| Year |
Citation |
Score |
| 2020 |
Zhao S, Ni F, Qiu T, Wolff JT, Tsai SC, Luo R. Molecular Basis for Polyketide Ketoreductase-Substrate Interactions. International Journal of Molecular Sciences. 21. PMID 33066287 DOI: 10.3390/ijms21207562 |
0.399 |
|
| 2019 |
Milligan JC, Lee DJ, Jackson DR, Schaub AJ, Beld J, Barajas JF, Hale JJ, Luo R, Burkart MD, Tsai SC. Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nature Chemical Biology. PMID 31209348 DOI: 10.1038/S41589-019-0301-Y |
0.753 |
|
| 2019 |
Schaub AJ, Moreno GO, Zhao S, Truong HV, Luo R, Tsai SC. Computational structural enzymology methodologies for the study and engineering of fatty acid synthases, polyketide synthases and nonribosomal peptide synthetases. Methods in Enzymology. 622: 375-409. PMID 31155062 DOI: 10.1016/Bs.Mie.2019.03.001 |
0.427 |
|
| 2018 |
Tsai SS. The Structural Enzymology of Iterative Aromatic Polyketide Synthases: A Critical Comparison with Fatty Acid Synthases. Annual Review of Biochemistry. 87: 503-531. PMID 29925265 DOI: 10.1146/annurev-biochem-063011-164509 |
0.358 |
|
| 2018 |
Ellis BD, Milligan JC, White AR, Duong V, Altman PX, Mohammed L, Crump MP, Crosby J, Luo R, Vanderwal CD, Tsai SC. An Oxetane-based Polyketide Surrogate to Probe Substrate Binding in a Polyketide Synthase. Journal of the American Chemical Society. PMID 29620883 DOI: 10.1021/Jacs.7B11793 |
0.411 |
|
| 2017 |
Jackson DR, Shakya G, Patel AB, Mohammed LY, Vasilakis K, Wattana-Amorn P, Valentic TR, Milligan J, Crump MP, Crosby J, Tsai SC. Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. Acs Chemical Biology. PMID 29161022 DOI: 10.1021/acschembio.7b00551 |
0.414 |
|
| 2017 |
White A, Kozlowski R, Tsai SC, Vanderwal CD. A Direct Synthesis of Highly Substituted π-Rich Aromatic Heterocycles from Oxetanes. Angewandte Chemie (International Ed. in English). PMID 28662280 DOI: 10.1002/Anie.201704119 |
0.319 |
|
| 2017 |
Barajas JF, Shakya G, Moreno G, Rivera H, Jackson DR, Topper CL, Vagstad AL, La Clair JJ, Townsend CA, Burkart MD, Tsai SC. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484029 DOI: 10.1073/Pnas.1609001114 |
0.778 |
|
| 2016 |
Ray L, Valentic TR, Miyazawa T, Withall DM, Song L, Milligan JC, Osada H, Takahashi S, Tsai SC, Challis GL. A crotonyl-CoA reductase-carboxylase independent pathway for assembly of unusual alkylmalonyl-CoA polyketide synthase extender units. Nature Communications. 7: 13609. PMID 28000660 DOI: 10.1038/ncomms13609 |
0.322 |
|
| 2016 |
Valentic TR, Jackson DR, Brady SF, Tsai SS. Comprehensive Analysis of a Novel Ketoreductase for Pentangular Polyphenol Biosynthesis. Acs Chemical Biology. PMID 27779377 DOI: 10.1021/Acschembio.6B00658 |
0.52 |
|
| 2016 |
Barajas JF, Finzel K, Valentic TR, Shakya G, Gamarra N, Martinez D, Meier JL, Vagstad AL, Newman AG, Townsend CA, Burkart MD, Tsai SC. Structural and Biochemical Analysis of Protein-Protein Interactions Between the Acyl-Carrier Protein and Product Template Domain. Angewandte Chemie (International Ed. in English). PMID 27653519 DOI: 10.1002/Anie.201605401 |
0.762 |
|
| 2016 |
Rivera H, Dhar S, La Clair JJ, Tsai SC, Burkart MD. An unusual intramolecular trans-amidation. Tetrahedron. 72: 3605-3608. PMID 27346894 DOI: 10.1016/J.Tet.2016.01.062 |
0.35 |
|
| 2016 |
Jackson D, Yu X, Wang G, Patel A, Barajas J, Sasaki E, Metsa-Ketala M, Liu HW, Rohr J, Tsai SS. Insights Into Complex Oxidation During BE-7585A Biosynthesis: Structural Determination and Analysis of the Polyketide Monooxygenase BexE. Acs Chemical Biology. PMID 26813028 DOI: 10.1021/Acschembio.5B00913 |
0.779 |
|
| 2015 |
Caldara-Festin G, Jackson DR, Barajas JF, Valentic TR, Patel AB, Aguilar S, Nguyen M, Vo M, Khanna A, Sasaki E, Liu HW, Tsai SC. Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26631750 DOI: 10.1073/Pnas.1512976112 |
0.768 |
|
| 2015 |
Finzel K, Nguyen C, Jackson DR, Gupta A, Tsai SC, Burkart MD. Probing the Substrate Specificity and Protein-Protein Interactions of the E. coli Fatty Acid Dehydratase, FabA. Chemistry & Biology. PMID 26526101 DOI: 10.1016/J.Chembiol.2015.09.009 |
0.678 |
|
| 2015 |
Jackson DR, Tu SS, Nguyen M, Barajas JF, Schaub AJ, Krug D, Pistorius D, Luo R, Müller R, Tsai SC. Structural Insights into Anthranilate Priming during Type II Polyketide Biosynthesis. Acs Chemical Biology. PMID 26473393 DOI: 10.1021/Acschembio.5B00500 |
0.786 |
|
| 2015 |
Barajas JF, Phelan RM, Schaub AJ, Kliewer JT, Kelly PJ, Jackson DR, Luo R, Keasling JD, Tsai SC. Comprehensive Structural and Biochemical Analysis of the Terminal Myxalamid Reductase Domain for the Engineered Production of Primary Alcohols. Chemistry & Biology. PMID 26235055 DOI: 10.1016/J.Chembiol.2015.06.022 |
0.778 |
|
| 2014 |
Shakya G, Rivera H, Lee DJ, Jaremko MJ, La Clair JJ, Fox DT, Haushalter RW, Schaub AJ, Bruegger J, Barajas JF, White AR, Kaur P, Gwozdziowski ER, Wong F, Tsai SC, et al. Modeling linear and cyclic PKS intermediates through atom replacement. Journal of the American Chemical Society. 136: 16792-9. PMID 25406716 DOI: 10.1021/Ja5064857 |
0.781 |
|
| 2014 |
Nguyen C, Haushalter RW, Lee DJ, Markwick PR, Bruegger J, Caldara-Festin G, Finzel K, Jackson DR, Ishikawa F, O'Dowd B, McCammon JA, Opella SJ, Tsai SC, Burkart MD. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature. 505: 427-31. PMID 24362570 DOI: 10.1038/Nature12810 |
0.805 |
|
| 2014 |
Yu X, Metsä-Ketelä M, Tsai S, Liu H, Rohr J. Roles of the key enzymes involved in the angucycline core formation in the BE-7585A biosynthesis Planta Medica. 80. DOI: 10.1055/S-0034-1382628 |
0.316 |
|
| 2013 |
Javidpour P, Bruegger J, Srithahan S, Korman TP, Crump MP, Crosby J, Burkart MD, Tsai SC. The determinants of activity and specificity in actinorhodin type II polyketide ketoreductase. Chemistry & Biology. 20: 1225-34. PMID 24035284 DOI: 10.1016/J.Chembiol.2013.07.016 |
0.783 |
|
| 2013 |
Bruegger J, Haushalter RW, Haushalter B, Vagstad AL, Vagstad A, Shakya G, Mih N, Townsend CA, Burkart MD, Tsai SC. Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chemistry & Biology. 20: 1135-46. PMID 23993461 DOI: 10.1016/J.Chembiol.2013.07.012 |
0.778 |
|
| 2012 |
Tsai SC. Babysitting flavin for biosynthesis. Chemistry & Biology. 19: 787-8. PMID 22840764 DOI: 10.1016/J.Chembiol.2012.07.006 |
0.381 |
|
| 2012 |
Ames BD, Nguyen C, Bruegger J, Smith P, Xu W, Ma S, Wong E, Wong S, Xie X, Li JW, Vederas JC, Tang Y, Tsai SC. Crystal structure and biochemical studies of the trans-acting polyketide enoyl reductase LovC from lovastatin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 11144-9. PMID 22733743 DOI: 10.1073/Pnas.1113029109 |
0.799 |
|
| 2012 |
Lee MY, Ames BD, Tsai SC. Insight into the molecular basis of aromatic polyketide cyclization: crystal structure and in vitro characterization of WhiE-ORFVI. Biochemistry. 51: 3079-91. PMID 22432862 DOI: 10.1021/Bi201705Q |
0.817 |
|
| 2011 |
Ames BD, Lee MY, Moody C, Zhang W, Tang Y, Tsai SC. Structural and biochemical characterization of ZhuI aromatase/cyclase from the R1128 polyketide pathway. Biochemistry. 50: 8392-406. PMID 21870821 DOI: 10.1021/Bi200593M |
0.813 |
|
| 2011 |
Javidpour P, Das A, Khosla C, Tsai SC. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 50: 7426-39. PMID 21776967 DOI: 10.1021/Bi2006866 |
0.832 |
|
| 2011 |
Javidpour P, Korman TP, Shakya G, Tsai SC. Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase. Biochemistry. 50: 4638-49. PMID 21506596 DOI: 10.1021/Bi200335F |
0.788 |
|
| 2011 |
Gago G, Diacovich L, Arabolaza A, Tsai SC, Gramajo H. Fatty acid biosynthesis in actinomycetes. Fems Microbiology Reviews. 35: 475-97. PMID 21204864 DOI: 10.1111/J.1574-6976.2010.00259.X |
0.418 |
|
| 2010 |
Arabolaza A, Shillito ME, Lin TW, Diacovich L, Melgar M, Pham H, Amick D, Gramajo H, Tsai SC. Crystal structures and mutational analyses of acyl-CoA carboxylase beta subunit of Streptomyces coelicolor. Biochemistry. 49: 7367-76. PMID 20690600 DOI: 10.1021/Bi1005305 |
0.77 |
|
| 2010 |
Khakshoor O, Lin AJ, Korman TP, Sawaya MR, Tsai SC, Eisenberg D, Nowick JS. X-ray crystallographic structure of an artificial beta-sheet dimer. Journal of the American Chemical Society. 132: 11622-8. PMID 20669960 DOI: 10.1021/Ja103438W |
0.738 |
|
| 2010 |
Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC. Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 6246-51. PMID 20332208 DOI: 10.1073/Pnas.0913531107 |
0.806 |
|
| 2009 |
Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA. Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization. Nature. 461: 1139-43. PMID 19847268 DOI: 10.1038/Nature08475 |
0.802 |
|
| 2009 |
Kurth DG, Gago GM, de la Iglesia A, Bazet Lyonnet B, Lin TW, Morbidoni HR, Tsai SC, Gramajo H. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria. Microbiology (Reading, England). 155: 2664-75. PMID 19423629 DOI: 10.1099/mic.0.027714-0 |
0.787 |
|
| 2009 |
Swamidass SJ, Azencott CA, Lin TW, Gramajo H, Tsai SC, Baldi P. Influence relevance voting: an accurate and interpretable virtual high throughput screening method. Journal of Chemical Information and Modeling. 49: 756-66. PMID 19391629 DOI: 10.1021/Ci8004379 |
0.748 |
|
| 2009 |
Tsai SC, Ames BD. Structural enzymology of polyketide synthases. Methods in Enzymology. 459: 17-47. PMID 19362634 DOI: 10.1016/S0076-6879(09)04602-3 |
0.789 |
|
| 2008 |
Smith P, Szu PH, Bui C, Liu HW, Tsai SC. Structure and mutagenic conversion of E1 dehydrase: at the crossroads of dehydration, amino transfer, and epimerization. Biochemistry. 47: 6329-41. PMID 18491919 DOI: 10.1021/bi702449p |
0.315 |
|
| 2008 |
Ames BD, Korman TP, Zhang W, Smith P, Vu T, Tang Y, Tsai SC. Crystal structure and functional analysis of tetracenomycin ARO/CYC: implications for cyclization specificity of aromatic polyketides. Proceedings of the National Academy of Sciences of the United States of America. 105: 5349-54. PMID 18388203 DOI: 10.1073/Pnas.0709223105 |
0.827 |
|
| 2008 |
Korman TP, Tan YH, Wong J, Luo R, Tsai SC. Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase. Biochemistry. 47: 1837-47. PMID 18205400 DOI: 10.1021/Bi7016427 |
0.81 |
|
| 2007 |
Smith S, Tsai SC. The type I fatty acid and polyketide synthases: a tale of two megasynthases. Natural Product Reports. 24: 1041-72. PMID 17898897 DOI: 10.1039/B603600G |
0.345 |
|
| 2006 |
Zhang W, Ames BD, Tsai SC, Tang Y. Engineered biosynthesis of a novel amidated polyketide, using the malonamyl-specific initiation module from the oxytetracycline polyketide synthase. Applied and Environmental Microbiology. 72: 2573-80. PMID 16597959 DOI: 10.1128/Aem.72.4.2573-2580.2006 |
0.747 |
|
| 2006 |
Lin TW, Melgar MM, Kurth D, Swamidass SJ, Purdon J, Tseng T, Gago G, Baldi P, Gramajo H, Tsai SC. Structure-based inhibitor design of AccD5, an essential acyl-CoA carboxylase carboxyltransferase domain of Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 3072-7. PMID 16492739 DOI: 10.1073/Pnas.0510580103 |
0.814 |
|
| 2006 |
Gago G, Kurth D, Diacovich L, Tsai SC, Gramajo H. Biochemical and structural characterization of an essential acyl coenzyme A carboxylase from Mycobacterium tuberculosis. Journal of Bacteriology. 188: 477-86. PMID 16385038 DOI: 10.1128/JB.188.2.477-486.2006 |
0.301 |
|
| 2005 |
Lin T, Mitchell D, Pham H, Tsai S. Engineering the substrate specificity and catalysis from crystal structures of the beta-subunit of Acyl-CoA carboxylase Acta Crystallographica Section a Foundations of Crystallography. 61: c228-c228. DOI: 10.1107/S0108767305090276 |
0.8 |
|
| 2004 |
Korman TP, Hill JA, Vu TN, Tsai SC. Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity. Biochemistry. 43: 14529-38. PMID 15544323 DOI: 10.1021/Bi048133A |
0.805 |
|
| 2004 |
Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. Crystal structure of the β-subunit of acyl-CoA carboxylase: Structure-based engineering of substrate specificity Biochemistry. 43: 14027-14036. PMID 15518551 DOI: 10.1021/Bi049065V |
0.545 |
|
| 2004 |
Tsai SC. A fine balancing act of type III polyketide synthase. Chemistry & Biology. 11: 1177-8. PMID 15380178 DOI: 10.1016/J.Chembiol.2004.09.001 |
0.396 |
|
| 2003 |
Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/J.Jmb.2003.10.021 |
0.44 |
|
| 2003 |
Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/Ja0378759 |
0.39 |
|
| 2003 |
Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2 |
0.374 |
|
| 2002 |
Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4 |
0.377 |
|
| 2002 |
Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 41: 12598-606. PMID 12379102 DOI: 10.1021/Bi0260177 |
0.416 |
|
| 2002 |
Lu H, Tsai SC, Khosla C, Cane DE. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 41: 12590-7. PMID 12379101 DOI: 10.1021/Bi026006D |
0.441 |
|
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