George K. Aghajanian - Publications

Affiliations: 
Yale University, New Haven, CT 

247 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nature Medicine. 22: 238-49. PMID 26937618 DOI: 10.1038/nm.4050  0.72
2015 Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America. 112: 8106-11. PMID 26056286 DOI: 10.1073/pnas.1414728112  1
2015 Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK. Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2066-75. PMID 25759300 DOI: 10.1038/npp.2015.70  1
2014 Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine. 20: 531-5. PMID 24728411 DOI: 10.1038/nm.3513  1
2014 Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience. 17: 248-53. PMID 24441680 DOI: 10.1038/nn.3625  1
2014 Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 233. PMID 24317309 DOI: 10.1038/npp.2013.217  1
2013 Voleti B, Navarria A, Liu RJ, Banasr M, Li N, Terwilliger R, Sanacora G, Eid T, Aghajanian G, Duman RS. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biological Psychiatry. 74: 742-9. PMID 23751205 DOI: 10.1016/j.biopsych.2013.04.025  1
2013 Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK. GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2268-77. PMID 23680942 DOI: 10.1038/npp.2013.128  1
2012 Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science (New York, N.Y.). 338: 68-72. PMID 23042884 DOI: 10.1126/science.1222939  1
2012 Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological Psychiatry. 71: 996-1005. PMID 22036038 DOI: 10.1016/j.biopsych.2011.09.030  1
2012 Duman RS, Li N, Liu RJ, Duric V, Aghajanian G. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology. 62: 35-41. PMID 21907221 DOI: 10.1016/j.neuropharm.2011.08.044  1
2011 Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biological Psychiatry. 69: 754-61. PMID 21292242 DOI: 10.1016/j.biopsych.2010.12.015  1
2010 Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science (New York, N.Y.). 329: 959-64. PMID 20724638 DOI: 10.1126/science.1190287  1
2010 Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8263-73. PMID 20554878 DOI: 10.1523/JNEUROSCI.5858-09.2010  1
2010 Aghajanian G, Liu RJ. Serotonin (5-Hydroxytryptamine; 5-HT): CNS Pathways and Neurophysiology Encyclopedia of Neuroscience. 715-722. DOI: 10.1016/B978-008045046-9.01159-1  1
2008 Zachariou V, Liu R, LaPlant Q, Xiao G, Renthal W, Chan GC, Storm DR, Aghajanian G, Nestler EJ. Distinct roles of adenylyl cyclases 1 and 8 in opiate dependence: behavioral, electrophysiological, and molecular studies. Biological Psychiatry. 63: 1013-21. PMID 18222416 DOI: 10.1016/j.biopsych.2007.11.021  1
2008 Liu RJ, Aghajanian GK. Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy. Proceedings of the National Academy of Sciences of the United States of America. 105: 359-64. PMID 18172209 DOI: 10.1073/pnas.0706679105  1
2007 Lambe EK, Liu RJ, Aghajanian GK. Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophrenia Bulletin. 33: 1284-90. PMID 17656637 DOI: 10.1093/schbul/sbm088  1
2007 Lambe EK, Aghajanian GK. Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation. Neuroscience. 145: 900-10. PMID 17293055 DOI: 10.1016/j.neuroscience.2006.12.048  1
2007 Heninger GR, Krystal JH, Duman RS, Bunney BS, Bowers MB, Aghajanian GK. The Neuroscience Research Program at the Connecticut Mental Health Center 40 Years of Academic Public Psychiatry. 77-95. DOI: 10.1002/9780470994580.ch4  1
2006 Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, et al. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (New York, N.Y.). 313: 536-40. PMID 16873667 DOI: 10.1126/science.1123432  1
2006 Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4624-9. PMID 16641242 DOI: 10.1523/JNEUROSCI.4701-05.2006  1
2006 Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of Neurobiology. 66: 408-20. PMID 16408297 DOI: 10.1002/neu.20233  1
2006 Lambe EK, Aghajanian GK. Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1682-9. PMID 16292328 DOI: 10.1038/sj.npp.1300944  1
2005 Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5225-9. PMID 15917462 DOI: 10.1523/JNEUROSCI.0719-05.2005  1
2005 Liu RJ, Lambe EK, Aghajanian GK. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. The European Journal of Neuroscience. 21: 945-58. PMID 15787701 DOI: 10.1111/j.1460-9568.2005.03930.x  1
2005 Lambe EK, Aghajanian GK. Effects of hypocretin/orexin on the thalamocortical activating system Hypocretins: Integrators of Physiological Functions. 191-202. DOI: 10.1007/0-387-25446-3_12  1
2003 Lambe EK, Aghajanian GK. Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron. 40: 139-50. PMID 14527439 DOI: 10.1016/S0896-6273(03)00598-1  1
2003 Gold SJ, Han MH, Herman AE, Ni YG, Pudiak CM, Aghajanian GK, Liu RJ, Potts BW, Mumby SM, Nestler EJ. Regulation of RGS proteins by chronic morphine in rat locus coeruleus. The European Journal of Neuroscience. 17: 971-80. PMID 12653973 DOI: 10.1046/j.1460-9568.2003.02529.x  1
2003 Lambe EK, Picciotto MR, Aghajanian GK. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 216-25. PMID 12589374 DOI: 10.1038/sj.npp.1300032  1
2002 Liu RJ, van den Pol AN, Aghajanian GK. Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9453-64. PMID 12417670  1
2002 Liu R, Ding Y, Aghajanian GK. Neurokinins activate local glutamatergic inputs to serotonergic neurons of the dorsal raphe nucleus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 329-40. PMID 12225691 DOI: 10.1016/S0893-133X(02)00305-6  1
2002 Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4153-62. PMID 12019333  1
2002 van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB. Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. The Journal of Physiology. 541: 169-85. PMID 12015428 DOI: 10.1113/jphysiol.2002.017426  1
2001 Lambe EK, Aghajanian GK. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9955-63. PMID 11739602  1
2001 Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, ... Aghajanian GK, et al. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry. 6: 593-604. PMID 11526474 DOI: 10.1038/sj.mp.4000897  1
2001 Stutzmann GE, Marek GJ, Aghajanian GK. Adenosine preferentially suppresses serotonin2A receptor-enhanced excitatory postsynaptic currents in layer V neurons of the rat medial prefrontal cortex. Neuroscience. 105: 55-69. PMID 11483300 DOI: 10.1016/S0306-4522(01)00170-1  1
2000 Lambe EK, Goldman-Rakic PS, Aghajanian GK. Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. Cerebral Cortex (New York, N.Y. : 1991). 10: 974-80. PMID 11007548  1
2000 Liu R, Jolas T, Aghajanian G. Serotonin 5-HT2 receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus Brain Research. 873: 34-45. PMID 10915808 DOI: 10.1016/S0006-8993(00)02468-9  1
2000 Aghajanian GK, Marek GJ. Serotonin model of schizophrenia: emerging role of glutamate mechanisms. Brain Research. Brain Research Reviews. 31: 302-12. PMID 10719157 DOI: 10.1016/S0165-0173(99)00046-6  1
2000 Abellán MT, Jolas T, Aghajanian GK, Artigas F. Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies. Synapse (New York, N.Y.). 36: 21-34. PMID 10700023 DOI: 10.1002/(SICI)1098-2396(200004)36:1<21::AID-SYN3>3.0.CO;2-D  1
2000 Jolas T, Nestler EJ, Aghajanian GK. Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway. Neuroscience. 95: 433-43. PMID 10658623 DOI: 10.1016/S0306-4522(99)00436-4  1
2000 Marek GJ, Wright RA, Schoepp DD, Monn JA, Aghajanian GK. Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex. The Journal of Pharmacology and Experimental Therapeutics. 292: 76-87. PMID 10604933  1
1999 Nestler EJ, Alreja M, Aghajanian GK. Molecular control of locus coeruleus neurotransmission. Biological Psychiatry. 46: 1131-9. PMID 10560020 DOI: 10.1016/S0006-3223(99)00158-4  1
1999 Lieberman JA, Aghajanian GK. Caveat emptor: researcher beware. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 471-3. PMID 10481829 DOI: 10.1016/S0893-133X(99)00071-8  1
1999 Aghajanian GK, Marek GJ. Serotonin and hallucinogens. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 16S-23S. PMID 10432484 DOI: 10.1016/S0893-133X(98)00135-3  1
1999 Aghajanian GK, Marek GJ. Serotonin, via 5-HT2A receptors, increases EPSCs in layer V pyramidal cells of prefrontal cortex by an asynchronous mode of glutamate release. Brain Research. 825: 161-71. PMID 10216183 DOI: 10.1016/S0006-8993(99)01224-X  1
1999 Marek GJ, Aghajanian GK. 5-HT2A receptor or alpha1-adrenoceptor activation induces excitatory postsynaptic currents in layer V pyramidal cells of the medial prefrontal cortex. European Journal of Pharmacology. 367: 197-206. PMID 10078993 DOI: 10.1016/S0014-2999(98)00945-5  1
1999 Aghajanian GK, Marek GJ. Serotonin-glutamate interactions: A new target for antipsychotic drugs Neuropsychopharmacology. 21: S122-S133. DOI: 10.1016/S0893-133X(99)00106-2  1
1999 Krystal JH, Belger A, D'Souza DC, Anand A, Charney DS, Aghajanian GK, Moghaddam B. Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists Neuropsychopharmacology. 21: S143-S157. DOI: 10.1016/S0893-133X(99)00102-5  1
1999 Schoepp DD, Monn JA, Marek GJ, Aghajanian G, Moghaddam B. LY354740: A systemically active mGlu2/mGlu3 receptor agonist Cns Drug Reviews. 5: 1-12.  1
1998 Marek GJ, Aghajanian GK. 5-Hydroxytryptamine-induced excitatory postsynaptic currents in neocortical layer V pyramidal cells: suppression by mu-opiate receptor activation. Neuroscience. 86: 485-97. PMID 9881863 DOI: 10.1016/S0306-4522(98)00043-8  1
1998 Marek GJ, Aghajanian GK. The electrophysiology of prefrontal serotonin systems: therapeutic implications for mood and psychosis. Biological Psychiatry. 44: 1118-27. PMID 9836015 DOI: 10.1016/S0006-3223(98)00036-5  1
1998 Marek GJ, Aghajanian GK. Indoleamine and the phenethylamine hallucinogens: mechanisms of psychotomimetic action. Drug and Alcohol Dependence. 51: 189-98. PMID 9716940 DOI: 10.1016/S0376-8716(98)00076-3  1
1997 Jolas T, Aghajanian GK. Neurotensin and the serotonergic system. Progress in Neurobiology. 52: 455-68. PMID 9316156 DOI: 10.1016/S0301-0082(97)00025-7  1
1997 Lane-Ladd SB, Pineda J, Boundy VA, Pfeuffer T, Krupinski J, Aghajanian GK, Nestler EJ. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7890-901. PMID 9315909  1
1997 Nestler EJ, Aghajanian GK. Molecular and cellular basis of addiction. Science (New York, N.Y.). 278: 58-63. PMID 9311927 DOI: 10.1126/science.278.5335.58  1
1997 Aghajanian GK, Marek GJ. Serotonin induces excitatory postsynaptic potentials in apical dendrites of neocortical pyramidal cells. Neuropharmacology. 36: 589-99. PMID 9225284 DOI: 10.1016/S0028-3908(97)00051-8  1
1997 Jolas T, Aghajanian GK. Opioids suppress spontaneous and NMDA-induced inhibitory postsynaptic currents in the dorsal raphe nucleus of the rat in vitro. Brain Research. 755: 229-45. PMID 9175891 DOI: 10.1016/S0006-8993(97)00103-0  1
1997 Vaidya VA, Marek GJ, Aghajanian GK, Duman RS. 5-HT2A receptor-mediated regulation of brain-derived neurotrophic factor mRNA in the hippocampus and the neocortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2785-95. PMID 9092600  1
1997 Pineda J, Aghajanian GK. Carbon dioxide regulates the tonic activity of locus coeruleus neurons by modulating a proton- and polyamine-sensitive inward rectifier potassium current. Neuroscience. 77: 723-43. PMID 9070748 DOI: 10.1016/S0306-4522(96)00485-X  1
1997 Abi-Dargham A, Laruelle M, Aghajanian GK, Charney D, Krystal J. The role of serotonin in the pathophysiology and treatment of schizophrenia. The Journal of Neuropsychiatry and Clinical Neurosciences. 9: 1-17. PMID 9017523  1
1996 Rasmussen K, Kendrick WT, Kogan JH, Aghajanian GK. A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 497-505. PMID 8914123 DOI: 10.1016/S0893-133X(96)00094-2  1
1996 McDougle CJ, Naylor ST, Cohen DJ, Aghajanian GK, Heninger GR, Price LH. Effects of tryptophan depletion in drug-free adults with autistic disorder. Archives of General Psychiatry. 53: 993-1000. PMID 8911222  1
1996 Marek GJ, Aghajanian GK. LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex. The Journal of Pharmacology and Experimental Therapeutics. 278: 1373-82. PMID 8819525  1
1996 Marek GJ, Aghajanian GK. Alpha 1B-adrenoceptor-mediated excitation of piriform cortical interneurons. European Journal of Pharmacology. 305: 95-100. PMID 8813537  1
1996 Pineda J, Kogan JH, Aghajanian GK. Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 1389-99. PMID 8778290  1
1995 Marek GJ, Aghajanian GK. Protein kinase C inhibitors enhance the 5-HT2A receptor-mediated excitatory effects of serotonin on interneurons in rat piriform cortex. Synapse (New York, N.Y.). 21: 123-30. PMID 8584973 DOI: 10.1002/syn.890210205  1
1995 Kogan JH, Aghajanian GK. Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal. Brain Research. 689: 111-21. PMID 8528694 DOI: 10.1016/0006-8993(95)00545-2  1
1995 Alreja M, Aghajanian GK. Use of the whole-cell patch-clamp method in studies on the role of cAMP in regulating the spontaneous firing of locus coeruleus neurons. Journal of Neuroscience Methods. 59: 67-75. PMID 7475253 DOI: 10.1016/0165-0270(94)00195-M  1
1994 Alreja M, Aghajanian GK. QX-314 blocks the potassium but not the sodium-dependent component of the opiate response in locus coeruleus neurons. Brain Research. 639: 320-4. PMID 8205485 DOI: 10.1016/0006-8993(94)91746-9  1
1994 Marek GJ, Aghajanian GK. Excitation of interneurons in piriform cortex by 5-hydroxytryptamine: blockade by MDL 100,907, a highly selective 5-HT2A receptor antagonist. European Journal of Pharmacology. 259: 137-41. PMID 7957607 DOI: 10.1016/0014-2999(94)90502-9  1
1994 Iyer RN, Sprouse JS, Aghajanian GK, Roth RH, Bradberry CW. Tryptophan pretreatment augmentation of p-chloroamphetamine-induced serotonin and dopamine release and reduction of long-term neurotoxicity. Biochemical Pharmacology. 48: 1501-8. PMID 7945451 DOI: 10.1016/0006-2952(94)90576-2  1
1994 Delgado PL, Price LH, Miller HL, Salomon RM, Aghajanian GK, Heninger GR, Charney DS. Serotonin and the neurobiology of depression. Effects of tryptophan depletion in drug-free depressed patients. Archives of General Psychiatry. 51: 865-74. PMID 7944875 DOI: 10.1001/archpsyc.1994.03950110025005  1
1994 Aghajanian GK, Kogan JH, Moghaddam B. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Research. 636: 126-30. PMID 7908850 DOI: 10.1016/0006-8993(94)90186-4  1
1994 Nestler EJ, Alreja M, Aghajanian GK. Molecular and cellular mechanisms of opiate action: studies in the rat locus coeruleus. Brain Research Bulletin. 35: 521-8. PMID 7859110 DOI: 10.1016/0361-9230(94)90166-X  1
1994 Gellman RL, Aghajanian GK. Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: antagonism by atypical antipsychotic drugs. Neuroscience. 58: 515-25. PMID 7513386 DOI: 10.1016/0306-4522(94)90077-9  1
1993 Guitart X, Kogan JH, Berhow M, Terwilliger RZ, Aghajanian GK, Nestler EJ. Lewis and Fischer rat strains display differences in biochemical, electrophysiological and behavioral parameters: studies in the nucleus accumbens and locus coeruleus of drug naive and morphine-treated animals. Brain Research. 611: 7-17. PMID 8518951 DOI: 10.1016/0006-8993(93)91770-S  1
1993 Garratt JC, Alreja M, Aghajanian GK. LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: intracellular studies in rat facial motoneurons. Synapse (New York, N.Y.). 13: 123-34. PMID 8446921 DOI: 10.1002/syn.890130205  1
1993 Gellman RL, Aghajanian GK. Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons. Brain Research. 600: 63-73. PMID 8422591 DOI: 10.1016/0006-8993(93)90402-9  1
1993 Alreja M, Aghajanian GK. Opiates suppress a resting sodium-dependent inward current and activate an outward potassium current in locus coeruleus neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 3525-32. PMID 8393484  1
1993 Krystal JH, Seibyl JP, Price LH, Woods SW, Heninger GR, Aghajanian GK, Charney DS. m-Chlorophenylpiperazine effects in neuroleptic-free schizophrenic patients. Evidence implicating serotonergic systems in the positive symptoms of schizophrenia. Archives of General Psychiatry. 50: 624-35. PMID 8102048 DOI: 10.1001/archpsyc.1993.01820200034004  1
1992 Kogan JH, Nestler EJ, Aghajanian GK. Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. European Journal of Pharmacology. 211: 47-53. PMID 1618268 DOI: 10.1016/0014-2999(92)90261-2  1
1992 Heninger GR, Delgado PL, Charney DS, Price LH, Aghajanian GK. Tryptophan-deficient diet and amino acid drink deplete plasma tryptophan and induce a relapse of depression in susceptible patients. Journal of Chemical Neuroanatomy. 5: 347-8. PMID 1524722 DOI: 10.1016/0891-0618(92)90025-L  1
1992 Aghajanian GK, Alreja M, Nestler EJ, Kogan JH. Dual mechanisms of opiate dependence in the locus coeruleus. Clinical Neuropharmacology. 15: 143A-144A. PMID 1498786  1
1992 Krystal JH, McDougle CJ, Kosten TR, Price LH, Aghajanian GK, Charney DS. Baclofen-assisted detoxification from opiates. A pilot study. Journal of Substance Abuse Treatment. 9: 139-42. PMID 1324986 DOI: 10.1016/0740-5472(92)90081-X  1
1991 Sheldon PW, Aghajanian GK. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT1C receptors in pyramidal cells and 5-HT2 receptors in interneurons. Synapse (New York, N.Y.). 9: 208-18. PMID 1776132 DOI: 10.1002/syn.890090307  1
1991 Rasmussen K, Krystal JH, Aghajanian GK. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology. 105: 508-12. PMID 1771218 DOI: 10.1007/BF02244371  1
1991 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. Sub-picogram determination of serotonin using HPLC with electrochemical detection for microdialysis studies of serotonin release. Advances in Experimental Medicine and Biology. 294: 81-9. PMID 1685295  1
1991 Bradberry CW, Sprouse JS, Sheldon PW, Aghajanian GK, Roth RH. In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements. Journal of Neuroscience Methods. 36: 85-90. PMID 1676433 DOI: 10.1016/0165-0270(91)90141-L  1
1991 Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research. 4: 121-56. PMID 1674882 DOI: 10.1016/0920-9964(91)90030-U  1
1991 Alreja M, Aghajanian GK. Activation of locus coeruleus (LC) neurones by cholera toxin: mediation by cAMP-dependent protein kinase. Neuroscience Letters. 134: 113-7. PMID 1667677 DOI: 10.1016/0304-3940(91)90520-4  1
1991 Alreja M, Aghajanian GK. Pacemaker activity of locus coeruleus neurons: whole-cell recordings in brain slices show dependence on cAMP and protein kinase A. Brain Research. 556: 339-43. PMID 1657308 DOI: 10.1016/0006-8993(91)90327-R  1
1990 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. 3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan. Neurochemistry International. 17: 509-13. PMID 20504652 DOI: 10.1016/0197-0186(90)90037-T  1
1990 Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse (New York, N.Y.). 5: 324-32. PMID 2360199 DOI: 10.1002/syn.890050409  1
1990 Delgado PL, Charney DS, Price LH, Aghajanian GK, Landis H, Heninger GR. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Archives of General Psychiatry. 47: 411-8. PMID 2184795 DOI: 10.1001/archpsyc.1990.01810170011002  1
1990 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: role of a cAMP and protein kinase A. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3335-43. PMID 2170595  1
1990 Aghajanian GK, Sprouse JS, Sheldon P, Rasmussen K. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Annals of the New York Academy of Sciences. 600: 93-103; discussion 1. PMID 2123618  1
1990 Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2308-17. PMID 2115910  1
1990 Sheldon PW, Aghajanian GK. Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2-activated interneuron. Brain Research. 506: 62-9. PMID 2105822 DOI: 10.1016/0006-8993(90)91199-Q  1
1990 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. European Journal of Pharmacology. 178: 313-20. PMID 1971220 DOI: 10.1016/0014-2999(90)90110-R  1
1989 Rasmussen K, Aghajanian GK. Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei. Synapse (New York, N.Y.). 4: 162-4. PMID 2781467 DOI: 10.1002/syn.890040210  1
1989 Aghajanian GK, Rasmussen K. Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse (New York, N.Y.). 3: 331-8. PMID 2740992 DOI: 10.1002/syn.890030406  1
1989 Rasmussen K, Aghajanian GK. Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Research. 505: 346-50. PMID 2598056 DOI: 10.1016/0006-8993(89)91466-2  1
1989 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin. European Journal of Pharmacology. 167: 375-83. PMID 2572435 DOI: 10.1016/0014-2999(89)90446-9  1
1989 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by vasoactive intestinal peptide: evidence for a G-protein-mediated inward current. Brain Research. 500: 107-18. PMID 2514005 DOI: 10.1016/0006-8993(89)90304-1  1
1988 Innis RB, Nestler EJ, Aghajanian GK. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Research. 459: 27-36. PMID 3139262 DOI: 10.1016/0006-8993(88)90282-X  1
1988 Rasmussen K, Aghajanian GK. Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 1: 101-7. PMID 2908015  1
1988 Sprouse JS, Aghajanian GK. Responses of hippocampal pyramidal cells to putative serotonin 5-HT1A and 5-HT1B agonists: a comparative study with dorsal raphe neurons. Neuropharmacology. 27: 707-15. PMID 2901680 DOI: 10.1016/0028-3908(88)90079-2  1
1987 Sprouse JS, Aghajanian GK. Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse (New York, N.Y.). 1: 3-9. PMID 3505364 DOI: 10.1002/syn.890010103  1
1987 Burlhis TM, Aghajanian GK. Pacemaker potentials of serotonergic dorsal raphe neurons: contribution of a low-threshold Ca2+ conductance. Synapse (New York, N.Y.). 1: 582-8. PMID 3455563 DOI: 10.1002/syn.890010611  1
1987 Wang YY, Aghajanian GK. Intracellular GTP gamma S restores the ability of morphine to hyperpolarize rat locus coeruleus neurons after blockade by pertussis toxin. Brain Research. 436: 396-401. PMID 3124929 DOI: 10.1016/0006-8993(87)91687-8  1
1987 Kehne JH, Cassella JV, Aghajanian GK, Tallman JF, Davis M. Pertussis toxin or 8-bromo-cAMP block inhibition of the acoustic startle response by the alpha 2-adrenergic agonist ST-91. Brain Research. 406: 87-92. PMID 3032362 DOI: 10.1016/0006-8993(87)90771-2  1
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Research. 411: 139-43. PMID 2955848 DOI: 10.1016/0006-8993(87)90690-1  1
1987 Freedman JE, Aghajanian GK. Role of phosphoinositide metabolites in the prolongation of afterhyperpolarizations by alpha 1-adrenoceptors in rat dorsal raphe neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 3897-906. PMID 2826720  1
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. European Journal of Pharmacology. 143: 195-204. PMID 2826189 DOI: 10.1016/0014-2999(87)90533-4  1
1987 Wang YY, Aghajanian GK. Excitation of locus coeruleus neurons by an adenosine 3',5'-cyclic monophosphate-activated inward current: extracellular and intracellular studies in rat brain slices. Synapse (New York, N.Y.). 1: 481-7. PMID 2463688 DOI: 10.1002/syn.890010512  1
1987 Aghajanian GK, Wang YY. Common alpha 2- and opiate effector mechanisms in the locus coeruleus: intracellular studies in brain slices. Neuropharmacology. 26: 793-9. PMID 2443865 DOI: 10.1016/0028-3908(87)90054-2  1
1986 Innis RB, Aghajanian GK. Cholecystokinin-containing and nociceptive neurons in rat Edinger-Westphal nucleus. Brain Research. 363: 230-8. PMID 3942895 DOI: 10.1016/0006-8993(86)91008-5  1
1986 Rasmussen K, Glennon RA, Aghajanian GK. Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2 binding affinity. European Journal of Pharmacology. 132: 79-82. PMID 3816969 DOI: 10.1016/0014-2999(86)90014-2  1
1986 Aghajanian GK, Wang YY. Pertussis toxin blocks the outward currents evoked by opiate and alpha 2-agonists in locus coeruleus neurons. Brain Research. 371: 390-4. PMID 3697768 DOI: 10.1016/0006-8993(86)90382-3  1
1986 Rasmussen K, Aghajanian GK. Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2 antagonists. Brain Research. 385: 395-400. PMID 3096493 DOI: 10.1016/0006-8993(86)91090-5  1
1986 Sprouse JS, Aghajanian GK. (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. European Journal of Pharmacology. 128: 295-8. PMID 2878817 DOI: 10.1016/0014-2999(86)90782-X  1
1985 Lakoski JM, Aghajanian GK. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24: 265-73. PMID 3158835 DOI: 10.1016/0028-3908(85)90130-3  1
1985 Freedman JE, Aghajanian GK. Opiate and alpha 2-adrenoceptor responses of rat amygdaloid neurons: co-localization and interactions during withdrawal. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 3016-24. PMID 2997411  1
1985 Andrade R, Aghajanian GK. Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 2359-64. PMID 2993542  1
1985 Innis RB, Aghajanian GK. Integrated anatomical and physiological studies of neuronal cholecystokinin receptors. Annals of the New York Academy of Sciences. 448: 188-97. PMID 2992344  1
1985 Innis RB, Andrade R, Aghajanian GK. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Research. 335: 381-3. PMID 2408703 DOI: 10.1016/0006-8993(85)90499-8  1
1984 Andrade R, Aghajanian GK. Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition. Brain Research. 310: 401-6. PMID 6488034 DOI: 10.1016/0006-8993(84)90170-7  1
1984 Aghajanian GK, Lakoski JM. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Research. 305: 181-5. PMID 6331598 DOI: 10.1016/0006-8993(84)91137-5  1
1984 Andrade R, Aghajanian GK. Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 161-70. PMID 6319626  1
1984 Freedman JE, Aghajanian GK. Idazoxan (RX 781094) selectively antagonizes alpha 2-adrenoceptors on rat central neurons. European Journal of Pharmacology. 105: 265-72. PMID 6150858 DOI: 10.1016/0014-2999(84)90618-6  1
1984 Lakoski JM, Gallager DW, Aghajanian GK. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. European Journal of Pharmacology. 103: 153-6. PMID 6148254 DOI: 10.1016/0014-2999(84)90202-4  1
1983 Andrade R, Vandermaelen CP, Aghajanian GK. Morphine tolerance and dependence in the locus coeruleus: single cell studies in brain slices. European Journal of Pharmacology. 91: 161-9. PMID 6684572 DOI: 10.1016/0014-2999(83)90461-2  1
1983 Aghajanian GK, Vandermaelen CP, Andrade R. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Research. 273: 237-43. PMID 6311349 DOI: 10.1016/0006-8993(83)90848-X  1
1983 Menkes DB, Gallager DW, Reinhard JF, Aghajanian GK. Alpha 1-adrenoceptor denervation supersensitivity in brain: physiological and receptor binding studies. Brain Research. 272: 1-12. PMID 6311335 DOI: 10.1016/0006-8993(83)90358-X  1
1983 Menkes DB, Kehne JH, Gallager DW, Aghajanian GK, Davis M. Functional supersensitivity of CNS alpha 1-adrenoceptors following chronic antidepressant treatment. Life Sciences. 33: 181-8. PMID 6306376 DOI: 10.1016/0024-3205(83)90411-3  1
1983 Menkes DB, Aghajanian GK, Gallager DW. Chronic antidepressant treatment enhances agonist affinity of brain alpha 1-adrenoceptors. European Journal of Pharmacology. 87: 35-41. PMID 6301854 DOI: 10.1016/0014-2999(83)90047-X  1
1983 Vandermaelen CP, Aghajanian GK. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Research. 289: 109-19. PMID 6140982 DOI: 10.1016/0006-8993(83)90011-2  1
1983 Lakoski JM, Aghajanian GK. Effects of histamine, H1- and H2-receptor antagonists on the activity of serotonergic neurons in the dorsal raphe nucleus. The Journal of Pharmacology and Experimental Therapeutics. 227: 517-23. PMID 6138428  1
1983 Lakoski JM, Aghajanian GK, Gallager DW. Interaction of histamine H2-receptor antagonists with GABA and benzodiazepine binding sites in the CNS. European Journal of Pharmacology. 88: 241-5. PMID 6133770 DOI: 10.1016/0014-2999(83)90011-0  1
1983 Aghajanian GK, Rogawski MA. The physiological role of α-adrenoceptors in the CNS: new concepts from single-cell studies Trends in Pharmacological Sciences. 4: 315-317. DOI: 10.1016/0165-6147(83)90417-0  1
1982 Aghajanian GK, Vandermaelen CP. Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 1786-92. PMID 7143052  1
1982 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: selective blockade by the alpha 1-adrenoceptor antagonist prazosin. Brain Research. 250: 31-9. PMID 7139319 DOI: 10.1016/0006-8993(82)90950-7  1
1982 Vandermaelen CP, Aghajanian GK. Intracellular studies on the effects of systemic administration of serotonin agonists on rat facial motoneurons. European Journal of Pharmacology. 78: 233-6. PMID 7075673 DOI: 10.1016/0014-2999(82)90242-4  1
1982 Aghajanian GK, Vandermaelen CP. Intracellular recording in vivo from serotonergic neurons in the rat dorsal raphe nucleus: methodological considerations. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 30: 813-4. PMID 6749973  1
1982 Aghajanian GK, Vandermaelen CP. Intracellular recordings from serotonergic dorsal raphe neurons: pacemaker potentials and the effect of LSD. Brain Research. 238: 463-9. PMID 6284300 DOI: 10.1016/0006-8993(82)90124-X  1
1982 Aghajanian GK, VanderMaelen CP. alpha 2-adrenoceptor-mediated hyperpolarization of locus coeruleus neurons: intracellular studies in vivo. Science (New York, N.Y.). 215: 1394-6. PMID 6278591  1
1982 Wang RY, Aghajanian GK. Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2: 11-6. PMID 6275047  1
1982 Marwaha J, Aghajanian GK. Typical and atypical neuroleptics are potent antagonists at alpha 1-adrenoceptors of the dorsal lateral geniculate nucleus. An electrophysiological study. Naunyn-Schmiedeberg's Archives of Pharmacology. 321: 32-7. PMID 6128681 DOI: 10.1007/BF00586345  1
1982 Andrade R, Aghajanian GK. Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Research. 242: 125-35. PMID 6125245 DOI: 10.1016/0006-8993(82)90502-9  1
1982 Marwaha J, Aghajanian GK. Relative potencies of alpha-1 and alpha-2 antagonists in the locus ceruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study. The Journal of Pharmacology and Experimental Therapeutics. 222: 287-93. PMID 6124632  1
1982 Vandermaelen CP, Aghajanian GK. Serotonin-induced depolarization of rat facial motoneurons in vivo: comparison with amino acid transmitters. Brain Research. 239: 139-52. PMID 6124300 DOI: 10.1016/0006-8993(82)90838-1  1
1981 Rogawski MA, Aghajanian GK. Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1148-54. PMID 6793698  1
1981 Menkes DB, Aghajanian GK. alpha 1-Adrenoceptor-mediated responses in the lateral geniculate nucleus are enhanced by chronic antidepressant treatment. European Journal of Pharmacology. 74: 27-35. PMID 6274648 DOI: 10.1016/0014-2999(81)90319-8  1
1981 Baraban JM, Aghajanian GK. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Research. 204: 1-11. PMID 6166350 DOI: 10.1016/0006-8993(81)90646-6  1
1981 Menkes DB, Baraban JM, Aghajanian GK. Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 317: 273-5. PMID 6119624 DOI: 10.1007/BF00503830  1
1980 Aghajanian GK, McCall RB. Serotonergic synaptic input to facial motoneurons: localization by electron-microscopic autoradiography. Neuroscience. 5: 2155-62. PMID 7465049 DOI: 10.1016/0306-4522(80)90132-3  1
1980 VanderMaelen CP, Aghajanian GK. Intracellular studies showing modulation of facial motoneurone excitability by serotonin. Nature. 287: 346-7. PMID 7421993 DOI: 10.1038/287346a0  1
1980 Rogawski MA, Aghajanian GK. Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Experimental Neurology. 69: 678-94. PMID 7409069  1
1980 McCall RB, Aghajanian GK. Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. European Journal of Pharmacology. 65: 175-83. PMID 7398786  1
1980 Wang RY, Aghajanian GK. Enhanced sensitivity of amygdaloid neurons to serotonin and norepinephrine after chronic antidepressant treatment. Communications in Psychopharmacology. 4: 83-90. PMID 7398246  1
1980 McCall RB, Aghajanian GK. Hallucinogens potentiate responses to serotonin and norepinephrine in the facial motor nucleus. Life Sciences. 26: 1149-56. PMID 7392793 DOI: 10.1016/0024-3205(80)90654-2  1
1980 De Montigny C, Wang RY, Reader TA, Aghajanian GK. Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Research. 200: 363-76. PMID 6968237 DOI: 10.1016/0006-8993(80)90927-0  1
1980 Rogawski MA, Aghajanian GK. Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulation. Nature. 287: 731-4. PMID 6253811 DOI: 10.1038/287731a0  1
1980 Menkes DB, Aghajanian GK, McCall RB. Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sciences. 27: 45-55. PMID 6249992 DOI: 10.1016/0024-3205(80)90018-1  1
1980 Baraban JM, Aghajanian GK. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: evidence against GABA mediation. European Journal of Pharmacology. 66: 287-94. PMID 6106551  1
1980 Baraban JM, Aghajanian GK. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology. 19: 355-63. PMID 6104308 DOI: 10.1016/0028-3908(80)90187-2  1
1980 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by norepinephrine: mediation by an alpha-adrenergic receptor. Brain Research. 182: 345-59. PMID 6101983 DOI: 10.1016/0006-8993(80)91193-2  1
1979 Wang RY, de Montigny C, Gold BI, Roth RH, Aghajanian GK. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain Research. 178: 479-97. PMID 509215 DOI: 10.1016/0006-8993(79)90708-X  1
1979 Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Delayed iontophoretic ejection of substance P from glass micropipettes: correlation with time-course of neuronal excitation in vivo. Neuropharmacology. 18: 553-8. PMID 481708 DOI: 10.1016/0028-3908(79)90100-X  1
1979 Rogawski MA, Aghajanian GK. Response of central monoaminergic neurons to lisuride: comparison with LSD. Life Sciences. 24: 1289-97. PMID 470543 DOI: 10.1016/0024-3205(79)90148-6  1
1979 McCall RB, Aghajanian GK. Denervation supersensitivity to serotonin in the facial nucleus. Neuroscience. 4: 1501-10. PMID 317926 DOI: 10.1016/0306-4522(79)90055-1  1
1979 Rogawski MA, Roth RH, Aghajanian GK. Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase. Journal of Neurochemistry. 32: 1219-26. PMID 285213 DOI: 10.1111/j.1471-4159.1979.tb11049.x  1
1979 Guyenet PG, Aghajanian GK. ACh, substance P and met-enkephalin in the locus coeruleus: pharmacological evidence for independent sites of action. European Journal of Pharmacology. 53: 319-28. PMID 217695 DOI: 10.1016/0014-2999(79)90455-2  1
1979 McCall RB, Aghajanian GK. Serotonergic facilitation of facial motoneuron excitation. Brain Research. 169: 11-27. PMID 156574 DOI: 10.1016/0006-8993(79)90370-6  1
1978 de Montigny C, Aghajanian GK. Tricyclic antidepressants: long-term treatment increases responsivity of rat forebrain neurons to serotonin. Science (New York, N.Y.). 202: 1303-6. PMID 725608  1
1978 Bunney BS, Aghajanian GK. d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. 304: 255-61. PMID 714182 DOI: 10.1007/BF00507966  1
1978 Aghajanian GK, Wang RY, Baraban J. Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation. Brain Research. 153: 169-75. PMID 679043 DOI: 10.1016/0006-8993(78)91140-X  1
1978 Cedarbaum JM, Aghajanian GK. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal of Comparative Neurology. 178: 1-16. PMID 632368 DOI: 10.1002/cne.901780102  1
1978 Cedarbaum JM, Aghajanian GK. Activation of locus coeruleus neurons by peripheral stimuli: modulation by a collateral inhibitory mechanism. Life Sciences. 23: 1383-92. PMID 214648 DOI: 10.1016/0024-3205(78)90398-3  1
1978 Baraban JM, Wang RY, Aghajanian G. Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system. European Journal of Pharmacology. 52: 27-36. PMID 214312 DOI: 10.1016/0014-2999(78)90018-3  1
1978 Wang RY, Aghajanian GK. Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: pharmacological evidence. Neuropharmacology. 17: 819-25. PMID 154620 DOI: 10.1016/0028-3908(78)90070-9  1
1978 Guyenet PG, Aghajanian GK. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Research. 150: 69-84. PMID 78748 DOI: 10.1016/0006-8993(78)90654-6  1
1977 Aghajanian GK, Cedarbaum JM, Wang RY. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Research. 136: 570-7. PMID 922502 DOI: 10.1016/0006-8993(77)90083-X  1
1977 Wang RY, Aghajanian GK. Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition. Brain Research. 132: 186-93. PMID 890477  1
1977 Bunney BS, Aghajanian GK. D-Amphetamine-induced inhibition of central dopaminergic neurons: direct effect or mediated by a striatonigral feedback pathway? Advances in Biochemical Psychopharmacology. 16: 577-82. PMID 883560  1
1977 Aghajanian GK, Bunney BS. Pharmacological characterization of dopamine "autoreceptors" by microiontophoretic single-cell recording studies. Advances in Biochemical Psychopharmacology. 16: 433-8. PMID 883551  1
1977 Davis M, Gallager DW, Aghajanian GK. Tricyclic antidepressant drugs: Attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response Life Sciences. 20: 1249-1257. PMID 850475 DOI: 10.1016/0024-3205(77)90499-4  1
1977 Aghajanian GK, Wang RY. Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique. Brain Research. 122: 229-42. PMID 837230 DOI: 10.1016/0006-8993(77)90291-8  1
1977 Guyenet PG, Aghajanian GK. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Research. 136: 178-84. PMID 412562 DOI: 10.1016/0006-8993(77)90144-5  1
1977 Davis M, Cedarbaum JM, Aghajanian GK, Gendelman DS. Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. Psychopharmacology. 51: 243-53. PMID 403539 DOI: 10.1007/BF00431631  1
1977 Cedarbaum JM, Aghajanian GK. Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. European Journal of Pharmacology. 44: 375-85. PMID 330174 DOI: 10.1016/0014-2999(77)90312-0  1
1977 Bunney BS, Aghajanian GK. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances in Biochemical Psychopharmacology. 16: 65-70. PMID 329653  1
1977 Haigler HJ, Aghajanian GK. Serotonin receptors in the brain. Federation Proceedings. 36: 2159-64. PMID 326580  1
1977 Wang RY, Aghajanian GK. Physiological evidence for habenula as major link between forebrain and midbrain raphe. Science (New York, N.Y.). 197: 89-91. PMID 194312  1
1977 Aghajanian GK, Bunney BS. Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 297: 1-7. PMID 193046 DOI: 10.1007/BF00508803  1
1977 Wang RY, Aghajanian GK. Inhibiton of neurons in the amygdala by dorsal raphe stimulation: mediation through a direct serotonergic pathway. Brain Research. 120: 85-102. PMID 137766 DOI: 10.1016/0006-8993(77)90499-1  1
1977 Wang RY, Aghajanian GK. Recording of single unit activity during electrical stimulation and microiontophoresis: a method of minimizing stimulus artifacts. Electroencephalography and Clinical Neurophysiology. 43: 434-7. PMID 70345 DOI: 10.1016/0013-4694(77)90267-X  1
1976 Bunney BS, Achajanian GK. d-Amphetamine-induced inhibition of central dopaminergic neurons: mediation by a striato-nigral feedback pathway. Science (New York, N.Y.). 192: 391-3. PMID 1257777  1
1976 Gallager DW, Aghajanian GK. Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602. Neuropharmacology. 15: 149-56. PMID 1084488 DOI: 10.1016/0028-3908(76)90023-X  0.48
1976 Bunney BS, Aghajanian GK. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques. Life Sciences. 19: 1783-9. PMID 1004134 DOI: 10.1016/0024-3205(76)90087-4  1
1976 Bunney BS, Aghajanian GK. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research. 117: 423-35. PMID 990939 DOI: 10.1016/0006-8993(76)90751-4  1
1976 Bunney BS, Aghajanian GK. Dopaminergic infllence in the basal ganglia: evidence for striatonigral feedback regulation. Research Publications - Association For Research in Nervous and Mental Disease. 55: 249-67. PMID 826996  1
1976 Davis M, Aghajanian GK. Effects of apomorphine and haloperidol on the acoustic startle response in rats. Psychopharmacology. 47: 217-23. PMID 823557 DOI: 10.1007/BF00427605  0.48
1976 Wang RY, Gallager DW, Aghajanian GK. Stimulation of pontine reticular formation suppresses firing of serotonergic neuronses in the dorsal raphe. Nature. 264: 365-8. PMID 187951  1
1976 Gallager DW, Aghajanian GK. Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. European Journal of Pharmacology. 39: 357-64. PMID 10174 DOI: 10.1016/0014-2999(76)90145-X  0.48
1976 Gallager DW, Aghajanian GK. Effect of antipsychotic drugs on the firing of dorsal raphe cells. I. Role of adrenergic system. European Journal of Pharmacology. 39: 341-55. PMID 10173 DOI: 10.1016/0014-2999(76)90144-8  0.48
1976 Cedarbaum JM, Aghajanian GK. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Research. 112: 413-9. PMID 8191 DOI: 10.1016/0006-8993(76)90297-3  1
1975 Bunney BS, Roth RH, Aghajanian GK. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications. 1: 349-58. PMID 1224004  1
1975 Bunney BS, Walters JR, Kuhar MJ, Roth RH, Aghajanian GK. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications. 1: 177-90. PMID 1223998  1
1975 Svensson TH, Bunney BS, Aghajanian GK. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Research. 92: 291-306. PMID 1174954 DOI: 10.1016/0006-8993(75)90276-0  1
1975 Davis M, Svensson TH, Aghajanian GK. Effects of d- and l-amphetamine on habituation and sensitization of the acoustic startle response in rats. Psychopharmacologia. 43: 1-11. PMID 1172255  0.56
1975 Nybäck HV, Walters JR, Aghajanian GK, Roth RH. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. European Journal of Pharmacology. 32: 302-12. PMID 1149813  1
1975 Aghajanian GK, Davis M. A method of direct chemical brain stimulation in behavioral studies using microiontophoresis. Pharmacology, Biochemistry, and Behavior. 3: 127-31. PMID 1129349 DOI: 10.1016/0091-3057(75)90091-X  0.48
1975 Gallager DW, Sanders-Bush E, Aghajanian GK, Sulser F. An evaluation of the use of intraventricularly administered [3H]5-hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine. Brain Research. 93: 111-22. PMID 1040550 DOI: 10.1016/0006-8993(75)90289-9  1
1975 Gallager DW, Aghajanian GK. Effects of chlorimipramine and lysergic acid diethylamide on efflux of precursor-formed 3-H-serotonin: correlations with serotonergic impulse flow. The Journal of Pharmacology and Experimental Therapeutics. 193: 785-95. PMID 168347  0.48
1975 Aghajanian GK, Gallager DW. Raphe origin of serotonergic nerves terminating in the cerebral ventricles. Brain Research. 88: 221-31. PMID 167906 DOI: 10.1016/0006-8993(75)90386-8  0.48
1975 Bunney BS, Aghajanian GK. Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS. Psychopharmacology Bulletin. 11: 8-10. PMID 724  1
1975 Aghajanian GK, Bunney BS. Dopaminergic and non dopaminergic neurons of the substantia nigra: differential responses to putative transmitters | NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974 Excerpta Medica. 444-452.  1
1974 Kuhar MJ, Aghajanian GK, Roth RH. Serotonin neurons: a synaptic mechanism for the reuptake of serotonin. Advances in Biochemical Psychopharmacology. 10: 287-95. PMID 4846544  1
1974 Bunney BS, Aghajanian GK. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences. 15: 309-18. PMID 4549921 DOI: 10.1016/0024-3205(74)90221-5  1
1974 Bunney BS, Aghajanian GK. Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons. Psychopharmacology Bulletin. 10: 17-8. PMID 4473793  1
1974 Korf J, Bunney BS, Aghajanian GK. Noradrenergic neurons: morphine inhibition of spontaneous activity. European Journal of Pharmacology. 25: 165-9. PMID 4435020 DOI: 10.1016/0014-2999(74)90045-4  1
1974 Asher IM, Aghajanian GK. 6-Hydroxydopamine lesions of olfactory tubercles and caudate nuclei: effect on amphetamine-induced stereotyped behavior in rats. Brain Research. 82: 1-12. PMID 4373138 DOI: 10.1016/0006-8993(74)90888-9  1
1974 Bennett JL, Aghajanian GK. The effect of p-chlorophenylalanine on forebrain tryptophan hydroxylase in rats with lesions in the raphe nucleus. Brain Research. 65: 537-41. PMID 4278311 DOI: 10.1016/0006-8993(74)90245-5  0.01
1974 Bunney BS, Aghajanian GK. Antipsychotic drugs and amphetamine: Direct evidence for an action of dopaminergic neurons Journal of Psychiatric Research. 10: 150. DOI: 10.1016/0022-3956(74)90036-3  1
1974 Bunney BS, Aghajanian GK. Electrophysiological effects of amphetamine on dopaminergic neurons Biochemical Pharmacology. 23: 792-797. DOI: 10.1016/0006-2952(74)90134-8  1
1974 Aghajanian GK, Bunney BS. Central dopaminergic neurons: Neurophysiological identification and responses to drugs Biochemical Pharmacology. 23: 523-528. DOI: 10.1016/0006-2952(74)90074-4  1
1973 Korf J, Aghajanian GK, Roth RH. Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus. Neuropharmacology. 12: 933-8. PMID 4750561 DOI: 10.1016/0028-3908(73)90024-5  1
1973 Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. The Journal of Pharmacology and Experimental Therapeutics. 186: 630-9. PMID 4728341  1
1973 Korf J, Aghajanian GK, Roth RH. Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex. European Journal of Pharmacology. 21: 305-10. PMID 4708068  1
1973 Kuhar MJ, Sethy VH, Roth RH, Aghajanian GK. Choline: selective accumulation by central cholinergic neurons. Journal of Neurochemistry. 20: 581-93. PMID 4698301  1
1973 Korf J, Roth RH, Aghajanian GK. Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways. European Journal of Pharmacology. 23: 276-82. PMID 4583563 DOI: 10.1016/0014-2999(73)90095-2  1
1973 Bunney BS, Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. The Journal of Pharmacology and Experimental Therapeutics. 185: 560-71. PMID 4576427  1
1973 Bunney BS, Aghajanian GK, Roth RH. Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature: New Biology. 245: 123-5. PMID 4518113  1
1973 Kuhar MJ, Aghajanian GK. Selective accumulation of 3 H-serotonin by nerve terminals of raphe neurones: an autoradiographic study. Nature: New Biology. 241: 187-9. PMID 4512580  0.76
1973 Sethy VH, Kuhar MJ, Roth RH, Van Woert MH, Aghajanian GK. Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampus. Brain Research. 55: 481-4. PMID 4351629  1
1973 Aghajanian GK, Kuhar MJ, Roth RH. Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine. Brain Research. 54: 85-101. PMID 4267802  1
1972 Touloukian RJ, Aghajanian GK, Roth RH. Adrenergic denervation of the hypertrophied gut remnant. Annals of Surgery. 176: 633-7. PMID 5079824  1
1972 Kuhar MJ, Aghajanian GK, Roth RH. Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence. Brain Research. 44: 165-76. PMID 5056975  1
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synthesis of catecholamines in the locus coeruleus from 3 H-tyrosine in vivo. Biochemical Pharmacology. 21: 2280-2. PMID 4646193  1
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. The Journal of Pharmacology and Experimental Therapeutics. 181: 36-45. PMID 4552069  1
1971 Kuhar MJ, Roth RH, Aghajanian GK. Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Research. 35: 167-76. PMID 4257335  1
1970 Aghajanian GK, Roth RH. Gamma-hydroxybutyrate-induced increase in brain dopamine: localization by fluorescence microscopy. The Journal of Pharmacology and Experimental Therapeutics. 175: 131-8. PMID 5471444  1
1966 Freedman DX, Aghajanian GK. Approaches to the pharmacology of LSD-25 Lloydia. 29: 309-314.  1
1958 FREEDMAN DX, AGHAJANIAN GK, ORNITZ EM. Patterns of tolerance to lysergic acid diethylamide and mescaline in rats. Science (New York, N.Y.). 127: 1173-4. PMID 13555858  1
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