George K. Aghajanian - Publications

Yale University, New Haven, CT 

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Liu RJ, Duman C, Kato T, Hare B, Lopresto D, Bang E, Burgdorf J, Moskal J, Taylor J, Aghajanian G, Duman RS. GLYX-13 Produces Rapid Antidepressant Responses with Key Synaptic and Behavioral Effects Distinct from Ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27634355 DOI: 10.1038/Npp.2016.202  0.336
2015 Fuchikami M, Thomas A, Liu R, Wohleb ES, Land BB, DiLeone RJ, Aghajanian GK, Duman RS. Optogenetic stimulation of infralimbic PFC reproduces ketamine's rapid and sustained antidepressant actions. Proceedings of the National Academy of Sciences of the United States of America. 112: 8106-11. PMID 26056286 DOI: 10.1073/Pnas.1414728112  0.305
2015 Liu RJ, Ota KT, Dutheil S, Duman RS, Aghajanian GK. Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2066-75. PMID 25759300 DOI: 10.1038/Npp.2015.70  0.307
2014 Ota KT, Liu RJ, Voleti B, Maldonado-Aviles JG, Duric V, Iwata M, Dutheil S, Duman C, Boikess S, Lewis DA, Stockmeier CA, DiLeone RJ, Rex C, Aghajanian GK, Duman RS. REDD1 is essential for stress-induced synaptic loss and depressive behavior. Nature Medicine. 20: 531-5. PMID 24728411 DOI: 10.1038/Nm.3513  0.306
2014 Land BB, Narayanan NS, Liu RJ, Gianessi CA, Brayton CE, Grimaldi DM, Sarhan M, Guarnieri DJ, Deisseroth K, Aghajanian GK, DiLeone RJ. Medial prefrontal D1 dopamine neurons control food intake. Nature Neuroscience. 17: 248-53. PMID 24441680 DOI: 10.1038/Nn.3625  0.307
2014 Duman RS, Aghajanian GK. Neurobiology of rapid acting antidepressants: role of BDNF and GSK-3β. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 233. PMID 24317309 DOI: 10.1038/npp.2013.217  0.309
2013 Voleti B, Navarria A, Liu RJ, Banasr M, Li N, Terwilliger R, Sanacora G, Eid T, Aghajanian G, Duman RS. Scopolamine rapidly increases mammalian target of rapamycin complex 1 signaling, synaptogenesis, and antidepressant behavioral responses. Biological Psychiatry. 74: 742-9. PMID 23751205 DOI: 10.1016/J.Biopsych.2013.04.025  0.325
2013 Liu RJ, Fuchikami M, Dwyer JM, Lepack AE, Duman RS, Aghajanian GK. GSK-3 inhibition potentiates the synaptogenic and antidepressant-like effects of subthreshold doses of ketamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2268-77. PMID 23680942 DOI: 10.1038/Npp.2013.128  0.306
2012 Duman RS, Aghajanian GK. Synaptic dysfunction in depression: potential therapeutic targets. Science (New York, N.Y.). 338: 68-72. PMID 23042884 DOI: 10.1126/science.1222939  0.321
2012 Liu RJ, Lee FS, Li XY, Bambico F, Duman RS, Aghajanian GK. Brain-derived neurotrophic factor Val66Met allele impairs basal and ketamine-stimulated synaptogenesis in prefrontal cortex. Biological Psychiatry. 71: 996-1005. PMID 22036038 DOI: 10.1016/J.Biopsych.2011.09.030  0.301
2012 Duman RS, Li N, Liu RJ, Duric V, Aghajanian G. Signaling pathways underlying the rapid antidepressant actions of ketamine. Neuropharmacology. 62: 35-41. PMID 21907221 DOI: 10.1016/J.Neuropharm.2011.08.044  0.31
2011 Li N, Liu RJ, Dwyer JM, Banasr M, Lee B, Son H, Li XY, Aghajanian G, Duman RS. Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure. Biological Psychiatry. 69: 754-61. PMID 21292242 DOI: 10.1016/J.Biopsych.2010.12.015  0.317
2010 Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M, Li XY, Aghajanian G, Duman RS. mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science (New York, N.Y.). 329: 959-64. PMID 20724638 DOI: 10.1126/Science.1190287  0.311
2010 Sears RM, Liu RJ, Narayanan NS, Sharf R, Yeckel MF, Laubach M, Aghajanian GK, DiLeone RJ. Regulation of nucleus accumbens activity by the hypothalamic neuropeptide melanin-concentrating hormone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8263-73. PMID 20554878 DOI: 10.1523/Jneurosci.5858-09.2010  0.305
2007 Lambe EK, Liu RJ, Aghajanian GK. Schizophrenia, hypocretin (orexin), and the thalamocortical activating system. Schizophrenia Bulletin. 33: 1284-90. PMID 17656637 DOI: 10.1093/schbul/sbm088  0.644
2007 Lambe EK, Aghajanian GK. Prefrontal cortical network activity: Opposite effects of psychedelic hallucinogens and D1/D5 dopamine receptor activation. Neuroscience. 145: 900-10. PMID 17293055 DOI: 10.1016/j.neuroscience.2006.12.048  0.649
2007 Heninger GR, Krystal JH, Duman RS, Bunney BS, Bowers MB, Aghajanian GK. The Neuroscience Research Program at the Connecticut Mental Health Center 40 Years of Academic Public Psychiatry. 77-95. DOI: 10.1002/9780470994580.ch4  0.497
2006 Weisstaub NV, Zhou M, Lira A, Lambe E, González-Maeso J, Hornung JP, Sibille E, Underwood M, Itohara S, Dauer WT, Ansorge MS, Morelli E, Mann JJ, Toth M, Aghajanian G, et al. Cortical 5-HT2A receptor signaling modulates anxiety-like behaviors in mice. Science (New York, N.Y.). 313: 536-40. PMID 16873667 DOI: 10.1126/Science.1123432  0.642
2006 Han MH, Bolaños CA, Green TA, Olson VG, Neve RL, Liu RJ, Aghajanian GK, Nestler EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 4624-9. PMID 16641242 DOI: 10.1523/Jneurosci.4701-05.2006  0.309
2006 Rios M, Lambe EK, Liu R, Teillon S, Liu J, Akbarian S, Roffler-Tarlov S, Jaenisch R, Aghajanian GK. Severe deficits in 5-HT2A -mediated neurotransmission in BDNF conditional mutant mice. Journal of Neurobiology. 66: 408-20. PMID 16408297 DOI: 10.1002/Neu.20233  0.655
2006 Lambe EK, Aghajanian GK. Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 1682-9. PMID 16292328 DOI: 10.1038/sj.npp.1300944  0.65
2005 Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK. Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5225-9. PMID 15917462 DOI: 10.1523/JNEUROSCI.0719-05.2005  0.638
2005 Liu RJ, Lambe EK, Aghajanian GK. Somatodendritic autoreceptor regulation of serotonergic neurons: dependence on L-tryptophan and tryptophan hydroxylase-activating kinases. The European Journal of Neuroscience. 21: 945-58. PMID 15787701 DOI: 10.1111/j.1460-9568.2005.03930.x  0.648
2005 Lambe EK, Aghajanian GK. Effects of hypocretin/orexin on the thalamocortical activating system Hypocretins: Integrators of Physiological Functions. 191-202. DOI: 10.1007/0-387-25446-3_12  0.597
2003 Lambe EK, Aghajanian GK. Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice. Neuron. 40: 139-50. PMID 14527439 DOI: 10.1016/S0896-6273(03)00598-1  0.644
2003 Lambe EK, Picciotto MR, Aghajanian GK. Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 216-25. PMID 12589374 DOI: 10.1038/sj.npp.1300032  0.648
2003 Aghajanian G, Bunney BS, Holzman PS. Patricia Goldman-Rakic, 1937–2003 Neuropsychopharmacology. 28: 2218-2220. DOI: 10.1038/sj.npp.1300325  0.566
2002 Akbarian S, Rios M, Liu RJ, Gold SJ, Fong HF, Zeiler S, Coppola V, Tessarollo L, Jones KR, Nestler EJ, Aghajanian GK, Jaenisch R. Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 4153-62. PMID 12019333 DOI: 10.1523/Jneurosci.22-10-04153.2002  0.303
2002 van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB. Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. The Journal of Physiology. 541: 169-85. PMID 12015428 DOI: 10.1113/jphysiol.2002.017426  0.31
2001 Lambe EK, Aghajanian GK. The role of Kv1.2-containing potassium channels in serotonin-induced glutamate release from thalamocortical terminals in rat frontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9955-63. PMID 11739602 DOI: 10.1523/Jneurosci.21-24-09955.2001  0.659
2001 Akbarian S, Bates B, Liu RJ, Skirboll SL, Pejchal T, Coppola V, Sun LD, Fan G, Kucera J, Wilson MA, Tessarollo L, Kosofsky BE, Taylor JR, Bothwell M, Nestler EJ, ... Aghajanian GK, et al. Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular Psychiatry. 6: 593-604. PMID 11526474 DOI: 10.1038/Sj.Mp.4000897  0.306
2000 Lambe EK, Goldman-Rakic PS, Aghajanian GK. Serotonin induces EPSCs preferentially in layer V pyramidal neurons of the frontal cortex in the rat. Cerebral Cortex (New York, N.Y. : 1991). 10: 974-80. PMID 11007548 DOI: 10.1093/cercor/10.10.974  0.716
1999 Schoepp DD, Monn JA, Marek GJ, Aghajanian G, Moghaddam B. LY354740: A systemically active mGlu2/mGlu3 receptor agonist Cns Drug Reviews. 5: 1-12. DOI: 10.1111/J.1527-3458.1999.Tb00082.X  0.483
1999 Krystal JH, Belger A, D'Souza DC, Anand A, Charney DS, Aghajanian GK, Moghaddam B. Therapeutic implications of the hyperglutamatergic effects of NMDA antagonists Neuropsychopharmacology. 21: S143-S157. DOI: 10.1016/S0893-133X(99)00102-5  0.558
1996 Rasmussen K, Kendrick WT, Kogan JH, Aghajanian GK. A selective AMPA antagonist, LY293558, suppresses morphine withdrawal-induced activation of locus coeruleus neurons and behavioral signs of morphine withdrawal. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 497-505. PMID 8914123 DOI: 10.1016/S0893-133X(96)00094-2  0.504
1996 Pineda J, Kogan JH, Aghajanian GK. Nitric oxide and carbon monoxide activate locus coeruleus neurons through a cGMP-dependent protein kinase: involvement of a nonselective cationic channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 1389-99. PMID 8778290 DOI: 10.1523/Jneurosci.16-04-01389.1996  0.308
1995 Kogan JH, Aghajanian GK. Long-term glutamate desensitization in locus coeruleus neurons and its role in opiate withdrawal. Brain Research. 689: 111-21. PMID 8528694 DOI: 10.1016/0006-8993(95)00545-2  0.314
1994 Iyer RN, Sprouse JS, Aghajanian GK, Roth RH, Bradberry CW. Tryptophan pretreatment augmentation of p-chloroamphetamine-induced serotonin and dopamine release and reduction of long-term neurotoxicity. Biochemical Pharmacology. 48: 1501-8. PMID 7945451 DOI: 10.1016/0006-2952(94)90576-2  0.459
1994 Aghajanian GK, Kogan JH, Moghaddam B. Opiate withdrawal increases glutamate and aspartate efflux in the locus coeruleus: an in vivo microdialysis study. Brain Research. 636: 126-30. PMID 7908850 DOI: 10.1016/0006-8993(94)90186-4  0.551
1992 Kogan JH, Nestler EJ, Aghajanian GK. Elevated basal firing rates and enhanced responses to 8-Br-cAMP in locus coeruleus neurons in brain slices from opiate-dependent rats. European Journal of Pharmacology. 211: 47-53. PMID 1618268 DOI: 10.1016/0014-2999(92)90261-2  0.32
1991 Rasmussen K, Krystal JH, Aghajanian GK. Excitatory amino acids and morphine withdrawal: differential effects of central and peripheral kynurenic acid administration. Psychopharmacology. 105: 508-12. PMID 1771218 DOI: 10.1007/Bf02244371  0.464
1991 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. Sub-picogram determination of serotonin using HPLC with electrochemical detection for microdialysis studies of serotonin release. Advances in Experimental Medicine and Biology. 294: 81-9. PMID 1685295 DOI: 10.1007/978-1-4684-5952-4_7  0.459
1991 Bradberry CW, Sprouse JS, Sheldon PW, Aghajanian GK, Roth RH. In vitro microdialysis: a novel technique for stimulated neurotransmitter release measurements. Journal of Neuroscience Methods. 36: 85-90. PMID 1676433 DOI: 10.1016/0165-0270(91)90141-L  0.459
1991 Deutch AY, Moghaddam B, Innis RB, Krystal JH, Aghajanian GK, Bunney BS, Charney DS. Mechanisms of action of atypical antipsychotic drugs. Implications for novel therapeutic strategies for schizophrenia. Schizophrenia Research. 4: 121-56. PMID 1674882 DOI: 10.1016/0920-9964(91)90030-U  0.682
1990 Bradberry CW, Sprouse JS, Aghajanian GK, Roth RH. 3,4-methylenedioxymethamphetamine (MDMA)-induced release of endogenous serotonin from the rat dorsal raphe nucleus in vitro: Effects of fluoxetine and tryptophan. Neurochemistry International. 17: 509-13. PMID 20504652 DOI: 10.1016/0197-0186(90)90037-T  0.459
1990 Rasmussen K, Aghajanian GK. Serotonin excitation of facial motoneurons: receptor subtype characterization. Synapse (New York, N.Y.). 5: 324-32. PMID 2360199 DOI: 10.1002/Syn.890050409  0.464
1990 Aghajanian GK, Sprouse JS, Sheldon P, Rasmussen K. Electrophysiology of the central serotonin system: receptor subtypes and transducer mechanisms. Annals of the New York Academy of Sciences. 600: 93-103; discussion 1. PMID 2123618 DOI: 10.1111/J.1749-6632.1990.Tb16875.X  0.464
1990 Rasmussen K, Beitner-Johnson DB, Krystal JH, Aghajanian GK, Nestler EJ. Opiate withdrawal and the rat locus coeruleus: behavioral, electrophysiological, and biochemical correlates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2308-17. PMID 2115910 DOI: 10.1523/Jneurosci.10-07-02308.1990  0.464
1990 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. 3,4-Methylenedioxymethamphetamine-induced release of serotonin and inhibition of dorsal raphe cell firing: potentiation by L-tryptophan. European Journal of Pharmacology. 178: 313-20. PMID 1971220 DOI: 10.1016/0014-2999(90)90110-R  0.459
1989 Rasmussen K, Aghajanian GK. Failure to block responses of locus coeruleus neurons to somatosensory stimuli by destruction of two major afferent nuclei. Synapse (New York, N.Y.). 4: 162-4. PMID 2781467 DOI: 10.1002/Syn.890040210  0.464
1989 Aghajanian GK, Rasmussen K. Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices. Synapse (New York, N.Y.). 3: 331-8. PMID 2740992 DOI: 10.1002/Syn.890030406  0.464
1989 Rasmussen K, Aghajanian GK. Withdrawal-induced activation of locus coeruleus neurons in opiate-dependent rats: attenuation by lesions of the nucleus paragigantocellularis. Brain Research. 505: 346-50. PMID 2598056 DOI: 10.1016/0006-8993(89)91466-2  0.464
1989 Sprouse JS, Bradberry CW, Roth RH, Aghajanian GK. MDMA (3,4-methylenedioxymethamphetamine) inhibits the firing of dorsal raphe neurons in brain slices via release of serotonin. European Journal of Pharmacology. 167: 375-83. PMID 2572435 DOI: 10.1016/0014-2999(89)90446-9  0.459
1988 Innis RB, Nestler EJ, Aghajanian GK. Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Research. 459: 27-36. PMID 3139262 DOI: 10.1016/0006-8993(88)90282-X  0.333
1988 Rasmussen K, Aghajanian GK. Potency of antipsychotics in reversing the effects of a hallucinogenic drug on locus coeruleus neurons correlates with 5-HT2 binding affinity. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 1: 101-7. PMID 2908015 DOI: 10.1016/0893-133X(88)90001-2  0.391
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks autoreceptor-mediated inhibition of dopaminergic neurons in rat substantia nigra. Brain Research. 411: 139-43. PMID 2955848 DOI: 10.1016/0006-8993(87)90690-1  0.308
1987 Innis RB, Aghajanian GK. Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. European Journal of Pharmacology. 143: 195-204. PMID 2826189 DOI: 10.1016/0014-2999(87)90533-4  0.342
1986 Innis RB, Aghajanian GK. Cholecystokinin-containing and nociceptive neurons in rat Edinger-Westphal nucleus. Brain Research. 363: 230-8. PMID 3942895 DOI: 10.1016/0006-8993(86)91008-5  0.31
1986 Rasmussen K, Glennon RA, Aghajanian GK. Phenethylamine hallucinogens in the locus coeruleus: potency of action correlates with rank order of 5-HT2 binding affinity. European Journal of Pharmacology. 132: 79-82. PMID 3816969 DOI: 10.1016/0014-2999(86)90014-2  0.491
1986 Rasmussen K, Aghajanian GK. Effect of hallucinogens on spontaneous and sensory-evoked locus coeruleus unit activity in the rat: reversal by selective 5-HT2 antagonists. Brain Research. 385: 395-400. PMID 3096493 DOI: 10.1016/0006-8993(86)91090-5  0.464
1985 Lakoski JM, Aghajanian GK. Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus. Neuropharmacology. 24: 265-73. PMID 3158835 DOI: 10.1016/0028-3908(85)90130-3  0.335
1985 Andrade R, Aghajanian GK. Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'-monophosphate analogues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 5: 2359-64. PMID 2993542 DOI: 10.1523/Jneurosci.05-09-02359.1985  0.472
1985 Innis RB, Aghajanian GK. Integrated anatomical and physiological studies of neuronal cholecystokinin receptors. Annals of the New York Academy of Sciences. 448: 188-97. PMID 2992344 DOI: 10.1111/J.1749-6632.1985.Tb29918.X  0.301
1985 Innis RB, Andrade R, Aghajanian GK. Substance K excites dopaminergic and non-dopaminergic neurons in rat substantia nigra. Brain Research. 335: 381-3. PMID 2408703 DOI: 10.1016/0006-8993(85)90499-8  0.498
1984 Andrade R, Aghajanian GK. Intrinsic regulation of locus coeruleus neurons: electrophysiological evidence indicating a predominant role for autoinhibition. Brain Research. 310: 401-6. PMID 6488034 DOI: 10.1016/0006-8993(84)90170-7  0.472
1984 Aghajanian GK, Lakoski JM. Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Research. 305: 181-5. PMID 6331598 DOI: 10.1016/0006-8993(84)91137-5  0.324
1984 Andrade R, Aghajanian GK. Locus coeruleus activity in vitro: intrinsic regulation by a calcium-dependent potassium conductance but not alpha 2-adrenoceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 4: 161-70. PMID 6319626 DOI: 10.1523/Jneurosci.04-01-00161.1984  0.472
1984 Lakoski JM, Gallager DW, Aghajanian GK. Histamine-induced depression of serotoninergic dorsal raphe neurons: antagonism by cimetidine, a reevaluation. European Journal of Pharmacology. 103: 153-6. PMID 6148254 DOI: 10.1016/0014-2999(84)90202-4  0.317
1983 Andrade R, Vandermaelen CP, Aghajanian GK. Morphine tolerance and dependence in the locus coeruleus: single cell studies in brain slices. European Journal of Pharmacology. 91: 161-9. PMID 6684572 DOI: 10.1016/0014-2999(83)90461-2  0.472
1983 Aghajanian GK, Vandermaelen CP, Andrade R. Intracellular studies on the role of calcium in regulating the activity and reactivity of locus coeruleus neurons in vivo. Brain Research. 273: 237-43. PMID 6311349 DOI: 10.1016/0006-8993(83)90848-X  0.472
1983 Aghajanian GK, Rogawski MA. The physiological role of α-adrenoceptors in the CNS: new concepts from single-cell studies Trends in Pharmacological Sciences. 4: 315-317. DOI: 10.1016/0165-6147(83)90417-0  0.506
1982 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by locus coeruleus or dorsal noradrenergic bundle stimulation: selective blockade by the alpha 1-adrenoceptor antagonist prazosin. Brain Research. 250: 31-9. PMID 7139319 DOI: 10.1016/0006-8993(82)90950-7  0.548
1982 Andrade R, Aghajanian GK. Single cell activity in the noradrenergic A-5 region: responses to drugs and peripheral manipulations of blood pressure. Brain Research. 242: 125-35. PMID 6125245 DOI: 10.1016/0006-8993(82)90502-9  0.472
1981 Rogawski MA, Aghajanian GK. Serotonin autoreceptors on dorsal raphe neurons: structure-activity relationships of tryptamine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1148-54. PMID 6793698 DOI: 10.1523/Jneurosci.01-10-01148.1981  0.537
1981 Baraban JM, Aghajanian GK. Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Research. 204: 1-11. PMID 6166350 DOI: 10.1016/0006-8993(81)90646-6  0.553
1981 Menkes DB, Baraban JM, Aghajanian GK. Prazosin selectively antagonizes neuronal responses mediated by alpha1-adrenoceptors in brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 317: 273-5. PMID 6119624 DOI: 10.1007/BF00503830  0.553
1980 Rogawski MA, Aghajanian GK. Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Experimental Neurology. 69: 678-94. PMID 7409069 DOI: 10.1016/0014-4886(80)90060-6  0.551
1980 McCall RB, Aghajanian GK. Pharmacological characterization of serotonin receptors in the facial motor nucleus: a microiontophoretic study. European Journal of Pharmacology. 65: 175-83. PMID 7398786 DOI: 10.1016/0014-2999(80)90390-8  0.311
1980 McCall RB, Aghajanian GK. Hallucinogens potentiate responses to serotonin and norepinephrine in the facial motor nucleus. Life Sciences. 26: 1149-56. PMID 7392793 DOI: 10.1016/0024-3205(80)90654-2  0.32
1980 De Montigny C, Wang RY, Reader TA, Aghajanian GK. Monoaminergic denervation of the rat hippocampus: microiontophoretic studies on pre- and postsynaptic supersensitivity to norepinephrine and serotonin. Brain Research. 200: 363-76. PMID 6968237 DOI: 10.1016/0006-8993(80)90927-0  0.333
1980 Rogawski MA, Aghajanian GK. Modulation of lateral geniculate neurone excitability by noradrenaline microiontophoresis or locus coeruleus stimulation. Nature. 287: 731-4. PMID 6253811 DOI: 10.1038/287731a0  0.546
1980 Menkes DB, Aghajanian GK, McCall RB. Chronic antidepressant treatment enhances alpha-adrenergic and serotonergic responses in the facial nucleus. Life Sciences. 27: 45-55. PMID 6249992 DOI: 10.1016/0024-3205(80)90018-1  0.317
1980 Baraban JM, Aghajanian GK. Suppression of serotonergic neuronal firing by alpha-adrenoceptor antagonists: evidence against GABA mediation. European Journal of Pharmacology. 66: 287-94. PMID 6106551 DOI: 10.1016/0014-2999(80)90461-6  0.553
1980 Baraban JM, Aghajanian GK. Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists. Neuropharmacology. 19: 355-63. PMID 6104308 DOI: 10.1016/0028-3908(80)90187-2  0.553
1980 Rogawski MA, Aghajanian GK. Activation of lateral geniculate neurons by norepinephrine: mediation by an alpha-adrenergic receptor. Brain Research. 182: 345-59. PMID 6101983 DOI: 10.1016/0006-8993(80)91193-2  0.537
1979 Wang RY, de Montigny C, Gold BI, Roth RH, Aghajanian GK. Denervation supersensitivity to serotonin in rat forebrain: single cell studies. Brain Research. 178: 479-97. PMID 509215 DOI: 10.1016/0006-8993(79)90708-X  0.459
1979 Guyenet PG, Mroz EA, Aghajanian GK, Leeman SE. Delayed iontophoretic ejection of substance P from glass micropipettes: correlation with time-course of neuronal excitation in vivo. Neuropharmacology. 18: 553-8. PMID 481708 DOI: 10.1016/0028-3908(79)90100-X  0.513
1979 Rogawski MA, Aghajanian GK. Response of central monoaminergic neurons to lisuride: comparison with LSD. Life Sciences. 24: 1289-97. PMID 470543 DOI: 10.1016/0024-3205(79)90148-6  0.544
1979 McCall RB, Aghajanian GK. Denervation supersensitivity to serotonin in the facial nucleus. Neuroscience. 4: 1501-10. PMID 317926 DOI: 10.1016/0306-4522(79)90055-1  0.313
1979 Rogawski MA, Roth RH, Aghajanian GK. Melatonin: deacetylation to 5-methoxytryptamine by liver but not brain aryl acylamidase. Journal of Neurochemistry. 32: 1219-26. PMID 285213 DOI: 10.1111/j.1471-4159.1979.tb11049.x  0.597
1979 Guyenet PG, Aghajanian GK. ACh, substance P and met-enkephalin in the locus coeruleus: pharmacological evidence for independent sites of action. European Journal of Pharmacology. 53: 319-28. PMID 217695 DOI: 10.1016/0014-2999(79)90455-2  0.513
1978 Bunney BS, Aghajanian GK. d-Amphetamine-induced depression of central dopamine neurons: evidence for mediation by both autoreceptors and a striato-nigral feedback pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. 304: 255-61. PMID 714182 DOI: 10.1007/BF00507966  0.566
1978 Aghajanian GK, Wang RY, Baraban J. Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation. Brain Research. 153: 169-75. PMID 679043 DOI: 10.1016/0006-8993(78)91140-X  0.553
1978 Cedarbaum JM, Aghajanian GK. Afferent projections to the rat locus coeruleus as determined by a retrograde tracing technique. The Journal of Comparative Neurology. 178: 1-16. PMID 632368 DOI: 10.1002/Cne.901780102  0.563
1978 Cedarbaum JM, Aghajanian GK. Activation of locus coeruleus neurons by peripheral stimuli: modulation by a collateral inhibitory mechanism. Life Sciences. 23: 1383-92. PMID 214648 DOI: 10.1016/0024-3205(78)90398-3  0.563
1978 Baraban JM, Wang RY, Aghajanian G. Reserpine suppression of dorsal raphe neuronal firing: mediation by adrenergic system. European Journal of Pharmacology. 52: 27-36. PMID 214312 DOI: 10.1016/0014-2999(78)90018-3  0.553
1978 Guyenet PG, Aghajanian GK. Antidromic identification of dopaminergic and other output neurons of the rat substantia nigra. Brain Research. 150: 69-84. PMID 78748 DOI: 10.1016/0006-8993(78)90654-6  0.513
1977 Aghajanian GK, Cedarbaum JM, Wang RY. Evidence for norepinephrine-mediated collateral inhibition of locus coeruleus neurons. Brain Research. 136: 570-7. PMID 922502 DOI: 10.1016/0006-8993(77)90083-X  0.563
1977 Bunney BS, Aghajanian GK. D-Amphetamine-induced inhibition of central dopaminergic neurons: direct effect or mediated by a striatonigral feedback pathway? Advances in Biochemical Psychopharmacology. 16: 577-82. PMID 883560  0.521
1977 Aghajanian GK, Bunney BS. Pharmacological characterization of dopamine "autoreceptors" by microiontophoretic single-cell recording studies. Advances in Biochemical Psychopharmacology. 16: 433-8. PMID 883551  0.521
1977 Davis M, Gallager DW, Aghajanian GK. Tricyclic antidepressant drugs: Attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response Life Sciences. 20: 1249-1257. PMID 850475 DOI: 10.1016/0024-3205(77)90499-4  0.313
1977 Guyenet PG, Aghajanian GK. Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides. Brain Research. 136: 178-84. PMID 412562 DOI: 10.1016/0006-8993(77)90144-5  0.513
1977 Davis M, Cedarbaum JM, Aghajanian GK, Gendelman DS. Effects of clonidine on habituation and sensitization of acoustic startle in normal, decerebrate and locus coeruleus lesioned rats. Psychopharmacology. 51: 243-53. PMID 403539 DOI: 10.1007/Bf00431631  0.578
1977 Cedarbaum JM, Aghajanian GK. Catecholamine receptors on locus coeruleus neurons: pharmacological characterization. European Journal of Pharmacology. 44: 375-85. PMID 330174 DOI: 10.1016/0014-2999(77)90312-0  0.563
1977 Bunney BS, Aghajanian GK. Electrophysiological studies of dopamine- innervated cells in the frontal cortex. Advances in Biochemical Psychopharmacology. 16: 65-70. PMID 329653  0.521
1977 Aghajanian GK, Bunney BS. Dopamine"autoreceptors": pharmacological characterization by microiontophoretic single cell recording studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 297: 1-7. PMID 193046 DOI: 10.1007/BF00508803  0.566
1976 Bunney BS, Aghajanian GK. Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: pharmacological differentiation using microiontophoretic techniques. Life Sciences. 19: 1783-9. PMID 1004134 DOI: 10.1016/0024-3205(76)90087-4  0.566
1976 Bunney BS, Aghajanian GK. The precise localization of nigral afferents in the rat as determined by a retrograde tracing technique. Brain Research. 117: 423-35. PMID 990939 DOI: 10.1016/0006-8993(76)90751-4  0.566
1976 Bunney BS, Aghajanian GK. Dopaminergic infllence in the basal ganglia: evidence for striatonigral feedback regulation. Research Publications - Association For Research in Nervous and Mental Disease. 55: 249-67. PMID 826996  0.521
1976 Cedarbaum JM, Aghajanian GK. Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the alpha-antagonist piperoxane. Brain Research. 112: 413-9. PMID 8191 DOI: 10.1016/0006-8993(76)90297-3  0.563
1975 Bunney BS, Roth RH, Aghajanian GK. Effects of molindone on central dopaminergic neuronal activity and metabolism: similarity to other neuroleptics. Psychopharmacology Communications. 1: 349-58. PMID 1224004  0.521
1975 Bunney BS, Walters JR, Kuhar MJ, Roth RH, Aghajanian GK. D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons. Psychopharmacology Communications. 1: 177-90. PMID 1223998  0.689
1975 Svensson TH, Bunney BS, Aghajanian GK. Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine. Brain Research. 92: 291-306. PMID 1174954 DOI: 10.1016/0006-8993(75)90276-0  0.566
1975 Nybäck HV, Walters JR, Aghajanian GK, Roth RH. Tricyclic antidepressants: effects on the firing rate of brain noradrenergic neurons. European Journal of Pharmacology. 32: 302-12. PMID 1149813 DOI: 10.1016/0014-2999(75)90297-6  0.584
1975 Bunney BS, Aghajanian GK. Evidence for drug actions on both pre- and postsynaptic catecholamine receptors in the CNS. Psychopharmacology Bulletin. 11: 8-10. PMID 724  0.521
1975 Aghajanian GK, Bunney BS. Dopaminergic and non dopaminergic neurons of the substantia nigra: differential responses to putative transmitters | NEUROPSYCHOPHARMACOLOGY. PROCEEDINGS OF THE CONGRESS OF THE COLLEGIUM INTERNATIONALE NEUROPSYCHOPHARMACOLOGICUM, PARIS, 7-12 JULY, 1974 Excerpta Medica. 444-452.  0.521
1974 Kuhar MJ, Aghajanian GK, Roth RH. Serotonin neurons: a synaptic mechanism for the reuptake of serotonin. Advances in Biochemical Psychopharmacology. 10: 287-95. PMID 4846544  0.43
1974 Bunney BS, Aghajanian GK. A comparison of the effects of chlorpromazine, 7-hydroxychlorpromazine and chlorpromazine sulfoxide on the activity of central dopaminergic neurons. Life Sciences. 15: 309-18. PMID 4549921 DOI: 10.1016/0024-3205(74)90221-5  0.566
1974 Bunney BS, Aghajanian GK. Proceedings: Differentiation between neuroleptic antipsychotic properties and side effects by subgroups of dopaminergic neurons. Psychopharmacology Bulletin. 10: 17-8. PMID 4473793  0.521
1974 Korf J, Bunney BS, Aghajanian GK. Noradrenergic neurons: morphine inhibition of spontaneous activity. European Journal of Pharmacology. 25: 165-9. PMID 4435020 DOI: 10.1016/0014-2999(74)90045-4  0.566
1974 Bunney BS, Aghajanian GK. Antipsychotic drugs and amphetamine: Direct evidence for an action of dopaminergic neurons Journal of Psychiatric Research. 10: 150. DOI: 10.1016/0022-3956(74)90036-3  0.521
1974 Bunney BS, Aghajanian GK. Electrophysiological effects of amphetamine on dopaminergic neurons Biochemical Pharmacology. 23: 792-797. DOI: 10.1016/0006-2952(74)90134-8  0.566
1974 Aghajanian GK, Bunney BS. Central dopaminergic neurons: Neurophysiological identification and responses to drugs Biochemical Pharmacology. 23: 523-528. DOI: 10.1016/0006-2952(74)90074-4  0.566
1973 Korf J, Aghajanian GK, Roth RH. Increased turnover of norepinephrine in the rat cerebral cortex during stress: role of the locus coeruleus. Neuropharmacology. 12: 933-8. PMID 4750561 DOI: 10.1016/0028-3908(73)90024-5  0.459
1973 Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: similar biochemical and histochemical effects of gamma-hydroxybutyrate and acute lesions of the nigro-neostriatal pathway. The Journal of Pharmacology and Experimental Therapeutics. 186: 630-9. PMID 4728341  0.543
1973 Korf J, Aghajanian GK, Roth RH. Stimulation and destruction of the locus coeruleus: opposite effects on 3-methoxy-4-hydroxyphenylglycol sulfate levels in the rat cerebral cortex. European Journal of Pharmacology. 21: 305-10. PMID 4708068 DOI: 10.1016/0014-2999(73)90131-3  0.459
1973 Touloukian RJ, Aghajanian G, Roth RH. Adrenergic hyperactivity of the aganglionic colon Journal of Pediatric Surgery. 8: 191-195. PMID 4698355 DOI: 10.1016/S0022-3468(73)80084-3  0.459
1973 Kuhar MJ, Sethy VH, Roth RH, Aghajanian GK. Choline: selective accumulation by central cholinergic neurons. Journal of Neurochemistry. 20: 581-93. PMID 4698301 DOI: 10.1111/J.1471-4159.1973.Tb12157.X  0.492
1973 Korf J, Roth RH, Aghajanian GK. Alterations in turnover and endogenous levels of norepinephrine in cerebral cortex following electrical stimulation and acute axotomy of cerebral noradrenergic pathways. European Journal of Pharmacology. 23: 276-82. PMID 4583563 DOI: 10.1016/0014-2999(73)90095-2  0.459
1973 Bunney BS, Walters JR, Roth RH, Aghajanian GK. Dopaminergic neurons: effect of antipsychotic drugs and amphetamine on single cell activity. The Journal of Pharmacology and Experimental Therapeutics. 185: 560-71. PMID 4576427  0.675
1973 Bunney BS, Aghajanian GK, Roth RH. Comparison of effects of L-dopa, amphetamine and apomorphine on firing rate of rat dopaminergic neurones. Nature: New Biology. 245: 123-5. PMID 4518113 DOI: 10.1038/Newbio245123A0  0.638
1973 Kuhar MJ, Aghajanian GK. Selective accumulation of 3 H-serotonin by nerve terminals of raphe neurones: an autoradiographic study. Nature: New Biology. 241: 187-9. PMID 4512580 DOI: 10.1038/Newbio241187A0  0.311
1973 Sethy VH, Kuhar MJ, Roth RH, Van Woert MH, Aghajanian GK. Cholinergic neurons: effect of acute septal lesion on acetylcholine and choline content of rat hippocampus. Brain Research. 55: 481-4. PMID 4351629 DOI: 10.1016/0006-8993(73)90318-1  0.485
1973 Aghajanian GK, Kuhar MJ, Roth RH. Serotonin-containing neuronal perikarya and terminals: differential effects of P-chlorophenylalanine. Brain Research. 54: 85-101. PMID 4267802 DOI: 10.1016/0006-8993(73)90036-X  0.5
1973 Roth RH, Walters JR, Aghajanian GK. Effect of impulse flow on the release and synthesis of dopamine in the striatum Life Sciences. 13: cxxxix-cxl. DOI: 10.1016/0024-3205(73)90387-1  0.584
1972 Touloukian RJ, Aghajanian GK, Roth RH. Adrenergic denervation of the hypertrophied gut remnant. Annals of Surgery. 176: 633-7. PMID 5079824 DOI: 10.1097/00000658-197211000-00009  0.459
1972 Kuhar MJ, Aghajanian GK, Roth RH. Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: correlations with serotonin levels and histochemical fluorescence. Brain Research. 44: 165-76. PMID 5056975 DOI: 10.1016/0006-8993(72)90372-1  0.493
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synthesis of catecholamines in the locus coeruleus from 3 H-tyrosine in vivo. Biochemical Pharmacology. 21: 2280-2. PMID 4646193 DOI: 10.1016/0006-2952(72)90047-0  0.452
1972 Aghajanian GK, Haigler HJ, Bloom FE. Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. Life Sciences. Pt. 1: Physiology and Pharmacology. 11: 615-22. PMID 4570795 DOI: 10.1016/0024-3205(72)90153-1  0.331
1972 Kuhar MJ, Roth RH, Aghajanian GK. Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. The Journal of Pharmacology and Experimental Therapeutics. 181: 36-45. PMID 4552069  0.408
1971 Kuhar MJ, Roth RH, Aghajanian GK. Selective reduction of tryptophan hydroxylase activity in rat forebrain after midbrain raphe lesions. Brain Research. 35: 167-76. PMID 4257335 DOI: 10.1016/0006-8993(71)90602-0  0.481
1971 Weiss BL, Aghajanian GK. Activation of brain serotonin metabolism by heat: Role of midbrain raphe neurons Brain Research. 26: 37-48. DOI: 10.1016/0006-8993(71)90540-3  0.327
1969 Aghajanian GK, Bloom FE, Sheard MH. Electron microscopy of degeneration within the serotonin pathway of rat brain. Brain Research. 13: 266-73. PMID 5772424 DOI: 10.1016/0006-8993(69)90286-8  0.301
1968 Aghajanian GK, Weiss BL. Block by LSD of the increase in brain serotonin turnover induced by elevated ambient temperature. Nature. 220: 795-6. PMID 5698754 DOI: 10.1038/220795a0  0.317
1966 Aghajanian G, Bloom F, Lovell R, Sheard M, Freedman D. The uptake of 5-hydroxytryptamine-3H from the cerebral ventricles: autoradiographic localization Biochemical Pharmacology. 15: 1401-1403. DOI: 10.1016/0006-2952(66)90051-7  0.534
1966 Freedman DX, Aghajanian GK. Approaches to the pharmacology of LSD-25 Lloydia. 29: 309-314.  0.485
1958 FREEDMAN DX, AGHAJANIAN GK, ORNITZ EM. Patterns of tolerance to lysergic acid diethylamide and mescaline in rats. Science (New York, N.Y.). 127: 1173-4. PMID 13555858 DOI: 10.1126/Science.127.3307.1173  0.537
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