutations using CRISPR/Cas12a- mediated gene editing. Leukemia & Lymphoma. 1-11. PMID 32815753 DOI: 10.1080/10428194.2020.1805740  0.427
2020 Hewes AM, Sansbury BM, Barth S, Tarcic G, Kmiec EB. gRNA Sequence Heterology Tolerance Catalyzed by CRISPR/Cas in an In Vitro Homology-Directed Repair Reaction. Molecular Therapy. Nucleic Acids. 20: 568-579. PMID 32330873 DOI: 10.1016/J.Omtn.2020.03.012  0.581
2020 Banas K, Rivera-Torres N, Bialk P, Yoo BC, Kmiec EB. Kinetics of nuclear uptake and site-specific DNA cleavage during CRISPR-directed gene editing in solid tumor cells. Molecular Cancer Research : McR. PMID 32184217 DOI: 10.1158/1541-7786.Mcr-19-1208  0.511
2019 Sansbury BM, Hewes AM, Kmiec EB. Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repair. Communications Biology. 2: 458. PMID 31925273 DOI: 10.1038/s42003-019-0705-y  0.415
2019 Kmiec EB. Genome Editing Session: Trends and Core Functions for CRISPR-Directed Gene Editing. Journal of Biomolecular Techniques : Jbt. 30: S51-S52. PMID 31896996  0.357
2019 Sansbury BM, Hewes AM, Kmiec EB. Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repair. Communications Biology. 2: 458. PMID 31840103 DOI: 10.1038/s42003-019-0705-y  0.415
2019 Sansbury BM, Wagner AM, Tarcic G, Barth S, Nitzan E, Goldfus R, Vidne M, Kmiec EB. CRISPR-Directed Gene Editing Catalyzes Precise Gene Segment Replacement Enabling a Novel Method for Multiplex Site-Directed Mutagenesis. The Crispr Journal. 2: 121-132. PMID 30998096 DOI: 10.1089/crispr.2018.0054  0.538
2019 Tarcic G, Sansbury BM, Wagner AM, Barth S, Paniri E, Kmiec EB. A novel CRISPR-directed gene editing method that catalyzes precise gene segment replacement in vitro enabling multiplex site-directed mutagenesis. Journal of Clinical Oncology. 37: e14688-e14688. DOI: 10.1200/JCO.2019.37.15_SUPPL.E14688  0.442
2018 Sansbury BM, Wagner AM, Nitzan E, Tarcic G, Kmiec EB. CRISPR-Directed Gene Editing of Plasmid DNA Catalyzed by Cpf1 (Cas12a) Nuclease and a Mammalian Cell-Free Extract. The Crispr Journal. 1: 191-202. PMID 30687813 DOI: 10.1089/crispr.2018.0006  0.521
2018 Bialk P, Wang Y, Banas K, Kmiec EB. Functional Gene Knockout of Increases Chemosensitivity of Human Lung Cancer A549 Cells and in a Xenograft Mouse Model. Molecular Therapy Oncolytics. 11: 75-89. PMID 30505938 DOI: 10.1016/J.Omto.2018.10.002  0.458
2018 Modarai SR, Man D, Bialk P, Rivera-Torres N, Bloh K, Kmiec EB. Efficient Delivery and Nuclear Uptake Is Not Sufficient to Detect Gene Editing in CD34+ Cells Directed by a Ribonucleoprotein Complex. Molecular Therapy. Nucleic Acids. 11: 116-129. PMID 29858048 DOI: 10.1016/J.Omtn.2018.01.013  0.489
2017 Rivera-Torres N, Kmiec EB. A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells. Journal of Visualized Experiments : Jove. PMID 28872131 DOI: 10.3791/56195  0.563
2017 Bloh KM, Bialk PA, Gopalakrishnapillai A, Kolb EA, Kmiec EB. CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome. Molecular Therapy. Nucleic Acids. 7: 288-298. PMID 28624204 DOI: 10.1016/j.omtn.2017.04.009  0.356
2017 Woolf TM, Gurumurthy CB, Boyce F, Kmiec EB. To cleave or not to cleave: therapeutic gene editing with and without programmable nucleases. Nature Reviews. Drug Discovery. PMID 28303022 DOI: 10.1038/nrd.2017.42  0.404
2017 Rivera-Torres N, Banas K, Bialk P, Bloh KM, Kmiec EB. Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides. Plos One. 12: e0169350. PMID 28052104 DOI: 10.1371/Journal.Pone.0169350  0.67
2016 Bialk P, Sansbury B, Rivera-Torres N, Bloh K, Man D, Kmiec EB. Analyses of point mutation repair and allelic heterogeneity generated by CRISPR/Cas9 and single-stranded DNA oligonucleotides. Scientific Reports. 6: 32681. PMID 27609304 DOI: 10.1038/srep32681  0.569
2016 Rivera-Torres N, Kmiec EB. Genetic spell-checking: gene editing using single-stranded DNA oligonucleotides. Plant Biotechnology Journal. 14: 463-70. PMID 26402400 DOI: 10.1111/pbi.12473  0.497
2016 Man D, Sansbury B, Bialk P, Bloh K, Kolb EA, Kmiec EB. Target Site Mutagenesis during Crispr/ Cas 9/Single-Stranded- Oligonucleotide Directed Gene Editing for Sickle Cell Anemia Blood. 128: 4706-4706. DOI: 10.1182/Blood.V128.22.4706.4706  0.608
2015 Bialk P, Rivera-Torres N, Strouse B, Kmiec EB. Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems. Plos One. 10: e0129308. PMID 26053390 DOI: 10.1371/journal.pone.0129308  0.608
2015 Borjigin M, Kmiec EB, Wu R. A Highly Sensitive Assessment Tool for the Gene Editing Efficiency of Sickle Cell Disease Hemoglobin Beta Gene Blood. 126: 5557-5557. DOI: 10.1182/blood.v126.23.5557.5557  0.49
2014 Rivera-Torres N, Strouse B, Bialk P, Niamat RA, Kmiec EB. The position of DNA cleavage by TALENs and cell synchronization influences the frequency of gene editing directed by single-stranded oligonucleotides. Plos One. 9: e96483. PMID 24788536 DOI: 10.1371/journal.pone.0096483  0.613
2014 Strouse B, Bialk P, Niamat RA, Rivera-Torres N, Kmiec EB. Combinatorial gene editing in mammalian cells using ssODNs and TALENs. Scientific Reports. 4: 3791. PMID 24445749 DOI: 10.1038/srep03791  0.505
2012 Bonner M, Strouse B, Applegate M, Livingston P, Kmiec EB. DNA damage response pathway and replication fork stress during oligonucleotide directed gene editing. Molecular Therapy. Nucleic Acids. 1: e18. PMID 23343929 DOI: 10.1038/mtna.2012.9  0.848
2012 Borjigin M, Strouse B, Niamat RA, Bialk P, Eskridge C, Xie J, Kmiec EB. Proliferation of genetically modified human cells on electrospun nanofiber scaffolds. Molecular Therapy. Nucleic Acids. 1: e59. PMID 23212298 DOI: 10.1038/mtna.2012.51  0.448
2012 Livingston P, Strouse B, Perry H, Borjigin M, Bialk P, Kmiec EB. Oligonucleotide delivery by nucleofection does not rescue the reduced proliferation phenotype of gene-edited cells. Nucleic Acid Therapeutics. 22: 405-13. PMID 23072627 DOI: 10.1089/nat.2012.0374  0.547
2011 Illuzzi JL, Vickers CA, Kmiec EB. Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin. Journal of Molecular Neuroscience : Mn. 45: 256-68. PMID 21465263 DOI: 10.1007/s12031-011-9516-4  0.379
2011 Falgowski K, Falgowski C, York-Vickers C, Kmiec EB. Strand bias influences the mechanism of gene editing directed by single-stranded DNA oligonucleotides. Nucleic Acids Research. 39: 4783-94. PMID 21343181 DOI: 10.1093/Nar/Gkr061  0.849
2011 Falgowski KA, Kmiec EB. Gene editing activity on extrachromosomal arrays in C. elegans transgenics. Gene. 475: 87-93. PMID 21241788 DOI: 10.1016/J.Gene.2010.12.014  0.816
2009 Bonner M, Kmiec EB. DNA breakage associated with targeted gene alteration directed by DNA oligonucleotides. Mutation Research. 669: 85-94. PMID 19463835 DOI: 10.1016/J.Mrfmmm.2009.05.004  0.84
2009 Maguire K, Suzuki T, DiMatteo D, Parekh-Olmedo H, Kmiec E. Genetic correction of splice site mutation in purified and enriched myoblasts isolated from mdx5cv mice. Bmc Molecular Biology. 10: 15. PMID 19236710 DOI: 10.1186/1471-2199-10-15  0.817
2009 Engstrom JU, Suzuki T, Kmiec EB. Regulation of targeted gene repair by intrinsic cellular processes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 31: 159-68. PMID 19204988 DOI: 10.1002/Bies.200800119  0.877
2009 Grisolia AB, Curi RA, De Lima VF, Olmedo HP, Kmiec E, Nunes CM, Aoki SM, Garcia JF. Targeted nucleotide exchange in bovine myostatin gene. Animal Biotechnology. 20: 15-27. PMID 19160084 DOI: 10.1080/10495390802594693  0.44
2009 Illuzzi J, Yerkes S, Parekh-Olmedo H, Kmiec EB. DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates. Journal of Neuroscience Research. 87: 733-47. PMID 18831068 DOI: 10.1002/Jnr.21881  0.562
2008 Engstrom JU, Kmiec EB. DNA replication, cell cycle progression and the targeted gene repair reaction. Cell Cycle (Georgetown, Tex.). 7: 1402-14. PMID 18424915 DOI: 10.4161/Cc.7.10.5826  0.87
2008 Schwartz TR, Vasta CA, Bauer TL, Parekh-Olmedo H, Kmiec EB. G-rich oligonucleotides alter cell cycle progression and induce apoptosis specifically in OE19 esophageal tumor cells. Oligonucleotides. 18: 51-63. PMID 18321162 DOI: 10.1089/Oli.2007.0109  0.752
2008 DiMatteo D, Callahan S, Kmiec EB. Genetic conversion of an SMN2 gene to SMN1: a novel approach to the treatment of spinal muscular atrophy. Experimental Cell Research. 314: 878-86. PMID 18078930 DOI: 10.1016/J.Yexcr.2007.10.012  0.569
2007 Parekh-Olmedo H, Kmiec EB. Progress and prospects: targeted gene alteration (TGA). Gene Therapy. 14: 1675-80. PMID 17972921 DOI: 10.1038/Sj.Gt.3303053  0.534
2007 Ferrara L, Engstrom JU, Schwartz T, Parekh-Olmedo H, Kmiec EB. Recovery of cell cycle delay following targeted gene repair by oligonucleotides. Dna Repair. 6: 1529-35. PMID 17560837 DOI: 10.1016/J.Dnarep.2007.04.007  0.834
2007 Engstrom JU, Kmiec EB. Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair. Bmc Molecular Biology. 8: 9. PMID 17284323 DOI: 10.1186/1471-2199-8-9  0.848
2007 Schwartz TR, Kmiec EB. Reduction of gene repair by selenomethionine with the use of single-stranded oligonucleotides. Bmc Molecular Biology. 8: 7. PMID 17257432 DOI: 10.1186/1471-2199-8-7  0.857
2007 Maguire KK, Kmiec EB. Multiple roles for MSH2 in the repair of a deletion mutation directed by modified single-stranded oligonucleotides. Gene. 386: 107-14. PMID 17113727 DOI: 10.1016/J.Gene.2006.08.014  0.867
2007 Vasta CA, Schwartz TR, Bauer TL, Petrelli NJ, Kmiec EB. ssDNA Oligonucleotides Arrest Growth of Esophageal Cancer ells The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A288-C  0.708
2006 Skogen M, Roth J, Yerkes S, Parekh-Olmedo H, Kmiec E. Short G-rich oligonucleotides as a potential therapeutic for Huntington's Disease. Bmc Neuroscience. 7: 65. PMID 17014717 DOI: 10.1186/1471-2202-7-65  0.332
2006 Ferrara L, Kmiec EB. Targeted gene repair activates Chk1 and Chk2 and stalls replication in corrected cells. Dna Repair. 5: 422-31. PMID 16414312 DOI: 10.1016/J.Dnarep.2005.11.009  0.664
2006 Maguire K, Schwartz T, Kmiec E. 1036. Overcoming Suppression of Oligonucleotide-Directed Targeted Gene Repair in Mammalian Cells Molecular Therapy. 13: S397. DOI: 10.1016/J.Ymthe.2006.08.1131  0.845
2006 Skogen M, Roth J, Parekh-Olmedo H, Kmiec E. 1035. Short G-Rich Oligonucleotides as a Therapeutic for Huntingtonss Disease Molecular Therapy. 13: S397. DOI: 10.1016/J.Ymthe.2006.08.1130  0.332
2006 Ferrara L, Engstrom J, Kmiec E. 1026. Manipulation of S Phase Progression Can Counteract Cell Cycle Arrest of Corrected Cells during the Oligonucleotide-Directed Gene Repair Reaction Molecular Therapy. 13: S395. DOI: 10.1016/J.Ymthe.2006.08.1121  0.849
2006 Schwartz T, Kmiec E. ss DNA oligonucleotides increase sensitivity of cancer cells to chemotherapeutic agents Journal of Surgical Research. 130: 307-308. DOI: 10.1016/j.jss.2005.11.427  0.77
2005 Drury MD, Skogen MJ, Kmiec EB. A tolerance of DNA heterology in the mammalian targeted gene repair reaction. Oligonucleotides. 15: 155-71. PMID 16201904 DOI: 10.1089/Oli.2005.15.155  0.624
2005 Parekh-Olmedo H, Ferrara L, Brachman E, Kmiec EB. Gene therapy progress and prospects: targeted gene repair. Gene Therapy. 12: 639-46. PMID 15815682 DOI: 10.1038/Sj.Gt.3302511  0.829
2005 Hu Y, Parekh-Olmedo H, Drury M, Skogen M, Kmiec EB. Reaction parameters of targeted gene repair in mammalian cells. Molecular Biotechnology. 29: 197-210. PMID 15767697 DOI: 10.1385/Mb:29:3:197  0.665
2005 Brachman EE, Kmiec EB. Gene repair in mammalian cells is stimulated by the elongation of S phase and transient stalling of replication forks. Dna Repair. 4: 445-57. PMID 15725625 DOI: 10.1016/J.Dnarep.2004.11.007  0.877
2005 Engstrom J, Ferrara L, Parekh-Olmedo H, Kmiec EB. 1056. Suppression and Enhancement of Gene Repair by the Modulation of ATM Function in Mammalian Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.603  0.884
2005 Parekh-Olmedo H, Brachman E, Kmiec EB. 385. Gene Correction in the Absence of DNA Repair: A Universal Model Involving Homologous Pairing and DNA Replication Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.388  0.883
2005 Schwartz T, Ferrara L, Parekh-Olmedo H, Kmiec EB. 384. Double-Stranded DNA Breaks Stimulate the Frequency of Targeted Gene Repair in Mammalian Cells Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.387  0.869
2005 Maguire K, Parekh-Olmedo H, Kmiec EB. 380. Studies on the Mechanism of Gene Repair Using Saccharomyces cerevisae as a Model System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.383  0.852
2005 Ferrara L, Engstrom J, Brachman E, Drury M, Kmiec EB. 375. Targeted Gene Repair Induces the DNA Damage Response Pathways through the Activation of ATM, and the Stalling of Replication Forks Leading to a Blockage of Inherited Correction Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.378  0.863
2004 Drury MD, Kmiec EB. Double displacement loops (double d-loops) are templates for oligonucleotide-directed mutagenesis and gene repair. Oligonucleotides. 14: 274-86. PMID 15665595 DOI: 10.1089/Oli.2004.14.274  0.588
2004 Ferrara L, Kmiec EB. Camptothecin enhances the frequency of oligonucleotide-directed gene repair in mammalian cells by inducing DNA damage and activating homologous recombination. Nucleic Acids Research. 32: 5239-48. PMID 15466591 DOI: 10.1093/Nar/Gkh822  0.665
2004 Parekh-Olmedo H, Wang J, Gusella JF, Kmiec EB. Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine. Journal of Molecular Neuroscience : Mn. 24: 257-67. PMID 15456939 DOI: 10.1385/Jmn:24:2:257  0.399
2004 Ferrara L, Parekh-Olmedo H, Kmiec EB. Enhanced oligonucleotide-directed gene targeting in mammalian cells following treatment with DNA damaging agents. Experimental Cell Research. 300: 170-9. PMID 15383324 DOI: 10.1016/J.Yexcr.2004.06.021  0.687
2004 Brachman EE, Kmiec EB. DNA replication and transcription direct a DNA strand bias in the process of targeted gene repair in mammalian cells. Journal of Cell Science. 117: 3867-74. PMID 15265980 DOI: 10.1242/Jcs.01250  0.874
2004 Liu L, Maguire KK, Kmiec EB. Genetic re-engineering of Saccharomyces cerevisiae RAD51 leads to a significant increase in the frequency of gene repair in vivo. Nucleic Acids Research. 32: 2093-101. PMID 15087488 DOI: 10.1093/Nar/Gkh506  0.869
2004 van Brabant AJ, Williams JK, Parekh-Olmedo H, Kmiec EB. Gene editing of a human gene in yeast artificial chromosomes using modified single-stranded DNA and dual targeting. The Pharmacogenomics Journal. 4: 175-83. PMID 15007372 DOI: 10.1038/Sj.Tpj.6500237  0.529
2004 Maguire KK, Kmiec EB. Enhancement of in vivo targeted nucleotide exchange by nonspecific carrier DNA. Methods in Molecular Biology (Clifton, N.J.). 262: 209-19. PMID 14769964 DOI: 10.1385/1-59259-761-0:209  0.828
2004 Rice MC, Heckman BM, Liu Y, Kmiec EB. Fluorescent detection and isolation of DNA variants using stabilized RecA-coated oligonucleotides. Genome Research. 14: 116-25. PMID 14672976 DOI: 10.1101/Gr.1386204  0.458
2004 Kmiec EB, Ferrara L, Maguire K, Parekh-Olmedo H, Schwartz T. 317. DNA Damage and Homologous Recombination Regulate the Frequency and Process of Targeted Gene Repair Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.259  0.88
2004 Kmiec EB, Drury M. 315. Targeted Gene Repair Exhibits a Polar Bias in the Directionality of Correction Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.257  0.612
2004 Kmiec EB, Liu L, Parekh-Olmedo H. 310. Feasibility and Limitations of Target Gene Repair in Mammalian Cells Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.252  0.704
2004 Kmiec EB, Sonntag J, Brachman E. 305. Regulation of Targeted Gene Repair by DNA Replication and by DNA Replication Arrest Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.247  0.88
2003 Parekh-Olmedo H, Engstrom JU, Kmiec EB. The effect of hydroxyurea and trichostatin a on targeted nucleotide exchange in yeast and Mammalian cells. Annals of the New York Academy of Sciences. 1002: 43-55. PMID 14751821 DOI: 10.1196/Annals.1281.006  0.864
2003 Hu Y, Liu L, Kmiec EB. Reduction of Htt inclusion formation in strains of Saccharomyces cerevisiae deficient in certain DNA repair functions: a statistical analysis of phenotype. Experimental Cell Research. 291: 46-55. PMID 14597407 DOI: 10.1016/S0014-4827(03)00388-4  0.395
2003 Liu L, Usher M, Hu Y, Kmiec EB. Nuclease activity of Saccharomyces cerevisiae Mre11 functions in targeted nucleotide alteration. Applied and Environmental Microbiology. 69: 6216-24. PMID 14532083 DOI: 10.1128/Aem.69.10.6216-6224.2003  0.628
2003 Parekh-Olmedo H, Kmiec EB. Targeted nucleotide exchange in the CAG repeat region of the human HD gene. Biochemical and Biophysical Research Communications. 310: 660-6. PMID 14521962 DOI: 10.1016/J.Bbrc.2003.09.064  0.464
2003 Kmiec EB. Targeted gene repair -- in the arena. The Journal of Clinical Investigation. 112: 632-6. PMID 12952907 DOI: 10.1172/Jci19777  0.613
2003 Liu L, Parekh-Olmedo H, Kmiec EB. The development and regulation of gene repair. Nature Reviews. Genetics. 4: 679-89. PMID 12951569 DOI: 10.1038/Nrg1156  0.547
2003 Brachman EE, Kmiec EB. Targeted nucleotide repair of cyc1 mutations in Saccharomyces cerevisiae directed by modified single-stranded DNA oligonucleotides. Genetics. 163: 527-38. PMID 12618392  0.865
2003 Gamper HB, Nulf CJ, Corey DR, Kmiec EB. The synaptic complex of RecA protein participates in hybridization and inverse strand exchange reactions. Biochemistry. 42: 2643-55. PMID 12614159 DOI: 10.1021/Bi0205202  0.468
2003 Tran ND, Liu X, Yan Z, Abbote D, Jiang Q, Kmiec EB, Sigmund CD, Engelhardt JF. Efficiency of chimeraplast gene targeting by direct nuclear injection using a GFP recovery assay. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 248-53. PMID 12597913 DOI: 10.1016/S1525-0016(02)00039-4  0.621
2003 Drury MD, Kmiec EB. DNA pairing is an important step in the process of targeted nucleotide exchange. Nucleic Acids Research. 31: 899-910. PMID 12560486 DOI: 10.1093/Nar/Gkg171  0.685
2003 Agarwal S, Gamper HB, Kmiec EB. Nucleotide replacement at two sites can be directed by modified single-stranded oligonucleotides in vitro and in vivo. Biomolecular Engineering. 20: 7-20. PMID 12485680 DOI: 10.1016/S1389-0344(02)00088-6  0.517
2003 Kmiec EB, Liu L, Parekh-Olmedo H. Biased gene repair needs unbiased review Nature Reviews Genetics. 4: 752-752. DOI: 10.1038/Nrg1156-C2  0.501
2002 Parekh-Olmedo H, Drury M, Kmiec EB. Targeted nucleotide exchange in Saccharomyces cerevisiae directed by short oligonucleotides containing locked nucleic acids. Chemistry & Biology. 9: 1073-84. PMID 12401492 DOI: 10.1016/S1074-5521(02)00236-3  0.548
2002 Liu L, Cheng S, van Brabant AJ, Kmiec EB. Rad51p and Rad54p, but not Rad52p, elevate gene repair in Saccharomyces cerevisiae directed by modified single-stranded oligonucleotide vectors. Nucleic Acids Research. 30: 2742-50. PMID 12087156 DOI: 10.1093/Nar/Gkf397  0.639
2002 Brachman EE, Kmiec EB. The 'biased' evolution of targeted gene repair. Current Opinion in Molecular Therapeutics. 4: 171-6. PMID 12044039  0.854
2002 Liu L, Rice MC, Drury M, Cheng S, Gamper H, Kmiec EB. Strand bias in targeted gene repair is influenced by transcriptional activity. Molecular and Cellular Biology. 22: 3852-63. PMID 11997519 DOI: 10.1128/Mcb.22.11.3852-3863.2002  0.674
2002 Liu H, Agarwal S, Kmiec E, Davis BR. Targeted beta-globin gene conversion in human hematopoietic CD34(+ )and Lin(-)CD38(-)cells. Gene Therapy. 9: 118-26. PMID 11857070 DOI: 10.1038/Sj.Gt.3301610  0.398
2002 Parekh-Olmedo H, Krainc D, Kmiec EB. Targeted gene repair and its application to neurodegenerative disorders. Neuron. 33: 495-8. PMID 11856524 DOI: 10.1016/S0896-6273(02)00594-9  0.618
2001 Parekh-Olmedo H, Czymmek K, Kmiec EB. Targeted gene repair in mammalian cells using chimeric RNA/DNA oligonucleotides and modified single-stranded vectors. Science's Stke : Signal Transduction Knowledge Environment. 2001: pl1. PMID 11752645 DOI: 10.1126/Stke.2001.73.Pl1  0.634
2001 Liu L, Rice MC, Kmiec EB. In vivo gene repair of point and frameshift mutations directed by chimeric RNA/DNA oligonucleotides and modified single-stranded oligonucleotides. Nucleic Acids Research. 29: 4238-50. PMID 11600713 DOI: 10.1093/Nar/29.20.4238  0.675
2001 Kmiec EB, Johnson C, May GD. Chloroplast lysates support directed mutagenesis via modified DNA and chimeric RNA/DNA oligonucleotides. The Plant Journal : For Cell and Molecular Biology. 27: 267-74. PMID 11532172 DOI: 10.1046/J.1365-313X.2001.01083.X  0.599
2001 Kmiec EB, Ye S, Peng L. Targeted gene repair in mammalian cells using chimeric oligonucleotides. Genetic Engineering. 22: 23-31. PMID 11501379 DOI: 10.1007/978-1-4615-4199-8_3  0.523
2001 Rice MC, Bruner M, Czymmek K, Kmiec EB. In vitro and in vivo nucleotide exchange directed by chimeric RNA/DNA oligonucleotides in Saccharomyces cerevisae. Molecular Microbiology. 40: 857-68. PMID 11401693 DOI: 10.1046/J.1365-2958.2001.02407.X  0.653
2001 Rice MC, Czymmek K, Kmiec EB. The potential of nucleic acid repair in functional genomics. Nature Biotechnology. 19: 321-6. PMID 11283588 DOI: 10.1038/86701  0.497
2001 Gamper HB, Hou YM, Kmiec EB. Evidence for a four-strand exchange catalyzed by the RecA protein. Biochemistry. 39: 15272-81. PMID 11106508 DOI: 10.1021/Bi001704O  0.526
2000 Gamper HB, Parekh H, Rice MC, Bruner M, Youkey H, Kmiec EB. The DNA strand of chimeric RNA/DNA oligonucleotides can direct gene repair/conversion activity in mammalian and plant cell-free extracts. Nucleic Acids Research. 28: 4332-9. PMID 11058133 DOI: 10.1093/Nar/28.21.4332  0.55
2000 Rice MC, May GD, Kipp PB, Parekh H, Kmiec EB. Genetic repair of mutations in plant cell-free extracts directed by specific chimeric oligonucleotides. Plant Physiology. 123: 427-38. PMID 10859173 DOI: 10.1104/Pp.123.2.427  0.604
2000 Gamper HB, Cole-Strauss A, Metz R, Parekh H, Kumar R, Kmiec EB. A plausible mechanism for gene correction by chimeric oligonucleotides. Biochemistry. 39: 5808-16. PMID 10801331 DOI: 10.1021/Bi9921891  0.644
2000 Havre PA, Rice M, Ramos R, Kmiec EB. HsRec2/Rad51L1, a protein influencing cell cycle progression, has protein kinase activity. Experimental Cell Research. 254: 33-44. PMID 10623463 DOI: 10.1006/Excr.1999.4725  0.404
1999 Shu Z, Smith S, Wang L, Rice MC, Kmiec EB. Disruption of muREC2/RAD51L1 in mice results in early embryonic lethality which can Be partially rescued in a p53(-/-) background. Molecular and Cellular Biology. 19: 8686-93. PMID 10567591 DOI: 10.1128/Mcb.19.12.8686  0.37
1999 Kmiec EB. Synthetic gene carriers: the future looks bright. Structure and Design of Synthetic Gene Carriers. San Francisco, CA, USA, 24-26 February 1999. Molecular Medicine Today. 5: 241. PMID 10475709 DOI: 10.1016/S1357-4310(99)01489-6  0.37
1999 Kmiec EB. Targeted gene repair. Gene Therapy. 6: 1-3. PMID 10341868 DOI: 10.1038/Sj.Gt.3300789  0.558
1999 Cole-Strauss A, Gamper H, Holloman WK, Muñoz M, Cheng N, Kmiec EB. Targeted gene repair directed by the chimeric RNA/DNA oligonucleotide in a mammalian cell-free extract. Nucleic Acids Research. 27: 1323-30. PMID 9973621 DOI: 10.1093/Nar/27.5.1323  0.645
1999 Kmiec EB, Kren BT, Steer CJ. 23 Targeted Gene Repair in Mammalian Cells Using Chimeric RNA/DNA Oligonucleotides Cold Spring Harbor Monograph Archive. 36: 643-670. DOI: 10.1101/087969528.36.643  0.598
1998 Peng L, Rice MC, Kmiec EB. Analysis of the human RAD51L1 promoter region and its activation by UV light. Genomics. 54: 529-41. PMID 9878257 DOI: 10.1006/Geno.1998.5536  0.438
1998 Ye S, Cole-Strauss AC, Frank B, Kmiec EB. Targeted gene correction: a new strategy for molecular medicine. Molecular Medicine Today. 4: 431-7. PMID 9793931 DOI: 10.1016/S1357-4310(98)01344-6  0.544
1998 Thiyagarajan MM, Waldman SA, Noè M, Kmiec EB. Binding characteristics of Ustilago maydis topoisomerase I to DNA containing secondary structures. European Journal of Biochemistry. 255: 347-55. PMID 9716375 DOI: 10.1046/J.1432-1327.1998.2550347.X  0.421
1998 Havre PA, Kmiec EB. RecA-mediated joint molecule formation between O-methylated RNA/DNA hairpins and single-stranded targets. Molecular & General Genetics : Mgg. 258: 580-6. PMID 9671026 DOI: 10.1007/s004380050771  0.353
1998 Xiang Y, Cole-Strauss A, Yoon K, Gryn J, Kmiec EB. Targeted gene conversion in a mammalian CD34+-enriched cell population using a chimeric RNA/DNA oligonucleotide. Journal of Molecular Medicine (Berlin, Germany). 75: 829-35. PMID 9428613 DOI: 10.1007/S001090050172  0.552
1997 Fan G, Ma X, Kren BT, Rice M, Kmiec EB, Steer CJ. A novel link between REC2, a DNA recombinase, the retinoblastoma protein, and apoptosis. The Journal of Biological Chemistry. 272: 19413-7. PMID 9235941 DOI: 10.1074/Jbc.272.31.19413  0.472
1997 Dutta S, Gerhold DL, Rice M, Germann M, Kmiec EB. The cloning and overexpression of a cruciform binding protein from Ustilago maydis. Biochimica Et Biophysica Acta. 1352: 258-66. PMID 9224950 DOI: 10.1016/S0167-4781(96)00227-8  0.415
1997 Cole-Strauss A, Nöe A, Kmiec EB. Recombinational repair of genetic mutations. Antisense & Nucleic Acid Drug Development. 7: 211-6. PMID 9212913 DOI: 10.1089/Oli.1.1997.7.211  0.382
1997 Rice MC, Smith ST, Bullrich F, Havre P, Kmiec EB. Isolation of human and mouse genes based on homology to REC2, a recombinational repair gene from the fungus Ustilago maydis. Proceedings of the National Academy of Sciences of the United States of America. 94: 7417-22. PMID 9207106 DOI: 10.1073/Pnas.94.14.7417  0.461
1997 Kren BT, Cole-Strauss A, Kmiec EB, Steer CJ. Targeted nucleotide exchange in the alkaline phosphatase gene of HuH-7 cells mediated by a chimeric RNA/DNA oligonucleotide. Hepatology (Baltimore, Md.). 25: 1462-8. PMID 9185769 DOI: 10.1002/Hep.510250626  0.6
1997 Jiang W, Gerhold D, Kmiec EB, Hauser M, Becker JM, Koltin Y. The topoisomerase I gene from Candida albicans. Microbiology (Reading, England). 377-86. PMID 9043115 DOI: 10.1099/00221287-143-2-377  0.451
1996 Cole-Strauss A, Yoon K, Xiang Y, Byrne BC, Rice MC, Gryn J, Holloman WK, Kmiec EB. Correction of the mutation responsible for sickle cell anemia by an RNA-DNA oligonucleotide. Science (New York, N.Y.). 273: 1386-9. PMID 8703073 DOI: 10.1126/Science.273.5280.1386  0.469
1996 Yoon K, Cole-Strauss A, Kmiec EB. Targeted gene correction of episomal DNA in mammalian cells mediated by a chimeric RNA.DNA oligonucleotide. Proceedings of the National Academy of Sciences of the United States of America. 93: 2071-6. PMID 8700887 DOI: 10.1073/Pnas.93.5.2071  0.602
1996 Kotani H, Germann MW, Andrus A, Vinayak R, Mullah B, Kmiec EB. RNA facilitates RecA-mediated DNA pairing and strand transfer between molecules bearing limited regions of homology Molecular and General Genetics. 250: 626-634. PMID 8676865 DOI: 10.1007/Bf02174450  0.456
1995 Dutta S, Gerhold D, Kmiec EB. Assembly of nucleosomal DNA in a cell-free extract from wild-type and top1- strains of Ustilago maydis. Molecular & General Genetics : Mgg. 248: 675-85. PMID 7476870 DOI: 10.1007/Bf02191707  0.367
1995 Kmiec EB. Genetic manipulation in mammalian cells using an RNA/DNA chimeric oligonucleotide Advanced Drug Delivery Reviews. 17: 333-340. DOI: 10.1016/0169-409X(95)00068-I  0.636
1994 Cole AD, Kmiec EB. ATP-independent DNA renaturation catalyzed by a protein from Ustilago maydis. European Journal of Biochemistry / Febs. 220: 75-82. PMID 8119300 DOI: 10.1111/J.1432-1033.1994.Tb18600.X  0.465
1994 Kotani H, Kmiec EB. Transcription activates RecA-promoted homologous pairing of nucleosomal DNA. Molecular and Cellular Biology. 14: 1949-55. PMID 8114726 DOI: 10.1128/Mcb.14.3.1949  0.478
1994 Kmiec EB, Holloman WK. ATP-dependent DNA renaturation and DNA-dependent ATPase reactions catalyzed by the Ustilago maydis homologous pairing protein. European Journal of Biochemistry. 219: 865-75. PMID 8112338 DOI: 10.1111/J.1432-1033.1994.Tb18568.X  0.417
1994 Kotani H, Sekiguchi JM, Dutta S, Kmiec EB. Genetic recombination of nucleosomal templates is mediated by transcription. Molecular & General Genetics : Mgg. 244: 410-9. PMID 8078467 DOI: 10.1007/Bf00286693  0.474
1994 Kotani H, Kmiec EB. DNA cruciforms facilitate in vitro strand transfer on nucleosomal templates. Molecular & General Genetics : Mgg. 243: 681-90. PMID 8028585 DOI: 10.1007/Bf00279578  0.484
1994 Gerhold D, Thiyagarajan M, Kmiec EB. The topoisomerase I gene from Ustilago maydis: sequence, disruption and mutant phenotype. Nucleic Acids Research. 22: 3773-8. PMID 7937091 DOI: 10.1093/Nar/22.18.3773  0.534
1994 Kmiec EB, Cole A, Holloman WK. The REC2 gene encodes the homologous pairing protein of Ustilago maydis. Molecular and Cellular Biology. 14: 7163-72. PMID 7935431 DOI: 10.1128/Mcb.14.11.7163  0.511
1994 Kotani H, Kmiec EB. A role for RNA synthesis in homologous pairing events. Molecular and Cellular Biology. 14: 6097-106. PMID 7520527 DOI: 10.1128/Mcb.14.9.6097  0.42
1993 Nguyen TP, Kmiec EB. In vitro transcription of the c-myc first exon may be influenced by the extent of chromatin assembly. Molecular and Cellular Biochemistry. 120: 33-41. PMID 8459802 DOI: 10.1007/Bf00925982  0.371
1993 Ye S, Kmiec EB. The glucocorticoid receptor precludes the binding of a transcriptional repressor protein to the long terminal repeat of the mouse mammary tumor virus. Molecular and Cellular Biochemistry. 122: 25-37. PMID 8394505 DOI: 10.1007/Bf00925734  0.428
1993 Myers R, Kmiec EB. Characterization of Ustilago maydis DNA binding protein one (UBP1). Biochimica Et Biophysica Acta. 1174: 31-42. PMID 8392872 DOI: 10.1016/0167-4781(93)90089-V  0.467
1993 Thiyagarajan MM, Kotani H, Holloman WK, Kmiec EB. DNA relaxation mediated by Ustilago maydis type I topoisomerase; modulation by chromatin associated proteins. Biochimica Et Biophysica Acta. 1173: 155-64. PMID 8389206 DOI: 10.1016/0167-4781(93)90176-E  0.469
1993 Ye S, Kmiec EB. Positive regulation of tRNA gene expression by the mouse mammary tumor virus-long terminal repeat in vitro. Nucleic Acids Research. 21: 1307-14. PMID 8385315 DOI: 10.1093/Nar/21.5.1307  0.511
1993 Kotani H, Kmiec EB, Holloman WK. Purification and properties of a cruciform DNA binding protein from Ustilago maydis. Chromosoma. 102: 348-54. PMID 8325166 DOI: 10.1007/Bf00661278  0.379
1993 Hsu TC, Melchiorre LP, Maksymowych AB, Kmiec E, Litwack G. Assembly of glucocorticoid receptor and c-JUN homodimer on the promoter of mouse mammary tumor virus-long terminal repeat is influenced by order of addition. Biochemical and Biophysical Research Communications. 197: 1260-6. PMID 8280142 DOI: 10.1006/Bbrc.1993.2613  0.354
1992 Sekiguchi JM, Kmiec EB. In vitro chromatin assembly promoted by the Xenopus laevis S-150 cell-free extract is enhanced by treatment with RNase A. Nucleic Acids Research. 20: 889-95. PMID 1371870 DOI: 10.1093/Nar/20.4.889  0.38
1992 Cole AD, Heath-Pagliuso S, Baich A, Kmiec EB. In vitro analysis of a type I DNA topoisomerase activity from cultured tobacco cells. Plant Molecular Biology. 19: 265-76. PMID 1320423 DOI: 10.1007/Bf00027348  0.451
1991 Sekiguchi JM, Kmiec EB. An analysis of transcription factor TFIIIA-mediated DNA supercoiling. Dna and Cell Biology. 10: 223-32. PMID 2012680 DOI: 10.1089/Dna.1991.10.223  0.472
1991 Li HL, Kmiec EB. A glucocorticoid response element enhances transcription of a methionine tRNA gene in cis and trans. Molecular Endocrinology (Baltimore, Md.). 4: 1173-82. PMID 1963472 DOI: 10.1210/mend-4-8-1173  0.34
1990 Heath-Pagliuso S, Cole AD, Kmiec EB. Purification and characterization of a type-I topoisomerase from cultured tobacco cells. Plant Physiology. 94: 599-606. PMID 16667754 DOI: 10.1104/Pp.94.2.599  0.407
1990 Sekiguchi JM, Kmiec EB. DNA superhelicity enhances the assembly of transcriptionally active chromatin in vitro. Molecular & General Genetics : Mgg. 220: 73-80. PMID 2558288 DOI: 10.1007/BF00260859  0.329
1990 Sekiguchi JA, Kmiec EB. cis-acting enhancement of RNA polymerase III gene expression in vitro. Molecular & General Genetics : Mgg. 221: 435-42. PMID 2381423 DOI: 10.1007/BF00259409  0.373
1990 Sekiguchi JA, Kmiec EB. Reaction parameters of TFIIIA-induced supercoiling catalyzed by a Xenopus laevis cell-free extract. Nucleic Acids Research. 18: 1021-9. PMID 2315014 DOI: 10.1093/Nar/18.4.1021  0.525
1990 Sekiguchi JA, Cole AD, Gardner KH, Kmiec EB. Transcription factor TFIIIA stimulates DNA supercoiling promoted by a fractionated cell-free extract from Xenopus laevis. European Journal of Biochemistry / Febs. 192: 311-20. PMID 2209588 DOI: 10.1111/J.1432-1033.1990.Tb19229.X  0.398
1989 Sekiguchi JA, Kmiec EB. Studies on DNA topoisomerase activity during in vitro chromatin assembly. Molecular and Cellular Biochemistry. 83: 195-205. PMID 2849054 DOI: 10.1007/BF00226147  0.339
1989 Sekiguchi JM, Swank RA, Kmiec EB. Changes in DNA topology can modulate in vitro transcription of certain RNA polymerase III genes. Molecular and Cellular Biochemistry. 85: 123-33. PMID 2542762 DOI: 10.1007/BF00577108  0.504
1988 Kmiec EB. Transcription factor IIIA and 5S DNA supercoiling in vitro: toward a purified system. Cell. 54: 919-20. PMID 3416357 DOI: 10.1016/0092-8674(88)90104-3  0.424
1986 Kmiec EB, Holloman WK. Homologous pairing of DNA molecules by Ustilago rec1 protein is promoted by sequences of Z-DNA. Cell. 44: 545-54. PMID 3948243 DOI: 10.1016/0092-8674(86)90264-3  0.469
1986 Kmiec EB, Worcel A. The positive transcription factor of the 5S RNA gene proteolyses during direct exchange between 5S DNA sites. The Journal of Cell Biology. 103: 673-81. PMID 3745266 DOI: 10.1083/jcb.103.3.673  0.374
1986 Kmiec EB, Razvi F, Worcel A. The role of DNA-mediated transfer of TFIIIA in the concerted gyration and differential activation of the Xenopus 5S RNA genes. Cell. 45: 209-18. PMID 3698098 DOI: 10.1016/0092-8674(86)90385-5  0.541
1985 Kmiec EB, Angelides KJ, Holloman WK. Left-handed DNA and the synaptic pairing reaction promoted by Ustilago rec1 protein. Cell. 40: 139-45. PMID 3967291 DOI: 10.1016/0092-8674(85)90317-4  0.461
1985 Kmiec EB, Worcel A. The positive transcription factor of the 5S RNA gene induces a 5S DNA-specific gyration in Xenopus oocyte extracts. Cell. 41: 945-53. PMID 2408763 DOI: 10.1016/S0092-8674(85)80075-1  0.515
1984 Kmiec EB, Holloman WK. Synapsis promoted by Ustilago rec1 protein. Cell. 36: 593-8. PMID 6321036 DOI: 10.1016/0092-8674(84)90338-6  0.484
1983 Kmiec EB, Holloman WK. Heteroduplex formation and polarity during strand transfer promoted by Ustilago rec 1 protein. Cell. 33: 857-64. PMID 6871997 DOI: 10.1016/0092-8674(83)90028-4  0.427
1983 Kmiec EB, Kroeger PE, Brougham MJ, Holloman WK. Topological linkage of circular DNA molecules promoted by Ustilago rec 1 protein and topoisomerase. Cell. 34: 919-29. PMID 6313215 DOI: 10.1016/0092-8674(83)90549-4  0.477
1982 Kmiec E, Holloman WK. Homologous pairing of DNA molecules promoted by a protein from Ustilago. Cell. 29: 367-74. PMID 6214313 DOI: 10.1016/0092-8674(82)90153-2  0.547
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