Year |
Citation |
Score |
2016 |
Liu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS. GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27634355 DOI: 10.1038/Npp.2016.202 |
0.336 |
|
2015 |
Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America. 112: 8106-11. PMID 26056286 DOI: 10.1073/Pnas.1414728112 |
0.305 |
|
2015 |
Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK. Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2066-75. PMID 25759300 DOI: 10.1038/Npp.2015.70 |
0.307 |
|
2014 |
Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine. 20: 531-5. PMID 24728411 DOI: 10.1038/Nm.3513 |
0.306 |
|
2014 |
Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience. 17: 248-53. PMID 24441680 DOI: 10.1038/Nn.3625 |
0.307 |
|
2014 |
Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 233. PMID 24317309 DOI: 10.1038/npp.2013.217 |
0.309 |
|
2013 |
Voleti B, Navarria A, Liu RJ, Banasr M, Li N, Terwilliger R, Sanacora G, Eid T, Aghajanian G, Duman RS. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biological Psychiatry. 74: 742-9. PMID 23751205 DOI: 10.1016/J.Biopsych.2013.04.025 |
0.325 |
|
2013 |
Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK. GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2268-77. PMID 23680942 DOI: 10.1038/Npp.2013.128 |
0.306 |
|
2012 |
Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science (New York, N.Y.). 338: 68-72. PMID 23042884 DOI: 10.1126/science.1222939 |
0.321 |
|
2012 |
Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological Psychiatry. 71: 996-1005. PMID 22036038 DOI: 10.1016/J.Biopsych.2011.09.030 |
0.301 |
|
2012 |
Duman RS, Li N, Liu RJ, Duric V, Aghajanian G. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology. 62: 35-41. PMID 21907221 DOI: 10.1016/J.Neuropharm.2011.08.044 |
0.31 |
|
2011 |
Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biological Psychiatry. 69: 754-61. PMID 21292242 DOI: 10.1016/J.Biopsych.2010.12.015 |
0.317 |
|
2010 |
Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science (New York, N.Y.). 329: 959-64. PMID 20724638 DOI: 10.1126/Science.1190287 |
0.311 |
|
2010 |
Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8263-73. PMID 20554878 DOI: 10.1523/Jneurosci.5858-09.2010 |
0.305 |
|
2007 |
Lambe EK, Liu RJ, Aghajanian GK. Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophrenia Bulletin. 33: 1284-90. PMID 17656637 DOI: 10.1093/schbul/sbm088 |
0.644 |
|
2007 |
Lambe EK, Aghajanian GK. Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation. Neuroscience. 145: 900-10. PMID 17293055 DOI: 10.1016/j.neuroscience.2006.12.048 |
0.649 |
|
2007 |
Heninger GR, Krystal JH, Duman RS, Bunney BS, Bowers MB, Aghajanian GK. The Neuroscience Research Program at the Connecticut Mental Health Center 40 Years of Academic Public Psychiatry. 77-95. DOI: 10.1002/9780470994580.ch4 |
0.497 |
|
2006 |
Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, et al. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (New York, N.Y.). 313: 536-40. PMID 16873667 DOI: 10.1126/Science.1123432 |
0.642 |
|
2006 |
Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4624-9. PMID 16641242 DOI: 10.1523/Jneurosci.4701-05.2006 |
0.309 |
|
2006 |
Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of Neurobiology. 66: 408-20. PMID 16408297 DOI: 10.1002/Neu.20233 |
0.655 |
|
2006 |
Lambe EK, Aghajanian GK. Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1682-9. PMID 16292328 DOI: 10.1038/sj.npp.1300944 |
0.65 |
|
2005 |
Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5225-9. PMID 15917462 DOI: 10.1523/JNEUROSCI.0719-05.2005 |
0.638 |
|
2005 |
Liu RJ, Lambe EK, Aghajanian GK. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. The European Journal of Neuroscience. 21: 945-58. PMID 15787701 DOI: 10.1111/j.1460-9568.2005.03930.x |
0.648 |
|
2005 |
Lambe EK, Aghajanian GK. Effects of hypocretin/orexin on the thalamocortical activating system Hypocretins: Integrators of Physiological Functions. 191-202. DOI: 10.1007/0-387-25446-3_12 |
0.597 |
|
2003 |
Lambe EK, Aghajanian GK. Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron. 40: 139-50. PMID 14527439 DOI: 10.1016/S0896-6273(03)00598-1 |
0.644 |
|
2003 |
Lambe EK, Picciotto MR, Aghajanian GK. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 216-25. PMID 12589374 DOI: 10.1038/sj.npp.1300032 |
0.648 |
|
2003 |
Aghajanian G, Bunney BS, Holzman PS. Patricia Goldman-Rakic, 1937–2003 Neuropsychopharmacology. 28: 2218-2220. DOI: 10.1038/sj.npp.1300325 |
0.566 |
|
2002 |
Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4153-62. PMID 12019333 DOI: 10.1523/Jneurosci.22-10-04153.2002 |
0.303 |
|
2002 |
van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB. Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. The Journal of Physiology. 541: 169-85. PMID 12015428 DOI: 10.1113/jphysiol.2002.017426 |
0.31 |
|
2001 |
Lambe EK, Aghajanian GK. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9955-63. PMID 11739602 DOI: 10.1523/Jneurosci.21-24-09955.2001 |
0.659 |
|
2001 |
Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, ... Aghajanian GK, et al. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry. 6: 593-604. PMID 11526474 DOI: 10.1038/Sj.Mp.4000897 |
0.306 |
|
2000 |
Lambe EK, Goldman-Rakic PS, Aghajanian GK. Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. Cerebral Cortex (New York, N.Y. : 1991). 10: 974-80. PMID 11007548 DOI: 10.1093/cercor/10.10.974 |
0.716 |
|
1999 |
Schoepp DD, Monn JA, Marek GJ, Aghajanian G, Moghaddam B. LY354740: A systemically active mGlu2/mGlu3 receptor agonist Cns Drug Reviews. 5: 1-12. DOI: 10.1111/J.1527-3458.1999.Tb00082.X |
0.483 |
|
1999 |
Krystal JH, Belger A, D'Souza DC, Anand A, Charney DS, Aghajanian GK, Moghaddam B. Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists Neuropsychopharmacology. 21: S143-S157. DOI: 10.1016/S0893-133X(99)00102-5 |
0.558 |
|
1996 |
Rasmussen K, Kendrick WT, Kogan JH, Aghajanian GK. A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 497-505. PMID 8914123 DOI: 10.1016/S0893-133X(96)00094-2 |
0.504 |
|
1996 |
Pineda J, Kogan JH, Aghajanian GK. Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 1389-99. PMID 8778290 DOI: 10.1523/Jneurosci.16-04-01389.1996 |
0.308 |
|
1995 |
Kogan JH, Aghajanian GK. Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal. Brain Research. 689: 111-21. PMID 8528694 DOI: 10.1016/0006-8993(95)00545-2 |
0.314 |
|
1994 |
Iyer RN, Sprouse JS, Aghajanian GK, Roth RH, Bradberry CW. Tryptophan pretreatment augmentation of p-chloroamphetamine-induced serotonin and dopamine release and reduction of long-term neurotoxicity. Biochemical Pharmacology. 48: 1501-8. PMID 7945451 DOI: 10.1016/0006-2952(94)90576-2 |
0.459 |
|
1994 |
Aghajanian GK, Kogan JH, Moghaddam B. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Research. 636: 126-30. PMID 7908850 DOI: 10.1016/0006-8993(94)90186-4 |
0.551 |
|
1992 |
Kogan JH, Nestler EJ, Aghajanian GK. Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. European Journal of Pharmacology. 211: 47-53. PMID 1618268 DOI: 10.1016/0014-2999(92)90261-2 |
0.32 |
|
1991 |
Rasmussen K, Krystal JH, Aghajanian GK. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology. 105: 508-12. PMID 1771218 DOI: 10.1007/Bf02244371 |
0.464 |
|
1991 |
Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. Sub-picogram determination of serotonin using HPLC with electrochemical detection for microdialysis studies of serotonin release. Advances in Experimental Medicine and Biology. 294: 81-9. PMID 1685295 DOI: 10.1007/978-1-4684-5952-4_7 |
0.459 |
|
1991 |
Bradberry CW, Sprouse JS, Sheldon PW, Aghajanian GK, Roth RH. In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements. Journal of Neuroscience Methods. 36: 85-90. PMID 1676433 DOI: 10.1016/0165-0270(91)90141-L |
0.459 |
|
1991 |
Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research. 4: 121-56. PMID 1674882 DOI: 10.1016/0920-9964(91)90030-U |
0.682 |
|
1990 |
Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. 3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan. Neurochemistry International. 17: 509-13. PMID 20504652 DOI: 10.1016/0197-0186(90)90037-T |
0.459 |
|
1990 |
Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse (New York, N.Y.). 5: 324-32. PMID 2360199 DOI: 10.1002/Syn.890050409 |
0.464 |
|
1990 |
Aghajanian GK, Sprouse JS, Sheldon P, Rasmussen K. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Annals of the New York Academy of Sciences. 600: 93-103; discussion 1. PMID 2123618 DOI: 10.1111/J.1749-6632.1990.Tb16875.X |
0.464 |
|
1990 |
Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2308-17. PMID 2115910 DOI: 10.1523/Jneurosci.10-07-02308.1990 |
0.464 |
|
1990 |
Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. European Journal of Pharmacology. 178: 313-20. PMID 1971220 DOI: 10.1016/0014-2999(90)90110-R |
0.459 |
|
1989 |
Rasmussen K, Aghajanian GK. Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei. Synapse (New York, N.Y.). 4: 162-4. PMID 2781467 DOI: 10.1002/Syn.890040210 |
0.464 |
|
1989 |
Aghajanian GK, Rasmussen K. Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse (New York, N.Y.). 3: 331-8. PMID 2740992 DOI: 10.1002/Syn.890030406 |
0.464 |
|
1989 |
Rasmussen K, Aghajanian GK. Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Research. 505: 346-50. PMID 2598056 DOI: 10.1016/0006-8993(89)91466-2 |
0.464 |
|
1989 |
Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin. European Journal of Pharmacology. 167: 375-83. PMID 2572435 DOI: 10.1016/0014-2999(89)90446-9 |
0.459 |
|
1988 |
Innis RB, Nestler EJ, Aghajanian GK. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Research. 459: 27-36. PMID 3139262 DOI: 10.1016/0006-8993(88)90282-X |
0.333 |
|
1988 |
Rasmussen K, Aghajanian GK. Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 1: 101-7. PMID 2908015 DOI: 10.1016/0893-133X(88)90001-2 |
0.391 |
|
1987 |
Innis RB, Aghajanian GK. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Research. 411: 139-43. PMID 2955848 DOI: 10.1016/0006-8993(87)90690-1 |
0.308 |
|
1987 |
Innis RB, Aghajanian GK. Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. European Journal of Pharmacology. 143: 195-204. PMID 2826189 DOI: 10.1016/0014-2999(87)90533-4 |
0.342 |
|
1986 |
Innis RB, Aghajanian GK. Cholecystokinin-containing and nociceptive neurons in rat Edinger-Westphal nucleus. Brain Research. 363: 230-8. PMID 3942895 DOI: 10.1016/0006-8993(86)91008-5 |
0.31 |
|
1986 |
Rasmussen K, Glennon RA, Aghajanian GK. Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2 binding affinity. European Journal of Pharmacology. 132: 79-82. PMID 3816969 DOI: 10.1016/0014-2999(86)90014-2 |
0.491 |
|
1986 |
Rasmussen K, Aghajanian GK. Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2 antagonists. Brain Research. 385: 395-400. PMID 3096493 DOI: 10.1016/0006-8993(86)91090-5 |
0.464 |
|
1985 |
Lakoski JM, Aghajanian GK. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24: 265-73. PMID 3158835 DOI: 10.1016/0028-3908(85)90130-3 |
0.335 |
|
1985 |
Andrade R, Aghajanian GK. Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 2359-64. PMID 2993542 DOI: 10.1523/Jneurosci.05-09-02359.1985 |
0.472 |
|
1985 |
Innis RB, Aghajanian GK. Integrated anatomical and physiological studies of neuronal cholecystokinin receptors. Annals of the New York Academy of Sciences. 448: 188-97. PMID 2992344 DOI: 10.1111/J.1749-6632.1985.Tb29918.X |
0.301 |
|
1985 |
Innis RB, Andrade R, Aghajanian GK. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Research. 335: 381-3. PMID 2408703 DOI: 10.1016/0006-8993(85)90499-8 |
0.498 |
|
1984 |
Andrade R, Aghajanian GK. Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition. Brain Research. 310: 401-6. PMID 6488034 DOI: 10.1016/0006-8993(84)90170-7 |
0.472 |
|
1984 |
Aghajanian GK, Lakoski JM. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Research. 305: 181-5. PMID 6331598 DOI: 10.1016/0006-8993(84)91137-5 |
0.324 |
|
1984 |
Andrade R, Aghajanian GK. Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 161-70. PMID 6319626 DOI: 10.1523/Jneurosci.04-01-00161.1984 |
0.472 |
|
1984 |
Lakoski JM, Gallager DW, Aghajanian GK. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. European Journal of Pharmacology. 103: 153-6. PMID 6148254 DOI: 10.1016/0014-2999(84)90202-4 |
0.317 |
|
1983 |
Andrade R, Vandermaelen CP, Aghajanian GK. Morphine tolerance and dependence in the locus coeruleus: single cell studies in brain slices. European Journal of Pharmacology. 91: 161-9. PMID 6684572 DOI: 10.1016/0014-2999(83)90461-2 |
0.472 |
|
1983 |
Aghajanian GK, Vandermaelen CP, Andrade R. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Research. 273: 237-43. PMID 6311349 DOI: 10.1016/0006-8993(83)90848-X |
0.472 |
|
1983 |
Aghajanian GK, Rogawski MA. The physiological role of α-adrenoceptors in the CNS: new concepts from single-cell studies Trends in Pharmacological Sciences. 4: 315-317. DOI: 10.1016/0165-6147(83)90417-0 |
0.506 |
|
1982 |
Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: selective blockade by the alpha 1-adrenoceptor antagonist prazosin. Brain Research. 250: 31-9. PMID 7139319 DOI: 10.1016/0006-8993(82)90950-7 |
0.548 |
|
1982 |
Andrade R, Aghajanian GK. Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Research. 242: 125-35. PMID 6125245 DOI: 10.1016/0006-8993(82)90502-9 |
0.472 |
|
1981 |
Rogawski MA, Aghajanian GK. Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1148-54. PMID 6793698 DOI: 10.1523/Jneurosci.01-10-01148.1981 |
0.537 |
|
1981 |
Baraban JM, Aghajanian GK. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Research. 204: 1-11. PMID 6166350 DOI: 10.1016/0006-8993(81)90646-6 |
0.553 |
|
1981 |
Menkes DB, Baraban JM, Aghajanian GK. Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 317: 273-5. PMID 6119624 DOI: 10.1007/BF00503830 |
0.553 |
|
1980 |
Rogawski MA, Aghajanian GK. Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Experimental Neurology. 69: 678-94. PMID 7409069 DOI: 10.1016/0014-4886(80)90060-6 |
0.551 |
|
1980 |
McCall RB, Aghajanian GK. Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. European Journal of Pharmacology. 65: 175-83. PMID 7398786 DOI: 10.1016/0014-2999(80)90390-8 |
0.311 |
|
1980 |
McCall RB, Aghajanian GK. Hallucinogens potentiate responses to serotonin and norepinephrine in the facial motor nucleus. Life Sciences. 26: 1149-56. PMID 7392793 DOI: 10.1016/0024-3205(80)90654-2 |
0.32 |
|
1980 |
De Montigny C, Wang RY, Reader TA, Aghajanian GK. Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Research. 200: 363-76. PMID 6968237 DOI: 10.1016/0006-8993(80)90927-0 |
0.333 |
|
1980 |
Rogawski MA, Aghajanian GK. Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulation. Nature. 287: 731-4. PMID 6253811 DOI: 10.1038/287731a0 |
0.546 |
|
1980 |
Menkes DB, Aghajanian GK, McCall RB. Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sciences. 27: 45-55. PMID 6249992 DOI: 10.1016/0024-3205(80)90018-1 |
0.317 |
|
1980 |
Baraban JM, Aghajanian GK. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: evidence against GABA mediation. European Journal of Pharmacology. 66: 287-94. PMID 6106551 DOI: 10.1016/0014-2999(80)90461-6 |
0.553 |
|
1980 |
Baraban JM, Aghajanian GK. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology. 19: 355-63. PMID 6104308 DOI: 10.1016/0028-3908(80)90187-2 |
0.553 |
|
1980 |
Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by norepinephrine: mediation by an alpha-adrenergic receptor. Brain Research. 182: 345-59. PMID 6101983 DOI: 10.1016/0006-8993(80)91193-2 |
0.537 |
|
1979 |
Wang RY, de Montigny C, Gold BI, Roth RH, Aghajanian GK. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain Research. 178: 479-97. PMID 509215 DOI: 10.1016/0006-8993(79)90708-X |
0.459 |
|
1979 |
Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Delayed iontophoretic ejection of substance P from glass micropipettes: correlation with time-course of neuronal excitation in vivo. Neuropharmacology. 18: 553-8. PMID 481708 DOI: 10.1016/0028-3908(79)90100-X |
0.513 |
|
1979 |
Rogawski MA, Aghajanian GK. Response of central monoaminergic neurons to lisuride: comparison with LSD. Life Sciences. 24: 1289-97. PMID 470543 DOI: 10.1016/0024-3205(79)90148-6 |
0.544 |
|
1979 |
McCall RB, Aghajanian GK. Denervation supersensitivity to serotonin in the facial nucleus. Neuroscience. 4: 1501-10. PMID 317926 DOI: 10.1016/0306-4522(79)90055-1 |
0.313 |
|
1979 |
Rogawski MA, Roth RH, Aghajanian GK. Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase. Journal of Neurochemistry. 32: 1219-26. PMID 285213 DOI: 10.1111/j.1471-4159.1979.tb11049.x |
0.597 |
|
1979 |
Guyenet PG, Aghajanian GK. ACh, substance P and met-enkephalin in the locus coeruleus: pharmacological evidence for independent sites of action. European Journal of Pharmacology. 53: 319-28. PMID 217695 DOI: 10.1016/0014-2999(79)90455-2 |
0.513 |
|
1978 |
Bunney BS, Aghajanian GK. d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. 304: 255-61. PMID 714182 DOI: 10.1007/BF00507966 |
0.566 |
|
1978 |
Aghajanian GK, Wang RY, Baraban J. Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation. Brain Research. 153: 169-75. PMID 679043 DOI: 10.1016/0006-8993(78)91140-X |
0.553 |
|
1978 |
Cedarbaum JM, Aghajanian GK. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal of Comparative Neurology. 178: 1-16. PMID 632368 DOI: 10.1002/Cne.901780102 |
0.563 |
|
1978 |
Cedarbaum JM, Aghajanian GK. Activation of locus coeruleus neurons by peripheral stimuli: modulation by a collateral inhibitory mechanism. Life Sciences. 23: 1383-92. PMID 214648 DOI: 10.1016/0024-3205(78)90398-3 |
0.563 |
|
1978 |
Baraban JM, Wang RY, Aghajanian G. Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system. European Journal of Pharmacology. 52: 27-36. PMID 214312 DOI: 10.1016/0014-2999(78)90018-3 |
0.553 |
|
1978 |
Guyenet PG, Aghajanian GK. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Research. 150: 69-84. PMID 78748 DOI: 10.1016/0006-8993(78)90654-6 |
0.513 |
|
1977 |
Aghajanian GK, Cedarbaum JM, Wang RY. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Research. 136: 570-7. PMID 922502 DOI: 10.1016/0006-8993(77)90083-X |
0.563 |
|
1977 |
Bunney BS, Aghajanian GK. D-Amphetamine-induced inhibition of central dopaminergic neurons: direct effect or mediated by a striatonigral feedback pathway? Advances in Biochemical Psychopharmacology. 16: 577-82. PMID 883560 |
0.521 |
|
1977 |
Aghajanian GK, Bunney BS. Pharmacological characterization of dopamine "autoreceptors" by microiontophoretic single-cell recording studies. Advances in Biochemical Psychopharmacology. 16: 433-8. PMID 883551 |
0.521 |
|
1977 |
Davis M, Gallager DW, Aghajanian GK. Tricyclic antidepressant drugs: Attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response Life Sciences. 20: 1249-1257. PMID 850475 DOI: 10.1016/0024-3205(77)90499-4 |
0.313 |
|
1977 |
Guyenet PG, Aghajanian GK. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Research. 136: 178-84. PMID 412562 DOI: 10.1016/0006-8993(77)90144-5 |
0.513 |
|
1977 |
Davis M, Cedarbaum JM, Aghajanian GK, Gendelman DS. Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. Psychopharmacology. 51: 243-53. PMID 403539 DOI: 10.1007/Bf00431631 |
0.578 |
|
1977 |
Cedarbaum JM, Aghajanian GK. Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. European Journal of Pharmacology. 44: 375-85. PMID 330174 DOI: 10.1016/0014-2999(77)90312-0 |
0.563 |
|
1977 |
Bunney BS, Aghajanian GK. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances in Biochemical Psychopharmacology. 16: 65-70. PMID 329653 |
0.521 |
|
1977 |
Aghajanian GK, Bunney BS. Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 297: 1-7. PMID 193046 DOI: 10.1007/BF00508803 |
0.566 |
|
1976 |
Bunney BS, Aghajanian GK. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques. Life Sciences. 19: 1783-9. PMID 1004134 DOI: 10.1016/0024-3205(76)90087-4 |
0.566 |
|
1976 |
Bunney BS, Aghajanian GK. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research. 117: 423-35. PMID 990939 DOI: 10.1016/0006-8993(76)90751-4 |
0.566 |
|
1976 |
Bunney BS, Aghajanian GK. Dopaminergic infllence in the basal ganglia: evidence for striatonigral feedback regulation. Research Publications - Association For Research in Nervous and Mental Disease. 55: 249-67. PMID 826996 |
0.521 |
|
1976 |
Cedarbaum JM, Aghajanian GK. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Research. 112: 413-9. PMID 8191 DOI: 10.1016/0006-8993(76)90297-3 |
0.563 |
|
1975 |
Bunney BS, Roth RH, Aghajanian GK. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications. 1: 349-58. PMID 1224004 |
0.521 |
|
1975 |
Bunney BS, Walters JR, Kuhar MJ, Roth RH, Aghajanian GK. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications. 1: 177-90. PMID 1223998 |
0.689 |
|
1975 |
Svensson TH, Bunney BS, Aghajanian GK. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Research. 92: 291-306. PMID 1174954 DOI: 10.1016/0006-8993(75)90276-0 |
0.566 |
|
1975 |
Nybäck HV, Walters JR, Aghajanian GK, Roth RH. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. European Journal of Pharmacology. 32: 302-12. PMID 1149813 DOI: 10.1016/0014-2999(75)90297-6 |
0.584 |
|
1975 |
Bunney BS, Aghajanian GK. Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS. Psychopharmacology Bulletin. 11: 8-10. PMID 724 |
0.521 |
|
1975 |
Aghajanian GK, Bunney BS. Dopaminergic and non dopaminergic neurons of the substantia nigra: differential responses to putative transmitters | NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974 Excerpta Medica. 444-452. |
0.521 |
|
1974 |
Kuhar MJ, Aghajanian GK, Roth RH. Serotonin neurons: a synaptic mechanism for the reuptake of serotonin. Advances in Biochemical Psychopharmacology. 10: 287-95. PMID 4846544 |
0.43 |
|
1974 |
Bunney BS, Aghajanian GK. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences. 15: 309-18. PMID 4549921 DOI: 10.1016/0024-3205(74)90221-5 |
0.566 |
|
1974 |
Bunney BS, Aghajanian GK. Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons. Psychopharmacology Bulletin. 10: 17-8. PMID 4473793 |
0.521 |
|
1974 |
Korf J, Bunney BS, Aghajanian GK. Noradrenergic neurons: morphine inhibition of spontaneous activity. European Journal of Pharmacology. 25: 165-9. PMID 4435020 DOI: 10.1016/0014-2999(74)90045-4 |
0.566 |
|
1974 |
Bunney BS, Aghajanian GK. Antipsychotic drugs and amphetamine: Direct evidence for an action of dopaminergic neurons Journal of Psychiatric Research. 10: 150. DOI: 10.1016/0022-3956(74)90036-3 |
0.521 |
|
1974 |
Bunney BS, Aghajanian GK. Electrophysiological effects of amphetamine on dopaminergic neurons Biochemical Pharmacology. 23: 792-797. DOI: 10.1016/0006-2952(74)90134-8 |
0.566 |
|
1974 |
Aghajanian GK, Bunney BS. Central dopaminergic neurons: Neurophysiological identification and responses to drugs Biochemical Pharmacology. 23: 523-528. DOI: 10.1016/0006-2952(74)90074-4 |
0.566 |
|
1973 |
Korf J, Aghajanian GK, Roth RH. Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus. Neuropharmacology. 12: 933-8. PMID 4750561 DOI: 10.1016/0028-3908(73)90024-5 |
0.459 |
|
1973 |
Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. The Journal of Pharmacology and Experimental Therapeutics. 186: 630-9. PMID 4728341 |
0.543 |
|
1973 |
Korf J, Aghajanian GK, Roth RH. Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex. European Journal of Pharmacology. 21: 305-10. PMID 4708068 DOI: 10.1016/0014-2999(73)90131-3 |
0.459 |
|
1973 |
Touloukian RJ, Aghajanian G, Roth RH. Adrenergic hyperactivity of the aganglionic colon Journal of Pediatric Surgery. 8: 191-195. PMID 4698355 DOI: 10.1016/S0022-3468(73)80084-3 |
0.459 |
|
1973 |
Kuhar MJ, Sethy VH, Roth RH, Aghajanian GK. Choline: selective accumulation by central cholinergic neurons. Journal of Neurochemistry. 20: 581-93. PMID 4698301 DOI: 10.1111/J.1471-4159.1973.Tb12157.X |
0.492 |
|
1973 |
Korf J, Roth RH, Aghajanian GK. Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways. European Journal of Pharmacology. 23: 276-82. PMID 4583563 DOI: 10.1016/0014-2999(73)90095-2 |
0.459 |
|
1973 |
Bunney BS, Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. The Journal of Pharmacology and Experimental Therapeutics. 185: 560-71. PMID 4576427 |
0.675 |
|
1973 |
Bunney BS, Aghajanian GK, Roth RH. Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature: New Biology. 245: 123-5. PMID 4518113 DOI: 10.1038/Newbio245123A0 |
0.638 |
|
1973 |
Kuhar MJ, Aghajanian GK. Selective accumulation of 3 H-serotonin by nerve terminals of raphe neurones: an autoradiographic study. Nature: New Biology. 241: 187-9. PMID 4512580 DOI: 10.1038/Newbio241187A0 |
0.311 |
|
1973 |
Sethy VH, Kuhar MJ, Roth RH, Van Woert MH, Aghajanian GK. Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampus. Brain Research. 55: 481-4. PMID 4351629 DOI: 10.1016/0006-8993(73)90318-1 |
0.485 |
|
1973 |
Aghajanian GK, Kuhar MJ, Roth RH. Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine. Brain Research. 54: 85-101. PMID 4267802 DOI: 10.1016/0006-8993(73)90036-X |
0.5 |
|
1973 |
Roth RH, Walters JR, Aghajanian GK. Effect of impulse flow on the release and synthesis of dopamine in the striatum Life Sciences. 13: cxxxix-cxl. DOI: 10.1016/0024-3205(73)90387-1 |
0.584 |
|
1972 |
Touloukian RJ, Aghajanian GK, Roth RH. Adrenergic denervation of the hypertrophied gut remnant. Annals of Surgery. 176: 633-7. PMID 5079824 DOI: 10.1097/00000658-197211000-00009 |
0.459 |
|
1972 |
Kuhar MJ, Aghajanian GK, Roth RH. Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence. Brain Research. 44: 165-76. PMID 5056975 DOI: 10.1016/0006-8993(72)90372-1 |
0.493 |
|
1972 |
Kuhar MJ, Roth RH, Aghajanian GK. Synthesis of catecholamines in the locus coeruleus from 3 H-tyrosine in vivo. Biochemical Pharmacology. 21: 2280-2. PMID 4646193 DOI: 10.1016/0006-2952(72)90047-0 |
0.452 |
|
1972 |
Aghajanian GK, Haigler HJ, Bloom FE. Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. Life Sciences. Pt. 1: Physiology and Pharmacology. 11: 615-22. PMID 4570795 DOI: 10.1016/0024-3205(72)90153-1 |
0.331 |
|
1972 |
Kuhar MJ, Roth RH, Aghajanian GK. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. The Journal of Pharmacology and Experimental Therapeutics. 181: 36-45. PMID 4552069 |
0.408 |
|
1971 |
Kuhar MJ, Roth RH, Aghajanian GK. Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Research. 35: 167-76. PMID 4257335 DOI: 10.1016/0006-8993(71)90602-0 |
0.481 |
|
1971 |
Weiss BL, Aghajanian GK. Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons Brain Research. 26: 37-48. DOI: 10.1016/0006-8993(71)90540-3 |
0.327 |
|
1969 |
Aghajanian GK, Bloom FE, Sheard MH. Electron microscopy of degeneration within the serotonin pathway of rat brain. Brain Research. 13: 266-73. PMID 5772424 DOI: 10.1016/0006-8993(69)90286-8 |
0.301 |
|
1968 |
Aghajanian GK, Weiss BL. Block by LSD of the increase in brain serotonin turnover induced by elevated ambient temperature. Nature. 220: 795-6. PMID 5698754 DOI: 10.1038/220795a0 |
0.317 |
|
1966 |
Aghajanian G, Bloom F, Lovell R, Sheard M, Freedman D. The uptake of 5-hydroxytryptamine-3H from the cerebral ventricles: autoradiographic localization Biochemical Pharmacology. 15: 1401-1403. DOI: 10.1016/0006-2952(66)90051-7 |
0.534 |
|
1966 |
Freedman DX, Aghajanian GK. Approaches to the pharmacology of LSD-25 Lloydia. 29: 309-314. |
0.485 |
|
1958 |
FREEDMAN DX, AGHAJANIAN GK, ORNITZ EM. Patterns of tolerance to lysergic acid diethylamide and mescaline in rats. Science (New York, N.Y.). 127: 1173-4. PMID 13555858 DOI: 10.1126/Science.127.3307.1173 |
0.537 |
|
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