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Elsje Pienaar, Ph.D. - Publications

Affiliations: 
2010 Chemical and Biomolecular Engineering The University of Nebraska - Lincoln, Lincoln, NE 
Area:
Chemical Engineering, Molecular Biology, Applied Mathematics
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36 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Weathered C, Bardehle S, Yoon C, Kumar N, Leyns CEG, Kennedy ME, Bloomingdale P, Pienaar E. Microglial Roles in Alzheimer's Disease: An Agent-Based Model to Elucidate Microglial Spatiotemporal Response to Beta-Amyloid. Cpt: Pharmacometrics & Systems Pharmacology. PMID 38078626 DOI: 10.1002/psp4.13095  0.735
2023 Cody JW, Ellis-Connell AL, O'Connor SL, Pienaar E. Mathematical modeling indicates that regulatory inhibition of CD8+ T cell cytotoxicity can limit efficacy of IL-15 immunotherapy in cases of high pre-treatment SIV viral load. Plos Computational Biology. 19: e1011425. PMID 37616311 DOI: 10.1371/journal.pcbi.1011425  0.727
2023 Liu X, Husby M, Stahelin RV, Pienaar E. Evaluation of Fendiline Treatment in VP40 System with Nucleation-Elongation Process: A Computational Model of Ebola Virus Matrix Protein Assembly. Biorxiv : the Preprint Server For Biology. PMID 37577722 DOI: 10.1101/2023.08.03.551833  0.32
2023 Weathered C, Wei N, Pienaar E. Reduced macrophage killing of M. avium drives infection risk in post-menopausal patients. Tuberculosis (Edinburgh, Scotland). 139: 102304. PMID 36682272 DOI: 10.1016/j.tube.2023.102304  0.758
2022 Weathered C, Pennington K, Escalante P, Pienaar E. Agent-based model indicates chemoattractant signaling caused by Mycobacterium avium biofilms in the lung airway increases bacterial loads by spatially diverting macrophages. Tuberculosis (Edinburgh, Scotland). 138: 102300. PMID 36621288 DOI: 10.1016/j.tube.2022.102300  0.759
2022 Hoerter A, Arnett E, Schlesinger LS, Pienaar E. Systems biology approaches to investigate the role of granulomas in TB-HIV coinfection. Frontiers in Immunology. 13: 1014515. PMID 36405707 DOI: 10.3389/fimmu.2022.1014515  0.681
2022 Liu X, Pappas EJ, Husby ML, Motsa BB, Stahelin RV, Pienaar E. Mechanisms of phosphatidylserine influence on viral production: a computational model of Ebola virus matrix protein assembly. The Journal of Biological Chemistry. 102025. PMID 35568195 DOI: 10.1016/j.jbc.2022.102025  0.303
2022 Pennington KM, Katta R, Weathered C, Pienaar E, Escalante P. Characteristics and outcomes of anti-mycobacterial therapy compared to no anti-mycobacterial therapy for NTM pulmonary disease. Respiratory Medicine. 197: 106829. PMID 35364522 DOI: 10.1016/j.rmed.2022.106829  0.719
2021 Weathered C, Pennington K, Escalante P, Pienaar E. The Role of Biofilms, Bacterial Phenotypes, and Innate Immune Response in Mycobacterium avium Colonization to Infection. Journal of Theoretical Biology. 110949. PMID 34717938 DOI: 10.1016/j.jtbi.2021.110949  0.772
2021 Cody JW, Ellis-Connell AL, O'Connor SL, Pienaar E. Mathematical modeling of N-803 treatment in SIV-infected non-human primates. Plos Computational Biology. 17: e1009204. PMID 34319980 DOI: 10.1371/journal.pcbi.1009204  0.734
2019 Elkington P, Lerm M, Kapoor N, Mahon R, Pienaar E, Huh D, Kaushal D, Schlesinger LS. In Vitro Granuloma Models of Tuberculosis: Potential and Challenges. The Journal of Infectious Diseases. PMID 30929010 DOI: 10.1093/Infdis/Jiz020  0.373
2019 Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Liang HH, Prideaux B, Dietzold J, Salgame P, Savic R, Linderman J, Kirschner D, ... Pienaar E, et al. Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations. Antimicrobial Agents and Chemotherapy. PMID 30803965 DOI: 10.1128/Aac.02516-18  0.305
2018 Pienaar E, Linderman JJ, Kirschner DE. Emergence and selection of isoniazid and rifampin resistance in tuberculosis granulomas. Plos One. 13: e0196322. PMID 29746491 DOI: 10.1371/Journal.Pone.0196322  0.306
2017 Kirschner D, Pienaar E, Marino S, Linderman JJ. A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment. Current Opinion in Systems Biology. 3: 170-185. PMID 30714019 DOI: 10.1016/J.Coisb.2017.05.014  0.413
2017 Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE. Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model. Frontiers in Immunology. 8: 1843. PMID 29326718 DOI: 10.3389/Fimmu.2017.01843  0.387
2017 Cicchese JM, Pienaar E, Kirschner DE, Linderman JJ. Applying optimization algorithms to tuberculosis antibiotic treatment regimens. Cellular and Molecular Bioengineering. 10: 523-535. PMID 29276546 DOI: 10.1007/S12195-017-0507-6  0.314
2017 Pienaar E, Sarathy J, Prideaux B, Dietzold J, Dartois V, Kirschner DE, Linderman JJ. Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach. Plos Computational Biology. 13: e1005650. PMID 28817561 DOI: 10.1371/Journal.Pcbi.1005650  0.358
2016 Pienaar E, Matern WM, Linderman JJ, Bader JS, Kirschner DE. Multi-scale model of Mycobacterium tuberculosis infection maps metabolite and gene perturbations to granuloma sterilization predictions. Infection and Immunity. PMID 26975995 DOI: 10.1128/Iai.01438-15  0.368
2015 Pienaar E, Dartois V, Linderman JJ, Kirschner DE. In silico evaluation and exploration of antibiotic tuberculosis treatment regimens. Bmc Systems Biology. 9: 79. PMID 26578235 DOI: 10.1186/S12918-015-0221-8  0.372
2015 Linderman JJ, Cilfone NA, Pienaar E, Gong C, Kirschner DE. A multi-scale approach to designing therapeutics for tuberculosis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 591-609. PMID 25924949 DOI: 10.1039/C4Ib00295D  0.36
2015 Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ. A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. Journal of Theoretical Biology. 367: 166-79. PMID 25497475 DOI: 10.1016/J.Jtbi.2014.11.021  0.411
2014 Raffetseder J, Pienaar E, Blomgran R, Eklund D, Patcha Brodin V, Andersson H, Welin A, Lerm M. Replication rates of Mycobacterium tuberculosis in human macrophages do not correlate with mycobacterial antibiotic susceptibility. Plos One. 9: e112426. PMID 25386849 DOI: 10.1371/Journal.Pone.0112426  0.364
2014 Pienaar E, Lerm M. A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages. Journal of Theoretical Biology. 342: 23-32. PMID 24112967 DOI: 10.1016/J.Jtbi.2013.09.029  0.397
2014 Pienaar E, Lerm M. Erratum to “A mathematical model of the initial interaction between Mycobacterium tuberculosis and macrophages” [J. Theoret. Biol. 342 (2014) 23–32] Journal of Theoretical Biology. 349: 172. DOI: 10.1016/J.Jtbi.2014.02.007  0.31
2014 Cilfone NA, Pienaar E, Kirschner DE, Linderman JJ. Computational Modeling of Granuloma Formation in Tuberculosis Yields Insights into both Infection and Treatment Biophysical Journal. 106: 644a. DOI: 10.1016/J.Bpj.2013.11.3565  0.418
2012 Viljoen S, Pienaar E, Viljoen HJ. A state-time epidemiology model of tuberculosis: importance of re-infection. Computational Biology and Chemistry. 36: 15-22. PMID 22340441 DOI: 10.1016/J.Compbiolchem.2011.11.003  0.597
2011 Louw TM, Booth CS, Pienaar E, Termaat JR, Whitney SE, Viljoen HJ. Experimental Validation of a Fundamental Model for PCR Efficiency. Chemical Engineering Science. 66: 1783-1789. PMID 21822325 DOI: 10.1016/J.Ces.2011.01.029  0.745
2011 Louw TM, Whitney SE, Termaat JR, Pienaar E, Viljoen HJ. Oligonucleotide optimization for DNA synthesis Aiche Journal. 57: 1912-1918. DOI: 10.1002/Aic.12410  0.732
2010 Booth CS, Pienaar E, Termaat JR, Whitney SE, Louw TM, Viljoen HJ. Efficiency of the Polymerase Chain Reaction. Chemical Engineering Science. 65: 4996-5006. PMID 21799540 DOI: 10.1016/J.Ces.2010.05.046  0.742
2010 Pienaar E, Fluitt AM, Whitney SE, Freifeld AG, Viljoen HJ. A model of tuberculosis transmission and intervention strategies in an urban residential area. Computational Biology and Chemistry. 34: 86-96. PMID 20381428 DOI: 10.1016/J.Compbiolchem.2010.03.003  0.624
2009 Valente W, Pienaar E, Fast A, Fluitt A, Whitney S, Fenton R, Barletta R, Chacon O, Viljoen H. A Kinetic Study of In Vitro Lysis of Mycobacterium smegmatis. Chemical Engineering Science. 64: 1944-1952. PMID 21451732 DOI: 10.1016/J.Ces.2008.12.015  0.632
2009 Pienaar E, Whitney SE, Viljoen HJ, van Rensburg NF. A model of the complex response of Staphylococcus aureus to methicillin. Journal of Theoretical Biology. 257: 438-45. PMID 19135063 DOI: 10.1016/J.Jtbi.2008.12.003  0.61
2008 Mamedov TG, Pienaar E, Whitney SE, TerMaat JR, Carvill G, Goliath R, Subramanian A, Viljoen HJ. A fundamental study of the PCR amplification of GC-rich DNA templates. Computational Biology and Chemistry. 32: 452-7. PMID 18760969 DOI: 10.1016/J.Compbiolchem.2008.07.021  0.595
2008 Pienaar E, Viljoen HJ. The tri-frame model. Journal of Theoretical Biology. 251: 616-27. PMID 18237749 DOI: 10.1016/J.Jtbi.2007.12.003  0.576
2007 Fluitt A, Pienaar E, Viljoen H. Ribosome kinetics and aa-tRNA competition determine rate and fidelity of peptide synthesis. Computational Biology and Chemistry. 31: 335-46. PMID 17897886 DOI: 10.1016/J.Compbiolchem.2007.07.003  0.571
2006 Pienaar E, Theron M, Nelson M, Viljoen HJ. A quantitative model of error accumulation during PCR amplification. Computational Biology and Chemistry. 30: 102-11. PMID 16412692 DOI: 10.1016/J.Compbiolchem.2005.11.002  0.58
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