| Year |
Citation |
Score |
| 2023 |
Ye C, Clements SA, Gu W, Geurts AM, Mathews CE, Serreze DV, Chen YG, Driver JP. Deletion of Vβ3CD4 T cells by endogenous mouse mammary tumor virus 3 prevents type 1 diabetes induction by autoreactive CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America. 120: e2312039120. PMID 38015847 DOI: 10.1073/pnas.2312039120 |
0.459 |
|
| 2023 |
Thirawatananond P, Brown ME, Sachs LK, Arnoletti JM, Yeh WI, Posgai AL, Shapiro MR, Chen YG, Brusko TM. Treg-specific CD226 Deletion Reduces Diabetes Incidence in NOD Mice by Improving Regulatory T Cell Stability. Diabetes. PMID 37625150 DOI: 10.2337/db23-0307 |
0.425 |
|
| 2023 |
Ciecko AE, Wang Y, Harleston S, Drewek A, Serreze DV, Geurts AM, Lin CW, Chen YG. Heterogeneity of Islet-Infiltrating IL-21+ CD4 T Cells in a Mouse Model of Type 1 Diabetes. Journal of Immunology (Baltimore, Md. : 1950). PMID 36762954 DOI: 10.4049/jimmunol.2200712 |
0.34 |
|
| 2022 |
Blum SI, Taylor JP, Barra JM, Burg AR, Shang Q, Qiu S, Shechter O, Hayes AR, Green TJ, Geurts AM, Chen YG, Tse HM. MDA5-dependent responses contribute to autoimmune diabetes progression and hindrance. Jci Insight. PMID 36512407 DOI: 10.1172/jci.insight.157929 |
0.424 |
|
| 2022 |
Rojas M, Heuer LS, Zhang W, Chen YG, Ridgway WM. The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes. Frontiers in Immunology. 13: 918837. PMID 35935980 DOI: 10.3389/fimmu.2022.918837 |
0.394 |
|
| 2022 |
Kasmani MY, Ciecko AE, Brown AK, Petrova G, Gorski J, Chen YG, Cui W. Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usage. Life Science Alliance. 5. PMID 35667687 DOI: 10.26508/lsa.202201503 |
0.44 |
|
| 2021 |
Ciecko AE, Schauder DM, Foda B, Petrova G, Kasmani MY, Burns R, Lin CW, Drobyski WR, Cui W, Chen YG. Self-Renewing Islet TCF1 CD8 T Cells Undergo IL-27-Controlled Differentiation to Become TCF1 Terminal Effectors during the Progression of Type 1 Diabetes. Journal of Immunology (Baltimore, Md. : 1950). PMID 34507949 DOI: 10.4049/jimmunol.2100362 |
0.424 |
|
| 2021 |
Allred MG, Chimenti MS, Ciecko AE, Chen YG, Lieberman SM. Characterization of Type I Interferon-Associated Chemokines and Cytokines in Lacrimal Glands of Nonobese Diabetic Mice. International Journal of Molecular Sciences. 22. PMID 33916486 DOI: 10.3390/ijms22073767 |
0.357 |
|
| 2021 |
Khatun A, Kasmani MY, Zander R, Schauder DM, Snook JP, Shen J, Wu X, Burns R, Chen YG, Lin CW, Williams MA, Cui W. Single-cell lineage mapping of a diverse virus-specific naive CD4 T cell repertoire. The Journal of Experimental Medicine. 218. PMID 33201171 DOI: 10.1084/jem.20200650 |
0.327 |
|
| 2020 |
Debreceni IL, Chimenti MS, Serreze DV, Geurts AM, Chen YG, Lieberman SM. Toll-Like Receptor 7 Is Required for Lacrimal Gland Autoimmunity and Type 1 Diabetes Development in Male Nonobese Diabetic Mice. International Journal of Molecular Sciences. 21. PMID 33322152 DOI: 10.3390/ijms21249478 |
0.317 |
|
| 2020 |
Shapiro MR, Yeh WI, Longfield JR, Gallagher J, Infante CM, Wellford S, Posgai AL, Atkinson MA, Campbell-Thompson M, Lieberman SM, Serreze DV, Geurts AM, Chen YG, Brusko TM. CD226 Deletion Reduces Type 1 Diabetes in the NOD Mouse by Impairing Thymocyte Development and Peripheral T Cell Activation. Frontiers in Immunology. 11: 2180. PMID 33013915 DOI: 10.3389/Fimmu.2020.02180 |
0.517 |
|
| 2020 |
Chen YG, Ciecko AE, Khaja S, Grzybowski M, Geurts AM, Lieberman SM. UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Scientific Reports. 10: 12019. PMID 32694640 DOI: 10.1038/S41598-020-68956-6 |
0.489 |
|
| 2020 |
Foda BM, Ciecko AE, Serreze DV, Ridgway WM, Geurts AM, Chen YG. The CD137 Ligand Is Important for Type 1 Diabetes Development but Dispensable for the Homeostasis of Disease-Suppressive CD137 FOXP3 Regulatory CD4 T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 32295876 DOI: 10.4049/Jimmunol.1900485 |
0.47 |
|
| 2020 |
Lee H, Lee YS, Harenda Q, Pietrzak S, Oktay HZ, Schreiber S, Liao Y, Sonthalia S, Ciecko AE, Chen YG, Keles S, Sridharan R, Engin F. Beta Cell Dedifferentiation Induced by IRE1α Deletion Prevents Type 1 Diabetes. Cell Metabolism. PMID 32220307 DOI: 10.1016/J.Cmet.2020.03.002 |
0.453 |
|
| 2019 |
Ciecko AE, Foda B, Barr JY, Ramanathan S, Atkinson MA, Serreze DV, Geurts AM, Lieberman SM, Chen YG. Interleukin-27 Is Essential for Type 1 Diabetes Development and Sjögren Syndrome-like Inflammation. Cell Reports. 29: 3073-3086.e5. PMID 31801074 DOI: 10.1016/J.Celrep.2019.11.010 |
0.43 |
|
| 2019 |
Itoh A, Ortiz L, Kachapati K, Wu Y, Adams D, Bednar K, Mukherjee S, Chougnet C, Mittler RS, Chen YG, Dolan L, Ridgway WM. Soluble CD137 Ameliorates Acute Type 1 Diabetes by Inducing T Cell Anergy. Frontiers in Immunology. 10: 2566. PMID 31787971 DOI: 10.3389/Fimmu.2019.02566 |
0.539 |
|
| 2019 |
Gioia L, Holt M, Costanzo A, Sharma S, Abe B, Kain L, Nakayama M, Wan X, Su A, Mathews C, Chen YG, Unanue E, Teyton L. Position β57 of I-A controls early anti-insulin responses in NOD mice, linking an MHC susceptibility allele to type 1 diabetes onset. Science Immunology. 4. PMID 31471352 DOI: 10.1126/Sciimmunol.Aaw6329 |
0.491 |
|
| 2019 |
Forsberg MH, Foda B, Serreze DV, Chen YG. Combined congenic mapping and nuclease-based gene targeting for studying allele-specific effects of Tnfrsf9 within the Idd9.3 autoimmune diabetes locus. Scientific Reports. 9: 4316. PMID 30867509 DOI: 10.1038/S41598-019-40898-8 |
0.479 |
|
| 2019 |
Sandor AM, Lindsay RS, Dyjack N, Whitesell JC, Rios C, Bradley BJ, Haskins K, Serreze DV, Geurts AM, Chen YG, Seibold MA, Jacobelli J, Friedman RS. CD11c Cells Are Gatekeepers for Lymphocyte Trafficking to Infiltrated Islets During Type 1 Diabetes. Frontiers in Immunology. 10: 99. PMID 30766536 DOI: 10.3389/Fimmu.2019.00099 |
0.477 |
|
| 2019 |
Young A, Nguyen V, Kang JH, Mehdizadeh S, Mei A, Sheehan KCF, Serreze DV, Chen Y, Schreiber RD, Bluestone JA. Abstract PR07: Developing syngeneic NOD tumor models to profile immunotoxicity and antitumor immunity in response to cancer immunotherapies in autoimmune-prone mice Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Pr07 |
0.351 |
|
| 2018 |
Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ, Chen YG, Hessner MJ. Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. Diabetologia. PMID 30167736 DOI: 10.1007/S00125-018-4708-X |
0.353 |
|
| 2018 |
Presa M, Racine JJ, Dwyer JR, Lamont DJ, Ratiu JJ, Sarsani VK, Chen YG, Geurts A, Schmitz I, Stearns T, Allocco J, Chapman HD, Serreze DV. A Hypermorphic Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8 T Cells in NOD Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 30127089 DOI: 10.4049/Jimmunol.1800465 |
0.525 |
|
| 2018 |
Chen YG, Mathews CE, Driver JP. The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future. Frontiers in Endocrinology. 9: 51. PMID 29527189 DOI: 10.3389/Fendo.2018.00051 |
0.456 |
|
| 2018 |
Racine JJ, Stewart I, Ratiu J, Christianson G, Lowell E, Helm K, Allocco J, Maser RS, Chen YG, Lutz CM, Roopenian D, Schloss J, DiLorenzo TP, Serreze DV. Improved Murine-MHC-Deficient HLA-Transgenic NOD-Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. PMID 29472249 DOI: 10.2337/Db17-1467 |
0.402 |
|
| 2018 |
Henschel AM, Cabrera SM, Kaldunski ML, Jia S, Geoffrey R, Roethle MF, Lam V, Chen YG, Wang X, Salzman NH, Hessner MJ. Modulation of the diet and gastrointestinal microbiota normalizes systemic inflammation and β-cell chemokine expression associated with autoimmune diabetes susceptibility. Plos One. 13: e0190351. PMID 29293587 DOI: 10.1371/Journal.Pone.0190351 |
0.408 |
|
| 2018 |
FODA B, FORSBERG MH, CIECKO AE, MUELLER KW, GEURTS A, CHEN Y. Investigating the Role of CD137 Ligand in the Pathogenesis of Type 1 Diabetes Diabetes. 67: 317-OR. DOI: 10.2337/Db18-317-Or |
0.496 |
|
| 2017 |
Forsberg MH, Ciecko AE, Bednar KJ, Itoh A, Kachapati K, Ridgway WM, Chen YG. CD137 Plays Both Pathogenic and Protective Roles in Type 1 Diabetes Development in NOD Mice. Journal of Immunology (Baltimore, Md. : 1950). PMID 28363905 DOI: 10.4049/Jimmunol.1601851 |
0.466 |
|
| 2016 |
Driver JP, Racine JJ, Ye C, Lamont DJ, Newby BN, McPhee-Leeth CG, Chapman HD, Brusko TM, Chen YG, Mathews CE, Serreze DV. Interferon gamma Limits Diabetogenic CD8 T-Cell Effector Responses in Type-1 Diabetes. Diabetes. PMID 27920091 DOI: 10.2337/Db16-0846 |
0.52 |
|
| 2016 |
Lin B, Ciecko AE, MacKinney E, Serreze DV, Chen YG. Congenic mapping identifies a novel Idd9 subregion regulating type 1 diabetes in NOD mice. Immunogenetics. PMID 27796442 DOI: 10.1007/S00251-016-0957-3 |
0.489 |
|
| 2015 |
Cabrera SM, Wang X, Chen YG, Jia S, Kaldunski ML, Greenbaum CJ, Mandrup-Poulsen T, Hessner MJ. Interleukin-1 antagonism moderates the inflammatory state associated with Type 1 diabetes during clinical trials conducted at disease onset. European Journal of Immunology. PMID 26692253 DOI: 10.1002/Eji.201546005 |
0.311 |
|
| 2015 |
Presa M, Chen YG, Grier AE, Leiter EH, Brehm MA, Greiner DL, Shultz LD, Serreze DV. The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice. Journal of Immunology (Baltimore, Md. : 1950). 195: 3011-9. PMID 26283479 DOI: 10.4049/Jimmunol.1402446 |
0.501 |
|
| 2015 |
Tsaih SW, Presa M, Khaja S, Ciecko AE, Serreze DV, Chen YG. A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. Genes and Immunity. 16: 221-30. PMID 25654212 DOI: 10.1038/gene.2014.81 |
0.387 |
|
| 2014 |
Chen YG, Cabrera SM, Jia S, Kaldunski ML, Kramer J, Cheong S, Geoffrey R, Roethle MF, Woodliff JE, Greenbaum CJ, Wang X, Hessner MJ. Molecular signatures differentiate immune states in type 1 diabetic families. Diabetes. 63: 3960-73. PMID 24760139 DOI: 10.2337/Db14-0214 |
0.388 |
|
| 2014 |
Chen YG, Forsberg MH, Khaja S, Ciecko AE, Hessner MJ, Geurts AM. Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 63: 68-74. PMID 23974926 DOI: 10.2337/Db13-0192 |
0.501 |
|
| 2013 |
Chen YG, Mordes JP, Blankenhorn EP, Kashmiri H, Kaldunski ML, Jia S, Geoffrey R, Wang X, Hessner MJ. Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes. Genes and Immunity. 14: 387-400. PMID 23739610 DOI: 10.1038/Gene.2013.31 |
0.352 |
|
| 2013 |
Tsaih SW, Khaja S, Ciecko AE, MacKinney E, Chen YG. Genetic control of murine invariant natural killer T cells maps to multiple type 1 diabetes regions Genes and Immunity. 14: 380-386. PMID 23719031 DOI: 10.1038/Gene.2013.32 |
0.457 |
|
| 2013 |
Bogdani M, Henschel AM, Kansra S, Fuller JM, Geoffrey R, Jia S, Kaldunski ML, Pavletich S, Prosser S, Chen YG, Lernmark A, Hessner MJ. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. The Journal of Endocrinology. 216: 111-23. PMID 23111281 DOI: 10.1530/Joe-12-0385 |
0.352 |
|
| 2012 |
Driver JP, Chen YG, Mathews CE. Comparative genetics: synergizing human and NOD mouse studies for identifying genetic causation of type 1 diabetes. The Review of Diabetic Studies : Rds. 9: 169-87. PMID 23804259 DOI: 10.1900/RDS.2012.9.169 |
0.344 |
|
| 2012 |
Stolp J, Chen YG, Cox SL, Henck V, Zhang W, Tsaih SW, Chapman H, Stearns T, Serreze DV, Silveira PA. Subcongenic analyses reveal complex interactions between distal chromosome 4 genes controlling diabetogenic B cells and CD4 T cells in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 189: 1406-17. PMID 22732593 DOI: 10.4049/Jimmunol.1200120 |
0.492 |
|
| 2012 |
Chen Y, Tsaih S, Serreze DV. Genetic control of murine invariant natural killer T-cell development dynamically differs dependent on the examined tissue type. Genes and Immunity. 13: 164-174. PMID 21938016 DOI: 10.1038/Gene.2011.68 |
0.363 |
|
| 2011 |
Chen YG, Scheuplein F, Driver JP, Hewes AA, Reifsnyder PC, Leiter EH, Serreze DV. Testing the role of P2X7 receptors in the development of type 1 diabetes in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 4278-84. PMID 21357538 DOI: 10.4049/Jimmunol.1003733 |
0.474 |
|
| 2011 |
Driver JP, Chen YG, Zhang W, Asrat S, Serreze DV. Unmasking genes in a type 1 diabetes-resistant mouse strain that enhances pathogenic CD8 T-cell responses. Diabetes. 60: 1354-9. PMID 21307079 DOI: 10.2337/Db10-0885 |
0.527 |
|
| 2011 |
Driver JP, Serreze DV, Chen YG. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Seminars in Immunopathology. 33: 67-87. PMID 20424843 DOI: 10.1007/S00281-010-0204-1 |
0.458 |
|
| 2010 |
Driver JP, Scheuplein F, Chen YG, Grier AE, Wilson SB, Serreze DV. Invariant natural killer T-cell control of type 1 diabetes: a dendritic cell genetic decision of a silver bullet or Russian roulette. Diabetes. 59: 423-32. PMID 19903740 DOI: 10.2337/Db09-1116 |
0.486 |
|
| 2010 |
Scheuplein F, Rissiek B, Driver JP, Chen YG, Koch-Nolte F, Serreze DV. A recombinant heavy chain antibody approach blocks ART2 mediated deletion of an iNKT cell population that upon activation inhibits autoimmune diabetes. Journal of Autoimmunity. 34: 145-54. PMID 19796917 DOI: 10.1016/J.Jaut.2009.08.012 |
0.452 |
|
| 2010 |
Chen Y, Serreze D. Multiple Genes within the Idd9.1 Region Regulate iNKT Cells and Type 1 Diabetes in NOD Mice Clinical Immunology. 135. DOI: 10.1016/J.Clim.2010.03.341 |
0.458 |
|
| 2008 |
Chen YG, Scheuplein F, Osborne MA, Tsaih SW, Chapman HD, Serreze DV. Idd9/11 genetic locus regulates diabetogenic activity of CD4 T-cells in nonobese diabetic (NOD) mice. Diabetes. 57: 3273-80. PMID 18776136 DOI: 10.2337/Db08-0767 |
0.527 |
|
| 2008 |
Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y, Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP. Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 6374-9. PMID 18430797 DOI: 10.1073/Pnas.0802644105 |
0.389 |
|
| 2007 |
Chen YG, Driver JP, Silveira PA, Serreze DV. Subcongenic analysis of genetic basis for impaired development of invariant NKT cells in NOD mice. Immunogenetics. 59: 705-12. PMID 17619875 DOI: 10.1007/S00251-007-0236-4 |
0.431 |
|
| 2007 |
Chen YG, Silveira PA, Osborne MA, Chapman HD, Serreze DV. Cellular expression requirements for inhibition of type 1 diabetes by a dominantly protective major histocompatibility complex haplotype. Diabetes. 56: 424-30. PMID 17259387 DOI: 10.2337/Db06-1303 |
0.487 |
|
| 2006 |
Serreze DV, Osborne MA, Chen YG, Chapman HD, Pearson T, Brehm MA, Greiner DL. Partial versus full allogeneic hemopoietic chimerization is a preferential means to inhibit type 1 diabetes as the latter induces generalized immunosuppression. Journal of Immunology (Baltimore, Md. : 1950). 177: 6675-84. PMID 17082580 DOI: 10.4049/Jimmunol.177.10.6675 |
0.496 |
|
| 2006 |
Chen YG, Chen J, Osborne MA, Chapman HD, Besra GS, Porcelli SA, Leiter EH, Wilson SB, Serreze DV. CD38 is required for the peripheral survival of immunotolerogenic CD4+ invariant NK T cells in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 177: 2939-47. PMID 16920929 DOI: 10.4049/Jimmunol.177.5.2939 |
0.426 |
|
| 2006 |
Chen J, Chen YG, Reifsnyder PC, Schott WH, Lee CH, Osborne M, Scheuplein F, Haag F, Koch-Nolte F, Serreze DV, Leiter EH. Targeted disruption of CD38 accelerates autoimmune diabetes in NOD/Lt mice by enhancing autoimmunity in an ADP-ribosyltransferase 2-dependent fashion. Journal of Immunology (Baltimore, Md. : 1950). 176: 4590-9. PMID 16585549 DOI: 10.4049/Jimmunol.176.8.4590 |
0.467 |
|
| 2006 |
Lee CH, Chen YG, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH. Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis. Diabetes. 55: 171-8. PMID 16380490 |
0.434 |
|
| 2005 |
Serreze DV, Chen YG. Of mice and men: use of animal models to identify possible interventions for the prevention of autoimmune type 1 diabetes in humans. Trends in Immunology. 26: 603-7. PMID 16140038 DOI: 10.1016/J.It.2005.08.012 |
0.457 |
|
| 2005 |
Chen YG, Choisy-Rossi CM, Holl TM, Chapman HD, Besra GS, Porcelli SA, Shaffer DJ, Roopenian D, Wilson SB, Serreze DV. Activated NKT cells inhibit autoimmune diabetes through tolerogenic recruitment of dendritic cells to pancreatic lymph nodes. Journal of Immunology (Baltimore, Md. : 1950). 174: 1196-204. PMID 15661873 DOI: 10.4049/Jimmunol.174.3.1196 |
0.343 |
|
| 2005 |
Lee C, Chen Y, Chen J, Reifsnyder PC, Serreze DV, Clare-Salzler M, Rodriguez M, Wasserfall C, Atkinson MA, Leiter EH. Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis Diabetes. 55: 171-178. DOI: 10.2337/Diabetes.55.01.06.Db05-1129 |
0.51 |
|
| 2002 |
Omasa T, Chen YG, Mantalaris A, Tsai YC, Wu JH. Molecular cloning and sequencing of the human heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase from bone marrow culture. Dna Sequence : the Journal of Dna Sequencing and Mapping. 13: 133-7. PMID 12391722 DOI: 10.1080/10425170290023428 |
0.481 |
|
| 2001 |
Omasa T, Chen Y, Mantalaris A, Wu JHD. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP1γ1/PLM/MAT8 family of transmembrane proteins Biochimica Et Biophysica Acta. 1517: 307-310. PMID 11342114 DOI: 10.1016/S0167-4781(00)00251-7 |
0.488 |
|
| 1999 |
Ou-Yang P, Chiang B, Hwang L, Chen Y, Yang P, Chi W, Chen P, Chen D. Characterization of monoclonal antibodies against hepatitis C virus nonstructural protein 3: different antigenic determinants from human B cells. Journal of Medical Virology. 57: 345-350. PMID 10089044 DOI: 10.1002/(Sici)1096-9071(199904)57:4<345::Aid-Jmv3>3.0.Co;2-N |
0.305 |
|
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