| Year |
Citation |
Score |
| 2024 |
Ghosh S, Dantuluri S, Jacewicz A, Sanchez AM, Abdullahu L, Damha MJ, Schwer B, Shuman S. Characterization of tRNA splicing enzymes RNA ligase and tRNA 2'-phosphotransferase from the pathogenic fungi . Rna (New York, N.Y.). PMID 38238085 DOI: 10.1261/rna.079911.123 |
0.414 |
|
| 2023 |
Engelbeen S, O'Reilly D, Van De Vijver D, Verhaart I, van Putten M, Hariharan V, Hassler M, Khvorova A, Damha MJ, Aartsma-Rus A. Challenges of Assessing Exon 53 Skipping of the Human Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy. Nucleic Acid Therapeutics. 33: 348-360. PMID 38010230 DOI: 10.1089/nat.2023.0038 |
0.788 |
|
| 2023 |
El-Khoury R, Roman M, Assi HA, Moye AL, Bryan TM, Damha MJ. Telomeric i-motifs and C-strands inhibit parallel G-quadruplex extension by telomerase. Nucleic Acids Research. PMID 37742080 DOI: 10.1093/nar/gkad764 |
0.76 |
|
| 2023 |
Clark NE, Katolik A, Gallant P, Welch A, Murphy E, Buerer L, Schorl C, Naik N, Naik MT, Holloway SP, Cano K, Weintraub ST, Howard KM, Hart PJ, Jogl G, ... Damha M, et al. Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain. The Journal of Biological Chemistry. 105100. PMID 37507019 DOI: 10.1016/j.jbc.2023.105100 |
0.309 |
|
| 2023 |
Buerer L, Clark N, Welch A, Duan C, Taggart A, Townley B, Wang J, Soemedi R, Rong S, Lin CL, Zeng Y, Katolik A, Staley J, Damha M, Mosammaparast N, et al. The debranching enzyme Dbr1 regulates lariat turnover and intron splicing. Research Square. PMID 37398028 DOI: 10.21203/rs.3.rs-2931976/v1 |
0.306 |
|
| 2023 |
Sudhakar S, Barkau CL, Chilamkurthy R, Barber HM, Pater AA, Moran SD, Damha MJ, Pradeepkumar PI, Gagnon KT. Binding to the Conserved and Stably Folded Guide RNA Pseudoknot Induces Cas12a Conformational Changes During Ribonucleoprotein Assembly. The Journal of Biological Chemistry. 104700. PMID 37059184 DOI: 10.1016/j.jbc.2023.104700 |
0.369 |
|
| 2022 |
Clark NE, Katolik A, Welch A, Schorl C, Holloway SP, Schuermann JP, Hart PJ, Taylor AB, Damha MJ, Fairbrother WG. Crystal Structure of the RNA Lariat Debranching Enzyme Dbr1 with Hydrolyzed Phosphorothioate RNA Product. Biochemistry. PMID 36484984 DOI: 10.1021/acs.biochem.2c00590 |
0.374 |
|
| 2022 |
Jana SK, Harikrishna S, Sudhakar S, El-Khoury R, Pradeepkumar PI, Damha MJ. Nucleoside Analogues with a Seven-Membered Sugar Ring: Synthesis and Structural Compatibility in DNA-RNA Hybrids. The Journal of Organic Chemistry. 87: 2367-2379. PMID 35133166 DOI: 10.1021/acs.joc.1c02254 |
0.461 |
|
| 2022 |
Corey DR, Damha MJ, Manoharan M. Challenges and Opportunities for Nucleic Acid Therapeutics. Nucleic Acid Therapeutics. 32: 8-13. PMID 34931905 DOI: 10.1089/nat.2021.0085 |
0.594 |
|
| 2021 |
Ageely EA, Chilamkurthy R, Jana S, Abdullahu L, O'Reilly D, Jensik PJ, Damha MJ, Gagnon KT. Gene editing with CRISPR-Cas12a guides possessing ribose-modified pseudoknot handles. Nature Communications. 12: 6591. PMID 34782635 DOI: 10.1038/s41467-021-26989-z |
0.832 |
|
| 2021 |
El-Khoury R, Damha MJ. 2'-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions. Accounts of Chemical Research. PMID 33861067 DOI: 10.1021/acs.accounts.1c00125 |
0.39 |
|
| 2021 |
Barkau CL, O'Reilly D, Eddington SB, Damha MJ, Gagnon KT. Small Nucleic Acids and the Path to the Clinic for Anti-CRISPR. Biochemical Pharmacology. 114492. PMID 33647260 DOI: 10.1016/j.bcp.2021.114492 |
0.659 |
|
| 2021 |
McKenzie LK, El-Khoury R, Thorpe JD, Damha MJ, Hollenstein M. Recent progress in non-native nucleic acid modifications. Chemical Society Reviews. PMID 33644787 DOI: 10.1039/d0cs01430c |
0.304 |
|
| 2021 |
Dantuluri S, Schwer B, Abdullahu L, Damha MJ, Shuman S. Activity and substrate specificity of , , and Tpt1: essential tRNA splicing enzymes and potential anti-fungal targets. Rna (New York, N.Y.). PMID 33509912 DOI: 10.1261/rna.078660.120 |
0.834 |
|
| 2020 |
Paudel BP, Moye AL, Abou Assi H, El-Khoury R, Cohen S, Holien JK, Birrento ML, Samosorn S, Intharapichai K, Tomlinson CG, Teulade-Fichou MP, González C, Beck JL, Damha MJ, van Oijen AM, et al. A mechanism for the extension and unfolding of parallel G-quadruplexes by human telomerase at single-molecule resolution. Elife. 9. PMID 32723475 DOI: 10.7554/Elife.56428 |
0.387 |
|
| 2020 |
Habibian M, Harikrishna S, Fakhoury J, Barton M, Ageely EA, Cencic R, Fakih HH, Katolik A, Takahashi M, Rossi J, Pelletier J, Gagnon KT, Pradeepkumar PI, Damha MJ. Effect of 2'-5'/3'-5' phosphodiester linkage heterogeneity on RNA interference. Nucleic Acids Research. PMID 32282904 DOI: 10.1093/Nar/Gkaa222 |
0.457 |
|
| 2020 |
Thorpe JD, O'Reilly D, Friscic T, Damha MJ. Mechanochemical synthesis of short DNA fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32166818 DOI: 10.1002/Chem.202001193 |
0.735 |
|
| 2020 |
Dantuluri S, Abdullahu L, Munir A, Katolik A, Damha MJ, Shuman S. Substrate analogs that trap the 2'-phospho-ADP-ribosylated RNA intermediate of the Tpt1 (tRNA 2'-phosphotransferase) reaction pathway. Rna (New York, N.Y.). PMID 31932322 DOI: 10.1261/Rna.074377.119 |
0.84 |
|
| 2020 |
Paudel BP, Moye AL, Assi HA, El-Khoury R, Cohen SB, Holien JK, Birrento ML, Samosorn S, Intharapichai K, Tomlinson CG, Teulade-Fichou M, González C, Beck JL, Damha MJ, Oijen AMv, et al. Author response: A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution Elife. DOI: 10.7554/Elife.56428.Sa2 |
0.733 |
|
| 2020 |
Thorpe JD, O'Reilly D, Friščić T, Damha MJ. Frontispiece: Mechanochemical Synthesis of Short DNA Fragments Chemistry: a European Journal. 26. DOI: 10.1002/Chem.202084163 |
0.345 |
|
| 2019 |
Lietard J, Damha MJ, Somoza MM. Large-Scale Photolithographic Synthesis of Chimeric DNA/RNA Hairpin Microarrays To Explore Sequence Specificity Landscapes of RNase HII Cleavage. Biochemistry. PMID 31631649 DOI: 10.1021/Acs.Biochem.9B00806 |
0.518 |
|
| 2019 |
Levi-Acobas F, Katolik A, Röthlisberger P, Cokelaer T, Sarac I, Damha MJ, Leumann CJ, Hollenstein M. Compatibility of 5-ethynyl-2'F-ANA UTP with in vitro selection for the generation of base-modified, nuclease resistant aptamers. Organic & Biomolecular Chemistry. PMID 31460550 DOI: 10.1039/C9Ob01515A |
0.379 |
|
| 2019 |
Takahashi M, Li H, Zhou J, Chomchan P, Aishwarya V, Damha MJ, Rossi JJ. Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy. Molecular Therapy. Nucleic Acids. 17: 615-625. PMID 31394430 DOI: 10.1016/J.Omtn.2019.07.001 |
0.34 |
|
| 2019 |
Malek-Adamian E, Fakhoury J, Arnold AE, Martínez-Montero S, Shoichet MS, Damha MJ. Effect of Sugar 2',4'-Modifications on Gene Silencing Activity of Small Interfering RNA Duplexes. Nucleic Acid Therapeutics. PMID 31084536 DOI: 10.1089/Nat.2019.0792 |
0.369 |
|
| 2019 |
Munir A, Abdullahu L, Banerjee A, Damha MJ, Shuman S. NAD-dependent RNA terminal 2' and 3' phosphomonoesterase activity of a sub-set of Tpt1 enzymes. Rna (New York, N.Y.). PMID 31019096 DOI: 10.1261/Rna.071142.119 |
0.836 |
|
| 2019 |
Barkau CL, O'Reilly D, Rohilla KJ, Damha MJ, Gagnon KT. Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9. Nucleic Acid Therapeutics. PMID 30990769 DOI: 10.1089/Nat.2018.0758 |
0.755 |
|
| 2019 |
Banerjee A, Munir A, Abdullahu L, Damha MJ, Goldgur Y, Shuman S. Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO recognition and ADP-ribosylation. Nature Communications. 10: 218. PMID 30644400 DOI: 10.1038/s41467-018-08211-9 |
0.838 |
|
| 2018 |
O'Reilly D, Kartje ZJ, Ageely EA, Malek-Adamian E, Habibian M, Schofield A, Barkau CL, Rohilla KJ, DeRossett LB, Weigle AT, Damha MJ, Gagnon KT. Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity. Nucleic Acids Research. PMID 30517736 DOI: 10.1093/Nar/Gky1214 |
0.769 |
|
| 2018 |
Lietard J, Ameur D, Damha MJ, Somoza MM. High-Density RNA Microarrays Synthesized In Situ by Photolithography. Angewandte Chemie (International Ed. in English). PMID 30187993 DOI: 10.1002/Anie.201806895 |
0.546 |
|
| 2018 |
O'Reilly D, Stein RS, Burai Patrascu M, Jana SK, Kurian J, Moitessier N, Damha MJ. Exploring atypical fluorine-hydrogen bonds and their effects on nucleoside conformations. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30125398 DOI: 10.1002/Chem.201803940 |
0.668 |
|
| 2018 |
Abou Assi H, Garavís M, González C, Damha MJ. i-Motif DNA: structural features and significance to cell biology. Nucleic Acids Research. PMID 30124962 DOI: 10.1093/Nar/Gky735 |
0.354 |
|
| 2018 |
Shen X, Kilikevicius A, O'Reilly D, Prakash TP, Damha MJ, Rigo F, Corey DR. Activating frataxin expression by single-stranded siRNAs targeting the GAA repeat expansion. Bioorganic & Medicinal Chemistry Letters. PMID 30076049 DOI: 10.1016/J.Bmcl.2018.07.033 |
0.774 |
|
| 2018 |
Malek-Adamian E, Patrascu MB, Jana SK, Martinez-Montero S, Moitessier N, Damha MJ. Adjusting the Structure of 2'-Modified Nucleosides and Oligonucleotides via C4'-α-F or C4'-α-OMe Substitution: Synthesis and Conformational Analysis. The Journal of Organic Chemistry. PMID 29963864 DOI: 10.1021/Acs.Joc.8B01329 |
0.36 |
|
| 2018 |
Vlaho D, Damha MJ. Synthesis of Chimeric Oligonucleotides Having Modified Internucleotide Linkages via an Automated H-Phosphonate/Phosphoramidite Approach. Current Protocols in Nucleic Acid Chemistry. 73: e53. PMID 29927099 DOI: 10.1002/Cpnc.53 |
0.341 |
|
| 2018 |
Munir A, Abdullahu L, Damha M, Shuman S. Two-step mechanism and step-arrest mutants of Runella slithyformis NAD-dependent tRNA 2'-phosphotransferase Tpt1. Rna (New York, N.Y.). PMID 29884622 DOI: 10.1261/Rna.067165.118 |
0.816 |
|
| 2018 |
Zhang SY, Clark NE, Freije CA, Pauwels E, Taggart AJ, Okada S, Mandel H, Garcia P, Ciancanelli MJ, Biran A, Lafaille FG, Tsumura M, Cobat A, Luo J, Volpi S, ... ... Damha MJ, et al. Inborn Errors of RNA Lariat Metabolism in Humans with Brainstem Viral Infection. Cell. 172: 952-965.e18. PMID 29474921 DOI: 10.1016/J.Cell.2018.02.019 |
0.373 |
|
| 2018 |
Habibian M, Yahyaee-Anzahaee M, Lucic M, Moroz E, Martín-Pintado N, Di Giovanni LD, Leroux JC, Hall J, González C, Damha MJ. Structural properties and gene-silencing activity of chemically modified DNA-RNA hybrids with parallel orientation. Nucleic Acids Research. PMID 29373740 DOI: 10.1093/Nar/Gky024 |
0.52 |
|
| 2018 |
Li L, Shen X, Liu Z, Norrbom M, Prakash TP, O'Reilly D, Sharma VK, Damha MJ, Watts JK, Rigo F, Corey DR. Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat. Nucleic Acid Therapeutics. PMID 29341839 DOI: 10.1089/Nat.2017.0703 |
0.789 |
|
| 2017 |
Vlaho D, Fakhoury JF, Damha MJ. Structural Studies and Gene Silencing Activity of siRNAs Containing Cationic Phosphoramidate Linkages. Nucleic Acid Therapeutics. PMID 29195060 DOI: 10.1089/nat.2017.0702 |
0.358 |
|
| 2017 |
Abou Assi H, Lin YC, Serrano I, Gonzalez C, Damha MJ. Probing synergistic effects of DNA methylation and 2'-β-fluorination on i-motif stability. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29096420 DOI: 10.1002/Chem.201704591 |
0.323 |
|
| 2017 |
Assi HA, El-Khoury R, González C, Damha MJ. 2'-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA. Nucleic Acids Research. PMID 29040679 DOI: 10.1093/Nar/Gkx962 |
0.757 |
|
| 2017 |
Malek-Adamian E, Guenther D, Matsuda S, Martínez-Montero S, Zlatev I, Harp J, Burai Patrascu M, Foster DJ, Fakhoury JJ, Perkins L, Moitessier N, Manoharan R, Taneja N, Bisbe A, Charisse K, ... ... Damha MJ, et al. 4'-C-Methoxy-2'-Deoxy-2'-Fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing. Journal of the American Chemical Society. PMID 28937776 DOI: 10.1021/Jacs.7B07582 |
0.338 |
|
| 2017 |
Burai Patrascu M, Malek-Adamian E, Damha MJ, Moitessier N. Accurately Modeling the Conformational Preferences of Nucleosides. Journal of the American Chemical Society. PMID 28899099 DOI: 10.1021/Jacs.7B07436 |
0.338 |
|
| 2017 |
Abbas YM, Laudenbach BT, Martínez-Montero S, Cencic R, Habjan M, Pichlmair A, Damha MJ, Pelletier J, Nagar B. Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. Proceedings of the National Academy of Sciences of the United States of America. PMID 28251928 DOI: 10.1073/Pnas.1612444114 |
0.471 |
|
| 2017 |
Lietard J, Abou Assi H, Gómez-Pinto I, González C, Somoza MM, Damha MJ. Mapping the affinity landscape of Thrombin-binding aptamers on 2'F-ANA/DNA chimeric G-Quadruplex microarrays. Nucleic Acids Research. PMID 28100695 DOI: 10.1093/Nar/Gkw1357 |
0.392 |
|
| 2017 |
Katolik A, Clark NE, Tago N, Montemayor EJ, Hart PJ, Damha MJ. Fluorescent Branched RNAs for High-Throughput Analysis of Dbr1 Enzyme Kinetics and Inhibition. Acs Chemical Biology. PMID 28055181 DOI: 10.1021/Acschembio.6B00971 |
0.433 |
|
| 2017 |
Lietard J, Assi HA, Gomez-Pinto I, Gonzalez C, Somoza MM, Damha MJ. 2'F-ANA/DNA Chimeric TBA Quadruplex structure Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb5Mjx/Pdb |
0.305 |
|
| 2016 |
Clark NE, Katolik A, Roberts KM, Taylor AB, Holloway SP, Schuermann JP, Montemayor EJ, Stevens SW, Fitzpatrick PF, Damha MJ, Hart PJ. Metal dependence and branched RNA cocrystal structures of the RNA lariat debranching enzyme Dbr1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27930312 DOI: 10.1073/Pnas.1612729114 |
0.451 |
|
| 2016 |
Hollenstein M, Damha MJ. Rolling Circle Amplification with Chemically Modified Nucleoside Triphosphates. Current Protocols in Nucleic Acid Chemistry. 67: 7.26.1-7.26.15. PMID 27911492 DOI: 10.1002/Cpnc.17 |
0.386 |
|
| 2016 |
Moroz E, Lee SH, Yamada K, Halloy F, Martínez-Montero S, Jahns H, Hall J, Damha MJ, Castagner B, Leroux JC. Carrier-free Gene Silencing by Amphiphilic Nucleic Acid Conjugates in Differentiated Intestinal Cells. Molecular Therapy. Nucleic Acids. 5: e364. PMID 27648924 DOI: 10.1038/Mtna.2016.69 |
0.305 |
|
| 2016 |
Assi HA, Harkness RW, Martin-Pintado N, Wilds CJ, Campos-Olivas R, Mittermaier AK, González C, Damha MJ. Stabilization of i-motif structures by 2'-β-fluorination of DNA. Nucleic Acids Research. PMID 27166371 DOI: 10.1093/Nar/Gkw402 |
0.785 |
|
| 2016 |
Kulkarni AS, Damha MJ, Schinazi RF, Mo H, Doehle B, Sagan SM, Götte M. A complex network of interactions between S282 and G283 of HCV NS5B and the template strand affect susceptibility to Sofosbuvir and Ribavirin. Antimicrobial Agents and Chemotherapy. PMID 26824949 DOI: 10.1128/Aac.02436-15 |
0.379 |
|
| 2016 |
Abou-Assi R, Harkness R, Martin-Pintado N, Wilds C, Campos-Olivas R, Mittermaier A, Gonzalez C, Damha M. Tetrameric i-motif structure of dT-dC-dC-CFL-CFL-dC at acidic pH Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr25840 |
0.584 |
|
| 2016 |
Takahashi M, Li H, Aishwarya V, Damha MJ, Rossi JJ. 586. Dimerization Inhibition of HIV-1 RNA by 2’-Deoxy-2’-fluoro-beta-D-arabinose Nucleic Acid (2’-FANA) Modified Antisense Oligonucleotides Results in Potential Inhibition of Viral Expression Molecular Therapy. 24: S232-S233. DOI: 10.1016/S1525-0016(16)33394-9 |
0.441 |
|
| 2015 |
Habibian M, Martínez-Montero S, Portella G, Chua Z, Bohle DS, Orozco M, Damha MJ. Seven-Membered Ring Nucleoside Analogues: Stereoselective Synthesis and Studies on Their Conformational Properties. Organic Letters. 17: 5416-9. PMID 26492193 DOI: 10.1021/Acs.Orglett.5B02769 |
0.329 |
|
| 2015 |
Tago N, Katolik A, Clark NE, Montemayor EJ, Seio K, Sekine M, Hart PJ, Damha MJ. Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme. The Journal of Organic Chemistry. 80: 10108-18. PMID 26378468 DOI: 10.1021/Acs.Joc.5B01719 |
0.551 |
|
| 2015 |
Yamada K, Wahba AS, Bernatchez JA, Ilina T, Martínez-Montero S, Habibian M, Deleavey GF, Götte M, Parniak MA, Damha MJ. Nucleotide Sugar Pucker Preference Mitigates Excision by HIV-1 RT. Acs Chemical Biology. 10: 2024-33. PMID 26131619 DOI: 10.1021/Acschembio.5B00263 |
0.355 |
|
| 2015 |
Martínez-Montero S, Deleavey GF, Martín-Pintado N, Fakhoury JF, González C, Damha MJ. Locked 2'-Deoxy-2',4'-Difluororibo Modified Nucleic Acids: Thermal Stability, Structural Studies, and siRNA Activity. Acs Chemical Biology. PMID 26053215 DOI: 10.1021/Acschembio.5B00218 |
0.558 |
|
| 2015 |
Martínez-Montero S, Deleavey GF, Dierker-Viik A, Lindovska P, Ilina T, Portella G, Orozco M, Parniak MA, González C, Damha MJ. Synthesis and properties of 2'-deoxy-2',4'-difluoroarabinose-modified nucleic acids. The Journal of Organic Chemistry. 80: 3083-91. PMID 25723361 DOI: 10.1021/Jo502948T |
0.526 |
|
| 2015 |
Abou Assi H, Martínez-Montero S, Dixit DM, Chua Z, Bohle DS, Damha MJ. Synthesis, structure, and conformational analysis of nucleoside analogues comprising six-membered 1,3-oxathiane sugar rings European Journal of Organic Chemistry. 2015: 1945-1953. DOI: 10.1002/Ejoc.201403642 |
0.312 |
|
| 2014 |
Lietard J, Hassler MR, Fakhoury J, Damha MJ. An orthogonal photolabile linker for the complete "on-support" synthesis/fast deprotection/hybridization of RNA. Chemical Communications (Cambridge, England). 50: 15063-6. PMID 25329642 DOI: 10.1039/C4Cc07153K |
0.517 |
|
| 2014 |
Lietard J, Kretschy N, Sack M, Wahba AS, Somoza MM, Damha MJ. Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography. Chemical Communications (Cambridge, England). 50: 12903-6. PMID 25213224 DOI: 10.1039/C4Cc05771F |
0.495 |
|
| 2014 |
Anzahaee MY, Deleavey GF, Le PU, Fakhoury J, Petrecca K, Damha MJ. Arabinonucleic acids: 2'-stereoisomeric modulators of siRNA activity. Nucleic Acid Therapeutics. 24: 336-43. PMID 25162466 DOI: 10.1089/nat.2014.0496 |
0.424 |
|
| 2014 |
Montemayor EJ, Katolik A, Clark NE, Taylor AB, Schuermann JP, Combs DJ, Johnsson R, Holloway SP, Stevens SW, Damha MJ, Hart PJ. Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1. Nucleic Acids Research. 42: 10845-55. PMID 25123664 DOI: 10.1093/Nar/Gku725 |
0.496 |
|
| 2014 |
Garrey SM, Katolik A, Prekeris M, Li X, York K, Bernards S, Fields S, Zhao R, Damha MJ, Hesselberth JR. A homolog of lariat-debranching enzyme modulates turnover of branched RNA. Rna (New York, N.Y.). 20: 1337-48. PMID 24919400 DOI: 10.1261/Rna.044602.114 |
0.489 |
|
| 2014 |
Martínez-Montero S, Deleavey GF, Kulkarni A, Martín-Pintado N, Lindovska P, Thomson M, González C, Götte M, Damha MJ. Rigid 2',4'-difluororibonucleosides: synthesis, conformational analysis, and incorporation into nascent RNA by HCV polymerase. The Journal of Organic Chemistry. 79: 5627-35. PMID 24873952 DOI: 10.1021/Jo500794V |
0.505 |
|
| 2014 |
Johnsson RA, Bogojeski JJ, Damha MJ. An evaluation of selective deprotection conditions for the synthesis of RNA on a light labile solid support. Bioorganic & Medicinal Chemistry Letters. 24: 2146-9. PMID 24698549 DOI: 10.1016/J.Bmcl.2014.03.032 |
0.376 |
|
| 2014 |
Katolik A, Johnsson R, Montemayor E, Lackey JG, Hart PJ, Damha MJ. Regiospecific solid-phase synthesis of branched oligoribonucleotides that mimic intronic lariat RNA intermediates. The Journal of Organic Chemistry. 79: 963-75. PMID 24401015 DOI: 10.1021/Jo4024182 |
0.533 |
|
| 2013 |
Martin-Pintado N, Deleavey GF, Portella G, Campos-Olivas R, Orozco M, Damha MJ, González C. Backbone FC-H···O hydrogen bonds in 2'F-substituted nucleic acids. Angewandte Chemie (International Ed. in English). 52: 12065-8. PMID 24115468 DOI: 10.1002/Anie.201305710 |
0.46 |
|
| 2013 |
Chan DPY, Deleavey GF, Owen SC, Damha MJ, Shoichet MS. Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery Biomaterials. 34: 8408-8415. PMID 23932248 DOI: 10.1016/J.Biomaterials.2013.07.019 |
0.392 |
|
| 2013 |
Martín-Pintado N, Yahyaee-Anzahaee M, Deleavey GF, Portella G, Orozco M, Damha MJ, González C. Dramatic effect of furanose C2' substitution on structure and stability: directing the folding of the human telomeric quadruplex with a single fluorine atom. Journal of the American Chemical Society. 135: 5344-7. PMID 23521511 DOI: 10.1021/Ja401954T |
0.329 |
|
| 2013 |
Deleavey GF, Frank F, Hassler M, Wisnovsky S, Nagar B, Damha MJ. The 5' binding MID domain of human Argonaute2 tolerates chemically modified nucleotide analogues. Nucleic Acid Therapeutics. 23: 81-7. PMID 23289589 DOI: 10.1089/Nat.2012.0393 |
0.559 |
|
| 2012 |
Souleimanian N, Deleavey GF, Soifer H, Wang S, Tiemann K, Damha MJ, Stein CA. Antisense 2'-Deoxy, 2'-Fluroarabino Nucleic Acids (2'F-ANAs) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids. Molecular Therapy. Nucleic Acids. 1: e43. PMID 23344235 DOI: 10.1038/Mtna.2012.35 |
0.35 |
|
| 2012 |
Deleavey GF, Damha MJ. Designing chemically modified oligonucleotides for targeted gene silencing. Chemistry & Biology. 19: 937-54. PMID 22921062 DOI: 10.1016/J.Chembiol.2012.07.011 |
0.358 |
|
| 2012 |
Martín-Pintado N, Yahyaee-Anzahaee M, Campos-Olivas R, Noronha AM, Wilds CJ, Damha MJ, González C. The solution structure of double helical arabino nucleic acids (ANA and 2'F-ANA): effect of arabinoses in duplex-hairpin interconversion. Nucleic Acids Research. 40: 9329-39. PMID 22798499 DOI: 10.1093/Nar/Gks672 |
0.66 |
|
| 2012 |
Felber AE, Bayó-Puxan N, Deleavey GF, Castagner B, Damha MJ, Leroux JC. The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity. Biomaterials. 33: 5955-65. PMID 22656448 DOI: 10.1016/J.Biomaterials.2012.05.019 |
0.354 |
|
| 2011 |
Wahba AS, Azizi F, Deleavey GF, Brown C, Robert F, Carrier M, Kalota A, Gewirtz AM, Pelletier J, Hudson RH, Damha MJ. Phenylpyrrolocytosine as an unobtrusive base modification for monitoring activity and cellular trafficking of siRNA. Acs Chemical Biology. 6: 912-9. PMID 21667942 DOI: 10.1021/Cb200070K |
0.653 |
|
| 2011 |
Johnsson R, Lackey JG, Bogojeski JJ, Damha MJ. New light labile linker for solid phase synthesis of 2'-O-acetalester oligonucleotides and applications to siRNA prodrug development. Bioorganic & Medicinal Chemistry Letters. 21: 3721-5. PMID 21570286 DOI: 10.1016/J.Bmcl.2011.04.073 |
0.371 |
|
| 2011 |
Felber AE, Castagner B, Elsabahy M, Deleavey GF, Damha MJ, Leroux JC. siRNA nanocarriers based on methacrylic acid copolymers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 152: 159-67. PMID 21195736 DOI: 10.1016/J.Jconrel.2010.12.012 |
0.363 |
|
| 2011 |
Anzahaee MY, Watts JK, Alla NR, Nicholson AW, Damha MJ. Energetically important C-H···F-C pseudohydrogen bonding in water: evidence and application to rational design of oligonucleotides with high binding affinity. Journal of the American Chemical Society. 133: 728-31. PMID 21171597 DOI: 10.1021/Ja109817P |
0.59 |
|
| 2011 |
Hassler M, Wu YQ, Mallikarjuna Reddy N, Chan TH, Damha MJ. RNA synthesis via dimer and trimer phosphoramidite block coupling Tetrahedron Letters. 52: 2575-2578. DOI: 10.1016/J.Tetlet.2011.03.042 |
0.442 |
|
| 2010 |
Gagnon KT, Pendergraff HM, Deleavey GF, Swayze EE, Potier P, Randolph J, Roesch EB, Chattopadhyaya J, Damha MJ, Bennett CF, Montaillier C, Lemaitre M, Corey DR. Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry. 49: 10166-78. PMID 21028906 DOI: 10.1021/Bi101208K |
0.563 |
|
| 2010 |
Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research. 38: 4547-57. PMID 20413581 DOI: 10.1093/Nar/Gkq181 |
0.737 |
|
| 2010 |
Watts JK, Martín-Pintado N, Gómez-Pinto I, Schwartzentruber J, Portella G, Orozco M, González C, Damha MJ. Differential stability of 2'F-ANA*RNA and ANA*RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility. Nucleic Acids Research. 38: 2498-511. PMID 20071751 DOI: 10.1093/Nar/Gkp1225 |
0.694 |
|
| 2010 |
Wahba AS, Esmaeili A, Damha MJ, Hudson RH. A single-label phenylpyrrolocytidine provides a molecular beacon-like response reporting HIV-1 RT RNase H activity. Nucleic Acids Research. 38: 1048-56. PMID 19933258 DOI: 10.1093/Nar/Gkp1022 |
0.684 |
|
| 2010 |
DAMHA MJ, OGILVIE KK. ChemInform Abstract: Oligoribonucleotide Synthesis. The Silyl-Phosphoramidite Method Cheminform. 25: no-no. DOI: 10.1002/chin.199410299 |
0.482 |
|
| 2010 |
DAMHA MJ, GUO Y, ZABARYLO SV, GANESHAN K, GIANNARIS PA. ChemInform Abstract: Tricyclic “Oxadiazaphosphorine Oxide” Guanosines: A New Strategy to the Protection of Guanine Bases During RNA Synthesis. Cheminform. 24: no-no. DOI: 10.1002/chin.199316138 |
0.408 |
|
| 2009 |
Deleavey GF, Watts JK, Damha MJ. Chemical modification of siRNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 16.3. PMID 20013783 DOI: 10.1002/0471142700.Nc1603S39 |
0.698 |
|
| 2009 |
Watts JK, Katolik A, Viladoms J, Damha MJ. Studies on the hydrolytic stability of 2'-fluoroarabinonucleic acid (2'F-ANA). Organic & Biomolecular Chemistry. 7: 1904-10. PMID 19590787 DOI: 10.1039/B900443B |
0.71 |
|
| 2009 |
Lackey JG, Mitra D, Somoza MM, Cerrina F, Damha MJ. Acetal levulinyl ester (ALE) groups for 2'-hydroxyl protection of ribonucleosides in the synthesis of oligoribonucleotides on glass and microarrays. Journal of the American Chemical Society. 131: 8496-502. PMID 19485360 DOI: 10.1021/Ja9002074 |
0.42 |
|
| 2009 |
Elsabahy M, Wazen N, Bayó-Puxan N, Deleavey G, Servant M, Damha MJ, Leroux J. Delivery of Nucleic Acids through the Controlled Disassembly of Multifunctional Nanocomplexes Advanced Functional Materials. 19: 3862-3867. DOI: 10.1002/Adfm.200901139 |
0.351 |
|
| 2008 |
Lackey JG, Ron D, Damha MJ, Harding HP. Toward the discovery of new antifungal agents: the design and validation of a novel 2'P-RNA probe and high throughput screening assay against 2'-phosphotransferase Tpt1p. Nucleic Acids Symposium Series (2004). 475-6. PMID 18776460 DOI: 10.1093/nass/nrn241 |
0.352 |
|
| 2008 |
Wahba AS, Damha MJ, Hudson RH. RNA containing pyrrolocytidine base analogs: good binding affinity and fluorescence that responds to hybridization. Nucleic Acids Symposium Series (2004). 399-400. PMID 18776422 DOI: 10.1093/nass/nrn203 |
0.662 |
|
| 2008 |
Wahba AS, Damha MJ, Hudson RH. RNA containing pyrrolocytidine base analogs: increased binding affinity and fluorescence that responds to hybridization. Nucleic Acids Symposium Series (2004). 397-8. PMID 18776421 DOI: 10.1093/nass/nrn202 |
0.686 |
|
| 2008 |
Watts JK, Deleavey GF, Damha MJ. Chemically modified siRNA: tools and applications. Drug Discovery Today. 13: 842-55. PMID 18614389 DOI: 10.1016/J.Drudis.2008.05.007 |
0.653 |
|
| 2008 |
Watts JK, Johnston BD, Jayakanthan K, Wahba AS, Pinto BM, Damha MJ. Synthesis and biophysical characterization of oligonucleotides containing a 4'-selenonucleotide. Journal of the American Chemical Society. 130: 8578-9. PMID 18543920 DOI: 10.1021/Ja802205U |
0.707 |
|
| 2008 |
Harding HP, Lackey JG, Hsu HC, Zhang Y, Deng J, Xu RM, Damha MJ, Ron D. An intact unfolded protein response in Trpt1 knockout mice reveals phylogenic divergence in pathways for RNA ligation. Rna (New York, N.Y.). 14: 225-32. PMID 18094117 DOI: 10.1261/Rna.859908 |
0.479 |
|
| 2008 |
Peng CG, Damha MJ. Probing DNA polymerase activity with stereoisomeric 2′-fluoro-β-D-arabinose (2′F-araNTPs) and 2′-fluoro-β-D-ribose (2′F-rNTPs) nucleoside 5′-triphosphates Canadian Journal of Chemistry. 86: 881-891. DOI: 10.1139/V08-089 |
0.393 |
|
| 2008 |
Watts JK, Damha MJ. 2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers Canadian Journal of Chemistry. 86: 641-656. DOI: 10.1139/V08-049 |
0.451 |
|
| 2007 |
Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Mario Pinto B, Damha MJ. 2'-Fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-1451. PMID 28383739 DOI: 10.1093/nar/gkl1153 |
0.701 |
|
| 2007 |
Donga RA, Hassler M, Chan TH, Damha MJ. Oligonucleotide synthesis using ionic liquids as soluble supports. Nucleosides, Nucleotides & Nucleic Acids. 26: 1287-93. PMID 18066770 DOI: 10.1080/15257770701530533 |
0.308 |
|
| 2007 |
Peng CG, Damha MJ. DNA polymerase recognition of 2'-deoxy-2'-fluoroarabinonucleoside 5'-triphosphates (2'F-araNTPs). Nucleosides, Nucleotides & Nucleic Acids. 26: 1189-93. PMID 18058563 DOI: 10.1080/15257770701527786 |
0.383 |
|
| 2007 |
Sabatino D, Damha MJ. Synthesis and properties of oligonucleotides containing a 7-membered (oxepane) sugar ring. Nucleosides, Nucleotides & Nucleic Acids. 26: 1185-8. PMID 18058562 DOI: 10.1080/15257770701527760 |
0.746 |
|
| 2007 |
Mitra D, Damha MJ. A novel approach to the synthesis of DNA and RNA lariats. The Journal of Organic Chemistry. 72: 9491-500. PMID 17979285 DOI: 10.1021/Jo701418W |
0.58 |
|
| 2007 |
Peng CG, Damha MJ. G-quadruplex induced stabilization by 2'-deoxy-2'-fluoro-D-arabinonucleic acids (2'F-ANA). Nucleic Acids Research. 35: 4977-88. PMID 17636049 DOI: 10.1093/Nar/Gkm520 |
0.364 |
|
| 2007 |
Sabatino D, Damha MJ. Oxepane nucleic acids: synthesis, characterization, and properties of oligonucleotides bearing a seven-membered carbohydrate ring. Journal of the American Chemical Society. 129: 8259-70. PMID 17559214 DOI: 10.1021/Ja071336C |
0.777 |
|
| 2007 |
Peng CG, Damha MJ. Polymerase-directed synthesis of 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acids. Journal of the American Chemical Society. 129: 5310-1. PMID 17419631 DOI: 10.1021/Ja069100G |
0.39 |
|
| 2007 |
Pâtureau BM, Hudson RH, Damha MJ. Induction of RNase H activity by Arabinose-peptide nucleic acid chimeras. Bioconjugate Chemistry. 18: 421-30. PMID 17373768 DOI: 10.1021/Bc060300R |
0.744 |
|
| 2007 |
Watts JK, Choubdar N, Sadalapure K, Robert F, Wahba AS, Pelletier J, Pinto BM, Damha MJ. 2'-fluoro-4'-thioarabino-modified oligonucleotides: conformational switches linked to siRNA activity. Nucleic Acids Research. 35: 1441-51. PMID 17284457 DOI: 10.1093/Nar/Gkl1153 |
0.729 |
|
| 2007 |
Lackey JG, Sabatino D, Damha MJ. Solid-phase synthesis and on-column deprotection of RNA from 2'- (and 3'-) O-levulinated (Lv) ribonucleoside monomers. Organic Letters. 9: 789-92. PMID 17279762 DOI: 10.1021/Ol0629521 |
0.726 |
|
| 2007 |
Donga RA, Chan T, Damha MJ. Ion-tagged synthesis of an oligoribonucleotide pentamer — The continuing versatility of TBDMS chemistry Canadian Journal of Chemistry. 85: 274-282. DOI: 10.1139/V07-022 |
0.411 |
|
| 2006 |
Opalinska JB, Kalota A, Chattopadhyaya J, Damha M, Gewirtz AM. Nucleic acid therapeutics for hematologic malignancies--theoretical considerations. Annals of the New York Academy of Sciences. 1082: 124-36. PMID 17145934 DOI: 10.1196/Annals.1348.002 |
0.43 |
|
| 2006 |
Ferrari N, Bergeron D, Tedeschi AL, Mangos MM, Paquet L, Renzi PM, Damha MJ. Characterization of antisense oligonucleotides comprising 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA): specificity, potency, and duration of activity. Annals of the New York Academy of Sciences. 1082: 91-102. PMID 17145930 DOI: 10.1196/Annals.1348.032 |
0.456 |
|
| 2006 |
Donga RA, Khaliq-Uz-Zaman SM, Chan TH, Damha MJ. A novel approach to oligonucleotide synthesis using an imidazolium ion tag as a soluble support. The Journal of Organic Chemistry. 71: 7907-10. PMID 16995711 DOI: 10.1021/Jo061279Q |
0.324 |
|
| 2006 |
Dowler T, Bergeron D, Tedeschi AL, Paquet L, Ferrari N, Damha MJ. Improvements in siRNA properties mediated by 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (FANA). Nucleic Acids Research. 34: 1669-75. PMID 16554553 DOI: 10.1093/Nar/Gkl033 |
0.529 |
|
| 2006 |
Mourani R, Damha MJ. Synthesis, characterization, and biological properties of small branched RNA fragments containing chiral (Rp and Sp) 2',5'-phosphorothioate linkages. Nucleosides, Nucleotides & Nucleic Acids. 25: 203-29. PMID 16541962 DOI: 10.1080/15257770500447004 |
0.503 |
|
| 2006 |
Watts JK, Sadalapure K, Choubdar N, Pinto BM, Damha MJ. Synthesis and conformational analysis of 2'-fluoro-5-methyl-4'-thioarabinouridine (4'S-FMAU). The Journal of Organic Chemistry. 71: 921-5. PMID 16438502 DOI: 10.1021/Jo051844+ |
0.598 |
|
| 2006 |
Kalota A, Karabon L, Swider CR, Viazovkina E, Elzagheid M, Damha MJ, Gewirtz AM. 2'-deoxy-2'-fluoro-beta-D-arabinonucleic acid (2'F-ANA) modified oligonucleotides (ON) effect highly efficient, and persistent, gene silencing. Nucleic Acids Research. 34: 451-61. PMID 16421272 DOI: 10.1093/Nar/Gkj455 |
0.405 |
|
| 2006 |
Gendron D, Carriero S, Garneau D, Villemaire J, Klinck R, Elela SA, Damha MJ, Chabot B. Modulation of 5' splice site selection using tailed oligonucleotides carrying splicing signals. Bmc Biotechnology. 6: 5. PMID 16412215 DOI: 10.1186/1472-6750-6-5 |
0.8 |
|
| 2005 |
Hannoush RN, Damha MJ. Preference for ribose over deoxyribose in loop-closing base pairs of extra stable nucleic acid hairpins. Nucleosides, Nucleotides & Nucleic Acids. 24: 1519-30. PMID 16438032 DOI: 10.1080/15257770500265794 |
0.484 |
|
| 2005 |
Peng CG, Damha MJ. Synthesis and hybridization studies of oligonucleotides containing 1-(2-deoxy-2-alpha-C-hydroxymethyl-beta-D-ribofuranosyl)thymine (2'-alpha-hm-dT). Nucleic Acids Research. 33: 7019-28. PMID 16377780 DOI: 10.1093/Nar/Gki1003 |
0.541 |
|
| 2005 |
Khalid MF, Damha MJ, Shuman S, Schwer B. Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic Acids Research. 33: 6349-60. PMID 16275784 DOI: 10.1093/Nar/Gki934 |
0.526 |
|
| 2005 |
Galarneau A, Min KL, Mangos MM, Damha MJ. Assay for evaluating ribonuclease H-mediated degradation of RNA-antisense oligonucleotide duplexes. Methods in Molecular Biology (Clifton, N.J.). 288: 65-80. PMID 15333898 DOI: 10.1385/1-59259-823-4:065 |
0.519 |
|
| 2005 |
Kalota A, Karabon L, Swider CS, Viazovkina E, Elzagheid M, Damha MJ, Gewirtz AM. A Novel 2′-Deoxy-2′-Fluoro (2′F-ANA) Ribose Modification Significantly Enhances the Duration, and Efficiency, of Nucleic Acid Mediated Gene Silencing. Blood. 106: 3062-3062. DOI: 10.1182/Blood.V106.11.3062.3062 |
0.438 |
|
| 2004 |
Hannoush RN, Min KL, Damha MJ. Diversity-oriented solid-phase synthesis and biological evaluation of oligonucleotide hairpins as HIV-1 RT RNase H inhibitors. Nucleic Acids Research. 32: 6164-75. PMID 15570067 DOI: 10.1093/Nar/Gkh948 |
0.456 |
|
| 2004 |
Hannoush RN, Carriero S, Min KL, Damha MJ. Selective inhibition of HIV-1 reverse transcriptase (HIV-1 RT) RNase H by small RNA hairpins and dumbbells. Chembiochem : a European Journal of Chemical Biology. 5: 527-33. PMID 15185377 DOI: 10.1002/Cbic.200300831 |
0.806 |
|
| 2004 |
Lamontagne B, Hannoush RN, Damha MJ, Abou Elela S. Molecular requirements for duplex recognition and cleavage by eukaryotic RNase III: discovery of an RNA-dependent DNA cleavage activity of yeast Rnt1p. Journal of Molecular Biology. 338: 401-18. PMID 15066440 DOI: 10.1016/J.Jmb.2004.02.059 |
0.553 |
|
| 2004 |
Agha KA, Damha MJ. Synthesis and Binding Properties of a Homopyrimidine 2′,5′-Linked Xylose Nucleic Acid (2′,5′-XNA) Cheminform. 35. DOI: 10.1002/chin.200407202 |
0.783 |
|
| 2003 |
Carriero S, Damha MJ. Inhibition of pre-mRNA splicing by synthetic branched nucleic acids. Nucleic Acids Research. 31: 6157-67. PMID 14576302 DOI: 10.1093/Nar/Gkg824 |
0.828 |
|
| 2003 |
Carriero S, Damha MJ. Template-mediated synthesis of lariat RNA and DNA. The Journal of Organic Chemistry. 68: 8328-38. PMID 14575454 DOI: 10.1021/Jo035002R |
0.852 |
|
| 2003 |
Hannoush RN, Denisov AY, Gehring K, Damha MJ. Structure of 2',5'-linked tetraribonucleotide loops: a novel RNA motif. Nucleosides, Nucleotides & Nucleic Acids. 22: 1687-90. PMID 14565496 DOI: 10.1081/Ncn-120023114 |
0.486 |
|
| 2003 |
Carriero S, Mangos MM, Agha KA, Noronha AM, Damha MJ. Branchpoint sugar stereochemistry determines the hydrolytic susceptibility of branched RNA fragments by the yeast debranching enzyme (YDBR). Nucleosides, Nucleotides & Nucleic Acids. 22: 1599-602. PMID 14565475 DOI: 10.1081/Ncn-120023043 |
0.805 |
|
| 2003 |
Elzagheid MI, Tedeschi AL, Damha MJ. Synthesis of 2',3'-dideoxy-2'-fluoro-3'-thioarabinothymidine and its 3'-phosphoramidite derivative. Nucleosides, Nucleotides & Nucleic Acids. 22: 1343-6. PMID 14565414 DOI: 10.1081/Ncn-120022961 |
0.35 |
|
| 2003 |
Elzagheid MI, Viazovkina E, Damha MJ. A new synthesis of 9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)guanine (AraF-G). Nucleosides, Nucleotides & Nucleic Acids. 22: 1339-42. PMID 14565413 DOI: 10.1081/Ncn-120022960 |
0.313 |
|
| 2003 |
Viazovkina E, Min KL, Galarneau A, Damha MJ. Synthesis and properties of oligonucleotide chimeras containing 5'-amino-2'-deoxy-2'-fluoroarabinonucleosides. Nucleosides, Nucleotides & Nucleic Acids. 22: 1335-8. PMID 14565412 DOI: 10.1081/Ncn-120022959 |
0.409 |
|
| 2003 |
Viazovkina E, Mangos MM, Damha MJ. Synthesis and physicochemical properties of 2'-deoxy-2',2''-difluoro-beta-D-ribofuranosyl and 2'-deoxy-2',2''-difluoro-alpha-D-ribofuranosyl oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids. 22: 1251-4. PMID 14565392 DOI: 10.1081/Ncn-120022848 |
0.352 |
|
| 2003 |
Agha KA, Damha MJ. Synthesis and binding properties of a homopyrimidine 2',5'-linked xylose nucleic acid (2',5'-XNA). Nucleosides, Nucleotides & Nucleic Acids. 22: 1175-8. PMID 14565373 DOI: 10.1081/Ncn-120022829 |
0.819 |
|
| 2003 |
Denisov AY, Hannoush RN, Gehring K, Damha MJ. A novel RNA motif based on the structure of unusually stable 2',5'-linked r(UUCG) loops. Journal of the American Chemical Society. 125: 11525-31. PMID 13129354 DOI: 10.1021/Ja036207K |
0.496 |
|
| 2003 |
Carriero S, Damha MJ. Synthesis of lariat-DNA via the chemical ligation of a dumbbell complex. Organic Letters. 5: 273-6. PMID 12556170 DOI: 10.1021/Ol027227E |
0.787 |
|
| 2003 |
Mangos MM, Min KL, Viazovkina E, Galarneau A, Elzagheid MI, Parniak MA, Damha MJ. Efficient RNase H-directed cleavage of RNA promoted by antisense DNA or 2'F-ANA constructs containing acyclic nucleotide inserts. Journal of the American Chemical Society. 125: 654-61. PMID 12526664 DOI: 10.1021/Ja025557O |
0.537 |
|
| 2002 |
Viazovkina E, Mangos MM, Elzagheid MI, Damha MJ. Solid-phase synthesis of 2'-deoxy-2'-fluoro- beta-D-oligoarabinonucleotides (2'F-ANA) and their phosphorothioate derivatives. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.15. PMID 18428897 DOI: 10.1002/0471142700.Nc0415S10 |
0.331 |
|
| 2002 |
Carriero S, Damha MJ. Solid-phase synthesis of branched oligonucleotides. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.14. PMID 18428896 DOI: 10.1002/0471142700.Nc0414S09 |
0.85 |
|
| 2002 |
Elzagheid MI, Viazovkina E, Damha MJ. Synthesis of protected 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 1.7. PMID 18428885 DOI: 10.1002/0471142700.Nc0107S10 |
0.329 |
|
| 2002 |
Lacombe J, Viazovkina E, Bernatchez PN, Galarneau A, Damha MJ, Sirois MG. Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides. Canadian Journal of Physiology and Pharmacology. 80: 951-61. PMID 12450061 DOI: 10.1139/Y02-123 |
0.482 |
|
| 2002 |
Min KL, Viazovkina E, Galarneau A, Parniak MA, Damha MJ. Oligonucleotides comprised of alternating 2'-deoxy-2'-fluoro-beta-D-arabinonucleosides and D-2'-deoxyribonucleosides (2'F-ANA/DNA 'altimers') induce efficient RNA cleavage mediated by RNase H. Bioorganic & Medicinal Chemistry Letters. 12: 2651-4. PMID 12182880 DOI: 10.1016/S0960-894X(02)00439-0 |
0.497 |
|
| 2002 |
Mangos MM, Damha MJ. Flexible and frozen sugar-modified nucleic acids--modulation of biological activity through furanose ring dynamics in the antisense strand. Current Topics in Medicinal Chemistry. 2: 1147-71. PMID 12173972 DOI: 10.2174/1568026023393110 |
0.487 |
|
| 2002 |
Yazbeck DR, Min KL, Damha MJ. Molecular requirements for degradation of a modified sense RNA strand by Escherichia coli ribonuclease H1. Nucleic Acids Research. 30: 3015-25. PMID 12136083 DOI: 10.1093/Nar/Gkf429 |
0.546 |
|
| 2002 |
Lok CN, Viazovkina E, Min KL, Nagy E, Wilds CJ, Damha MJ, Parniak MA. Potent gene-specific inhibitory properties of mixed-backbone antisense oligonucleotides comprised of 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxyribose nucleotides. Biochemistry. 41: 3457-67. PMID 11876654 DOI: 10.1021/Bi0115075 |
0.732 |
|
| 2002 |
Hannoush RN, Damha MJ. Remarkable stability of hairpins containing 2',5'-linked RNA loops. Journal of the American Chemical Society. 123: 12368-74. PMID 11734039 DOI: 10.1021/Ja011336R |
0.537 |
|
| 2002 |
Hannoush RN, Damha MJ. Extra stable 2',5'-linked RNA loops. Nucleosides, Nucleotides & Nucleic Acids. 20: 1201-4. PMID 11562986 DOI: 10.1081/Ncn-100002519 |
0.526 |
|
| 2001 |
Denisov AY, Noronha AM, Wilds CJ, Trempe JF, Pon RT, Gehring K, Damha MJ. Solution structure of an arabinonucleic acid (ANA)/RNA duplex in a chimeric hairpin: comparison with 2'-fluoro-ANA/RNA and DNA/RNA hybrids. Nucleic Acids Research. 29: 4284-93. PMID 11691916 DOI: 10.1093/Nar/29.21.4284 |
0.76 |
|
| 2001 |
Ooi SL, Dann C, Nam K, Leahy DJ, Damha MJ, Boeke JD. RNA lariat debranching enzyme. Methods in Enzymology. 342: 233-48. PMID 11586896 DOI: 10.1016/S0076-6879(01)42548-1 |
0.58 |
|
| 2001 |
Carriero S, Braich RS, Hudson RH, Anglin D, Friesen JD, Damha MJ. Inhibition of in vitro pre-mRNA splicing in S. cerevisiae by branched oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids. 20: 873-7. PMID 11563135 DOI: 10.1081/Ncn-100002449 |
0.822 |
|
| 2001 |
Damha MJ, Noronha AM, Wilds CJ, Trempe JF, Denisov A, Pon RT, Gehring K. Properties of arabinonucleic acids (ANA & 20'F-ANA): implications for the design of antisense therapeutics that invoke RNase H cleavage of RNA. Nucleosides, Nucleotides & Nucleic Acids. 20: 429-40. PMID 11563058 DOI: 10.1081/Ncn-100002317 |
0.745 |
|
| 2001 |
Noronha AM, Arion D, Parniak MA, Damha MJ. Effect of substituting arabinonucleosides for deoxynucleotides in the DNA priming strand on the polymerase action of HIV-1 RT. Nucleosides, Nucleotides & Nucleic Acids. 20: 1205-9. PMID 11562987 DOI: 10.1081/Ncn-100002520 |
0.343 |
|
| 2001 |
Trempe JF, Wilds CJ, Denisov AY, Pon RT, Damha MJ, Gehring K. NMR solution structure of an oligonucleotide hairpin with a 2'F-ANA/RNA stem: implications for RNase H specificity toward DNA/RNA hybrid duplexes. Journal of the American Chemical Society. 123: 4896-903. PMID 11457316 DOI: 10.1021/Ja003859P |
0.743 |
|
| 2000 |
Wilds CJ, Damha MJ. 2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies. Nucleic Acids Research. 28: 3625-35. PMID 10982885 DOI: 10.1093/Nar/28.18.3625 |
0.741 |
|
| 2000 |
Noronha AM, Wilds CJ, Lok CN, Viazovkina K, Arion D, Parniak MA, Damha MJ. Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes. Biochemistry. 39: 7050-62. PMID 10852702 DOI: 10.1021/Bi000280V |
0.764 |
|
| 1999 |
Wilds CJ, Damha MJ. Duplex recognition by oligonucleotides containing 2'-deoxy-2'-fluoro-D-arabinose and 2'-deoxy-2'-fluoro-D-ribose. Intermolecular 2'-OH-phosphate contacts versus sugar puckering in the stabilization of triple-helical complexes. Bioconjugate Chemistry. 10: 299-305. PMID 10077480 DOI: 10.1021/Bc9801171 |
0.74 |
|
| 1999 |
Damha MJ, Noronha A. Recognition of nucleic acid double helices by homopyrimidine 2', 5'-linked RNA. Nucleic Acids Research. 26: 5152-6. PMID 9813104 DOI: 10.1093/Nar/26.22.5152 |
0.555 |
|
| 1998 |
Noronha A, Damha MJ. Triple helices containing arabinonucleotides in the third (Hoogsteen) strand: effects of inverted stereochemistry at the 2'-position of the sugar moiety. Nucleic Acids Research. 26: 2665-71. PMID 9592152 DOI: 10.1093/Nar/26.11.2665 |
0.547 |
|
| 1998 |
Wasner M, Arion D, Borkow G, Noronha A, Uddin AH, Parniak MA, Damha MJ. Physicochemical and biochemical properties of 2',5'-linked RNA and 2',5'-RNA:3',5'-RNA "hybrid" duplexes. Biochemistry. 37: 7478-86. PMID 9585561 DOI: 10.1021/Bi980160B |
0.564 |
|
| 1998 |
Robidoux S, Klinck R, Gehring K, Damha MJ. Association of branched oligonucleotides into the i-motif. Journal of Biomolecular Structure & Dynamics. 15: 517-27. PMID 9439998 DOI: 10.1080/07391102.1997.10508962 |
0.405 |
|
| 1998 |
Damha MJ, Wilds CJ, Noronha A, Brukner I, Borkow G, Arion D, Parniak MA. Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease HJ. Am. Chem. Soc.1998,120, 12976−12977 Journal of the American Chemical Society. 120: 13545-13545. DOI: 10.1021/Ja985535V |
0.723 |
|
| 1998 |
Damha MJ, Wilds CJ, Noronha A, Brukner I, Borkow G, Arion D, Parniak MA. Hybrids of RNA and Arabinonucleic Acids (ANA and 2‘F-ANA) Are Substrates of Ribonuclease H Journal of the American Chemical Society. 120: 12976-12977. DOI: 10.1021/Ja982325+ |
0.721 |
|
| 1998 |
Damha MJ, Braich RS. Synthesis of a branched DNA/RNA chimera similar to the msDNA molecule of Myxococcus xanthus Tetrahedron Letters. 39: 3907-3910. DOI: 10.1016/S0040-4039(98)00724-2 |
0.548 |
|
| 1998 |
Hudson RH, Robidoux S, Damha MJ. Divergent solid-phase synthesis of nucleic acid dendrimers Tetrahedron Letters. 39: 1299-1302. DOI: 10.1016/S0040-4039(97)10871-1 |
0.633 |
|
| 1997 |
Borkow G, Arion D, Noronha A, Scartozzi M, Damha MJ, Parniak MA. Inhibitory potency of R-region specific antisense oligonucleotides against in vitro DNA polymerization and template-switching reactions catalysed by HIV-1 reverse transcriptase. The International Journal of Biochemistry & Cell Biology. 29: 1285-95. PMID 9451826 DOI: 10.1016/S1357-2725(97)00067-8 |
0.455 |
|
| 1997 |
Uddin AH, Piunno PA, Hudson RH, Damha MJ, Krull UJ. A fiber optic biosensor for fluorimetric detection of triple-helical DNA. Nucleic Acids Research. 25: 4139-46. PMID 9321670 DOI: 10.1093/Nar/25.20.4139 |
0.609 |
|
| 1997 |
Braich RS, Damha MJ. Regiospecific solid-phase synthesis of branched oligonucleotides. Effect of vicinal 2',5'- (or 2',3'-) and 3',5'-phosphodiester linkages on the formation of hairpin DNA. Bioconjugate Chemistry. 8: 370-7. PMID 9177843 DOI: 10.1021/Bc9700300 |
0.376 |
|
| 1996 |
Uddin AH, Roman MA, Anderson JR, Damha MJ. A novel N3-functionalized thymidine linker for the stabilization of triple helical DNA Chemical Communications. 171-172. DOI: 10.1039/Cc9960000171 |
0.343 |
|
| 1995 |
Piunno PAE, Krull UJ, Hudson RHE, Damha MJ, Cohen H. Fiber-optic DNA sensor for fluorometric nucleic acid determination Analytical Chemistry. 67: 2635-2643. PMID 8849028 DOI: 10.1021/Ac00111A022 |
0.351 |
|
| 1995 |
Damha MJ, Meng B, Wang D, Yannopoulos CG, Just G. Structural basis for the RNA binding selectivity of oligonucleotide analogues containing alkylsulfide internucleoside linkages and 2'-substituted 3'-deoxyribonucleosides. Nucleic Acids Research. 23: 3967-73. PMID 7479044 DOI: 10.1093/Nar/23.19.3967 |
0.543 |
|
| 1995 |
Ganeshan K, Tadey T, Nam K, Braich R, Purdy WC, Boeke JD, Damha MJ. Novel Approaches to the Synthesis and Analysis of Branched RNA Nucleosides, Nucleotides and Nucleic Acids. 14: 1009-1013. DOI: 10.1080/15257779508012522 |
0.457 |
|
| 1995 |
Wang D, Meng B, Damha MJ, Just G. Synthesis of 2’-Substituted Sulfide-Linked Dinucleotides Nucleosides and Nucleotides. 14: 1961-1984. DOI: 10.1080/15257779508010717 |
0.304 |
|
| 1995 |
Hudson RHE, Uddin AH, Damha MJ. Association of branched nucleic acids: Structural and physicochemical analysis of antiparallel T·AT triple-helical DNA Journal of the American Chemical Society. 117: 12470-12477. DOI: 10.1021/Ja00155A011 |
0.411 |
|
| 1994 |
Damha MJ, Giannaris PA, Marfey P. Antisense L/D-oligodeoxynucleotide chimeras: nuclease stability, base-pairing properties, and activity at directing ribonuclease H. Biochemistry. 33: 7877-85. PMID 8011650 DOI: 10.1021/Bi00191A015 |
0.387 |
|
| 1994 |
Giannaris PA, Damha MJ. Hybridization properties of oligoarabinonucleotides Canadian Journal of Chemistry. 72: 909-918. DOI: 10.1139/V94-118 |
0.476 |
|
| 1994 |
Piunno PAE, Krull UJ, Hudson RHE, Damha MJ, Cohen H. Fiber optic biosensor for fluorimetric detection of DNA hybridization Analytica Chimica Acta. 288: 205-214. DOI: 10.1016/0003-2670(93)E0611-A |
0.306 |
|
| 1993 |
Kawai SH, Wang D, Giannaris PA, Damha MJ, Just G. Solid-phase synthesis and hybridization properties of DNA containing sulfide-linked dinucleosides. Nucleic Acids Research. 21: 1473-9. PMID 8464740 DOI: 10.1093/Nar/21.6.1473 |
0.437 |
|
| 1993 |
Damha MJ, Ogilvie KK. Oligoribonucleotide synthesis. The silyl-phosphoramidite method. Methods in Molecular Biology (Clifton, N.J.). 20: 81-114. PMID 8242149 DOI: 10.1385/0-89603-281-7:81 |
0.48 |
|
| 1993 |
Giannaris PA, Damha MJ. Oligoribonucleotides containing 2',5'-phosphodiester linkages exhibit binding selectivity for 3',5'-RNA over 3',5'-ssDNA. Nucleic Acids Research. 21: 4742-9. PMID 7694233 DOI: 10.1093/Nar/21.20.4742 |
0.515 |
|
| 1993 |
Damha MJ, Ganeshan K, Hudson RH, Zabarylo SV. Solid-phase synthesis of branched oligoribonucleotides related to messenger RNA splicing intermediates. Nucleic Acids Research. 20: 6565-73. PMID 1480476 DOI: 10.1093/Nar/20.24.6565 |
0.745 |
|
| 1993 |
Hudson RHE, Damha MJ. Nucleic acid dendrimers: novel biopolymer structures Journal of the American Chemical Society. 115: 2119-2124. DOI: 10.1021/Ja00059A004 |
0.372 |
|
| 1993 |
Idziak I, Just G, Damha MJ, Giannaris PA. Synthesis and hybridization properties of amide-linked thymidine dimers incorporated into oligodeoxynucleotides Tetrahedron Letters. 34: 5417-5420. DOI: 10.1016/S0040-4039(00)73923-2 |
0.475 |
|
| 1993 |
Meng B, Kawai SH, Wang D, Just G, Giannaris PA, Damha MJ. Ein Sulfidbindungen enthaltendes Oligonucleotid-Analogon mit selektiven Hybridisierungseigenschaften Angewandte Chemie. 105: 733-735. DOI: 10.1002/Ange.19931050510 |
0.374 |
|
| 1992 |
Damha MJ, Guo Y, Zabarylo SV, Ganeshan K, Giannaris PA. Tricyclic “oxadiazaphosphorine oxide” guanosines: A new strategy to the protection of guanine bases during RNA synthesis Tetrahedron Letters. 33: 6739-6742. DOI: 10.1016/S0040-4039(00)61764-1 |
0.346 |
|
| 1990 |
Damha MJ, Giannaris PA, Zabarylo SV. An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis. Nucleic Acids Research. 18: 3813-21. PMID 2374710 DOI: 10.1093/Nar/18.13.3813 |
0.302 |
|
| 1990 |
Lafortune F, Damha MJ, Tang X, Standing KG, Westmore JB, Ogilvie KK. Time-of-flight Secondary Ion Mass Spectrometry of Branched RNA Fragrants: Messenger RNA Splicing Intermedistes Nucleosides and Nucleotides. 9: 445-446. DOI: 10.1080/07328319008045167 |
0.581 |
|
| 1989 |
Damha MJ, Usman N, Ogilvie KK. Solution and solid phase chemical synthesis of arabinonucleotides Canadian Journal of Chemistry. 67: 831-839. DOI: 10.1139/V89-129 |
0.543 |
|
| 1989 |
Damha MJ, Zabarylo S. Automated solid-phase synthesis of branched oligonucleotides Tetrahedron Letters. 30: 6295-6298. DOI: 10.1016/S0040-4039(01)93876-6 |
0.488 |
|
| 1989 |
DAMHA MJ, USMAN N, OGILVIE KK. ChemInform Abstract: Solution and Solid Phase Chemical Synthesis of Arabinonucleotides. Cheminform. 20. DOI: 10.1002/chin.198941320 |
0.46 |
|
| 1989 |
DAMHA MJ, OGILVIE KK. ChemInform Abstract: Synthesis and Spectroscopic Analysis of Branched RNA Fragments: Messenger RNA Splicing Intermediates. Cheminform. 20. DOI: 10.1002/chin.198906312 |
0.66 |
|
| 1988 |
Damha MJ, Ogilvie KK. Conformational properties of branched RNA fragments in aqueous solution. Biochemistry. 27: 6403-16. PMID 2464368 DOI: 10.1021/Bi00417A032 |
0.544 |
|
| 1988 |
Damha MJ, Ogilvie KK. Synthesis and spectroscopic analysis of branched RNA fragments: messenger RNA splicing intermediates The Journal of Organic Chemistry. 53: 3710-3722. DOI: 10.1021/Jo00251A010 |
0.695 |
|
| 1988 |
Lafortune F, Standing KG, Westmore JB, Damha MJ, Ogilvie KK. Differentiation between protected diastereomeric trinucleotides by time-of-flight secondary ion mass spectrometry Organic Mass Spectrometry. 23: 228-230. DOI: 10.1002/Oms.1210230314 |
0.466 |
|
| 1987 |
Ogilvie KK, Damha MJ, Usman N, Pon RT. Developments in the chemical synthesis of naturally occurring DNA and RNA sequences with normal and unusual linkages Pure and Applied Chemistry. 59: 325-330. DOI: 10.1351/Pac198759030325 |
0.681 |
|
| 1987 |
Damha MJ, Usman N, Ogilvie KK. The rapid chemical synthesis of arabinonucleotides Tetrahedron Letters. 28: 1633-1636. DOI: 10.1016/S0040-4039(00)95378-4 |
0.534 |
|
| 1987 |
DAMHA MJ, USMAN N, OGILVIE KK. ChemInform Abstract: The Rapid Chemical Synthesis of Arabinonucleotides. Cheminform. 18. DOI: 10.1002/chin.198739318 |
0.506 |
|
| 1987 |
OGILVIE KK, DAMHA MJ, USMAN N, PON RT. ChemInform Abstract: Developments in the Chemical Synthesis of Naturally Occurring DNA and RNA Sequences with Normal and Unusual Linkages. Cheminform. 18. DOI: 10.1002/chin.198736326 |
0.643 |
|
| 1987 |
DAMHA MJ, OGILVIE KK. ChemInform Abstract: Modification of Guanine Bases: Reaction of N2-Acylated Guanine Nucleosides with Dichloro-(N,N-diisopropylamino)phosphine. Cheminform. 18. DOI: 10.1002/chin.198710320 |
0.43 |
|
| 1986 |
Pon RT, Usman N, Damha MJ, Ogilvie KK. Prevention of guanine modification and chain cleavage during the solid phase synthesis of oligonucleotides using phosphoramidite derivatives. Nucleic Acids Research. 14: 6453-70. PMID 3748816 DOI: 10.1093/Nar/14.16.6453 |
0.548 |
|
| 1986 |
Damha MJ, Ogilvie KK. Modification of guanine bases: reaction of N2-acylated guanine nucleosides with dichloro-(N,N-diisopropylamino)phosphine The Journal of Organic Chemistry. 51: 3559-3560. DOI: 10.1021/Jo00368A037 |
0.488 |
|
| 1985 |
Pon RT, Damha MJ, Ogilvie KK. Modification of guanine bases by nucleoside phosphoramidite reagents during the solid phase synthesis of oligonucleotides. Nucleic Acids Research. 13: 6447-65. PMID 4059050 DOI: 10.1093/Nar/13.18.6447 |
0.559 |
|
| 1985 |
Pon RT, Damha MJ, Ogilvie KK. Necessary protection of the O6-position of guanine during the solid phase synthesis of oligonucleotides by the phosphoramidite approach Tetrahedron Letters. 26: 2525-2528. DOI: 10.1016/S0040-4039(00)98827-0 |
0.545 |
|
| 1985 |
Damha MJ, Pon RT, Ogilvie KK. Chemical synthesis of branched RNA: novel trinucleoside diphosphates containing vicinal 2′–5′ and 3′–5′ phosphodiester linkages Tetrahedron Letters. 26: 4839-4842. DOI: 10.1016/S0040-4039(00)94965-7 |
0.679 |
|
| 1985 |
PON RT, DAMHA MJ, OGILVIE KK. ChemInform Abstract: NECESSARY PROTECTION OF THE O6-POSITION OF GUANINE DURING THE SOLID PHASE SYNTHESIS OF OLIGONUCLEOTIDES BY THE PHOSPHORAMIDITE APPROACH Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198537319 |
0.482 |
|
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